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Search Results for " bile acid "

Targets Recommended: GPCR19

60

抑制剂 & 化合物

56

天然产物

13

重组蛋白

11

同位素标记化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T7428	SBI-115	GPCR19	GPCR/G Protein
	SBI-115 是TGR5 (GPCR19)拮抗剂，对 TGR5 降低多囊性肝病的肝囊肿形成具有抑制作用。
TQ0252	BAR502	FXR; GPCR19; Autophagy	Autophagy; GPCR/G Protein; Metabolism
	BAR502 是一种 GPBAR1 和 FXR 双重激动剂，IC50分别为0.4 μM 和 2 μM。
T4083	BAR501 BAR 501	GPCR19	GPCR/G Protein
	BAR501是高效选择性的 GPBAR1激动剂(EC50:1 μM)。
T8599	Betazole dihydrochloride 盐酸倍他唑,Betazole hydrochloride	Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Betazole dihydrochloride (Betazole hydrochloride) 是吡唑类组胺，是一种口服活性 H2受体激动剂，能诱导胃酸分泌，导致胆总管压力立即显著升高。它作为一种诊断剂，用于研究胃酸分泌能力。
T4352	SB756050 SB-756050,SB 756050	GPCR19	GPCR/G Protein
	SB756050 是TGR5选择性激动剂。它用于二型糖尿病研究的潜力。
T11515	Gut restricted-7 GR-7	Potassium Channel	Membrane transporter/Ion channel
	Gut restricted-7 (GR-7) 是一种具有口服活性的共价泛胆盐水解酶 (BSH) 抑制剂，对肠道有组织选择性。它可减少小鼠粪便中肠道细菌的BSH 活性并降低去结合型胆汁酸水平。
T0843	Triamterene 氨苯蝶啶,Ademine,SKF8542	Sodium Channel; GPCR19	GPCR/G Protein; Membrane transporter/Ion channel
	Ademine 是一种压敏型上皮钠离子通道（ENaC）阻断剂，具有利尿的作用。
T1824	TGR5 Receptor Agonist	GPCR19	GPCR/G Protein
	TGR5 Receptor Agonist 是一种TGR5(GPCR19)激动剂。
T8818	TC-G 1005 (4-环丙基-3,4-二氢-1(2H)-喹喔啉基)[4-(2,5-二甲基苯氧基)-3-吡啶基]甲酮	GPCR19	GPCR/G Protein
	TC-G 1005 是具有口服活性的TGR5选择性激动剂，能够激活 hTGR5 (EC50:0.72 nM)和 mTGR5 (EC50:6.2 nM)。它能够减少小鼠体内葡萄糖水平。
T32873	Maralixibat Chloride SHP-625,SHP625,Livmarli,LUM001 chloride,Lopixibat chloride,Lopixibat,SHP625 chloride,SHP 625	Potassium Channel	Membrane transporter/Ion channel
	Maralixibat Chloride (LUM001 chloride) 是一种钠依赖性的胆汁酸转运抑制剂，可阻止胆汁酸在肠肝内的再循环
T13622	Cholestyramine Colestyramine,考来烯胺,Cholestyramine resin	Others	Others
	Cholestyramine (Cholestyramine resin) 是一种胆汁酸结合树脂，能够抑制肠胆汁酸吸收导致增加粪便胆汁酸排泄，提高胆固醇胆汁酸合成。
T35371	Colesevelam Hydrochloride	Others	Others
	Colesevelam Hydrochloride 是一种胆汁酸隔离剂，在体外对甘胆酸均具有更高的亲和力。 Colesevelam Hydrochloride 抑制胆汁酸重吸收，导致胆汁酸合成增加并降低胆汁淤积性瘙痒症和克罗恩病患者的胆固醇水平。
T36522	Isoallolithocholic acid Alloisolithocholic Acid,AILCA,3β-Hydroxy-5α-cholanic acid	Others	Others
	Isoallolithocholic acid (3β-Hydroxy-5α-cholanic acid) 是一种 T 细胞调节剂，是一种胆汁酸代谢物，具有抗炎活性，与人类免疫稳态有关。
T64334	Glycolithocholic acid, sodium salt	Others	Others
	Glycolithocholic acid, sodium salt 是 Glycolithocholic acid 的钠盐。Glycolithocholic acid 是一种甘氨酸结合的次级胆汁酸。Glycolithocholic acid 可用于诊断溃疡性结肠炎 (UC)，非酒精性脂肪性肝炎 (NASH0) 和原发性硬化性胆管炎 (PSC)。
T16376	Odevixibat A4250	Others	Others
	Odevixibat (A4250) (A4250) 是一种有效的选择性回肠胆汁酸转运蛋白 (IBAT) 抑制剂。Odevixibat (A4250) 可减轻小鼠模型中的胆汁淤积性肝和胆管损伤。Odevixibat (A4250)可用于原发性胆汁性肝硬化的研究。
T9154	Sodium taurodeoxycholate hydrate 牛磺去氧胆酸钠,Taurodeoxycholic acid sodium salt monohydrate	Others	Others
	Sodium taurodeoxycholate hydrate (Taurodeoxycholic acid sodium salt monohydrate) 已用于一项研究，以评估亚胶束浓度的胆汁盐对脂质双层膜的影响。
T15209	Elobixibat AZD 7806,A 3309	Others	Others
	Elobixibat (A 3309) 是回肠胆汁酸转运蛋白的抑制剂(小鼠、人和犬 IBAT 的 IC50：0.13 nM、0.53 nM 和 5.8 nM)。 Elobixibat 可用于慢性特发性便秘的研究。
TP1198	Sincalide ammonium SQ19844 ammonium,CCK-8 ammonium,Cholecystokinin octapeptide ammonium	cholecystokinin	GPCR/G Protein
	Sincalide ammonium (CCK-8 ammonium) 是一种有效的氨基酸多肽激素胆囊收缩素 (CCK) 的类似物，是保留了 CCK 的大部分生物活性的活性片段。Sincalide ammonium 促进胆汁的分泌，使胆囊收缩并使 Oddi 的括约肌松弛，从而促进胆汁排入十二指肠。Sincalide ammonium 可通过注射促进胆囊收缩，常用于辅助诊断胆囊、胰腺疾病和胆囊造影术。
T7294	Aramchol C20-FABAC	Others	Others
	Aramchol (C20-FABAC) 是一种胆酸和花生酸的结合物，能够降低硬脂酰辅酶 A 去饱和酶 1 (SCD1) 的活性。它具有用于非酒精性脂肪性肝病 (NAFLD) 和非酒精性脂肪性肝炎 (NASH) 的潜能。
T11426	Gly-β-MCA	FXR	Metabolism
	Gly-β-MCA 是一种具有口服生物活性、肠道选择性和有效的法尼酯X受体 (FXR) 抑制剂，是一种胆汁酸，可用于研究肥胖和糖尿病。
T65070	Chenodeoxycholic Acid sodium salt CDCA sodium salt	FXR	Metabolism
	Chenodeoxycholic Acid sodium salt (CDCA sodium salt) 是一种人体中的胆汁酸，能够活化核受体 FXR，可挽救痉挛性截瘫 5 型和脑黄瘤病患者诱导多能干细胞衍生神经元的轴突变性，可用于研究胰腺坏死。
T8752	BAR 501 impurity	GPCR19	GPCR/G Protein
	BAR 501 impurity 在 BAR501 制剂中发现的一种杂质，可作为 G 蛋白偶联胆汁酸激活受体 (GP-BAR1) 的激动剂。 BAR501 杂质 (10 µM) 在 GP-BAR1 报告基因检测中诱导荧光素酶活性增加 150%。
T37771	Taurolithocholic Acid 3-sulfate (sodium salt)	Others	Others
	Taurolithocholic acid 3-sulfate (TLCA3S) is a metabolite of the conjugated bile acid taurolithocholic acid . TLCA3S has been used to study bile acid transport in cellular models and to induce pancreatitis in mouse models of bile acid infusion pancreatitis.
T32420	Kryptogenin Cryptogenine,Cryptogenin	Others	Others
	Kryptogenin, derived from carp bile, can be used to synthesize C27-intermediates in bile acid biosynthesis.
T37845	Taurocholic Acid 3-sulfate (sodium salt)	Others	Others
	Taurocholic acid 3-sulfate (TCA3S) is a metabolite of the conjugated bile acid taurocholic acid .1Plasma levels of TCA3S are elevated in wild-type andSortilin 1(Sort1) knockout mice at 6 hours following bile duct ligation (BDL) and are further elevated inSort1knockout mice at 24 hours post-BDL.2 1.Lefebvre, P., Cariou, B., Lien, F., et al.Role of bile acids and bile acid receptors in metabolic regulationPhysiol. Rev.89(1)147-191(2009) 2.Li, J., Woolbright, B.L., Zhao, W., et al.Sortilin 1 loss-o...
T30270	Azidobenzamidotaurocholate	Others	Others
	Azido Benzamido Taurocholate is a bile acid transporter.
T85011	7,12-Diketolithocholic Acid 7,12-Dioxolithocholic Acid	Others	Others
	7,12-Diketolithocholic acid, a bile acid, exhibits elevated plasma levels in patients experiencing cholestasis.
T70688	S 0960	Others	Others
	S 0960 is a dimeric bile acid analogue that acts as a specific inhibitor of the apical sodium-dependent bile salt transporter (ASBT) in the ileum.
T32797	Lithocholenic acid	Others	Others
	Lithocholenic acid is a bile acid that acts as a detergent to solubilize fats for absorption.
T27015	Cicrotoic acid	Others	Others
	Cicrotoic acid, a biochemical drug, acts on bile flow and liquid composition of human bile.
T16818	S-8921	Others	Others
	S-8921 is an inhibitor of ileal Na+/bile acid cotransporter.
T2968L	Hyodeoxycholic acid sodium salt Sodium hyodeoxycholate,HDCA sodium	Others	Others
	Hyodeoxycholic acid sodium salt is a natural secondary bile acid. It improves high-density lipoprotein function, reduces farnesoid X receptor antagonist bile acids, and induces strong cytotoxicity, apoptosis, and IL-8 synthesis.
