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Search Results for " non-covalent "

Targets Recommended: Virus Protease SARS-CoV

57

抑制剂 & 化合物

1

天然产物

2

化合物库

10

重组蛋白

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Cat. No.	Product Name
L9410	共价抑制剂库		1920 compounds
	1920 种小分子的独特集合，包含已发现的共价抑制剂以及包含某些共价反应基团常见弹头的分子，如氯乙酰基，2-氯丙酰基，丙烯酰基，1-丙-2-炔基，1-丁-2-炔基，酮羰基，二硫键等，可以用于共价抑制剂药物研发；
DO2200	共价抑制剂库CD		12000 compounds
	数量多：超过12000种共价结合化合物，并且数量在持续增加；

化合物库

共价抑制剂库

Cat.No: L9410

Compounds: 1920

共价抑制剂库CD

Cat.No: DO2200

Compounds: 12000

Cat. No.	Product Name	Target	Signaling Pathways
T8371	ML188	Virus Protease; SARS-CoV	Microbiology/Virology
	ML188是一种选择性非共价 SARS-CoV3CLpro 抑制剂，具有抗病毒活性，IC50为 1.5 μM。
T8926	Salcaprozate sodium 8-(2-羟基苯甲酰胺基)辛酸钠,SNAC	Others	Others
	Salcaprozate sodium (SNAC) 是口服吸收促进剂，有作为口服形式的肝素和胰岛素递送剂的潜力。它可提高非共价大分子络合引起的亲脂性，从而增加小肠上皮细胞的被动跨细胞渗透。
T10898	Samuraciclib hydrochloride ICEC0942 hydrochloride,CT7001 hydrochloride	Apoptosis; CDK	Apoptosis; Cell Cycle/Checkpoint
	Samuraciclib hydrochloride (ICEC0942 hydrochloride) 是一种具有选择性，ATP 竞争性和口服活性的CDK7抑制剂，IC50为 41 nM。它以 GI50值为 0.2-0.3 µM 来抑制乳腺癌细胞系的生长，具有抗肿瘤作用。
T11469	GSK-3484862	DNA Methyltransferase	Chromatin/Epigenetic
	GSK-3484862 是有效的 DNA 甲基转移酶 Dnmt1的非共价抑制剂。GSK-3484862 通过诱导 DNA 低甲基化起抗癌作用。GSK-3484862 介导小鼠胚胎干细胞的整体去甲基化。
T9303	MRTX1133	Ras	GPCR/G Protein; MAPK
	MRTX1133 是一种 KRAS G12D 抑制剂 (KD=0.2 pM)，具有强效性、选择性和非共价性。MRTX1133 对 KRAS G12D 突变的肿瘤具有抑制活性，而对 KRAS 野生型肿瘤无抑制活性。
T17389	AMAS	Others; ADC Linker	Antibody-drug Conjugate/ADC Related; Others
	AMAS 是一种不可裂解的异双功能交联剂，具有 NHS 酯和马来酰亚胺基团，可实现含胺和巯基分子的共价结合。
T8431	JCN037	EGFR	Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	JCN037 是能透过血脑屏障的EGFR 共价抑制剂，对 EGFR、p-wtEGFR 和 pEGFRvⅢ 的IC50值分别为 2.49、3.95 和4.48 nM。
T40292	Opnurasib NVP-JDQ443,JDQ-443,Opnurasib	Ras	GPCR/G Protein; MAPK
	Opnurasib (JDQ-443) 是一种可口服且具有选择性和有效性的共价 KRAS G12C 抑制剂，具有抗肿瘤活性，可用于研究晚期非小细胞肺癌。
T8766	GOT1 inhibitor-1 GOT1 inhibitor 2c	Others	Others
	GOT1 inhibitor-1 (GOT1 inhibitor 2c) 是一种新型的、非共价的谷氨酸草酰乙酸转氨酶 1 (GOT1) 抑制剂(IC50:8.2 uM)，是一种戊酸衍生物。它可用于以及胰腺导管腺癌 (PDAC) 。
T11724	JNJ-42226314	Lipase	Metabolism
	JNJ-42226314 是一种具有高选择性的非共价单酰基甘油脂肪酶 (MAGL) 抑制剂，具有抗伤害作用。JNJ-42226314 通过内源性大麻素-2-丙烯酰甘油（2-AG）在神经病理性疼痛和炎症性疼痛模型中显示出疗效。
T36287	Pirtobrutinib	BTK	Angiogenesis; Tyrosine Kinase/Adaptors
	Pirtobrutinib (LOXO-305) is an advanced BTK inhibitor that displays high selectivity and operates through a non-covalent mechanism. This compound effectively inhibits various BTK C481 substitution mutations, leading to tumor regression in BTK-dependent lymphoma tumors in mouse xenograft models. Furthermore, Pirtobrutinib exhibits remarkable selectivity for BTK, with more than a 300-fold difference compared to 370 other kinases tested. Notably, at a concentration of 1 μM, Pirtobrutinib demonstrat...
