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Search Results for " apoptosis induction "

Targets Recommended: FLT

155

抑制剂 & 化合物

35

天然产物

2

化合物库

24

重组蛋白

1

同位素标记化合物

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Cat. No.	Product Name
L5300	线粒体靶向库		812 compounds
	812 种具有潜在或确定线粒体靶向活性的化合物，以促进针对线粒体的药物研究；
L2140	癌细胞分化化合物库		406 compounds
	406 个诱导肿瘤细胞分化化合物的独特集合，可用于高通量筛选和高内涵筛选；

化合物库

线粒体靶向库

Cat.No: L5300

Compounds: 812

癌细胞分化化合物库

Cat.No: L2140

Compounds: 406

Cat. No.	Product Name	Target	Signaling Pathways
T2051	SKLB4771 FLT3-IN-1,FLT3-IN-1	FLT	Angiogenesis; Tyrosine Kinase/Adaptors
	SKLB4771 (FLT3-IN-1) 是一种新型的、高效的 Flt3 抑制剂 (IC50:10nM)。
T11209	EOAI3402143	DUB	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Ubiquitination
	EOAI3402143 是一种去泛素化酶抑制剂，以剂量依赖性抑制 Usp9x/Usp24和 Usp5，增加肿瘤细胞凋亡。
T1535	Sodium 4-phenylbutyrate 苯丁酸钠,Sodium Phenylbutyrate,Buphenyl,4-苯基丁酸钠盐,TriButyrate	Apoptosis; HDAC; Autophagy	Apoptosis; Autophagy; Chromatin/Epigenetic; DNA Damage/DNA Repair
	Sodium 4-phenylbutyrate (TriButyrate) 是一种组蛋白去乙酰化酶和内质网应激抑制剂，可研究癌症和感染等疾病。
T21017	5'-Amino-5'-deoxyadenosine 5' Amino 5' deoxyadenosine,5'Amino5'deoxyadenosine,Nsc 238990,NH2dAdo	Apoptosis; Adenosine Receptor	Apoptosis; GPCR/G Protein; Neuroscience
	5'-Amino-5'-deoxyadenosine (NH2dAdo) 是一种针对惰性淋巴系统恶性肿瘤的腺苷激酶抑制剂，具有抗肿瘤和抗癌作用。5'-Amino-5'-deoxyadenosine 的抗癌机制通过抑制 DNA 合成，诱导细胞凋亡 (apoptosis) 等来实现。
T6017	Linsitinib OSI-906,林西替尼	IGF-1R	Tyrosine Kinase/Adaptors
	Linsitinib (OSI-906) 是选择性的、有效的、具有口服活性的IGF-1和胰岛素受体(IR)的双重抑制剂，IC50分别为 35 和 75 nM。
T6891	MK-4101	Apoptosis; Hedgehog/Smoothened; Smo	Apoptosis; GPCR/G Protein; Stem Cells
	MK-4101 是一种 SMO 拮抗剂，对 293 细胞的 IC50为 1.1 µM。它也是一种 hedgehog 信号通路的有效抑制剂，对小鼠细胞和KYSE180 食管癌细胞的IC50分别为 1.5 µM 和 1 µM。它能抗肿瘤，抑制肿瘤细胞增殖并诱导细胞凋亡。
T35528L	TD52 dihydrochloride TD52 dihydrochloride(1798328-24-1 Free base),TD52 2HCl	Others	Others
	TD52 dihydrochloride (TD52 2HCl), a derivative of Erlotinib, is a potent and orally active inhibitor of protein phosphatase 2A (CIP2A). It exhibits strong anti-cancer properties by regulating the CIP2A/PP2A/p-Akt signaling pathway, resulting in the induction of apoptosis in triple-negative breast cancer (TNBC) cells. Mechanistically, TD52 dihydrochloride disrupts the binding of Elk1 to the CIP2A promoter, effectively reducing CIP2A levels. Notably, TD52 dihydrochloride demonstrates powerful anti...
T8969	API-1 NSC177223	Akt	Cytoskeletal Signaling; PI3K/Akt/mTOR signaling
	API-1 (NSC-177223) 是Akt/PKB 抑制剂，可同 PH 结构域相结合并抑制 Akt 膜易位，有效降低 Akt 的磷酸化水平。它可选择性的抑制PKB，对 PKC 和 PKA 的激活无抑制作用。它可以和 TNF 相关的凋亡诱导配体协同作用从而诱导细胞凋亡。
T1608	ADH-1 trifluoroacetate Exherin trifluoroacetate	Dehydrogenase	Metabolism
	ADH-1 trifluoroacetate (Exherin trifluoroacetate) 是一种选择性的、竞争性N-钙粘蛋白拮抗剂，具有潜在抗肿瘤和抗血管生成作用。
T10352	APTO-253 LOR-253,LT-253	Apoptosis; c-Myc; KLF	Apoptosis; Cell Cycle/Checkpoint; MAPK
	APTO-253 (LOR-253) 抑制 c-Myc 表达，稳定 G-四链体 DNA，并诱导急性髓细胞白血病细胞的细胞周期停滞和凋亡。它通过诱导 KLF4 肿瘤抑制因子介导抗癌活性，具有抗关节炎活性。
T3351	Onatasertib CC223,CC 223,CC-223	Apoptosis; c-Fms; DNA-PK; FLT; PI3K; mTOR	Angiogenesis; Apoptosis; DNA Damage/DNA Repair; PI3K/Akt/mTOR signaling; Tyrosine Kinase/Adaptors
	Onatasertib (CC223) 是一种口服有效的mTOR 激酶抑制剂，抑制mTOR 激酶，IC50为 16 nM。它抑制mTORC1和mTORC2。
TNU0630	2'-O-Methyl-5-iodouridine 5-Iodo-2'-O-methyluridine	Others	Others
	2'-O-Methyl-5-iodouridine (5-Iodo-2'-O-methyluridine) 是一种靶向惰性淋巴系统恶性肿瘤的嘌呤核苷类似物，具有广泛的抗肿瘤活性。2'-O-Methyl-5-iodouridine 的抗癌机制依赖于抑制 DNA 合成，诱导细胞凋亡 (apoptosis) 。
T1849	Momelotinib CYT11387,CYT387,LM-1149	Apoptosis; JAK; Autophagy	Angiogenesis; Apoptosis; Autophagy; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells
	Momelotinib (LM-1149) 是一种 ATP 竞争性的 JAK1/JAK2抑制剂，IC50值分别为 11 nM/18 nM。
T3124	Carbendazim Bavistin,Carbendazole,多菌灵,Mercarzole	Antifungal	Microbiology/Virology
	Carbendazim (Mercarzole) 是一种具有抗肿瘤活性的苯并咪唑衍生物，可用于癌症研究。它是一种口服广谱苯并咪唑杀菌剂，可作为真菌疾病研究的杀虫剂。
T3352	XL413	cholecystokinin; Casein Kinase; Pim; CDK	Cell Cycle/Checkpoint; Chromatin/Epigenetic; GPCR/G Protein; JAK/STAT signaling; Metabolism; Stem Cells
	XL413 是一种口服生物可利用的细胞分裂周期 7 同源物 (CDC7) 激酶抑制剂，具有潜在的抗肿瘤活性，IC50值为 3.4 nM。它对 pMCM 的 EC50值为 118 nM，对 CK2 和 PIM1 的 IC50值分别为 215 和 42 nM。
T19965	Dacomitinib hydrate PF 299804,:达克替尼一水合物,PF00299804,PF 00299804,PF-00299804,PF299804,PF-299804	EGFR	Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	Dacomitinib hydrate (PF 299804) 是泛表皮生长因子受体家族酪氨酸激酶的高选择性第二代小分子抑制剂。 Dacomitinib 特异性且不可逆地结合并抑制人 EGFR 亚型，从而抑制表达 EGFR 的肿瘤细胞的增殖和诱导细胞凋亡。
T68405	KW-2450 free base	IGF-1R	Tyrosine Kinase/Adaptors
	KW-2450 free base 是一种 IGF-1R/IR和酪氨酸激酶多重抑制剂具有抗肿瘤活性。KW-2450 free base 在小鼠 HT-29/GFP 结肠癌异种移植模型中显示出适度的生长抑制活性并抑制 IGF-1 诱导的信号转导。
T3637	Pifithrin-β hydrobromide Cyclic PFT-α,PFT-β,Cyclic Pifithrin-α hydrobromide,Pifithrin-β,PFT β (hydrobromide)	Ferroptosis; p53	Apoptosis
	Pifithrin-β hydrobromide (Cyclic PFT-α) 是一种 p53 的抑制剂，可逆地阻断 p53 依赖性转录激活和细胞凋亡。IC50值为23 μM。
T33701	NM-3 NM-3,isocoumarin,NM 3,Isocoumarin NM-3,NM3	Apoptosis; Reactive Oxygen Species	Apoptosis; Immunology/Inflammation; Metabolism; NF-κB
	NM-3 是一种可口服的抗血管生成的抑制剂，具有抗肿瘤活性。NM-3在体外和体内可当作辐射调节剂使用。NM-3抑制血管内皮生长因子（VEGF），从而抑制内皮细胞的增殖。NM-3与活性氧的机制诱导细胞凋亡有关。
T3661	Citarinostat ACY241,HDAC-IN-2	HDAC	Chromatin/Epigenetic; DNA Damage/DNA Repair
	Citarinostat (ACY241) 是一种强效、选择性和口服组蛋白脱乙酰酶 (HDAC) 抑制剂，具有抗肿瘤活性，对 HDAC1、HDAC2、HDAC3、HDAC6 和 HDAC8 的 IC50分别为 35、45、46、2.6 和 137 nM。
T16328	Nitroaspirin 2-乙酰氧基苯甲酸-3-硝酸甲基苯酯,NCX 4016	Apoptosis; COX	Apoptosis; Immunology/Inflammation; Neuroscience
	Nitroaspirin (NCX 4016) 是一氧化氮供体和阿司匹林的硝基衍生物，与 Aspirin 结合可抑制环氧合酶=，可作为 COX-1 的直接和不可逆抑制剂。它通过下调 EGFR/PI3K/STAT3 信号传导和调节 Bcl-2 家族蛋白，显着诱导顺铂耐药人卵巢癌细胞的细胞周期停滞和凋亡，具有抗血栓和抗血小板特性。
T3157	COH29 RNR Inhibitor COH29	DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	COH29 (RNR Inhibitor COH29) 是一种口服可用的芳香族取代噻唑，是人类核糖核苷酸还原酶 (RNR) 的抑制剂，具有潜在的抗肿瘤活性。它抑制核糖核苷酸还原酶的IC50为 16 μM。
T36674	DMU-212	Apoptosis; ERK	Apoptosis; MAPK
	DMU-212 是具有口服活性的白藜芦醇的甲基化衍生物，表现出抗分裂、抗增殖、抗氧化和促进细胞凋亡的活性。它通过诱导凋亡和激活ERK1/2蛋白阻止有丝分裂。
T25275	Crambene NSC 321802,NSC-321802,NSC321802	Others	Others
	Crambene results in the induction of apoptosis by protects mice against acute pancreatitis via anti-inflammatory pathways.
TQ0016	NKP-1339 IT-139,KP-1339	DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	NKP-1339 (IT-139) induces G2/M cell cycle arrest, blockage of DNA synthesis, and induction of apoptosis via the mitochondrial pathway.