T69558	Barixibat	Others	Others
	Barixibat is a bile acid transport inhibitor.
T37178	Norhyodeoxycholic Acid	Others	Others
	Norhyodeoxycholic acid (NHDCA) is a synthetic bile acid and a derivative of hyodeoxycholic acid .1,2 NHDCA is an intermediate in the synthesis of 3β-sulfooxy-7β-hydroxy-24-nor-5-cholen-23-oic acid, which has been used as an internal standard for the quantification of δ5-bile acid conjugates that have been identified in patients with Niemann-Pick disease type C1.3 \|1. Schteingart, C.D., and Hofmann, A.F. Synthesis of 24-nor-5β-cholan-23-oic acid derivatives: A convenient and efficient one-carbon ...
T28700	SC-435 mesylate SC-435,SC435,SC 435	Others	Others
	SC-435 is an ileal apical sodium co-dependent bile acid transporter (ASBT). SC-435 inhibits plasma cholesterol.
T10090	264W94	Others	Others
	264W94 is a robust inhibitor of the ileal bile acid transporter (IBAT) and a novel agent for reducing cholesterol levels. It exhibits CYP7A1 induction and demonstrates significant antilipemic activity.
T17236	Volixibat SHP626,LUM002	Others	Others
	Volixibat is a highly selective and competitive apical sodium-dependent bile acid transporter inhibitor. Volixibat has the potential for treatment for non-alcoholic steatohepatitis.
T83900	12β-Hydroxyisocholic Acid LCA,Lagocholic Acid	Others	Others
	12β-Hydroxyisocholic acid是一种胆酸，同时也是胆酸的异构体。在酒精性肝损伤的小鼠模型中，12β-Hydroxyisocholic acid的肝脏水平会升高。
T69622	Ritivixibat	Others	Others
	Ritivixibat为回肠胆汁酸转运蛋白(IBAT)抑制剂，同时也是胆汁酸调节剂，主要适用于心血管疾病、脂肪酸代谢及葡萄糖利用障碍、胃肠道和肝脏疾病的研究。
T36075	Cholic Acid anilide	Others	Others
	Cholic acid anilide is a synthetic bile acid and derivative of cholic acid that inhibits the germination of C. difficile strain R20291 spores in vitro (IC50 = 1.8 μM).1 \|1. Sharma, S.K., Yip, C., Esposito, E.X., et al. The design, synthesis, and characterizations of spore germination inhibitors effective against an epidemic strain of Clostridium difficile. J. Med. Chem. 61(15), 6759-6778 (2018).
T75599	Glycodehydrocholic acid	Others	Others
	Glycodehydrocholic acid，一种胆汁酸与甘氨酸的结合物，主要用于诊断癌症及其他疾病。
T37416	Tauro-α-muricholic Acid (sodium salt)	Others	Others
	Tauro-α-muricholic acid (TαMCA) is an antagonist of the farnesoid X receptor (FXR; IC50 = 28 μM) and a taurine-conjugated form of the murine-specific primary bile acid α-muricholic acid . TαMCA is common in rodents but has also been found in small amounts in human serum.
T37846	Taurohyocholic Acid (sodium salt)	Others	Others
	Taurohyocholic acid (THCA) is a taurine-conjugated form of the porcine-specific primary bile acid hyocholic acid .1THCA inhibits precipitation of cholesterol crystals by stabilizing cholesterol in the liquid-crystalline phase.2It prevents cholestasis and cellular necrosis induced by taurolithocholic acid in isolated rat livers.3THCA levels are increased in the urine of patients with hepatitis B-induced cirrhosis.4
T37798	Petromyzonol	Others	Others
	Petromyzonol is a tetrahydroxy stearol which serves as the primary spawning pheromone in adult sea lamprey. It is produced in the bile of sea lamprey larvae from the bile acid precursor allocholic acid. While the adult sea lamprey is relatively insensitive to petromyzonol itself, the C-24 sulfate ester (petromyzonol sulfate) is a pheromone and a spawning chemoattractant which can be detected at very low concentrations by lamprey olfactory chemoreceptors. Petromyzonol, petromyzonol sulfate, and a...
T85281	Taurohyocholic Acid sodium Taurohyocholate,THCA,Tauro-γ-muricholic Acid,Taurine Hyocholate	Others	Others
	Taurohyocholic acid (THCA), a taurine-conjugated form of porcine-specific primary bile acid hyocholic acid, inhibits cholesterol crystal precipitation by stabilizing cholesterol in the liquid-crystalline phase and prevents cholestasis and cellular necrosis in isolated rat livers induced by taurolithocholic acid. Additionally, THCA levels rise in the urine of patients with hepatitis B-induced cirrhosis.
T84944	3-Epideoxycholic Acid EDCA	Others	Others
	3-Epideoxycholic acid (EDCA), a secondary bile acid and an epimer of deoxycholic acid, serves as a steroidal host compound in the enantioselective purification of (2R,3S)-3-methyl-2-pentanol from its racemates via enclathration. Additionally, decreased fecal levels of EDCA have been observed in pediatric patients with non-alcoholic fatty liver disease (NAFLD).
T63793	Tauro-ω-muricholic acid sodium	Others	Others
	Tauro-ω-muricholic acid sodium (TωMCA sodium) 是一种tauro-α-muricholic acid 的类似物，是来源于肝脏的胆汁酸。Tauro-ω-muricholic acid sodium 能用作早发性新生儿败血症 (EOS) 和胆汁淤积的血清标志物。
T36132	3β-OH-7-Oxocholenic Acid	Others	Others
	3β-OH-7-Oxocholenic acid is a bile acid.1 It is also a metabolite of 7β-hydroxy cholesterol in rats. Conjugated forms of 3β-OH-7-oxocholenic acid have been found in the urine of patients with Neimann-Pick disease type C.2,3 \|1. Norii, T., Yamaga, N., and Yamasaki, K. Metabolism of 7β-hydroxycholesterol-4-14C in rat. Steroids 15(3), 303-326 (1970).\|2. Alvelius, G., Hjalmarson, O., Griffiths, W.J., et al. Identification of unusual 7-oxygenated bile acid sulfates in a patient with Niemann-Pick dise...
T37854	Cholic Acid 7-sulfate	Others	Others
	Cholic acid 7-sulfate is a metabolite of the primary bile acid cholic acid.[1],[2] It is produced by conjugation of a sulfate group with the hydroxy group at position 7 of cholic acid in the liver and gut. Fecal levels of cholic acid 7-sulfate are increased in male, but not female, mice fed a diet supplemented with cholic acid or chenodeoxycholic acid.[2]
T37251	Celecoxib Carboxylic Acid Acyl-β-D-Glucuronide	Others	Others
	Celecoxib carboxylic acid acyl-β-D-glucuronide is a phase II metabolite of celecoxib . Celecoxib is an anti-inflammatory compound from the diaryl heterocycle class that selectively inhibits cyclooxygenase-2 (COX-2; IC50s = 22.9 and 0.05 μM for COX-1 and COX-2, respectively). Celecoxib carboxylic acid acyl-β-D-glucuronide is a minor metabolite, accounting for 2% of the administered dose in human urine and rat bile.

