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Search Results for " tgf-β receptor "
Targets Recommended: Others 5-HT Receptor Adenosine Receptor

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抑制剂 & 化合物

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Cat. No. Product Name
L4100 TGF-β/Smad靶点化合物库

184 compounds
184 个 TGF-β/Smad 靶点相关的小分子化合物的特有集合，用于高通量、高内涵筛选；
L2195 抗前列腺癌化合物库

2070 compounds
2070 种与前列腺癌相关的化合物，可以用于高通量和高内涵筛选

化合物库

TGF-β/Smad靶点化合物库
Cat.No: L4100
Compounds: 184
抗前列腺癌化合物库
Cat.No: L2195
Compounds: 2070
Cat. No. Product Name Target Signaling Pathways
T16378 Ogerin

Others; 5-HT Receptor; Adenosine Receptor GPCR/G Protein; Neuroscience; Others
Ogerin 是选择性 GPR68正向别构调节剂(pEC50:6.83)。它能够抑制小鼠对恐惧记忆的回忆。它对 A2A 受体具有适中的拮抗作用(Ki:220 nM)。对 5-HT2B 受体的拮抗作用较弱(Ki:736 nM)。
T16708 R-268712

ALK; TGF-beta/Smad Angiogenesis; Stem Cells; Tyrosine Kinase/Adaptors
R-268712 是选择性的 ALK5 抑制剂(IC50:2.5 nM)。
T5197 BIBF0775

ALK; TGF-beta/Smad Angiogenesis; Stem Cells; Tyrosine Kinase/Adaptors
BIBF0775 是一种选择性的TGFβI 型受体抑制剂(IC50:34 nM)。
T2462 SB-505124

ALK; TGF-beta/Smad Angiogenesis; Stem Cells; Tyrosine Kinase/Adaptors
SB505124 是TGF-βI 型受体 (ALK4，ALK5，ALK7) 的选择性抑制剂，能够抑制 ALK4 (IC50:129 nM)，ALK5 (IC50:47 nM)，对 ALK1，2，3 或 6 无影响。
T2123 LY2109761

Autophagy; TGF-beta/Smad Autophagy; Stem Cells
LY2109761 是一种新型选择性 TGF-β 受体 I/II 型 (TβRI/II) 双重抑制剂，Ki 分别为 38 nM 和 300 nM。
T1800 GW788388

GW 788388

 ALK; TGF-beta/Smad Angiogenesis; Stem Cells; Tyrosine Kinase/Adaptors
GW788388 是一种 ALK5抑制剂(IC50:18 nM)。它也抑制 TGF-β II 型受体和激活素 II 型受体的活性，但对 BMP II 型受体无影响。
T4662 SJ000291942

TGF-beta/Smad Stem Cells
SJ000291942 是一种经典骨形态发生蛋白 (BMP) 信号传导途径的激活剂。其中 BMP 是一种转化生长因子 β 分泌信号分子家族的成员。
T4975 SM 16

ALK; TGF-beta/Smad Angiogenesis; Stem Cells; Tyrosine Kinase/Adaptors
SM 16 是一种 ALK5 (Ki:10 nM) 激酶抑制剂，也是一种 ALK4 激酶 (Ki:1.5 nM) 抑制剂。
T1914 K02288

K 02288

 ALK; TGF-beta/Smad Angiogenesis; Stem Cells; Tyrosine Kinase/Adaptors
K 02288是骨形态发生蛋白 (BMP) I 型受体抑制剂，能够抑制 ALK1 (IC50:1.8nM)、ALK2 (IC50:1.1nM)、ALK6 (IC50:6.4nM)。对 ALK3 和 ALK6 的抑制稍弱，IC50在 5-34 nM 之间。
T1942 DMH-1

DMH1

 ALK; Autophagy; TGF-beta/Smad Angiogenesis; Autophagy; Stem Cells; Tyrosine Kinase/Adaptors
DMH-1 是一种选择性 BMP 抑制剂，对 ALK1、ALK2、ALK3和 ALK6的 IC50值分别为 27、107.9、<5和 47.6 nM。
T1763 SB 525334

SB525334

 ALK; TGF-beta/Smad Angiogenesis; Stem Cells; Tyrosine Kinase/Adaptors
SB525334是转化生长因子β1受体 (ALK5) 选择性抑制剂，IC50=14.3 nM。
T1943 ML347

LDN 193719

 ALK; TGF-beta/Smad Angiogenesis; Stem Cells; Tyrosine Kinase/Adaptors
ML347 (LDN 193719) 是一种选择性的 ALK1/ALK2 抑制剂，它们的 IC50 分别为 46/32 nM，比对 ALK3 的抑制性高 300 倍。
T2510 Galunisertib

