carbapenem

Meropenem (SM 7338) 是一种具有广谱抗菌活性的碳青霉烯抗生素，对敏感和耐药的淋病奈瑟氏球菌，流感嗜血杆菌和杜克氏杆菌的 MIC 值分别为 0.02-0.06 mg mL，0.03-0.12 mg mL 和 0.015-0.12 mg mL。

Meropenem trihydrate (SM 7338 trihydrate) 是一种碳青霉烯抗生素，具有广谱抗菌活性。它对敏感和耐药的杜克氏杆菌 (MIC 值为 0.015-0.12 mg mL)， 淋病奈瑟氏球菌 (MIC 值为 0.02-0.06 mg mL)和流感嗜血杆菌 (MIC 值为 0.03-0.12 mg mL) 具有活性。

Lenapenem is a broad-spectrum, carbapenem antibiotic with bactericidal activity by weakens the bacterial cell wall and leads to lytic cell death.

Ceftolozane sulfate (FR-264205) 是一种头孢菌素类抗生素，具有广谱的抗菌活性，抑制 P. aeruginosa PAO1,抑制假单胞菌，可用于研究肺炎。

Vaborbactam ammonium salt 是一种 β-内酰胺酶抑制剂，可以恢复碳青霉烯类药物对 KPC 生产菌株的活性，常与其它药物连用来研究真菌感染。

Imipenem monohydrate (Imipenem) 是从微生物 Streptomyces cattleya 分离得到的碳青霉烯类抗生素，是一种 β 内酰胺类抗生素。Imipenem monohydrate 作用于细菌细胞壁，能广泛有效抑制多种革兰氏阳性和阴性菌。

Imipenem (MK0787) 是一种噻吩霉素衍生物，属于抗生素类，具有抗菌活性，对革兰氏阳性和革兰氏阴性菌具有部分的抑制作用。Imipenem 可用于研究碳青霉烯类非易感性感染和铜绿假单胞菌生物膜感染。

Tebipenem 是一种口服碳青霉烯类抗生素。 它对革兰氏阳性和阴性细菌具有广谱活性。

Meropenem (SM 7338) sodium 是一种碳青霉烯类抗生素，具有广泛的抗微生物活性。该化合物对于敏感及耐药性强的淋病奈瑟氏球菌 (MIC 0.02-0.06 mg mL)、流感嗜血杆菌 (MIC 0.03-0.12 mg mL) 及杜克氏杆菌 (MIC 0.015-0.12 mg mL) 均显示出显著的抑制效果。

Ertapenem is a parenteral carbapenem. It has a broad spectrum of antimicrobial activity. It is highly resistant to inactivation by a wide variety of beta-lactamases.

Benapenem是一种具有广谱抗菌活性的碳青霉烯类(β-内酰胺)化合物。目前，Benapenem已被用于临床评估，作为治疗尿路感染的静脉内治疗方案。

LYS228（亦称为Ancremonam）是一种针对碳青霉烯耐药肠杆菌科细菌（MIC90 = 2 uM mL）有效的抗生素。在所有类别的β-内酰胺酶存在下，它仍表现出对碳青霉烯耐药肠杆菌科分离株（CRE）的显著抗菌作用。

KPC-IN-1 (compound 1e) 是一种针对肺炎克雷伯氏菌碳青霉烯酶KPC-2的抑制剂 (IC50=8.3 nM)。KPC 属于革兰氏阴性菌中表达的 β-内酰胺酶，可以水解碳青霉烯，导致细菌对Carbapenem类抗生素表现出显著耐药性。

Panipenem is a carbapenem antibiotic used in combination with betamipron.

Doripenem 是对革兰氏阳性菌、阴性菌和厌氧菌有效的β-内酰胺广谱抗生素。

DA 1131 is a new carbapenem antibiotic. It undergoes renal metabolism by renal dehydropeptidase I.

LYS228 is a potent antibiotics against Carbapenem-Resistant Enterobacteriaceae (MIC90 = 2 uM mL). LYS228 is potent in the presence of all classes of beta-lactamases.

Cp-5484 is a new kind of Quaternary carbapenem with strong anti MRSA activity and low acute toxicity.

CS 834, a novel oral carbapenem antibiotic, is an ester prodrug of the active metabolite R-95867.

LK 157 is a tricyclic carbapenem with potent activity against class A and class C beta-lactamases.

Razupenem ( SMP-601, PTZ601) is a broad-spectrum injectable antibiotic derived from the carbapenem subgroup of β-lactam antibiotics. It has been developed as an alternative drug against bacteria that have developed antibiotic resistance to commonly used a

N-3-oxo-pentanoyl-L-Homoserine lactone is a chain-shortened derivative of the bacterial quorum sensing signaling molecule N-3-oxo-octanoyl-L-homoserine lactone .1It inhibits binding of the autoinducer N-3-oxo-hexanoyl homoserine lactone toE. colicontaining the transcription factor LuxR when used at a concentration of 230 nM.2It acts as an autoinducer to activate theV. fischeriluminescence system inE. coliwhen used at concentrations ranging from 20 to 200 nM. 1.Chhabra, S.R., Stead, P., Bainton, N.J., et al.Autoregulation of carbapenem biosynthesis in Erwinia carotovora by analogues of N-(3-oxohexanoyl)-L-homoserine lactoneJ. Antibiot. (Tokyo)46(3)441-454(1993) 2.Schaefer, A.L., Hanzelka, B.L., Eberhard, A., et al.Quorum sensing in Vibrio fischeri: Probing autoinducer-LuxR interactions with autoinducer analogsJ. Bacteriol.178(10)2897-2901(1996)

Acetyl-L-homoserine lactone belongs to the family of N-acylated homoserine lactones (HSLs) and has an acyl chain length of two carbons. HSLs perform a role in quorum sensing; however, unlike other HSLs, acetyl-L-homoserine lactone does not elicit a response in bacteria. In an assay of carbapenem antibiotic biosynthesis, acetyl-L-homoserine lactone does not induce a response in E. carotovora. In a fluorescence assay using E. coli containing a reporter plasmid of GFP expression in response to exogenous HSLs, acetyl-L-homoserine does not elicit GFP production.

TP0586352 is a potent inhibitor of LpxC, exhibiting efficacy against carbapenem-resistant strains of Klebsiella pneumoniae without inducing cardiovascular risks.