化合物

Cat.No: T7428

Target: GPCR19

Cat.No: TQ0252

Target: FXR, GPCR19, Autophagy

Cat.No: T4083

Synonym: BAR 501

Target: GPCR19

Betazole dihydrochloride

Cat.No: T8599

Synonym: 盐酸倍他唑,Betazole hydrochloride

Target: Histamine Receptor

Cat.No: T4352

Synonym: SB-756050,SB 756050

Target: GPCR19

Gut restricted-7

Cat.No: T11515

Synonym: GR-7

Target: Potassium Channel

Cat.No: T0843

Synonym: 氨苯蝶啶,Ademine,SKF8542

Target: Sodium Channel, GPCR19

TGR5 Receptor Agonist

Cat.No: T1824

Target: GPCR19

Cat.No: T8818

Synonym: (4-环丙基-3,4-二氢-1(2H)-喹喔啉基)[4-(2,5-二甲基苯氧基)-3-吡啶基]甲酮

Target: GPCR19

Maralixibat Chloride

Cat.No: T32873

Synonym: SHP-625,SHP625,Livmarli,LUM001 chloride,Lopixibat chloride,Lopixibat,SHP625 chloride,SHP 625

Target: Potassium Channel

Cat.No: T13622

Synonym: Colestyramine,考来烯胺,Cholestyramine resin

Target: Others

Colesevelam Hydrochloride

Cat.No: T35371

Target: Others

Isoallolithocholic acid

Cat.No: T36522

Synonym: Alloisolithocholic Acid,AILCA,3β-Hydroxy-5α-cholanic acid

Target: Others

Glycolithocholic acid, sodium salt

Cat.No: T64334

Target: Others

Cat.No: T16376

Synonym: A4250

Target: Others

Sodium taurodeoxycholate hydrate

Cat.No: T9154

Synonym: 牛磺去氧胆酸钠,Taurodeoxycholic acid sodium salt monohydrate

Target: Others

Cat.No: T15209

Synonym: AZD 7806,A 3309

Target: Others

Sincalide ammonium

Cat.No: TP1198

Synonym: SQ19844 ammonium,CCK-8 ammonium,Cholecystokinin octapeptide ammonium

Target: cholecystokinin

Cat.No: T7294

Synonym: C20-FABAC

Target: Others

Cat.No: T11426

Target: FXR

Chenodeoxycholic Acid sodium salt

Cat.No: T65070

Synonym: CDCA sodium salt

Target: FXR

BAR 501 impurity

Cat.No: T8752

Target: GPCR19

Taurolithocholic Acid 3-sulfate (sodium salt)

Cat.No: T37771

Target: Others

Cat.No: T32420

Synonym: Cryptogenine,Cryptogenin

Target: Others

Taurocholic Acid 3-sulfate (sodium salt)

Cat.No: T37845

Target: Others

Azidobenzamidotaurocholate

Cat.No: T30270

Target: Others

7,12-Diketolithocholic Acid

Cat.No: T85011

Synonym: 7,12-Dioxolithocholic Acid

Target: Others

Cat.No: T70688

Target: Others

Lithocholenic acid

Cat.No: T32797

Target: Others

Cicrotoic acid

Cat.No: T27015

Target: Others

Cat.No: T16818

Target: Others

Hyodeoxycholic acid sodium salt

Cat.No: T2968L

Synonym: Sodium hyodeoxycholate,HDCA sodium

Target: Others

Cat.No: T69558

Target: Others

Norhyodeoxycholic Acid

Cat.No: T37178

Target: Others

SC-435 mesylate

Cat.No: T28700

Synonym: SC-435,SC435,SC 435

Target: Others

Cat.No: T10090

Target: Others

Cat.No: T17236

Synonym: SHP626,LUM002

Target: Others

12β-Hydroxyisocholic Acid

Cat.No: T83900

Synonym: LCA,Lagocholic Acid

Target: Others

Cat.No: T69622

Target: Others

Cholic Acid anilide

Cat.No: T36075

Target: Others

Glycodehydrocholic acid

Cat.No: T75599

Target: Others

Tauro-α-muricholic Acid (sodium salt)

Cat.No: T37416

Target: Others

Taurohyocholic Acid (sodium salt)