LY2157299

 TGF-beta/Smad Stem Cells
Galunisertib (LY2157299) 是一种TGF-β 受体 I 型 (TGF-βRI) 激酶的选择性抑制剂，其IC50=56 nM。
T2098 A 77-01

A77-01

 ALK; TGF-beta/Smad Angiogenesis; Stem Cells; Tyrosine Kinase/Adaptors
A 77-01 是 TGF-βI 型受体家族 ALK5抑制剂(IC50:25 nM)。
T2109 SD-208

ALK5 Inhibitor V,SD208

 TGF-beta/Smad Stem Cells
SD-208 (ALK5 Inhibitor V) 是 TGF-βRI (ALK5) 的选择性抑制剂(IC50:48 nM)，对其选择性是对 TGF-βRII 的 100 多倍。
T8730 BMS986260

TGF-beta/Smad Stem Cells
BMS986260是一种口服有活力的选择性TGFβR1抑制剂，是免疫肿瘤学药物。它能够抑制 MINK 和 NHLF 细胞系中 TGFβ 介导的 pSMAD2/3 核转位，IC50值分别为 350 nM 和 190 nM。它对 TGFβR1 的选择比 TGFβR2 同功酶高。
T3031 A 83-01

ALK5 Inhibitor IV,A8301

 ALK; TGF-beta/Smad Angiogenesis; Stem Cells; Tyrosine Kinase/Adaptors
A 83-01 (ALK5 Inhibitor IV) 是一种 TGF-βI 型受体 ALK5、ALK4 和 ALK7 的抑制剂 (IC50=12/45/7.5 nM)。A 83-01 可促进小鼠成纤维细胞重编程为 iPSCs。A 83-01 可用于类器官培养。
T5125 LY3200882

TGF-beta/Smad Stem Cells
LY3200882 是一种高度选择性的、口服活性的、具有 ATP 竞争性的 TGF-β 受体 1 型 (ALK5) 抑制剂(IC50:38.2 nM)。它能够抑制多种促肿瘤活性，可用作免疫调节剂。
T1944 LDN-214117

ALK; TGF-beta/Smad Angiogenesis; Stem Cells; Tyrosine Kinase/Adaptors
LDN214117 是一种高效的 ALK2 选择性抑制剂(IC50:22nM)，也是一种 BMP6 抑制剂(IC50:100nM)，对ALK5抑制力弱100倍。
T2048 LY-364947

LY 364947,HTS466284

 MLK; Casein Kinase; TGF-beta/Smad; RIP kinase Apoptosis; MAPK; Metabolism; NF-κB; Stem Cells
LY-364947 (HTS466284) 是有效的、ATP 竞争性的TGFβR-I 抑制剂(IC50:59 nM)，是对 TGFβR-II 选择性的 7 倍。
T1935 LDN193189

LDN-193189,DM-3189,LDN 193189

 ALK; TGF-beta/Smad Angiogenesis; Stem Cells; Tyrosine Kinase/Adaptors
LDN193189 (DM-3189) 是一种 BMP I 型受体的选择性抑制剂，可以抑制 ALK2 和 ALK3 (IC50=5/30 nM)，对 ALK4、ALK5 和 ALK7 的活性较弱。LDN193189 可以用于进行性骨化性纤维发育不良的研究。
T23127 PD-161570

PD 161570

 EGFR; FGFR; PDGFR; Src Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
PD-161570 是一种有效的 ATP 竞争性人 FGF-1 受体抑制剂，IC50 为 39.9 nM，Ki 为 42 nM。它还是骨形态发生蛋白 (BMPs) 和TGF-β信号抑制剂。它抑制PDGF 刺激的自磷酸化和FGF-1受体磷酸化，IC50分别为 450 和 622 nM。它抑制 PDGFR、EGFR 和 c-Src 酪氨酸激酶，IC50 值分别为 310、240 和 44 nM。
T8330 BIO-013077-01

6-(3-(6-甲基吡啶-2-基)-1H-吡唑-4-基)喹噁啉

 TGF-beta/Smad Stem Cells
BIO-013077-01 是吡唑类TGF-β抑制剂。
T1977 Dorsomorphin

Compound C,BML-275

 AMPK; Autophagy; TGF-beta/Smad Autophagy; Chromatin/Epigenetic; PI3K/Akt/mTOR signaling; Stem Cells
Dorsomorphin (BML-275) 是一种 AMPK 抑制剂 (Ki=109 nM)，具有选择性和 ATP 竞争性。Dorsomorphin 可以抑制 BMP I 型受体 ALK2、ALK3 和 ALK6。Dorsomorphin 可诱导自噬，具有抗肿瘤活性。
T7799 BMP signaling agonist sb4

