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Search Results for " osteoarthritis "

Targets Recommended: COX

70

抑制剂 & 化合物

15

天然产物

1

化合物库

6

重组蛋白

2

同位素标记化合物

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Cat. No.	Product Name
L4710	非甾体类抗炎化合物库		530 compounds
	530 种非甾体类的抗炎相关化合物，可用于高通量和高内涵筛选；

化合物库

非甾体类抗炎化合物库

Cat.No: L4710

Compounds: 530

Cat. No.	Product Name	Target	Signaling Pathways
T2553	Etofenamate	COX	Immunology/Inflammation; Neuroscience
	Etofenamate 是非甾体类抗炎小分子，也是非选择性的 COX 抑制剂，具有抗风湿和解热抗炎作用，可用于缓解疼痛、关节炎等炎症相关疾病的研究。
T16124	MMP13-IN-3	MMP	Proteases/Proteasome
	MMP13-IN-3 是口服有效的MMP-13选择性抑制剂，IC50为 1 nM，比其他 MMP 的选择性高 1000倍多。MMP13-IN-3在用于骨关节炎方面有研究的价值。
T1748	Kartogenin KGN	TGF-beta/Smad	Stem Cells
	Kartogenin (KGN) 是一种人间充质干细胞分化为软骨细胞的诱导剂(EC50:100 nM)。它能够结合纤维蛋白 A，破坏其与转录因子核心结合因子 β 亚基 (CBFβ) 的相互作用，并通过调节 CBFβ-RUNX1 转录程序，诱导软骨形成，可用于研究骨关节炎。
T0291	Flurbiprofen 氟比洛芬,dl-Flurbiprofen	Apoptosis; COX; MRP	Apoptosis; Immunology/Inflammation; Neuroscience
	Flurbiprofen (dl-Flurbiprofen) 是一种高效的，具有口服活性的非甾体抗炎化合物，有退热止痛活性, 常用于炎症性疾病的研究。它是一种非选择性的环氧合酶抑制剂，可研究结肠癌。
T1421	Aceclofenac 醋氯芬酸,Preservex,Airtal	COX	Immunology/Inflammation; Neuroscience
	Aceclofenac (Preservex) 是一种可口服的非甾体抗炎药，可用于缓解疼痛、骨关节炎、强直性脊柱炎、类风湿性关节炎的研究。
T9977	SGK1-IN-4	SGK	Metabolism
	SGK1-IN-4 是 SGK1 的特异性抑制剂，可用于骨关节炎研究。
T9711	OGT-IN-2	Others	Others
	OGT-IN-2 是 OGT 抑制剂，抑制 sOGT 和 ncOGT 的 IC50分别为 30 μM 和 53 μM。它在关节疾病方面有研究的价值，如关节软骨疾病、骨关节炎。
T6574	Lumiracoxib Prexige,罗美昔布,COX-189	COX	Immunology/Inflammation; Neuroscience
	Lumiracoxib (Prexige) 是强选择性有口服活性的 COX-2抑制剂，Ki 值为 0.06 μM。它是非选择性非甾体抗炎试剂，具有抗炎和解热活性，可用于骨关节炎和骨癌研究。
T4561	Tiaprofenic acid Tiaprofensaeure,噻洛芬酸,Acido tiaprofenico,Surgam	Others; COX	Immunology/Inflammation; Neuroscience; Others
	Tiaprofenic acid (Acido tiaprofenico) 是可口服的非甾体抗炎药，通过抑制环氧化酶抑制前列腺素合成，可用于风湿性疾病的研究。
T4552	Fursultiamine Diteftin,呋喃硫胺,Judolor,Alinamin F	Others	Others
	Fursultiamine (Alinamin F) 是维生素 B1衍生物，具有抗伤害和抗肿瘤作用。它可用于研究维生素 B1缺乏病、骨关节炎和癌症。
T1780	Parecoxib SC 69124,帕瑞昔布,Vorth-P,Valus-P	COX	Immunology/Inflammation; Neuroscience
	Parecoxib (SC 69124) 是一种有效的选择性 COX-2 抑制剂，是 Valdecoxib 的前药。
T0859	Fenbufen 芬布芬,CL-82204,Lederfen	ATPase; Caspase; COX	Apoptosis; Immunology/Inflammation; Membrane transporter/Ion channel; Neuroscience; Proteases/Proteasome
	Fenbufen (Lederfen) 是一种非甾体抗炎药，主要用于治疗骨关节炎、强直性脊柱炎和肌腱炎的炎症。它还可用于缓解背痛、扭伤和骨折，具有 caspases 的抑制活性。它对 COX-1和 COX-2具有抑制活性，其 IC50分别为 3.9 μM 和 8.1 μM。
T5099	Gefapixant RO 4926219,AF219,MK-7264	P2X Receptor	Membrane transporter/Ion channel; Neuroscience
	Gefapixant (AF219) 是一个 P2X3 受体拮抗剂，其对人同源重组 hP2X3 和 hP2X2/3 的 IC50值分别是约 30 和 100-250 nM。
