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Search Results for " central nervous system diseases "

Targets Recommended: PDE

13

抑制剂 & 化合物

6

化合物库

4

重组蛋白

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Cat. No.	Product Name
L7700	神经再生化合物库		524 compounds
	524 种神经再生相关化合物的独特集合，可用于高通量筛选和高内涵筛选；
L2620	神经退行性疾病化合物库		2154 compounds
	2154 种与神经退行性疾病相关的化合物，可用于高通量和高内涵筛选；
L3300	组胺&褪黑色素化合物库		153 compounds
	153 种生物活性小分子化合物，用于高通量、高内涵筛选；
L5900	血脑屏障通透化合物库		509 compounds
	509 个 CNS-Penetrant 生物活性小分子化合物的特有集合，用于高通量、高内涵筛选；
L2610	神经递质受体化合物库		1513 compounds
	1513 种与神经递质受体相关的化合物，用于高通量、高内涵筛选；
L4300	Wnt/Hedgehog/Notch 通路化合物库		237 compounds
	237 个Wnt & Hedgehog & Notch 靶点相关的生物活性小分子化合物的特有集合，用于相关通路的研究及药物的筛选，可用于高通量、高内涵筛选。

化合物库

神经再生化合物库

Cat.No: L7700

Compounds: 524

神经退行性疾病化合物库

Cat.No: L2620

Compounds: 2154

组胺&褪黑色素化合物库

Cat.No: L3300

Compounds: 153

血脑屏障通透化合物库

Cat.No: L5900

Compounds: 509

神经递质受体化合物库

Cat.No: L2610

Compounds: 1513

Wnt/Hedgehog/Notch 通路化合物库

Cat.No: L4300

Compounds: 237

Cat. No.	Product Name	Target	Signaling Pathways
T28352	PDE9-IN-(S)-C33 (S)-C33	PDE	Metabolism
	PDE9-IN-(S)-C33 ((S)-C33) 是一种有效的选择性 PDE9 抑制剂 (IC50 = 11 nM)。 PDE9-IN-(S)-C33 可用于中枢神经系统疾病和糖尿病的相关研究。
T68079	Gedocarnil ZK 113315,SH 530	Others	Others
	Gedocarnil（ZK 113315）可用于研究中枢神经系统疾病。
T10881	CPPHA	GluR	Neuroscience
	CPPHA 是一种谷氨酸受体 mGluR5 和 mGluR1的正向变构调制剂，常用于开发用于中枢神经系统疾病。
T9687	MAGL-IN-4 His121 ARG57	Lipase	Metabolism
	MAGL-IN-4 (His121 ARG57) 是选择性的、口服有效的、可透过血脑屏障的、可逆的单酰基甘油脂肪酶抑制剂，IC50=6.2 nM。它主要通过大脑中选择性抑制 MAGL 增加 2-花生四烯酰甘油水平来增强内源性大麻素信号。
T67879	hMAO-B-IN-5	MAO; Monoamine Oxidase	Metabolism; Neuroscience
	hMAO-B-IN-5 是有一种有效的、可逆的、具有选择性的人类单胺氧化酶 hMAO-B 抑制剂（ IC50 ：0.12 μM）。 hMAO-B-IN-5 可以透过血脑屏障，可用于对帕金森疾病的研究，是中枢神经系统疾病的治疗和诊断中都是有潜力的化合物。
T9729	AGI-43192	Others	Others
	AGI-43192是一种有效的，可渗透进血脑屏障的蛋氨酸腺苷转移酶 2A (MAT2A) 抑制剂。AGI-43192抑制 s -腺苷蛋氨酸(SAM)生成代谢酶和蛋氨酸腺苷转移酶2A (MAT2A)，具有研究 SAM 调节在中枢神经系统 (CNS) 中的作用和治疗癌症疾病的潜力。
T23440	TC-N 22A	GluR	Neuroscience
	TC-N 22A 是一种作用力强的、可选择的、口服具有活性的、可以通过血脑屏障的 mGlu4 正向别构调节剂 (PAM)。TC-N 22A 在表达人 mGlu4 的 BHK 细胞中 EC50 表现为 9 nM。TC-N 22A 在激动和正向别构模型中对 mGlu 1、2、3、5 和 7 受体的活性表现很低 (EC50 >10 μM)。TC-N 22A 可以用于中枢神经系统疾病的研究。
T10121	Substance P Receptor Antagonist 1	Others	Others
	Substance P Receptor Antagonist 1 has the potential function in gastrointestinal disorders, inflammatory diseases, respiratory, and central nervous system disorders.
T79212	mTOR inhibitor-12	mTOR	PI3K/Akt/mTOR signaling
	mTORinhibitor-12（Compound 11）为选择性脑渗透性mTOR抑制剂，无遗传毒性风险，适用于中枢神经系统疾病研究。
T36813	Lu AE98134	Others	Others
	Lu AE98134, an activator of voltage-gated sodium channels, acts as a partly selective Nav1.1 channels positive modulator. Lu AE98134 also increases the activity of Nav1.2 and Nav1.5 channels but not of Nav1.4, Nav1.6 and Nav1.7 channels. Lu AE98134 can be used to analyze pathophysiological functions of the Nav1.1 channel in various central nervous system diseases, including cognitive restoring in schizophrenia, et al[1].
T62517	S1p receptor agonist 2	Others	Others
	S1p receptor agonist 2 (compound 1) 是一种 S1P5 受体的激动剂，选择性比 S1P1 和/或 S1P3 受体高。S1p receptor agonist 2 能够用于内源性 SIP 信号系统，以及减轻/预防中枢神经系统 (CNS) 疾病 (如神经退行性疾病) 的演技。
T62511	AZ3391	Others	Others
	AZ3391 是一种喹喔啉衍生物，是一种 PARP 的有效抑制剂。其中 PARP 酶家族在许多细胞过程中具有重要作用（如复制、重组、染色质重塑和 DNA 损伤修复）。AZ3391 具有潜力进行中枢神经系统组织中发生的疾病和病症的研究（如大脑和脊髓）。
T61607	Laquinimod sodium	Others	Others
	Laquinimod (ABR-215062) sodium 是一种可口服的羧酰胺衍生物，是一种有效的免疫调节剂，可防止中枢神经系统的神经变性和炎症。Laquinimod sodium 减少星形胶质细胞NF-κB 的活化以防止铜酮 (Cuprizone) 诱导的脱髓鞘。Laquinimod sodium 具有用于多发性硬化症 (MS；RRMS 或 CPMS) 的复发缓解 (RR) 和慢性进行性 (CP) 形式以及神经退行性疾病研究的潜力。