Cat.No: T37846

Target: Others

Cat.No: T37798

Target: Others

Taurohyocholic Acid sodium

Cat.No: T85281

Synonym: Taurohyocholate,THCA,Tauro-γ-muricholic Acid,Taurine Hyocholate

Target: Others

3-Epideoxycholic Acid

Cat.No: T84944

Synonym: EDCA

Target: Others

Tauro-ω-muricholic acid sodium

Cat.No: T63793

Target: Others

3β-OH-7-Oxocholenic Acid

Cat.No: T36132

Target: Others

Cholic Acid 7-sulfate

Cat.No: T37854

Target: Others

Celecoxib Carboxylic Acid Acyl-β-D-Glucuronide

Cat.No: T37251

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T2965	Deoxycholic acid Cholorebic,去氧胆酸,脱氧胆酸,Deoxycholate,Desoxycholic acid,Cholanoic Acid,Cholerebic	Endogenous Metabolite; GPCR19	GPCR/G Protein; Metabolism
	Deoxycholic acid (Cholanoic Acid) 是 G 蛋白偶联胆汁酸受体 TGR5的激活剂。
T5077	Deoxycholic acid sodium salt 脱氧胆酸钠,Sodium deoxycholate,Sodium Desoxycholate	Endogenous Metabolite; GPCR19	GPCR/G Protein; Metabolism
	Deoxycholic acid sodium salt (Sodium deoxycholate) 是 G 蛋白偶联胆汁酸受体TGR5的激活剂。
T8153	glycohyodeoxycholic acid	Others; Endogenous Metabolite	Metabolism; Others
	Glycohyodeoxycholic acid 是一种人体次级胆汁酸猪去氧胆酸的主要代谢物，能够预防胆结石的形成。
T19189	Allocholic acid	Others	Others
	Allocholic acid 是一种胆汁酸，在脊椎动物中发现，在肝脏再生和致癌过程中会重新出现，也是成熟嗅觉系统的特定性刺激物。
T0022	Taurine 牛磺酸,2-Aminoethanesulfonic acid	LDL; Endogenous Metabolite; Autophagy	Autophagy; Metabolism
	Taurine (2-Aminoethanesulfonic acid) 是一种含硫氨基酸的有机渗透剂，为胆汁盐的形成提供底物，并在调节细胞内游离钙浓度方面发挥作用，有激活脂肪细胞自噬的能力。
T0700	Ursodeoxycholic acid 熊去氧胆酸,UDCA,Ursodiol	Potassium Channel; Endogenous Metabolite	Membrane transporter/Ion channel; Metabolism
	Ursodeoxycholic acid (UDCA)是一种有效的肝脏特异性脂肪酸转运蛋白 5 (FATP5) 抑制剂，通过 FATP5 依赖性方式抑制原代肝细胞摄取长链脂肪酸。Ursodeoxycholic acid 能够抑制胆固醇的吸收，用于溶解胆结石，并具有研究与肥胖相关的脂肪肝疾病的潜力。
T31964	Glycolithocholic acid Lithocholic acid glycine conjugate,甘氨石胆酸,Lithocholylglycine	Endogenous Metabolite	Metabolism
	Glycolithocholic acid (Lithocholic acid glycine conjugate) 属于内源性代谢产物，是甘氨酸结合的次级胆汁酸。它可用于诊断非酒精性脂肪性肝炎，溃疡性结肠炎和原发性硬化性胆管炎。
T2968	Hyodeoxycholic acid NSC 60672,猪去氧胆酸,α-Hyodeoxycholic Acid,HDCA	FXR; Endogenous Metabolite; GPCR19	GPCR/G Protein; Metabolism
	Hyodeoxycholic acid (NSC 60672) 是由肠道菌群在小肠中形成的次级胆汁酸，是TGR5(GPCR19)的激动剂， CHO 细胞中的EC50=31.6 µM。它已用于研究高胆固醇血症的治疗。
T13502	3-Oxo-5β-cholanoic acid 3-氧代-5β-胆烷酸,Dehydrolithocholic acid	ROR	Metabolism
	3-Oxo-5β-cholanoic acid (Dehydrolithocholic acid) 是胆汁酸的一种代谢产物。3-Oxo-5β-cholanoic acid 直接与关键转录因子RORγt(Kd=1.13 μM) 结合抑制TH17细胞分化。
T13522	7-Ketolithocholic acid 3α-Hydroxy-7-oxo-5β-cholanic acid	Endogenous Metabolite	Metabolism
	7-Ketolithocholic acid (3α-Hydroxy-7-oxo-5β-cholanic acid) (3α-Hydroxy-7-oxo-5β-cholanic acid) is capable of absorption and serves to suppress the production of endogenous bile acid and the secretion of biliary cholesterol.
T29078	Ursodeoxycholic acid sodium UDCA Na,UDCA sodium,Sodium Ursodeoxycholate,熊去氧胆酸钠盐,Ursodiol sodium,Ursodeoxycholic Acid (sodium salt),Ursodeoxycholate sodium	FXR; Endogenous Metabolite; GPCR19	GPCR/G Protein; Metabolism
	Ursodeoxycholic acid sodium (Sodium Ursodeoxycholate) 是一种天然存在的次级胆汁酸，具有抗炎和细胞保护活性。Ursodeoxycholic acid sodium 作为信号分子，通过与胆汁酸激活受体相互作用发挥其作用，包括 G 蛋白偶联胆汁酸受体 5 (TGR5) 和法尼醇 X 受体 (FXR)。
TN2215	Taurochenodeoxycholic acid sodium 牛磺鹅去氧胆酸钠盐,Sodium taurochenodeoxycholate,牛磺鹅去氧胆酸钠	Apoptosis; Endogenous Metabolite	Apoptosis; Metabolism
	Taurochenodeoxycholic acid sodium (Sodium taurochenodeoxycholate) 是动物胆汁酸的主要生物活性物质之一。它可诱导细胞凋亡，具有抗炎和免疫调节作用。
T2A2481	Taurochenodeoxycholic Acid Chenodeoxycholyltaurine,TCDCA,Chenyltaurine,Taurochenodeoxycholate,12-Deoxycholyltaurine,牛磺鹅去氧胆酸	Apoptosis; TNF; Caspase; Endogenous Metabolite	Apoptosis; Metabolism; Proteases/Proteasome
	Taurochenodeoxycholic Acid (12-Deoxycholyltaurine) 是动物胆汁酸的主要生物活性物质之一，可诱导细胞凋亡，具有明显的抗炎和免疫调节作用。
T5234	Glycoursodeoxycholic acid Ursodeoxycholylglycine,甘氨熊胆酸,GUDCA	Others; Endogenous Metabolite	Metabolism; Others
	Glycoursodeoxycholic acid (Ursodeoxycholylglycine) 是一种酰基甘氨酸和胆汁酸-甘氨酸缀合物，是熊去氧胆酸的代谢物。
T13505	3α,12β-Dihydroxycholanoic acid Lagodeoxycholic acid	Endogenous Metabolite	Metabolism
	3α,12β-Dihydroxycholanoic acid (Lagodeoxycholic acid) 是一种广泛存在于动物体内的胆汁酸。
T19124	3-Oxocholic acid 3-Ketocholic acid	Endogenous Metabolite	Metabolism
	3-Oxocholic acid(3-Ketocholic acid) 是胆汁酸的代谢产物，也是产气荚膜梭菌在肠道中由胆汁降解的主要产物。33-Oxocholic acid 是一种主要存在于哺乳动物的胆汁中类固醇酸。
T2744	Methyl Cholate 胆酸甲酯,Cholic acid methyl ester	Others	Others
	Methyl Cholate 是胆酸的甲酯形式。其中胆酸是一种由肝脏产生的主要胆汁酸，由胆固醇合成。Methyl Cholate 具有抗炎抗肿瘤活性。
T0516	Dehydrocholate sodium 去氢胆酸钠,Sodium dehydrocholate	Endogenous Metabolite; Lipid	Metabolism
	Dehydrocholate sodium 是胆液排泄增多剂，能够提高胆汁输出，清除提高的胆汁酸负载。
T7331	Ursocholic acid	Endogenous Metabolite	Metabolism
	Ursocholic acid 是存在于哺乳动物胆汁中的胆酸，通过小鼠肠道菌群转化为脱氧胆酸。脱氧胆酸是7α-羟化类固醇脱氢酶和肝细胞核因子1α的抑制剂。
T5072	Glycocholic acid hydrate	Others; Endogenous Metabolite	Metabolism; Others
	Glycocholic acid hydrate 是内源性代谢产物的一种。
T10196	7α-Hydroxy-4-cholesten-3-one 7-hydroxy-4-cholesten-3-one	Others	Others
	7α-Hydroxy-4-cholesten-3-one 是一种可穿过血脑屏障的胆汁酸前体，可作为肝胆汁酸合成的指标。7α-Hydroxy-4-cholesten-3-one 是一种孕烷 X 受体 (PXR) 激动剂。7α-Hydroxy-4-cholesten-3-one 可用于研究与胆汁酸生物合成缺陷有关的疾病。
TJA2398	Taurodeoxycholic acid sodium hydrate Sodium taurodeoxycholate monohydrate,Taurodeoxychloic Acid sodium hydrate,Taurohyodeoxycholic acid sodium salt,牛磺猪去氧胆酸	Apoptosis; Caspase	Apoptosis; Proteases/Proteasome
	Taurodeoxycholic acid sodium hydrate (Sodium taurodeoxycholate monohydrate) 通过阻断钙介导的凋亡通路和 Caspase-12的活化来阻止细胞凋亡。它可用于原发性胆汁性肝硬化、胰岛素抵抗、淀粉样变性、囊性纤维化、胆汁淤积和肌萎缩侧索硬化症。
T7628	3b-Hydroxy-5-cholenoic acid	Endogenous Metabolite	Metabolism
	3b-Hydroxy-5-cholenoic acid 是内源性的单羟基胆酸的一种，大量崔乃在于患有肝胆管状发育不全的儿童体内。
T4727	Taurolithocholic acid sodium salt 牛磺石胆酸钠,Sodium taurolithocholate	Others; Calcium Channel	Membrane transporter/Ion channel; Metabolism; Others
	Taurolithocholic acid sodium salt (Sodium taurolithocholate) 是抑胆剂和 Ca2+激动剂，可抑制放射性配体与毒蕈碱 M1 结合。
T2963	Cholic Acid Cholanic acid,胆汁酸,Cholate,Colalin	Endogenous Metabolite	Metabolism
	Cholic Acid (Cholate) 是肝脏产生的主要胆汁酸，与牛磺酸或甘氨酸缀合，有助于脂肪吸收和胆固醇排泄。
T8207	Evolitrine	Others	Others
	Evolitrine 是一种来源于Acronychia pedunculata、具有抗炎作用的物质。
