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Search Results for " adenosine kinase "

Targets Recommended: Others

24

抑制剂 & 化合物

2

天然产物

2

化合物库

2

重组蛋白

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Cat. No.	Product Name
L1120	AMPK靶向分子库		80 compounds
	80 个靶向AMPK 的分子集合，可用于高通量和高内涵筛选；
L7700	神经再生化合物库		524 compounds
	524 种神经再生相关化合物的独特集合，可用于高通量筛选和高内涵筛选；

化合物库

AMPK靶向分子库

Cat.No: L1120

Compounds: 80

神经再生化合物库

Cat.No: L7700

Compounds: 524

Cat. No.	Product Name	Target	Signaling Pathways
T22554	Adenosine Kinase Inhibitor (hydrate)	Others	Others
	Adenosine kinase is the key metabolizing enzyme regulating cellular adenosine concentrations. Inhibition of adenosine kinase can selectively enhance the protective actions of adenosine during tissue trauma without producing the nonspecific effects associa
T14944	CGS 15943	PI3K; Adenosine Receptor	GPCR/G Protein; Neuroscience; PI3K/Akt/mTOR signaling
	CGS 15943 是一种可口服的非黄嘌呤腺苷受体拮抗剂。在转染的 CHO 细胞中，其对人 A1、A2A、A2B 和 A3 腺苷受体的 Ki 分别为 3.5、4.2、16 和 50 nM。
T4668	ABT-702 dihydrochloride	Adenosine Receptor	GPCR/G Protein; Neuroscience
	ABT-702 dihydrochloride 是腺苷激酶抑制剂，IC50为1.7 nM。
T84880	ABT-702 hydrochloride Adenosine Kinase Inhibitor hydrochloride	Others	Others
	ABT-702 hydrochloride，一种有效的腺苷激酶 (AK) 抑制剂，其IC50值为1.7 nM。
T6745	5-Iodotubercidin 5-碘代杀结核菌素,5-ITu,NSC 113939	Adenosine Receptor	GPCR/G Protein; Neuroscience
	5-Iodotubercidin (NSC-113939) 是一种 ATP 类似物，有效抑制腺苷激酶，IC50为 26 nM。它可以激活磷酸化酶和糖原合成酶，在离体肝细胞中启动糖原合成。它也抑制 CK1、胰岛素受体酪氨酸激酶、磷酸化酶激酶、PKA、CK2、PKC 和 Haspin 。
T21017	5'-Amino-5'-deoxyadenosine 5' Amino 5' deoxyadenosine,5'Amino5'deoxyadenosine,Nsc 238990,NH2dAdo	Apoptosis; Adenosine Receptor	Apoptosis; GPCR/G Protein; Neuroscience
	5'-Amino-5'-deoxyadenosine (NH2dAdo) 是一种针对惰性淋巴系统恶性肿瘤的腺苷激酶抑制剂，具有抗肿瘤和抗癌作用。5'-Amino-5'-deoxyadenosine 的抗癌机制通过抑制 DNA 合成，诱导细胞凋亡 (apoptosis) 等来实现。
T2615	Flavopiridol hydrochloride Alvocidib Hydrochloride,NSC 649890,MDL 107826A,HL 275,FLAVOPIRIDOL HCL,NSC 649890 HCl	HIV Protease; CDK; Autophagy	Autophagy; Cell Cycle/Checkpoint; Microbiology/Virology; Proteases/Proteasome
	Flavopiridol hydrochloride (MDL 107826A) 是一种CDK 的广谱抑制剂，与 ATP 竞争性地抑制 CDK1，CDK2 和 CDK4 的活性，IC50值分别为 30, 170, 100 nM。
T1433	Ritodrine hydrochloride DU21220,盐酸利托君,Ritodrine HCl,NSC 291565	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Ritodrine hydrochloride (NSC 291565) 是一种 β-2肾上腺素受体激动剂。
T21018	Anisodine hydrobromide	Others	Others
	5'-Amino-5'-deoxyadenosine is an inhibitor of adenosine kinase.
T25145	Benzoadenosine NSC 287022,NSC287022,NSC-287022,Lin-benzoadenosine	Others	Others
	Benzoadenosine suppresses kinase activity slightly less than does adenosine.
T38346	ABT 702 hydrochloride	Others	Others
	Potent non-nucleoside adenosine kinase inhibitor (IC50 = 1.7 nM), selective over other sites of adenosine interaction (A1, A2A and A3 receptors, adenosine transporter and adenosine deaminase). Displays oral activity in animal models of pain and inflammation.
T70617	GP-1-515	Others	Others
	GP-1-515 is an adenosine kinase inhibitor with anti-inflammatory effects.
TP1314	AMARA peptide TFA (163560-19-8 free base) AMARA peptide TFA
