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Search Results for " tenofovir "

Targets Recommended: HBV HIV Protease Reverse Transcriptase

22

抑制剂 & 化合物

1

同位素标记化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T1649	Tenofovir 替诺福韦,泰诺福韦,PMPA,TDF,GS 1278	HBV; HIV Protease; Reverse Transcriptase	Microbiology/Virology; Proteases/Proteasome
	Tenofovir (GS 1278) 是一种核苷酸逆转录酶抑制剂，可研究 HIV 和慢性乙型肝炎。
T28946	Tenofovir exalidex Tenofovir,HDP-Tenofovir,CMX-157,CMX157,CMX 157	Antiviral	Immunology/Inflammation
	Tenofovir exalidex (CMX 157) 是一种非环核苷酸类似物 Tenofovir 的脂质结合物，对野生型和抗逆转录病毒耐药的 HIV 毒株，包括多药核苷/核苷酸类似物耐药病毒，都有活性。Tenofovir exalidex 对人外周血单个核细胞中所有主要的HIV-1和HIV-2亚型以及单核细胞来源的巨噬细胞中所有 HIV-1 菌株具有活性，EC50 范围在 0.2 和 7.2 nM 之间。Tenofovir exalidex 具有口服活性，无明显毒性。Tenofovir exalidex 对 HBV 也有活性。
T2409L	Tenofovir Disoproxil Fumarate GS-1278 Disoproxil Fumarate,Tenofovir DF,富马酸替诺福韦酯	HBV; HIV Protease; Reverse Transcriptase	Microbiology/Virology; Proteases/Proteasome
	Tenofovir Disoproxil Fumarate (GS-1278 Disoproxil Fumarate) 是一种核苷酸逆转录酶抑制剂，有潜力研究艾滋病和慢性乙型肝炎。
T7282	Tenofovir alafenamide hemifumarate GS-7340 (hemifumarate),Tenofovir alafenamide fumarate,替诺福韦艾拉酚胺富马酸盐	HIV Protease; Reverse Transcriptase	Microbiology/Virology; Proteases/Proteasome
	Tenofovir alafenamide hemifumarate (GS-7340 hemifumarate) 是 HIV 逆转录酶核苷酸抑制剂替诺福韦的口服膦酰胺前药。
T12814	(S)-Tenofovir (S)-替诺福韦,(S)-PMPA,(S)-GS 1278,(S)-TDF	Others	Others
	(S)-Tenofovir ((S)-PMPA) 是Tenofovir 的活性较低的S-对映体，Tenofovir 是一种核苷酸逆转录酶抑制剂。
T39043	Tenofovir amibufenamide HS-10234	HBV	Microbiology/Virology
	Tenofovir amibufenamide (HS-10234) (HS-10234) 是一种 Tenofovir 前药，是一种具有口服活性的抗病毒化合物。Tenofovir amibufenamide 对乙型肝炎病毒 (HBV)具有抑制作用，可用于慢性乙型肝炎 (CHB) 研究。
T2409	Tenofovir alafenamide 替诺福韦艾拉酚胺,替诺福韦,GS-7340	HIV Protease; Reverse Transcriptase	Microbiology/Virology; Proteases/Proteasome
	Tenofovir alafenamide (GS-7340) 是一种核苷酸逆转录酶抑制剂和抗逆转录病毒替诺福韦的新型酯类前药。
T41249	Tenofovir alafenamide fumarate GS-7340 fumarate	HIV Protease	Microbiology/Virology; Proteases/Proteasome
	Tenofovir alafenamide fumarate (GS-7340 fumarate) 是一种可口服的 Tenofovir 前体化合物。Tenofovir alafenamide fumarate 具有抗 HIV 活性，可用于预防 HIV 感染。
T7111	Tenofovir Disoproxil 替诺福韦酯,GS 4331,Bis(POC)-PMPA	HBV; HIV Protease; Reverse Transcriptase	Microbiology/Virology; Proteases/Proteasome
	Tenofovir Disoproxil (GS 4331) 是一种核苷酸逆转录酶抑制剂，用于治疗 HIV 和慢性乙型肝炎。
T63290	(R,1R)-Tenofovir amibufenamide (R,1R)-HS-10234	Antiviral	Immunology/Inflammation
	(R,1R)-Tenofovir amibufenamide ((R,1R)-HS-10234) 可用于 Tenofovir 前药,可口服，具有抗病毒活性。Tynofovir 是一种核苷酸逆转录酶抑制剂。
T37909	Tenofovir diphosphate	Others	Others
	Tenofovir diphosphate (TFV-DP) is a competitive inhibitor of DNA polymerases, specifically targeting dATP, and it serves as a substrate for the reverse transcriptase (RT) of human immunodeficiency virus type 1 (HIV-1)[1].
T40238	Tenofovir-C3-O-C12-trimethylsilylacetylene ammonium Tenofovir-C3-O-C12-trimethylsilylacetylene ammonium	Others	Others
	Tenofovir-C3-O-C12-trimethylsilylacetylene (ammonium) displays a prolonged half-life (t1/2) compared to tenofovir in human liver microsomes. Moreover, it demonstrates potent in vitro anti-HIV activity and improves in vivo pharmacokinetic properties.
T37523	Tenofovir diphosphate (sodium salt)	Others	Others
	Tenofovir diphosphate is an inhibitor of HIV reverse transcriptase (Kis = 0.022 and 1.55 μM for RNA and DNA, respectively) and hepatitis B virus (HBV) polymerase (Ki = 0.18 μM). It is selective for these enzymes over DNA polymerase α and β, as well as mitochondrial DNA polymerase γ (Kis = 5.2, 81.7, and 59.5 μM, respectively). Tenofovir diphosphate is formed intracellularly through phosphorylation of the prodrugs tenofovir and tenofovir disoproxil by nucleotide kinases. Increased levels of tenof...
T40239	Tenofovir-C3-O-C15-CF3 ammonium Tenofovir-C3-O-C15-CF3 ammonium	Others	Others
	Tenofovir-C3-O-C15-CF3 (ammonium) demonstrates prolonged half-life values compared to tenofovir in human liver microsomes. It exhibits potent anti-HIV activity in vitro and enhances pharmacokinetic properties in vivo.
T37910	Tenofovir diphosphate triethylamine	Others	Others
	Tenofovir diphosphate triethylamine (TFV-DP triethylamine) is a competitive inhibitor of DNA polymerases for dATP, functioning as a substrate for HIV type 1 reverse transcriptase (HIV-1 RT)[1].
T1649L	Tenofovir hydrate	Others	Others
	Tenofovir hydrate (GS 1278 hydrate) 是一种核苷酸逆转录酶抑制剂，用于治疗HIV 和慢性乙型肝炎 (HBV) 。
T21775	Tenofovir maleate	Others	Others
	Tenofovir maleate (GS 1278 maleate) 是一种核苷酸逆转录酶 (nucleotide reverse transcriptase) 抑制剂，用于治疗HIV 和慢性乙型肝炎。
T28945	Tenofovir disoproxil aspartate CKD-390,CKD390,CKD 390	Others	Others
	Tenofovir disoproxil aspartate, a nucleotide reverse transcriptase inhibitor, is used potentially for the treatment of HBV infection.
T12127	9-Propenyladenine Mutagenic Impurity of Tenofovir Disoproxil,替诺福韦酯杂质,Tenofovir Impurity 2	Others	Others
	9-Propenyladenine is a mutagenic impurity in tenofovir disoproxil fumarate.
T13457	(Z)-9-Propenyladenine (Z)-替诺福韦酯杂质,(Z)-Mutagenic Impurity of Tenofovir Disoproxil	Others	Others
	(Z)-9-Propenyladenine is a mutagenic impurity in tenofovir disoproxil fumarate.
T37547	trans-Urocanic Acid trans-UCA,(E)-Urocanic acid
	trans-Urocanic Acid ((E)-Urocanic acid) 是一种主要分布于海马体和前额叶皮层的化合物，是顺式UCA的异构体，是表皮紫外线保护剂，可增强替诺福韦艾拉酚胺在长效HIV应用中的稳定性。trans-urocanic acid 可有效调节免疫功能，可在体外抑制人类自然杀伤细胞的活性，可用于研究阿尔茨海默病。
T72593	Antiviral agent 9	Others	Others
	Antiviral agent 9 抗HIV-1的EC50达到皮摩尔浓度（0.006 nM），与 tenofovir alafenamide fumarate（TAF）相比，选择性指数（SI）高近 300 倍。

化合物

Cat.No: T1649

Synonym: 替诺福韦,泰诺福韦,PMPA,TDF,GS 1278

Target: HBV, HIV Protease, Reverse Transcriptase

Tenofovir exalidex

Cat.No: T28946

Synonym: Tenofovir,HDP-Tenofovir,CMX-157,CMX157,CMX 157

Target: Antiviral

Tenofovir Disoproxil Fumarate

Cat.No: T2409L

Synonym: GS-1278 Disoproxil Fumarate,Tenofovir DF,富马酸替诺福韦酯

Target: HBV, HIV Protease, Reverse Transcriptase

Tenofovir alafenamide hemifumarate

Cat.No: T7282

Synonym: GS-7340 (hemifumarate),Tenofovir alafenamide fumarate,替诺福韦艾拉酚胺富马酸盐

Target: HIV Protease, Reverse Transcriptase

(S)-Tenofovir

Cat.No: T12814

Synonym: (S)-替诺福韦,(S)-PMPA,(S)-GS 1278,(S)-TDF

Target: Others

Tenofovir amibufenamide

Cat.No: T39043

Synonym: HS-10234

Target: HBV

Tenofovir alafenamide

Cat.No: T2409

Synonym: 替诺福韦艾拉酚胺,替诺福韦,GS-7340

Target: HIV Protease, Reverse Transcriptase

Tenofovir alafenamide fumarate

Cat.No: T41249

Synonym: GS-7340 fumarate

Target: HIV Protease

Tenofovir Disoproxil

Cat.No: T7111

Synonym: 替诺福韦酯,GS 4331,Bis(POC)-PMPA

Target: HBV, HIV Protease, Reverse Transcriptase

(R,1R)-Tenofovir amibufenamide

Cat.No: T63290

Synonym: (R,1R)-HS-10234

Target: Antiviral

Tenofovir diphosphate

Cat.No: T37909

Target: Others

Tenofovir-C3-O-C12-trimethylsilylacetylene ammonium

Cat.No: T40238

Synonym: Tenofovir-C3-O-C12-trimethylsilylacetylene ammonium

Target: Others

Tenofovir diphosphate (sodium salt)

Cat.No: T37523

Target: Others

Tenofovir-C3-O-C15-CF3 ammonium

Cat.No: T40239

Synonym: Tenofovir-C3-O-C15-CF3 ammonium

Target: Others

Tenofovir diphosphate triethylamine

Cat.No: T37910

Target: Others

Tenofovir hydrate

Cat.No: T1649L

Target: Others

Tenofovir maleate

Cat.No: T21775

Target: Others

Tenofovir disoproxil aspartate

Cat.No: T28945

Synonym: CKD-390,CKD390,CKD 390

Target: Others

9-Propenyladenine

Cat.No: T12127

Synonym: Mutagenic Impurity of Tenofovir Disoproxil,替诺福韦酯杂质,Tenofovir Impurity 2

Target: Others

(Z)-9-Propenyladenine

Cat.No: T13457

Synonym: (Z)-替诺福韦酯杂质,(Z)-Mutagenic Impurity of Tenofovir Disoproxil

Target: Others

trans-Urocanic Acid

Cat.No: T37547

Synonym: trans-UCA,(E)-Urocanic acid

Antiviral agent 9

Cat.No: T72593

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
TMID-0011	rac Tenofovir-d6
	rac Tenofovir-d6 是 rac Tenofovir 的氘代化合物。rac Tenofovir 的 CAS 号为 107021-12-5。

同位素标记化合物

rac Tenofovir-d6

Cat.No: TMID-0011

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