T14002	12-Ketodeoxycholic acid	Endogenous Metabolite	Metabolism
	12-Ketodeoxycholic acid 是一种胆汁酸，由肾脏代谢产生。它是肾脏损伤的标志物。
T0408	Dehydrocholic acid Dehystolin,Felacrinos,去氢胆酸,Sanocholen,Decholin	Others	Others
	Dehydrocholic acid (Dehystolin) 是一种由胆酸氧化生成的胆汁酸，用作胆液排泄增多剂，能够增加胆汁产量，清除增加的胆汁酸负荷。
T35792	Isolithocholic Acid 3-Epilithocholic acid,3β-Hydroxy-5β-cholanic acid,β-Lithocholic acid,isoLCA	Endogenous Metabolite	Metabolism
	Isolithocholic Acid (3-Epilithocholic acid) (β-Lithocholic acid) 是石胆酸的一种同分异构体。Isolithocholic Acid 是一种胆酸，由 Lithocholic acid 或 Lithocholic acid 3α-sulfate 经微生物代谢形成。
T2831	Glycocholic acid Glycocholate,甘氨胆酸,cholylglycine	Others; Endogenous Metabolite	Metabolism; Others
	Glycocholic acid (Glycocholate) 是一种胆汁酸，具有抗肿瘤活性，能够靶向作用于耐药泵和非耐药泵通路。
T37177	Norcholic Acid	Others	Others
	Norcholic acid is a bile acid and 23-carbon derivative of cholic acid .1Levels of norcholic acid are increased in the urine of patients with liver cirrhosis or cerebrotendinous xanthomatosis (CTX), an inborn error of metabolism characterized by a deficiency in the mitochondrial enzyme sterol 27-hydrolylase (CYP27A1) that leads to progressive neurological symptoms.2,3,4
T4588	Glycochenodeoxycholic Acid 甘氨鹅脱氧胆酸,Glycine chenodeoxycholate,Chenodeoxycholylglycine,GCDCA,Glycochenodeoxycholate,Lithocholylglycine	Apoptosis; Endogenous Metabolite	Apoptosis; Metabolism
	Glycochenodeoxycholic Acid (Lithocholylglycine) 是一种从脱氧鹅胆酸和甘氨酸在肝脏中形成的胆汁盐，可诱导肝细胞凋亡。它有洗涤剂的作用，可溶解脂肪吸收，并本身被吸收。
T8294	Quercetagitrin 万寿菊苷,槲皮万寿菊素-7-O-Β-吡喃葡萄糖苷,Quercetagetin-7-O-glucoside	Others	Others
	Quercetagitrin 是分离自非洲万寿菊花 (Tagetes erecta) 中，具有抗炎作用。
T4070	Glycocholic Acid Sodium Salt Glycocholate Sodium,Sodium Glycocholate,甘氨胆酸钠盐	Others	Others
	Glycocholic Acid Sodium Salt (Sodium Glycocholate) 是一种结合胆汁盐和离子生物去污剂。它参与脂肪的乳化。
T5259	Glycochenodeoxycholic acid sodium salt GCDCA,甘氨鹅脱氧胆酸钠,Sodium glycochenodeoxycholate	Apoptosis; Others; Endogenous Metabolite	Apoptosis; Metabolism; Others
	Glycochenodeoxycholic acid sodium salt 是一种从脱氧鹅胆酸和甘氨酸在肝脏中形成的胆汁盐，可诱导肝细胞凋亡。它起到洗涤剂的作用，可溶解脂肪吸收，并本身被吸收。
TWA2417	Sodium taurocholate 牛黄胆酸钠(牛胆酸钠，牛胆酸钠盐，牛磺膽酸鈉，牛磺胆酸钠，牛磺胆酸钠盐，牛胆酸钠水合物，水合牛磺胆酸钠，牛胆酸钠(混合物)，牛黄胆酸钠(水合)，牛磺胆酸钠(标准品)),Taurocholate Sodium	Others	Others
	Sodium taurocholate (Taurocholate Sodium) hydrate 具有显著的生物学效应，例如通过上调 VEGF-A 的表达抑制肝动脉结扎所致的胆道损伤。对免疫系统具有一定的调节作用。
TN2259	Taurocholic acid N-Choloyltaurine	TNF; PI3K	Apoptosis; PI3K/Akt/mTOR signaling
	Taurocholic acid (N-Choloyltaurine) 是一种胆汁酸，参与脂肪的乳化。Taurocholic acid 具有细胞保护作用，可通过 PI3K 介导的途径防止肿瘤坏死因子-α 诱导的胆管细胞损伤。
T2532	Tauroursodeoxycholate Taurolite,牛磺熊去氧胆酸,Tauroursodeoxycholic Acid,UR 906,Ursodeoxycholyltaurine,TUDCA	Apoptosis; ERK; P450; Caspase; Endogenous Metabolite	Apoptosis; MAPK; Metabolism; Proteases/Proteasome
	Tauroursodeoxycholate (UR 906) 是一种天然的高度亲水性的三级胆汁酸。Tauroursodeoxycholate 可用于原发性胆汁性肝硬化 (PBC)、胰岛素抵抗、淀粉样变性、囊性纤维化、胆汁淤滞和肌萎缩性侧索硬化症的研究。
T13506	3β-Ursodeoxycholic acid Isoursodeoxycholic acid
	3β-Ursodeoxycholic acid (Isoursodeoxycholic acid) 是一种胆汁酸。3β-Ursodeoxycholic acid 经口服给药表现出良好的耐受性和良好的肠道吸收能力。3β-Ursodeoxycholic acid 可以在肠道和肝脏经历酶异构化，并生成UDCA。
T1138	Taurocholic acid sodium salt hydrate 牛胆酸钠,牛磺胆酸钠水合物,Sodium taurocholate hydrate,Taurocholic Acid sodium hydrate	Others; Potassium Channel; Endogenous Metabolite	Membrane transporter/Ion channel; Metabolism; Others
	Taurocholic acid sodium salt hydrate (Sodium taurocholate hydrate) 是一种胆汁酸钠盐水合物，作用是参与脂肪的乳化。
T2202	Lithocholic acid 3α-Hydroxy-5β-cholanic acid,石胆酸	Apoptosis; Others; FXR; Endogenous Metabolite; Autophagy	Apoptosis; Autophagy; Metabolism; Others
	Lithocholic acid (3α-Hydroxy-5β-cholanic acid) 是由鹅去氧胆酸盐通过细菌作用形成的胆汁酸，通常与甘氨酸或牛磺酸结合，被用作利胆剂。它作为清洁剂溶解脂肪以供吸收，并且本身被吸收。
T75319	Taurodeoxycholic acid Taurodeoxychloic acid	Apoptosis; Calcium Channel; Caspase	Apoptosis; Membrane transporter/Ion channel; Metabolism; Proteases/Proteasome
	Taurodeoxycholic acid (Taurodeoxychloic acid) 是脱氧胆酸的胆汁酸牛磺酸共轭物，是一种人体代谢物，可稳定线粒体膜，减少自由基形成。Taurodeoxycholic acid 通过阻断钙介导的凋亡通路以及 Caspase-12 激活来抑制凋亡 (apoptosis)。Taurodeoxycholic acid具有神经保护活性，可用于研究 3-硝基丙酸诱导或稳定遗传的亨廷顿舞蹈病 (HD) 。
T0847	Chenodeoxycholic acid CDCA,鹅去氧胆酸,Chenodiol	Potassium Channel; FXR; Endogenous Metabolite; Autophagy	Autophagy; Membrane transporter/Ion channel; Metabolism
	Chenodeoxycholic acid (CDCA) 是一种胆汁酸，通常与甘氨酸或牛磺酸结合。它作为清洁剂溶解脂肪以供肠道吸收，并被小肠重新吸收。它被用作利胆剂、利胆泻药，以及预防或溶解胆结石。
T5254	Glycodeoxycholate Sodium Sodium glycyldeoxycholate,Sodium glycodeoxycholate,Glycodeoxycholic acid sodium salt,脱氧甘胆酸钠	Others; Endogenous Metabolite	Metabolism; Others
	Glycodeoxycholate Sodium 诱导肝细胞凋亡的机制与内切酶的DNA裂解有关。它是一种次级胆汁酸，由结肠环境中微生物菌群中存在的酶的作用产生。
T15245	Erythromycin estolate Phtalic anhydride,ilosone	Antibacterial	Microbiology/Virology
	Erythromycin estolate 是红霉素的衍生物，属于大环内酯类抗生素，常用于研究多种细菌感染。酯酸红霉素对胆汁酸转运有抑制作用，可引起肝损伤，主要是胆汁淤积性肝炎。
TN6909	Polyporusterone B 猪苓酮B,(1R,2R,4S,5R,7R,11R,14S,15R)-14-[(2R,3R)-2,3-dihydroxy-6-methyl-5-methylideneheptan-2-yl]-4,5,11-trihydroxy-2,15-dimethyltetracyclo[8.7.0.02,?.011,1?]heptadec-9-en-8-one	Others	Others
	Polyporusterone B ((1R,2R,4S,5R,7R,11R,14S,15R)-14-[(2R,3R)-2,3-dihydroxy-6-methyl-5-methylideneheptan-2-yl]-4,5,11-trihydroxy-2,15-dimethyltetracyclo[8.7.0.02,?.011,1?]heptadec-9-en-8-one) 是一种三萜羧酸，从Polyporus umbellatusFries 中分离得到。它对自由基诱导的红细胞裂解 (溶血) 具有抑制作用。
T36585	Isodeoxycholic Acid isoDCA	Chloride channel; Antibacterial	Membrane transporter/Ion channel; Microbiology/Virology
	Isodeoxycholic Acid 是一种胆汁酸，由肠道细菌通过脱氧胆酸的表聚作用形成。Isodeoxycholic acid 的临界胶束浓度高于二氯苯甲醚，这表明它的去污活性降低了，而且在抑制七种肠道共生细菌生长方面的活性低于二氯苯甲醚。Isodeoxycholic Acid（0.1%）能抑制几种艰难梭菌菌株在牛磺胆酸诱导下的孢子萌发，并能降低艰难梭菌培养上清对 Vero 细胞的细胞毒性。在高脂饮食诱发肥胖的大鼠模型中，血浆中的Isodeoxycholic acid 水平比正常饮食的大鼠低。
T19623	α-Muricholic acid	AChR	Neuroscience
	α-Muricholic acid is the most abundant primary bile acid in rodents.
T40790	ω-Muricholic Acid	Others	Others
	ω-Muricholic acid (ω-MCA) is a murine-specific secondary bile acid.
T81030	Tauro-β-muricholic acid TβMCA	FXR	Metabolism
	Tauro-β-muricholic acid (TβMCA) 为一种具有三羟基结构的胆汁酸，是FXR的竞争性、可逆拮抗剂，IC50值为40 μM。此外，Tauro-β-muricholic acid 能够通过维持线粒体膜电位来阻抑胆汁酸引起的肝细胞凋亡，发挥抗凋亡功能。
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天然产物

