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Search Results for " lipopolysaccharide "

Targets Recommended: Endogenous Metabolite

58

抑制剂 & 化合物

81

天然产物

24

重组蛋白

2

同位素标记化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T37859	SY-640	Endogenous Metabolite	Metabolism
	SY-640 是一种乙酰胺衍生物，显示出有效的保肝作用。SY-640 可缓解由脂多糖和痤疮丙酸杆菌诱导的小鼠肝损伤。
T8235	L-732138	Neurokinin receptor	GPCR/G Protein; Neuroscience
	L-732138 是选择性有效和竞争性神经激肽-1受体拮抗剂，IC50为 2.3 nM，可减轻痛觉过敏并具有抗肿瘤作用。它在克隆的人 NK-1受体中的效力比在克隆大鼠 NK-1受体中高 200 倍，比人类 NK-2 和 NK-3 受体高 1000 倍以上。
T21785	AG957	Bcr-Abl	Angiogenesis; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors
	Tyrphostin AG957 是一种酪氨酸激酶抑制剂，具有抗BCR/ABL 酪氨酸激酶活性。它能够抑制p210bcr/abl 酶活性 (IC50:2.9 μM)。
T2923	Apremilast 阿普斯特,CC-10004,阿普司特	Apoptosis; TNF; PDE	Apoptosis; Metabolism
	Apremilast (CC-10004) 是一种口服有效的磷酸二酯酶 4 抑制剂，IC50为 74 nM。它抑制脂多糖释放TNF-α，IC50为 104 nM。
T16501	PF-3644022	p38 MAPK; Serine Protease; MAPK	MAPK; Proteases/Proteasome
	PF-3644022 是可口服的，具有 ATP 竞争性的MAPKAPK2 (MK2)选择性抑制剂，IC50为 5.2 nM，Ki 为 3 nM。它有效抑制 TNFα 的产生并具有抗炎作用，还抑制 MK3 和 p38 调节/激活激酶，IC50分别为 53 和 5.0 nM。
T0947	Dexamethasone acetate Dexamethasone 21-acetate,醋酸地塞米松,Dexamethason acetate,NSC 39471	Glucocorticoid Receptor; Mitophagy; IL Receptor; Annexin A; NOS; Antibacterial; Autophagy; ADC Cytotoxin	Antibody-drug Conjugate/ADC Related; Autophagy; Endocrinology/Hormones; GPCR/G Protein; Immunology/Inflammation; Microbiology/Virology
	Dexamethasone acetate (NSC 39471) 是一种糖皮质素类甾体，有抗炎和免疫抑制活性。它可研究眼部感染。
T21233	Dihydrolipoic acid Reduced thioctic acid,Reduced lipoic acid,DHLA,USAF XR-12,6,8-Dihydrothioctic acid,二氢硫辛酸	Antioxidant	oxidation-reduction
	Dihydrolipoic acid (USAF XR-12) 是高效的抗氧化剂，对所有以氧为中心的自由基都有很强的清除能力。它在多种疾病中表现出抗炎特性。在 LPS 诱导的疾病行为大鼠中，它通过 ERK/Nrf2/HO-1/ROS/NLRP3 通路发挥预防作用。它还可以可用于抑郁症的研究。
T5101	BW-A 78U BW-A78U	PDE	Metabolism
	BW-A 78U 抑制 PDE4，其 IC50值为 3 μM。
TP1050L	Murepavadin acetate(944252-63-5 free base)	Antibacterial; Antibiotic	Microbiology/Virology
	Murepavadin acetate(944252-63-5 free base) 是一种有效且特异性的抗生素，用于治疗由铜绿假单胞菌引起的细菌感染。 Murepavadin acetate 靶向脂多糖转运蛋白 D。
T11348	G907	Antibiotic	Microbiology/Virology
	G907 是一种具有选择性和有效性的小分子ATP 结合盒 (ABC) 转运蛋白 MsbA 的拮抗剂，具有杀菌活性，可将 MsbA 捕获在朝内的脂多糖中。 G907 对大肠杆菌 MsbA 有抑制作用， IC50 值为 18 nM。
T23636	Adenosine N1-oxide ANO,1-Oxoadenosine,Adenosine N1 oxide,Adenosine, 1-oxide,腺苷氮氧化物	Immunology/Inflammation related	Immunology/Inflammation
	Adenosine N1-oxide (1-Oxoadenosine) 是在蜂王浆中发现的腺苷 N1-氧化物，可抑制活化的巨噬细胞分泌炎症介质，并降低脂多糖 (LPS) 诱导的内毒素休克的致死率。
T60396	JMS-053	Phosphatase	Metabolism
	JMS-053 是一种具有有效性和选择性的磷酸酶 DUSP3 抑制剂，抑制 PTP4A3、 PTP4A1 、 PTP4A2 和 CDC25B，抑制癌细胞迁移和球体生长，避免血管内皮生长因子或脂多糖对微血管内皮屏障功能的破坏。
T73286	SRI-42127	HuR	Chromatin/Epigenetic
	SRI-42127 是一种新型 RNA 调节因子 HuR 的小分子抑制剂，抑制肿瘤生长，可减弱脂多糖诱导的神经炎症模型中的神经胶质活化，通过抑制神经炎症反应来减轻神经损伤后的神经性疼痛。
T60472	GSK-3β inhibitor 12	GSK-3	PI3K/Akt/mTOR signaling; Stem Cells
	GSK-3β inhibitor 12 是一种选择性 GSK-3β 的抑制剂。GSK-3β inhibitor 12 抑制 49.11% 25 μM 的 GSK-3β 的活性和37.11% 50 μM 的 GSK-3β 的活性。GSK-3β inhibitor 12 可用于研究有脂多糖诱导的帕金森。
T61042	TBT1	Antibacterial	Microbiology/Virology
	TBT1 是一种新型 MsbA 转运蛋白抑制剂，也是 MsbA ATPase 刺激剂，抑制脂多糖合成途径中ATP依赖性转运蛋白的合成。TBT1 具有抗菌活性，抑制沙门氏菌、铜绿假单胞菌、大肠杆菌和金黄色葡萄球菌，可用于研究细菌感染。
T4062	CAY10602	Sirtuin	Chromatin/Epigenetic; DNA Damage/DNA Repair
	CAY10602 是一种SIRT1激活剂，可剂量依赖性地抑制 THP-1 细胞中脂多糖对 TNF-α 的 NF-κB 依赖性诱导。
T38261	Sparstolonin B	TLR; HIV Protease	Immunology/Inflammation; Microbiology/Virology; Proteases/Proteasome
	Sparstolonin B 是一种选择性 TLR2 和 TLR4 拮抗剂，是一种是一种从 Sparganium stoloniferum 和 Scirpus yagara 的块茎中分离出的异香豆素化合物，具有抗 HIV 、抗癌、抗肿瘤和抗炎活性，抑制选择性Toll样受体，抑制游离脂肪酸棕榈酸酯诱导的软骨细胞炎症并减轻肥胖小鼠的创伤后关节炎，抑制脂多糖诱导的 3T3-L1 脂肪细胞炎症，可用于研究验证和乳腺癌。
T70354	E 5531	Others	Others
	E 5531 is a novel synthetic lipopolysaccharide antagonist.
T24262	KL-1156	Others	Others
	KL-1156 is an NF-κB inhibitor. It is also a lipopolysaccharide (LPS)-induced nitric oxide production inhibitor.
T25846	N-Acylkansosamine	Others	Others
	N-Acylkansosamine is a N-acylamino sugar isolated from trehalose-containing lipopolysaccharide antigens of Mycobacterium kansasii.
T32948	Lumin
	Lumin is a cyanine dye that enhances interleukin 12-dependent interferon gamma production by lipopolysaccharide-stimulated mouse splenocytes.
T69210	Chondrocurine	Others	Others
	Chondrocurine is a biochemical that Inhibits quick death of mice treated with bacillus Calmetta Guerin & elicited with lipopolysaccharide.
T28681	SB220025 SB-220025,SB 220025	Others	Others
	SB220025, a specific and potent inhibitor of human p38 mitogen-activated protein kinase, reduces the production of tumor necrosis factor induced by lipopolysaccharide.
T61157	ABAI-30	Others	Others
	ABAI-30 is a highly potent and orally bioavailable anti-inflammatory compound that efficiently suppresses nitric oxide (NO) production in lipopolysaccharide (LPS) activated RAW264.7 cells [1].
T70367	SNU-BP	Others	Others
	SNU-BP is an agonist of PPAR-gamma, inhibiting lipopolysaccharide (LPS)-induced NO production and pro-inflammatory cytokines. SNU-BP potentiates interleukin-4-induced arginase-1 expression, and promotes microglial polarization toward an M2 anti-inflammatory phenotype.
T28241	Ono 3403 Ono3403,Ono-3403	Others	Others
	Ono 3403 is a synthetic serine protease inhibitor. Ono 3403 inhibits lipopolysaccharide-induced tumor necrosis factor-alpha and nitric oxide production. ONO-3403 also has an antitumor effect on malignant tumors.
T40225	JH-X-119-01 hydrochloride	Others	Others
	JH-X-119-01 hydrochloride is a potent and selective inhibitor of interleukin-1 receptor-associated kinases 1 (IRAK1). It effectively alleviates lipopolysaccharide (LPS)-induced sepsis in mice.
T62339	MsbA-IN-2	Others	Others
	MsbA-IN-2 是一种脂多糖转运蛋白 MsbA 的有效抑制剂，能够作用于 E. coliMsbA (IC50: 2 nM)。