T19779	SL-01 Z L Phe chloromethyl ketone,NSC-251810,ZLPhe chloromethyl ketone,Z-Phe-chloromethylketone	Others	Others
	SL-01 is an oral derivative of gemcitabine. SL-01 inhibited human breast cancer growth through the induction of apoptosis. SL-01 inhibited human cancer growth more potently than gemcitabine.
T36083	DS-7423	PI3K; mTOR	PI3K/Akt/mTOR signaling
	DS-7423 是PI3K 和mTOR 的有效抑制剂，抑制PI3Kα 和 mTOR 的IC50分别为15.6 nM 和 34.9 nM。DS-7423表现出抗癌活性。
T40723	Bromoiodoacetamide	Others	Others
	Bromoiodoacetamide, an iodinated haloacetamide (I-HAcAm) compound, exhibits cytotoxic properties. Its mechanism of action involves the accumulation of reactive oxygen species (ROS) and induction of apoptosis in HepG-2 cells.
T21321	MK-0731	Others	Others
	MK-0731, a synthetic small molecule with potential antineoplastic activity, selectively inhibits kinesin spindle protein (KSP), leading to the inhibition of mitotic spindle assembly, induction of cell cycle arrest during the mitotic phase and apoptosis in
T71231	VMY-1-101	Others	Others
	VMY-1-101 is a synthesized fluorescent CDK inhibitor. VMY-1-101 demonstrates potent CDK inhibitory activity, enhanced induction of G2/M arrest and modest apoptosis as compared to purvalanol B.
T14554	BI-0252	Others	Others
	BI-0252 is an inhibitor of MDM2-p53 (IC50:4 nM). BI-0252 can induce tumor regressions in all animals of a mouse SJSA-1 xenograft. And it concomitant induction of the tumor protein p53 (TP53) target genes and markers of apoptosis.
T71034	Bizelesin	Others	Others
	Bizelesin is a synthetic cyclopropylpyrroloindole antineoplastic antibiotic. Bizelesin binds to the minor groove of DNA and induces interstrand cross-linking of DNA, thereby inhibiting DNA replication and RNA synthesis. Bizelesin also enhances p53 and p21 induction and triggers G2/M cell-cycle arrest, resulting in cell senescence without apoptosis.
T61137	VEGFR-2-IN-19	Others	Others
	VEGFR-2-IN-19 (Compound 15b) is a highly efficacious inhibitor of VEGFR2, a receptor involved in angiogenesis. Its mechanism of action involves the induction of cellular apoptosis and elevation of intracellular reactive oxygen species. Due to these properties, VEGFR-2-IN-19 holds promise as an effective anticancer agent [1].
T70152	Miransertib mesylate	Others	Others
	Miransertib mesylate is a selective AKT inhibitor that binds to and inhibits the activity of AKT in a non-ATP competitive manner, which may result in the inhibition of the PI3K/AKT signaling pathway. This may result in reduction in tumor cell proliferation and the induction of tumor cell apoptosis.
T36399	PAO-Nap
	PAO-Nap is a chemically modified version of PAO, in which a naphthalimide fluorophore is attached to the compound using a linker called aminocaproic acid. This modified compound, PAO-Nap, exhibits a selective targeting of thioredoxin reductase, leading to the induction of apoptosis in HL-60 cells through oxidative stress mechanisms[1].
T26817	Bim-BLK-A Bim Blocker A,Compound A,Bim BLK A,BimBLKA	Others	Others
	Bim-BLK-A efficiently blocks Bim-induced apoptosis after Bax is activated on the mitochondria. The cellular target of Bim-BLK-A was identified to be the succinate dehydrogenase subunit B (SDHB) protein of complex II of the mitochondrial electron transfer
T75036	N1-(2-Methyl)propyl pseudouridine	Others	Others
	N1-(2-Methyl)propyl pseudouridine 是一种具有广泛抗肿瘤活性的嘌呤核苷类似物，主要用于靶向惰性淋巴系统恶性肿瘤。其抗癌机制包括抑制 DNA 合成和诱导细胞凋亡（apoptosis）。
T75066	N1-Methylxylo-guanosine	Others	Others
	N1-Methylxylo-guanosine 为一种具备广泛抗肿瘤活性的嘌呤核苷类似物，主要针对惰性淋巴系统恶性肿瘤。其抗癌机制涉及抑制 DNA 合成与诱导细胞凋亡(apoptosis)。
T75211	Confidential-2	Others	Others
	Confidential-2 为嘌呤核苷类似物，具广泛抗肿瘤活性，靶向惰性淋巴系统恶性肿瘤。其抗癌机制通过抑制 DNA 合成及诱导细胞凋亡（apoptosis）实现。
T75212	Confiden	Others	Others
	Confiden 为一种嘌呤核苷类似物，广泛抗肿瘤活性，针对惰性淋巴系统恶性肿瘤。其抗癌机制通过抑制DNA合成及诱导细胞凋亡(apoptosis)实现。
T75218	3-Cyanovinyl-9-(5’-O-DMT-2’-deoxyribofuranosyl)carbazole	Others	Others
	3-Cyanovinyl-9-(5’-O-DMT-2’-deoxyribofuranosyl)carbazole 为一嘌呤核苷类似物，具备广泛抗肿瘤作用，主要针对惰性淋巴系统的恶性肿瘤。其抗癌机制主要通过抑制 DNA 合成和诱导细胞凋亡 (apoptosis) 实现。
T75037	N1-Methoxymethyl pseudouridine	Others	Others
	N1-Methoxymethyl pseudouridine 是一种嘌呤核苷类似物。嘌呤核苷类似物具有广泛的抗肿瘤活性，靶向惰性淋巴系统恶性肿瘤。这一过程中的抗癌机制依赖于抑制 DNA 合成，诱导细胞凋亡 (apoptosis) 等。
T75033	Adenosine-2-carboxy methyl amide	Others	Others
	Adenosine-2-carboxy methyl amide为一种嘌呤核苷类似物，其抗肿瘤活性广泛，尤其针对惰性淋巴系统恶性肿瘤。其作用机制主要通过抑制DNA合成及诱导细胞凋亡（apoptosis）实现。
T68536	WP-1034	Others	Others
	WP-1034 is a novel Jak-Stat inhibitor, which is active against AML blasts. WP-1034 effectively inhibited proliferation of OCIM2 cells and fresh AML samples. WP-1034 caused cell cycle arrest of OCIM2 cells in sub-Go phase. WP-1034 induced apoptosis of OCIM2 cells and that induction of apoptosis involved cleavage of caspase 3 and the DNA repair enzyme poly (adenosine diphosphate [ADP]-ribose) polymerase (PARP).
T61584	ASK1-IN-3	Others	Others
	ASK1-IN-3 is a highly potent and selective inhibitor of ASK1 kinase, demonstrating an IC 50 of 33.8 nM. This compound also exhibits inhibitory effects on various cell cycle regulating kinases. ASK1-IN-3 showcases remarkable induction of apoptosis in HepG2 cancer cells and displays potent activity in arresting the cell cycle [1].
T75053	3’-β-C-Methyl-2-thiouridine	Others	Others
	3’-β-C-Methyl-2-thiouridine 是一种具有广泛抗肿瘤活性的嘌呤核苷类似物，主要通过抑制DNA合成及诱导细胞凋亡（apoptosis）等机制，靶向惰性淋巴系统恶性肿瘤。
T75087	Uridine-5-oxo-acetyl-(9-fluorenylmethyl) ester	Others	Others
	Uridine-5-oxo-acetyl-(9-fluorenylmethyl) ester 为一种嘌呤核苷类似物，广泛显示出抗肿瘤活性，并针对惰性淋巴系统恶性肿瘤。其抗癌机制主要通过抑制DNA合成和诱导细胞凋亡(apoptosis)实现。
T12003	Mensacarcin	Others; ADC Cytotoxin	Antibody-drug Conjugate/ADC Related; Others
	Mensacarcin, a highly complex polyketide compound, exhibits multifaceted effects on cellular processes. Specifically, it targets mitochondria, perturbs energy metabolism within these organelles, and activates caspase-dependent apoptotic pathways. Functionally, Mensacarcin can serve as a cytotoxic constituent in antibody-drug conjugates (ADCs). Furthermore, this antibiotic compound displays broad-spectrum inhibition of cell growth across various cancer cell lines and demonstrates potent induction...
T75054	8-Chloro-2’-O-methyl inosine	Others	Others
	8-Chloro-2’-O-methyl inosine 是一种具有广泛抗肿瘤活性的嘌呤核苷类似物，特别是针对惰性淋巴系统恶性肿瘤。其抗癌机制主要通过抑制 DNA 合成和诱导细胞凋亡（apoptosis）来实现。
T75038	N1-Benzoyl pseudouridine	Others	Others
	N1-Benzoyl pseudouridine 是嘌呤核苷类似物，广泛应用于靶向惰性淋巴系统恶性肿瘤的抗肿瘤活性中。其抗癌机制主要通过抑制DNA合成和诱导细胞凋亡(apoptosis)实现。

