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Search Results for " pregnenolone "

Targets Recommended: P450

6

抑制剂 & 化合物

6

天然产物

5

重组蛋白

3

同位素标记化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T21818	Pregnenolone Carbonitrile Pregnenolone 16α-carbonitrile ,5-Pregnen-3β-ol-20-one-16α-carbonitrile	P450	Metabolism
	Pregnenolone Carbonitrile (5-Pregnen-3β-ol-20-one-16α-carbonitrile) 是一种啮齿动物-PXR 的激活剂，可诱导 CYP3A 的表达。
T29877	Allantoin pregnenolone acetate	Others	Others
	Allantoin pregnenolone acetate is a biochemical.
T9504	MAP4343	Microtubule Associated	Cytoskeletal Signaling
	MAP4343 是孕烯醇酮的 3-甲基醚衍生物。它在体外与微管相关蛋白 2 (MAP2) 结合并刺激微管蛋白聚合，从而增强神经突延伸和保护神经元免受神经毒剂的侵害。
T3219	16,17-Epoxypregnenolone acetate 16alpha,17alpha-Epoxypregnenolone acetate,16,17-环氧孕烯醇酮醋酸酯	Others	Others
	16,17-Epoxypregnenolone acetate (16alpha,17alpha-Epoxypregnenolone acetate) 可由洋葱伯克霍尔德菌 SE-1 生产。
T3225	16,17-Epoxy-21-acetoxypregnenolone	Others	Others
	16,17-Epoxy-21-acetoxypregnenolone 用作药物中间体。
T67098	16-Dehydropregnenolone Acetate	Others	Others
	16-Dehydropregnenolone Acetate 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T67098，CAS号为 979-02-2。

化合物

Pregnenolone Carbonitrile

Cat.No: T21818

Synonym: Pregnenolone 16α-carbonitrile ,5-Pregnen-3β-ol-20-one-16α-carbonitrile

Target: P450

Allantoin pregnenolone acetate

Cat.No: T29877

Target: Others

Cat.No: T9504

Target: Microtubule Associated

16,17-Epoxypregnenolone acetate

Cat.No: T3219

Synonym: 16alpha,17alpha-Epoxypregnenolone acetate,16,17-环氧孕烯醇酮醋酸酯

Target: Others

16,17-Epoxy-21-acetoxypregnenolone

Cat.No: T3225

Target: Others

16-Dehydropregnenolone Acetate

Cat.No: T67098

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T0851	Pregnenolone 3β-Hydroxy-5-pregnen-20-one,Arthenolone,孕烯醇酮	Cannabinoid Receptor; Endogenous Metabolite; TRP/TRPV Channel; AChR; Autophagy	Autophagy; GPCR/G Protein; Membrane transporter/Ion channel; Metabolism; Neuroscience
	Pregnenolone (Arthenolone) 是一种由胆固醇合成的内源性类固醇激素，用于治疗阿尔茨海默病。它是大麻素 CB1受体的信号传导特异性抑制剂，抑制由 CB1受体介导的四氢大麻酚的作用。它也是 TRPM3通道激活剂，也可弱激活 TRPM1通道。
TC0019	Pregnenolone acetate 孕烯醇酮醋酸酯,3β-Hydroxy-5-pregnen-20-one acetate	Cannabinoid Receptor; Endogenous Metabolite	GPCR/G Protein; Metabolism
	Pregnenolone acetate 是一种强大的神经类固醇，是各种类固醇激素（包括类固醇酮）的主要前体。它作为大麻素 CB1 受体的信号特异性抑制剂，抑制由 CB1 受体介导的四氢大麻酚 (THC) 的作用。它可以保护大脑免受大麻中毒。
T12536	Pregnenolone monosulfate 3β-Hydroxy-5-pregnen-20-one monosulfate	NMDAR	Neuroscience
	Pregnenolone monosulfate (3β-Hydroxy-5-pregnen-20-one monosulfate) 是一种强效神经类固醇，可正向调节 NMDA 记录,可用于研究神经分裂和抑郁症。
T16574	Pregnenolone monosulfate sodium salt 3β-Hydroxy-5-pregnen-20-one monosulfate sodium salt	Others	Others
	Pregnenolone monosulfate sodium salt is a powerful neurosteroid, the main precursor of various steroid hormones including steroid ketones. Pregnenolone monosulfate sodium salt can protect the brain from cannabis intoxication. Pregnenolone monosulfate sodi
T10048	17a-Hydroxypregnenolone	Endogenous Metabolite	Metabolism
	17a-Hydroxypregnenolone 是一种孕烷类固醇, 是形成脱氢表雄酮的激素原。17a-Hydroxypregnenolone 是一种神经调节剂。
T13489	21-Hydroxypregnenolone	Others	Others
	21-Hydroxypregnenolone is an essential intermediate in corticosterone synthesis.