T37901	UDP-N-acetyl-D-Glucosamine (sodium salt hydrate)	Others	Others
	UDP-N-acetyl-D-Glucosamine is a natural nucleotide sugar that is used by glycosyltransferases to transfer N-acetyl-D-glucosamine residues to substrates.1It is an important component of antibiotic biosynthesis pathways in fungi and lipopolysaccharide production in bacteria.2,3 1.Roseman, S.Reflections on glycobiologyJ. Biol. Chem.276(45)41527-41542(2001) 2.Kudo, F., and Eguchi, T.Biosynthetic genes for aminoglycoside antibioticsJ. Antibiot. (Tokyo)62(9)471-481(2009) 3.Mulrooney, E.F., Poon, K.K.,...
T83049	Anti-inflammatory agent 63	Others	Others
	Anti-inflammatory agent 63，在RAW264.7细胞中对脂多糖 (LPS) 诱导的一氧化氮 (NO) 产生显示最佳抑制效果，其半抑制浓度(EC50)为5.33±0.57 μM。
T70268	3A-MPLA	Others	Others
	Monophosphoryl lipid A (MPLA) is a natural agonist for the toll-like receptor-4 (TLR4). It is useful as an adjuvant in immunization. MPLA is a safe prophylactic agent and has immunotherapeutic applications. It induces tumor necrosis factor and interleukin (IL)-1β, however not as efficient as lipopolysaccharide (LPS). MPLA improves immune response during bacterial sepsis infection.
T4186	AC-264613 AC264613	Protease-activated Receptor	GPCR/G Protein
	AC-264613 是一种选择性蛋白酶激活受体 (PAR-2) 激动剂，pEC50为 7.5。
T38945	Carboxy-PTIO	Others	Others
	Carboxy-PTIO is a highly effective nitric oxide (NO) scavenger known for its rapid reaction rate with NO, resulting in the formation of nitric dioxide (NO2). Its direct scavenging action against NO plays a crucial role in preventing hypotension and endotoxic shock, particularly in lipopolysaccharide-stimulated rat models.
T37989	D-Sedoheptulose-7-phosphate (barium salt)	Others	Others
	D-Sedoheptulose-7-phosphate is an intermediate in the pentose phosphate pathway. [1] [2] In this pathway, transaldolase catalyzes the transfer of a three carbon dihydroxyacetone moiety from D-sedoheptulose-7-phosphate to glyceraldehyde-3-phosphate to generate D-fructose-6-phosphate . D-Sedoheptulose-7-phosphate is also an intermediate in carbon fixation in photosynthetic organisms, as well as in the biosynthesis of lipopolysaccharide, amino acids, secondary metabolites, and antibiotics. [3]
T84511	Oxalomalic acid trisodium Oxalomalate trisodium	Others	Others
	Oxalomalic Acid (Oxalomalate) trisodium是一种抑制剂，针对乌头酸酶(aconitase)和NADP依赖性异柠檬酸脱氢酶(NADP-dependent isocitrate dehydrogenase)。它能够抑制脂多糖激活的J774巨噬细胞内亚硝酸盐的产生及iNOS蛋白的表达。
T79981	Nitric oxide production-IN-1	NO Synthase	Immunology/Inflammation
	Nitric oxide production-IN-1（Compound 1）是从Tupistra chinensis中提取的一种NO产生抑制剂，能够抑制脂多糖诱导的大鼠腹腔巨噬细胞NO产量。
T37988	D-Ribulose-5-phosphate (sodium salt) Ru5P,D-Ribulose-5-phosphate (sodium salt)	Others	Others
	D-Ribulose-5-phosphate is an intermediate in the pentose phosphate pathway. [1][2] It can be derived from 6-phosphogluconate by a dehydrogenase or from xylulose 5-phosphate by ribulose phosphate 3-epimerase. D-Ribulose-5-phosphate is also an intermediate in carbon fixation in photosynthetic organisms as well as in the biosynthesis of lipopolysaccharide, amino acids, secondary metabolites, and antibiotics.[3]
T72414	Antimicrobial agent-8	Others	Others
	Antimicrobial agent-8 是一种有效的抗菌剂，对革兰氏阴性和革兰氏阳性菌表现出强大的抗菌活性，MIC 范围为 2-8 μg/mL。Antimicrobial agent-8 对脂多糖引起的炎症表现出抗炎活性。
T73667	Motapizone	Others	Others
	Motapizone (NAT 05-239) 是一种选择性 PDE3抑制剂。Motapizone 适度抑制脂多糖 (LPS) 诱导的肺泡巨噬细胞中细胞因子的释放。Motapizone 还通过增加细胞内 cAMP 来抑制人血小板聚集。
T75011	STING-IN-5	STING	Immunology/Inflammation
	STING-IN-5为有效STING抑制剂，IC50达1.15 μM，能在巨噬细胞内抑制LSP诱导之NO合成，从而抑制炎症反应，主用于抗炎疾病与败血症研究。
T74953	Antimicrobial agent-7	Others	Others
	Antimicrobial agent-7 (Compound 12) 为一化合物，对革兰氏阴性及革兰氏阳性菌展现出显著的抗菌能力，MIC值介于 2-8 μg/mL 之间。此外，该化合物还对脂多糖引发的炎症有着抗炎作用。
TP1341	Polymyxin B nonapeptide
	Polymyxin B nonapeptide, a cationic cyclic peptide derived by enzymatic processing from the naturally occurring peptide polymyxin B, is able to increase the permeability of the outer membrane of Gram-negative bacteria toward hydrophobic antibiotics probab
T72412	Antimicrobial agent-5	Others	Others
	Antimicrobial agent-5 是一种强效抗菌剂，对革兰氏阳性菌/阴性菌展示出良好的细胞选择性。通过阻断LPS与CD14/TLR4受体之间的交互作用，Antimicrobial agent-5 显示出抗炎活性并能缓解LPS引发的炎症反应。
T73497	GSK761	Others	Others
	GSK761作为Sp 140核体蛋白（SP140）的选择性抑制剂，其IC50值达到77.79 nM。它有效减少了单核细胞向炎性巨噬细胞的分化及脂多糖（LPS）诱导的炎症反应。此外，GSK761通过阻断SP140活动，促进CD206+调节性巨噬细胞的形成。
T75996	Murepavadin TFA
	Murepavadin (POL7080) (TFA)，一种 14 个氨基酸的环肽，是一种高效的特异性抗生素。Murepavadin 对P. aeruginosa 表现出有效的抗菌活性。MIC50和MIC90值均为 0.12 mg/L。Murepavadin 还可以靶向脂多糖转运蛋白 D。Murepavadin 可用于细菌耐药性的研究。
T80361	SpHistin
	SpHistin为一种抗菌肽(AMP)。该化合物能够结合LPS并增加细菌膜的透化性。SpHistin与利福平与阿奇霉素结合时，能够促进这些抗生素的细胞内摄取，从而提高对铜绿假单胞菌的杀菌效果。
T83226	A3373	Phospholipase	Metabolism
	A3373 是新型 PLD1 和 PLD2 抑制剂，对 PLD1 的 IC50 为 325 nM ，对 PLD2 的 IC50 为 15.15 µM，能够有效抑制 LPS 诱导的免疫反应，并在自身免疫性关节炎、骨脱矿及破骨细胞生成等方面发挥关键作用。
T69451	R-130823	Others	Others
	R-130823 is a ighly selective inhibition against mitogen-activated protein kinase p38alpha (IC50=22 nM). The release of tumor necrosis factor-alpha, interleukin-1beta, -6 and -8 was inhibited in lipopolysaccharide-stimulated human blood pretreated by R-130823 , with IC50 values of 0.089, 0.066, 0.95 and 0.16 microM, respectively. R-130823 reduced the established hind paw swelling in rat adjuvant-induced arthritis, while methotrexate showed no suppression. In the same model, R-130823 ameliorated ...
T22506	3,4-DAA	NOS	Immunology/Inflammation
	3,4-DAA 具有抗炎活性，可改善急性肝同种异体移植损伤，通过抑制肠道屏障功能障碍和 NF-κB 活化来缓解严重的急性胰腺炎。3,4-DAA 抑制由 IFN-γ 和脂多糖诱导的 EOC20 细胞诱导型一氧化氮合酶 (iNOS) 发挥作用。
T79484	Nrf2 activator-8	Others	Others
	Nrf2 activator-8（化合物 10e）作为一种效能显著的Nrf2激活剂（EC50=37.9 nM），在BV-2微神经胶质细胞中展现出优异的抗氧化及抗炎效应。此外，Nrf2 activator-8可有效逆转脂多糖（LPS）诱导的小鼠神经炎症模型中的空间记忆缺失。

化合物

Cat.No: T37859

Target: Endogenous Metabolite

Cat.No: T8235

Target: Neurokinin receptor

Cat.No: T21785

Target: Bcr-Abl

Cat.No: T2923

Synonym: 阿普斯特,CC-10004,阿普司特

Target: Apoptosis, TNF, PDE

Cat.No: T16501

Target: p38 MAPK, Serine Protease, MAPK

Dexamethasone acetate

Cat.No: T0947

Synonym: Dexamethasone 21-acetate,醋酸地塞米松,Dexamethason acetate,NSC 39471

Target: Glucocorticoid Receptor, Mitophagy, IL Receptor, Annexin A, NOS, Antibacterial, Autophagy, ADC Cytotoxin

Dihydrolipoic acid

Cat.No: T21233

Synonym: Reduced thioctic acid,Reduced lipoic acid,DHLA,USAF XR-12,6,8-Dihydrothioctic acid,二氢硫辛酸

Target: Antioxidant

Cat.No: T5101

Synonym: BW-A78U

Target: PDE

Murepavadin acetate(944252-63-5 free base)

Cat.No: TP1050L

Target: Antibacterial, Antibiotic

Cat.No: T11348

Target: Antibiotic

Adenosine N1-oxide

Cat.No: T23636

Synonym: ANO,1-Oxoadenosine,Adenosine N1 oxide,Adenosine, 1-oxide,腺苷氮氧化物

Target: Immunology/Inflammation related

Cat.No: T60396

Target: Phosphatase

Cat.No: T73286

Target: HuR

GSK-3β inhibitor 12

Cat.No: T60472

Target: GSK-3

Cat.No: T61042

Target: Antibacterial

Cat.No: T4062

Target: Sirtuin

Cat.No: T38261

Target: TLR, HIV Protease

Cat.No: T70354

Target: Others

Cat.No: T24262

Target: Others

N-Acylkansosamine

Cat.No: T25846

Target: Others

Cat.No: T32948

Cat.No: T69210

Target: Others

Cat.No: T28681

Synonym: SB-220025,SB 220025

Target: Others

Cat.No: T61157

Target: Others

Cat.No: T70367

Target: Others

Cat.No: T28241

Synonym: Ono3403,Ono-3403

Target: Others

JH-X-119-01 hydrochloride

Cat.No: T40225

Target: Others

Cat.No: T62339

Target: Others

UDP-N-acetyl-D-Glucosamine (sodium salt hydrate)

Cat.No: T37901

Target: Others

Anti-inflammatory agent 63

Cat.No: T83049

Target: Others

Cat.No: T70268

Target: Others

Cat.No: T4186

Synonym: AC264613

Target: Protease-activated Receptor

Cat.No: T38945

Target: Others

D-Sedoheptulose-7-phosphate (barium salt)

Cat.No: T37989

Target: Others

Oxalomalic acid trisodium

Cat.No: T84511

Synonym: Oxalomalate trisodium

Target: Others

Nitric oxide production-IN-1

Cat.No: T79981

Target: NO Synthase

D-Ribulose-5-phosphate (sodium salt)

Cat.No: T37988

Synonym: Ru5P,D-Ribulose-5-phosphate (sodium salt)

Target: Others

Antimicrobial agent-8

Cat.No: T72414

Target: Others

Cat.No: T73667

Target: Others

Cat.No: T75011

Target: STING

Antimicrobial agent-7

Cat.No: T74953

Target: Others

Polymyxin B nonapeptide

Cat.No: TP1341

Antimicrobial agent-5

Cat.No: T72412

Target: Others

Cat.No: T73497

Target: Others

Murepavadin TFA

Cat.No: T75996

Cat.No: T80361

Cat.No: T83226

Target: Phospholipase

Cat.No: T69451

Target: Others

Cat.No: T22506

Target: NOS

Nrf2 activator-8

Cat.No: T79484

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T41078	Lipopolysaccharides, Escherichiacoli Lipopolysaccharide, E. coli O111:B4	Others	Others
	Lipopolysaccharides, Escherichiacoli (E. coli O111:B4) 是革兰氏阴性细菌细胞壁的一种特有成分，由脂质A、寡糖核心和 O -特异性多糖 (O-antigen) 3个区域组成。Lipopolysaccharides, Escherichiacoli 有利于维持细胞外膜的完整性，保护细菌免受胆汁盐和脂类抗生素的破坏。Lipopolysaccharides, Escherichiacoli 是一种高免疫原性抗原，可以增强免疫反应，可以用于炎症模型构建。
TN1291	7,3',4'-Tri-O-methylluteolin 5-Hydroxy-3',4',7-trimethoxyflavone,木犀草素-7,3',4'-三甲醚	TNF; COX; Interleukin	Apoptosis; Immunology/Inflammation; Neuroscience
	7,3',4'-Tri-O-methylluteolin (5-Hydroxy-3',4',7-trimethoxyflavone) 是来自草药马鞭草科的一种类黄酮，具有抗炎，解热，镇咳，抗糖尿病、抗癌和抗黑素生成特性。它以浓度依赖方式明显抑制促炎细胞因子，可显著降低在转录水平的诱导型一氧化氮合酶和环加氧酶-2 的 mRNA 表达。
T11855	Lipopolysaccharides 脂多糖,LPS	Others	Others
	Lipopolysaccharides (LPS) 是革兰氏阴性细菌细胞壁的一种特有成分，由脂质A、寡糖核心和 O -特异性多糖 (O-antigen) 3个区域组成。Lipopolysaccharides 有利于维持细胞外膜的完整性，保护细菌免受胆汁盐和脂类抗生素的破坏。Lipopolysaccharides 是一种高免疫原性抗原，可以增强免疫反应，可以用于炎症模型构建。
TN1021	Secologanic acid	NO Synthase	Immunology/Inflammation
	Secologanic acid 是裂环烯醚萜苷的一种。
TWS0704	N-Methylnuciferine	Others	Others
	N-Methylnuciferine 是一种从Lotus Plumule提取的生物碱，可改善脂多糖诱导的抑郁样行为。
TN1933	Mitraphylline 帽柱木菲碱,帽柱叶碱	IL Receptor; TNF; NF-κB	Apoptosis; Immunology/Inflammation; NF-κB
	Mitraphylline 是一种绒毛钩藤中主要的五环吲哚类生物碱，可阻碍脂多糖介导的原代人中性粒细胞活化。
T29352	2-Hydroxydecanoic acid (±)-α-hydroxy Decanoic Acid,羟基癸酸,(±)-2-hydroxy Decanoic Acid,alpha-Hydroxydecanoic acid,2-hydroxy Decylic Acid,2-Hydroxydecanoate	Others	Others
	2-Hydroxydecanoic acid ((±)-α-hydroxy Decanoic Acid) 是一种在好氧菌 P. ovalis 的脂多糖部分的亲脂部分中发现的脂肪酸。
TN2167	Rutaevin	Reactive Oxygen Species; NO Synthase	Immunology/Inflammation; Metabolism; NF-κB
	Rutaevin 从Euodia rutaecarpa 中分离。它对 Raw 264.7 巨噬细胞中 LPS 诱导的NO 产生具有抑制作用。
T5798	Euphorbia Factor L2 千金子素L2,euphorbiafactor L2,大戟因子L2	Apoptosis; NF-κB	Apoptosis; NF-κB
	Euphorbia Factor L2 是从大戟种子中分离得到的一种赤藓烷二萜，显示强烈的细胞毒性并通过线粒体途径诱导细胞凋亡，具有抗癌活性。
T3383	Cimifugin 升麻素,Cimitin	Others	Others
	Cimifugin (Cimitin) 是中草药Saposhnikovia divaricate 的一种生物活性成分。它能够调节紧密连接减少上皮衍生的主动关键因子，对过敏性炎症产生抑制作用。
T3S1692	Octahydrocurcumin	Anti-infection; NF-κB; Reactive Oxygen Species; ROS	Immunology/Inflammation; Metabolism; Microbiology/Virology; NF-κB
	Octahydrocurcumin 是一种姜黄素的氢化衍生物，是姜黄素的代谢物。
T7053	p-Hydroxycinnamic acid p-Coumaric acid,p-Cumaric acid,p-Hydroxy-cinnamic acid,对羟基肉桂酸,NSC 59260	Thrombin; Endogenous Metabolite; Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation; Metabolism; Proteases/Proteasome
	p-Hydroxycinnamic acid (NSC-59260) 是常见的食用酚，可抑制血小板活性，对血栓素 B2 和前列腺素 E2 的 IC50值分别为 371 和 126 μM。
TN1553	Deacetyl ganoderic acid F	Others	Others
	Deacetyl ganoderic acid F (DeGA F) 是从灵芝 Ganoderma lucidum 中提取的三萜类化合物，在体外和体内对脂多糖（LPS）诱导的炎症有抑制作用。
T6S2023	Harpagoside	Others; COX; NO Synthase	Immunology/Inflammation; Neuroscience; Others
	Harpagoside 是从爪钩草中分离出来的一种天然产物，可抑制COX-1和COX-2活性，并抑制 NO 的产生。
T5660	Menthone	IL Receptor; TNF; NF-κB; Parasite	Apoptosis; Immunology/Inflammation; Microbiology/Virology; NF-κB
	Menthone 是一种从植物和薄荷油中提取的单萜，是精油的主要挥发性成分，具有抗炎和抗氧化特性。
T2916	Patchouli alcohol 百秋李醇,Patchouli camphor,Patchoulol,(-)-Patchouli Alcohol,广藿香醇	Antibacterial; Antifungal	Microbiology/Virology
	Patchouli alcohol (Patchoulol) 是一种从广藿香中提取的天然三环倍半萜，有抗幽门螺杆菌和抗炎活性。
TN2091	Polygalacin D	Apoptosis; IAP	Apoptosis
	Polygalacin D 是从桔梗中分离的一种天然产物，具有抗癌和抗增殖特性。它通过 PI3K/Akt 途径诱导凋亡。它抑制 IAP 蛋白家族的表达，并通过抑制 GSK3β，Akt 的磷酸化和 PI3K 的表达来阻断 PI3K/Akt 途径。
T2S0731	Trilobatin 三叶苷,三叶甙,P-Phlorizin	Amylase	Metabolism
	Trilobatin (P-Phlorizin) 是源自Lithocarpus polystachyusRehd 的甜味剂，是一种HIV-1抑制剂，靶向 Gp41 包膜蛋白，具有神经保护作用。它还是SGLT1/2抑制剂，可选择性诱导人肝母细胞瘤细胞增殖。
T3676	Sesamol 1,3-Benzodioxol-5-ol,3,4-Methylenedioxyphenol,芝麻酚	Apoptosis; AMPK	Apoptosis; Chromatin/Epigenetic; PI3K/Akt/mTOR signaling
	Sesamol (1,3-Benzodioxol-5-ol) 是芝麻油的主要成分，具有抗氧化和抗肿瘤活性。它是一种自由基清除剂，在 DPPH 实验中，IC50为 5.95±0.56 μg/mL。
T5S0581	Sec-O-Glucosylhamaudol 亥茅酚苷,Hamaudol 3-glucoside	Others; Opioid Receptor	Endocrinology/Hormones; GPCR/G Protein; Neuroscience; Others
	Sec-O-Glucosylhamaudol (Hamaudol 3-glucoside) 是从滨海前胡中分离得到的一种天然产物，能够降低 μ 阿片受体的蛋白水平，可用于缓解疼痛的研究。它通过调节脂多糖刺激的 RAW264.7 细胞系中的 p38 丝裂原活化蛋白激酶具有抗炎作用。
T2S2362	Dehydrocorydaline nitrate 去氢延胡索甲素硝酸盐,硝酸脱氢紫堇碱	BCL; Others; PARP; p38 MAPK; Caspase; Parasite; Autophagy	Apoptosis; Autophagy; Chromatin/Epigenetic; DNA Damage/DNA Repair; MAPK; Microbiology/Virology; Others; Proteases/Proteasome
	Dehydrocorydaline nitrate 是生物碱。Dehydrocorydaline 调节 Bax，Bcl-2蛋白表达，激活 caspase-7，caspase-8，并使 PARP 失活。它能增强 p38 MAPK 活化，具有抗炎、抗癌、抗疟疾等功效。
T7033	Rosmanol	Antioxidant; COX	Immunology/Inflammation; Neuroscience; oxidation-reduction
	Rosmanol 能够显著抑制脂多糖诱导的 INOS、COX-2 的表达，抑制低密度脂蛋白的氧化，并具有抗炎作用。
T5S2283	Sesamolin	p38 MAPK; Caspase; JNK	Apoptosis; MAPK; Proteases/Proteasome
	Sesaminol 是从Justicia orbiculata 中分离得到的一种天然产物，抑制脂质过氧化，具有神经保护作用和抗氧化活性。它通过抑制JNK、p38 MAPKs 和caspase-3磷酸化，抑制MAPK 的级联反应。
TJS1779	Protosappanin A 原苏木素A,PTA	NADPH-oxidase; IL Receptor; IκB/IKK; TNF; NF-κB; TLR; ROS; COX; HIV Protease; JAK; NO Synthase; STAT	Angiogenesis; Apoptosis; Chromatin/Epigenetic; Immunology/Inflammation; JAK/STAT signaling; Microbiology/Virology; Neuroscience; NF-κB; Proteases/Proteasome; Stem Cells
	Protosappanin A (PTA) 是从苏木中分离得到的免疫抑制成分和主要联苯化合物，通过下调 JAK2和 STAT3的磷酸化，抑制 JAK2/STAT3依赖的炎症通路。
T4S0878	Prunetin 樱黄素,Prunusetin	ERK; Dehydrogenase; NF-κB	MAPK; Metabolism; NF-κB
	Prunetin (Prunusetin) 是一种O-甲基化异黄酮，具有抗炎的作用。它是人醛脱氢酶的有效抑制剂。
TN2063	Physalin B NSC-287088	Apoptosis; NF-κB; Akt; PI3K; Nrf2; NOD	Apoptosis; Cytoskeletal Signaling; Immunology/Inflammation; NF-κB; PI3K/Akt/mTOR signaling
	Physalin B 是茄科植物的主要活性化合物之一，具有广泛的生物活性，可用于治疗炎症湿疹和疱疹等疾病。Physalin B 通过激活 PI3K/Akt 通路抑制 NF-κB 和 NLRP3，从而改善脂多糖诱导的急性肺损伤造成的炎症反应。Physalin B 通过激活 Nrf2 通路抑制 PDGF-BB 诱导的 VSMC 增殖、迁移和表型转化。Physalin B 通过抑制 LAP2α-HDAC1 介导的胶质瘤相关癌基因 1 的去乙酰化和肝星状细胞活化来发挥抗肿瘤活性。
T4479	Isomaculosidine	Others	Others
	Isomaculosidine can significantly inhibit nitric oxide (NO) production in lipopolysaccharide (LPS)-stimulated BV2 cells.
TN3635	Chlojaponilactone B	IL Receptor; IκB/IKK; TNF; NOS; NF-κB	Apoptosis; Immunology/Inflammation; NF-κB
	Chlojaponilactone B has anti-inflammatory activity, it exhibits pronounced inhibition of nitric oxide (NO) production in lipopolysaccharide (LPS)-induced RAW 264.7 macrophages.
TN4726	Oxyphyllenone A	Others	Others
	Oxyphyllenone A can inhibit the NO production in lipopolysaccharide-activated macrophages.
TN3519	Bisdehydroneotuberostemonine	Others	Others
	Bisdehydroneotuberostemonine shows significant inhibitory effect on lipopolysaccharide-induced nitric oxide production in BV2 microglia at 100 uM.
TN4409	Lansiumarin C	TNF	Apoptosis
	Lansiumarin C can decrease nitric oxide (NO) and tumor necrosis factor-α (TNF-α) production in lipopolysaccharide (LPS)-induced macrophages.
TN4633	Neocryptotanshinone II	NOS; NF-κB	Immunology/Inflammation; NF-κB
	Neocryptotanshinone inhibits lipopolysaccharide-induced inflammation in RAW264.7 macrophages by suppression of NF-ÎºB and iNOS signaling pathways.
TN4827	Preskimmianine	Others	Others
	Preskimmianine is the biogenetic precursor of skimmianine.It can significantly inhibit nitric oxide (NO) production in lipopolysaccharide (LPS)-stimulated BV2 cells.
TN4941	Sanggenon N	Others	Others
	Sanggenon N shows protective effects on t-BHP-induced oxidative stress with the EC50 value of 23.45 ± 4.72 uM. It inhibits lipopolysaccharide-induced nitric oxide production in RAW 264.7 macrophages.
TN4938	Samidin	p38 MAPK; TNF; NF-κB; COX; DNA/RNA Synthesis; JNK	Apoptosis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Immunology/Inflammation; MAPK; Neuroscience; NF-κB
	Samidin has anti-inflammatory properties through suppression of NF-ÎºB and AP-1-mediated-genes in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells.
TN2153	Rhaponticin 6′′-O-gallate 土大黄苷 6''-O-没食子酸酯,Rhaponticin 6''-O-gallate	Others	Others
	Rhaponticin 6''-O-gallate showed inhibitory activity of NO production in lipopolysaccharide-activated macrophages, (IC50 = 11-69 microM).
TN2152	Rhaponticin 2′′-O-gallate 土大黄苷 2''-O-没食子酸酯,Rhaponticin 2''-O-gallate	Others	Others
	Rhaponticin 2''-O-gallate showed inhibitory activity of NO production in lipopolysaccharide-activated macrophages, (IC50 = 11-69 microM).
T82211	Herpotrichone B
	Herpotrichone B exhibits potent anti-neuroinflammatory activity in BV-2 microglial cells induced by lipopolysaccharide (LPS), with a half-maximal inhibitory concentration (IC50) of 0.11μM.
T5768	bruceine B	TNF; Parasite	Apoptosis; Microbiology/Virology
	Bruceine B 是一种有效的白细胞-内皮细胞粘附抑制剂，可抑制蛋白质和核酸合成。
TN3241	7-O-Acetylbonducellpin C	Others	Others
	7-O-Acetylbonducellpin C may exhibit significant inhibition of nitric oxide production of RAW264.7 macrophages stimulated by lipopolysaccharide (LPS).
TN5202	Undulatoside A	Others	Others
	Undulatoside A has anti-inflammatory activity, it exhibits inhibition on nitric oxide production in lipopolysaccharide induced RAW 264.7 macrophages with the IC50 value of 49.8 uM.
TN5247	Vogeloside	Others	Others
	Vogeloside shows inhibition of nitric oxide production in lipopolysaccharide-activated macrophages; its activity is comparable to that of aminoguanidine, a classic inhibitor.
T83056	Anti-inflammatory agent 5
	5 是一种抗炎剂，对由 LPS 诱导的 BV-2 小胶质细胞中 NO 的生成显示出显著的抑制活性。
TN4182	Hannokinol	Others	Others
	(+)-Hannokinol and MESO-hannokinol can significantly inhibit lipopolysaccharide-induced nitric oxide production in BV2 microglial cells at concentrations ranging from 1 microM to 100 microM.
T80860	Vitisin B (-)-Vitisin B,E-Vitisin B
	Vitisin B，从Vitis thunbergii var. taiwaniana分离提取，对脂多糖（LPS）诱导的关节炎表现出抗炎活性。
T3P2855	Chamigrenal	EGFR; NOS; PAFR; COX; Prostaglandin Receptor	Angiogenesis; GPCR/G Protein; Immunology/Inflammation; JAK/STAT signaling; Neuroscience; Tyrosine Kinase/Adaptors
	β-Chamigrenal has anti-inflammatory activity, it has inhibitory effects on lipopolysaccharide-induced nitric oxide and prostaglandin E2 production in RAW 264.7 macrophages. Chamigrenal shows platelet-activating factor antagonistic activity and the IC(50)
TN4050	Fargesone A	NOS	Immunology/Inflammation
	Fargesone A shows inhibitory effects on nitric oxide (NO) production in the lipopolysaccharide plus interferon-gamma activated-murine macrophage cell line, J774.1.
T72858	Maydispenoid B	Others	Others
	Maydispenoid B，一种有效的免疫抑制剂，能够抑制抗CD3/抗CD28单抗和脂多糖激活的小鼠脾细胞增殖。
T82212	Herpotrichone A
	Herpotrichone A在LPS诱导的BV-2小胶质细胞中表现出显著的抗炎活性，IC50值为0.41μM。
TN4089	Futokadsurin C	Others	Others
	Futokadsurin C can inhibit nitric oxide production by a murine macrophage-like cell line (RAW 264.7), which is activated by lipopolysaccharide and interferon-gamma.
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天然产物

Lipopolysaccharides, Escherichiacoli

Cat.No: T41078

Synonym: Lipopolysaccharide, E. coli O111:B4

Target: Others

7,3',4'-Tri-O-methylluteolin

Cat.No: TN1291

Synonym: 5-Hydroxy-3',4',7-trimethoxyflavone,木犀草素-7,3',4'-三甲醚

Target: TNF, COX, Interleukin

Lipopolysaccharides

Cat.No: T11855

Synonym: 脂多糖,LPS

Target: Others

Secologanic acid

Cat.No: TN1021

Target: NO Synthase

N-Methylnuciferine

Cat.No: TWS0704

Target: Others

Cat.No: TN1933

Synonym: 帽柱木菲碱,帽柱叶碱

Target: IL Receptor, TNF, NF-κB

2-Hydroxydecanoic acid

Cat.No: T29352

Synonym: (±)-α-hydroxy Decanoic Acid,羟基癸酸,(±)-2-hydroxy Decanoic Acid,alpha-Hydroxydecanoic acid,2-hydroxy Decylic Acid,2-Hydroxydecanoate

Target: Others

Cat.No: TN2167

Target: Reactive Oxygen Species, NO Synthase

Euphorbia Factor L2

Cat.No: T5798

Synonym: 千金子素L2,euphorbiafactor L2,大戟因子L2

Target: Apoptosis, NF-κB

Cat.No: T3383

Synonym: 升麻素,Cimitin

Target: Others

Octahydrocurcumin

Cat.No: T3S1692

Target: Anti-infection, NF-κB, Reactive Oxygen Species, ROS

p-Hydroxycinnamic acid

Cat.No: T7053

Synonym: p-Coumaric acid,p-Cumaric acid,p-Hydroxy-cinnamic acid,对羟基肉桂酸,NSC 59260

Target: Thrombin, Endogenous Metabolite, Prostaglandin Receptor

Deacetyl ganoderic acid F

Cat.No: TN1553

Target: Others

Cat.No: T6S2023

Target: Others, COX, NO Synthase

Cat.No: T5660

Target: IL Receptor, TNF, NF-κB, Parasite

Patchouli alcohol

Cat.No: T2916

Synonym: 百秋李醇,Patchouli camphor,Patchoulol,(-)-Patchouli Alcohol,广藿香醇

Target: Antibacterial, Antifungal

Cat.No: TN2091

Target: Apoptosis, IAP

Cat.No: T2S0731

Synonym: 三叶苷,三叶甙,P-Phlorizin

Target: Amylase

Cat.No: T3676

Synonym: 1,3-Benzodioxol-5-ol,3,4-Methylenedioxyphenol,芝麻酚

Target: Apoptosis, AMPK

Sec-O-Glucosylhamaudol

Cat.No: T5S0581

Synonym: 亥茅酚苷,Hamaudol 3-glucoside

Target: Others, Opioid Receptor

Dehydrocorydaline nitrate

Cat.No: T2S2362

Synonym: 去氢延胡索甲素硝酸盐,硝酸脱氢紫堇碱

Target: BCL, Others, PARP, p38 MAPK, Caspase, Parasite, Autophagy

Cat.No: T7033

Target: Antioxidant, COX

Cat.No: T5S2283

Target: p38 MAPK, Caspase, JNK

Protosappanin A

Cat.No: TJS1779

Synonym: 原苏木素A,PTA

Target: NADPH-oxidase, IL Receptor, IκB/IKK, TNF, NF-κB, TLR, ROS, COX, HIV Protease, JAK, NO Synthase, STAT

