gastric mucosa

Pentagastrin (ICI-50123) 是一种选择性的胆囊收缩素 B(CCKB) 受体激动剂，IC50=11 nM。它能够增强胃粘膜对酸的防御机制，并保护胃粘膜免受损伤。

CP-66948 是一种有效的 histamine H2 受体拮抗剂，对胃酸分泌有抑制作用，可用于保护胃黏膜和肠粘膜。

Spizofurone (Espizofurona) 具有抗溃疡活性，对大鼠胃黏膜具有保护作用，可增加分离的牛蛙十二指肠粘膜中的碱性分泌。

Rebamipide (OPC12759) 是一种粘膜保护剂，可诱导COX-2表达，增加PGE2水平，并以 COX-2 依赖性方式增强胃粘膜防御。

Esaprazole (C 63) 对人胃黏膜具有剂量依赖性的细胞保护作用。

Quinotolast (亦称FK021) 是一种口服活性的肥大细胞稳定剂，对胃粘膜具有细胞保护作用。它具有抗过敏和抗溃疡的功能。

S-Diclofenac 的分子结构由 H2S 供体和非甾体类抗炎药双氯芬酸组合而成。S-Diclofenac 显著抑制前列腺素的合成，并且不会损伤胃粘膜。

PD 140376 is a highly selective antagonist radioligand for the cholecystokinin(B)-gastrin receptor in guinea pig gastric mucosa & cerebral cortex in the peripheral and central nervous systems.

Glycine-pentagastrin can enhance gastric mucosal defence mechanisms against acid and protect the gastric mucosa from experimental injury.

Plaunotol is a gastric protective agent that increases prostaglandins in the gastric mucosa and accelerates ulcer healing.

Tricarbonyldichlororuthenium(II) dimer, a pharmacological CO donor, prevents ischemia reperfusion (I R)-induced oxidative damage to the gastric mucosa by enhancing gastric blood flow (GBF) and reducing DNA oxidation and systemic inflammatory response.

Arbaprostil is a synthetic prostaglandin E analog that protects gastric mucosa, prevents ulceration, and promotes healing of peptic ulcers. The protective effect is independent of acid inhibition. It is also a potent inhibitor of pancreatic function and can inhibit the growth of experimental tumors. Arbaprostil is a prodrug for the potent PGE2.

Sucrose octasulfate为硫糖铝组分，能直接刺激胃粘膜D细胞以促进生长抑素样免疫反应(SLI)的释放，进而发挥内源性胃生长抑素的溃疡愈合功能，适用于抗胃溃疡研究。

Rotraxate (TEI 5103) 是一种可口服的抗溃疡化合物，能够提高胃黏膜的血流量并增强其完整性。Rotraxate 被用于研究药物对胃黏膜的保护效应，尤其是在探讨化合物通过直接作用于胃黏膜来预防或治疗胃溃疡的机制方面。

Manassantin A is a high potent HIF-1 inhibitor, it protects the gastric mucosa from ethanol-induced acute gastric injury, and suggest that these protective effects might be associated with COX PGE2 stimulation, inhibition of iNOS production and NF-κB act

6-Gingediol (compound 13) 作为一种从生姜中提取的化合物,展示了潜在的抗血清素效果和对胃粘膜的保护能力.在浓度不超过 10 μM 的情况下,该化合物不具备刺激性气味;然而,其浓度一旦超过 100 μM,乃至达到 1000 μM,刺激性气味则变得非常明显.

Xenin is a 25 amino acid peptide that has been identified in human gastric mucosa in the search for a counterpart to the amphibian octapeptide xenopsin.