|
TMPY-02801
|
PHGDH Protein, Human, Recombinant (His)
phosphoglycerate dehydrogenase,HEL-S-113,3PGDH,NLS1,PHGDHD,P...
|
Human
|
E. coli
|
|
PHGDH is a member of the D-isomer specific 2-hydroxyacid dehydrogenase family. This new family consists of D-isomer-stereospecific enzymes. The conserved residues in this family appear to be the residues involved in the substrate binding and the catalytic reaction, and thus to be targets for site-directed mutagenesis. A number of NAD-dependent 2-hydroxyacid dehydrogenases which seem to be specific for the D-isomer of their substrate have been shown to be functionally and structurally related. PH... |
|
TMPY-02603
|
STAT6 Protein, Human, Recombinant (His)
STAT6C,IL-4-STAT,STAT6B,signal transducer and activator of t...
|
Human
|
Baculovirus Insect Cells
|
|
Signal transducer and activator of transcription 6 (STAT6) is a transcription factor that is activated by interleukin-4 (IL-4)-induced tyrosine phosphorylation and mediates most of the IL-4-induced gene expression. STAT6 plays a central role in exerting interleukin-4 (IL-4) mediated biological responses and is found to induce the expression of BCL2L1/BCL-XL, which is responsible for the anti-apoptotic activity of IL4. Transcriptional activation by STAT6 requires the interaction with coactivators... |
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TMPY-04572
|
MKK4 Protein, Mouse, Recombinant (His & GST)
MKK4,MEK4,PRKMK4,Sek1,JNKK1,Serk1,mitogen-activated protein ...
|
Mouse
|
Baculovirus Insect Cells
|
|
Dual specificity mitogen-activated protein kinase kinase 4, also known as MAP kinase kinase 4, MAPKK4, JNK-activating kinase 1, MAPK/ERK kinase 4, SAPK/ERK kinase 1, c-Jun N-terminal kinase kinase 1, JNKK, and MAP2K4, is a protein that belongs to the protein kinase superfamily, STE Ser/Thr protein kinase family and MAP kinase kinase subfamily. MAP2K4 / JNKK1 is a protein kinase that is a direct activator of MAP kinases in response to various environmental stresses or mitogenic stimuli. MAP2K4 / ... |
|
TMPH-03048
|
LpxA Protein, MenC, Recombinant (His)
lpxA,Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-...
|
MenB
|
E. coli
|
|
Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. |
|
TMPJ-00726
|
NEO Protein, K. pneumoniae, Recombinant
Kanamycin kinase type II,Neomycin-kanamycin phosphotransfera...
|
Klebsiella pneumoniae
|
E. coli
|
|
Aminoglycoside 3'-phosphotransferase (APH(3')), also known as aminoglycoside kinase, is an aminoglycoside-modifying enzyme and widely presented in resistant bacteria. These ATP-dependent enzymes phosphorylate the 3'-hydroxyl of a variety of aminoglycosides including kanamycins, neomycins, paromomycins, neamine, ribostamycin, geneticin, and paromamine. These phosphorylated aminoglycosides fail to bind to their respective ribosomal binding sites with high affinity; hence resistance is conferred to... |
|
TMPY-02592
|
Annexin VI/ANXA6 Protein, Human, Recombinant (His)
ANX6,annexin A6,CBP68
|
Human
|
E. coli
|
|
Annexin A6, also known as ANXA6 or ANXAⅥ, belongs to a family of Ca2+-dependent membrane and phospholipid binding proteins. Members of this family have been implicated in membrane-related events along exocytotic and endocytotic pathways. Annexin 6 is phosphorylated in vivo associated with cell growth. Annexin 6 was not phosphorylated in quiescent cells, but was phosphorylated on serine and to a lesser extent threonine, several hours following cell stimulation. Experiment has revealed the presenc... |
|
TMPH-03391
|
TRIM2 Protein, Rat, Recombinant (His)
Trim2,Tripartite motif-containing protein 2,E3 ubiquitin-pro...
|
Rat
|
E. coli
|
|
E3 ubiquitin-protein ligase that mediates the ubiquitination of phosphorylated BCL2L11. Also mediates the UBE2D1-dependent ubiquitination of NEFL. Plays a neuroprotective function. May play a role in neuronal rapid ischemic tolerance. TRIM2 Protein, Rat, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 85.5 kDa and the accession number is D3ZQG6. |
|
TMPY-02240
|
STAT1 Protein, Human, Recombinant (His & GST)
IMD31A,IMD31B,IMD31C,STAT91,CANDF7,signal transducer and act...
