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Search Results for " gastric mucosa "

Targets Recommended: Others cholecystokinin

14

抑制剂 & 化合物

1

天然产物

1

化合物库

7

重组蛋白

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Cat. No.	Product Name
L6600	胃肠炎天然产物库		219 compounds
	219 种胃肠炎相关的生物活性小分子化合物的特有集合，用于高通量、高内涵筛选；

化合物库

胃肠炎天然产物库

Cat.No: L6600

Compounds: 219

Cat. No.	Product Name	Target	Signaling Pathways
T4579	Pentagastrin 五肽胃泌素,ICI-50123	Others; cholecystokinin	GPCR/G Protein; Others
	Pentagastrin (ICI-50123) 是一种选择性的胆囊收缩素 B(CCKB) 受体激动剂，IC50=11 nM。它能够增强胃粘膜对酸的防御机制，并保护胃粘膜免受损伤。
T24821	Spizofurone Espizofurona,AG-629	Others	Others
	Spizofurone (Espizofurona) 具有抗溃疡活性，对大鼠胃黏膜具有保护作用，可增加分离的牛蛙十二指肠粘膜中的碱性分泌。
T31675	Esaprazole C/63	Others	Others
	Esaprazole (C/63) 对人胃黏膜具有剂量依赖性的细胞保护作用。
T1562	Rebamipide Proamipide,OPC12759,瑞巴派特	Free radical scavengers; COX; Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience; oxidation-reduction
	Rebamipide (OPC12759) 是一种粘膜保护剂，可诱导COX-2表达，增加PGE2水平，并以 COX-2 依赖性方式增强胃粘膜防御。
T31958	Glycine-pentagastrin Glycine pentagastrin,Boc-gly-trp-met-asp-phe-NH2,Tbgtmap	Others	Others
	Glycine-pentagastrin can enhance gastric mucosal defence mechanisms against acid and protect the gastric mucosa from experimental injury.
T34087	Plaunotol Kelnac,Plaunotolum	Others	Others
	Plaunotol is a gastric protective agent that increases prostaglandins in the gastric mucosa and accelerates ulcer healing.
T15005	CP-66948	Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	CP-66948 是一种有效的 histamine H2 受体拮抗剂，对胃酸分泌有抑制作用，可用于保护胃黏膜和肠粘膜。
T39795	Tricarbonyldichlororuthenium(II) dimer CORM-2	Others	Others
	Tricarbonyldichlororuthenium(II) dimer, a pharmacological CO donor, prevents ischemia/reperfusion (I/R)-induced oxidative damage to the gastric mucosa by enhancing gastric blood flow (GBF) and reducing DNA oxidation and systemic inflammatory response.
T28335	PD 140376 PD-140376,PD140376	Others	Others
	PD 140376 is a highly selective antagonist radioligand for the cholecystokinin(B)-gastrin receptor in guinea pig gastric mucosa & cerebral cortex in the peripheral and central nervous systems.
TP1838	Xenin
	Xenin is a 25 amino acid peptide that has been identified in human gastric mucosa in the search for a counterpart to the amphibian octapeptide xenopsin.
T81074	Sucrose octasulfate sodium	Others	Others
	Sucrose octasulfate为硫糖铝组分，能直接刺激胃粘膜D细胞以促进生长抑素样免疫反应(SLI)的释放，进而发挥内源性胃生长抑素的溃疡愈合功能，适用于抗胃溃疡研究。
T71801	Arbaprostil	Others	Others
	Arbaprostil is a synthetic prostaglandin E analog that protects gastric mucosa, prevents ulceration, and promotes healing of peptic ulcers. The protective effect is independent of acid inhibition. It is also a potent inhibitor of pancreatic function and can inhibit the growth of experimental tumors. Arbaprostil is a prodrug for the potent PGE2.
T21939	ATB-337	Others	Others
	S-Diclofenac 的分子结构由 H2S 供体和非甾体类抗炎药双氯芬酸组合而成。S-Diclofenac 显著抑制前列腺素的合成，并且不会损伤胃粘膜。
T38045	Cholesterol β-D-Glucoside	Others	Others
	Cholesterol β-D-glucoside is a derivative of cholesterol that contains β-D-glucose . It is formed from cholesterol and glucosylceramide by β-glucosidase 1. It activates heat shock transcription factor 1 (Hsf1) in response to heat shock, which increases the expression of heat shock protein 70 (Hsp70) in TIG-3 human fetal lung fibroblasts when used at a concentration of 10 μM. Cholesterol β-D-glucoside (100 mg/kg) prevents ulcer formation following cold-restraint stress and increases Hsf1 activity...