化合物

PDE9-IN-(S)-C33

Cat.No: T28352

Synonym: (S)-C33

Target: PDE

Cat.No: T68079

Synonym: ZK 113315,SH 530

Target: Others

Cat.No: T10881

Target: GluR

Cat.No: T9687

Synonym: His121 ARG57

Target: Lipase

Cat.No: T67879

Target: MAO, Monoamine Oxidase

Cat.No: T9729

Target: Others

Cat.No: T23440

Target: GluR

Substance P Receptor Antagonist 1

Cat.No: T10121

Target: Others

mTOR inhibitor-12

Cat.No: T79212

Target: mTOR

Cat.No: T36813

Target: Others

S1p receptor agonist 2

Cat.No: T62517

Target: Others

Cat.No: T62511

Target: Others

Laquinimod sodium

Cat.No: T61607

Target: Others

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-00561	Neurotensin Protein, Human, Recombinant (hFc) NMN-125,NTS1,NN,NT/N,neurotensin,NT	Human	HEK293 Cells
	NTS (Neurotensin) is a Protein Coding gene. This gene encodes a common precursor for two peptides, neuromedin N and neurotensin. NTS is a neuropeptide distributed in the central nervous and digestive systems. It belongs to the neurotensin family. NTS is an endogenous tridecapeptide of the central nervous system and the gastrointestinal tract of different mammalian species including the human. The human gene encoding neurotensin has previously been assigned to chromosome 12 but no regional locali...
TMPY-03445	Aspartate Aminotransferase Protein, Human, Recombinant (His) ASTQTL1,glutamic-oxaloacetic transaminase 1, soluble,cCAT,cA...	Human	E. coli
	GOT1 (Glutamic-Oxaloacetic Transaminase 1) is a Protein Coding gene. GOT1 belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. Glutamic-oxaloacetic transaminase is a pyridoxal phosphate-dependent enzyme that exists in cytoplasmic and mitochondrial forms, GOT1 and GOT2, respectively. GOT plays a role in amino acid metabolism and the urea and tricarboxylic acid cycles. The two enzymes are homodimeric and show close homology. GOT1 is an important regulator of levels of glut...
TMPY-02717	GPR37 Protein, Human, Recombinant (His) hET(B)R-LP,PAELR,G protein-coupled receptor 37 (endothelin r...	Human	HEK293 Cells
	GPR37 (cathepsin Z) is an orphan receptor that belongs to the G-protein coupled receptor 1 family. G protein-coupled receptors are a large protein family comprised of transmembrane receptors that sense molecules outside the cell and activate inside signal transduction pathways and, ultimately, cellular responses. They only exist in eukaryotes, including yeast, choanoflagellates, and animals. These receptors are bonded and activated by light-sensitive compounds, odors, pheromones, hormones, and n...
TMPJ-00332	tPA Protein, Human, Recombinant (His) TPA,T-PA,t-plasminogen activator,Tissue plasminogen activato...	Human	HEK293 Cells
	Tissue-type plasminogen activator (PLAT) is a protein that secreted into extracellular space. PLAT contains five domains: EGF-like domain, fibronectin type-I domain, 2 kringle domains and peptidase S1 domain. It belongs to the peptidase S1 family. The main function of this protein is to convert plasminogen into biologically active plasmin. As a protease, PLAT plays a crucial role in regulating blood fibrinolysis, maintaining the homeostasis of extracellular matrix and in modulating the post-tra...

重组蛋白

Neurotensin Protein, Human, Recombinant (hFc)

Cat.No: TMPY-00561

Species: Human

Expression System: HEK293 Cells

Aspartate Aminotransferase Protein, Human, Recombinant (His)

Cat.No: TMPY-03445

Species: Human

Expression System: E. coli

GPR37 Protein, Human, Recombinant (His)

Cat.No: TMPY-02717

Species: Human

Expression System: HEK293 Cells

tPA Protein, Human, Recombinant (His)

Cat.No: TMPJ-00332

Species: Human

Expression System: HEK293 Cells

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