化合物

Cat.No: T2051

Synonym: FLT3-IN-1,FLT3-IN-1

Target: FLT

Cat.No: T11209

Target: DUB

Sodium 4-phenylbutyrate

Cat.No: T1535

Synonym: 苯丁酸钠,Sodium Phenylbutyrate,Buphenyl,4-苯基丁酸钠盐,TriButyrate

Target: Apoptosis, HDAC, Autophagy

5'-Amino-5'-deoxyadenosine

Cat.No: T21017

Synonym: 5' Amino 5' deoxyadenosine,5'Amino5'deoxyadenosine,Nsc 238990,NH2dAdo

Target: Apoptosis, Adenosine Receptor

Cat.No: T6017

Synonym: OSI-906,林西替尼

Target: IGF-1R

Cat.No: T6891

Target: Apoptosis, Hedgehog/Smoothened, Smo

TD52 dihydrochloride

Cat.No: T35528L

Synonym: TD52 dihydrochloride(1798328-24-1 Free base),TD52 2HCl

Target: Others

Cat.No: T8969

Synonym: NSC177223

Target: Akt

ADH-1 trifluoroacetate

Cat.No: T1608

Synonym: Exherin trifluoroacetate

Target: Dehydrogenase

Cat.No: T10352

Synonym: LOR-253,LT-253

Target: Apoptosis, c-Myc, KLF

Cat.No: T3351

Synonym: CC223,CC 223,CC-223

Target: Apoptosis, c-Fms, DNA-PK, FLT, PI3K, mTOR

2'-O-Methyl-5-iodouridine

Cat.No: TNU0630

Synonym: 5-Iodo-2'-O-methyluridine

Target: Others

Cat.No: T1849

Synonym: CYT11387,CYT387,LM-1149

Target: Apoptosis, JAK, Autophagy

Cat.No: T3124

Synonym: Bavistin,Carbendazole,多菌灵,Mercarzole

Target: Antifungal

Cat.No: T3352

Target: cholecystokinin, Casein Kinase, Pim, CDK

Dacomitinib hydrate

Cat.No: T19965

Synonym: PF 299804,:达克替尼一水合物,PF00299804,PF 00299804,PF-00299804,PF299804,PF-299804

Target: EGFR

KW-2450 free base

Cat.No: T68405

Target: IGF-1R

Pifithrin-β hydrobromide

Cat.No: T3637

Synonym: Cyclic PFT-α,PFT-β,Cyclic Pifithrin-α hydrobromide,Pifithrin-β,PFT β (hydrobromide)

