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Search Results for " carbapenem "

Targets Recommended: Others

26

抑制剂 & 化合物

2

天然产物

3

重组蛋白

2

同位素标记化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T27813	Lenapenem carbapenem	Others	Others
	Lenapenem is a broad-spectrum, carbapenem antibiotic with bactericidal activity by weakens the bacterial cell wall and leads to lytic cell death.
T12004	Meropenem trihydrate 美罗培南三水合物,SM 7338 trihydrate	Antibacterial; Antibiotic	Microbiology/Virology
	Meropenem trihydrate (SM 7338 trihydrate) 是一种碳青霉烯抗生素，具有广谱抗菌活性。它对敏感和耐药的杜克氏杆菌 (MIC 值为 0.015-0.12 mg/mL)，淋病奈瑟氏球菌 (MIC 值为 0.02-0.06 mg/mL)和流感嗜血杆菌 (MIC 值为 0.03-0.12 mg/mL) 具有活性。
T22314	Doripenem	Antibacterial; Antibiotic	Microbiology/Virology
	Doripenem 是对革兰氏阳性菌、阴性菌和厌氧菌有效的β-内酰胺广谱抗生素。
T17021	Tebipenem LJC 11036	Antibiotic	Microbiology/Virology
	Tebipenem 是一种口服碳青霉烯类抗生素。它对革兰氏阳性和阴性细菌具有广谱活性。
T9318	TP0586532	Others	Others
	TP0586532 是有效的non-hydroxamate LpxC 抑制剂 (IC50=0.101 μM)。TP0586532具有低心血管风险的特点，对肺炎克雷伯菌有效，包括耐药菌株。
T6231	Tebipenem Pivoxil ME1211,Orapenem,替比培南匹酯	Antibacterial; Antibiotic	Microbiology/Virology
	Tebipenem Pivoxil (Orapenem) 是一种碳青霉烯类新型口服抗生素。
T17210L	Vaborbactam ammonium salt RPX7009 ammonium salt,Vaborbactam ammonium salt（1360457-46-0 Free base）	Antibacterial	Microbiology/Virology
	Vaborbactam ammonium salt 是一种 β-内酰胺酶抑制剂，可以恢复碳青霉烯类药物对 KPC 生产菌株的活性，常与其它药物连用来研究真菌感染。
T4991	Ertapenem sodium 厄他培南钠,MK-826,L-749345,尔他培南钠	Antibacterial; Antibiotic	Microbiology/Virology
	Ertapenem sodium (MK-826) 是碳青霉烯，是一种 β-内酰胺抗生素，具有广谱抗菌活性。
T124492	Imipenem N-Formimidoyl thienamycin,MK0787	Antifungal	Microbiology/Virology
	Imipenem (MK0787) 是一种噻吩霉素衍生物，属于抗生素类，具有抗菌活性，对革兰氏阳性和革兰氏阴性菌具有部分的抑制作用。Imipenem 可用于研究碳青霉烯类非易感性感染和铜绿假单胞菌生物膜感染。
T23939	DA 1131 DA-1131,DA1131	Others	Others
	DA 1131 is a new carbapenem antibiotic. It undergoes renal metabolism by renal dehydropeptidase I.
T40088	TP0586352	Others	Others
	TP0586352 is a potent inhibitor of LpxC, exhibiting efficacy against carbapenem-resistant strains of Klebsiella pneumoniae without inducing cardiovascular risks.
T70429	TP-6076	Others	Others
	TP-6076 is a fluorocycline antibiotic, inhibiting bacterial protein synthesis, exhibiting great antimicrobial activity against carbapenem-resistant A. baumannii.
T20737	Panipenem CS-533,RS-533,RS533,CS533,CS 533,RS 533	Others	Others
	Panipenem is a carbapenem antibiotic used in combination with betamipron.
T31064	CP-5484 CP 5484,UNII-A53TMV6VUN,CP5484	Others	Others
	Cp-5484 is a new kind of Quaternary carbapenem with strong anti MRSA activity and low acute toxicity.
T31106	CS 834 UNII-H26S03B779,CS834,CS-834	Others	Others
	CS 834, a novel oral carbapenem antibiotic, is an ester prodrug of the active metabolite R-95867.
T32805	LK 157 LK-157,LK157	Others	Others
	LK 157 is a tricyclic carbapenem with potent activity against class A and class C beta-lactamases.
T70319	ANT431	Others	Others
	ANT431 is a novel metallo-β-lactamase inhibitor for the treatment of carbapenem-resistant enterobacteriaceae infections