T9573	GSK3685032	DNA Methyltransferase	Chromatin/Epigenetic
	GSK-3685032 是一种非时间依赖、非共价、选择性的、可逆的DNMT1抑制剂，IC50=0.036 μM。它诱导 DNA 甲基化丧失、转录激活和癌细胞生长抑制。
T5461	GNE-6640	DUB	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Ubiquitination
	GNE 6640 是一种选择性泛素特异性肽酶 7(USP7)的非共价抑制剂，其对全长USP7、USP7 催化结构域、全长USP43 以及 Ub-MDM2 的IC50值分别为 0.75 μM、0.43 μM、20.3 μM 和 0.23 μM。
T40063	CBR-470-1	Nrf2	Immunology/Inflammation
	CBR-470-1 是一种有效的糖酵解磷酸甘油酸激酶1 (PGK1) 抑制剂，通过增加甲基乙二醛的水平来激活 NRF2。 CBR-470-1 是一种非共价的 Nrf2 激活剂，具有神经保护活性，通过激活 Keap1-Nrf2 级联反应来保护 SH-SY5Y 神经元细胞免受 MPP+ 诱导的细胞毒性。
T72062	BI-2865	Ras	GPCR/G Protein; MAPK
	BI-2865 是一种非共价的泛-KRAS 抑制剂。BI-2865 可与 KRAS WT、G12C、G12D、G12V 和 G13D 突变体结合，KD 值分别为 6.9、4.5、32、26、4.3 nM。BI-2865在对表达 KRAS G12C、G12D 或 G12V 突变体的 BaF3 细胞实验的过程中显示出抗增殖活性，平均 IC50值大约为 140 nM。
T38889	Thailanstatin A	Others; ADC Cytotoxin	Antibody-drug Conjugate/ADC Related; Others
	Thailanstatin A 是真核 RNA 剪接抑制剂，IC50为650 nM，通过非共价结合到剪接体的 U2 snRNA 亚复合物的 SF3b 亚单位发挥作用。Thailanstatin A 对多种癌细胞系的抑制显示 nM 级别的 IC50。它与 Trastuzumab 上的赖氨酸结合，可产生“无连接子” ADC。
T10534	BI-4020	EGFR	Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	BI-4020 是一种第四代，口服有效，非共价的 EGFR 酪氨酸激酶抑制剂。BI-4020 表现出对三联突变的 EGFR del19 T790M C797S 突变体 ( BaF3 细胞系，IC50=0.2 nM)，双重突变的 EGFR del19 T790M 以及单突变的 EGFR del19 (IC50=1 nM)的抑制剂活性。BI-4020 保留了抑制 EGFR wt 的活性 (IC50=190 nM)。BI-4020 具有高激酶组选择性和良好的 DMPK 性质。
T11159	EGFR-IN-2	EGFR	Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	EGFR-IN-2 is a non-covalent, mutation-selective and irreversible second-generation EGFR inhibitor.
T69545	Mpro 61	Others	Others
	Mpro 61 is a potent non-covalent inhibitor of SARS-CoV-2 main protease.
T14915	CDK12-IN-E9	CDK	Cell Cycle/Checkpoint
	CDK12-IN-E9 is a potent and selective covalent CDK12 inhibitor and non-covalent CDK9 inhibitor while avoiding ABC transporter-mediated efflux. It has a weak binding ability to CDK7/CyclinH complex (IC50> 1 μM).
T12621	(R)-FT671	Others	Others
	(R)-FT671 is the R-isomer of FT671. FT671 is a potent, non-covalent and selective inhibitor of USP7 (IC50 of 52 nM)
T12621L	FT671	DUB	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Ubiquitination
	FT671 is a non-covalent and selective inhibitor of USP7 (IC50: 52 nM) It also binds to the USP7 catalytic domain (Kd: 65 nM).
T63800	ZM223 hydrochloride	Others	Others
	ZM223 hydrochloride 是有效的、非共价的、口服具有活力的 NEDD8 活化酶 (NAE) 抑制剂。
T19568	Sulfo-SMPB sodium	Others; ADC Linker	Antibody-drug Conjugate/ADC Related; Others
	Sulfo-SMPB sodium is a non-cleavable heterobifunctional chemical cross-linking reagent that combines N-hydroxysuccinimide ester and maleimide groups. This compound enables the covalent conjugation of molecules possessing amine and sulfhydryl functionalities.