|
Human
|
Baculovirus Insect Cells
|
|
STAT1 is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor-associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. STAT1 can be activated by various ligands, including interferon-alpha, interferon-gamma, EGF, PDGF and IL6. It is a signal transducer and transcription activator that mediates cellular responses to interferons (IFNs),... |
|
TMPY-03599
|
RPRD1B Protein, Human, Recombinant (His)
C20orf77,regulation of nuclear pre-mRNA domain containing 1B...
|
Human
|
HEK293 Cells
|
|
RPRD1B, together with RPRD1A, can accompany RNAP II from promoter regions to 3'-untranslated regions during transcription in vivo, predominantly interact with phosphorylated RNAP II, and can reduce CTD S5- and S7-phosphorylated RNAP II at target gene promoters. RNA polymerase II C-terminal domain (CTD) phosphorylation is important for various transcription-related processes. RPRD1B is a transcriptional regulator that enhances expression of CCND1. It also enhances the transcription of a number of... |
|
TMPH-02651
|
Fbxo3 Protein, Mouse, Recombinant (His & Myc)
Muscle atrophy F-box protein,Atrogin-1,Fbxo32,F-box only pro...
|
Mouse
|
E. coli
|
|
Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins during skeletal muscle atrophy. Recognizes TERF1. |
|
TMPJ-01050
|
GRB2 Protein, Human, Recombinant (His)
Growth Factor Receptor-Bound Protein 2,SH2/SH3 Adapter GRB2,...
|
Human
|
E. coli
|
|
As an adaptor protein, Growth Factor Receptor-Bound Protein 2 (GRB2) is involved in siganl transduction and consists of a central SH2 domain flanked by two SH3 domains. GRB2 associates with activated Tyr-phosphorylated EGF receptor/EGFR and PDGF receptors via its SH2 domain, stimulating GTP binding to Ras, which in turn activates MAPK and other signaling pathway.It also associates to other cellular Tyr-phosphorylated proteins such as SIT1, IRS1, IRS4, SHC and LNK. probably via the concerted acti... |
|
TMPY-03291
|
SMAD2 Protein, Mouse, Recombinant (His & GST)
mMad2,Smad-2,7120426M23Rik,Madr2,Madh2,SMAD family member 2
|
Mouse
|
Baculovirus Insect Cells
|
|
SMAD2 is a member of the SMAD family. Members of this family mediate signal transduction by the TGF-beta/activin/BMP-2/4 cytokine superfamily from receptor Ser/Thr protein kinases at the cell surface to the nucleus. SMAD2 mediates the signal of the TGF-beta, and therefore regulates multiple cellular processes, such as cell proliferation, apoptosis, and differentiation. SMAD2 is recruited to the TGF-beta receptors through its interaction with the SMAD anchor for receptor activation (SARA) protein... |
|
TMPH-03375
|
Stathmin-2 Protein, Rat, Recombinant (His)
Superior cervical ganglion-10 protein,Stmn2,Stathmin-2
|
Rat
|
E. coli
|
|
Regulator of microtubule stability. When phosphorylated by MAPK8, stabilizes microtubules and consequently controls neurite length in cortical neurons. In the developing brain, negatively regulates the rate of exit from multipolar stage and retards radial migration from the ventricular zone. Stathmin-2 Protein, Rat, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 26.7 kDa and the accession number is P21818. |
|
TMPH-00318
|
LpxD Protein, Burkholderia pseudomallei, Recombinant (His & Myc)
lpxD,UDP-3-O-acylglucosamine N-acyltransferase
|
Burkholderia pseudomallei
|
E. coli
|
|
Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. LpxD Protein, Burkholderia pseudomallei, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 44.2 kDa and the accession number is A3NAT7. |
|
TMPH-01694
|
MLKL Protein, Human, Recombinant (E. coli, His)
MLKL,Mixed lineage kinase domain-like protein
|
Human
|
E. coli
|
|
Pseudokinase that plays a key role in TNF-induced necroptosis, a programmed cell death process. Does not have protein kinase activity. Activated following phosphorylation by RIPK3, leading to homotrimerization, localization to the plasma membrane and execution of programmed necrosis characterized by calcium influx and plasma membrane damage. In addition to TNF-induced necroptosis, necroptosis can also take place in the nucleus in response to orthomyxoviruses infection: following activation by ZB... |
|
TMPH-01578
|
KRT18 Protein, Human, Recombinant (His)
Keratin, type I cytoskeletal 18,KRT18,Cell proliferation-ind...