T11340	Furprofen	Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation
	Furprofen 是一种非甾体类抗炎剂，抑制前列腺 (PGE) 合成，可用于研究类风湿关节炎和骨关节炎。
T28394	PG-116800 PG-530742,PGE-7113313,PGE 7113313,PG 530742	MMP	Proteases/Proteasome
	PG-116800 (PG-530742) 是一种基质金属蛋白酶 (MMP) 抑制剂。 PG-116800 可用于骨关节炎治疗的研究。
T77502	Wnt pathway inhibitor 3	Wnt/beta-catenin; Adenylyl cyclase	Cytoskeletal Signaling; Neuroscience; Stem Cells
	Wnt pathway inhibitor 3 是一种有效的 AC1 抑制剂，IC50 值为 45 nM。Wnt pathway inhibitor 3 具有抗增殖活性，可用于研究改善实验性骨关节炎小鼠模型中的骨关节炎。
T1109	(Z)-Capsaicin Zucapsaicin,Civamide,cis-Capsaicin,珠卡赛辛,(Z)-辣椒素	TRP/TRPV Channel; HSV	Membrane transporter/Ion channel; Microbiology/Virology
	(Z)-Capsaicin (Zucapsaicin) 是天然辣椒素的合成顺式异构体，用于治疗膝骨关节炎。它是一种可口服的 TRPV1激动剂，可研究神经性疼痛。
T14283	amyloid P-IN-1	Beta Amyloid	Neuroscience
	amyloid P-IN-1 可用于研究血清淀粉样蛋白 P 成分耗尽的疾病，例如阿尔茨海默病、淀粉样变性、骨关节炎和 2 型糖尿病。
T1586	Tenoxicam Ro-12-0068,替诺昔康,Tenoxicamum,Mobiflex,Tilcotil	COX	Immunology/Inflammation; Neuroscience
	Tenoxicam (Tilcotil) 是一种抗炎化合物，具有退热止痛作用。
T15358	Funapide TV 45070,XEN402	Sodium Channel	Membrane transporter/Ion channel
	Funapide (TV 45070) 是一个有效的钠通 Nav1.7 抑制剂，据有潜在的抗炎活性，可用来治疗红斑性肢痛症、肌肉骨骼疼痛、膝关节炎以及疱疹后神经。
T67805	Oxepinac	Others	Others
	oxepinac 是一种治疗疼痛性骨关节炎的有效且耐受性良好的化合物。oxepinac 在动物实验中对小鼠和家兔胎儿无致畸作用。
T27312	Fentiazac Donorest,Flogene,BR-700	Others	Others
	Fentiazac（BR-700）是一种口服活性的非甾体烷酸衍生物，具有显著的镇痛、抗炎和解热活性。Fentiazac 可用于研究类风湿关节炎、骨关节炎、牙周炎和肌腱炎等炎症性疾病。
T35859	Aldumastat GLPG1972,S201086,G504572	Others	Others
	Aldumastat（GLPG1972）是一种具有高效性、特异性和口服活性的 ADAMTS-5抑制剂。Aldumastat 可用于研究膝骨关节炎。
T6568	Licofelone 利克飞龙,ML-3000	Apoptosis; Lipoxygenase; COX	Apoptosis; Immunology/Inflammation; Metabolism; Neuroscience
	Licofelone (ML-3000) 是一种 COX/LOX 双重抑制剂，IC50分别为 0.21和0.18 μM，有潜力研究骨关节炎，具有抗炎和抗增殖作用。它可诱导细胞凋亡，减少促炎性白三烯和前列腺素的产生。
T77092	Nadecnemab REGN-5069	Others	Others
	Nadecnemab 是一种靶向胶质细胞源性神经营养因子家族受体 GFRA3 的 IgG4κ 抗体。Nadecnemab 可用于膝骨关节炎和神经系统疾病。
T29663	ADL-5747 ADL-5747 (free base),ADL5747,ADL-5747 free base	Opioid Receptor	Endocrinology/Hormones; GPCR/G Protein; Neuroscience
	ADL-5747 (ADL-5747 (free base)) (free base)是一种δ opioid 受体激动剂，可用于治疗神经系统疾病、皮肤和肌肉骨骼疾病，可用于研究疱疹后神经痛、膝关节炎和疼痛。
T14978	CL-82198	MMP	Proteases/Proteasome
	CL-82198 是 MMP-13选择性抑制剂。它能够与 MMP-13 的整个 S1' 口袋结合，这是其对 MMP-13 选择性和对其他 MMP 缺乏抑制活性的基础。它可用于研究骨关节炎。
T0219	Valdecoxib 伐地考昔,代他考昔,SC 65872	COX	Immunology/Inflammation; Neuroscience
	Valdecoxib (SC 65872) 是可口服的高选择性 COX-2抑制剂，对 COX-2 和 COX-1 的 IC50值分别为 5 nM 和 140 μM，可用于治疗骨关节炎、类风湿性关节炎以及痛经和经期症状。
T78169	Enpp-1-IN-16	PDE	Metabolism