T10422	Avibactam free acid NXL-104 free acid	Antibacterial	Microbiology/Virology
	Avibactam (NXL-104) free acid is a covalent and reversible inhibitor of non-β-lactam β-lactamase (IC50s: 8 nM and 5 nM for β-lactamase TEM-1 and CTX-M-15).
T35844	(R)-Pirtobrutinib	Others	Others
	(R)-Pirtobrutinib ((R)-LOXO-305) is a less active enantiomer of Pirtobrutinib, and Pirtobrutinib is a highly selective and non-covalent next generation BTK inhibitor. Pirtobrutinib (LOXO-305) effectively inhibits diverse BTK C481 substitution mutations[1].
T13412L	ZM223 hydrochloride (2031177-48-5 free base) ZM223 hydrochloride	Serine Protease	Proteases/Proteasome
	ZM223 hydrochloride is an orally active, potent non-covalent inhibitor of NEDD8 activating enzyme (NAE), and with excellent anticancer activity.
T73510	ZG1077	Others	Others
	ZG1077 是一种共价的KRAS G12C 抑制剂。ZG1077 可用于非小细胞肺癌 (NSCLC) 的研究。
T39648	(R)-GSK-3685032	Others	Others
	(R)-GSK-3685032 is the R-enantiomer of GSK-3685032. GSK-3685032 is a first-in-class, non-time-dependent, non-covalent, reversible, selective DNMT1 inhibitor with an IC 50 of 0.036 μM. GSK-3685032 induces robust loss of DNA methylation, transcriptional activation and inhibition of cancer cell growth.
T40358	Ensitrelvir fumarate S-217622 fumarate	Others	Others
	Ensitrelvir (S-217622) fumarate is a novel orally active inhibitor, targeting the SARS-CoV-2 3CL protease (IC50 = 13 nM). It demonstrates non-covalent and non-peptidic characteristics. This compound represents a pioneering advancement in the development of effective antiviral agents against the SARS-CoV-2 virus.
T26827	Bisnorcymserine N1 N8 Bisnorcymserine,N1N8Bisnorcymserine,N1-N8-Bisnorcymserine	Others	Others
	Bisnorcymserine is a reversible inhibitor of butyrylcholinesterase. The leaving group, bisnoreseroline, interacts in a non-covalent way with Ser(200) and His(440), disrupting the existing interactions within the catalytic triad, and it stacks with Trp(84)
T39859	ARN19689	Others	Others
	ARN19689 is an effective inhibitor of human NAAA, demonstrating high potency in the low nanomolar range (IC 50 = 0.042 μM). The compound acts through a non-covalent mechanism, highlighting its ability to interact with the enzyme for inhibition.
T75255L	SB-435495 hydrochloride	Others	Others
	SB-435495 hydrochloride，一种有效的、选择性的、可逆性非共价口服Lp-PLA2抑制剂，IC50值为0.06 nM。
T82137	IA1-8H2	Others	Others
	IA1-8H2是一种PHPT1的非共价、非竞争性抑制剂，具有3.4 μM的IC50。该化合物在肺癌、肝癌、肾癌等多种癌症的研究中有应用潜力。
T75255L1	SB-435495 ditartrate	Others	Others
	SB-435495 ditartrate，一种口服有效的Lp-PLA2抑制剂，特点为高效、选择性、可逆且非共价，IC50值为0.06 nM。