Target: Ferroptosis, p53

Cat.No: T33701

Synonym: NM-3,isocoumarin,NM 3,Isocoumarin NM-3,NM3

Target: Apoptosis, Reactive Oxygen Species

Cat.No: T3661

Synonym: ACY241,HDAC-IN-2

Target: HDAC

Cat.No: T16328

Synonym: 2-乙酰氧基苯甲酸-3-硝酸甲基苯酯,NCX 4016

Target: Apoptosis, COX

Cat.No: T3157

Synonym: RNR Inhibitor COH29

Target: DNA/RNA Synthesis

Cat.No: T36674

Target: Apoptosis, ERK

Cat.No: T25275

Synonym: NSC 321802,NSC-321802,NSC321802

Target: Others

Cat.No: TQ0016

Synonym: IT-139,KP-1339

Target: DNA/RNA Synthesis

Cat.No: T19779

Synonym: Z L Phe chloromethyl ketone,NSC-251810,ZLPhe chloromethyl ketone,Z-Phe-chloromethylketone

Target: Others

Cat.No: T36083

Target: PI3K, mTOR

Bromoiodoacetamide

Cat.No: T40723

Target: Others

Cat.No: T21321

Target: Others

Cat.No: T71231

Target: Others

Cat.No: T14554

Target: Others

Cat.No: T71034

Target: Others

Cat.No: T61137

Target: Others

Miransertib mesylate

Cat.No: T70152

Target: Others

Cat.No: T36399

Cat.No: T26817

Synonym: Bim Blocker A,Compound A,Bim BLK A,BimBLKA

Target: Others

N1-(2-Methyl)propyl pseudouridine

Cat.No: T75036

Target: Others

N1-Methylxylo-guanosine

Cat.No: T75066

Target: Others

Cat.No: T75211

Target: Others

Cat.No: T75212

Target: Others

3-Cyanovinyl-9-(5’-O-DMT-2’-deoxyribofuranosyl)carbazole

Cat.No: T75218

Target: Others

N1-Methoxymethyl pseudouridine

Cat.No: T75037

Target: Others

Adenosine-2-carboxy methyl amide

Cat.No: T75033

Target: Others

Cat.No: T68536

Target: Others

Cat.No: T61584

Target: Others

3’-β-C-Methyl-2-thiouridine

Cat.No: T75053

Target: Others

Uridine-5-oxo-acetyl-(9-fluorenylmethyl) ester

Cat.No: T75087

Target: Others

Cat.No: T12003

Target: Others, ADC Cytotoxin

8-Chloro-2’-O-methyl inosine

Cat.No: T75054

Target: Others

N1-Benzoyl pseudouridine

Cat.No: T75038

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T6S0234	Toosendanin	Others	Others
	Toosendanin 是一种从杜鹃花果实皮中提取的三萜，具有杀虫和抗炎活性，可用于研究缓解疼痛。
TJS0487	(-)-Syringaresinol DL-Syringaresinol,Lirioresinol b,(-)-丁香脂素	Others	Others
	(-)-Syringaresinol (DL-Syringaresinol) 来源于番荔枝 Annona Montana 的茎。 (-)-Syringaresinol 通过 G1 期阻滞和诱导细胞凋亡来抑制人早幼粒细胞 HL-60 细胞的增殖，并具有抗癌活性。
TMS0484	Episyringaresinol 4'-O-β-D-glncopyranoside (-)-丁香树脂酚-4-O-β-D-葡萄糖苷,(-)-Syringaresinol 4-O-β-D-glucopyranosi	Others	Others
	Episyringaresinol 4'-O-β-D-glncopyranoside ((-)-Syringaresinol 4-O-β-D-glucopyranosi) 是一种天然的潜在神经炎症抑制剂，分离自鼠尾草 (Alhagi sparsifoliaShap) 。
T2S0886	Terrestrosin D	Apoptosis; Others	Apoptosis; Others
	Terrestrosin D 是从刺蒺藜中提取得到一种的甾体皂苷，可诱导细胞周期阻滞和癌细胞凋亡，具有抗血管生成的活性。
TN1461	(-)-Butin Butin,漆黄素 ( 紫铆素)	Akt; PI3K; Nrf2	Cytoskeletal Signaling; Immunology/Inflammation; PI3K/Akt/mTOR signaling
	(-)-Butin (Butin) 是 Butin 的 S 对映体。其中 Butin 是一种分离自黄檀的心材中的生物活性黄酮类化合物，具有显著的抗血小板、抗氧化、抗炎作用。
T5S1607	Morusin Mulberrochromene,桑辛素	NF-κB; Antibacterial; STAT	JAK/STAT signaling; Microbiology/Virology; NF-κB; Stem Cells
	Morusin (Mulberrochromene) 是从M. australis 分离的去乙烯基化黄酮，可抑制NF-κB 和STAT3的活性，具有抗菌、抗肿瘤、抗氧化等各种生物活性。
T5S1285	(+)-(3R,8S)-Falcarindiol Falcarindiol,镰叶芹二醇	Others	Others
	(+)-(3R,8S)-Falcarindiol 是一种从胡萝卜中得到的聚乙炔，有抗炎、抗肿瘤和抗脂质过氧化活性。它具有抗分歧杆菌作用，对Mycobacterium tuberculosisH37Ra 的 MIC 和 IC50值分别为 24 μM 和 6 μM。
T3S1227	Aristolactam I Aristolactam,Aristololactam I,马兜铃内酰胺I,Aristololactum	Apoptosis; Caspase	Apoptosis; Proteases/Proteasome
	Aristolactam I (Aristololactum) 是马兜铃酸 I (AA-I) 的主要代谢产物，参与导致肾损伤的过程。它具有细胞毒性，通过诱导半胱天冬酶 3 依赖性途径中的细胞凋亡介导。
TN1804	Isosilybin A 异水飞蓟素 A,异水飞蓟宾A,水飞蓟素 B2	Apoptosis; Tyrosinase; PPAR; ABC	Apoptosis; DNA Damage/DNA Repair; Membrane transporter/Ion channel; Metabolism; Proteases/Proteasome
	Isosilybin A 是从水飞蓟中分离出来的一种黄酮木脂素，可抑制癌细胞增殖并诱导 G1 期停滞和凋亡，通过靶向 Akt-NF-κB-雄激素受体轴激活前列腺癌细胞的凋亡机制，具有抗前列腺癌活性。
T3S0081	Oxypeucedanin (+-)-Oxypeucedanin,氧化前胡素,Oxypeucadanin	Potassium Channel	Membrane transporter/Ion channel
	Oxypeucedanin ((+-)-Oxypeucedanin) 是呋喃香豆素衍生物，分离自Angelica dahurica。它是选择性开放通道阻滞剂，可抑制hKv1.5通道电流，IC50值为 76 nM。它延长心脏动作电位持续时间，是潜在的抗心律失常试剂。它通过抑制癌细胞迁移来诱导细胞凋亡。
TWS2045	Bruceine D 鸦胆子素D,鸦胆子苦素D	Apoptosis; Antiviral; Gamma-secretase; Parasite	Apoptosis; Immunology/Inflammation; Microbiology/Virology; Neuroscience; Proteases/Proteasome; Stem Cells
	Bruceine D 是Notch 抑制剂，有抗癌活性，诱导几种人癌细胞调亡。它是一种有效的植物性昆虫拒食剂，有显著的系统特性和抑制害虫生长的作用。它具有较强的驱虫活性，抑制D. intermedius 的 EC50值为 0.57 mg/L。
T6S2391	L-Chicoric Acid (-)-Chicoric acid,trans-Caffeoyltartaric acid,Chicoric acid,L-菊苣酸,dicaffeoyltartaric acid,菊苣酸	Others; HIV Protease	Microbiology/Virology; Others; Proteases/Proteasome
	L-Chicoric Acid (trans-Caffeoyltartaric acid) 是一种二咖啡酰酒石酸，是一种选择性可逆的 HIV-1 整合酶抑制剂，IC50约为 100 nM。它还可抑制 HIV-1 复制。
T4S2126	Ginkgetin 银杏双黄酮,银杏素	Apoptosis; Wnt/beta-catenin; COX; STAT; Autophagy	Apoptosis; Autophagy; Cytoskeletal Signaling; Immunology/Inflammation; JAK/STAT signaling; Neuroscience; Stem Cells
	Ginkgetin 是从银杏叶中分离得到的一种双黄酮，具有抗肿瘤、抗炎、神经保护、抗真菌的作用。它也是 Wnt 信号抑制剂，IC50值为 5.92 μM。
T6S0525	Farrerol	ERK; p38 MAPK; Akt	Cytoskeletal Signaling; MAPK; PI3K/Akt/mTOR signaling
	Farrerol 是一种杜鹃花的生物活性成分，具有抗氧化、抗肿瘤、抗炎、神经保护和肝保护等多种功能。
T3877	Esculentoside A	NF-κB; COX	Immunology/Inflammation; Neuroscience; NF-κB
	Esculentoside A 是一种三萜皂苷，从商陆根部分离得到。它在具有抗炎活性，对环氧合酶-2 具有选择性抑制活性。它通过抑制NF-κB 和丝裂原活化蛋白激酶信号通路抑制 LPS 诱导的急性肺损伤中的炎症反应。
T5S2343	Acetylshikonin 乙酰紫草素,Acetyl shikonin	Others; P450; AChE	Metabolism; Neuroscience; Others
	Acetylshikonin 来源于紫草根，具有抗癌、抗炎作用。它是一种 AChE 抑制剂，具有很强的抗凋亡活性。它是一种非选择性的细胞色素 P450抑制剂，对所有 P450 亚型抑制的 IC50值范围为 1.4-4.0 μM。
T3S0027	Picropodophyllotoxin AXL 1717,Picropodophyllin,苦鬼臼毒素	IGF-1R	Tyrosine Kinase/Adaptors
	Picropodophyllotoxin (AXL 1717) 是一种环木脂素生物碱，存在于五月树(Podophyllum peltatum) 中，是一种具有潜在抗肿瘤活性的胰岛素样生长因子 1 受体 (IGF1R) 的小分子抑制剂。它特异性抑制 IGF1R 的活性并下调细胞表达，而不干扰其他生长因子受体的活性，例如胰岛素受体、表皮生长因子、血小板衍生生长因子、成纤维细胞生长因子和肥大/干细胞生长因子 (KIT) ）。该药剂在抑制肿瘤细胞增殖和诱导肿瘤细胞凋亡方面显示出有效的活性。 IGF1R 是一种在多种人类癌症中过度表达的受体酪氨酸激酶，在多种癌细胞的生长和存活中起关键作用。
