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Cat. No. | Product Name | Target | Signaling Pathways |
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T0106 |
Methazolamide
L584601,醋甲唑胺,CL 8490 |
Carbonic Anhydrase | Metabolism |
Methazolamide (CL 8490) 是一种磺胺衍生物,用作碳酸酐酶 (carbonic anhydrase) 抑制剂,对人 carbonic anhydrase II 的 Ki=为 14 nM。它是降低眼压的药物,能够抑制由青光眼及其他眼病引起的眼压升高的作用。 | |||
T4661 |
PKG drug G1
|
PKA | Tyrosine Kinase/Adaptors |
PKG drug G1 靶向作用于PKG Iα。它通过 C42 PKGIα 非依赖性机制,促进血管舒张以及血压降低。 | |||
T12478L |
Pinacidil
吡那地尔,S 1230,P 1134,S-1230,P-1134,P1134 |
Potassium Channel | Membrane transporter/Ion channel |
Pinacidil (P 1134) 是钾通道的有效激活剂。Pinacidil 通过打开 K+-通道使血管平滑肌超极化,显示出抗高血压活性。它显著改善再灌注功能和心脏顺应性。它具有直接的心脏保护作用。 | |||
T15718 |
Latanoprost acid
|
GPR | Endocrinology/Hormones; GPCR/G Protein |
Latanoprost acid 是前列腺素受体的选择性激动剂,通过抑制 c-fos/NFATc1 通路抑制 RANKL 诱导的破骨细胞生成和功能。 拉坦前列素酸可用于降低眼内压力的研究。 | |||
T26453 |
A 81282
A81282,A-81282,Abbott 81282,Abbott-81282 |
Others | Others |
A 81282 is a selective antagonist of angiotensin receptors. It has the activity of lowering blood pressure. | |||
T25482 |
H-0104 Dihydrochloride
H0104 Dihydrochloride,H0104 2HCl,H 0104 Dihydrochloride,H 0104 2HCl,H-0104 2HCl |
Others | Others |
H-0104 Dihydrochloride is an inhibitor of ROCK that acts by applying potent intraocular pressure (IOP)-lowering effects into the eyes of monkeys. | |||
T25483 |
H-0106 Dihydrochloride
H 0106 2HCl,H0106 2HCl,H0106 Dihydrochloride |
Others | Others |
H-0106 Dihydrochloride is an inhibitor of ROCK that acts by applying strong intraocular pressure (IOP)-lowering effects into the eyes of monkeys. | |||
T81915 |
LPP Tripeptide
|
||
LPP Tripeptide 是一种降血压作用的三肽,常用于高血压的研究领域。 | |||
T76499 |
Lactalbumin B (50-53) Alpha [Lactorphin Alpha], bovine
|
||
Lactalbumin B (50-53) Alpha [Lactorphin Alpha], bovine 是一种含有4个氨基酸构成的降血压肽,具有血管紧张素转换酶 (ACE) 抑制作用,适用于高血压研究。 | |||
T68098 |
Midaglizole
(±)-DG5128 free base,DG5128 free base,(±)-DG5128 free base ; DG5128 free base |
Others | Others |
Midaglizole ((±)-DG5128 free base, DG5128 free base) 是一种有效的α2-adrenoceptor 拮抗剂。Midaglizole 是一种降血糖药。Midaglizole 在具有升高血压并降低血糖水平的作用。 | |||
T39063 |
Azilsartan mepixetil
|
Others | Others |
Azilsartan mepixetil is a potent angiotensin II receptor antagonist with enhanced efficacy and prolonged duration of action. It exhibits more prominent and sustained effects in lowering blood pressure and heart rate, while maintaining a high level of safety. Furthermore, Azilsartan mepixetil demonstrates optimal protective efficacy for cardiovascular and renal functions. Hence, it holds promise for the research and treatment of hypertension, chronic heart failure, and diabetic nephropathy. | |||
T16388 |
Omidenepag isopropyl
|
Prostaglandin Receptor | GPCR/G Protein; Immunology/Inflammation |
Omidenepag isopropyl is converted to the active product Omidenepag during corneal penetration. Omidenepag isopropyl is a selective EP2 receptor agonist. Omidenepag isopropyl displays only a weak affinity for EP1, EP2, and FP receptors. Omidenepag isopropy | |||