	Enpp-1-IN-16 是一种靶向 ENPP1 的抑制剂，具有潜在的抗癌症活性。Enpp-1-IN-16 可用于研究胰岛素抵抗与II型糖尿病和软骨钙化病和骨关节炎类由 ENPP1介导的各类疾病。
T7724	Tepoxalin RWJ-20485,RWJ20485,ORF20485,替泊沙林,ORF-20485,RWJ 20485,ORF 20485	Lipoxygenase; COX	Immunology/Inflammation; Metabolism; Neuroscience
	Tepoxalin (RWJ 20485) 是有效的5-脂氧合酶和环氧合酶抑制剂，表现出强大的抗炎活性和较小的胃肠道刺激性。
T1641	Strontium ranelate Distrontium renelate,S12911,雷尼酸锶	Calcium Channel; CaSR	GPCR/G Protein; Membrane transporter/Ion channel; Metabolism
	Strontium ranelate (S12911) 是抗骨质疏松的药物，能够抑制骨吸收，促进骨形成，进而促使正骨平衡。它还能够激活非骨骼细胞中的钙敏感受体 (CaSR)，进而促进肌醇 1，4，5-三磷酸的生成及丝裂原活化的蛋白激酶信号转导。
T8785	HALOFUGINONE LACTATE	DNA/RNA Synthesis; TGF-beta/Smad	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Stem Cells
	HALOFUGINONE LACTATE 是 febrifugine 的卤化衍生物，它是一种天然的含有喹唑啉酮的化合物，存在于中草药 D. febrifuga 中。Halofuginone 以 ATP 依赖性方式抑制脯氨酰-tRNA 合成酶，Ki 为 18.3 nM。 Halofuginone 是 I 型胶原合成的特异性抑制剂，通过抑制 TGF-β 活性来减轻骨关节炎 (OA)
T7072	Pitavastatin	Others	Others
	Pitavastatin (NK-104) 是有效的羟甲基戊二酰-CoA(HMG-CoA)还原酶抑制剂。Pitavastatin 抑制乙酸合成胆固醇，在 HepG2 细胞中的IC50为 5.8 nM。Pitavastatin 是一种高效的肝细胞低密度脂蛋白胆固醇 (LDL-C) 受体诱导剂。Pitavastatin 具有抗动脉粥样硬化、抗哮喘、抗骨关节炎、抗肿瘤、神经保护、肝保护和肾保护等作用。
T0466	Celecoxib 塞来西布,塞来昔布,SC 58635	COX	Immunology/Inflammation; Neuroscience
	Celecoxib (SC 58635) 是一种非甾体抗炎剂，是一种 COX-2 抑制剂 (IC50=40 nM)，具有选择性。Celecoxib 具有抗炎和止痛活性，可以用于治疗骨关节炎、类风湿性关节炎、急性疼痛等。
T27233	Enflicoxib E 6087,E6087,E-6087	Others	Others
	E-6087 is a cyclooxygenase 2 (COX-2) inhibitor potentially for the treatment of osteoarthritis and pain.
T68444	Dircin	Others	Others
	Dircin is an anti-inflammatory agent, prescribed for osteoarthritis and chronic inflammatory arthritis. It works by inhibiting interleukin-1.
T17027	Tedalinab GRC-10693	Cannabinoid Receptor	GPCR/G Protein
	Tedalinab is an effective and selective cannabinoid receptor 2 agonist. Tedalinab has the potential for neuropathic pain and osteoarthritis treatment. Tedalinab has >4700-fold functional selectivity for CB2 over CB1.
T38595	EP4 receptor antagonist 3 EP4 receptor antagonist 3	Others	Others
	EP4 receptor antagonist 3 is a highly potent and specific inhibitor of the EP4 receptor. It is intended for research purposes in studying EP4 receptor-mediated diseases such as acute and chronic pain, osteoarthritis, rheumatoid arthritis, and cancer.
T30939	Cindunistat HCl maleate PHA 728669F,SD 6010,PHA-728669F,SD6010 PF-00572986,SD-6010,PHA728669F	Others	Others
	Cindunistat( PHA-728669F, PF-00572986, PHA-84250, SD-6010, and SC-084250) is a potent and oral selective iNOS inhibitor which is expected to be used in patients with symptomatic osteoarthritis of the knee.
