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神经营养因子家族 (Neurotrophins)

神经营养因子 (Neurotrophins) 是一类能诱导神经元存活、发育和功能的蛋白质。它们属于一类生长因子,是分泌的蛋白质,可以向特定细胞发出生存、分化或生长的信号。促进神经元存活的神经营养因子等生长因子被称为神经营养因子。神经营养因子由靶组织分泌,并通过阻止相关神经元启动程序性细胞死亡而起作用,从而使神经元存活。神经营养素还能诱导祖细胞分化,形成神经元。尽管哺乳动物大脑中的绝大多数神经元都是在出生前形成的,但成年大脑的某些部分(例如海马体)仍保留着从神经干细胞中生长新神经元的能力,这一过程被称为神经发生。神经营养素是一种有助于刺激和控制神经发生的化学物质。

GDF-15 Protein, Human, Recombinant (hFc)
TMPY-01073
GDF-15 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 40.6 kDa and the accession number is Q99988.
  • ¥ 1950
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TNF alpha Protein, Mouse, Recombinant
TMPY-01294
TNF alpha Protein, Mouse, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 17.39 kDa and the accession number is P06804.
  • ¥ 1350
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Latent TGF beta 1 Protein, Human, Recombinant (His)
TMPY-01133
Latent TGF beta 1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 42.4 kDa and the accession number is A0A499FJK2.
  • ¥ 1980
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TNF alpha Protein, Human, Recombinant
TMPY-00936
TNF alpha Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 17.5 kDa and the accession number is P01375.
  • ¥ 560
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TGF beta 1 Protein, Human/Rhesus/Cynomolgus/Canine, Recombinant
TMPY-02638
TGF beta 1 Protein, Human Rhesus Cynomolgus Canine, Recombinant is expressed in CHO mammalian cells. The predicted molecular weight is 12.8 kDa and the accession number is A0A499FJK2.
  • ¥ 1950
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TGF beta 1 Protein, Rat/Mouse, Recombinant
TMPY-00608
TGF beta 1 Protein, Rat Mouse, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 12.8 kDa.
  • ¥ 560
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GDF-15 Protein, Human, Recombinant (His)
TMPY-04727
GDF-15 Protein, Human, Recombinant (His) is expressed in yeast with His tag. The predicted molecular weight is 13.7 kDa and the accession number is Q99988.
  • ¥ 3430
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BDNF Protein, Human/Murine/Rat, Recombinant
TMPJ-00135
Brain-Derived Neurotrophic Factor (BDNF) is a member of the neurotrophin family. Along with other structurally related neurotrophic factors NGF, NT-3 and NT-4, BDNF binds with high affinity to the TrkB kinase receptor. It also binds with the LNGFR (for low-affinity nerve growth factor receptor, also known as p75). BDNF promotes the survival, growth and differentiation of neurons. It serves as a major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. BDNF expression is altered in neurodegenerative disorders such as Parkinson's and Alzheimer's disease.
  • ¥ 1170
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TGF beta 2 Protein, Human, Recombinant
TMPJ-00258
Transforming growth factor beta-2 (TGF-β2) is a secreted protein which belongs to the TGF-beta family. It is known as a cytokine that performs many cellular functions and has a vital role during embryonic development. The precursor is cleaved into mature TGF-beta-2 and LAP, which remains non-covalently linked to mature TGF-beta-2 rendering it inactive. It is an extracellular glycosylated protein. It is known to suppress the effects of interleukin dependent T-cell tumors. Defects in TGFB2 may be a cause of non-syndromic aortic disease (NSAD).
  • ¥ 1170
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GDF-15 Protein, Mouse, Recombinant (His)
TMPK-01246
Growth and differentiation factor 15 (GDF15) is an inflammation-associated hormone with poorly defined biology. Here, we investigated the role of GDF15 in bacterial and viral infections. Inflammation induced GDF15, and that GDF15 was necessary for surviving both bacterial and viral infections, as well as sepsis. The protective effects of GDF15 were largely independent of pathogen control or the magnitude of inflammatory response, suggesting a role in disease tolerance. GDF-15 Protein, Mouse, Recombinant (His) is expressed in E. coli expression system with N-His tag. The predicted molecular weight is 13.78 kDa and the accession number is Q9Z0J7.
  • ¥ 3100
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GDF-15 Protein, Rat, Recombinant (His)
TMPK-01243
Growth Differentiation Factor 15 (GDF15), also known as NSAID activated gene-1 (NAG-1), is associated with a large number of biological processes and diseases, including cancer and obesity. GDF15 is synthesized as pro-GDF15, is dimerized, and is cleaved and secreted into the circulation as a mature dimer GDF15. GDF-15 Protein, Rat, Recombinant (His) is expressed in E. coli expression system with N-His tag. The predicted molecular weight is 13.68 kDa and the accession number is Q9Z0J6.
  • ¥ 4440
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TGF beta 3 Protein, Human/Mouse/Rat, Recombinant
TMPJ-00254
Transforming growth factor beta 3(TGFB3) is a member of a TGF -β superfamily which is defined by theirstructural and functional similarities. TGFB3 is secreted as a complex with LAP. This latent form of TGFB3becomes active upon cleavage by plasmin, matrix metalloproteases, thrombospondin -1, and a subset ofintegrins. It binds with high affinity to TGF- β RII, a type II serine threonine kinase receptor. TGFB3 is involved incell differentiation, embryogenesis and development.It is believed to regulate molecules involved in cellularadhesion and extracellular matrix (ECM) formation during the process of palate development. Without TGF-β3,mammals develop a deformity known as a cleft palate.
  • ¥ 1170
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GDNF Protein, Human, Recombinant (HEK293)
TMPY-02792
GDNF Protein, Human, Recombinant (HEK293) is expressed in HEK293 mammalian cells. The predicted molecular weight is 15.1 kDa and the accession number is P39905-2.
  • ¥ 1050
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GDNF Protein, Human, Recombinant
TMPY-06970
GDNF Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 15.2 kDa and the accession number is P39905-1.
  • ¥ 1950
5日内发货
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GDF-15 Protein, Mouse, Recombinant (hFc)
TMPK-01244
Growth and differentiation factor 15 (GDF15) is an inflammation-associated hormone with poorly defined biology. Here, we investigated the role of GDF15 in bacterial and viral infections. