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Search Results for " adrenocortical "

Targets Recommended: PDE

13

抑制剂 & 化合物

3

天然产物

4

重组蛋白

1

同位素标记化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T21865	BC 11-38	PDE	Metabolism
	BC 11-38是一种有效的PDE11生物活性抑制剂，可提高PKA 介导的 ATF-1 磷酸化、 H295R 细胞 cAMP 水平和皮质醇生成。
T4277	Osilodrostat LCI699	Glucocorticoid Receptor; Others; Hydroxylase	Endocrinology/Hormones; Metabolism; Others
	Osilodrostat (LCI699) 是一种有效的人11β-羟化酶和醛固酮合成酶抑制剂，IC50分别值为2.5 和0.7nM。
T1199	Mitotane Mitotan,o,p'-DDD,NCI-C04933,2,4′-DDD,米托坦	Apoptosis; AChR	Apoptosis; Neuroscience
	Mitotane (NCI-C04933) 是 DDD 的同分异构体和 DDT 的衍生物，可作用于肾上腺皮质癌，有抗癌活性。
T12225L	Nevanimibe hydrochloride PD-132301 hydrochloride,ATR101 hydrochloride	Apoptosis; Acyltransferase	Apoptosis; Metabolism
	Nevanimibe hydrochloride (PD-132301 hydrochloride) 是一种口服有效的，选择性酰基辅酶 A：胆固醇 O-酰基转移酶 1 抑制剂，EC50为 9 nM。它抑制 ACAT2，EC50为 368 nM。它诱导细胞凋亡，具有抗肾上腺皮质癌的潜力。
T20802	Flumethasone pivalate Locacorten,NSC-107680,特戊酸氟米松,Lorinden,NSC 107680,NSC107680,Locorten	Others	Others
	Flumethasone pivalate (Locorten) 具有止痒、抗炎和血管收缩的特性，可用于肾上腺皮质抑制、皮肤萎缩、血浆转皮质素结合和毛细血管扩张的研究。
T2531L	Eprosartan KF-108566J free base,Teveten	RAAS	Endocrinology/Hormones
	Eprosartan (SKF-108566J free base) 是一种具有选择性和竞争性的非肽类血管紧张素II受体拮抗剂，对AT1受体亚型具有高亲和力，可用作降压剂。Eprosartan 对血管紧张素 II 受体有抑制作用，在大鼠和人类肾上腺皮质膜中的 IC50 值分别为 9.2 nM 和 3.9 nM。
T8401	Efonidipine hydrochloride monoethanolate NZ-105 hydrochloride monoethanolate,依福地平,盐酸依福地平一乙醇盐	Calcium Channel	Membrane transporter/Ion channel; Metabolism
	Efonidipine hydrochloride monoethanolate (NZ-105 hydrochloride monoethanolate) 是 T 型和 L 型钙离子通道双重阻断剂。
T1473	Trilostane 曲洛斯坦,Win 24540,曲洛司坦	Dehydrogenase	Metabolism
	Trilostane (Win 24540) 是一种3 β-羟化类固醇脱氢酶抑制剂，能够作用于库兴氏综合征。
T19737	Perthane	Others	Others
	Perthane is the diethyl derivative of common pesticide DDD. It may cause adrenocortical atrophy in humans,and also prevent the formation of spontaneous mammary carcinoma.
T21074	Dexamethasone acetate Dexamethasone 21-acetate monohydrate,Decadron-LA,Decadron	Others	Others
	Dexamethasone acetate is an adrenocortical steroid. It is used in the treatment of many conditions, including rheumatic problems, a number of skin diseases, asthma, severe allergies, chronic obstructive lung disease, brain swelling, croup, and antibiotics
T75135	FHD-609	Others	Others
	FHD-609 为含溴结构域蛋白BRD9的抑制剂及降解剂，针对ncBAF，适用于研究含BAF复合亚基突变的多种癌症。FHD-609与Telomelysin或INO5401联用，或对肾上腺皮质癌(ACC)的研究具有潜在作用。
T35858	Adrenomedullin (22-52) (human) (trifluoroacetate salt)
	Adrenomedullin (22-52) is a C-terminal fragment of adrenomedullin (1-52) . In vitro, adrenomedullin (22-52) reduces basal corticosterone production in a mixture of rat adrenocortical and adrenomedulllary cells. It also reverses increases in ACTH-stimulated corticosterone production induced by adrenomedullin (1-52). Adrenomedulin (22-52) (0.5 and 5 μg/kg/min) has no effect on basal regional cerebral blood flow but reverses increases in regional cerebral blood flow induced by rat adrenomedullin in...
T72213	Efonidipine hydrochloride NZ-105 hydrochloride	Others	Others
	Efonidipine(NZ-105)盐酸盐是T 型和L 型钙离子通道双重阻断剂。