	AMARA peptide (TFA) is a substrate for salt-induced kinase (SIK) and adenosine activated protein kinase (AMPK).
T26475	A-286501	Others	Others
	A-286501 is an orally active adenosine kinase inhibitor (IC50=0.47 nM). A-286501 effectively attenuates nociception by a non-opioid, non-non-steroidal anti-inflammatory drug ADO, receptor mediated mechanism.
T35574	Adenosine 5'-phosphosulfate (sodium salt)	Others	Others
	Adenosine 5'-phosphosulfate is an ATP and sulfate competitive inhibitor of ATP sulfurylase in humans, S. cerevisiae, and P. chrysogenum (Ki = 18, 2500, and 1500 nM, respectively). Adenosine 5'-phosphosulfate also inhibits human adenosine 5'-phosphosulfate kinase (Ki = 47.5 μM) to prevent sulfation.
T75984	AMARA peptide TFA
	AMARA peptide (TFA) 是盐诱导激酶 (SIK) 和腺苷酸活化蛋白激酶 (AMPK) 的底物。
T62227	GP3269	Others	Others
	GP3269 是一种选择性的、有效的、口服具有活力的人腺苷激酶 (AK) 抑制剂 (IC50: 11 nM)，在大鼠中具有抗惊厥作用。
T68267	RO5068760	Others	Others
	RO5068760 , a substituted hydantoin, is a potent, highly selective, non-adenosine triphosphate (ATP)-competitive MEK1/2 inhibitors. RO5068760 shows significant efficacy in a broad spectrum of tumors with aberrant mitogen-activated protein kinase pathway activation. In vitro, RO5068760 demonstrates MEK1 kinase inhibitory activity with an IC50 of 0.025 μM in a cRaf/MEK/ERK cascade assay RO5068760 showed superior efficacy in tumors harboring B-RafV600E mutation.
T74033	6-Me-ATP	Others	Others
	6-Me-ATP（N6-Methyl-ATP）为ATP的N6修饰衍生物。该化合物与GSK3β结合亲和力显著，能有效作为GSK3β催化底物肽磷酸化的磷酸基团供体。
T73525	ML202	Others	Others
	ML202作为一种变构激活剂，针对人丙酮酸激酶M2 (hPK-M2)展现出高度特异性，能够影响磷酸烯醇丙酮酸(PEP)结合的协同性，而对二磷酸腺苷(ADP)的结合几乎无影响。
T83805	Rp-Adenosine-5'-O-(1-thiodiphosphate) sodium Rp-ADP-α-S	Others	Others
	Rp-Adenosine-5'-O-(1-thiodiphosphate)（Rp-ADP-α-S）是ADP-α-S的含硫异构体，是磷酸化酶激酶的抑制剂（Ki = 0.53 µM）。此化合物能诱导分离的人类血小板聚集（EC50 = 20 µM），并能引发经卡巴胆碱预收缩的豚鼠乙状结肠松弛（EC50 = 58.9 µM）。
T83806	Sp-Adenosine-5'-O-(1-thiodiphosphate) sodium Sp-ADP-α-S	Others	Others
	Sp-Adenosine-5’-O-(1-thiodiphosphate) (Sp-ADP-α-S) 是硫含量核苷酸衍生物ADP-α-S的一种异构体。它是磷酸化酶激酶的抑制剂（Ki = 0.53 µM）。Sp-ADP-α-S能引起人类孤立血小板聚集（EC50 = 20 µM），并能使羧胺胆碱预收缩的豚鼠taenia coli松弛（EC50 = 58.9 µM）。
T68581	AP23464	Others	Others
	AP23464 is a potent adenosine 5'-triphosphate (ATP)-based inhibitor of Src and Abl kinases, displays antiproliferative activity against a human CML cell line and Bcr-Abl-transduced Ba/F3 cells (IC(50) = 14 nM. AP23464 ablates Bcr-Abl tyrosine phosphorylation, blocks cell cycle progression, and promotes apoptosis of Bcr-Abl-expressing cells. Biochemical assays with purified glutathione S transferase (GST)-Abl kinase domain confirmed that AP23464 directly inhibits Abl activity. Importantly, the lo...
T36679	Rp-cAMPS sodium salt	Others	Others
	Rp-cAMPS sodium salt, a cAMP analog, is a potent, competitive cAMP-induced activation of cAMP-dependent PKA I and II (Kis of 12.5 μM and 4.5 μM, respectively) antagonist. Rp-cAMPS sodium salt is resistant to hydrolysis by phosphodiesterases[1][2][3][4][5][6]. A membrane-permeable competitive cAMP antagonist (Rp-cAMPS) that blocks PKA activation by binding to the regulatory subunits without dissociating the kinase holoenzyme also inhibits synaptic plasticity but has no effect on normal synaptic t...