TN2400	alpha-Terthienylmethanol	Others	Others
	Alpha-terthienylmethanol possesses potent cytotoxic activity against human endometrial cancer cells; it inhibits growth mediated by the induction of apoptosis, as shown by the accumulation of sub-G1 and apoptotic cells.
TN3937	ent-16alpha,17-Dihydroxyatisan-3-one	P-gp	Membrane transporter/Ion channel; Neuroscience
	ent-16alpha,17-Dihydroxyatisan-3-one and ent-16alpha,17-dihydroxykauran-3-one have apoptosis induction activities on L5178 human MDR1 gene-transfected mouse lymphoma cells.
TN1572	Desacetylcinobufotalin	Others	Others
	Desacetylcinobufotalin has significant antitumor activity through induction apoptosis via mitochondria pathway, it also shows potent cytotoxic activities against HL-60 cell lines.
T13764	Lycopodine	Lipoxygenase; Caspase	Apoptosis; Metabolism; Proteases/Proteasome
	Lycopodine, a bioactive compound derived from Lycopodium clavatum spores, effectively inhibits the proliferation of HeLa cells through the induction of apoptosis. This process is mediated by caspase-3 activation. In refractory prostate cancer cells, Lycopodine triggers apoptosis by modulating 5-lipoxygenase and depolarizing the mitochondrial membrane potential, without altering p53 activity.
TN1442	Betulinic acid methyl ester	Antifection	Microbiology/Virology
	Betulinic acid methyl ester showed antiplasmodial activity against chloroquine-resistant Plasmodium falciparum parasites in vitro.It also inhibited B16 2F2 cell proliferation by induction of apoptosis.
TN4132	Germanicol
	Germanicol induces selective growth inhibitory effects in human colon HCT-116 and HT29 cancer cells through induction of apoptosis, cell cycle arrest and inhibition of cell migration. Germanicol may have anti-inflammatory effects .
TN1211	2-Hydroxy-3-methylanthraquinone	ERK; p38 MAPK; Caspase	Apoptosis; MAPK; Proteases/Proteasome
	2-Hydroxy-3-methylanthraquinone enhances apoptosis of U937 cells,in part,through activation of p-p38MAPK and downregulation of p-ERK1/2; triggers caspase-3 activation mediated apoptotic induction.
T11201	Enniatin A1 恩镰孢菌素 A1	ERK	MAPK
	Enniatin A1 possesses anticarcinogenic properties by induction of apoptosis and disruption of ERK signalling pathway. Enniatin A1 inhibits ACAT with an IC50 of 49 μM in rat liver microsomes. Enniatin A1 isolated from Fusarium mycotoxins is a cyclic hexadepsipeptide consisting of alternating D-α-hydroxyisovaleric acids and N-methyl-L-amino acids.
TN5050	Sprengerinin C	NADPH-oxidase; VEGFR; p38 MAPK; ROS; Akt; PI3K; mTOR; p53	Angiogenesis; Apoptosis; Cytoskeletal Signaling; Immunology/Inflammation; MAPK; PI3K/Akt/mTOR signaling; Tyrosine Kinase/Adaptors
	Sprengerinin C exerts anti-tumorigenic effects in hepatocellular carcinoma via inhibition of proliferation and angiogenesis and induction of apoptosis, it can strongly suppress tumor angiogenesis in human umbilical vein endothelial cells, it blocks vascul
T75704	Isoharringtonine	Others	Others
	Isoharringtonine，一种从Cephalotaxus koreanaNakai 纯化得到的天然生物碱，具有抑制癌细胞增殖和迁移的能力，同时能诱导癌细胞(apoptosis)。该化合物在癌症研究中应用。
TN2529	1-Decarboxy-3-oxo-ceanothic acid	DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	1-Decarboxy-3-oxo-ceanothic acid shows in vitro cytotoxic activity in a human ovarian adenocarcinoma cell line, the cytotoxic effect is mediated, at least in part, by the induction of apoptosis. It shows cytotoxic against OVCAR-3 and HeLa cancer cell line
T72802	Spongionellol A	Others	Others
	Spongionellol A 是一种 MDR1(p-糖蛋白) 抑制剂。Spongionellol A 通过诱导 caspase 依赖性的凋亡 (apoptosis) 而对前列腺癌细胞具有较强的细胞毒活性和选择性。Spongionellol A 可用于癌症的研究，如前列腺癌。
T75424	(±)-Evodiamine	Others	Others
	(±)-Evodiamine，一种天然生物碱，作为Top1的抑制剂，展现了抗炎、抗肥胖及抗肿瘤特性。(±)-Evodiamine能够通过诱导细胞凋亡来抑制多种肿瘤细胞的增殖。
T72737	Ganoderic acid R	Others	Others
	Ganoderic acid R为一种高效的抗癌化合物，通过促进肿瘤细胞系的凋亡(apoptosis)机制来抑制其生长。它对多药耐药(MDR)肿瘤细胞系(KB-A-1/Dox)及敏感肿瘤细胞系(KB-A-1)展现出显著的细胞毒性效应。
TN4277	Isocupressic acid	cAMP; P450; PKA	GPCR/G Protein; Metabolism; Tyrosine Kinase/Adaptors
	Isocupressic acid induces abortion in pregnant cows when ingested primarily during the last trimester, it decrease affects the angiogenesis of the female reproductive system, the decrease in blood flow and apoptosis of corpus luteum-derived endothelial ce
TN5414	Wallichinine
	Wallichinine shows inhibitory activity on platelet aggregation caused by platelet activating factor (PAF). Wallichinine with ABCB1 presents valuable clues for the development of novel MDR reversal reagents from natural products, wallichinine can significa
T3229	Cytochalasin D	ATPase; p38 MAPK; Calcium Channel; Akt; PI3K	Cytoskeletal Signaling; MAPK; Membrane transporter/Ion channel; Metabolism; PI3K/Akt/mTOR signaling
	Cytochalasin D is an actin inhibitor, the removal of actin stress fibers is crucial for the chondrogenic differentiation. It may be an inhibitor of some fertilization processes such as sperm penetration or sperm head decondensation. Cytochalasin D inhibit
TN3364	Agrimonolide	Apoptosis; Dehydrogenase; p38 MAPK; ROS; JAK	Angiogenesis; Apoptosis; Chromatin/Epigenetic; Immunology/Inflammation; JAK/STAT signaling; MAPK; Metabolism; Stem Cells
	Agrimonolide 是一种来自异香豆素的化合物，主要存在于草药Agrimonia pilosa Ledeb 中，具有显著的生物活性。Agrimonolide 通过抑制脂多糖（LPS）诱导的JAK-STATs 和p38 MAPKs 信号通路的激活而发挥抗炎作用。Agrimonolide 及其衍生物去甲阿戈莫内德已显示出能够有效提高肝细胞中胰岛素介导的糖原水平，可能在调节胰岛素抵抗的HepG2细胞中发挥关键作用。Agrimonolide 通过靶向卵巢癌细胞中的SCD1，对癌症的进展和诱导细胞死亡和凋亡表现出抑制作用。特别是，Agrimonolide 对A2780和SKOV-3细胞的增殖、迁移和侵袭表现出剂量依赖性的抑制，同时促进细胞凋亡。该化合物还被发现能诱导铁介导的细胞死亡，同时增加活性氧（ROS）和总铁的水平。Agrimonolide 很容易穿过血脑屏障，表明其在神经系统疾病的治疗应用方面具有潜力。