天然产物

Cat.No: T0851

Synonym: 3β-Hydroxy-5-pregnen-20-one,Arthenolone,孕烯醇酮

Target: Cannabinoid Receptor, Endogenous Metabolite, TRP/TRPV Channel, AChR, Autophagy

Pregnenolone acetate

Cat.No: TC0019

Synonym: 孕烯醇酮醋酸酯,3β-Hydroxy-5-pregnen-20-one acetate

Target: Cannabinoid Receptor, Endogenous Metabolite

Pregnenolone monosulfate

Cat.No: T12536

Synonym: 3β-Hydroxy-5-pregnen-20-one monosulfate

Target: NMDAR

Pregnenolone monosulfate sodium salt

Cat.No: T16574

Synonym: 3β-Hydroxy-5-pregnen-20-one monosulfate sodium salt

Target: Others

17a-Hydroxypregnenolone

Cat.No: T10048

Target: Endogenous Metabolite

21-Hydroxypregnenolone

Cat.No: T13489

Target: Others

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPH-02139	CYP17A1 Protein, Human, Recombinant (GST) Cytochrome P450 17A1,CYPXVII,CYP17A1,CYP17,S17AH,Cytochrome ...	Human	E. coli
	A cytochrome P450 monooxygenase involved in corticoid and androgen biosynthesis. Catalyzes 17-alpha hydroxylation of C21 steroids, which is common for both pathways. A second oxidative step, required only for androgen synthesis, involves an acyl-carbon cleavage. The 17-alpha hydroxy intermediates, as part of adrenal glucocorticoids biosynthesis pathway, are precursors of cortisol (Probable). Hydroxylates steroid hormones, pregnenolone and progesterone to form 17-alpha hydroxy metabolites, follow...
TMPH-00220	Adrenodoxin, mitochondrial Protein, Bovine, Recombinant (His) Hepato-ferredoxin,FDX1,Ferredoxin-1,Adrenodoxin, mitochondri...	Bovine	E. coli
	Essential for the synthesis of various steroid hormones. Participates in the reduction of mitochondrial cytochrome P450 for steroidogenesis. Transfers electrons from adrenodoxin reductase to CYP11A1, a cytochrome P450 that catalyzes cholesterol side-chain cleavage to produce pregnenolone, the precursor of most steroid hormones. Does not form a ternary complex with adrenodoxin reductase and CYP11A1 but shuttles between the two enzymes to transfer electrons. Adrenodoxin, mitochondrial Protein, Bov...
TMPY-01660	SULT1E1 Protein, Human, Recombinant (His) ST1E1,EST,sulfotransferase family 1E member 1,EST-1,STE,MGC3...	Human	E. coli
	Estrogen sulfotransferase, also known as Sulfotransferase, estrogen-preferring, Sulfotransferase 1E1, SULT1E1 and ST1E1, is a cytoplasm enzyme that belongs to the sulfotransferase 1 family. Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. SULT1E1 may control the level of the estrogen receptor by sulfurylating free estradio...
TMPY-01616	SULT2B1 Protein, Human, Recombinant (His) SULT2B1,sulfotransferase family 2B member 1,HSST2	Human	E. coli
	Sulfotransferase family cytosolic 2B member 1, also known as Sulfotransferase 2B1, ST2B1, Alcohol sulfotransferase, Hydroxysteroid sulfotransferase 2, SULT2B1 and HSST2, is a cytoplasm protein that belongs to the sulfotransferase 1 family. The human hydroxysteroid sulfotransferase (SULT) family is comprised of two subfamilies, SULT2A1 and SULT2B1. SULT2B1 is expressed highly in placenta, prostate and trachea. A lesser expression of SULT1B1 was observed in the small intestine and lung. SULT2B1 ca...
TMPY-01587	SULT2A1 Protein, Human, Recombinant (His) hSTa,HST,ST2,ST2A1,STD,DHEAS,ST2A3,sulfotransferase family, ...	Human	E. coli
	Hydroxysteroid sulfotransferase ( SULT2A1 ) is a key enzyme in the testicular and hepatic metabolism of 5alpha-androstenone, which is a major component of the off-odor and off-flavor in pork known as boar taint. Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar amon...

重组蛋白

CYP17A1 Protein, Human, Recombinant (GST)

Cat.No: TMPH-02139

Species: Human

Expression System: E. coli

Adrenodoxin, mitochondrial Protein, Bovine, Recombinant (His)

Cat.No: TMPH-00220

Species: Bovine

Expression System: E. coli

SULT1E1 Protein, Human, Recombinant (His)

Cat.No: TMPY-01660

Species: Human

Expression System: E. coli

SULT2B1 Protein, Human, Recombinant (His)

Cat.No: TMPY-01616

Species: Human

Expression System: E. coli

SULT2A1 Protein, Human, Recombinant (His)

Cat.No: TMPY-01587

Species: Human

Expression System: E. coli

Cat. No.	Product Name	Target	Signaling Pathways
TMID-0137	Pregnenolone-d4
	Pregnenolone-d4 是 Pregnenolone 的氘代化合物。Pregnenolone 的 CAS 号为 145-13-1。Pregnenolone 是一种由胆固醇合成的内源性类固醇激素，用于治疗阿尔茨海默病。它是大麻素CB1受体的信号传导特异性抑制剂，抑制由CB1受体介导的四氢大麻酚的作用。它也是TRPM3通道激活剂，也可弱激活TRPM1通道。
TMID-0138	Sodium Pregnenolone-17α,21,21,21-d4 Sulfate
	Sodium Pregnenolone-17α,21,21,21-d4 Sulfate 是 Sodium Pregnenolone Sulfate 的氘代化合物。
TMID-0147	17a-Hydroxypregnenolone-d3
	17a-Hydroxypregnenolone-d3 是 17a-Hydroxypregnenolone 的氘代化合物。17a-Hydroxypregnenolone 的 CAS 号为 387-79-1。17a-Hydroxypregnenolone 是一种孕烷类固醇, 是形成脱氢表雄酮的激素原。17a-Hydroxypregnenolone 是一种神经调节剂。

同位素标记化合物

Pregnenolone-d4

Cat.No: TMID-0137

Sodium Pregnenolone-17α,21,21,21-d4 Sulfate

Cat.No: TMID-0138

17a-Hydroxypregnenolone-d3

Cat.No: TMID-0147

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