化合物

Cat.No: T4579

Synonym: 五肽胃泌素,ICI-50123

Target: Others, cholecystokinin

Cat.No: T24821

Synonym: Espizofurona,AG-629

Target: Others

Cat.No: T31675

Synonym: C/63

Target: Others

Cat.No: T1562

Synonym: Proamipide,OPC12759,瑞巴派特

Target: Free radical scavengers, COX, Prostaglandin Receptor

Glycine-pentagastrin

Cat.No: T31958

Synonym: Glycine pentagastrin,Boc-gly-trp-met-asp-phe-NH2,Tbgtmap

Target: Others

Cat.No: T34087

Synonym: Kelnac,Plaunotolum

Target: Others

Cat.No: T15005

Target: Histamine Receptor

Tricarbonyldichlororuthenium(II) dimer

Cat.No: T39795

Synonym: CORM-2

Target: Others

Cat.No: T28335

Synonym: PD-140376,PD140376

Target: Others

Cat.No: TP1838

Sucrose octasulfate sodium

Cat.No: T81074

Target: Others

Cat.No: T71801

Target: Others

Cat.No: T21939

Target: Others

Cholesterol β-D-Glucoside

Cat.No: T38045

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
TN4489	Manassantin A	ERK; cAMP; TNF; NF-κB; MAPK; COX; HIF; Prostaglandin Receptor; JNK; STAT	Angiogenesis; Apoptosis; Chromatin/Epigenetic; GPCR/G Protein; Immunology/Inflammation; JAK/STAT signaling; MAPK; Neuroscience; NF-κB; Stem Cells
	Manassantin A is a high potent HIF-1 inhibitor, it protects the gastric mucosa from ethanol-induced acute gastric injury, and suggest that these protective effects might be associated with COX/PGE2 stimulation, inhibition of iNOS production and NF-ÎºB act