T39430	XMU-MP-3	Others	Others
	XMU-MP-3 is a robust, non-covalent inhibitor of BTK, exhibiting exceptional potency with IC50 values of 10.7 nM and 17.0 nM for BTK WT and BTK C481S mutation, respectively, in the presence of 10 μM ATP. Moreover, XMU-MP-3 elicits apoptosis.
T79344	CDD-1819	SARS-CoV	Microbiology/Virology
	CDD-1819为非共价、非肽类SARS-CoV-2 Mpro有效抑制剂，其Ki值为5 nM。该化合物同样抑制ΔP168、A173V及ΔP168/A173V Mpro突变体。
T37085	Luxeptinib	Others	Others
	Luxeptinib (CG-806) is a novel pan-FLT3/pan-BTK inhibitor that is administered orally. It exhibits potent and reversible inhibition of these enzymes, acting through a non-covalent mechanism. Luxeptinib effectively induces cell cycle arrest, apoptosis, or autophagy in acute myeloid leukemia cells [1][2][3][4].
T79345	CDD-1733	SARS-CoV	Microbiology/Virology
	CDD-1733是SARS-CoV-2 Mpro的非共价非肽抑制剂，具有12 nM的Ki值。该化合物也能够抑制ΔP168、A173V及ΔP168/A173V Mpro突变体。
T79346	CDD-1845	SARS-CoV	Microbiology/Virology
	CDD-1845，一种非共价非肽类SARS-CoV-2 Mpro抑制剂，具有3 nM的Ki值。该化合物同样能抑制ΔP168、A173V及ΔP168/A173V的Mpro突变体。
T75109	HECT E3-IN-1	Others	Others
	HECT E3-IN-1 (compound 3) 为HECT E3 连接酶的抑制剂，其作用机制为破坏Nedd4-1 的非共价Ub结合位点与Ub的结合。
T81849	MAT-POS-e194df51-1	SARS-CoV	Microbiology/Virology
	MAT-POS-e194df51-1 是一种非共价、非肽类、口服活性的SARS-CoV-2主蛋白酶 (Mpro) 抑制剂，IC50 值达 37nM。该化合物展现细胞毒性，其在 A549-ACE2-TMPRSS2 和 HeLa-ACE2 细胞线上的 EC50 值分别为 64 nM 和 126 nM。
T74849	EBL-3183	Others	Others
	EBL-3183为一种吲哚-2-羧酸盐，作为有效的金属-β-内酰胺酶(MBL)抑制剂。它通过可逆结合、非共价及竞争性作用抑制NDM-1，其pIC50值为7.7。
T9671	X77	Others	Others
	X77 是 SARS-CoV-2 主要蛋白酶 (SARS-CoV-2 Mpro) 的有效非共价键抑制剂。X77 与 SARS-CoV-2 Mpro 结合，Kd 值为 0.057 μM。
T72762	Proteasome-IN-4	Others	Others
	Proteasome-IN-4 是一种良好的非共价 proteasome 抑制剂 (IC50= 8.39 nM)。Proteasome-IN-4 对 RPMI-8226、MM-1S 和 MV-4-11 细胞系具有较强的抗增殖活性。Proteasome-IN-4 可用于癌症研究。
T81202	SARS-CoV-2-IN-69	SARS-CoV	Microbiology/Virology
	SARS-CoV-2-IN-69 (Compound 7E)是一种SARS-CoV-2的非共价抑制剂，具有7.4 μM的EC50值。它有效针对SARS-CoV-2的主蛋白酶(Mpro)并作为木瓜蛋白酶(PLpro)的非共价抑制剂。
T60874	Avibactam sodium dihydrate	Others	Others
	Avibactam sodium (NXL-104) dihydrate 抑制 CTX-M-15和 β-内酰胺酶 TEM-1，IC50值分别为 5 nM 和 8 nM。Avibactam sodium (NXL-104) dihydrate 是非 β-内酰胺 β-内酰胺酶的可逆共价抑制剂。
T79050	JBI-589	Others	Others
	JBI-589为一种非共价、选择性PAD4抑制剂，可降低CXCR2表达，阻断中性粒细胞趋化性；此外，JBI-589能减小原发肿瘤体积及其转移，并增强检查点抑制剂的抗肿瘤效果。
T63920	LSD1-IN-19	Others	Others
	LSD1-IN-19 (compound 29) 是一种选择性的、有效的、非共价的 LSD1 抑制剂 (Ki: 0.108 μM, KD: 0.068 μM)。LSD1-IN-19 在 THP-1 白血病细胞和 MDA-MB-231 乳腺癌细胞中具有抗增殖效果，其72h 的IC50值分别为 0.17 和 0.40 μM。
T79376	SARS-CoV-2 3CLpro-IN-19	SARS-CoV	Microbiology/Virology
	SARS-CoV-2 3CLpro-IN-19 (Compound C5a)为非共价、非肽类SARS-CoV-2 3CLpro抑制剂，具IC50s值为0.7μM。该化合物对Omicron亚变体（包括BA.5、BQ.1.1及XBB.1.5）在人细胞内的感染显示出具有广谱抗病毒活性，其EC50值介于30-69 nM。