|
Human
|
HEK293 Cells
|
|
Involved in the uptake of thrombin-antithrombin complexes by hepatic cells. When phosphorylated, plays a role in filament reorganization. Involved in the delivery of mutated CFTR to the plasma membrane. Together with KRT8, is involved in interleukin-6 (IL-6)-mediated barrier protection. |
|
TMPH-00078
|
Beta-amylase 1, chloroplastic Protein, Arabidopsis thaliana, Recombinant (His & Myc)
1,4-alpha-D-glucan maltohydrolase,TRBAMY,TR-BAMY,BMY7,Thiore...
|
Arabidopsis thaliana
|
E. coli
|
|
Beta-amylase activity. Can use p-nitrophenyl maltopentaoside (PNPG5) as substrate only in reduced form. Can play a minor role in the starch degradation and maltose metabolism in chloroplasts during the night. More active on phosphorylated glucan. Interacts directly with starch or other alpha-1,4-glucan. Beta-amylase 1, chloroplastic Protein, Arabidopsis thaliana, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 41.7 ... |
|
TMPH-02666
|
Fukutin Protein, Mouse, Recombinant (His & Myc)
Fktn,Fukutin,Ribitol-5-phosphate transferase FKTN,Fukuyama-t...
|
Mouse
|
E. coli
|
|
Catalyzes the transfer of CDP-ribitol to the distal N-acetylgalactosamine of the phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-3-N-acetylglucosamine-beta-4-(phosphate-6-)mannose), a carbohydrate structure present in alpha-dystroglycan (DAG1). This constitutes the first step in the formation of the ribitol 5-phosphate tandem repeat which links the phosphorylated O-mannosyl trisaccharide to the ligand binding moiety composed of repeats of 3-xylosyl-alpha-1,3-glucuronic acid-b... |
|
TMPH-03452
|
NDPK Protein, S. cerevisiae, Recombinant (His)
Nucleoside diphosphate kinase,YNK1
|
Saccharomyces cerevisiae
|
P. pastoris (Yeast)
|
|
Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Required for repair of UV radiation- and etoposide-induced DNA damage. NDPK Protein, S. cerevisiae, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 19.2 kDa and the accession number is P36010. |
|
TMPJ-01186
|
TRIM Protein, Human, Recombinant (His)
pp29/30,TRIM,HSPC062,TCRIM,TRAT1,T-Cell Receptor-Interacting...
|
Human
|
E. coli
|
|
T-Cell Receptor-Associated Transmembrane Adapter 1 (TRAT1) is a single-pass type III membrane protein. TRAT1 exists as a disulfide-linked homodimer and is strongly expressed in the thymus, and to a lesser extent in the spleen, lymph node, and peripheral blood lymphocytes. TRAT1 is phosphorylated on tyrosines by LCK or FYN upon TCR activation. Its function is to stabilizes the TCR (T-cell antigen receptor)/CD3 complex at the surface of T-cells. |
|
TMPJ-01178
|
TGFBR1 Protein, Mouse, Recombinant (hFc)
ALK-5,ALK-5ALK5,TGFβRI,tβR-I,LDS1A,TGFbetaRI,TGFB1R1,activin...