化合物

Cat.No: T21865

Target: PDE

Cat.No: T4277

Synonym: LCI699

Target: Glucocorticoid Receptor, Others, Hydroxylase

Cat.No: T1199

Synonym: Mitotan,o,p'-DDD,NCI-C04933,2,4′-DDD,米托坦

Target: Apoptosis, AChR

Nevanimibe hydrochloride

Cat.No: T12225L

Synonym: PD-132301 hydrochloride,ATR101 hydrochloride

Target: Apoptosis, Acyltransferase

Flumethasone pivalate

Cat.No: T20802

Synonym: Locacorten,NSC-107680,特戊酸氟米松,Lorinden,NSC 107680,NSC107680,Locorten

Target: Others

Cat.No: T2531L

Synonym: KF-108566J free base,Teveten

Target: RAAS

Efonidipine hydrochloride monoethanolate

Cat.No: T8401

Synonym: NZ-105 hydrochloride monoethanolate,依福地平,盐酸依福地平一乙醇盐

Target: Calcium Channel

Cat.No: T1473

Synonym: 曲洛斯坦,Win 24540,曲洛司坦

Target: Dehydrogenase

Cat.No: T19737

Target: Others

Dexamethasone acetate

Cat.No: T21074

Synonym: Dexamethasone 21-acetate monohydrate,Decadron-LA,Decadron

Target: Others

Cat.No: T75135

Target: Others

Adrenomedullin (22-52) (human) (trifluoroacetate salt)

Cat.No: T35858

Efonidipine hydrochloride

Cat.No: T72213

Synonym: NZ-105 hydrochloride

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T3033	Deoxycorticosterone acetate 醋酸去氧皮质酮,DOC acetate,Cortexone acetate,11-Deoxycorticosterone acetate,醋酸脱氧皮质酮	Glucocorticoid Receptor; Endogenous Metabolite; Adrenergic Receptor	Endocrinology/Hormones; GPCR/G Protein; Metabolism; Neuroscience
	Deoxycorticosterone acetate (Cortexone acetate) 是肾上腺产生的类固醇激素，具有盐皮质激素活性，并作为醛固酮的前体。
T0948L	Corticosterone 皮质酮,17-Deoxycortisol,11β,21-Dihydroxyprogesterone,Kendall's compound B,肾上腺酮,Corticosterone (From plants)	Glucocorticoid Receptor; Endogenous Metabolite	Endocrinology/Hormones; Metabolism
	Corticosterone (Kendall's compound B) 是一种肾上腺皮质类固醇，有盐皮质激素和糖皮质激素的活性，具有口服活性。Corticosterone 参与体内能量、免疫反应和应激反应的调节。
T36472	Tetrahydro-11-deoxy Cortisol	Others	Others
	Tetrahydro-11-deoxy cortisol (THS) is the primary urinary metabolite of 11-deoxycortisol. Urinary excretion of THS is elevated in patients with 11β-hydroxylase deficiency, a condition resulting from mutations in the cytochrome P450 (CYP) isoform CYP11B1. Urinary levels of THS are also elevated in patients with adrenocortical carcinoma (ACC) and adrenocortical adenoma (ACA) but are higher in patients with ACC compared to ACA.