化合物

Cat.No: T8371

Target: Virus Protease, SARS-CoV

Salcaprozate sodium

Cat.No: T8926

Synonym: 8-(2-羟基苯甲酰胺基)辛酸钠,SNAC

Target: Others

Samuraciclib hydrochloride

Cat.No: T10898

Synonym: ICEC0942 hydrochloride,CT7001 hydrochloride

Target: Apoptosis, CDK

Cat.No: T11469

Target: DNA Methyltransferase

Cat.No: T9303

Target: Ras

Cat.No: T17389

Target: Others, ADC Linker

Cat.No: T8431

Target: EGFR

Cat.No: T40292

Synonym: NVP-JDQ443,JDQ-443,Opnurasib

Target: Ras

GOT1 inhibitor-1

Cat.No: T8766

Synonym: GOT1 inhibitor 2c

Target: Others

Cat.No: T11724

Target: Lipase

Cat.No: T36287

Target: BTK

Cat.No: T9573

Target: DNA Methyltransferase

Cat.No: T5461

Target: DUB

Cat.No: T40063

Target: Nrf2

Cat.No: T72062

Target: Ras

Thailanstatin A

Cat.No: T38889

Target: Others, ADC Cytotoxin

Cat.No: T10534

Target: EGFR

Cat.No: T11159

Target: EGFR

Cat.No: T69545

Target: Others

Cat.No: T14915

Target: CDK

Cat.No: T12621

Target: Others

Cat.No: T12621L

Target: DUB

ZM223 hydrochloride

Cat.No: T63800

Target: Others

Sulfo-SMPB sodium

Cat.No: T19568

Target: Others, ADC Linker

Avibactam free acid

Cat.No: T10422

Synonym: NXL-104 free acid

Target: Antibacterial

(R)-Pirtobrutinib

Cat.No: T35844

Target: Others

ZM223 hydrochloride (2031177-48-5 free base)