天然产物

Cat.No: T6S0234

Target: Others

(-)-Syringaresinol

Cat.No: TJS0487

Synonym: DL-Syringaresinol,Lirioresinol b,(-)-丁香脂素

Target: Others

Episyringaresinol 4'-O-β-D-glncopyranoside

Cat.No: TMS0484

Synonym: (-)-丁香树脂酚-4-O-β-D-葡萄糖苷,(-)-Syringaresinol 4-O-β-D-glucopyranosi

Target: Others

Cat.No: T2S0886

Target: Apoptosis, Others

Cat.No: TN1461

Synonym: Butin,漆黄素 ( 紫铆素)

Target: Akt, PI3K, Nrf2

Cat.No: T5S1607

Synonym: Mulberrochromene,桑辛素

Target: NF-κB, Antibacterial, STAT

(+)-(3R,8S)-Falcarindiol

Cat.No: T5S1285

Synonym: Falcarindiol,镰叶芹二醇

Target: Others

Cat.No: T3S1227

Synonym: Aristolactam,Aristololactam I,马兜铃内酰胺I,Aristololactum

Target: Apoptosis, Caspase

Cat.No: TN1804

Synonym: 异水飞蓟素 A,异水飞蓟宾A,水飞蓟素 B2

Target: Apoptosis, Tyrosinase, PPAR, ABC

Cat.No: T3S0081

Synonym: (+-)-Oxypeucedanin,氧化前胡素,Oxypeucadanin

Target: Potassium Channel

Cat.No: TWS2045

Synonym: 鸦胆子素D,鸦胆子苦素D

Target: Apoptosis, Antiviral, Gamma-secretase, Parasite

L-Chicoric Acid

Cat.No: T6S2391

Synonym: (-)-Chicoric acid,trans-Caffeoyltartaric acid,Chicoric acid,L-菊苣酸,dicaffeoyltartaric acid,菊苣酸