T27962	Ancremonam LYS228,LYS-228,LYS 228	Others	Others
	LYS228 is a potent antibiotics against Carbapenem-Resistant Enterobacteriaceae (MIC90 = 2 uM/mL). LYS228 is potent in the presence of all classes of beta-lactamases.
T20107	Ertapenem Invanz,MK0826,MK-0826,MK 0826	Others	Others
	Ertapenem is a parenteral carbapenem. It has a broad spectrum of antimicrobial activity. It is highly resistant to inactivation by a wide variety of beta-lactamases.
T78987	SA09-Cu	Others	Others
	SA09-Cu是一种NDM-1的非竞争性抑制剂，具有9.6 nM的IC50。该化合物通过作用于氧化酶的Zn(II)-硫醇盐位点，能将NDM-1转化为无活性形态，从而抵御细菌细胞内的硫醇还原作用。SA09-Cu对于多种产生NDM-1的肠杆菌科碳青霉烯耐药菌株（CRE）表现出明显的抑制作用，有效恢复了美罗培南的活性，并有助于减缓碳青霉烯耐药性的进展。
T34270	Razupenem SMP601,SMP 601,PTZ601,PTZ 601,PTZ-601,SMP-601	Others	Others
	Razupenem ( SMP-601, PTZ601) is a broad-spectrum injectable antibiotic derived from the carbapenem subgroup of β-lactam antibiotics. It has been developed as an alternative drug against bacteria that have developed antibiotic resistance to commonly used a
T85015	N-(3-Oxobutanoyl)-L-homoserine lactone 3-oxo-C4-HSL	Others	Others
	N-(3-Oxobutanoyl)-L-homoserine lactone (3-oxo-C4-HSL) 是一种自调节因子，参与胡萝卜软腐欧文氏菌 ATCC 39048 中碳青霉烯类抗生素的生物合成。此外，它还能诱导 R. leguminosarum 中 rhiI 基因的表达。
T80372	P1
	P1是一种具有抗革兰氏阳性菌与抗革兰氏阴性菌能力的广谱抗菌肽，有效针对B. anthracis、耐碳青霉烯类细菌A. baumannii和K. pneumoniae。
T38300	Acetyl-L-Homoserine lactone	Others	Others
	Acetyl-L-homoserine lactone belongs to the family of N-acylated homoserine lactones (HSLs) and has an acyl chain length of two carbons. HSLs perform a role in quorum sensing; however, unlike other HSLs, acetyl-L-homoserine lactone does not elicit a response in bacteria. In an assay of carbapenem antibiotic biosynthesis, acetyl-L-homoserine lactone does not induce a response in E. carotovora. In a fluorescence assay using E. coli containing a reporter plasmid of GFP expression in response to exog...
T84433	Doripenem hydrate S 4661	Others	Others
	Doripenem is a broad-spectrum carbapenem antibiotic effective against both Gram-negative and Gram-positive bacteria, such as S. aureus, S. pneumoniae, E. coli, and K. pneumoniae, with minimum inhibitory concentrations (MICs) ranging from less than 0.015 to 0.3 µg/ml. It has been proven to reduce the viable bacteria count in mouse lung models of chronic P. aeruginosa respiratory tract infection at a dosage of 100 mg/kg per day. Doripenem operates by inhibiting bacterial cell wall synthesis throug...
T37338	N-3-oxo-pentanoyl-L-Homoserine lactone	Others	Others
	N-3-oxo-pentanoyl-L-Homoserine lactone is a chain-shortened derivative of the bacterial quorum sensing signaling molecule N-3-oxo-octanoyl-L-homoserine lactone .1It inhibits binding of the autoinducer N-3-oxo-hexanoyl homoserine lactone toE. colicontaining the transcription factor LuxR when used at a concentration of 230 nM.2It acts as an autoinducer to activate theV. fischeriluminescence system inE. coliwhen used at concentrations ranging from 20 to 200 nM. 1.Chhabra, S.R., Stead, P., Bainton, ...