SB 4

 TGF-beta/Smad Stem Cells
BMP signaling agonist sb4 (SB 4) 是苯并恶唑骨形态发生蛋白 4 (BMP4) 信号激动剂(EC50:74 nM)，能够稳定细胞内 p-SMAD-1/5/9 ，激活 BMP 信号。它还能激活典型 BMP 信号通路中的 BMP4 靶基因 (DNA 结合抑制剂，Id1和Id3)。
T6337 RepSox

ALK5 Inhibitor II,SJN 2511,E-616452

 ALK; TGF-beta/Smad Angiogenesis; Stem Cells; Tyrosine Kinase/Adaptors
RepSox (ALK5 Inhibitor II) 是一种 TGFβR-1/ALK5 的抑制剂，可以抑制 ATP 与 ALK5 结合 以及 ALK5 自磷酸化 (IC50=23/4 nM)，具有选择性。RepSox 可以诱导 MEFs 细胞的脂肪生成。
T1900 LDN-212854

LDN212854,BMP Inhibitor III

 ALK; TGF-beta/Smad Angiogenesis; Stem Cells; Tyrosine Kinase/Adaptors
LDN-212854 (BMP Inhibitor III) 是一种新型BMP 抑制剂，抑制 ALK2 的IC50=1.3 nM，比对ALK1，ALK3，ALK4和ALK5的抑制性高2，66，1641和7135倍。
T1726 SB-431542

4-[4-(1,3-苯并二唑-5-基)-5-(2-吡啶基)-1H-咪唑-2-基]-苯酰胺水合物,SB 431542

 ALK; TGF-beta/Smad Angiogenesis; Stem Cells; Tyrosine Kinase/Adaptors
SB-431542 是一种 ALK5/TGF-β type I Receptor 的抑制剂 (IC50=94 nM)，具有选择性。SB 431542 对 ALK4 和 ALK7 也有抑制活性，但对其他蛋白没有抑制作用。SB 431542 可以用于干细胞的诱导分化。
T2273 ITD-1

4-[1,1'-联苯]-4-基-1,4,5,6,7,8-六氢-2,7,7-三甲基-5-氧代-3-喹啉羧酸乙酯

 TGF-beta/Smad Stem Cells
ITD1 是一个选择性的TGFβ受体抑制剂(IC50:460 nM)。
T6496 Vactosertib

TEW-7197,EW-7197

 ALK; TGF-beta/Smad Angiogenesis; Stem Cells; Tyrosine Kinase/Adaptors
Vactosertib (EW-7197) 是有效的、具有 ATP 竞争性的、具有口服活性的激活素受体样激酶 5 (ALK5) 抑制剂(IC50:12.9 nM)。它还以纳摩尔浓度抑制 ALK2 和 ALK4 (IC50为 17.3 nM)，表现出强大的抗转移活性和抗癌作用。
T9010 IMM-H007

Others; AMPK Chromatin/Epigenetic; Others; PI3K/Akt/mTOR signaling
IMM-H007 是一种新型降脂剂，可增加 abca1 蛋白的表达。
T6146 Dorsomorphin dihydrochloride

BML-275 2HCl,Compound C dihydrochloride,6-[4-[2-(1-哌啶基)乙氧基]苯基]-3-(4-吡啶基)吡唑并[1,5-A]嘧啶,Dorsomorphin (Compound C) 2HCl,Compound C 2HCl,BML-275 dihydrochloride

 AMPK; Autophagy; TGF-beta/Smad Autophagy; Chromatin/Epigenetic; PI3K/Akt/mTOR signaling; Stem Cells
Dorsomorphin dihydrochloride (BML-275 2HCl) 是一种 AMPK 抑制剂 (Ki=109 nM)，具有选择性和 ATP 竞争性。Dorsomorphin dihydrochloride 可以抑制 BMP I 型受体 ALK2、ALK3 和 ALK6。Dorsomorphin dihydrochloride 可诱导自噬，具有抗肿瘤活性。
T26958 CAY10583

CAY 10583,CAY-10583

 Others Others
CAY10583 is an agonist of leukotriene B4 receptor type 2 (BLT2). CAY10583 directly promotes keratinocyte migration and indirectly enhances fibroblast proliferation by increasing keratinocyte production of bFGF1 and TGF-β, leadng to accelerate wound closur
T77189 Sudubrilimab

Sudubrilimab (HS636) 是一种针对 PDL1的 Ig G1-kappa 单克隆抗体。Sudubrilimab 在重链的 C 末端与 TGF-β1受体 Ⅱ 胞外域 (TGFBR2-ECD) 融合，可在免疫抑制性肿瘤微环境中隔离 PD-1/PD-L1通路和 TGF-β 生物活性。
T70932 L6H9

Others Others
L6H9 is a novel inhibitor of myeloid differentiation factor 2 (MD2), suppressing HG-induced expression of ACE and AT1 receptor and Angiotensin II (AngII) production in renal NRK‐52E cells, resulting in the decrease in fibrosis markers such as TGF-β and collagen IV.
T63498 ALK5-IN-6