Cat.No: T4S0878

Synonym: 樱黄素,Prunusetin

Target: ERK, Dehydrogenase, NF-κB

Cat.No: TN2063

Synonym: NSC-287088

Target: Apoptosis, NF-κB, Akt, PI3K, Nrf2, NOD

Isomaculosidine

Cat.No: T4479

Target: Others

Chlojaponilactone B

Cat.No: TN3635

Target: IL Receptor, IκB/IKK, TNF, NOS, NF-κB

Oxyphyllenone A

Cat.No: TN4726

Target: Others

Bisdehydroneotuberostemonine

Cat.No: TN3519

Target: Others

Cat.No: TN4409

Target: TNF

Neocryptotanshinone II

Cat.No: TN4633

Target: NOS, NF-κB

Cat.No: TN4827

Target: Others

Cat.No: TN4941

Target: Others

Cat.No: TN4938

Target: p38 MAPK, TNF, NF-κB, COX, DNA/RNA Synthesis, JNK

Rhaponticin 6′′-O-gallate

Cat.No: TN2153

Synonym: 土大黄苷 6''-O-没食子酸酯,Rhaponticin 6''-O-gallate

Target: Others

Rhaponticin 2′′-O-gallate

Cat.No: TN2152

Synonym: 土大黄苷 2''-O-没食子酸酯,Rhaponticin 2''-O-gallate

Target: Others

Herpotrichone B

Cat.No: T82211

Cat.No: T5768

Target: TNF, Parasite

7-O-Acetylbonducellpin C

Cat.No: TN3241

Target: Others

Cat.No: TN5202

Target: Others

Cat.No: TN5247

Target: Others

Anti-inflammatory agent 5

Cat.No: T83056

Cat.No: TN4182

Target: Others

Cat.No: T80860

Synonym: (-)-Vitisin B,E-Vitisin B

Cat.No: T3P2855

Target: EGFR, NOS, PAFR, COX, Prostaglandin Receptor

Cat.No: TN4050

Target: NOS

Cat.No: T72858

Target: Others

Herpotrichone A

Cat.No: T82212

Cat.No: TN4089

Target: Others

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Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-02204	LBP Protein, Human, Recombinant (His) BPIFD2,lipopolysaccharide binding protein	Human	HEK293 Cells
	Lipopolysaccharide binding protein ( LBP ) is a glycoprotein that is synthesized principally by hepatocytes. LBP is a trace plasma protein that binds to the lipid A moiety of bacterial lipopolysaccharides ( LPSs ). LBP binds directly to the outer membrane of Gram-negative bacteria and purified aggregates of extracted endotoxin and catalyzes the delivery of endotoxin to the membrane ( mCD14, GPI-Linked ) and soluble ( sCD14 ) forms of CD14, thereby markedly increasing host cell sensitivity to end...
TMPH-00648	LapB Protein, E. coli, Recombinant (His) Lipopolysaccharide assembly protein B,lapB,Lipo...	E. coli	E. coli
	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane.
TMPH-00649	LptA Protein, E. coli, Recombinant (His & SUMO) lptA,Lipopolysaccharide export system protein LptA	E. coli	E. coli
	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm.
TMPH-01429	HSP90AA1 Protein, Human, Recombinant (His) Lipopolysaccharide-associated protein 2,Heat shock ...	Human	E. coli
	HSP90AA1 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 36.0 kDa and the accession number is P07900.
TMPH-01427	HSPA8 Protein, Human, Recombinant (His) Lipopolysaccharide-associated protein 1,HSPA8,Heat ...	Human	P. pastoris (Yeast)
	HSPA8 Protein, Human, Recombinant (His) is expressed in Yeast.
TMPJ-00966	GDF-5 Protein, Human, Recombinant Lipopolysaccharide-associated protein 4,Cartilage-d...	Human	E. coli
	Growth Differentiation Factor 5(GDF-5, BMP-14) is a member of the BMP family of TGFβ superfamily proteins. Human GDF-5, -6, and -7 are a defined subgroup of the BMP family. GDF-5 is synthesized as a homodimeric precursor protein consisting of a 354 amino acid (aa) Nterminal proregion and a 120 aa C-terminal mature peptide. Mature human GDF-5 shares 99% aa sequence identity with both mature mouse and rat GDF-5. GDF-5 signaling is mediated by formation of a heterodimeric complex consisting of a ty...
TMPY-02904	TLR4 Protein, Human, Recombinant (His) TLR-4,TOLL,toll-like receptor 4,ARMD10,TLR4,CD284	Human	Baculovirus Insect Cells
	TLR4, also known as TLR-4, is a member of the Toll-like receptor (TLR) family, which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. TLR4 is most abundantly expressed...
TMPH-03048	LpxA Protein, MenC, Recombinant (His) lpxA,Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-...	MenB	E. coli
	Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
TMPH-00650	LptE Protein, E. coli, Recombinant (His & Myc) LPS-assembly lipoprotein LptE,lptE	E. coli	E. coli
	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane.
TMPH-00318	LpxD Protein, Burkholderia pseudomallei, Recombinant (His & Myc) lpxD,UDP-3-O-acylglucosamine N-acyltransferase	Burkholderia pseudomallei	E. coli
	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. LpxD Protein, Burkholderia pseudomallei, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 44.2 kDa and the accession number is A3NAT7.
TMPK-01242	MD2/LY96 Protein, Human, Recombinant (His) MD-2,Ly-96,ESOP-1,Lymphocyte antigen 96,LY96,ESOP1	Human	E. coli
	MD2, a 160-residue accessory glycoprotein, is responsible for the recognition and binding of Gram-negative bacterial membrane component, lipopolysaccharide (LPS).Internalization of pathogen inside the mononuclear phagocytes has also been attributed to MD2 which leads to the clearance of pathogens from the host. MD2/LY96 Protein, Human, Recombinant (His) is expressed in E. coli expression system with C-His tag. The predicted molecular weight is 18.07 kDa and the accession number is Q9Y6Y9-1.
TMPH-03069	CSL3 Protein, Oncorhynchus keta, Recombinant (His) L-rhamnose-binding lectin CSL3	Oncorhynchus keta	E. coli
	L-rhamnose binding lectin. Has hemagglutinating activity towards rabbit erythrocytes, human type A erythrocytes, human type B erythrocytes, human type O erythrocytes and sheep erythrocytes. Hemagglutinating activity is inhibited by smooth-type lipopolysaccharide (LPS) from S.flexneri 1A, A.salmonicida and E.coli K12, but not by rough-type LPS from S.flexneri, E.coli K12 and E.coli EH100. Agglutinates E.coli K12 and B.subtilis.
TMPK-00632	MD2/LY96 Protein, Cynomolgus, Recombinant (His) ESOP-1,LY96,Lymphocyte antigen 96,ESOP1,MD-2	Cynomolgus	E. coli
	MD2, a 160-residue accessory glycoprotein, is responsible for the recognition and binding of Gram-negative bacterial membrane component, lipopolysaccharide (LPS).Internalization of pathogen inside the mononuclear phagocytes has also been attributed to MD2 which leads to the clearance of pathogens from the host. MD2/LY96 Protein, Cynomolgus, Recombinant (His) is expressed in E. coli expression system with C-His tag. The predicted molecular weight is 17.97 kDa and the accession number is B3Y6B0.
TMPK-00767	SLPI Protein, Human, Recombinant (hFc) WFDC4,HUSI,SLPI,WAP4,MPI,BLPI,ALK1,HUSI-1,ALP	Human	HEK293 Cells
	Elafin and SLPI (secretory leucocyte protease inhibitor) have multiple important roles both in normal homoeostasis and at sites of inflammation. These include antiprotease and antimicrobial activity as well as modulation of the response to LPS (lipopolysaccharide) stimulation. Elafin and SLPI are members of larger families of proteins secreted predominantly at mucosal sites, and have been shown to be modulated in multiple pathological conditions. SLPI Protein, Human, Recombinant (hFc) is express...
TMPJ-00574	RNASE3 Protein, Human, Recombinant (His) RNase 3,RNS3,ECP,Eosinophil Cationic Protein,RNASE3,Ribonucl...	Human	HEK293 Cells
	Ribonuclease 3 (RNASE3) is a basic protein that is localized to the eosinophil primary matrix and belongs to the pancreatic ribonuclease family. RNASE3 is released during degranulation of eosinophils. RNASE3 possesses a wide variety of biological activities. RNASE3 interacts with bacterial lipopolysaccharide (LPS) and lipoteichoic acid (LTA). RNASE3 exhibits antibacterial activity, including cytoplasmic membrane depolarization of preferentially Gram-negative, but also Gram-positive strains. It p...
TMPY-01909	Elafin Protein, Human, Recombinant (His) WAP3,ESI,peptidase inhibitor 3,SKALP,cementoin,MGC13613,WFDC...	Human	HEK293 Cells
	Elafin, also known as Elastase-specific inhibitor, Peptidase inhibitor 3, Protease inhibitor WAP3, Skin-derived antileukoproteinase, WAP four-disulfide core domain protein 14, PI3, WAP3 and WFDC14, is a secreted protein that contains one WAP domain. Elafin / PI3 consists of two domains: the transglutaminase substrate domain (cementoin moiety) and the elastase inhibitor domain. The transglutaminase substrate domain at the N-terminus serves as an anchor to localize elafin covalently to specific si...
TMPK-00924	SLPI Protein, Mouse, Recombinant (hFc) WAP4,BLPI,SLPI,HUSI-1,HUSI,MPI,ALP,WFDC4,ALK1	Mouse	HEK293 Cells
	Elafin and SLPI (secretory leucocyte protease inhibitor) have multiple important roles both in normal homoeostasis and at sites of inflammation. These include antiprotease and antimicrobial activity as well as modulation of the response to LPS (lipopolysaccharide) stimulation. Elafin and SLPI are members of larger families of proteins secreted predominantly at mucosal sites, and have been shown to be modulated in multiple pathological conditions. SLPI Protein, Mouse, Recombinant (hFc) is express...
TMPJ-00158	Apolipoprotein A-I/APOA1 Protein, Human, Recombinant Apolipoprotein A-I,APOA1,Apo-AI,ApoA-I	Human	E. coli
	Apolipoprotein A1 (APOA1) is a secreted protein which belongs to the Apolipoprotein A1/A4/E family. APOA1 is the major protein component of high density lipoprotein (HDL) in plasma. APOA1 plays a critical role in various biological processes, such as Cholesterol metabolism, Lipid metabolism and transport, Steroid metabolism. APOA1 promotes cholesterol efflux from tissues to the liver and thus helps to clear cholesterol from arteries. Defects in this gene resulted in HDL deficiencies, including T...
TMPY-02908	BPI Protein, Human, Recombinant (His) BPIFD1,bactericidal/permeability-increasing protein,rBPI	Human	HEK293 Cells
	Bactericidal/permeability-increasing protein is a member of the BPI/LBP/Plunc superfamily and BPI/LBP family. It is a cationic protein which can be detected in the azurophilic granule and on the surface of polymorphonuclear leukocytes. Bactericidal/permeability-increasing protein also is a lipopolysaccharide binding protein. It is associated with human neutrophil granules and has bactericidal activity on gram-negative organisms. Bactericidal/permeability-increasing protein contains two domains t...
TMPY-03999	MD2/LY96 Protein, Mouse, Recombinant (hFc) lymphocyte antigen 96,ESOP-1,MD2,MD-2	Mouse	HEK293 Cells
	LY96 (Lymphocyte Antigen 96, also known as ESOP-1) is a Protein Coding gene. 2 alternatively spliced human isoforms have been reported. This gene encodes a protein that associates with toll-like receptor 4 on the cell surface and confers responsiveness to lipopolysaccharide (LPS), thus providing a link between the receptor and LPS signaling. LY-96 also cooperates with TLR2 in the response to cell wall components from Gram-positive and Gram-negative bacteria. It enhances the TLR4-dependent activa...
TMPJ-00534	hFcgR4 Protein, Mouse, Recombinant (His) Low Affinity Immunoglobulin γ Fc Region Receptor IV,FcgR4,Lo...	Mouse	HEK293 Cells
	Fcgr4, also known as CD16-2, is one of the receptors for Fc region of IgG which involve in immune responses. Fcgr4 mainly functions in cellular response to lipopolysaccharide, NK T cell proliferation, regulation of sensory perception of pain, wound healing etc. Three groups are included for Fc γ receptors (FcR), and they are Fc γ RI (CD64), Fc γ RII (CD32), and Fc γ RIII (CD16). Among these, CD64 possess high affinity even for monomeric IgG, while CD32 and CD16 display a relative lower affinity ...
TMPH-01621	BRCC3 Protein, Human, Recombinant (His & SUMO) BRCC36,CXorf53,C6.1A,BRCC3,BRCA1/BRCA2-containing complex su...	Human	E. coli
	Metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Does not have activity toward 'Lys-48'-linked polyubiquitin chains. Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). In the BRCA1-A complex, it specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX, anta...
TMPY-04260	p38 Protein, Human, Recombinant (His) mitogen-activated protein kinase 14,CSPB1,PRKM14,RK,p38α,CSB...	Human	Baculovirus Insect Cells
	MAPK14 contains 1 protein kinase domain and belongs to the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation, and development. MAPK14 can be detected in the brain, heart, placenta, pancreas, and skeletal muscle and it is expressed to a lesser extent in the lung, liver, and kidney. MAPK14 is activated by various environmental stresses ...
TMPY-04391	Lyn Protein, Human, Recombinant (GST) JTK8,LYN proto-oncogene, Src family tyrosine kinase,p56Lyn,p...	Human	Baculovirus Insect Cells
	Tyrosine-protein kinase Lyn is a member of the Src family of protein tyrosine kinases, which is mainly expressed in hematopoietic cells, in neural tissues liver, and adipose tissue. Tyrosine-protein kinase Lyn has many functions. Lyn kinase may downregulate the expression of stem cell growth factor receptor (KIT). Lyn kinase Acts as an effector of EpoR (erythropoietin receptor) in controlling KIT expression and may play a central role in erythroid differentiation during the switch between prolif...

