60
14
1
41
7
Cat. No. | Product Name | ||
---|---|---|---|
L1110 | 微管靶向化合物库 | 142 compounds | |
142 种靶向微管的分子集合,用于高通量筛选和高内涵筛选; |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T79508 |
Microtubule stabilizing agent-1
|
Others | Others |
Microtubule stabilizing agent-1 (compound 3l),作为一种紫杉醇衍生物,能够有效地促进微管蛋白聚合 (tubulin polymerization),并且展现了显著的抗肿瘤效能。 | |||
T7806 |
Licarbazepine
10,11-hydroxy-10,11 Dihydrocarbamezer,10,11-二氢-10-羟基卡马西平 |
Others | Others |
Licarbazepine (10,11-hydroxy-10,11 Dihydrocarbamezer) 是一种有效的电压门控钠通道阻滞剂,具有抗惊厥和稳定情绪的功效。 | |||
T9409 |
Mesdopetam hemitartrate
IRL790 hemitartrate,1-Propanamine, N-[2-[3-fluoro-5-(methylsulfonyl)phenoxy]ethyl]-, (2R,3R)-2,3-dihydroxybutanedioate (2:1) |
Dopamine Receptor | GPCR/G Protein; Neuroscience |
Mesdopetam hemitartrate (IRL790 hemitartrate) 是一种多巴胺D3受体拮抗剂 (Ki=90 nM;IC50=9.8 μM),具有稳定精神运动的作用,可用于帕金森病的运动和精神并发症的研究。 | |||
T74166 |
Microtubule destabilizing agent-1
|
Others | Others |
Microtubule destabilizing agent-1 (Compound 12b)为基于异羟肟酸的微管去稳定剂(MDA)。该化合物表现出良好的代谢稳定性、高生物利用度及有效的抗肿瘤活性。 | |||
TQ0013 |
BTTAA
|
Others | Others |
BTTAA 是 Cu(I)-稳定配体,能够的有效与泛素 Glu18AzF 反应。 | |||
T5938 |
4-Phenoxybenzylamine
|
HCV Protease | Microbiology/Virology; Proteases/Proteasome |
4-Phenoxybenzylamine 通过稳定无活性构象来抑制NS3蛋白的功能,对 HCV NS3/4a 的 IC50 约为 500 μM。 | |||
T7409 |
360A
3,3'-[2,6-吡啶二基二(羰基亚氨基)]二[1-甲基喹啉鎓] |
DNA/RNA Synthesis; Telomerase | Cell Cycle/Checkpoint; DNA Damage/DNA Repair |
360A 是一种稳定的G-四链体配体,还抑制 TRAP-G4 试验中端粒酶的端粒酶活性,IC50值为 300 nM。 | |||
T24239 |
K201
K-201,JTV 519,JTV-519,K 201 |
Calcium Channel | Membrane transporter/Ion channel; Metabolism |
K201 (JTV-519) 是一种 Ca2+ 依赖性阻滞剂,通过稳定兰尼碱受体来防止缺血性心脏和骨骼肌 (SkM) 中的肌质网异常 Ca(2+) 泄漏。 | |||
T11147 |
EC5026
BPN-19186 |
Epoxide Hydrolase | Metabolism |
EC5026 (BPN-19186) 是首创的,非阿片类的,可溶性环氧水解酶 (sEH) 抑制剂,它可有效缓解发炎性和神经性疼痛。 | |||
T65287 |
MES monohydrate
|
Others | Others |
MES monohydrate 是一种两性离子缓冲液,是一种 PH 稳定试剂,可用于蛋白质纯化和酶测定。 | |||
T1170 |
Olopatadine hydrochloride
盐酸奥洛他定,Olopatadine HCl,KW4679,ALO4943A |
5-HT Receptor; Histamine Receptor | GPCR/G Protein; Immunology/Inflammation; Neuroscience |
Olopatadine hydrochloride (ALO4943A) 是一种抗组胺药,具有稳定肥大细胞的特性,用作治疗过敏性结膜炎的滴眼液。 | |||
T13951 |
UCB-9260
|
TNF | Apoptosis |
UCB-9260 是口服活性小分子,通过稳定三聚体的不对称形式抑制肿瘤坏死因子信号传导。它对肿瘤坏死因子的选择性高于其他超家族成员,并与肿瘤坏死因子结合,其Kd 值为 13 nM。 | |||
T21470L |
Davunetide acetate
Davunetide acetate(211439-12-2 Free base) |
Beta Amyloid; Microtubule Associated | Cytoskeletal Signaling; Neuroscience |
Davunetide acetate 源自哺乳动物 CNS 中存在的活性依赖性神经保护蛋白。 Davunetide acetate 是一种微管稳定肽,可抑制 Aβ 聚集和 Aβ 诱导的神经毒性。 Davunetide acetate 具有神经保护、神经营养和认知保护特性。 | |||
T77516 |
SARS-CoV-2-IN-39
|
Antiviral; SARS-CoV | Immunology/Inflammation; Microbiology/Virology |
SARS-CoV-2-IN-39是一种 SARS-CoV-2 抑制剂,EC50 为 1 μM。 SARS-CoV-2-IN-39 具有抗病毒活性,通过抑制 SKP2 蛋白并稳定 BECN1 来抑制 SARS-CoV-2。 | |||
T9095 |
Necrostatin-34
2-{[3-cyano-4-(4-methylphenyl)-6-oxo-1,4 |
RIP kinase | Apoptosis; NF-κB |
Necrostatin-34 (2-{[3-cyano-4-(4-methylphenyl)-6-oxo-1,4) 是一种 RIPK1 激酶抑制剂,通过在激酶结构域中占据一个独特的结合口袋,将 RIPK1 激酶稳定在非活性构象中。 | |||
T26360 |
Benperidol
R4584,R-4584,Anquil,McN-JR-4584,R 4584 |
Others | Others |
Benperidol (Anquil)是一种具有抗精神病和安定作用的丁酮类化合物,在阻断 D2 受体方面具有很好的疗效。Benperidol可用于正电子发射断层扫描(PET)测量体内 D(2)类多巴胺受体的结合情况。 | |||
T0939 |
Phenytoin
苯妥英,Diphenylhydantoin,5,5-Diphenylhydantoin |
Virus Protease; Sodium Channel | Membrane transporter/Ion channel; Microbiology/Virology |
Phenytoin (5,5-Diphenylhydantoin) 是一种有效的电压门控钠离子通道阻滞剂,可减少小鼠乳腺肿瘤的生长和转移,具有抗癫痫活性。 | |||
T1320 |
Disopyramide
Triombrin,Hypaque sodium,amidotrizoate sodium,达舒平 |
Potassium Channel; Sodium Channel; AChR | Membrane transporter/Ion channel; Neuroscience |
Disopyramide (Triombrin) 是用于研究房性和室性心律失常的 IA 类抗心律失常试剂。它阻断心肌快速内向钠电流,延长心肌动作电位持续时间。它抑制 HERG 编码的钾通道。它也表现出复杂的蛋白质结合,并具有强大的负性肌力作用。 | |||
T1282 |
Carteolol hydrochloride
Arteoptic,Abbott-43326,OPC-1085 hydrochloride,盐酸卡替洛尔,Carteolol HCl,Mikelan |
Adrenergic Receptor | GPCR/G Protein; Neuroscience |
Carteolol hydrochloride (Abbott-43326) 是一种非选择性的β肾上腺素受体阻断剂。 | |||
T77520 |
AOH1996
|
Apoptosis; DNA/RNA Synthesis | Apoptosis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair |
AOH1996 是一种具有口服活性的复制体组分 PCNA (增殖细胞核抗原) 配体,靶向转录-复制冲突 (TRC)。AOH1996 可干扰 PCNA 与其结合蛋白的相互作用,导致 DNA 复制应激,诱导细胞凋亡 (apoptosis)。AOH1996 通过稳定 PCNA 和 RNA 聚合酶 II 的相互作用从而导致蛋白酶体依赖的 rpb1 降解和致命的 DNA 损伤。AOH1996 与 DNA 损伤剂具有协同作用,可抑制肿瘤细胞生长。 | |||
T15713 |
Larotaxel
XRP9881 |
P-gp | Membrane transporter/Ion channel; Neuroscience |
Larotaxel (XRP9881) 是一种紫杉烷类似物,具有抗癌活性,通过促进微管蛋白装配和稳定微管发挥其细胞毒性作用,并通过细胞凋亡诱导细胞死亡。Larotaxel (XRP9881) 是一种可穿过血脑屏障的化合物,对 Docetaxel 的亲和力比 P-糖蛋白 1 高,可用于研究乳腺癌和膀胱癌。 | |||
T1012 |
Acebutolol hydrochloride
盐酸醋丁洛尔,Acebutolol HCl |
Adrenergic Receptor | GPCR/G Protein; Neuroscience |
Acebutolol hydrochloride (Acebutolol HCl) 是一种 β-肾上腺素受体拮抗剂,用于研究高血压、心绞痛和心律失常。 | |||
T1602 |
Valproic acid sodium salt
丙戊酸钠,Sodium Valproate |
Mitophagy; Gamma-secretase; HIV Protease; GABA Receptor; HDAC; Autophagy | Autophagy; Chromatin/Epigenetic; DNA Damage/DNA Repair; Membrane transporter/Ion channel; Microbiology/Virology; Neuroscience; Proteases/Proteasome; Stem Cells |