Others Others
ALK5-IN-6 是 ALK5 的有效抑制剂。 ALK5-IN-6 具有潜力进行 TGF-β 相关疾病和病症的研究，包括但不限于肿瘤、炎症性疾病、纤维化疾病、自身免疫性疾病等。其中转化生长因子 β (TGF-β) 是一种多功能细胞因子，通过细胞表面的复杂受体信号通路以自分泌、旁分泌和内分泌的方式参与调控细胞增殖、分化和凋亡。
T78790 J-1048

Others Others
J-1048 是一种专门针对激活素受体样激酶 5 (ALK5) 的抑制剂，能够有效地通过抑制 TGF-β/Smad 信号通路来防止 TAA 诱导的小鼠肝纤维化。
T63114 ALK5-IN-7

Others Others
ALK5-IN-7 是一种 ALK5 的有效抑制剂。转化生长因子 β (TGF-β) 是一种多功能细胞因子，能够利用细胞表面的复杂受体信号通路，通过自分泌、旁分泌和内分泌的方式参与调控细胞增殖、分化和凋亡。ALK5-IN-7 具有潜力进行 TGF-β 相关疾病和病症的研究（包括但不限于肿瘤、纤维化疾病、炎症性疾病、自身免疫性疾病等）。
T26925 Butaprost

Butaprostum,TR-4979,(R)-Butaprost

 Others Others
Butaprost is a chemical compound that functions as a selective agonist for the prostaglandin E receptor (EP2). It exhibits an EC50 of 33 nM and a Ki of 2.4 μM when interacting with the murine EP2 receptor. However, Butaprost demonstrates lower activity against murine EP1, EP3, and EP4 receptors. Furthermore, it effectively attenuates fibrosis by inhibiting the TGF-β/Smad2 signaling pathway [1] [2] [3].
T10442 A 83-01 sodium salt

ALK Angiogenesis; Tyrosine Kinase/Adaptors
A 83-01 sodium salt 是一种有效的 TGF-βI 型受体 ALK5，ALK4和 ALK7的抑制剂，抑制 ALK5，ALK4和 ALK7诱导的转录的IC50值分别为 12 nM，45 nM 和 7.5 nM。
T21637 SB-505124 hydrochloride

Others Others
SB-505124 hydrochloride 是TGF-βI 型受体(ALK4，ALK5，ALK7) 的选择性抑制剂，对 ALK4，ALK5 的IC50值分别为 129 nM 和 47 nM，对 ALK1，2，3 或 6 无作用。
T83770 Klotho-derived Peptide 1 (56-87) (human) TFA

KP1 (56-87)
Klotho衍生肽1（KP1）(56-87)是从人类Klotho蛋白质中衍生的肽，具有扰乱TGF-β信号传导的作用。它与TGF-β受体类型1（TGFBR2）和TGF-β受体类型2（TGFBR2；Kds分别为1.41和14.6µM）结合。KP1（10 µg/ml）的预孵育抑制TGF-β在NRK-49F大鼠成纤维细胞中诱导的纤维连接蛋白和α-平滑肌肌动蛋白（α-SMA）水平的增加。在体内，KP1（每天1 mg/kg）选择性地定位于受损的肾脏，并减少血清肌酐和血尿素氮水平，这些是肾功能的标志物，同时也减少了小鼠单侧输尿管阻塞（UUO）和单侧缺血-再灌注损伤诱导的肾脏纤维化模型中的肾纤维化。
T84443 Halofuginone hydrochloride

RU-19110 hydrochloride

 Others Others
Halofuginone hydrobromid (RU-19110)，Febrifugine的衍生物，作为脯氨酰-tRNA合成酶竞争性抑制剂，其Ki值为18.3 nM。该化合物特异性抑制I型胶原合成，并能通过降低TGF-β活性来减轻骨关节炎症状。同时，Halofuginone hydrobromid作为有效的肺血管扩张剂，通过激活Kv通道并阻断电压门控、受体操作与存储操作的Ca2+通道发挥作用。此外，它还具有抗疟疾、抗炎、抗癌及抗纤维化的多重生物活性。