化合物

Adenosine Kinase Inhibitor (hydrate)

Cat.No: T22554

Target: Others

Cat.No: T14944

Target: PI3K, Adenosine Receptor

ABT-702 dihydrochloride

Cat.No: T4668

Target: Adenosine Receptor

ABT-702 hydrochloride

Cat.No: T84880

Synonym: Adenosine Kinase Inhibitor hydrochloride

Target: Others

5-Iodotubercidin

Cat.No: T6745

Synonym: 5-碘代杀结核菌素,5-ITu,NSC 113939

Target: Adenosine Receptor

5'-Amino-5'-deoxyadenosine

Cat.No: T21017

Synonym: 5' Amino 5' deoxyadenosine,5'Amino5'deoxyadenosine,Nsc 238990,NH2dAdo

Target: Apoptosis, Adenosine Receptor

Flavopiridol hydrochloride

Cat.No: T2615

Synonym: Alvocidib Hydrochloride,NSC 649890,MDL 107826A,HL 275,FLAVOPIRIDOL HCL,NSC 649890 HCl

Target: HIV Protease, CDK, Autophagy

Ritodrine hydrochloride

Cat.No: T1433

Synonym: DU21220,盐酸利托君,Ritodrine HCl,NSC 291565

Target: Adrenergic Receptor

Anisodine hydrobromide

Cat.No: T21018

Target: Others

Cat.No: T25145

Synonym: NSC 287022,NSC287022,NSC-287022,Lin-benzoadenosine

Target: Others

ABT 702 hydrochloride

Cat.No: T38346

Target: Others

Cat.No: T70617

Target: Others

AMARA peptide TFA (163560-19-8 free base)

Cat.No: TP1314

Synonym: AMARA peptide TFA

Cat.No: T26475

Target: Others

Adenosine 5'-phosphosulfate (sodium salt)

Cat.No: T35574

Target: Others

AMARA peptide TFA

Cat.No: T75984

Cat.No: T62227

Target: Others

Cat.No: T68267

Target: Others

Cat.No: T74033

Target: Others

Cat.No: T73525

Target: Others

Rp-Adenosine-5'-O-(1-thiodiphosphate) sodium

Cat.No: T83805

Synonym: Rp-ADP-α-S

Target: Others

Sp-Adenosine-5'-O-(1-thiodiphosphate) sodium

Cat.No: T83806

Synonym: Sp-ADP-α-S

Target: Others

Cat.No: T68581

Target: Others

Rp-cAMPS sodium salt

Cat.No: T36679

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T17143	Toyocamycin 丰加霉素,Vengicide	Apoptosis; Others; IRE1; Antibiotic; Antifungal	Apoptosis; Cell Cycle/Checkpoint; Microbiology/Virology; Others
	Toyocamycin (Vengicide) 是放线菌类产生的腺苷类似物，为 X 盒结合蛋白 1 (XBP1) 抑制剂，抑制 IRE1α 诱导的 ATP 依赖性 XBP1 mRNA 的断裂，IC50值为 80 nM。它还诱导凋亡。
T7327	7-Methoxyisoflavone	AMPK	Chromatin/Epigenetic; PI3K/Akt/mTOR signaling
	7-Methoxyisoflavone 是单磷酸腺苷活化蛋白激酶 (AMPK) 的激活剂，是异黄酮衍生物。

天然产物

Cat.No: T17143

Synonym: 丰加霉素,Vengicide

Target: Apoptosis, Others, IRE1, Antibiotic, Antifungal

7-Methoxyisoflavone

Cat.No: T7327

Target: AMPK

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-04473	ADK Protein, Human, Recombinant (His & GST) adenosine kinase,AK	Human	Baculovirus Insect Cells
	Adenosine kinase(ADK) belongs to the family of transferases. Adenosine kinase (ADK) is the key enzyme in adenosine metabolism and catalyzes ATP and adenosine into two products: ADP and AMP. Two isoforms of the enzyme adenosine kinase (ADK), which differ at their N-terminal ends, are found in mammalian cells. It has been shown that the two ADK isoforms differ only in their first exons and the promoter regions; hence they arise via differential splicing of their first exons with the other exons co...
TMPY-04762	CKM Protein, Human, Recombinant (His) creatine kinase, muscle,M-CK,CKMM	Human	E. coli
	CKM, also known as CK-MM, is mainly expressed in skeletal muscle. As the primary CK isoenzyme, it also can be detected in heart muscle. CKM is a subunit of creatine kinase (CK). CK is an enzyme expressed by various tissues and cell types. It catalyses the conversion of creatine and consumes adenosine triphosphate (ATP) to create phosphocreatine and adenosine diphosphate (ADP). In the cells, the cytosolic CK enzymes consist of two subunits, which can be either B (brain type) or M (muscle type).

重组蛋白

ADK Protein, Human, Recombinant (His & GST)

Cat.No: TMPY-04473

Species: Human

Expression System: Baculovirus Insect Cells

CKM Protein, Human, Recombinant (His)

Cat.No: TMPY-04762

Species: Human

Expression System: E. coli

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