Valproic acid sodium salt (Sodium Valproate) 是一种HDAC 抑制剂,可抑制HDAC1的活性,诱导HDAC2的降解。它激活Notch1信号并抑制小细胞肺癌细胞的增殖。它可研究癫痫、偏头痛和双相情感障碍等。 | |||
T35841 |
5-Benzyloxygramine
|
Dopamine Receptor; 5-HT Receptor | GPCR/G Protein; Neuroscience |
5-Benzyloxygramine 是一种 N 蛋白、蛋白互作的原位稳定剂,具有抗病毒和稳定 N-NTD 蛋白的作用。它能够阻断多巴胺受体,可拮抗 5-HT 对大鼠子宫和兔耳的作用。 | |||
T24788 |
Shield-2
|
Others | Others |
Shield-2 is a potent FKBP-derived destabilizing domain stabilizing ligand. | |||
T32146 |
IMC-48
NSC 138948,NSC-138948,IMC48,NSC138948 |
Others | Others |
IMC-48, as a BCL2 i-motif-interactive compound, can act by stabilizing or facilitating the folding of the i-motif. | |||
T17001 |
Tazanolast
他扎司特,Tazalest,TO 188,Tazanol |
Others | Others |
Tazanolast is a selective mast-cell-stabilizing drug. | |||
T70878 |
P516-0475
|
Others | Others |
P516-0475 is a novel chemical inducer of Streptococcus quorum sensing acts by inhibiting the pheromone-degrading endopeptidase PepO. This compound induces quorum sensing by stabilizing SHP pheromones in culture. | |||
T70983 |
Zoledronate disodium
|
Others | Others |
Zoledronate disodium is an inhibitor of osteoclastogenesis and macrophage recruitment, decreasing bone turnover and stabilizing the bone matrix, exhibiting diverse anti-tumor effects in osteosarcoma. | |||
T35879 |
Octyl glucose neopentyl glycol
|
Others | Others |
Octyl glucose neopentyl glycol (OGNG) is a detergent derived from neopentyl glycol, intended for stabilizing membrane proteins [1]. | |||
T27521 |
GX-936
GX 936,PF 05196233,PF05196233,GX936,PF-05196233 |
Others | Others |
GX-936, a Nav1.7 inhibitor, inhibits Nav1.7 through a voltage-sensor trapping mechanism, likely by stabilizing inactivated states of the channel. | |||
T40558 |
Triclosan-methyl
|
Others | Others |
Triclosan-methyl is a derivative of triclosan, which functions as a bactericide in various personal care products including toothpaste, shampoos, and soaps. Additionally, triclosan serves as a stabilizing agent in numerous detergents and cosmetics. | |||
TP1977 |
187-1, N-WASP inhibitor
|
||
Inhibits neural Wiskott-Aldrich syndrome protein (N-WASP) by stabilizing the autoinhibited state of the protein. Blocks phosphatidylinositol 4,5-bisphosphate (PIP2)-stimulated actin assembly (IC50 ~ 2 μM) but does not directly inhibit actin polymerization | |||
T84372 |
G-9807
|
Others | Others |
G-9807 通过稳定活性二聚体单元,充当 RNase 的变构激活,显著提高 IRE1-KR-0P 的 RNase 活性。 | |||
T5450 |
DL-071-IT
Afurolol Hydrochloride,DL 071 IT |
Adrenergic Receptor | GPCR/G Protein; Neuroscience |
DL-071-IT (Afurolol Hydrochloride) 是一种有效的非选择性β-肾上腺素受体拮抗剂。 DL-071-IT 表现出内在的拟交感神经活性和弱的膜稳定活性。 | |||
T38439 |
DC-Srci-6649
|
Others | Others |
DC-Srci-6649 is a potent and selective inhibitor of c-Src kinase, effectively blocking its phosphorylation and stabilizing it in an inactive conformation. | |||
T21191 |
Phosphonic acid, P-decyl-
1-Decanephosphonic acid,Decanephosphonic acid,Decylphosphonic acid |
||
Phosphonic acid, P-decyl- is used as an important raw material and intermediate in organic synthesis, agrochemicals, dyestuff, and pharmaceuticals. It is also used in stabilizing dye-sensitized solar cells. | |||
T67809 |
simotaxel
|
Others | Others |
Simotaxel 是一种半合成的、口服生物可利用的第三代紫杉烷衍生物和微管稳定剂,具有潜在的抗肿瘤活性。 | |||
T76054 |
SAHM1 TFA
|
||
SAHM1 TFA is a chemical compound that acts as a Notch pathway inhibitor by stabilizing a hydrocarbon-stapled alpha helical peptide. It specifically targets the protein-protein interface, effectively preventing the assembly of the Notch complex. | |||
T85281 |
Taurohyocholic Acid sodium
Taurohyocholate,THCA,Tauro-γ-muricholic Acid,Taurine Hyocholate |
Others | Others |
Taurohyocholic acid (THCA), a taurine-conjugated form of porcine-specific primary bile acid hyocholic acid, inhibits cholesterol crystal precipitation by stabilizing cholesterol in the liquid-crystalline phase and prevents cholestasis and cellular necrosis in isolated rat livers induced by taurolithocholic acid. Additionally, THCA levels rise in the urine of patients with hepatitis B-induced cirrhosis. | |||
T37063 |
Laulimalide
|
Others | Others |
Microtubule stabilizing agent. Potent inhibitor of cellular proliferation in cancer cell lines (IC50 reported to be 3-30 nM, dependent on cell line used). Causes cells to arrest in the prometaphase of the cell cycle, prevents formation of bipolar spindle and increases kinetochore tension in preformed spindles. Pryor et al (2002) The microtubule stabilizing agent laulimalide does not bind in the taxoid site, kills cells resistant to PacT. and epothilones, and may not require its epoxide moiety fo... | |||
T31530 |
Disoxaril
BRN 3626820,WIN51711,WIN-51711,BRN-3626820,WIN 51711,WIN-51,711 |
Others | Others |
Disoxaril (BRN 3626820, WIN 51711) is an anti-picornavirus agent that inhibits enterovirus replication by binding to a hydrophobic bag within the VP1 coat protein, thereby stabilizing virions and preventing their uncoating. When used in combination with A | |||
T69880 |
YW2065
|
Others | Others |