化合物

Ogerin
Cat.No: T16378
Synonym:
Target: Others, 5-HT Receptor, Adenosine Receptor
R-268712
Cat.No: T16708
Synonym:
Target: ALK, TGF-beta/Smad
BIBF0775
Cat.No: T5197
Synonym:
Target: ALK, TGF-beta/Smad
SB-505124
Cat.No: T2462
Synonym:
Target: ALK, TGF-beta/Smad
LY2109761
Cat.No: T2123
Synonym:
Target: Autophagy, TGF-beta/Smad
GW788388
Cat.No: T1800
Synonym: GW 788388
Target: ALK, TGF-beta/Smad
SJ000291942
Cat.No: T4662
Synonym:
Target: TGF-beta/Smad
SM 16
Cat.No: T4975
Synonym:
Target: ALK, TGF-beta/Smad
K02288
Cat.No: T1914
Synonym: K 02288
Target: ALK, TGF-beta/Smad
DMH-1
Cat.No: T1942
Synonym: DMH1
Target: ALK, Autophagy, TGF-beta/Smad
SB 525334
Cat.No: T1763
Synonym: SB525334
Target: ALK, TGF-beta/Smad
ML347
Cat.No: T1943
Synonym: LDN 193719
Target: ALK, TGF-beta/Smad
Galunisertib
Cat.No: T2510
Synonym: LY2157299
Target: TGF-beta/Smad
A 77-01
Cat.No: T2098
Synonym: A77-01
Target: ALK, TGF-beta/Smad
SD-208
Cat.No: T2109
Synonym: ALK5 Inhibitor V,SD208
Target: TGF-beta/Smad
BMS986260
Cat.No: T8730
Synonym:
Target: TGF-beta/Smad
A 83-01
Cat.No: T3031
Synonym: ALK5 Inhibitor IV,A8301
Target: ALK, TGF-beta/Smad
LY3200882
Cat.No: T5125
Synonym:
Target: TGF-beta/Smad
LDN-214117
Cat.No: T1944
Synonym:
Target: ALK, TGF-beta/Smad
LY-364947
Cat.No: T2048
Synonym: LY 364947,HTS466284
Target: MLK, Casein Kinase, TGF-beta/Smad, RIP kinase
LDN193189
Cat.No: T1935
Synonym: LDN-193189,DM-3189,LDN 193189
Target: ALK, TGF-beta/Smad
PD-161570
Cat.No: T23127
Synonym: PD 161570
Target: EGFR, FGFR, PDGFR, Src
BIO-013077-01
Cat.No: T8330
Synonym: 6-(3-(6-甲基吡啶-2-基)-1H-吡唑-4-基)喹噁啉
Target: TGF-beta/Smad
Dorsomorphin
Cat.No: T1977
Synonym: Compound C,BML-275
Target: AMPK, Autophagy, TGF-beta/Smad
BMP signaling agonist sb4
Cat.No: T7799
Synonym: SB 4
Target: TGF-beta/Smad
RepSox
Cat.No: T6337
Synonym: ALK5 Inhibitor II,SJN 2511,E-616452
Target: ALK, TGF-beta/Smad
LDN-212854
Cat.No: T1900
Synonym: LDN212854,BMP Inhibitor III
Target: ALK, TGF-beta/Smad
SB-431542
Cat.No: T1726
Synonym: 4-[4-(1,3-苯并二唑-5-基)-5-(2-吡啶基)-1H-咪唑-2-基]-苯酰胺水合物,SB 431542
Target: ALK, TGF-beta/Smad
ITD-1
Cat.No: T2273
Synonym: 4-[1,1'-联苯]-4-基-1,4,5,6,7,8-六氢-2,7,7-三甲基-5-氧代-3-喹啉羧酸乙酯
Target: TGF-beta/Smad
Vactosertib
Cat.No: T6496
Synonym: TEW-7197,EW-7197
Target: ALK, TGF-beta/Smad
IMM-H007
Cat.No: T9010
Synonym:
Target: Others, AMPK
Dorsomorphin dihydrochloride
Cat.No: T6146
Synonym: BML-275 2HCl,Compound C dihydrochloride,6-[4-[2-(1-哌啶基)乙氧基]苯基]-3-(4-吡啶基)吡唑并[1,5-A]嘧啶,Dorsomorphin (Compound C) 2HCl,Compound C 2HCl,BML-275 dihydrochloride
Target: AMPK, Autophagy, TGF-beta/Smad
CAY10583
Cat.No: T26958
Synonym: CAY 10583,CAY-10583
Target: Others
Sudubrilimab
Cat.No: T77189
Synonym:
Target:
L6H9
Cat.No: T70932
Synonym:
Target: Others
ALK5-IN-6
Cat.No: T63498
Synonym:
Target: Others
J-1048
Cat.No: T78790
Synonym:
Target: Others
ALK5-IN-7
Cat.No: T63114
Synonym:
Target: Others
Butaprost
Cat.No: T26925
Synonym: Butaprostum,TR-4979,(R)-Butaprost
Target: Others
A 83-01 sodium salt
Cat.No: T10442
Synonym:
Target: ALK
SB-505124 hydrochloride
Cat.No: T21637
Synonym:
Target: Others
Klotho-derived Peptide 1 (56-87) (human) TFA
Cat.No: T83770
Synonym: KP1 (56-87)
Target:
Halofuginone hydrochloride
Cat.No: T84443
Synonym: RU-19110 hydrochloride
Target: Others
Cat. No. Product Name Target Signaling Pathways
TN2081 Maohuoside A

