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SQA1 是方酰胺 (SQA) 衍生物,作为CCR6拮抗剂,其Kd为250 nM。同时,SQA1 也是CXCR2抑制剂。它占据了与G蛋白结合位点重叠的细胞内口袋,并稳定了该口袋的封闭构象。
SQA1 是方酰胺 (SQA) 衍生物,作为CCR6拮抗剂,其Kd为250 nM。同时,SQA1 也是CXCR2抑制剂。它占据了与G蛋白结合位点重叠的细胞内口袋,并稳定了该口袋的封闭构象。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
10 mg | 询价 | 10-14周 | |
50 mg | 询价 | 10-14周 |
产品描述 | SQA1 is a derivative of a phthalamide (SQA) and acts as a CCR6 antagonist with a Kd of 250 nM, as well as a CXCR2 inhibitor. It occupies an intracellular pocket that overlaps with the G protein binding site, stabilizing the pocket's closed conformation. |
分子量 | 426.47 |
分子式 | C22H26N4O5 |
CAS No. | 1255915-27-5 |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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