天然产物

Cat.No: TN4489

Target: ERK, cAMP, TNF, NF-κB, MAPK, COX, HIF, Prostaglandin Receptor, JNK, STAT

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPJ-01173	TFF3 Protein, Mouse, Recombinant (His) Itf,Trefoil factor 3,Intestinal trefoil factor,mITF,Tff3	Mouse	HEK293 Cells
	Trefoil factors (TFF) are secretory products of mucin producing cells. They play a key role in the maintenance of the surface integrity of oral mucosa and enhance healing of the gastrointestinal mucosa by a process called restitution. TFF comprises the gastric peptides (TFF1), spasmolytic peptide (TFF2), and the intestinal trefoil factor (TFF3). They have an important and necessary role in epithelial restitution within the gastrointestinal tract. Members of the trefoil family are characterized b...
TMPY-00519	Gastrokine 1 Protein, Human, Recombinant (His) UNQ489/PRO1005,CA11,foveolin,BRICD1,AMP18,gastrokine 1,FOV	Human	Baculovirus Insect Cells
	Gastrokine 1 (GKN1) belongs to the BRICHOS domain family and plays a major role in maintaining gastric mucosa integrity. GKN1 is highly expressed in gastric tissue and is secreted into the stomach but is not expressed in gastric cancer. GKN1-mediated inhibition of APP processing might represent a new approach for the prevention and therapy of Alzheimer's disease (AD). In the presence of GKN2, GKN1 loses its ability to decrease cell proliferation, induce apoptosis, and inhibit epigenetic alterati...
TMPJ-00265	Serpin F1 Protein, Mouse, Recombinant Pedf,Caspin,Stromal cell-derived factor 3,Sdf3,Pigment epith...	Mouse	E. coli
	Serpin F1 is secreted Neurotrophic protein and belongs to the serpin family. Serpin F1 Highly expressed in the liver, gastric glandular mucosa and renal tubules. It is also expressed in the brain, heart, lung retina and testes. It induces extensive neuronal differentiation in retinoblastoma cells. It is potent inhibitor of angiogenesis. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, exhibits no serine protease inhibitory activi...
TMPJ-01089	TFF1 Protein, Mouse, Recombinant (His) Bcei,Protein pS2,Ps2,Trefoil factor 1,Tff1	Mouse	HEK293 Cells
	Trefoil Factor 1 (TFF1) belongs to the three structurally related secreted proteins that contain trefoil domains.TFF1 is an approximately peptide that has an important effect in epithelial regeneration and wound healing.It originates from musculus and highly expressed by goblet cells of the gastric and intestinal mucosa and by conjunctival goblet cells. TFF1 is a copper-binding protein that can form disulfide-linked homodimers, associate into disulfide-linked complexes with Gastrokine 2, and fo...
TMPJ-00529	FABP6 Protein, Human, Recombinant (His) Ileal Lipid-Binding Protein,I-BABP,Intestinal Bile Acid-Bind...	Human	E. coli
	Fatty Acid-Binding Protein 6 (FABP6) is cytoplasmic protein that binds long-chain fatty acids and other hydrophobic ligands which belongs to the calycin superfamily. FABP6 expression is restricted in the small intestine to the ileum where it is involved in the enterohepatic circulation of bile acids. FABP6 forms a beta-barrel structure that accommodates the hydrophobic ligand in its interior. Isoform 2 is expressed in colorectal adenocarcinomas and their adjacent normal mucosa (at protein level)...
TMPJ-00385	CDH6 Protein, Human, Recombinant (hFc) K-Cadherin,Cadherin-6,CDH6,Kidney Cadherin	Human	HEK293 Cells
	Cadherin-6 (CDH6) is a type-II classic cadherin cell-cell adhesion molecules, which are expressed in graded or areal patterns, as well as layer-specific patterns, in the cortical plate. Human Cadherin-6 is synthesized as a 790 aa type I transmembrane glycoprotein that contains a 18 aa signal peptide, a 35 aa propeptide, a 562 aa extracellular region, a 21 aa transmembrane segment, and a 154 aa cytoplasmic domain. There are five cadherin domains of approximately 110 aa each in the extracellular r...
TMPY-02574	Chymase 1 Protein, Human, Recombinant (His) MCT1,chymase 1, mast cell,chymase,CYH	Human	Baculovirus Insect Cells
	The STR polymorphism in the CMA1 gene is associated with asthma and that this association is even stronger with atopic asthma. CMA1 and IL-4 in atopic asthma and for IL-4 in atopy in general. The local angiotensin II system (LAS) has numerous functions, including the regulation of growth and differentiation in the gastrointestinal tract. Angiotensin II (AngII) may be generated by angiotensin-I-converting enzyme (ACE) or mast cell chymase (CMA1) and plays an important role in inflammatory process...

重组蛋白

TFF3 Protein, Mouse, Recombinant (His)

Cat.No: TMPJ-01173

Species: Mouse

Expression System: HEK293 Cells

Gastrokine 1 Protein, Human, Recombinant (His)

Cat.No: TMPY-00519

Species: Human

Expression System: Baculovirus Insect Cells

Serpin F1 Protein, Mouse, Recombinant

Cat.No: TMPJ-00265

Species: Mouse

Expression System: E. coli

TFF1 Protein, Mouse, Recombinant (His)

Cat.No: TMPJ-01089

Species: Mouse

Expression System: HEK293 Cells

FABP6 Protein, Human, Recombinant (His)

Cat.No: TMPJ-00529

Species: Human

Expression System: E. coli

CDH6 Protein, Human, Recombinant (hFc)

Cat.No: TMPJ-00385

Species: Human

Expression System: HEK293 Cells

Chymase 1 Protein, Human, Recombinant (His)

Cat.No: TMPY-02574

Species: Human

Expression System: Baculovirus Insect Cells

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