MAPK MAPK
Maohuoside A 是从 E. koreanum 中分离出的单一化合物，具有促进成骨作用。它能够利用 MAPK 信号通路骨及形态发生蛋白 (BMP) ，促进骨髓间充质干细胞的成骨作用。

天然产物

Maohuoside A
Cat.No: TN2081
Synonym:
Target: MAPK
Species：
Human (9)
Mouse (5)
Mouse,Rat (2)
Cynomolgus (1)
Human,Mouse,Rat (1)
Expression System：
HEK293 Cells (15)
E. coli (3)
Tag：
Tag Free (5)
C-hFc (4)
C-hFc-6xHis (2)
C-mFc-Avi (2)
N-6xHis (2)
C-6xHis (1)
C-His (1)
C-mFc (1)
Cat. No. Product Name Species Expression System
TMPJ-00335 TGFBR2 Protein, Mouse, Recombinant (His)

TGFR-2,TGF-beta type II receptor,...

 Mouse HEK293 Cells
TGFBR2 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 25-38 KDa and the accession number is Q62312-2.
TMPJ-00333 TGFBR2 Protein, Mouse, Recombinant (aa 24-184, hFc)

Transforming growth factor-β receptor type...

 Mouse HEK293 Cells
TGFBR2 Protein, Mouse, Recombinant (aa 24-184, hFc) is expressed in HEK293 mammalian cells with C-Fc tag. The predicted molecular weight is 60-75 KDa and the accession number is Q62312.
TMPJ-00334 TGFBR2 Protein, Mouse, Recombinant (aa 24-159, hFc)

TGF-β receptor type II,Tgf

Mouse HEK293 Cells
TGFBR2 Protein, Mouse, Recombinant (aa 24-159, hFc) is expressed in HEK293 mammalian cells with C-Fc tag. The predicted molecular weight is 55-65 KDa and the accession number is Q62312-2.
TMPJ-00290 GFR Alpha-2/GFRA2 Protein, Human, Recombinant (hFc & His)

TRNR2,GDNFR-beta,TGF-β-related neurotrophi...

 Human HEK293 Cells
GDNF family receptor alpha-2 is a glycosylphosphatidylinosito l (GPI)-linked cell surface receptor. It is part of the GDNF receptor family. Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. GFRA2 mediates the NRTN-induced autophosphorylation and activation of the RET receptor. It also able to mediate GDNF signaling through the RET tyrosine kina...
TMPJ-01178 TGFBR1 Protein, Mouse, Recombinant (hFc)

ALK-5,ALK-5ALK5,TGFβRI,tβR-I,LDS1...

 Mouse HEK293 Cells
TGF-beta RI, also called ALK-5, is an approximately 55 kDa type I transmembrane serine/threonine receptor kinase. In the presence of TGF-beta, TGF-beta RI forms a complex with, and is phosphorylated by, TGF-beta RII. Phosphorylated TGF-beta RI can then transiently bind and phosphorylate Smad2 and Smad3. TGF-beta functions as a tumor suppressor by inhibiting the cell cycle in the G1 phase. Administration of TGF-beta is able to protect against mammary tumor development in transgenic mouse models i...
TMPJ-00261 TGF beta 2 Protein, Mouse/Rat, Recombinant

transforming growth factor β-2,BSC-1 cell growth in...

 Mouse,Rat HEK293 Cells
Transforming growth factor beta 2 (TGF-β2) is a member of TGF-beta superfamily that shares a characteristic cysteine knot structure. Mice with TGF-β2 gene deletion show defects in development of cardiac, lung, craniofacial, limb, spinal column, eye, inner ear and urogenital systems. All TGF-β isoforms signal via the same heteromeric receptor complex, consisting of a ligand binding TGF-β receptor type II (TβR-II), and a TGF-β receptor type I (TβR-I). Signal transduction from the receptor to the n...
TMPJ-00254 TGF beta 3 Protein, Human/Mouse/Rat, Recombinant

Latency-associated peptide,TGF-beta-3,Transforming ...

 Human,Mouse,Rat HEK293 Cells
Transforming growth factor beta 3(TGFB3) is a member of a TGF -β superfamily which is defined by theirstructural and functional similarities. TGFB3 is secreted as a complex with LAP. This latent form of TGFB3becomes active upon cleavage by plasmin, matrix metalloproteases, thrombospondin -1, and a subset ofintegrins. It binds with high affinity to TGF- β RII, a type II serine/threonine kinase receptor. TGFB3 is involved incell differentiation, embryogenesis and development.It is believed to regu...
TMPJ-00771 TGF beta 1 Protein, Mouse/Rat, Recombinant

TGFB,TGFbeta,CEDLAP,TGF-beta-1,

Mouse,Rat HEK293 Cells
Transforming growth factor beta 1 (TGFβ1) is the prototype of a growing superfamily of peptide growth factors and plays a prominent role in a variety of cellular processes, including cell-cycle progression, cell differentiation, reproductive function, development, motility, adhesion, neuronal growth, bone morphogenesis, wound healing, and immune surveillance. TGF-β1, TGF-β2 and TGF-β3 signal via the same heteromeric receptor complex, consisting of a ligand binding TGF-β receptor type II (TβR-II)...
TMPK-00481 PDGF R beta/CD140b Protein, Cynomolgus, Recombinant (His)

PDGF R beta,PDGFRB,PDGFR-2,PDGF-R-β,PDGF-R-beta,PDG...