T28032	MF266-1 MF 266-1,MF-266-1	Others	Others
	MF266-1, a selective E prostanoid receptor 4 antagonist, relieves joint inflammation and pain in rodent models of osteoarthritis and rheumatoid.
T29084	V116517 V-116517,V 116517	Others	Others
	V-116517, a TRPV1 antagonist, is used potentially for the treatment of severe pain due to osteoarthritis and chronic pain due postherpetic neuralgia (PHN).
T39000	Zaloglanstat GRC-27864,ISC-27864	Others	Others
	Zaloglanstat (ISC-27864) is a potent inhibitor of microsomal prostaglandin E synthase-1 (mPGES-1). It is utilized in the research of various conditions, including asthma, osteoarthritis, rheumatoid arthritis, acute or chronic pain, and neurodegenerative diseases.
T16291	NF157	COX	Immunology/Inflammation; Neuroscience
	NF157 significantly decreases the expression of metalloproteinase (MMP)-3, MMP-13, which can be used in the treatment of osteoarthritis (OA). NF157 is a highly selective nanomolar P2Y11 antagonist (pKi: 7.35). The IC50s are 463 nM, 1811 µM, 170 µM for P2Y
T16504	PF-4693627	Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation
	PF-4693627 is an effective and selective microsomal prostaglandin E synthase-1 inhibitor (IC50=3 nM). It is used for the treatment of inflammation caused by osteoarthritis (OA) and rheumatoid arthritis (RA).
T14352	Autotaxin-IN-1	PDE	Metabolism
	Autotaxin-IN-1 is a potent autotaxin inhibitor, which has favorable potency (IC50=2.2 nM), PK properties, and a robust PK/PD relationship and it is used in treatment of osteoarthritis pain[1].
T39047	DDR2-IN-1 DDR2-IN-1	Others	Others
	DDR2-IN-1 (Compound 129) is recognized as a highly effective DDR2 inhibitor, displaying an IC50 value of 26 nM. It is a suitable choice for conducting osteoarthritis research.
T72868	ADAMTS-5-IN-2	Others	Others
	ADAMTS-5-IN-2 是一种有效的ADAMTS-5抑制剂，IC50值为 0.71 µM。ADAMTS-5-IN-2 具有改善骨关节炎的研究潜力。
T16570	Pralnacasan VX-740,HMR 3480	Others	Others
	Pralnacasan inhibits proinflammatory cytokines IL-18, IL-1β , and IFN-γ. Pralnacasan is an effective, non-peptide, and orally active interleukin-1β converting enzyme inhibitor (Ki: 1.4 nM). Pralnacasan has the potential for osteoarthritis and rheumatoid a
T26563	Adavivint HCl (1467093-03-3 free base) SM-04690,Adavivint HCl,Adavivint,SM04690,SM 04690	Others	Others
	Adavivint, also known as SM04690, is a small-molecule inhibitor of the Wnt pathway which is being investigated as a potential disease modifying agent for the treatment of osteoarthritis of the knee
T76077	MMP-13 Substrate
	MMP-13Substrate 是MMP-13的底物。MMP-13Substrate 可用于骨关节炎 (OA) 的研究。