|
Mouse
|
HEK293 Cells
|
|
TGF-beta RI, also called ALK-5, is an approximately 55 kDa type I transmembrane serine/threonine receptor kinase. In the presence of TGF-beta, TGF-beta RI forms a complex with, and is phosphorylated by, TGF-beta RII. Phosphorylated TGF-beta RI can then transiently bind and phosphorylate Smad2 and Smad3. TGF-beta functions as a tumor suppressor by inhibiting the cell cycle in the G1 phase. Administration of TGF-beta is able to protect against mammary tumor development in transgenic mouse models i... |
|
TMPH-01021
|
BTN3A1 Protein, Human, Recombinant (E. coli, His)
CD277,Butyrophilin subfamily 3 member A1,BTN3A1,BTF5
|
Human
|
E. coli
|
|
Plays a role in T-cell activation and in the adaptive immune response. Regulates the proliferation of activated T-cells. Regulates the release of cytokines and IFNG by activated T-cells. Mediates the response of T-cells toward infected and transformed cells that are characterized by high levels of phosphorylated metabolites, such as isopentenyl pyrophosphate. BTN3A1 Protein, Human, Recombinant (E. coli, His) is expressed in E. coli expression system with N-10xHis tag. The predicted molecular wei... |
|
TMPH-02274
|
JAK2 Protein, Human, Recombinant (His)
JAK2,Janus kinase 2,Tyrosine-protein kinase JAK2
|
Human
|
E. coli
|
|
Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors such as growth hormone (GHR), prolactin (PRLR), leptin (LEPR), erythropoietin (EPOR), thrombopoietin (THPO); or type II receptors including IFN-alpha, IFN-beta, IFN-gamma and multiple int... |
|
TMPH-03451
|
NDPK Protein, S. cerevisiae, Recombinant (E. coli, His)
YNK1,Nucleoside diphosphate kinase
|
Saccharomyces cerevisiae
|
E. coli
|
|
Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Required for repair of UV radiation- and etoposide-induced DNA damage. NDPK Protein, S. cerevisiae, Recombinant (E. coli, His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 21.2 kDa and the accession number is P36010. |
|
TMPH-01703
|
CDC25C Protein, Human, Recombinant (His)
Dual specificity phosphatase Cdc25C,M-phase inducer phosphat...
|
Human
|
E. coli
|
|
Functions as a dosage-dependent inducer in mitotic control. Tyrosine protein phosphatase required for progression of the cell cycle. When phosphorylated, highly effective in activating G2 cells into prophase. Directly dephosphorylates CDK1 and activates its kinase activity. CDC25C Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 57.4 kDa and the accession number is P30307. |
|
TMPH-02060
|
SAG Protein, Human, Recombinant (His)
Retinal S-antigen,Rod photoreceptor arrestin,48 kDa protein,...
|
Human
|
P. pastoris (Yeast)
|
|
Binds to photoactivated, phosphorylated RHO and terminates RHO signaling via G-proteins by competing with G-proteins for the same binding site on RHO. May play a role in preventing light-dependent degeneration of retinal photoreceptor cells. SAG Protein, Human, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 47.1 kDa and the accession number is P10523. |
|
TMPH-00079
|
Beta-amylase 3, chloroplastic Protein, Arabidopsis thaliana, Recombinant (His)
BAM3,CTBMY,1,4-alpha-D-glucan maltohydrolase,Beta-amylase 3,...
|
Arabidopsis thaliana
|
E. coli
|
|
Beta-amylase activity. No alpha-amylase activity. Involved in cold resistance. Mediates the accumulation of maltose upon freezing stress, thus contributing to the protection of the photosynthetic electron transport chain. Plays a role in the circadian-regulated starch degradation and maltose metabolism in chloroplasts, especially at night. More active on phosphorylated glucan. Interacts directly with starch or other alpha-1,4-glucan. |
|
TMPH-02180
|
TTBK2 Protein, Human, Recombinant (His & Myc)
Tau-tubulin kinase 2,TTBK2
|
Human
|
E. coli
|
|
Serine/threonine kinase that acts as a key regulator of ciliogenesis: controls the initiation of ciliogenesis by binding to the distal end of the basal body and promoting the removal of CCP110, which caps the mother centriole, leading to the recruitment of IFT proteins, which build the ciliary axoneme. Has some substrate preference for proteins that are already phosphorylated on a Tyr residue at the +2 position relative to the phosphorylation site. Able to phosphorylate tau on serines in vitro. |
|
TMPJ-00675
|
ZNHIT1 Protein, Human, Recombinant (His)
ZNFN4A1,CGBP1,inc finger HIT domain-containing protein 1,cyc...