YW2065 has excellent anti-colorectal cancer effects in vitro and in vivo. YW2065 achieves its inhibitory activity for Wnt signaling by stabilizing Axin-1, a scaffolding protein that regulates proteasome degradation of β-catenin. Simultaneously, YW2065 also led to the activation of the tumor suppressor AMPK, providing an additional anticancer mechanism. In addition, YW2065 showed favorable pharmacokinetic properties without obvious toxicity. | |||
T36485 |
Becatecarin
|
Others | Others |
Becatecarin is a water-soluble, diethylaminoethyl analog of the antineoplastic antibiotic rebeccamycin. It intercalates into DNA, stabilizing the DNA-topoisomerase complex. This results in the potent catalytic inhibition of both topoisomerases I and II, initiating DNA cleavage and apoptosis. Becatecarin, alone or in combination with other compounds, has anti-cancer as well as myelosuppressive effects in vivo. It is also a transport substrate of the ATP-binding cassette (ABC) transporter ABCG2. | |||
T38828 |
Mesdopetam
IRL790 |
Others | Others |
Mesdopetam (IRL790) is a dopamine D3 receptor antagonist with a Ki of 90 nM and an IC50 of 9.8 μM for the human recombinant D3 receptor. It exhibits psychomotor stabilizing properties and is utilized in the study of motor and psychiatric complications associated with Parkinson's disease. | |||
T71785 |
GUN35758
|
Others | Others |
GUN35758, also known as 4'-Carboxybenzo-18C6, is a novel transthyretin (ttr) amyloidogenesis inhibitor, stabilizing the ttr tetramer by binding to the allosteric sites on the molecular surface of the ttr tetramer. This product has no formal name at the moment. For the convenience of communication, a temporary code name was therefore proposed according to MedKoo Chemical Nomenclature (see web page: https://www.medkoo.com/page/naming). | |||
T74961 |
Anticancer agent 84
|
Others | Others |
Anticancer agent 84 是抗癌剂。Anticancer agent 84 通过稳定 G-四链体 (G4) 结构来抑制c-MYC 的转录。Anticancer agent 84 可用于癌症研究。 | |||
T37846 |
Taurohyocholic Acid (sodium salt)
|
Others | Others |
Taurohyocholic acid (THCA) is a taurine-conjugated form of the porcine-specific primary bile acid hyocholic acid .1THCA inhibits precipitation of cholesterol crystals by stabilizing cholesterol in the liquid-crystalline phase.2It prevents cholestasis and cellular necrosis induced by taurolithocholic acid in isolated rat livers.3THCA levels are increased in the urine of patients with hepatitis B-induced cirrhosis.4 | |||
T78884 |
Aβ-IN-7
|
Others | Others |
Aβ-IN-7 (compound 5a) 作为一种抗Aβ聚集剂,其在浓度50 μM下,能够稳定Aβ单体于小寡聚体形态,并有效延缓成核过程。相比于Aβ-IN-8,Aβ-IN-7在同等浓度下对Aβ原纤维的形成具有更优的抑制效果。 | |||
T73674 |
Poly (I:C):Kanamycin (1:1)
|
Others | Others |
Poly (I:C):Kanamycin (1:1) 是一种 Poly (I:C) 与卡那霉素 (kanamycin) 以 1:1 比例混合得到的化合物。Poly (I:C) 为双链 RNA 的合成模拟物,充当 TLR3 受体的激动剂,而卡那霉素则能够增强 Poly (I:C) 的稳定性。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T7964 |
Isomalt
异麦芽酮糖醇,Palatinitol,Palatinit |
Others; Dehydrogenase | Metabolism; Others |
Isomalt (Palatinitol) 是无毒的、具有良好耐受性的多元醇和蛋白质稳定的赋形剂,在冷冻干燥过程中可适度稳定乳酸脱氢酶(LDH),并在储存期间表现更好。它传统上在食品工业中用作甜味剂,也在制药中用作压片赋形剂。 | |||
T3253 |
Castor oil
Ricinus Oil,蓖麻油,Xenaderm,Venelex |
Others | Others |
Castor oil (Xenaderm) 是天然甘油三酯和溶剂。它可用作形成聚合物-纳米颗粒复合材料的溶剂、助溶剂、稳定剂和多元醇。它具有缓泻作用,可诱导怀孕女性分娩。 | |||
T6490 |
Epothilone A
埃博霉素 A,epothile,Epo A |
Apoptosis; Microtubule Associated | Apoptosis; Cytoskeletal Signaling |
Epothilone A (Epo A) 是紫杉醇和管蛋白聚合物结合的一种竞争性抑制剂,其Ki 值为 0.6-1.4 μM。 | |||
T16674 |
Pseudouridine
|
Endogenous Metabolite | Metabolism |
Pseudouridine 是非编码 RNA 中丰富的修饰核苷,通过稳定 RNA 结构增强核糖体 RNA 和的转移 RNA 功能。 | |||
T5S1989 |
Apiin
Apioside,芹菜苷 |
Others | Others |
Apiin (Apioside) 是Apium graveolens 叶片的一种主要成分,具有抗炎作用。它在体外抑制亚硝酸盐产生的IC50值为0.08 mg/mL,在 LPS 激活的 J774.A1 细胞中抑制 iNOS 的表达的IC50值为0.049 mg/ mL。 | |||
T0486L |
Irinotecan Hydrochloride
盐酸伊立替康,伊立替康盐酸盐,Camptothecin 11 hydrochloride,CPT-11 hydrochloride |
Topoisomerase; Autophagy | Autophagy; DNA Damage/DNA Repair |
Irinotecan Hydrochloride (CPT-11 hydrochloride) 是喜树碱半合成衍生物的盐酸盐,是一种拓扑异构酶 I 抑制剂,可研究结肠癌和直肠癌。 | |||
TN2254 |
Taccalonolide A
根薯酮内酯A,根薯酮内酯 A |
Apoptosis; Microtubule Associated | Apoptosis; Cytoskeletal Signaling |
Taccalonolide A 是从水田七根茎中分离得到的一种类固醇,具有细胞毒性和抗疟活性。它在体外对过表达 p 糖蛋白、多药耐药蛋白 7 细胞系有抑制作用,抑制 SK-OV-3 细胞生长的 IC50值为 622 nM。它是微管稳定剂,能引起 G2-M 期滞留、Bcl-2 磷酸化,并引发细胞凋亡。 | |||
T21027 |
Guar gum
Guaran,Gum cyamopsis,Gum guar,Guar flour |
Others | Others |
Guar gum is a galactomannan polysaccharide extracted from guar beans, it has stabilizing and thickening properties useful in food, feed, and industrial applications. | |||
T10763 |
Ceratamine A
|
Others | Others |
Ceratamine A is an antimitotic heterocyclic alkaloid isolated from the marine sponge Pseudoceratina sp., acts as a microtubule-stabilizing agent with cytotoxicity against human cancer cell lines. | |||
T28122 |
Myrtenal
NSC-54384,NSC 54384,NSC54384,Benihinal |
||
Myrtenal is a natural monoterpene. It is found to attenuate diethylnitrosamine-induced hepatocellular carcinoma in rats by stabilizing intrinsic antioxidants and modulating apoptotic and anti-apoptotic cascades. Myrtenal also inhibits acetylcholinesterase | |||