 Cynomolgus HEK293 Cells
Platelet-derived growth factor receptor (PDGFR) signaling is involved in proliferation and survival in a wide array of cell types.PDGFR-β signalling, via TGF-β signalling, may be crucial for restoration of BBB integrity after cerebral ischemia and therefore represents a novel potential therapeutic target.
TMPK-00744 LRP-6 Protein, Human, Recombinant (mFc)

DCAD2,LRP-6,FLJ90421,LRP6,FLJ90062

 Human HEK293 Cells
Dickkopf-related protein 1 (DKK-1), a ligand for the WNT coreceptors low-density lipoprotein receptor-related proteins 5 and 6 (LRP-5 and LRP-6) and an inhibitor of WNT/β-catenin signaling, effectively inhibits pericyte activation, detachment, and transition to myofibroblasts in vivo in response to kidney injury, resulting in attenuated fibrogenesis, capillary rarefaction, and inflammation.LRP-6 interacts closely with PDGF receptor β and TGF-β receptor 1 at the cell membrane, suggesting that it ...
TMPK-00329 TGFBR2 Protein, Human, Recombinant (mFc & Avi), Biotinylated

LDS2B,TbetaR-II,TGFβR2,LDS2,RIIC,TGF

Human HEK293 Cells
The TGFBR2 gene provides instructions for making a protein called transforming growth factor-beta (TGF-β) receptor type 2. This receptor transmits signals from the cell surface into the cell through a process called signal transduction. Through this type of signaling, the environment outside the cell affects activities inside the cell such as stimulation of cell growth and division. TGFBR2 Protein, Human, Recombinant (mFc & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-mFc-Avi...
TMPK-00328 TGFBR2 Protein, Human, Recombinant (mFc & Avi)

TAAD2,LDS2B,LDS2,MFS2,TGFBR2,AAT3,LDS1B,TGF

Human HEK293 Cells
The TGFBR2 gene provides instructions for making a protein called transforming growth factor-beta (TGF-β) receptor type 2. This receptor transmits signals from the cell surface into the cell through a process called signal transduction. Through this type of signaling, the environment outside the cell affects activities inside the cell such as stimulation of cell growth and division. TGFBR2 Protein, Human, Recombinant (mFc & Avi) is expressed in HEK293 mammalian cells with C-mFc-Avi tag. The pred...
TMPJ-00238 Lefty-A Protein, Human, Recombinant (His)

Endometrial bleeding-associated factor,TGFB4,TG...

 Human HEK293 Cells
Left-right determination factor 2(LEFTY2) is a secreted protein which belongs to the TGF-beta family. Lefty was first identified in a screen for undifferentiated cell-specific cDNAs from the P19 mouse embryonal carcinoma cells. Its mRNA expression on the left side of the developing embryo earned the name “Lefty”. The human orthologue was initially identified as Ebaf, Endometrial bleeding associated factor. Lefty contains the six cysteine residues that are conserved among TGF-β related proteins a...
TMPJ-00314 ACVR2B Protein, Human, Recombinant (hFc & His)

ACVR2B,Activin Receptor Type IIB,ACTR-IIB,Activin <...

 Human HEK293 Cells
Activin proteins that belong to the transforming growth factor-beta (TGF-β) superfamily, exert their biological actions by binding to heteromeric receptor complexes of type I and type II serine/threonine kinase receptors. On ligand binding, type I and II receptors form a stable complex, resulting in phosphorylation of type I receptors by type II receptors with constitutive kinase activity, and subsequently initiates the activation of downstream molecules including the endogenous Smads. ActRIIB, ...
TMPJ-00100 Artemin Protein, Human, Recombinant

ARTN,Artemin,EVN,Enovin,Neublastin

 Human E. coli
Human Artemin is a GDNF family ligand that is distantly related to the TGF-β superfamily of molecules. It is synthesized as a preproprotein, and contains a variable length pre-, or signal sequence, plus a 68 amino acid (aa) proregion and a 113 aa mature segment. Following synthesis and proteolytic processing, mature ARTN is secreted as a presumably glycosylated, 28 kDa disulfide-linked homodimer that contains three intrachain disulfide bonds and the typical TGF-β signature cysteine-knot motif. I...
TMPJ-00304 ALK-1 Protein, Mouse, Recombinant (hFc)

TSR-I,Serine/threonine-protein kinase receptor R3,A...