化合物

Cat.No: T2553

Target: COX

Cat.No: T16124

Target: MMP

Cat.No: T1748

Synonym: KGN

Target: TGF-beta/Smad

Cat.No: T0291

Synonym: 氟比洛芬,dl-Flurbiprofen

Target: Apoptosis, COX, MRP

Cat.No: T1421

Synonym: 醋氯芬酸,Preservex,Airtal

Target: COX

Cat.No: T9977

Target: SGK

Cat.No: T9711

Target: Others

Cat.No: T6574

Synonym: Prexige,罗美昔布,COX-189

Target: COX

Tiaprofenic acid

Cat.No: T4561

Synonym: Tiaprofensaeure,噻洛芬酸,Acido tiaprofenico,Surgam

Target: Others, COX

Cat.No: T4552

Synonym: Diteftin,呋喃硫胺,Judolor,Alinamin F

Target: Others

Cat.No: T1780

Synonym: SC 69124,帕瑞昔布,Vorth-P,Valus-P

Target: COX

Cat.No: T0859

Synonym: 芬布芬,CL-82204,Lederfen

Target: ATPase, Caspase, COX

Cat.No: T5099

Synonym: RO 4926219,AF219,MK-7264

Target: P2X Receptor

Cat.No: T11340

Target: Prostaglandin Receptor

Cat.No: T28394

Synonym: PG-530742,PGE-7113313,PGE 7113313,PG 530742

Target: MMP

Wnt pathway inhibitor 3

Cat.No: T77502

Target: Wnt/beta-catenin, Adenylyl cyclase

Cat.No: T1109

Synonym: Zucapsaicin,Civamide,cis-Capsaicin,珠卡赛辛,(Z)-辣椒素

Target: TRP/TRPV Channel, HSV

Cat.No: T14283

Target: Beta Amyloid

Cat.No: T1586

Synonym: Ro-12-0068,替诺昔康,Tenoxicamum,Mobiflex,Tilcotil

Target: COX

Cat.No: T15358

Synonym: TV 45070,XEN402

Target: Sodium Channel

Cat.No: T67805

Target: Others

Cat.No: T27312

Synonym: Donorest,Flogene,BR-700

Target: Others

Cat.No: T35859

Synonym: GLPG1972,S201086,G504572

Target: Others

Cat.No: T6568

Synonym: 利克飞龙,ML-3000

Target: Apoptosis, Lipoxygenase, COX

Cat.No: T77092

Synonym: REGN-5069

Target: Others

Cat.No: T29663

Synonym: ADL-5747 (free base),ADL5747,ADL-5747 free base

Target: Opioid Receptor

Cat.No: T14978

Target: MMP

Cat.No: T0219

Synonym: 伐地考昔,代他考昔,SC 65872

Target: COX

Cat.No: T78169

Target: PDE

Cat.No: T7724

Synonym: RWJ-20485,RWJ20485,ORF20485,替泊沙林,ORF-20485,RWJ 20485,ORF 20485

Target: Lipoxygenase, COX

Strontium ranelate

Cat.No: T1641

Synonym: Distrontium renelate,S12911,雷尼酸锶

Target: Calcium Channel, CaSR

HALOFUGINONE LACTATE

Cat.No: T8785

Target: DNA/RNA Synthesis, TGF-beta/Smad

Cat.No: T7072

Target: Others

Cat.No: T0466

Synonym: 塞来西布,塞来昔布,SC 58635

Target: COX

Cat.No: T27233

Synonym: E 6087,E6087,E-6087

Target: Others

Cat.No: T68444

Target: Others

Cat.No: T17027

Synonym: GRC-10693

Target: Cannabinoid Receptor

EP4 receptor antagonist 3

Cat.No: T38595

Synonym: EP4 receptor antagonist 3

Target: Others

Cindunistat HCl maleate

Cat.No: T30939

Synonym: PHA 728669F,SD 6010,PHA-728669F,SD6010 PF-00572986,SD-6010,PHA728669F

Target: Others

Cat.No: T28032

Synonym: MF 266-1,MF-266-1

Target: Others

Cat.No: T29084

Synonym: V-116517,V 116517

Target: Others

Cat.No: T39000

Synonym: GRC-27864,ISC-27864

Target: Others

Cat.No: T16291

Target: COX

Cat.No: T16504

Target: Prostaglandin Receptor

Cat.No: T14352

Target: PDE

Cat.No: T39047

Synonym: DDR2-IN-1

Target: Others

Cat.No: T72868

Target: Others

Cat.No: T16570

Synonym: VX-740,HMR 3480

Target: Others

Adavivint HCl (1467093-03-3 free base)