TN3931 |
ent-11alpha-Hydroxy-15-oxokaur-16-en-19-oic acid
|
ERK; BCL; p38 MAPK; NF-κB; Caspase; JNK; p53 | Apoptosis; MAPK; NF-κB; Proteases/Proteasome |
Ent-11alpha-Hydroxy-15-oxokaur-16-en-19-oic acid has anti-cancer activity, it induces apoptosis of human malignant cancer cells, it also inhibits hepatocellular carcinoma in vitro and in vivo via stabilizing IkBα. | |||
T72964 |
Dictyostatin
Dictyostatin 1,(-)-Dictyostatin ; Dictyostatin 1,(-)-Dictyostatin |
Others | Others |
Dictyostatin ((-)-Dictyostatin ; Dictyostatin 1) 是一种有效的微管稳定剂。 Dictyostatin 也是一种抗癌剂。 Dictyostatin 具有抗增殖活性。Dictyostatin 具有研究 tauopathies 的潜力。 | |||
T83405 |
2,3-Diphosphoglyceric acid
2,3-DPG |
Others | Others |
2,3-Diphosphoglyceric acid (2,3-DPG) 是一种糖酵解途径的中间产物,能够通过变构作用结合并稳定脱氧血红蛋白,从而促进氧气在组织部位的释放。此外,2,3-Diphosphoglyceric acid 与血红蛋白结合,有效降低了其对氧的亲和力。 | |||
T73402 |
Flavipin
|
Others | Others |
Flavipin 是一种芳香烃受体(Ahr)激动剂,可诱导小鼠 CD4+T 细胞和 CD11b+巨噬细胞表达 Ahr 下游基因。Flavipin 抑制 Arid5a 在 Il23a3'UTR 上的稳定功能,这是一种新发现的靶 mRNA。Flavipin 具有清除 DPPH 自由基的能力,IC50值为7.2 μM,对α-葡萄糖苷酶具有较强的抑制作用,IC50值为 33.8 μM。 |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-03603 |
AHSP Protein, Human, Recombinant
ERAF,alpha hemoglobin stabilizing protein,α hemoglo... |
Human | E. coli |
AHSP, also known as ERAF, is a conserved mammalian erythroid protein which belongs to the AHSP family. It is expressed in blood and bone marrow. AHSP facilitates the production of Hemoglobin A by stabilizing free α-globin. It rapidly binds to ferrous α with association (k'(AHSP)) and dissociation (k(AHSP)) rate constants of ≈1 μm(-1) s(-1) and .2 s(-1), respectively, at pH 7.4 at 22 ℃. A small slow phase was observed when AHSP binds to excess ferrous αCO. This slow phase appears to be due to cis... | |||
TMPH-01639 |
MAPK1IP1L Protein, Human, Recombinant (hFc)
Mitogen-activated protein kinase 1-interacting protein 1-lik... |
Human | HEK293 Cells |
N/A. MAPK1IP1L Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-hFc tag. The predicted molecular weight is 53.1 kDa and the accession number is Q8NDC0. | |||
TMPY-04329 |
Vimentin Protein, Human, Recombinant (His)
CTRCT30,HEL113,vimentin |
Human | Baculovirus Insect Cells |
Vimentin is a type III intermediate filament (IF) protein found in various non-epithelial cells, especially mesenchymal cells. A vimentin monomer, has a central α-helical domain and carboxyl (tail) domains. Two monomers compose the basic subunit of vimentin assembly. Vimentin is crucial for supporting and anchoring the position of the organelles in the cytosol. Vimentin provided cells with a resilience absent from the microtubule or actin filament networks, when under mechanical stress in vivo. ... | |||
TMPY-02185 |
Coagulation factor XIII B/F13B Protein, Human, Recombinant (His)
Coagulation factor 13,coagulation factor XIII, B polypeptide... |
Human | HEK293 Cells |
Coagulation factor XIII B chain, also known as Fibrin-stabilizing factor B subunit, Protein-glutamine gamma-glutamyltransferase B chain, Transglutaminase B chain and F13B, is a secreted protein which contains 1 Sushi ( CCP / SCR ) domains. Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of 2 A subunits and 2 B subunits. The A subunits have catalytic function, and the B subunits do not have en... | |||
TMPH-02847 |
CNPY2 Protein, Mouse, Recombinant (His & Myc)
MIR-interacting saposin-like protein,Tmem4,Transmembrane pro... |
Mouse | E. coli |
Positive regulator of neurite outgrowth by stabilizing myosin regulatory light chain (MRLC). It prevents MIR-mediated MRLC ubiquitination and its subsequent proteasomal degradation. | |||
TMPK-01486 |
HLA-A*24:02&B2M&Survivin 2B (AYACNTSTL) Tetramer Protein, Human, MHC (His & Avi)
svn-2B,Survivin-2B,svn 2B |
Human | HEK293 Cells |
Survivin-2B, a known splice variant of survivin, has been reported to promote cell death in some cancer cells, although it keeps prosurvival function in others.survivin-2B promoted autophagy and further regulated cell death by accumulating and stabilizing IKK alpha in the nucleus. | |||
TMPH-02252 |
TPM3 Protein, Human, Recombinant (GST)
Gamma-tropomyosin,Tropomyosin alpha-3 chain,Tropomyosin-3,TP... |
Human | E. coli |
Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. | |||
TMPH-02191 |
Tetraspanin-2/TSPAN2 Protein, Human, Recombinant
Tetraspanin-2,TSPAN2,Tetraspan NET-3 |
Human | E. coli |
May play a role in signalling in oligodendrocytes in the early stages of their terminal differentiation into myelin-forming glia and may also function in stabilizing the mature sheath. Tetraspanin-2/TSPAN2 Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 8.8 kDa and the accession number is O60636. | |||
TMPK-01481 |
HLA-A*24:02&B2M&Survivin 2B (AYACNTSTL) Monomer Protein, Human, MHC (His & Avi), Biotinylated
svn 2B,svn-2B,Survivin-2B |
Human | HEK293 Cells |
Survivin-2B, a known splice variant of survivin, has been reported to promote cell death in some cancer cells, although it keeps prosurvival function in others.survivin-2B promoted autophagy and further regulated cell death by accumulating and stabilizing IKK alpha in the nucleus. | |||