 Mouse HEK293 Cells
Activin Receptor-Like Kinase 1 (ALK-1) is a type I cell-surface receptor for the TGF-β superfamily of ligands, which mediates signaling of BMP9 (bone morphogenetic protein) and BMP10. ALK1 signaling is necessary for angiogenesis during embryogenesis, wound healing, and tumor growth. ALK-1 has a high degree of similarity in serine-threonine kinase subdomains, a glycine and serine rich region preceding the kinase-domain, and a C-terminal tail with other activin receptor-like kinase proteins. ALK-1...
TMPJ-00688 Persephin Protein, Human, Recombinant

PSPN,Persephin,PSP

 Human E. coli
Persephin is a secreted protein, belongs to the glial cell linederived neurotrophic factor (GDNF) family of the TGF-β superfamily. It shares 38-46% amino acid (aa) identity with family members GDNF, neurturin and artemin. It is expressed at very low levels in most tissues. Mature protein contains a signal sequence, a pro-domain and a 96 aa mature sequence with several cysteines that are conserved among family members. It circulates as an unglycosylated disulfide-linked homodimer. Like other GDNF...
TMPJ-01290 Neurturin Protein, Human, Recombinant

Neurturin,NRTN

 Human E. coli
Neurturin is a member of the GDNF family of ligands, which include glial cell-derived neurotrophic factor (GDNF), Neurturin, Persephin, and Artemin. Neurturin is expressed in both neuronal and nonneuronal tissues. Similarly to other TGFβ family proteins, Neurturin is synthesized as a precursor protein that is cleaved at the dibasic cleavage site (RXXR) to release the carboxyterminal domain. The carboxy terminal domain of Neurturin contains the characteristic seven conserved cysteine residues nec...

重组蛋白

TGFBR2 Protein, Mouse, Recombinant (His)
Cat.No: TMPJ-00335
Species: Mouse
Expression System: HEK293 Cells
TGFBR2 Protein, Mouse, Recombinant (aa 24-184, hFc)
Cat.No: TMPJ-00333
Species: Mouse
Expression System: HEK293 Cells
TGFBR2 Protein, Mouse, Recombinant (aa 24-159, hFc)
Cat.No: TMPJ-00334
Species: Mouse
Expression System: HEK293 Cells
GFR Alpha-2/GFRA2 Protein, Human, Recombinant (hFc & His)
Cat.No: TMPJ-00290
Species: Human
Expression System: HEK293 Cells
TGFBR1 Protein, Mouse, Recombinant (hFc)
Cat.No: TMPJ-01178
Species: Mouse
Expression System: HEK293 Cells
TGF beta 2 Protein, Mouse/Rat, Recombinant
Cat.No: TMPJ-00261
Species: Mouse,Rat
Expression System: HEK293 Cells
TGF beta 3 Protein, Human/Mouse/Rat, Recombinant
Cat.No: TMPJ-00254
Species: Human,Mouse,Rat
Expression System: HEK293 Cells
TGF beta 1 Protein, Mouse/Rat, Recombinant
Cat.No: TMPJ-00771
Species: Mouse,Rat
Expression System: HEK293 Cells
PDGF R beta/CD140b Protein, Cynomolgus, Recombinant (His)
Cat.No: TMPK-00481
Species: Cynomolgus
Expression System: HEK293 Cells
LRP-6 Protein, Human, Recombinant (mFc)
Cat.No: TMPK-00744
Species: Human
Expression System: HEK293 Cells
TGFBR2 Protein, Human, Recombinant (mFc & Avi), Biotinylated
Cat.No: TMPK-00329
Species: Human
Expression System: HEK293 Cells
TGFBR2 Protein, Human, Recombinant (mFc & Avi)
Cat.No: TMPK-00328
Species: Human
Expression System: HEK293 Cells
Lefty-A Protein, Human, Recombinant (His)
Cat.No: TMPJ-00238
Species: Human
Expression System: HEK293 Cells
ACVR2B Protein, Human, Recombinant (hFc & His)
Cat.No: TMPJ-00314
Species: Human
Expression System: HEK293 Cells
Artemin Protein, Human, Recombinant
Cat.No: TMPJ-00100
Species: Human
Expression System: E. coli
ALK-1 Protein, Mouse, Recombinant (hFc)
Cat.No: TMPJ-00304
Species: Mouse
Expression System: HEK293 Cells
Persephin Protein, Human, Recombinant
Cat.No: TMPJ-00688
Species: Human
Expression System: E. coli
Neurturin Protein, Human, Recombinant
Cat.No: TMPJ-01290
Species: Human
Expression System: E. coli
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