Deoxycholic acid

Cat.No: T2965

Synonym: Cholorebic,去氧胆酸,脱氧胆酸,Deoxycholate,Desoxycholic acid,Cholanoic Acid,Cholerebic

Target: Endogenous Metabolite, GPCR19

Deoxycholic acid sodium salt

Cat.No: T5077

Synonym: 脱氧胆酸钠,Sodium deoxycholate,Sodium Desoxycholate

Target: Endogenous Metabolite, GPCR19

glycohyodeoxycholic acid

Cat.No: T8153

Target: Others, Endogenous Metabolite

Allocholic acid

Cat.No: T19189

Target: Others

Cat.No: T0022

Synonym: 牛磺酸,2-Aminoethanesulfonic acid

Target: LDL, Endogenous Metabolite, Autophagy

Ursodeoxycholic acid

Cat.No: T0700

Synonym: 熊去氧胆酸,UDCA,Ursodiol

Target: Potassium Channel, Endogenous Metabolite

Glycolithocholic acid

Cat.No: T31964

Synonym: Lithocholic acid glycine conjugate,甘氨石胆酸,Lithocholylglycine

Target: Endogenous Metabolite

Hyodeoxycholic acid

Cat.No: T2968

Synonym: NSC 60672,猪去氧胆酸,α-Hyodeoxycholic Acid,HDCA

Target: FXR, Endogenous Metabolite, GPCR19

3-Oxo-5β-cholanoic acid

Cat.No: T13502

Synonym: 3-氧代-5β-胆烷酸,Dehydrolithocholic acid

Target: ROR

7-Ketolithocholic acid

Cat.No: T13522

Synonym: 3α-Hydroxy-7-oxo-5β-cholanic acid

Target: Endogenous Metabolite

Ursodeoxycholic acid sodium

Cat.No: T29078

Synonym: UDCA Na,UDCA sodium,Sodium Ursodeoxycholate,熊去氧胆酸钠盐,Ursodiol sodium,Ursodeoxycholic Acid (sodium salt),Ursodeoxycholate sodium

Target: FXR, Endogenous Metabolite, GPCR19

Taurochenodeoxycholic acid sodium

Cat.No: TN2215

Synonym: 牛磺鹅去氧胆酸钠盐,Sodium taurochenodeoxycholate,牛磺鹅去氧胆酸钠

Target: Apoptosis, Endogenous Metabolite

Taurochenodeoxycholic Acid

Cat.No: T2A2481

Synonym: Chenodeoxycholyltaurine,TCDCA,Chenyltaurine,Taurochenodeoxycholate,12-Deoxycholyltaurine,牛磺鹅去氧胆酸

Target: Apoptosis, TNF, Caspase, Endogenous Metabolite

Glycoursodeoxycholic acid

Cat.No: T5234

Synonym: Ursodeoxycholylglycine,甘氨熊胆酸,GUDCA

Target: Others, Endogenous Metabolite

3α,12β-Dihydroxycholanoic acid

Cat.No: T13505

Synonym: Lagodeoxycholic acid

Target: Endogenous Metabolite

3-Oxocholic acid

Cat.No: T19124

Synonym: 3-Ketocholic acid

Target: Endogenous Metabolite

Cat.No: T2744

Synonym: 胆酸甲酯,Cholic acid methyl ester

Target: Others

Dehydrocholate sodium

Cat.No: T0516

Synonym: 去氢胆酸钠,Sodium dehydrocholate

Target: Endogenous Metabolite, Lipid

Ursocholic acid

Cat.No: T7331

Target: Endogenous Metabolite

Glycocholic acid hydrate

Cat.No: T5072

Target: Others, Endogenous Metabolite

7α-Hydroxy-4-cholesten-3-one

Cat.No: T10196

Synonym: 7-hydroxy-4-cholesten-3-one

Target: Others

Taurodeoxycholic acid sodium hydrate

Cat.No: TJA2398

Synonym: Sodium taurodeoxycholate monohydrate,Taurodeoxychloic Acid sodium hydrate,Taurohyodeoxycholic acid sodium salt,牛磺猪去氧胆酸

Target: Apoptosis, Caspase

3b-Hydroxy-5-cholenoic acid

Cat.No: T7628

Target: Endogenous Metabolite

Taurolithocholic acid sodium salt

Cat.No: T4727

Synonym: 牛磺石胆酸钠,Sodium taurolithocholate

Target: Others, Calcium Channel

Cat.No: T2963

Synonym: Cholanic acid,胆汁酸,Cholate,Colalin

Target: Endogenous Metabolite

Cat.No: T8207

Target: Others

12-Ketodeoxycholic acid

Cat.No: T14002

Target: Endogenous Metabolite

Dehydrocholic acid

Cat.No: T0408

Synonym: Dehystolin,Felacrinos,去氢胆酸,Sanocholen,Decholin

Target: Others

Isolithocholic Acid

Cat.No: T35792

Synonym: 3-Epilithocholic acid,3β-Hydroxy-5β-cholanic acid,β-Lithocholic acid,isoLCA

Target: Endogenous Metabolite

Glycocholic acid

Cat.No: T2831

Synonym: Glycocholate,甘氨胆酸,cholylglycine

Target: Others, Endogenous Metabolite

Norcholic Acid

Cat.No: T37177

Target: Others

Glycochenodeoxycholic Acid

Cat.No: T4588

Synonym: 甘氨鹅脱氧胆酸,Glycine chenodeoxycholate,Chenodeoxycholylglycine,GCDCA,Glycochenodeoxycholate,Lithocholylglycine

Target: Apoptosis, Endogenous Metabolite

Cat.No: T8294

Synonym: 万寿菊苷,槲皮万寿菊素-7-O-Β-吡喃葡萄糖苷,Quercetagetin-7-O-glucoside

Target: Others

Glycocholic Acid Sodium Salt

Cat.No: T4070

Synonym: Glycocholate Sodium,Sodium Glycocholate,甘氨胆酸钠盐

Target: Others

Glycochenodeoxycholic acid sodium salt

Cat.No: T5259

Synonym: GCDCA,甘氨鹅脱氧胆酸钠,Sodium glycochenodeoxycholate

Target: Apoptosis, Others, Endogenous Metabolite

Sodium taurocholate

Cat.No: TWA2417

Synonym: 牛黄胆酸钠(牛胆酸钠，牛胆酸钠盐，牛磺膽酸鈉，牛磺胆酸钠，牛磺胆酸钠盐，牛胆酸钠水合物，水合牛磺胆酸钠，牛胆酸钠(混合物)，牛黄胆酸钠(水合)，牛磺胆酸钠(标准品)),Taurocholate Sodium

Target: Others

Taurocholic acid

Cat.No: TN2259

Synonym: N-Choloyltaurine

Target: TNF, PI3K

Tauroursodeoxycholate

Cat.No: T2532

Synonym: Taurolite,牛磺熊去氧胆酸,Tauroursodeoxycholic Acid,UR 906,Ursodeoxycholyltaurine,TUDCA

Target: Apoptosis, ERK, P450, Caspase, Endogenous Metabolite

3β-Ursodeoxycholic acid

Cat.No: T13506

Synonym: Isoursodeoxycholic acid

Taurocholic acid sodium salt hydrate

Cat.No: T1138

Synonym: 牛胆酸钠,牛磺胆酸钠水合物,Sodium taurocholate hydrate,Taurocholic Acid sodium hydrate

Target: Others, Potassium Channel, Endogenous Metabolite

Lithocholic acid

Cat.No: T2202

Synonym: 3α-Hydroxy-5β-cholanic acid,石胆酸

Target: Apoptosis, Others, FXR, Endogenous Metabolite, Autophagy

Taurodeoxycholic acid

Cat.No: T75319

Synonym: Taurodeoxychloic acid

Target: Apoptosis, Calcium Channel, Caspase

Chenodeoxycholic acid

Cat.No: T0847

Synonym: CDCA,鹅去氧胆酸,Chenodiol

Target: Potassium Channel, FXR, Endogenous Metabolite, Autophagy

Glycodeoxycholate Sodium

Cat.No: T5254

Synonym: Sodium glycyldeoxycholate,Sodium glycodeoxycholate,Glycodeoxycholic acid sodium salt,脱氧甘胆酸钠