TMPK-00936 |
CKAP4 Protein, Human, Recombinant (His)
Climp-63,ERGIC-63,p63 |
Human | E. coli |
Cytoskeleton-associated protein 4 (CKAP4) is located in the rough endoplasmic reticulum (ER) and plays an important role in stabilizing the structure of ER. Meanwhile, CKAP4 is also found to act as an activated receptor at the cell surface. CKAP4 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-His tag. The predicted molecular weight is 53.66 kDa and the accession number is Q07065. | |||
TMPK-01487 |
HLA-A*24:02&B2M&Survivin 2B (AYACNTSTL) Monomer Protein, Human, MHC (His & Avi)
svn-2B,Survivin-2B,svn 2B |
Human | HEK293 Cells |
Survivin-2B, a known splice variant of survivin, has been reported to promote cell death in some cancer cells, although it keeps prosurvival function in others.survivin-2B promoted autophagy and further regulated cell death by accumulating and stabilizing IKK alpha in the nucleus. | |||
TMPH-03212 |
TPM1 Protein, Rabbit, Recombinant (His & Myc)
TPM1,Alpha-tropomyosin,Tropomyosin alpha-1 chain,Tropomyosin... |
Rabbit | Baculovirus Insect Cells |
Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. TPM1 Protein, Rabbit, Recombinant (His & Myc) is expressed in Baculovirus insect cells with N-10xHis and C-Myc tag. The predicted molecular weight is 3... | |||
TMPH-00754 |
Capsid decoration Protein, Escherichia phage lambda, Recombinant (GST)
Gene product D,Auxiliary protein D,Major capsid protein D,gp... |
Escherichia phage lambda | E. coli |
Stabilizes the expansion of the capsid head shell after genome packaging. The packaging of viral genome in the procapsid triggers a dramatic reconfiguration of the capsid shell, expanding from roughly 50nm to 60nm while the capsid thickness decreases. 415 capsid decoration protein molecules cooperatively bind the expanded capsid, thereby stabilizing the mature capsid shell. Capsid decoration Protein, Escherichia phage lambda, Recombinant (GST) is expressed in E. coli expression system with N-GST... | |||
TMPH-02636 |
Elastin Protein, Mouse, Recombinant (His)
Elastin,Tropoelastin,Eln |
Mouse | E. coli |
Major structural protein of tissues such as aorta and nuchal ligament, which must expand rapidly and recover completely. Molecular determinant of the late arterial morphogenesis, stabilizing arterial structure by regulating proliferation and organization of vascular smooth muscle. Elastin Protein, Mouse, Recombinant (His) is expressed in E. coli expression system with N-10xHis tag. The predicted molecular weight is 21.3 kDa and the accession number is P54320. | |||
TMPH-02253 |
TPM2 Protein, Human, Recombinant (His)
TPM2,Tropomyosin-2,Tropomyosin beta chain,Beta-tropomyosin |
Human | E. coli |
Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. The non-muscle isoform may have a role in agonist-mediated receptor internalization. | |||
TMPY-03983 |
CIRBP Protein, Human, Recombinant (His)
cold inducible RNA binding protein,CIRP |
Human | E. coli |
CIRBP, also known as cold-inducible RNA-binding protein, plays a protective role in the genotoxic stress response by stabilizing transcripts of genes involved in cell survival. CIRBP responds to a wide array of cellular stresses, including short wavelength ultraviolet light (UVC), at the transcriptional and post-translational level. It acts as a translational activator.CIRBP can bind the 3 translated region of specific transcripts to stabilize them and facilitate their transport to ribosomes for... | |||
TMPK-00937 |
CKAP4 Protein (Primary Amine Labeling), Human, Recombinant (His), Biotinylated
p63,CLIMP-63,ERGIC-63 |
Human | E. coli |
Cytoskeleton-associated protein 4 (CKAP4) is located in the rough endoplasmic reticulum (ER) and plays an important role in stabilizing the structure of ER. Meanwhile, CKAP4 is also found to act as an activated receptor at the cell surface. CKAP4 Protein (Primary Amine Labeling), Human, Recombinant (His), Biotinylated is expressed in E. coli expression system with N-His tag. The predicted molecular weight is 53.66 kDa and the accession number is Q07065. | |||
TMPH-02587 |
CIRBP Protein, Mouse, Recombinant (His)
CIRP,A18 hnRNP,Glycine-rich RNA-binding protein CIRP,CIRBP,C... |
Mouse | E. coli |
Cold-inducible mRNA binding protein that plays a protective role in the genotoxic stress response by stabilizing transcripts of genes involved in cell survival. Promotes assembly of stress granules (SGs), when overexpressed. Seems to play an essential role in cold-induced suppression of cell proliferation. Acts as a translational repressor. Acts as a translational activator. Binds specifically to the 3'-untranslated regions (3'-UTRs) of stress-responsive transcripts RPA2 and TXN. | |||
TMPH-02185 |
TEP1 Protein, Human, Recombinant (His)
p80 telomerase homolog,TEP1,Telomerase protein component 1,p... |
Human | E. coli |
