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Beta-lactamase

Beta-lactamase is an enzyme produced by certain bacteria that provides resistance to beta-lactam antibiotics, such as penicillins, cephalosporins, and carbapenems. These antibiotics contain a beta-lactam ring, which is essential for their antibacterial activity. Beta-lactamase catalyzes the hydrolysis of the beta-lactam ring, rendering the antibiotic inactive and allowing bacteria to survive.

Metallo-β-lactamase-IN-16
T2010212058069-25-1
Metallo-β-lactamase-IN-16 (compound 18) 作为一种含砜基团的抑制剂,针对多种金属-β-内酰胺酶展示出显著的抗菌活性。该化合物有效抑制 NDM-1(新德里金属-β-内酰胺酶-1)、IMP-1(亚胺培南酶-1)、VIM-1(维罗纳整合子编码的金属-β-内酰胺酶)及 VIM-2,其IC50值分别为 0.16 nM、0.23 nM、0.31 nM 和 1.0 nM,表现出其对这些酶的高效抑制能力。
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