化合物

Cat.No: T27813

Synonym: carbapenem

Target: Others

Meropenem trihydrate

Cat.No: T12004

Synonym: 美罗培南三水合物,SM 7338 trihydrate

Target: Antibacterial, Antibiotic

Cat.No: T22314

Target: Antibacterial, Antibiotic

Cat.No: T17021

Synonym: LJC 11036

Target: Antibiotic

Cat.No: T9318

Target: Others

Tebipenem Pivoxil

Cat.No: T6231

Synonym: ME1211,Orapenem,替比培南匹酯

Target: Antibacterial, Antibiotic

Vaborbactam ammonium salt

Cat.No: T17210L

Synonym: RPX7009 ammonium salt,Vaborbactam ammonium salt（1360457-46-0 Free base）

Target: Antibacterial

Ertapenem sodium

Cat.No: T4991

Synonym: 厄他培南钠,MK-826,L-749345,尔他培南钠

Target: Antibacterial, Antibiotic

Cat.No: T124492

Synonym: N-Formimidoyl thienamycin,MK0787

Target: Antifungal

Cat.No: T23939

Synonym: DA-1131,DA1131

Target: Others

Cat.No: T40088

Target: Others

Cat.No: T70429

Target: Others

Cat.No: T20737

Synonym: CS-533,RS-533,RS533,CS533,CS 533,RS 533

Target: Others

Cat.No: T31064

Synonym: CP 5484,UNII-A53TMV6VUN,CP5484

Target: Others

Cat.No: T31106

Synonym: UNII-H26S03B779,CS834,CS-834

Target: Others

Cat.No: T32805

Synonym: LK-157,LK157

Target: Others

Cat.No: T70319

Target: Others

Cat.No: T27962

Synonym: LYS228,LYS-228,LYS 228

Target: Others

Cat.No: T20107

Synonym: Invanz,MK0826,MK-0826,MK 0826

Target: Others

Cat.No: T78987

Target: Others

Cat.No: T34270

Synonym: SMP601,SMP 601,PTZ601,PTZ 601,PTZ-601,SMP-601

Target: Others

N-(3-Oxobutanoyl)-L-homoserine lactone

Cat.No: T85015

Synonym: 3-oxo-C4-HSL

Target: Others

Cat.No: T80372

Acetyl-L-Homoserine lactone

Cat.No: T38300

Target: Others

Doripenem hydrate

Cat.No: T84433

Synonym: S 4661

Target: Others

N-3-oxo-pentanoyl-L-Homoserine lactone

Cat.No: T37338

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T0224	Meropenem 美罗培南,SM 7338	Others; Antibacterial; Antibiotic	Microbiology/Virology; Others
	Meropenem (SM 7338) 是一种具有广谱抗菌活性的碳青霉烯抗生素，对敏感和耐药的淋病奈瑟氏球菌，流感嗜血杆菌和杜克氏杆菌的 MIC 值分别为 0.02-0.06 mg/mL，0.03-0.12 mg/mL 和 0.015-0.12 mg/mL。
T1505	Imipenem monohydrate N-Formimidoyl thienamycin monohydrate,亚胺培南,Imipenem,亚胺培南一水物	Antibacterial; Antibiotic	Microbiology/Virology
	Imipenem monohydrate (Imipenem) 是从微生物 Streptomyces cattleya 分离得到的碳青霉烯类抗生素，是一种用于静脉注射的β 内酰胺类抗生素，作用于细菌细胞壁，能广泛有效抑制多种革兰氏阳性和阴性菌。