Target: Others, HIV Protease

Cat.No: T4S2126

Synonym: 银杏双黄酮,银杏素

Target: Apoptosis, Wnt/beta-catenin, COX, STAT, Autophagy

Cat.No: T6S0525

Target: ERK, p38 MAPK, Akt

Esculentoside A

Cat.No: T3877

Target: NF-κB, COX

Cat.No: T5S2343

Synonym: 乙酰紫草素,Acetyl shikonin

Target: Others, P450, AChE

Picropodophyllotoxin

Cat.No: T3S0027

Synonym: AXL 1717,Picropodophyllin,苦鬼臼毒素

Target: IGF-1R

alpha-Terthienylmethanol

Cat.No: TN2400

Target: Others

ent-16alpha,17-Dihydroxyatisan-3-one

Cat.No: TN3937

Target: P-gp

Desacetylcinobufotalin

Cat.No: TN1572

Target: Others

Cat.No: T13764

Target: Lipoxygenase, Caspase

Betulinic acid methyl ester

Cat.No: TN1442

Target: Antifection

Cat.No: TN4132

2-Hydroxy-3-methylanthraquinone

Cat.No: TN1211

Target: ERK, p38 MAPK, Caspase

Cat.No: T11201

Synonym: 恩镰孢菌素 A1

Target: ERK

Cat.No: TN5050

Target: NADPH-oxidase, VEGFR, p38 MAPK, ROS, Akt, PI3K, mTOR, p53

Isoharringtonine

Cat.No: T75704

Target: Others

1-Decarboxy-3-oxo-ceanothic acid

Cat.No: TN2529

Target: DNA/RNA Synthesis

Spongionellol A

Cat.No: T72802

Target: Others

(±)-Evodiamine

Cat.No: T75424

Target: Others

Ganoderic acid R

Cat.No: T72737

Target: Others

Isocupressic acid

Cat.No: TN4277

Target: cAMP, P450, PKA

Cat.No: TN5414

Cat.No: T3229

Target: ATPase, p38 MAPK, Calcium Channel, Akt, PI3K

Cat.No: TN3364

Target: Apoptosis, Dehydrogenase, p38 MAPK, ROS, JAK

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-03956	Fas Ligand Protein, Human, Recombinant (His) TNLG1A,FASL,FASLG,CD178,CD95-L,APT1LG1,APTL,CD95L,Fas ligand...	Human	P. pastoris (Yeast)
	Fas Ligand, also known as FASLG and CD95L, is the ligand for FAS. It is a transmembrane protein which binds to TNFRSF6/FAS. Interaction of FAS with fas Ligand is critical in triggering apoptosis of some types of cells such as lymphocytes. Fas Ligand may be involved in cytotoxic T-cell mediated apoptosis and in T-cell development. TNFRSF6/FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. Fas Ligand Protei...
TMPJ-00865	VEGF121 Protein, Human, Recombinant (His) VEGFA,VEGF-A,Vascular permeability factor,VPF,血管内皮生长因子,Vascu...	Human	HEK293 Cells
	Human VEGF121, also known as Vascular endothelial growth factor A, VEGFA, Vascular permeability factor, VPF and VEGF, is a homodimeric, heparin-binding glycoprotein which belongs to the platelet-derived growth factor (PDGF)/vascular endothelial growth factor (VEGF) family. VEGF-A is a glycosylated mitogen that specifically acts on endothelial cells and has various effects, including mediating increased vascular permeability, inducing angiogenesis, vasculogenesis, permeabilization of blood vessel...
TMPH-03764	YAP1 Protein, Human, Recombinant (His) YAP1-2gamma,YAP2L,YAP65	Human	P. pastoris (Yeast)
	Transcriptional regulator which can act both as a coactivator and a corepressor and is the critical downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1,...
TMPJ-00675	ZNHIT1 Protein, Human, Recombinant (His) ZNFN4A1,CGBP1,inc finger HIT domain-containing protein 1,cyc...	Human	E. coli
	ZNHIT1 belongs to the ZNHIT1 family and contains one HIT-type zinc finger. It can be phosphorylated on Thr by MAPK11 or MAPK14. ZNHIT1 is a component of the chromatin-remodeling SRCAP complex, which is composed of at least SRCAP, DMAP, RUVBL1, RUVBL2, ACTL6A, YEATS4, ACTR6 and ZNHIT1. ZNHIT1 may play a role in p53-mediated apoptosis induction.
TMPY-04913	Fas Ligand Protein, Rat, Recombinant (His) Fas ligand	Rat	P. pastoris (Yeast)
	Fas Ligand, also known as FASLG and CD95L, is the ligand for FAS. It is a transmembrane protein which binds to TNFRSF6/FAS. Interaction of FAS with fas Ligand is critical in triggering apoptosis of some types of cells such as lymphocytes. Fas Ligand may be involved in cytotoxic T-cell mediated apoptosis and in T-cell development. TNFRSF6/FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. Fas Ligand Protei...
TMPY-04587	Fas Ligand Protein, Mouse, Recombinant (His) CD178,Apt1lg1,Fasl,Cd95l,Faslg,Tnfsf6,gld,Fas ligand,CD95-L,...	Mouse	P. pastoris (Yeast)
	Fas Ligand, also known as FASLG and CD95L, is the ligand for FAS. It is a transmembrane protein which binds to TNFRSF6/FAS. Interaction of FAS with fas Ligand is critical in triggering apoptosis of some types of cells such as lymphocytes. Fas Ligand may be involved in cytotoxic T-cell mediated apoptosis and in T-cell development. TNFRSF6/FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. Fas Ligand Protei...
TMPJ-00215	Fas/CD95 Protein, Mouse, Recombinant (hFc) CD95,Apoptosis-mediating surface antigen FAS,TNFRSF...	Mouse	HEK293 Cells
	Mouse Apoptosis-mediating surface antigen FAS (Fas) belongs to the death receptor subfamily of the TNF receptor superfamily and is designated TNFRSF6. Mouse Fas contains 1 death domain and 3 TNFR-Cys repeats. It detected in various tissues including thymus, liver, lung, heart, and adult ovary. As a receptor for TNFSF6/FASLG, The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which...
TMPH-02549	FHIT Protein, Mouse, Recombinant (His) Adenylylsulfatase,Adenylylsulfate-ammonia adenylyltransferas...	Mouse	E. coli
	Possesses dinucleoside triphosphate hydrolase activity. Cleaves P(1)-P(3)-bis(5'-adenosyl) triphosphate (Ap3A) to yield AMP and ADP. Can also hydrolyze P(1)-P(4)-bis(5'-adenosyl) tetraphosphate (Ap4A), but has extremely low activity with ATP. Exhibits adenylylsulfatase activity, hydrolyzing adenosine 5'-phosphosulfate to yield AMP and sulfate. Exhibits adenosine 5'-monophosphoramidase activity, hydrolyzing purine nucleotide phosphoramidates with a single phosphate group such as adenosine 5'monop...
TMPH-03225	Rabies virus (RABV) (strain CVS-11) Matrix Protein (His & Myc) Matrix protein,M,Phosphoprotein M2	RABV	E. coli
	Plays a major role in assembly, budding and uncoating of virion after membrane fusion. Completely covers the ribonucleoprotein coil and keep it in condensed bullet-shaped form. Inhibits viral transcription and stimulates replication. Plays a major role in early induction of TRAIL-mediated apoptosis in infected neurons. Rabies virus (RABV) (strain CVS-11) Matrix Protein (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 28.1 kDa an...
TMPH-03226	Rabies virus (RABV) (strain PM1503/AVO1) Matrix Protein (GST) Phosphoprotein M2,Matrix protein,M	RABV	E. coli
	Plays a major role in assembly, budding and uncoating of virion after membrane fusion. Completely covers the ribonucleoprotein coil and keep it in condensed bullet-shaped form. Inhibits viral transcription and stimulates replication. Plays a major role in early induction of TRAIL-mediated apoptosis in infected neurons. Rabies virus (RABV) (strain PM1503/AVO1) Matrix Protein (GST) is expressed in E. coli expression system with N-GST tag. The predicted molecular weight is 49.9 kDa and the accessio...
TMPY-03672	Survivin Protein, Human, Recombinant BIRC5,IAP4,API4,baculoviral IAP repeat containing 5,EPR-1	Human	E. coli
	BIRC5, also known as Survivin and EPR-1, is a member of theIAP family. IAP family members usually contain multiple baculovirus IAP repeat (BIR) domains, but BIRC5 has only a single BIR domain. It is expressed cell cycle-dependently and highly expressed at mitosis. As a multitasking protein, BIRC5 has dual roles in promoting cell proliferation and preventing apoptosis. Survivin is a component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation...
TMPJ-00832	Granzyme D/GZMD Protein, Mouse, Recombinant (His) Granzyme D,Gzmd	Mouse	HEK293 Cells
	Granzyme D is a member of the granzyme family of the serine proteases which plays a role in the induction of apoptosis. T cells, lymphohematopoietic stromal cells, and granulated metrial gland cells express granzyme D, but the function of granzyme D is unknown. Previous studies reported that granzyme D is developmentally regulated during pregnancy together with granzymes E, F, and G in granulated metrial gland cells and is upregulated by IL-2 and IL-15. Granzyme D was also suggested to have a ro...
TMPY-03412	GGCT Protein, Human, Recombinant (His) gamma-glutamylcyclotransferase,C7orf24,GGC,γ-glutamylcyclotr...	Human	E. coli
	GGCT belongs to the gamma-glutamylcyclotransferase family. It catalyzes the formation of 5-oxoproline from gamma-glutamyl dipeptides, the penultimate step in glutathione catabolism. GGCT may play a significant role in glutathione homeostasis. GGCT also induces release of cytochrome c from mitochondria with resultant induction of apoptosis. Pseudogenes of GGCT gene are located on the long arm of chromosome 5 and the short arm of chromosomes 2 and 2. Alternatively spliced transcript variants...
TMPH-02226	TEAD3 Protein, Human, Recombinant (His & SUMO) DTEF-1,TEA domain family member 3,Transcriptional enhancer f...	Human	E. coli
	Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expr...
TMPJ-00402	CD117 Protein, Human, Recombinant (hFc) KIT,CD117,v-kit Hardy-Zuckerman 4 feline sarcoma viral oncog...	Human	HEK293 Cells
	C-Kit/SCF R is a type 3 transmembrane receptor for MGF (mast cell growth factor, also known as stem cell factor). c-Kit contains 5 Ig-like C2-type (immunoglobulin-like) domains and 1 protein kinase domain. It belongs to the protein kinase superfamily and CSF-1/PDGF receptor subfamily. SCF R expression on mast cells enables them to infiltrate SCF-secreting tumors where they promote tumor growth and induce local immune suppression. SCF R is up-regulated on dendritic cells by Th2-orTh17-biasing sti...
TMPH-02225	TEAD2 Protein, Human, Recombinant (His & Myc) TEA domain family member 2,Transcriptional enhancer factor T...	Human	E. coli
	Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expr...
TMPH-02574	p53 Protein, Mouse, Recombinant (His & SUMO) Tp53,Cellular tumor antigen p53,Tumor suppressor p53	Mouse	E. coli
	Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 ex...
TMPH-03264	p53 Protein, Rat, Recombinant (His) Tumor suppressor p53,Tp53,Cellular tumor antigen p53	Rat	E. coli
	Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 ex...
TMPH-02876	RIPK1 Protein, Mouse, Recombinant (His) Cell death protein RIP,Receptor-interacting protein 1,Ripk1,...	Mouse	E. coli
	Serine-threonine kinase which is a key regulator of TNF-mediated apoptosis, necroptosis and inflammatory pathways. Exhibits kinase activity-dependent functions that regulate cell death and kinase-independent scaffold functions regulating inflammatory signaling and cell survival. Has kinase-independent scaffold functions: upon binding of TNF to TNFR1, RIPK1 is recruited to the TNF-R1 signaling complex (TNF-RSC also known as complex I) where it acts as a scaffold protein promoting cell survival, i...
TMPH-02222	TEAD1 Protein, Human, Recombinant (His) TEAD1,Transcriptional enhancer factor TEF-1,Transcription fa...	Human	E. coli
	Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expr...
TMPY-04391	Lyn Protein, Human, Recombinant (GST) JTK8,LYN proto-oncogene, Src family tyrosine kinase,p56Lyn,p...	Human	Baculovirus Insect Cells
	Tyrosine-protein kinase Lyn is a member of the Src family of protein tyrosine kinases, which is mainly expressed in hematopoietic cells, in neural tissues liver, and adipose tissue. Tyrosine-protein kinase Lyn has many functions. Lyn kinase may downregulate the expression of stem cell growth factor receptor (KIT). Lyn kinase Acts as an effector of EpoR (erythropoietin receptor) in controlling KIT expression and may play a central role in erythroid differentiation during the switch between prolif...
TMPH-02521	PYCARD Protein, Mouse, Recombinant (His & Myc) Pycard,PYD and CARD domain-containing protein,Apoptosis<...	Mouse	E. coli
	Functions as key mediator in apoptosis and inflammation. Promotes caspase-mediated apoptosis involving predominantly caspase-8 and also caspase-9 in a probable cell type-specific manner. Involved in activation of the mitochondrial apoptotic pathway, promotes caspase-8-dependent proteolytic maturation of BID independently of FADD in certain cell types and also mediates mitochondrial translocation of BAX and activates BAX-dependent apoptosis coupled to activation of caspase-9, -2 and -3. Involved ...
TMPY-01710	IkB alpha/NFKBIA Protein, Human, Recombinant (His) IkB α,IKBA,nuclear factor of kappa light polypeptide gene en...	Human	E. coli
	Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha (IkB alpha, NFKBIA, or IKBA), is a member of the NF-kappa-B inhibitor family that function to inhibit the NF-kB transcription factor. NFKBIA inhibits NF-kB by masking the nuclear localization signals (NLS) of NF-kB proteins and keeping them sequestered in an inactive state in the cytoplasm. Also, NFKBIA blocks the ability of NF-κB transcription factors to bind to DNA, which is required for NF-kB's proper function...
TMPH-01552	IRF1 Protein, Human, Recombinant (GST & His) IRF1,Interferon regulatory factor 1	Human	Baculovirus Insect Cells
	Transcriptional regulator which displays a remarkable functional diversity in the regulation of cellular responses. Regulates transcription of IFN and IFN-inducible genes, host response to viral and bacterial infections, regulation of many genes expressed during hematopoiesis, inflammation, immune responses and cell proliferation and differentiation, regulation of the cell cycle and induction of growth arrest and programmed cell death following DNA damage. Stimulates both innate and acquired imm...