Target: Others, Endogenous Metabolite

Erythromycin estolate

Cat.No: T15245

Synonym: Phtalic anhydride,ilosone

Target: Antibacterial

Polyporusterone B

Cat.No: TN6909

Synonym: 猪苓酮B,(1R,2R,4S,5R,7R,11R,14S,15R)-14-[(2R,3R)-2,3-dihydroxy-6-methyl-5-methylideneheptan-2-yl]-4,5,11-trihydroxy-2,15-dimethyltetracyclo[8.7.0.02,?.011,1?]heptadec-9-en-8-one

Target: Others

Isodeoxycholic Acid

Cat.No: T36585

Synonym: isoDCA

Target: Chloride channel, Antibacterial

α-Muricholic acid

Cat.No: T19623

Target: AChR

ω-Muricholic Acid

Cat.No: T40790

Target: Others

Tauro-β-muricholic acid

Cat.No: T81030

Synonym: TβMCA

Target: FXR

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Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPH-03342	GBA2 Protein, Rat, Recombinant (His) Bile acid glucosyl transferase GBA2,Glucos...	Rat	E. coli
	GBA2 Protein, Rat, Recombinant (His) is expressed in E. coli expression system with C-6xHis tag. The predicted molecular weight is 42.6 kDa and the accession number is Q5M868.
TMPJ-00529	FABP6 Protein, Human, Recombinant (His) Ileal Lipid-Binding Protein,I-BABP,Intestinal Bile ...	Human	E. coli
	Fatty Acid-Binding Protein 6 (FABP6) is cytoplasmic protein that binds long-chain fatty acids and other hydrophobic ligands which belongs to the calycin superfamily. FABP6 expression is restricted in the small intestine to the ileum where it is involved in the enterohepatic circulation of bile acids. FABP6 forms a beta-barrel structure that accommodates the hydrophobic ligand in its interior. Isoform 2 is expressed in colorectal adenocarcinomas and their adjacent normal mucosa (at protein level)...
TMPJ-00207	AKR1C2 Protein, Human, Recombinant 3-Alpha-HSD3,Chlordecone Reductase Homolog HAKRD,2-Diol Dehy...	Human	E. coli
	Aldo-Keto Reductase Family 1 Member C2 (AKR1C2) plays a role in concert with the 5-α/5-β-Steroid Reductases to convert Steroid hormones into the 3-α/5-α and 3-α/5-β-Tetrahydrosteroids. AKR1C2 catalyzes the inactivation of the most potent androgen 5-α-Dihydrotestosterone (5-α-DHT) to 5-α-Androstane-3-α, 17-β-diol (3-α-diol).
TMPY-02907	FGF-19 Protein, Human, Recombinant fibroblast growth factor 19,FGF19	Human	E. coli
	FGF19, also known as FGF-19, is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. FGF19 interacts with FGFR1, FGFR2, FGFR3 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by KL, KLB and heparan sulfate glycosaminoglyca...
TMPH-02652	FGF-15 Protein, Mouse, Recombinant (His & SUMO) Fibroblast growth factor 15,Fgf15	Mouse	E. coli
	Involved in the suppression of bile acid biosynthesis through down-regulation of CYP7A1 expression.
TMPY-02249	FABP6 Protein, Human, Recombinant I-BABP,I-BAP,ILLBP,I-15P,ILBP3,I-BALB,ILBP,fatty acid	Human	E. coli
	Gastrotropin, also known as Fatty acid-binding protein 6, Ileal lipid-binding protein, ILBP, Intestinal 15 kDa protein, Intestinal bile acid-binding protein, I-BABP and FABP6, is a cytoplasm protein which belongs to thecalycin superfamily and Fatty-acid binding protein (FABP) family. Isoform2 of FABP6 is expressed in colorectal adenocarcinomas and their adjacent normal mucosa (at protein level). Isoform1of FABP6 is expressed in the jejunum, ileum, cecum and ascending colon intestine. Isof...
TMPH-02681	GPX7 Protein, Mouse, Recombinant (His & Myc) Glutathione peroxidase 7,Gpx7	Mouse	E. coli
	It protects esophageal epithelia from hydrogen peroxide-induced oxidative stress. It suppresses acidic bile acid-induced reactive oxigen species (ROS) and protects against oxidative DNA damage and double-strand breaks. GPX7 Protein, Mouse, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 26.7 kDa and the accession number is Q99LJ6.
TMPH-00721	YgiS Protein, E. coli, Recombinant (His & SUMO) Probable deoxycholate-binding periplasmic protein YgiS,ygiS	E. coli	E. coli
	Probably part of a deoxycholate transport system. Its expression in the presence of deoxycholate in a ygiS deletion mutant increases intracellular deoxycholate levels and decreases cell growth; higher expression in the presence of deoxycholate inhibits cell growth completely. Bile acid detergents such as deoxycholate are important for host defense against bacterial growth in the gall bladder and duodenum.
TMPY-00481	AKR1C4 Protein, Human, Recombinant (His) aldo-keto reductase family 1, member C4,3-alpha-HSD,DD4,CHDR...	Human	E. coli
	Aldo-keto reductases comprise of AKR1C1-AKR1C4, four enzymes that catalyze NADPH dependent reductions and have been implicated in biosynthesis, intermediary metabolism, and detoxification. there is a strong correlation between the expression levels of these family members and the malignant transformation as well as the resistance to cancer therapy. Type I human hepatic 3alpha-hydroxysteroid dehydrogenase (AKR1C4) plays a significant role in bile acid biosynthesis, steroid hormone metabolism, an...
TMPY-01878	L-FABP Protein, Human, Recombinant (His) fatty acid binding protein 1, liver,FABPL,L-FABP	Human	E. coli
	Fatty acid-binding protein, liver, also known as Fatty acid-binding protein 1, Liver-type fatty acid-binding protein, FABP1 and FABPL,is a cytoplasm protein which belongs to thecalycin superfamily and Fatty-acid binding protein (FABP) family. Fatty acid binding proteins are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands. FABP1 and FABP6 (the ileal fatty acid binding protein) are also able to bind bile acids. It is t...
TMPY-03497	AKR1C2 Protein, Human, Recombinant (His) AKR1C2,HBAB,SRXY8,AKR1C-pseudo,aldo-keto reductase family 1,...	Human	E. coli
	AKR1C2 is a member of the aldo/keto reductase superfamily, which consists of more than 4 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols using NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme binds bile acid with high affinity, and shows minimal 3-alpha-hydroxysteroid dehydrogenase activity. AKR1C2 gene shares high sequence identity with three other gene ...
TMPJ-00715	FGF-19 Protein, Human, Recombinant (His) FGF-19,Fibroblast growth factor 19,FGF19	Human	E. coli
	Fibroblast growth factor 19 (FGF19) is a secreted protein which belongs to the FGFs family. FGF19 is expressed in fetal brain, cartilage, retina, and adult gall bladder. FGFs modulate cellular activity via at least 5 distinct subfamilies of high-affinity FGF receptors (FGFRs): FGFR-1, -2, -3, and -4, all with intrinsic tyrosine kinase activity. FGFRs can be important for regulation of glucose and lipid homeostasis. FGF19 has important roles as a hormone produced in the ileum in response to bile ...
TMPY-04813	ACAT2 Protein, Rat, Recombinant (His) acetyl-CoA acetyltransferase 2	Rat	E. coli
	Acyl-coenzyme A: cholesterol acyltransferase (ACAT) is an intracellular enzyme that produces cholesteryl esters in various tissues. In mammals, two ACAT genes (ACAT1 and ACAT2) have been identified. Together, these two enzymes are involved in storing cholesteryl esters as lipid droplets, in macrophage foam-cell formation, in absorbing dietary cholesterol, and in supplying cholesteryl esters as part of the core lipid for lipoprotein synthesis and assembly. The key difference in tissue distributio...