Component of the telomerase ribonucleoprotein complex that is essential for the replication of chromosome termini. Also component of the ribonucleoprotein vaults particle, a multi-subunit structure involved in nucleo-cytoplasmic transport. Responsible for the localizing and stabilizing vault RNA (vRNA) association in the vault ribonucleoprotein particle. Binds to TERC. TEP1 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weigh... | |||
TMPH-03213 |
TPM1 Protein, Rabbit, Recombinant (E. coli, His & Myc)
Tropomyosin alpha-1 chain,TPM1,Alpha-tropomyosin,Tropomyosin... |
Rabbit | E. coli |
Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. TPM1 Protein, Rabbit, Recombinant (E. coli, His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular w... | |||
TMPH-03280 |
Dystrophin Protein, Rat, Recombinant (His)
Dystrophin,Dmd |
Rat | P. pastoris (Yeast) |
Anchors the extracellular matrix to the cytoskeleton via F-actin. Ligand for dystroglycan. Component of the dystrophin-associated glycoprotein complex which accumulates at the neuromuscular junction (NMJ) and at a variety of synapses in the peripheral and central nervous systems and has a structural function in stabilizing the sarcolemma. Also implicated in signaling events and synaptic transmission. Dystrophin Protein, Rat, Recombinant (His) is expressed in yeast with C-6xHis tag. The predicted... | |||
TMPH-02738 |
IRAK3 Protein, Mouse, Recombinant (His & Myc)
Irak3,Inactive IL-1 receptor-associated kinase 3,IL-1 recept... |
Mouse | Baculovirus Insect Cells |
Putative inactive protein kinase which regulates signaling downstream of immune receptors including IL1R and Toll-like receptors. Inhibits dissociation of IRAK1 and IRAK4 from the Toll-like receptor signaling complex by either inhibiting the phosphorylation of IRAK1 and IRAK4 or stabilizing the receptor complex. Upon IL33-induced lung inflammation, positively regulates expression of IL6, CSF3, CXCL2 and CCL5 mRNAs in dendritic cells. IRAK3 Protein, Mouse, Recombinant (His & Myc) is expressed in ... | |||
TMPY-03865 |
EB3 Protein, Human, Recombinant (His)
microtubule-associated protein, RP/EB family, member 3,EB3,R... |
Human | E. coli |
MAPRE3 (Microtubule Associated Protein RP/EB Family Member 3, also known as EB3) is a Protein Coding gene. 2 alternatively spliced human isoforms have been reported. MAPRE3 is a member of the RP/EB family. It localizes to the cytoplasmic microtubule network and binds APCL. MAPRE3 regulates the dynamics of the microtubule cytoskeleton and promotes microtubule growth. It may be involved in spindle function by stabilizing microtubules and anchoring them at centrosomes. MAPRE3 may also play a role i... | |||
TMPY-04025 |
CEP57 Protein, Human, Recombinant (GST)
MVA2,PIG8,TSP57,centrosomal protein 57kDa |
Human | E. coli |
CEP57 is a centrosomal protein and is involved in nucleating and stabilizing microtubules. CEP57 was initially identified as a regulator of centriole overduplication in an RNA interference screen. There is a link between altered microenvironmental signaling cues such as FGF-2 overexpression and mitotic instability and provide a rationale for the therapeutic targeting of the FGF-2/FGFR1/CEP57 axis in prostate cancer. CEP57 is involved in intracellular transport processes, and its overexpression c... | |||
TMPJ-01078 |
TFF2 Protein, Human, Recombinant (His)
SP,TFF2,Spasmolytic Polypeptide,Spasmolysin,SML1,Trefoil Fac... |
Human | HEK293 Cells |
Trefoil Factor 2 (TFF2) is a member of the trefoil family and contains two P-type (trefoil) domains. Members of this family are characterized by having at least one copy of the trefoil motif, a 40-amino acid domain that contains three conserved disulfides. TFF2 is a secreted protein and specifically expressed in the stomach. TFF2 inhibits gastrointestinal motility and gastric acid secretion. TFF2 could function as a structural component of gastric mucus, possibly by stabilizing glycoproteins in ... | |||
TMPJ-00775 |
CD74 Protein, Mouse, Recombinant (mFc & His)
HLA class II histocompatibility antigen γ chain,HLA-DR antig... |
Mouse | HEK293 Cells |
Mouse HLA class II histocompatibility antigen gamma chain (CD74), is a single-pass type II membrane protein that in humans is encoded by the CD74 gene. It contains 1 thyroglobulin type-1 domain. CD74 Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to compartments where peptide loading of class II takes place. | |||
TMPH-02974 |
Von Willebrand Factor/vWF Protein, Mouse, Recombinant (His & Myc)
Vwf,von Willebrand factor |
Mouse | E. coli |
Important in the maintenance of hemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet-surface receptor complex GPIb-IX-V. Also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilizing its heterodimeric structure and protecting it from premature clearance from plasma. Von Willebrand Factor/vWF Protein, Mouse, Recombinant (His & Myc) is expressed in E.... | |||
TMPJ-01079 |
TFF2 Protein, Mouse, Recombinant (His)
SP,Trefoil Factor 2,Spasmolytic polypeptide,Tff2,Sml1 |
Mouse | HEK293 Cells |