T78624 |
OPC-163493
|
Reactive Oxygen Species | Immunology/Inflammation; Metabolism; NF-κB |
OPC-163493 是一种口服活性的肝脏靶向线粒体解偶联剂,能够减少 Δψ 及线粒体 ROS 生成。它展现了抗糖尿病与心血管益处,可在中风/高血压大鼠模型中降低血压、延长存活时间并改善肾脏功能。 | |||
T72213 |
Efonidipine hydrochloride
NZ-105 hydrochloride |
Others | Others |
Efonidipine(NZ-105)盐酸盐是T 型和L 型钙离子通道双重阻断剂。 | |||
T84551 |
N-Arachidonoyl-L-Serine
ARA-S |
Others | Others |
N-Arachidonoyl-L-serine (ARA-S), a recently isolated endocannabinoid with a distinct activity profile that diverges from typical endocannabinoids, does not interact with central cannabinoid (CB1), peripheral cannabinoid (CB2) receptors, or vanilloid receptor 1 (VR1). Unlike other compounds, ARA-S (5 mg/kg) counteracts the lowering of blood pressure induced by a 10 mg/kg intravenous bolus of abnormal cannabidiol (Abn-CBD) in anesthetized rat models. Additionally, akin to Abn-CBD, ARA-S induces re... |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T0022 |
Taurine
牛磺酸,2-Aminoethanesulfonic acid |
LDL; Endogenous Metabolite; Autophagy | Autophagy; Metabolism |
Taurine (2-Aminoethanesulfonic acid) 是一种含硫氨基酸的有机渗透剂,为胆汁盐的形成提供底物,并在调节细胞内游离钙浓度方面发挥作用,有激活脂肪细胞自噬的能力。 | |||
T2782L |
Catharanthine Tartrate(2468-21-5(free base))
|
Calcium Channel | Membrane transporter/Ion channel; Metabolism |
Catharanthine Tartrate(2468-21-5(free base)) 是从马达加斯加长春花中分离得到的天然产物,Catharanthine Tartrate 抑制电压操作的L 型Ca2+通道,具有抗癌和降血压活性。 | |||
T6S0654 |
Isocorynoxeine
7-Isocorynoxeine,异去氢钩藤碱 |
5-HT Receptor | GPCR/G Protein; Neuroscience |
Isocorynoxeine (7-Isocorynoxeine) 是钩藤中的一种生物碱,剂量依赖性抑制5-HT2A 受体介导的电流反应,IC50为 72.4 μM。 | |||
T3744 |
Veratric acid
Veratrumenoic acid,藜芦酸,3,4-Dimethoxybenzoic acid |
Reactive Oxygen Species; COX | Immunology/Inflammation; Metabolism; Neuroscience; NF-κB |
Veratric acid (3,4-Dimethoxybenzoic acid) 是从蔬菜和水果中得到的一种可口服多酚,具有抗氧化、保护心血管和抗炎活性。当细胞受到 UVB 辐射时,它能够减少上调的 COX-2 表达,降低 PGE2 和 IL-6 水平。 | |||
T3332 |
Isosteviol
异甜菊醇,(-)-Isosteviol |
IL Receptor; Potassium Channel; TNF; NF-κB; Reactive Oxygen Species; COX; Topoisomerase | Apoptosis; DNA Damage/DNA Repair; Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism; Neuroscience; NF-κB |
Isosteviol ((-)-Isosteviol) 是一种常见的天然甜味剂,属于四环二萜糖苷,是甜菊糖苷通过酸催化水解产生的。它抑制 DNA 聚合酶和 DNA 拓扑异构酶,具有抗菌、抗癌和抗结核作用。 | |||
TN2350 | Pingpeimine A | Others | Others |
Pingpeimine A has the effect of expectorating and lowering blood pressure. Derived from Fritillaria sibiricum. |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPH-01979 |
SFTPB Protein, Human, Recombinant
SFTPB,Pulmonary surfactant-associated protein B,6 kDa protei... |
Human | P. pastoris (Yeast) |
Pulmonary surfactant-associated proteins promote alveolar stability by lowering the surface tension at the air-liquid interface in the peripheral air spaces. SP-B increases the collapse pressure of palmitic acid to nearly 70 millinewtons per meter. SFTPB Protein, Human, Recombinant is expressed in yeast. The predicted molecular weight is 8.7 kDa and the accession number is P07988. |