重组蛋白

Fas Ligand Protein, Human, Recombinant (His)

Cat.No: TMPY-03956

Species: Human

Expression System: P. pastoris (Yeast)

VEGF121 Protein, Human, Recombinant (His)

Cat.No: TMPJ-00865

Species: Human

Expression System: HEK293 Cells

YAP1 Protein, Human, Recombinant (His)

Cat.No: TMPH-03764

Species: Human

Expression System: P. pastoris (Yeast)

ZNHIT1 Protein, Human, Recombinant (His)

Cat.No: TMPJ-00675

Species: Human

Expression System: E. coli

Fas Ligand Protein, Rat, Recombinant (His)

Cat.No: TMPY-04913

Species: Rat

Expression System: P. pastoris (Yeast)

Fas Ligand Protein, Mouse, Recombinant (His)

Cat.No: TMPY-04587

Species: Mouse

Expression System: P. pastoris (Yeast)

Fas/CD95 Protein, Mouse, Recombinant (hFc)

Cat.No: TMPJ-00215

Species: Mouse

Expression System: HEK293 Cells

FHIT Protein, Mouse, Recombinant (His)

Cat.No: TMPH-02549

Species: Mouse

Expression System: E. coli

Rabies virus (RABV) (strain CVS-11) Matrix Protein (His & Myc)

Cat.No: TMPH-03225

Species: RABV

Expression System: E. coli

Rabies virus (RABV) (strain PM1503/AVO1) Matrix Protein (GST)

Cat.No: TMPH-03226

Species: RABV

Expression System: E. coli

Survivin Protein, Human, Recombinant

Cat.No: TMPY-03672

Species: Human

Expression System: E. coli

Granzyme D/GZMD Protein, Mouse, Recombinant (His)

Cat.No: TMPJ-00832

Species: Mouse

Expression System: HEK293 Cells

GGCT Protein, Human, Recombinant (His)

Cat.No: TMPY-03412

Species: Human

Expression System: E. coli

TEAD3 Protein, Human, Recombinant (His & SUMO)

Cat.No: TMPH-02226

Species: Human

Expression System: E. coli

CD117 Protein, Human, Recombinant (hFc)

Cat.No: TMPJ-00402

Species: Human

Expression System: HEK293 Cells

TEAD2 Protein, Human, Recombinant (His & Myc)

Cat.No: TMPH-02225

Species: Human

Expression System: E. coli

p53 Protein, Mouse, Recombinant (His & SUMO)

Cat.No: TMPH-02574

Species: Mouse

Expression System: E. coli

p53 Protein, Rat, Recombinant (His)

Cat.No: TMPH-03264

Species: Rat

Expression System: E. coli

RIPK1 Protein, Mouse, Recombinant (His)

Cat.No: TMPH-02876

Species: Mouse

Expression System: E. coli

TEAD1 Protein, Human, Recombinant (His)

Cat.No: TMPH-02222

Species: Human

Expression System: E. coli

Lyn Protein, Human, Recombinant (GST)

Cat.No: TMPY-04391

Species: Human

Expression System: Baculovirus Insect Cells

PYCARD Protein, Mouse, Recombinant (His & Myc)

Cat.No: TMPH-02521

Species: Mouse

Expression System: E. coli

IkB alpha/NFKBIA Protein, Human, Recombinant (His)

Cat.No: TMPY-01710

Species: Human

Expression System: E. coli

IRF1 Protein, Human, Recombinant (GST & His)

Cat.No: TMPH-01552

Species: Human

Expression System: Baculovirus Insect Cells

Cat. No.	Product Name	Target	Signaling Pathways
T35915	Erlotinib-13C6 Erlotinib-13C6
	Erlotinib-13C6 (CP-358774-13C6) is a 13C-labeled Erlotinib. Erlotinib is a directly acting EGFR tyrosine kinase inhibitor, with an IC50 of 2 nM for human EGFR[1]. Erlotinib reduces EGFR autophosphorylation in intact tumor cells with an IC50 of 20 nM. Erlotinib is used for the treatment of non-small cell lung cancer[1].Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process[2]...

同位素标记化合物

Cat.No: T35915

Synonym: Erlotinib-13C6

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