天然产物

Cat.No: T0224

Synonym: 美罗培南,SM 7338

Target: Others, Antibacterial, Antibiotic

Imipenem monohydrate

Cat.No: T1505

Synonym: N-Formimidoyl thienamycin monohydrate,亚胺培南,Imipenem,亚胺培南一水物

Target: Antibacterial, Antibiotic

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPH-02368	KPC Protein, Klebsiella oxytoca, Recombinant (His & SUMO) Carbapenem-hydrolyzing beta-lactamase KPC-2,Car...	Klebsiella oxytoca	E. coli
	Hydrolyzes carbapenems, penicillins, cephalosporins and aztreonam with varying efficiency. KPC Protein, Klebsiella oxytoca, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 44.5 kDa and the accession number is Q848S6.
TMPH-02373	Metallo-beta-lactamase type 2 Protein, Klebsiella pneumoniae, Recombinant (His) Metallo-beta-lactamase type 2,B2 metallo-beta-lactamase,Meta...	Klebsiella pneumoniae	E. coli
	Confers resistance to the different beta-lactams antibiotics (penicillin, cephalosporin and carbapenem) via the hydrolysis of the beta-lactam ring. Does not confer resistance to the polymixin colistin or the fluoroquinolone ciprofloxacin.
TMPH-03488	Metallo-beta-lactamase type 2 Protein, Serratia marcescens, Recombinant (His & Myc) Metallo-beta-lactamase type 2,BLA-IMP,Metallo-beta-lactamase...	Serratia marcescens	E. coli
	Confers resistance to the different beta-lactams antibiotics (penicillin, cephalosporin and carbapenem) via the hydrolysis of the beta-lactam ring. Metallo-beta-lactamase type 2 Protein, Serratia marcescens, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 32.6 kDa and the accession number is P52699.

重组蛋白

KPC Protein, Klebsiella oxytoca, Recombinant (His & SUMO)

Cat.No: TMPH-02368

Species: Klebsiella oxytoca

Expression System: E. coli

Metallo-beta-lactamase type 2 Protein, Klebsiella pneumoniae, Recombinant (His)

Cat.No: TMPH-02373

Species: Klebsiella pneumoniae

Expression System: E. coli

Metallo-beta-lactamase type 2 Protein, Serratia marcescens, Recombinant (His & Myc)

Cat.No: TMPH-03488

Species: Serratia marcescens

Expression System: E. coli

Cat. No.	Product Name	Target	Signaling Pathways
TMIJ-0287	Meropenem-d6-1
	Meropenem-d6-1 是 Meropenem-1 的氘代化合物。Meropenem-1 的 CAS 号为 96036-03-2。Meropenem是一种具有广谱抗菌活性的碳青霉烯抗生素，对敏感和耐药的淋病奈瑟氏球菌，流感嗜血杆菌和杜克氏杆菌的 MIC 值分别为 0.02-0.06 mg/mL，0.03-0.12 mg/mL 和 0.015-0.12 mg/mL。
TMID-0072	Imipenem-d4
	Imipenem-d4 是 Imipenem 的氘代化合物。Imipenem 的 CAS 号为 64221-86-9。Imipenem (MK0787) 是一种噻吩霉素衍生物，属于抗生素类，具有抗菌活性，对革兰氏阳性和革兰氏阴性菌具有部分的抑制作用。Imipenem 可用于研究碳青霉烯类非易感性感染和铜绿假单胞菌生物膜感染。

同位素标记化合物

Cat.No: TMIJ-0287

Cat.No: TMID-0072

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