Cat.No: T13412L

Synonym: ZM223 hydrochloride

Target: Serine Protease

Cat.No: T73510

Target: Others

(R)-GSK-3685032

Cat.No: T39648

Target: Others

Ensitrelvir fumarate

Cat.No: T40358

Synonym: S-217622 fumarate

Target: Others

Bisnorcymserine

Cat.No: T26827

Synonym: N1 N8 Bisnorcymserine,N1N8Bisnorcymserine,N1-N8-Bisnorcymserine

Target: Others

Cat.No: T39859

Target: Others

SB-435495 hydrochloride

Cat.No: T75255L

Target: Others

Cat.No: T82137

Target: Others

SB-435495 ditartrate

Cat.No: T75255L1

Target: Others

Cat.No: T39430

Target: Others

Cat.No: T79344

Target: SARS-CoV

Cat.No: T37085

Target: Others

Cat.No: T79345

Target: SARS-CoV

Cat.No: T79346

Target: SARS-CoV

Cat.No: T75109

Target: Others

MAT-POS-e194df51-1

Cat.No: T81849

Target: SARS-CoV

Cat.No: T74849

Target: Others

Cat.No: T9671

Target: Others

Proteasome-IN-4

Cat.No: T72762

Target: Others

SARS-CoV-2-IN-69

Cat.No: T81202

Target: SARS-CoV

Avibactam sodium dihydrate

Cat.No: T60874

Target: Others

Cat.No: T79050

Target: Others

Cat.No: T63920

Target: Others

SARS-CoV-2 3CLpro-IN-19

Cat.No: T79376

Target: SARS-CoV

Cat. No.	Product Name	Target	Signaling Pathways
T8307	Hydroxy-α-sanshool 羟基-α-山椒素,Hydroxy-α-sanshool	Endogenous Metabolite; TRP/TRPV Channel	Membrane transporter/Ion channel; Metabolism
	Hydroxy-α-sanshool 是分离自胡椒的烷基酰胺，作为 TRPA1的共价激动剂和 TRPV1的非共价激动剂，EC50分别为69和 1.1 µM。

天然产物

Hydroxy-α-sanshool

Cat.No: T8307

Synonym: 羟基-α-山椒素,Hydroxy-α-sanshool

Target: Endogenous Metabolite, TRP/TRPV Channel

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPH-00088	Expansin-B1 Protein, Arabidopsis thaliana, Recombinant (His) EXPB1,Expansin-B1,Ath-ExpBeta-1.5,Beta-expansin-1	Arabidopsis thaliana	E. coli
	May cause loosening and extension of plant cell walls by disrupting non-covalent bonding between cellulose microfibrils and matrix glucans. No enzymatic activity has been found.
TMPH-00155	Barstar Protein, Bacillus amyloliquefaciens, Recombinant (His & Myc) Barstar,Ribonuclease inhibitor	Bacillus amyloliquefaciens	E. coli
	Inhibitor of the ribonuclease barnase. Forms a one-to-one non-covalent complex. Barstar Protein, Bacillus amyloliquefaciens, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 17.7 kDa and the accession number is P11540.
TMPH-03601	Streptavidin Protein, S. avidinii, Recombinant (His) Streptavidin	Streptomyces avidinii	P. pastoris (Yeast)
	The biological function of streptavidin is not known. Forms a strong non-covalent specific complex with biotin (one molecule of biotin per subunit of streptavidin). Streptavidin Protein, S. avidinii, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 18.5 kDa and the accession number is P22629.
TMPH-00087	Expansin-A1 Protein, Arabidopsis thaliana, Recombinant (His & Myc) Expansin-A1,Alpha-expansin-1,EXPA1,Ath-ExpAlpha-1.2	Arabidopsis thaliana	E. coli
	Causes loosening and extension of plant cell walls by disrupting non-covalent bonding between cellulose microfibrils and matrix glucans. No enzymatic activity has been found. Expansin-A1 Protein, Arabidopsis thaliana, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 32.2 kDa and the accession number is Q9C554.
TMPJ-01362	UBAP1 Protein, Human, Recombinant (His) Nasopharyngeal Carcinoma-Associated Gene 20 Protein,UBAP1,Ub...	Human	E. coli
	Ubiquitin-Associated Protein 1 (UBAP1) belongs to the UBA domain family. Members of this family are related to ubiquitin and the ubiquitination pathway. Because of their cytogenetic location, this UBA domain family member is being studied as a putative target for mutation in nasopharyngeal carcinomas. UBAP1 is highly expressed in the heart, brain, placenta, lung, skeletal muscle, liver, and pancreas. UBAP1 consists of two UBA domains and one UMA domain. The ubiquitin associated domain is through...
TMPY-00323	Hepatitis C virus (HCV-1a) NS3 protease/helicase immunodominant region Protein (aa 1356-1459, GST) NS3	HCV	E. coli
	HCV NS3 displays three enzymatic activities: serine protease, NTPase, and RNA helicase. HCV NS3 serine protease, in association with NS4A, is responsible for the cleavages of NS3-NS4A, NS4A-NS4B, NS4B-NS5A, and NS5A-NS5B. HCV NS3 RNA helicase binds to RNA and unwinds dsRNA in the 3' to 5' direction, and likely RNA stable secondary structure in the template strand (By similarity). Cleaves and inhibits the host antiviral protein MAVS. NS3/NS4A complex also prevents phosphorylation of human IRF3, t...
TMPJ-01089	TFF1 Protein, Mouse, Recombinant (His) Bcei,Protein pS2,Ps2,Trefoil factor 1,Tff1	Mouse	HEK293 Cells
	Trefoil Factor 1 (TFF1) belongs to the three structurally related secreted proteins that contain trefoil domains.TFF1 is an approximately peptide that has an important effect in epithelial regeneration and wound healing.It originates from musculus and highly expressed by goblet cells of the gastric and intestinal mucosa and by conjunctival goblet cells. TFF1 is a copper-binding protein that can form disulfide-linked homodimers, associate into disulfide-linked complexes with Gastrokine 2, and fo...
TMPJ-01055	HBA1 Protein, Human, Recombinant (His) α-globin,Hemoglobin subunit alpha,HBH,HBA-T3,Alpha-globin,He...	Human	E. coli
	Hemoglobin subunit alpha 1 (HBA1), also known as α2β2, is a hetero-tetramer consisting of two α and two β subunits held together by non-covalent interactions. Each subunit contains a heme group with an iron atom in the Fe2+ state. Cooperativity of Hemoglobin (Hb) in binding with O2 and allosteric regulatory binding properties with CO2, H+, Cl−, and 2,3-DPG (2,3-bisphosphoglycerate) are based on subunit interactions. HBA1 is the most common type of Hb in adult humans, which mediates the transport...
TMPJ-01100	UBE2V1 Protein, Human, Recombinant (His) TRAF6-Regulated IKK Activator 1 Beta Uev1A,P/OKcl.19,TRAF6-R...	Human	E. coli
	Ubiquitin-Conjugating Enzyme Variant 1a (UBE2V1) is a member of the Ubiquitin-conjugating (E2) enzyme family. The E2 catalytic core domain of UBE2V1 lacks an active site cysteine residue, rendering it catalytically inactive on its own. However, in the cytoplasm UBE2V1 is able to form a catalytically active complex with UBE2N/Ubc13, which mediates the synthesis Lys63-linked Ubiquitin chains and is required for NF-kappa B activation. UBE2V1 is required for UBE2N (Ubc13)/UBE2V1 Complex-dependent Ly...
TMPH-00651	Lpp Protein, E. coli, Recombinant (His & KSI) Major outer membrane lipoprotein Lpp,Braun lipoprotein,Murei...	E. coli	E. coli
	An outer membrane lipoprotein that controls the distance between the inner and outer membranes; adding residues to Lpp increases the width of the periplasm. The only protein known to be covalently linked to the peptidoglycan network (PGN). Also non-covalently binds the PGN. The link between the cell outer membrane and PGN contributes to the maintenance of the structural and functional integrity of the cell envelope, and maintains the correct distance between the PGN and the outer membrane. The m...