|
Human
|
E. coli
|
|
ZNHIT1 belongs to the ZNHIT1 family and contains one HIT-type zinc finger. It can be phosphorylated on Thr by MAPK11 or MAPK14. ZNHIT1 is a component of the chromatin-remodeling SRCAP complex, which is composed of at least SRCAP, DMAP, RUVBL1, RUVBL2, ACTL6A, YEATS4, ACTR6 and ZNHIT1. ZNHIT1 may play a role in p53-mediated apoptosis induction. |
|
TMPH-01020
|
BTN3A1 Protein, Human, Recombinant (Yeast, His)
Butyrophilin subfamily 3 member A1,BTN3A1,CD277,BTF5
|
Human
|
P. pastoris (Yeast)
|
|
Plays a role in T-cell activation and in the adaptive immune response. Regulates the proliferation of activated T-cells. Regulates the release of cytokines and IFNG by activated T-cells. Mediates the response of T-cells toward infected and transformed cells that are characterized by high levels of phosphorylated metabolites, such as isopentenyl pyrophosphate. BTN3A1 Protein, Human, Recombinant (Yeast, His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 26.2 kDa and the... |
|
TMPH-01577
|
KRT18 Protein, Human, Recombinant (E. coli, His)
Keratin-18,KRT18,Cytokeratin-18,Cell proliferation-inducing ...
|
Human
|
E. coli
|
|
Involved in the uptake of thrombin-antithrombin complexes by hepatic cells. When phosphorylated, plays a role in filament reorganization. Involved in the delivery of mutated CFTR to the plasma membrane. Together with KRT8, is involved in interleukin-6 (IL-6)-mediated barrier protection. KRT18 Protein, Human, Recombinant (E. coli, His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 52.0 kDa and the accession number is P05783. |
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TMPU-00003
|
STAT2 Protein, Human, Recombinant (His)
|
Human
|
E. coli
|
|
Signal transducer and activator of transcription that mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of... |
|
TMPJ-01241
|
DTD1 Protein, Human, Recombinant (His)
DUE-B,D-tyrosyl-tRNA(Tyr) deacylase 1,DNA-unwinding element-...
|
Human
|
HEK293 Cells
|
|
D-tyrosyl-tRNA(Tyr) deacylase 1(DTD1) belongs to the DTD family, and expressed in many adult and fetal tissues such as testis, ovary, spleen in adult and fetal brain. It is a nucleus and cytoplasm located protein, and is preferentially phosphorylated in cells arrested early in S phase. DTD1 is an ATPase involved in DNA replication, it may facilitate loading of CDC45 onto pre-replication complexes. The protein may hydrolyze D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr), a possible defens... |
|
TMPJ-00961
|
STAT1 Protein, Human, Recombinant
Transcription Factor ISGF-3 Components p91/p84,STAT1,Signal ...
|
Human
|
E. coli
|
|
Signal Transducer and Activator of Transcription 1-Alpha/Beta (STAT1) contains one SH2 domain and belongs to the transcription factor STAT family. When tyrosine- and serine-phosphorylated, STAT1 can form a homodimer termed IFN-gamma-activated factor (GAF), migrate into the nucleus and bind to the IFN gamma activated sequence (GAS) to drive the expression of the target genes, inducing a cellular antiviral state. STAT1 functions as signal transducer and transcription activator that mediates cellul... |
|
TMPJ-01110
|
IRF5 Protein, Human, Recombinant (His)
Interferon Regulatory Factor 5,IRF5,IRF-5
|
Human
|
E. coli
|
|
Interferon Regulatory Factor 5 (IRF5) is a member of the IRF family. It contains one IRF tryptophan pentad repeat DNA-binding domain. IRF5 shuttles between the nucleus and the cytoplasm. IRF5 can form homodimer when it is phosphorylated. IRF5 functions as a transcription factor involved in the induction of interferons IFNA and INFB and inflammatory cytokines upon virus infection. Genetic variations in IRF5 are associated with susceptibility to systemic lupus erythematosus type 10. In addition, ... |
|
TMPJ-00528
|
PPP1R1A Protein, Human, Recombinant (His)
PPP1R1A,I-1,IPP-1,Protein Phosphatase Inhibitor 1,Protein Ph...
|
Human
|
E. coli
|
|
Protein Phosphatase 1 Regulatory Subunit 1A (PPP1R1A) is an inhibitor of protein-phosphatase 1. PPP1R1A is a cellular regulator of eIF2 alpha phosphorylation. In hormonal control of glycogen metabolism, IPP-1 protein plays important function. Hormones can elevate intracellular cAMP level and elevate IPP-1 activity. PPP1R1A activation caused cAMP increase , cAMP control over proteins that are not directly phosphorylated by PKA following a rise in intracellular calcium. IPP-1 is inactivated by cal... |
|
TMPJ-00514
|
ACPP Protein, Human, Recombinant (His)
Ecto-5'-Nucleotidase,TMPase,5'-Nucleotidase,Thiamine Monopho...