Recombinant Murine TFF-2 is an 11.9 kDa polypeptide of 106 amino acid residues, which includes a 40-amino acid trefoil motif containing three conserved intramolecular disulfide bonds. The Trefoil Factor peptides (TFF1, TFF2 and TFF3) are expressed in the gastrointestinal tract, and appear to play an important role in intestinal mucosal defense and repair. TFF2 has been shown to inhibit gastrointestinal motility and gastric acid secretion. Recent data suggests a potential role for TFF2 in acute a... | |||
TMPY-03600 |
TPM4 Protein, Human, Recombinant (His)
tropomyosin 4,HEL-S-108,TPM4 |
Human | HEK293 Cells |
TPM4, also known as tropomyosin 4, is a member of the tropomyosin family. Members of this family are actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. TPM4 is expressed in cardiac tissue and platelets. It is highly expressed in the platelets of hypertensive patients. TPM4 plays a central role, in association with the troponin complex, in the calcium-dependent regulation of vertebrate striated muscle contraction. Smo... | |||
TMPY-03059 |
Tubulin cofactor A Protein, Human, Recombinant
tubulin folding cofactor A |
Human | E. coli |
Tubulin folding cofactor A belongs to the TBCA family. It is one of four proteins (cofactors A, D, E, and C) involved in the early step of the tubulin folding pathway. These proteins can fold intermediates and finally lead to correctly folded beta-tubulin. It is believed that tubulin folding cofactors A and D play a role in capturing and stabilizing beta-tubulin intermediates in a quasi-native confirmation. Tubulin folding cofactor E binds to the cofactor D/beta-tubulin complex; interaction with... | |||
TMPH-00559 |
30S ribosomal protein S15 Protein, E. coli, Recombinant (His)
Small ribosomal subunit protein uS15,30S ribosomal protein S... |
E. coli | E. coli |
One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA. Binds to its own mRNA, stabilizing it 5-UTR and preventing its translation.; In the E.coli 70S ribosome it has been modeled to contact the 23S rRNA of the 50S subunit forming part of bridge B4. In the two 3.5 A resolved ribosome structures there are minor differences between side-chain conformation... | |||
TMPH-03578 |
SCIN Protein, S. aureus, Recombinant (His & Myc)
scn,Staphylococcal complement inhibitor |
Staphylococcus aureus | E. coli |
Involved in countering the first line of host defense mechanisms. Efficiently inhibits opsonization, phagocytosis and killing of S.aureus by human neutrophils. Acts by binding and stabilizing human C3 convertases (C4b2a and C3bBb), leading to their inactivation. The convertases are no longer able to cleave complement C3, therefore preventing further C3b deposition on the bacterial surface and phagocytosis of the bacterium. Also prevents C5a-induced neutrophil responses. SCIN Protein, S. aureus, ... | |||
TMPH-01662 |
Merlin Protein, Human, Recombinant (His)
Merlin,Moesin-ezrin-radixin-like protein,Schwannomin,Neurofi... |
Human | E. coli |
Probable regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in tumor suppression by restricting proliferation and promoting apoptosis. Along with WWC1 can synergistically induce the phosphorylation of LATS1 and LATS2 and can probably function in the regulation of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway. May act as a membrane stabilizing protein. May inhibit PI3 kinase by binding to AGAP2 and impairing its stimulating activity. Suppress... | |||
TMPY-06810 |
SFTPB Protein, Human, Recombinant (His)
SFTP3,SMDP1,PSP-B,SFTB3,SP-B |
Human | CHO Cells |
Pulmonary surfactant-associated protein B, also known as SFTPB and SP-B, contains one saposin A-type domain and three saposin B-type domains. SP-B is produced primarily by alveolar type II cells (AEC2) but also by nonciliated respiratory epithelial cells lining distal portions of the respiratory tract. Its secretion promotes alveolar homeostasis, stabilizing lipid layers and lowering surface tension at the air-liquid interface in the peripheral air spaces. Alveolar SP-B influences surfactant for... | |||
TMPY-03395 |
PC4/SUB1 Protein, Human, Recombinant (His)
PC4,RPO2TC1,SUB1 homolog, transcriptional regulator,p14,SUB1... |
Human | E. coli |
SUB1 belongs to the transcriptional coactivator PC4 family. It is a general coactivator that functions cooperatively with TAFs and mediates functional interactions between upstream activators and the general transcriptional machinery. SUB1 binds single-stranded DNA. Single-stranded DNA-binding proteins play many roles in nucleic acid metabolism, but their importance during transcription remains unclear. SUB1 exhibits strong genetic interactions with factors necessary for promoter melting. It loc... | |||
TMPH-01282 |
ELAVL4 Protein, Human, Recombinant (His & Myc & SUMO)
PNEM,ELAVL4,HuD,Hu-antigen D,ELAV-like protein 4 |
Human | E. coli |
RNA-binding protein that is involved in the post-transcriptional regulation of mRNAs. Plays a role in the regulation of mRNA stability, alternative splicing and translation. Binds to AU-rich element (ARE) sequences in the 3' untranslated region (UTR) of target mRNAs, including GAP43, VEGF, FOS, CDKN1A and ACHE mRNA. Many of the target mRNAs are coding for RNA-binding proteins, transcription factors and proteins involved in RNA processing and/or neuronal development and function. By binding to th... | |||
