购物车
  • 全部删除
  • TargetMol
    您的购物车当前为空

IgG1 Fc Protein, Human, Recombinant (C103S), Biotinylated

产品编号 TMPY-05138

IgG1 Fc Protein, Human, Recombinant (C103S), Biotinylated is expressed in HEK293 mammalian cells. The predicted molecular weight is 26.1 kDa and the accession number is AAC82527.1.

IgG1 Fc Protein, Human, Recombinant (C103S), Biotinylated

IgG1 Fc Protein, Human, Recombinant (C103S), Biotinylated

产品编号 TMPY-05138
IgG1 Fc Protein, Human, Recombinant (C103S), Biotinylated is expressed in HEK293 mammalian cells. The predicted molecular weight is 26.1 kDa and the accession number is AAC82527.1.
规格价格库存数量
20 μg¥ 1,9505日内发货
100 μg¥ 4,6205日内发货
大包装 & 定制
加入购物车
实验操作小课堂
查看更多
TargetMol 的所有产品仅用作科学研究或药证申报,不能被用于人体,我们不向个人提供产品和服务。请您遵守承诺用途,不得违反法律法规规定用于任何其他用途。

产品信息

生物活性
Activity testing is in progress. It is theoretically active, but we cannot guarantee it. If you require protein activity, we recommend choosing the eukaryotic expression version first.
产品描述
IgG1 Fc Protein, Human, Recombinant (C103S), Biotinylated is expressed in HEK293 mammalian cells. The predicted molecular weight is 26.1 kDa and the accession number is AAC82527.1.
种属
Human
表达系统
HEK293 Cells
标签Tag Free
蛋白编号AAC82527.1
别名
Ighg1,IgG1 Fc
蛋白构建
A DNA sequence encoding the IGHG1 (AAC82527.1) (Glu99-Lys330) (one aa mutation,103 Cys/Ser) was expressed. The purified protein was biotinylated in vitro. Predicted N terminal: Glu
蛋白纯度
> 90 % as determined by SDS-PAGE.
分子量26.1 kDa (predicted)
内毒素< 1.0 EU/μg of the protein as determined by the LAL method.
缓冲液Lyophilized from a solution filtered through a 0.22 μm filter, containing Sterile PBS. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
复溶方法
A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储
It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
运输方式In general, Lyophilized powders are shipping with blue ice.
研究背景
As a monomeric immunoglobulin that is predominately involved in the secondary antibody response and the only isotype that can pass through the human placenta, Immunoglobulin G (IgG) is synthesized and secreted by plasma B cells, and constitutes 75% of serum immunoglobulins in humans. IgG antibodies protect the body against the pathogens by agglutination and immobilization, complement activation, toxin neutralization, as well as antibody-dependent cell-mediated cytotoxicity (ADCC). IgG tetramer contains two heavy chains (5 kDa ) and two light chains (25 kDa) linked by disulfide bonds, that is the two identical halves form the Y-like shape. IgG is digested by pepsin proteolysis into Fab fragment (antigen-binding fragment) and Fc fragment ("crystallizable" fragment). IgG1 is most abundant in serum among the four IgG subclasses (IgG1, 2, 3 and 4) and binds to Fc receptors (FcγR ) on phagocytic cells with high affinity. Fc fragment is demonstrated to mediate phagocytosis, trigger inflammation, and target Ig to particular tissues. Protein G or Protein A on the surface of certain Staphylococcal and Streptococcal strains specifically binds with the Fc region of IgGs, and has numerous applications in biotechnology as a reagent for affinity purification. Recombinant IgG Fc Region is suggested to represent a potential anti-inflammatory drug for treatment of human autoimmune diseases.

计算器

  • 复溶 计算器
  • 重组蛋白稀释 计算器
  • 比活力 计算器

技术支持

请阅读 重组蛋白用户指南 了解更多具体信息.