重组蛋白

LBP Protein, Human, Recombinant (His)

Cat.No: TMPY-02204

Species: Human

Expression System: HEK293 Cells

LapB Protein, E. coli, Recombinant (His)

Cat.No: TMPH-00648

Species: E. coli

Expression System: E. coli

LptA Protein, E. coli, Recombinant (His & SUMO)

Cat.No: TMPH-00649

Species: E. coli

Expression System: E. coli

HSP90AA1 Protein, Human, Recombinant (His)

Cat.No: TMPH-01429

Species: Human

Expression System: E. coli

HSPA8 Protein, Human, Recombinant (His)

Cat.No: TMPH-01427

Species: Human

Expression System: P. pastoris (Yeast)

GDF-5 Protein, Human, Recombinant

Cat.No: TMPJ-00966

Species: Human

Expression System: E. coli

TLR4 Protein, Human, Recombinant (His)

Cat.No: TMPY-02904

Species: Human

Expression System: Baculovirus Insect Cells

LpxA Protein, MenC, Recombinant (His)

Cat.No: TMPH-03048

Species: MenB

Expression System: E. coli

LptE Protein, E. coli, Recombinant (His & Myc)

Cat.No: TMPH-00650

Species: E. coli

Expression System: E. coli

LpxD Protein, Burkholderia pseudomallei, Recombinant (His & Myc)

Cat.No: TMPH-00318

Species: Burkholderia pseudomallei

Expression System: E. coli

MD2/LY96 Protein, Human, Recombinant (His)

Cat.No: TMPK-01242

Species: Human

Expression System: E. coli

CSL3 Protein, Oncorhynchus keta, Recombinant (His)

Cat.No: TMPH-03069

Species: Oncorhynchus keta

Expression System: E. coli

MD2/LY96 Protein, Cynomolgus, Recombinant (His)

Cat.No: TMPK-00632

Species: Cynomolgus

Expression System: E. coli

SLPI Protein, Human, Recombinant (hFc)

Cat.No: TMPK-00767

Species: Human

Expression System: HEK293 Cells

RNASE3 Protein, Human, Recombinant (His)

Cat.No: TMPJ-00574

Species: Human

Expression System: HEK293 Cells

Elafin Protein, Human, Recombinant (His)

Cat.No: TMPY-01909

Species: Human

Expression System: HEK293 Cells

SLPI Protein, Mouse, Recombinant (hFc)

Cat.No: TMPK-00924

Species: Mouse

Expression System: HEK293 Cells

Apolipoprotein A-I/APOA1 Protein, Human, Recombinant

Cat.No: TMPJ-00158

Species: Human

Expression System: E. coli

BPI Protein, Human, Recombinant (His)

Cat.No: TMPY-02908

Species: Human

Expression System: HEK293 Cells

MD2/LY96 Protein, Mouse, Recombinant (hFc)

Cat.No: TMPY-03999

Species: Mouse

Expression System: HEK293 Cells

hFcgR4 Protein, Mouse, Recombinant (His)

Cat.No: TMPJ-00534

Species: Mouse

Expression System: HEK293 Cells

BRCC3 Protein, Human, Recombinant (His & SUMO)

Cat.No: TMPH-01621

Species: Human

Expression System: E. coli

p38 Protein, Human, Recombinant (His)

Cat.No: TMPY-04260

Species: Human

Expression System: Baculovirus Insect Cells

Lyn Protein, Human, Recombinant (GST)

Cat.No: TMPY-04391

Species: Human

Expression System: Baculovirus Insect Cells

Cat. No.	Product Name	Target	Signaling Pathways
T10350	Apremilast-d5 Apremilast D5,CC-10004 D5	TNF; PDE	Apoptosis; Metabolism
	Apremilast D5 (CC-10004 D5) is a deuterium-labeled Apremilast. Apremilast is an orally available inhibitor of PDE-4 (IC50: 74 nM). Apremilast inhibits TNF-α release by lipopolysaccharide (IC50: 104 nM).
TMIJ-0162	Dexamethasone-d4
	Dexamethasone-d4 是 Dexamethasone 的氘代化合物。Dexamethasone 的 CAS 号为 50-02-2。Dexamethasone是一种糖皮质激素受体激动剂和一种 IL 受体调节剂。在脂多糖诱导的巨噬细胞炎症反应中，它抑制含有炎性 microRNA-155 的外泌体的产生。

同位素标记化合物

Cat.No: T10350

Synonym: Apremilast D5,CC-10004 D5

Target: TNF, PDE

Dexamethasone-d4

Cat.No: TMIJ-0162

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