TMPH-02846 |
BICD2 Protein, Mouse, Recombinant (GST)
Bicd2,Kiaa0699,Bic-D 2,Protein bicaudal D homolog 2 |
Mouse | E. coli |
Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non-processive to a highly processive motor in the presence of dynactin. Facilitates and stabilizes the interaction between dynein and dynactin and activates dynein processivity (the ability to move along a microtubule for a long distance without falling off the track). Facilitates the binding of RAB6A to the Golgi by stabilizing its GTP-bound form. Regulates coat complex coatomer protein I (... | |||
TMPY-03981 |
CPLX3 Protein, Human, Recombinant (His)
CPXIII,Nbla11589,CPX-III,complexin 3 |
Human | HEK293 Cells |
CPLX3, also known as complexin 3, belongs to the complexin/synaphin family. As a SNARE-binding protein, complexin (CPX), can act either as a facilitator or as an inhibitor of membrane fusion, constituting a controversial dilemma. CPX acts sequentially on assembling SNAREpins, first facilitating zippering by nearly doubling the distance at which v- and t-SNAREs can engage and then clamping them into a half-zippered fusion-incompetent state. Specifically, the central helix of CPX allows SNAREs to ... | |||
TMPJ-00535 |
F13A Protein, Human, Recombinant (His)
F13A1,Coagulation Factor XIII A Chain,Transglutaminase A Cha... |
Human | HEK293 Cells |
Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of 2 A subunits and 2 B subunits. The A subunits have catalytic function, and the B subunits do not have enzymatic activity and may serve as plasma carrier molecules. Platelet factor XIII is composed of just 2 A subunits, which are identical to those of plasma origin. Upon cleavage of the activation peptide by thrombin and in the presence of calcium io... | |||
TMPH-02315 |
XRCC5 Protein, Human, Recombinant (His & Myc)
ATP-dependent DNA helicase 2 subunit 2,XRCC5,Ku86,Nuclear fa... |
Human | E. coli |
Single-stranded DNA-dependent ATP-dependent helicase that plays a key role in DNA non-homologous end joining (NHEJ) by recruiting DNA-PK to DNA. Required for double-strand break repair and V(D)J recombination. Also has a role in chromosome translocation. The DNA helicase II complex binds preferentially to fork-like ends of double-stranded DNA in a cell cycle-dependent manner. It works in the 3'-5' direction. During NHEJ, the XRCC5-XRRC6 dimer performs the recognition step: it recognizes and bind... | |||
TMPH-02314 |
XRCC5 Protein, Human, Recombinant (His & MBP)
Nuclear factor IV,Lupus Ku autoantigen protein p86,ATP-depen... |
Human | Baculovirus Insect Cells |
Single-stranded DNA-dependent ATP-dependent helicase that plays a key role in DNA non-homologous end joining (NHEJ) by recruiting DNA-PK to DNA. Required for double-strand break repair and V(D)J recombination. Also has a role in chromosome translocation. The DNA helicase II complex binds preferentially to fork-like ends of double-stranded DNA in a cell cycle-dependent manner. It works in the 3'-5' direction. During NHEJ, the XRCC5-XRRC6 dimer performs the recognition step: it recognizes and bind... |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T14687 |
Deucravacitinib
BMS-986165 |
Tyrosine Kinases; JAK; IFNAR; Interleukin | Angiogenesis; Chromatin/Epigenetic; Immunology/Inflammation; JAK/STAT signaling; Stem Cells; Tyrosine Kinase/Adaptors |
Deucravacitinib (BMS-986165) 是一种高选择性、口服生物可利用的变构 TYK2 抑制剂,用于治疗自身免疫性疾病。它通过稳定调节 JH2 结构域来阻断受体介导的 Tyk2 激活,可抑制IL-12/23和 I 型IFN 途径。它选择性结合 TYK2 假激酶 (JH2) 结构域,IC50为1.0 nM。 | |||
TMID-0245 |
Pindolol-d7
|
||
Pindolol-d7 是 Pindolol 的氘代化合物。Pindolol 的 CAS 号为 13523-86-9。Pindolol 是一种非选择性β-阻断剂,局部的β-肾上腺素能受体激动剂活性,也作为5-HT1A受体部分拮抗剂,Ki为33nM。它是非心脏选择性的,具有内在的拟交感神经作用。 | |||
TMIJ-0465 |
Triclosan methyl-d3 (methoxy-d3)
|
||
Triclosan methyl-d3 (methoxy-d3) 是 Triclosan methyl 的氘代化合物。Triclosan methyl 的 CAS 号为 4640-01-1。 | |||
TMIH-0091 |
AOH-d3
|
||
AOH-d3 是 AOH 的氘代化合物。AOH 的 CAS 号为 2089314-64-5。AOH1996 是一种具有口服活性的复制体组分 PCNA (增殖细胞核抗原) 配体,靶向转录-复制冲突 (TRC)。AOH1996 可干扰 PCNA 与其结合蛋白的相互作用,导致 DNA 复制应激,诱导细胞凋亡 (apoptosis)。AOH1996 通过稳定 PCNA 和 RNA 聚合酶 II 的相互作用从而导致蛋白酶体依赖的 rpb1 降解和致命的 DNA 损伤。AOH1996 与 DNA 损伤剂具有协同作用,可抑制肿瘤细胞生长。 | |||
TMIH-0025 |
13C-d3-AOH1996
|
||
13C-d3-AOH1996 是 AOH1996 的 13C 和氘代化合物。AOH1996 的 CAS 号为 2089314-64-5。AOH1996 是一种具有口服活性的复制体组分 PCNA (增殖细胞核抗原) 配体,靶向转录-复制冲突 (TRC)。AOH1996 可干扰 PCNA 与其结合蛋白的相互作用,导致 DNA 复制应激,诱导细胞凋亡 (apoptosis)。AOH1996 通过稳定 PCNA 和 RNA 聚合酶 II 的相互作用从而导致蛋白酶体依赖的 rpb1 降解和致命的 DNA 损伤。AOH1996 与 DNA 损伤剂具有协同作用,可抑制肿瘤细胞生长。 | |||
TMID-0166 |
Thymine-d4
|
||
Thymine-d4 是 Thymine 的氘代化合物。Thymine 的 CAS 号为 65-71-4。Thymine 是 DNA 的四个碱基之一,在动物癌症模型中,能够作为5-氟尿嘧啶的靶标,其 Km=2.3 μM。 | |||
TMID-0078 |
Irinotecan-d10 Hydrochloride
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Irinotecan-d10 Hydrochloride 是 Irinotecan Hydrochloride 的氘代化合物。Irinotecan Hydrochloride 的 CAS 号为 100286-90-6。Irinotecan Hydrochloride 是喜树碱半合成衍生物的盐酸盐,是一种拓扑异构酶 I 抑制剂,可研究结肠癌和直肠癌。 |