|
Human
|
HEK293 Cells
|
|
Prostatic Acid Phosphatase (PAP) belongs to the histidine acid phosphatase family. PAP can catalyze the hydrolysis of member of phosphate monoestyers, including phosphorylated protein. PAP can high expression in metastasized prostate cancer, moderately expression level in bone diseases, blood cell disease, and the concentration of PAP is used to monitor and assess the proession of prostate cancer. The optimum PH of PAP is from 4 to 6; its activity can be inhibited by L(+)-tartrate. |
|
TMPY-00487
|
PTPN9 Protein, Human, Recombinant (His & GST)
PTPMEG2,protein tyrosine phosphatase, non-receptor type 9,ME...
|
Human
|
Baculovirus Insect Cells
|
|
Protein tyrosine phosphatase non-receptor type 9 (PTPN9), also named PTP-MEG2, is an important member of the protein tyrosine phosphatase family that is involved in variety of human diseases.PTPN9 plays an important role in erythropoiesis by disrupting an inhibitory complex of phosphorylated STAT3, GATA1 and ZBP-89, providing new cellular and molecular insights into the role of ptpn9a in developmental hematopoiesis. |
|
TMPY-02010
|
DMP1 Protein, Human, Recombinant (His)
ARHR,dentin matrix acidic phosphoprotein 1,ARHP,DMP-1
|
Human
|
HEK293 Cells
|
|
Dentin matrix acidic phosphoprotein (DMP1) is an extracellular matrix protein and a member of the small integrin binding ligand N-linked glycoprotein family. This protein, which is critical for proper mineralization of bone and dentin, is present in diverse cells of bone and tooth tissues. DMP1 contains a large number of acidic domains, multiple phosphorylation sites, a functional arg-gly-asp cell attachment sequence, and a DNA binding domain. In undifferentiated osteoblasts it is primarily a nu... |
|
TMPH-00099
|
NDK1 Protein, Arabidopsis thaliana, Recombinant (His & Myc)
Nucleoside diphosphate kinase 1,NDK1,Nucleoside diphosphate ...
|
Arabidopsis thaliana
|
P. pastoris (Yeast)
|
|
Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Plays a role in response to reactive oxygen species (ROS) stress. NDK1 Protein, Arabidopsis thaliana, Recombinant (His & Myc) is expressed in yeast with N-10xHis and C-Myc tag. The predicted molecular weight is 20.5 kDa and the accession number is P39207. |
|
TMPJ-00520
|
NANS Protein, Human, Recombinant (His)
N-Acetylneuraminic Acid Synthase,N-Acetylneuraminic Acid Pho...
|
Human
|
E. coli
|
|
Sialic Acid Synthase (NANS) is an enzyme that contains one AFP-like domain. NANS is ubiquitous and plays a role in the biosynthetic pathways of sialic acids. NANS produces N-acetylneuraminic acid (Neu5Ac) and 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid (KDN). It also can use N-acetylmannosamine 6-phosphate and mannose 6-phosphate as substrates to generate phosphorylated forms of Neu5Ac and KDN, respectively. |
|
TMPY-03216
|
GMF beta/GMFB Protein, Human, Recombinant
GMF β/GMFB,glia maturation factor, β,glia maturation factor,...
|
Human
|
E. coli
|
|
GMFB is a nerve growth factor which belongs to the actin-binding proteins ADF family, GMF subfamily. GMFB is involved in nervous system development, angiogenesis and immune function. It is especially crucial for the nervous system. GMFB causes brain cell differentiation, stimulates neural regeneration and inhibits tumor cell proliferation. It contains 1 ADF-H domain and is phosphorylated after phorbol ester stimulation. GMFB overexpression in astrocytes results in the increase of BDNF production... |
|
TMPJ-01307
|
PACSIN1 Protein, Human, Recombinant (His)
Protein Kinase C and Casein Kinase Substrate in Neurons Prot...
|
Human
|
HEK293 Cells
|
|
Protein Kinase C and Casein Kinase Substrate in Neurons Protein 1 (PACSIN1) belongs to the PACSIN family. PACSIN1 contains one FCH domain and one SH3 domain. PACSIN1 is highly expressed in the brain and at lower leves in the heart, pancreas, and liver. PACSIN1 may play a role in vesicle formation and transport. PACSIN1 has been shown to interact with DNM1, PACSIN3, Huntingtin, and PACSIN2. In addition, PACSIN1 is phosphorylated by casein kinase 2 (CK2) and protein kinase C (PKC). |
|
TMPJ-00240
|
CAMK1 Protein, Human, Recombinant (His)
CaM Kinase I Alpha,CaMKI-α,CaM Kinase I,CAMK1,Calcium/Calmod...