天然产物

Deoxycorticosterone acetate

Cat.No: T3033

Synonym: 醋酸去氧皮质酮,DOC acetate,Cortexone acetate,11-Deoxycorticosterone acetate,醋酸脱氧皮质酮

Target: Glucocorticoid Receptor, Endogenous Metabolite, Adrenergic Receptor

Cat.No: T0948L

Synonym: 皮质酮,17-Deoxycortisol,11β,21-Dihydroxyprogesterone,Kendall's compound B,肾上腺酮,Corticosterone (From plants)

Target: Glucocorticoid Receptor, Endogenous Metabolite

Tetrahydro-11-deoxy Cortisol

Cat.No: T36472

Target: Others

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPJ-01319	TINAGL1 Protein, Human, Recombinant (His) LCN7,Tubulointerstitial nephritis antigen-like (TINAGL1),Oxi...	Human	HEK293 Cells
	TINAGL1 is a secreted protein and contains one SMB (somatomedin-B) domain. TINAGL1 is expressed in aorta, lymph nodes, heart, bone marrow, placenta, lung, kidney, skeletal muscle, pancreas, thyroid, adrenal gland and so on. TINAGL1 may be implicated in the adrenocortical zonation and in mechanisms for repressing the CYP11B1 gene expression in adrenocortical cells.
TMPY-04118	Livin/BIRC7 Protein, Human, Recombinant (His) MLIAP,baculoviral IAP repeat containing 7,RNF50,KIAP,ML-IAP,...	Human	E. coli
	BIRC7, a new member of inhibitor of the apoptosis protein family, is expressed in fetal tissues and most solid tumors in humans. BIRC7/livin expression is a novel prognostic marker in adult acute leukemia. Livin/BIRC7 is a member of the inhibitors of apoptosis proteins family, which are involved in tumor development through the inhibition of caspases. Livin/BIRC7 is specifically over-expressed in ACC, suggesting that it might be involved in adrenocortical tumorigenesis and represent a new molecu...
TMPY-03287	RRM1 Protein, Human, Recombinant (His & GST) ribonucleotide reductase M1,R1,RR1,RIR1	Human	Baculovirus Insect Cells
	RRM1 is a subunit of ribonucleoside-diphosphate reductase which is constituted by two subunits. Ribonucleoside-diphosphate reductase is an enzyme essential for the production of deoxyribonucleotides prior to DNA synthesis in S phase of dividing cells. RRM1 is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocort...
TMPY-02228	p53 Protein, Cynomolgus, Recombinant tumor protein p53,p53,TP53	Cynomolgus	E. coli
	p53, also known as Tp53, is a DNA-binding protein which belongs to the p53 family. It contains transcription activation, DNA-binding, and oligomerization domains. p53 protein is expressed at low level in normal cells and at a high level in a variety of transformed cell lines, where it's believed to contribute to transformation and malignancy. p53 (TP53) is a transcription factor whose protein levels and post-translational modification state alter in response to cellular stress (such as DNA damag...

重组蛋白

TINAGL1 Protein, Human, Recombinant (His)

Cat.No: TMPJ-01319

Species: Human

Expression System: HEK293 Cells

Livin/BIRC7 Protein, Human, Recombinant (His)

Cat.No: TMPY-04118

Species: Human

Expression System: E. coli

RRM1 Protein, Human, Recombinant (His & GST)

Cat.No: TMPY-03287

Species: Human

Expression System: Baculovirus Insect Cells

p53 Protein, Cynomolgus, Recombinant

Cat.No: TMPY-02228

Species: Cynomolgus

Expression System: E. coli

Cat. No.	Product Name	Target	Signaling Pathways
TMIH-0587	Trilostane-d3
	Trilostane-d3 是 Trilostane 的氘代化合物。Trilostane 的 CAS 号为 13647-35-3。Trilostane 是一种3 β-羟化类固醇脱氢酶抑制剂，能够作用于库兴氏综合征。

同位素标记化合物

Cat.No: TMIH-0587

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