Cat.No: T26563

Synonym: SM-04690,Adavivint HCl,Adavivint,SM04690,SM 04690

Target: Others

MMP-13 Substrate

Cat.No: T76077

Cat. No.	Product Name	Target	Signaling Pathways
T5689	20-DEOXYINGENOL	Others; Autophagy	Autophagy; Others
	20-Deoxyingenol 是从甘遂的根中分离出的一种二萜类天然产物。它可通过促进体外转录因子 EB 的核易位来促进自噬和溶酶体生物发生，可研究骨关节炎。
T3803	Specnuezhenide 特女贞苷,Nuzhenide,Nuezhenide	Others; NF-κB; Wnt/beta-catenin	Cytoskeletal Signaling; NF-κB; Others; Stem Cells
	Specnuezhenide (Nuezhenide) 是分离自女贞子的果实中。它可抑制 NF-κB 和 wnt/β-catenin 信号传导，进而抑制 IL-1β 诱导的软骨细胞炎症。它可在骨关节炎 (OA) 大鼠模型中发挥抗炎作用。
T5029	Oxaceprol 奥沙西罗,N-Acetyl-L-hydroxyproline,N-乙酰-L-4-羟基脯氨酸	Others	Others
	Oxaceprol (N-Acetyl-L-hydroxyproline) 是一种可口服的、具有显著抗炎作用的 L-脯氨酸衍生物，常用于研究骨关节炎和类风湿性关节炎。
T6S0117	Avicularin Fenicularin,扁蓄苷	ERK	MAPK
	Avicularin (Fenicularin) 具有抗过敏、抗炎、保肝、抗氧化、抗肿瘤等活性。它能通过调节 NF-κB(p65)、COX-2 和 PPAR-γ 的活性来改善人类肝细胞癌。在 LPS 刺激的 RAW 264.7 巨噬细胞中，它通过抑制 ERK 信号通路产生抗炎活性。
T6856	Halofuginone 卤夫酮,常山酮,Tempostatin,empostatin,RU-19110	Calcium Channel; DNA/RNA Synthesis; Sodium Channel; Parasite; TGF-beta/Smad	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Membrane transporter/Ion channel; Metabolism; Microbiology/Virology; Stem Cells
	Halofuginone (RU-19110) 是Febrifugine 的衍生物，是一种竞争性脯氨酰-tRNA 合成酶抑制剂。它也是肺血管扩张剂，可激活Kv 通道并阻断电压门控、受体操作和存储操作的钙离子通道。它具有抗炎、抗癌、抗疟疾和抗纤维化作用。
T3524	Halofuginone hydrobromide 卤夫酮溴氢酸盐,Tempostatin,RU-19110 (hydrobromide),Stenorol,常山酮溴酸盐	Others; Calcium Channel; DNA/RNA Synthesis; Sodium Channel; Parasite; TGF-beta/Smad	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Membrane transporter/Ion channel; Metabolism; Microbiology/Virology; Others; Stem Cells
	Halofuginone hydrobromid 是Febrifugine 的衍生物，是竞争性脯氨酰-tRNA 合成酶抑制剂。它是 I 型胶原合成的特异性抑制剂，并通过抑制TGF-β活性可减轻骨关节炎。它具有抗疟疾、抗炎、抗癌、抗纤维化作用。
T7475	S-Adenosyl-L-methionine AdoMet,Ademetionine,SAMe,S-Adenosyl methionine,S-腺苷-L-蛋氨酸	Others; Endogenous Metabolite	Metabolism; Others
	S-Adenosyl-L-methionine (Ademetionine) 是一种具有有效的抗抑郁和减轻疼痛作用的膳食补充剂，是通过蛋氨酸腺苷转移酶的作用由蛋氨酸和 ATP 内源性生产的，是一种重要的口服具有活力的甲基供体，能够用于肝病和骨关节炎的研究。
T2941	Glucosamine hydrochloride Chitosamine hydrochloride,盐酸氨基葡萄糖,2-Amino-2-deoxy-glucose HCl,Chitosamine HCl,D-(+)-Glucosamine hydrochloride	Reactive Oxygen Species; HIF/HIF Prolyl-Hydroxylase; Endogenous Metabolite; Autophagy	Autophagy; Chromatin/Epigenetic; Immunology/Inflammation; Metabolism; NF-κB
	Glucosamine hydrochloride (Chitosamine hydrochloride) 是软骨基质和滑液中糖胺聚糖的天然成分，常用作骨关节炎的治疗方法。它也是一种氨基糖，是糖基化蛋白和脂质生化合成的突出前体，用作膳食补充剂。
T1273	Diacerein 双醋瑞因,Diacerhein,Fisiodar,Diacetylrhein	IL Receptor; Interleukin	Immunology/Inflammation
	Diacerein (Fisiodar) 是一种慢效具有白介素-1β 抑制效果的蒽醌类化合物。
T4S2157	Campesterol 菜油甾醇,(24R)-5-Ergosten-3β-ol	Endogenous Metabolite	Metabolism
	Campesterol ((24R)-5-Ergosten-3β-ol) 是一种植物甾醇，具有降胆固醇和抗癌的活性。
T4447	S-(5'-Adenosyl)-L-methionine tosylate S-腺苷蛋氨酸对甲苯磺酸盐,SAMe,S-(5'-Adenosyl)-L-methionine p-toluenesulfonate salt	Others	Others
	S-(5'-Adenosyl)-L-methionine tosylate (SAMe) 是一种普遍存在的甲基供体，参与多种生物反应，包括由 DNA 和蛋白质甲基转移酶介导的反应。它可改善抑郁、与骨关节炎和纤维肌痛相关的疼痛以及肝毒性。
T3388	Calycosin-7-O-β-D-glucoside 毛蕊异黄酮苷,calycosin-7-O-beta-D-glucopyranoside,Calycosin-7-O-beta-D-glucoside	MMP; Reactive Oxygen Species	Immunology/Inflammation; Metabolism; NF-κB; Proteases/Proteasome
	Calycosin-7-O-β-D-glucoside (calycosin-7-O-beta-D-glucopyranoside) 是一种异黄酮，从黄芪中分离得到。它具有多种生物活性，包括心脏保护、神经保护、抗炎和抗氧化作用。
T30048	Anemonin (6CI) Pulsatilla camphor,Anemonin,Anemone camphor	Others	Others
	Anemonin is a furanone dimer found in the Buttercup (Ranunculaceae) family. Anemonin has been shown to regulate tyrosinase-related proteins and mRNA in human melanocytes and may be useful in attenuting osteoarthritis progression.
T4116	S-Adenosyl-DL-Methionine Ademetionine,S-腺苷蛋氨酸,S-ADENOSYL-L-METHIONINE	Others	Others
	S-Adenosyl-DL-Methionine (Ademetionine) 是一种 Ademetionine 的衍生物。其中Ademetionine 是蛋氨酸的中间代谢产物。
T78468	Yohimbic acid hydrate	Others	Others
	Yohimbic acid hydrate，一种Yohimbine的两性脱甲基衍生物，具有血管舒张效果，且在骨关节炎（OA）研究中展现出潜在应用价值。

