PF-4693627

产品编号 T16504Cas号 1312815-93-2

别名

PF-4693627 is an effective and selective microsomal prostaglandin E synthase-1 inhibitor (IC50=3 nM). It is used for the treatment of inflammation caused by osteoarthritis (OA) and rheumatoid arthritis (RA).

PF-4693627

产品编号 T16504Cas号 1312815-93-2

规格	价格	库存
500 μg	¥ 647	35日内发货
1 mg	¥ 1,190	35日内发货
5 mg	¥ 5,580	35日内发货
10 mg	¥ 9,870	35日内发货

大包装 & 定制

加入购物车

实验操作小课堂

联系我们获取更多批次信息

资源下载

产品操作手册

TargetMol 的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

产品介绍

生物活性

产品描述	PF-4693627 is an effective and selective microsomal prostaglandin E synthase-1 inhibitor (IC50=3 nM). It is used for the treatment of inflammation caused by osteoarthritis (OA) and rheumatoid arthritis (RA).
靶点活性	mPGES-1:3 nM
体外活性	PF-4693627 displays high activity in lipopolysaccharide (LPS) stimulated human whole blood (HWB) cell assay (IC50=109 nM). PF-4693627 also inhibits mPGES-1 (IC50s: 180 and 6 nM in HWB-1483 and human fetal fibroblast, respectively).
体内活性	PF-4693627 (1.0 mg/kg; i.v.) displays good bioavailability (59%) and modest half-life (t1/2=3.7 h) in Sprague-Dawley rats. PF-4693627 (10 mg/kg; orally) suppresses 63% of PGE2 production relative to vehicle control in the Guinea pig carrageenan stimulated air pouch model[1].