重组蛋白

GBA2 Protein, Rat, Recombinant (His)

Cat.No: TMPH-03342

Species: Rat

Expression System: E. coli

FABP6 Protein, Human, Recombinant (His)

Cat.No: TMPJ-00529

Species: Human

Expression System: E. coli

AKR1C2 Protein, Human, Recombinant

Cat.No: TMPJ-00207

Species: Human

Expression System: E. coli

FGF-19 Protein, Human, Recombinant

Cat.No: TMPY-02907

Species: Human

Expression System: E. coli

FGF-15 Protein, Mouse, Recombinant (His & SUMO)

Cat.No: TMPH-02652

Species: Mouse

Expression System: E. coli

FABP6 Protein, Human, Recombinant

Cat.No: TMPY-02249

Species: Human

Expression System: E. coli

GPX7 Protein, Mouse, Recombinant (His & Myc)

Cat.No: TMPH-02681

Species: Mouse

Expression System: E. coli

YgiS Protein, E. coli, Recombinant (His & SUMO)

Cat.No: TMPH-00721

Species: E. coli

Expression System: E. coli

AKR1C4 Protein, Human, Recombinant (His)

Cat.No: TMPY-00481

Species: Human

Expression System: E. coli

L-FABP Protein, Human, Recombinant (His)

Cat.No: TMPY-01878

Species: Human

Expression System: E. coli

AKR1C2 Protein, Human, Recombinant (His)

Cat.No: TMPY-03497

Species: Human

Expression System: E. coli

FGF-19 Protein, Human, Recombinant (His)

Cat.No: TMPJ-00715

Species: Human

Expression System: E. coli

ACAT2 Protein, Rat, Recombinant (His)

Cat.No: TMPY-04813

Species: Rat

Expression System: E. coli

Cat. No.	Product Name	Target	Signaling Pathways
TMIH-0257	Glycoursodeoxycholic Acid-d4
	Glycoursodeoxycholic Acid-d4 是 Glycoursodeoxycholic Acid 的氘代化合物。Glycoursodeoxycholic Acid 的 CAS 号为 64480-66-6。Glycoursodeoxycholic acid 是一种酰基甘氨酸和胆汁酸-甘氨酸缀合物，是熊去氧胆酸的代谢物。
TMID-0058	Glycocholic acid-d4
	Glycocholic acid-d4 是 Glycocholic acid 的氘代化合物。Glycocholic acid 的 CAS 号为 475-31-0。Glycocholic acid 是一种胆汁酸，具有抗肿瘤活性，能够靶向作用于耐药泵和非耐药泵通路。
TMIJ-0332	Taurolithocholic Acid-d5 Sodium Salt (Major)
	Taurolithocholic Acid-d5 Sodium Salt (Major) 是 Taurolithocholic Acid Sodium Salt 的氘代化合物。Taurolithocholic Acid Sodium Salt 的 CAS 号为 6042-32-6。Taurolithocholic acid sodium salt 是抑胆剂和Ca2+激动剂，可抑制放射性配体与毒蕈碱 M1 结合。
TMIH-0552	Tauroursodeoxycholic Acid-d4 Sodium Salt
	Tauroursodeoxycholic Acid-d4 Sodium Salt 是 Tauroursodeoxycholic Acid Sodium Salt 的氘代化合物。Tauroursodeoxycholic Acid Sodium Salt 的 CAS 号为 14605-22-2。Tauroursodeoxycholate，又称 ursodoxicoltaurine，是一种高度亲水性的三级胆汁酸，在人体内以低浓度产生。Tauroursodeoxycholate 是 ursodeoxycholic acid 更亲水的形式，而 ursodeoxycholic acid 是人类体内自然产生的更丰富的胆汁酸。Tauroursodeoxycholate 正在研究用于几种疾病，如原发性胆汁性肝硬化(PBC)、胰岛素抵抗、淀粉样变性、囊性纤维化、胆汁淤滞和肌萎缩性侧索硬化症。
TMIJ-0197	Tauroursodeoxycholic-2,2,3,4,4-d5 Acid
	Tauroursodeoxycholic-2,2,3,4,4-d5 Acid 是 Tauroursodeoxycholic Acid 的氘代化合物。Tauroursodeoxycholic Acid 的 CAS 号为 14605-22-2。Tauroursodeoxycholate，又称 ursodoxicoltaurine，是一种高度亲水性的三级胆汁酸，在人体内以低浓度产生。Tauroursodeoxycholate 是 ursodeoxycholic acid 更亲水的形式，而 ursodeoxycholic acid 是人类体内自然产生的更丰富的胆汁酸。Tauroursodeoxycholate 正在研究用于几种疾病，如原发性胆汁性肝硬化(PBC)、胰岛素抵抗、淀粉样变性、囊性纤维化、胆汁淤滞和肌萎缩性侧索硬化症。
TMIJ-0199	Tauroursodeoxycholic-d4 Acid Tauroursodiol-d4
	Tauroursodeoxycholic-d4 Acid 是 Tauroursodeoxycholic Acid 的氘代化合物。Tauroursodeoxycholic Acid 的 CAS 号为 14605-22-2。Tauroursodeoxycholate，又称 ursodoxicoltaurine，是一种高度亲水性的三级胆汁酸，在人体内以低浓度产生。Tauroursodeoxycholate 是 ursodeoxycholic acid 更亲水的形式，而 ursodeoxycholic acid 是人类体内自然产生的更丰富的胆汁酸。Tauroursodeoxycholate 正在研究用于几种疾病，如原发性胆汁性肝硬化(PBC)、胰岛素抵抗、淀粉样变性、囊性纤维化、胆汁淤滞和肌萎缩性侧索硬化症。
TMIJ-0304	Lithocholic Acid-d4
	Lithocholic Acid-d4 是 Lithocholic Acid 的氘代化合物。Lithocholic Acid 的 CAS 号为 434-13-9。Lithocholic acid是由鹅去氧胆酸盐通过细菌作用形成的胆汁酸，通常与甘氨酸或牛磺酸结合，被用作利胆剂。它作为清洁剂溶解脂肪以供吸收，并且本身被吸收。
TMID-0294	Taurodeoxycholic Acid-d4 Sodium Salt
	Taurodeoxycholic Acid-d4 Sodium Salt 是 Taurodeoxycholic Acid Sodium Salt 的氘代化合物。Taurodeoxycholic Acid Sodium Salt 的 CAS 号为 1180-95-6。Taurodeoxycholate sodium salt 是胆盐相关的阴离子洗涤剂，用于分离膜蛋白，包括线粒体内膜蛋白。它还可以抑制各种炎症反应。
TMID-0052	Taurocholic Acid-d4 Sodium
	Taurocholic Acid-d4 Sodium 是 Taurocholic Acid Sodium 的氘代化合物。Taurocholic Acid Sodium 的 CAS 号为 145-42-6。Sodium taurocholate hydrate 具有显著的生物学效应，例如通过上调 VEGF-A 的表达抑制肝动脉结扎所致的胆道损伤。对免疫系统具有一定的调节作用。
TMIJ-0198	Taurochenodeoxycholic Acid-d5 Sodium Salt
	Taurochenodeoxycholic Acid-d5 Sodium Salt 是 Taurochenodeoxycholic Acid Sodium Salt 的氘代化合物。Taurochenodeoxycholic Acid Sodium Salt 的 CAS 号为 6009-98-9。Taurochenodeoxycholic acid sodium 是动物胆汁酸的主要生物活性物质之一。它可诱导细胞凋亡，具有抗炎和免疫调节作用。
TMIH-0209	Elobixibat-d5
	Elobixibat-d5 是 Elobixibat 的氘代化合物。Elobixibat 的 CAS 号为 439087-18-0。Elobixibat 是回肠胆汁酸转运蛋白的抑制剂（小鼠、人和犬 IBAT 的 IC50：0.13 nM、0.53 nM 和 5.8 nM）。 Elobixibat 可用于慢性特发性便秘的研究。

同位素标记化合物

Glycoursodeoxycholic Acid-d4

Cat.No: TMIH-0257

Glycocholic acid-d4

Cat.No: TMID-0058

Taurolithocholic Acid-d5 Sodium Salt (Major)

Cat.No: TMIJ-0332

Tauroursodeoxycholic Acid-d4 Sodium Salt

Cat.No: TMIH-0552

Tauroursodeoxycholic-2,2,3,4,4-d5 Acid

Cat.No: TMIJ-0197

Tauroursodeoxycholic-d4 Acid

Cat.No: TMIJ-0199

Synonym: Tauroursodiol-d4

Lithocholic Acid-d4

Cat.No: TMIJ-0304

Taurodeoxycholic Acid-d4 Sodium Salt

Cat.No: TMID-0294

Taurocholic Acid-d4 Sodium

Cat.No: TMID-0052

Taurochenodeoxycholic Acid-d5 Sodium Salt

Cat.No: TMIJ-0198

Cat.No: TMIH-0209

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