|
Human
|
HEK293 Cells
|
|
Calcium/Calmodulin-Dependent Protein Kinase Type 1 (CAMK1) belongs to the protein kinase superfamily, CAMK Ser/Thr protein kinase family, and CaMK subfamily. CAMK1 contains one protein kinase domain and widely expressed. CAMK1 is phosphorylated by CaMKK1 and CaMKK2 on Thr-177. CAMK1 regulates transcription activators activity, cell cycle, hormone production, cell differentiation, actin filament organization, and neurite outgrowth. CAMK1 plays a role in K+ and ANG2-mediated regulation of the aldo... |
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TMPH-02219
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JUN Protein, Human, Recombinant (His & Myc)
Proto-oncogene c-Jun,p39,V-jun avian sarcoma virus 17 oncoge...
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Human
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E. coli
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Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'. Promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. Involved in activated KRAS-mediated transcriptional activation of USP28 in colorectal cancer (CRC) cells. Binds to the USP28 promoter in colorectal cancer (CRC) cells. JUN Protein, Human, Recombinant (His & Myc) is expressed in E. coli expression system wi... |
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TMPY-03438
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Calsequestrin 1 Protein, Human, Recombinant
CASQ,PDIB1,VMCQA,calsequestrin 1 (fast-twitch, skeletal musc...
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Human
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E. coli
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Calsequestrin-1 is an isoform of calsequestrin. Calsequestrin is a calcium-binding protein of the sarcoplasmic reticulum. It helps hold calcium in the cisterna of the sarcoplasmic reticulum after a muscle contraction, even though the concentration of calcium in the sarcoplasmic reticulum is much higher than in the cytosol. Two forms of calsequestrin have been identified: Calsequestrin-2 and Calsequestrin-1. Calsequestrin-1 is found in fast skeletal muscle. The release of calsequestrin-boun... |
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TMPH-01752
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Nestin/NES Protein, Human, Recombinant (His)
Nestin,NES
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Human
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P. pastoris (Yeast)
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Required for brain and eye development. Promotes the disassembly of phosphorylated vimentin intermediate filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other cellular factors to daughter cells during progenitor cell division. Required for survival, renewal and mitogen-stimulated proliferation of neural progenitor cells. Nestin/NES Protein, Human, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 2... |
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TMPJ-01046
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RPS7 Protein, Human, Recombinant (His)
RPS7,40S ribosomal protein S7
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Human
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E. coli
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40S ribosomal protein S7(RPS7) belongs to the S7E family of ribosomal proteins. It is phosphorylated by NEK6 during post-translational modification. RPS7 is located in the cytoplasm, binds IPO9 with high affinity. it also can interacts with NEK6. As is required for rRNA maturation and typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. The unnormal expression of RPS7 may cause Diamond-Blackfan anemia 8. |
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TMPH-02218
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JUN Protein, Human, Recombinant (His)
p39,JUN,Transcription factor Jun,Transcription factor AP-1 s...
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Human
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Baculovirus Insect Cells
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Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'. Promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. Involved in activated KRAS-mediated transcriptional activation of USP28 in colorectal cancer (CRC) cells. Binds to the USP28 promoter in colorectal cancer (CRC) cells. JUN Protein, Human, Recombinant (His) is expressed in Baculovirus insect cells with C-6x... |
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TMPJ-00024
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GMF beta/GMFB Protein, Human, Recombinant (His)
GMF-β,GMF-beta,GMFB,Glia maturation factor beta,Glia maturat...
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Human
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E. coli
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Glia maturation factor beta (GMFB) contains a ADF-H domain，which is a member of the actin-binding proteins ADF family, GMF subfamily. It is a nerve growth factor implicated in nervous system development, angiogenesis and immune function. GMFB causes differentiation of brain cells, stimulation of neural regeneration, and inhibition of proliferation of tumor cells. It is phosphorylated after phorbol ester stimulation, and is crucial for the nervous system. GMFB overexpression in astrocytes results... |
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