天然产物

20-DEOXYINGENOL

Cat.No: T5689

Target: Others, Autophagy

Cat.No: T3803

Synonym: 特女贞苷,Nuzhenide,Nuezhenide

Target: Others, NF-κB, Wnt/beta-catenin

Cat.No: T5029

Synonym: 奥沙西罗,N-Acetyl-L-hydroxyproline,N-乙酰-L-4-羟基脯氨酸

Target: Others

Cat.No: T6S0117

Synonym: Fenicularin,扁蓄苷

Target: ERK

Cat.No: T6856

Synonym: 卤夫酮,常山酮,Tempostatin,empostatin,RU-19110

Target: Calcium Channel, DNA/RNA Synthesis, Sodium Channel, Parasite, TGF-beta/Smad

Halofuginone hydrobromide

Cat.No: T3524

Synonym: 卤夫酮溴氢酸盐,Tempostatin,RU-19110 (hydrobromide),Stenorol,常山酮溴酸盐

Target: Others, Calcium Channel, DNA/RNA Synthesis, Sodium Channel, Parasite, TGF-beta/Smad

S-Adenosyl-L-methionine

Cat.No: T7475

Synonym: AdoMet,Ademetionine,SAMe,S-Adenosyl methionine,S-腺苷-L-蛋氨酸

Target: Others, Endogenous Metabolite

Glucosamine hydrochloride

Cat.No: T2941

Synonym: Chitosamine hydrochloride,盐酸氨基葡萄糖,2-Amino-2-deoxy-glucose HCl,Chitosamine HCl,D-(+)-Glucosamine hydrochloride

Target: Reactive Oxygen Species, HIF/HIF Prolyl-Hydroxylase, Endogenous Metabolite, Autophagy

Cat.No: T1273

Synonym: 双醋瑞因,Diacerhein,Fisiodar,Diacetylrhein

Target: IL Receptor, Interleukin

Cat.No: T4S2157

Synonym: 菜油甾醇,(24R)-5-Ergosten-3β-ol

Target: Endogenous Metabolite

S-(5'-Adenosyl)-L-methionine tosylate

Cat.No: T4447

Synonym: S-腺苷蛋氨酸对甲苯磺酸盐,SAMe,S-(5'-Adenosyl)-L-methionine p-toluenesulfonate salt

Target: Others

Calycosin-7-O-β-D-glucoside

Cat.No: T3388

Synonym: 毛蕊异黄酮苷,calycosin-7-O-beta-D-glucopyranoside,Calycosin-7-O-beta-D-glucoside