重组蛋白

Expansin-B1 Protein, Arabidopsis thaliana, Recombinant (His)

Cat.No: TMPH-00088

Species: Arabidopsis thaliana

Expression System: E. coli

Barstar Protein, Bacillus amyloliquefaciens, Recombinant (His & Myc)

Cat.No: TMPH-00155

Species: Bacillus amyloliquefaciens

Expression System: E. coli

Streptavidin Protein, S. avidinii, Recombinant (His)

Cat.No: TMPH-03601

Species: Streptomyces avidinii

Expression System: P. pastoris (Yeast)

Expansin-A1 Protein, Arabidopsis thaliana, Recombinant (His & Myc)

Cat.No: TMPH-00087

Species: Arabidopsis thaliana

Expression System: E. coli

UBAP1 Protein, Human, Recombinant (His)

Cat.No: TMPJ-01362

Species: Human

Expression System: E. coli

Hepatitis C virus (HCV-1a) NS3 protease/helicase immunodominant region Protein (aa 1356-1459, GST)

Cat.No: TMPY-00323

Species: HCV

Expression System: E. coli

TFF1 Protein, Mouse, Recombinant (His)

Cat.No: TMPJ-01089

Species: Mouse

Expression System: HEK293 Cells

HBA1 Protein, Human, Recombinant (His)

Cat.No: TMPJ-01055

Species: Human

Expression System: E. coli

UBE2V1 Protein, Human, Recombinant (His)

Cat.No: TMPJ-01100

Species: Human

Expression System: E. coli

Lpp Protein, E. coli, Recombinant (His & KSI)

Cat.No: TMPH-00651

Species: E. coli

Expression System: E. coli

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