Target: MMP, Reactive Oxygen Species

Cat.No: T30048

Synonym: Pulsatilla camphor,Anemonin,Anemone camphor

Target: Others

S-Adenosyl-DL-Methionine

Cat.No: T4116

Synonym: Ademetionine,S-腺苷蛋氨酸,S-ADENOSYL-L-METHIONINE

Target: Others

Yohimbic acid hydrate

Cat.No: T78468

Target: Others

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPJ-00249	TGF beta 1 Protein, Human, Recombinant (Avi), Biotinylated TGF-Beta-1,TGFB1,Transforming Growth Factor β-1,Latency-Asso...	Human	HEK293 Cells
	Transforming Growth Factor β-1 (TGFβ-1) is a secreted protein which belongs to the TGF-β family. TGFβ-1 is abundantly expressed in bone, articular cartilage and chondrocytes and is increased in osteoarthritis (OA). TGFβ-1 performs many cellular functions, including the control of cell growth, cell proliferation, cell differentiation and apoptosis. The precursor is cleaved into a latency-associated peptide (LAP) and a mature TGFβ-1 peptide. TGFβ-1 may also form heterodimers with other TGFβ family...
TMPK-00019	B2M/beta 2-Microglobulin Protein, Human, Recombinant (hFc) Beta-2-microglobulin,B2M/β 2-Microglobulin,β-2-microglobulin...	Human	HEK293 Cells
	To assess whether beta-2 microglobulin (B2M) has effects on articular chondrocytes that would implicate B2M involvement in osteoarthritis (OA) pathogenesis.The average B2M level in OA synovial fluid is significantly higher than that found in normal synovial fluid. B2M is highly expressed in OA cartilage and synovial fluid compared to normal, and suggest that B2M may have effects on chondrocyte function that could contribute to OA pathogenesis.
TMPY-03384	CALM2 Protein, Human, Recombinant (His) caM,calmodulin 2 (phosphorylase kinase, delta),PHKD,calmodul...	Human	E. coli
	Calmodulin 2, also known as CALM2, is a calmodulin. Calmodulin 2 mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+). It is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis. Calmodulin 2 gene may be a genetic determinant of hip osteoarthritis (OA). OA is a degenerative disease characterized by gradual loss of articular cartilage and is a leading cause of disability in elderly populations. CALM2 was most...
TMPY-03847	FRZB Protein, Human, Recombinant (His) frizzled-related protein,FRITZ,OS1,SFRP3,FRZB-PEN,FRP-3,FRE,...	Human	HEK293 Cells
	FRZB also known as sFRP-3, is a secreted protein containing a domain similar to the putative Wnt-binding region of the frizzled family of transmembrane receptors. FRZB is widely expressed in adult mammalian tissues. In the Xenopus gastrula, FRZB is regulated as a typical Spemann organizer component. FRZB also functions as a competitor for the cell-surface G-protein receptor Frizzled. It is espically important in embryonic development. Defects in FRZB gene can cause female-specific osteoarthritis...
TMPY-01860	Collagen II/COL2A1 Protein, Human, Recombinant (aa 1242-1487, His) SEDC,collagen, type II, alpha 1,COL11A3,AOM,STL1,collagen, t...	Human	HEK293 Cells
	COL2A1 is the alpha-1 chain of type II collagen which is a fibrillar collagen found in cartilage and the vitreous humor of the eye. Mutations in this protein are associated with achondrogenesis, chondrodysplasia, early onset familial osteoarthritis, SED congenita, Langer-Saldino achondrogenesis, Kniest dysplasia, Stickler syndrome type I, and spondyloepimetaphyseal dysplasia Strudwick type. In addition, defects in processing chondrocalcin, a calcium binding protein that is the C-propeptide of th...
TMPJ-00966	GDF-5 Protein, Human, Recombinant Lipopolysaccharide-associated protein 4,Cartilage-derived mo...	Human	E. coli
	Growth Differentiation Factor 5(GDF-5, BMP-14) is a member of the BMP family of TGFβ superfamily proteins. Human GDF-5, -6, and -7 are a defined subgroup of the BMP family. GDF-5 is synthesized as a homodimeric precursor protein consisting of a 354 amino acid (aa) Nterminal proregion and a 120 aa C-terminal mature peptide. Mature human GDF-5 shares 99% aa sequence identity with both mature mouse and rat GDF-5. GDF-5 signaling is mediated by formation of a heterodimeric complex consisting of a ty...

重组蛋白

TGF beta 1 Protein, Human, Recombinant (Avi), Biotinylated

Cat.No: TMPJ-00249

Species: Human

Expression System: HEK293 Cells

B2M/beta 2-Microglobulin Protein, Human, Recombinant (hFc)

Cat.No: TMPK-00019

Species: Human

Expression System: HEK293 Cells

CALM2 Protein, Human, Recombinant (His)

Cat.No: TMPY-03384

Species: Human

Expression System: E. coli

FRZB Protein, Human, Recombinant (His)

Cat.No: TMPY-03847

Species: Human

Expression System: HEK293 Cells

Collagen II/COL2A1 Protein, Human, Recombinant (aa 1242-1487, His)

Cat.No: TMPY-01860

Species: Human

Expression System: HEK293 Cells

GDF-5 Protein, Human, Recombinant

Cat.No: TMPJ-00966

Species: Human

Expression System: E. coli

Cat. No.	Product Name	Target	Signaling Pathways
TMIJ-0119	Pitavastatin-d4 Sodium Salt
	Pitavastatin-d4 Sodium Salt 是 Pitavastatin Sodium Salt 的氘代化合物。Pitavastatin Sodium Salt 的 CAS 号为 574705-92-3。
TMIJ-0337	(24Rac)-Campesterol-d7
	(24Rac)-Campesterol-d7 是 (24Rac)-Campesterol 的氘代化合物。(24Rac)-Campesterol 的 CAS 号为 474-62-4。Campesterol是一种植物甾醇，具有降胆固醇和抗癌的活性。

同位素标记化合物

Pitavastatin-d4 Sodium Salt

Cat.No: TMIJ-0119

(24Rac)-Campesterol-d7

Cat.No: TMIJ-0337

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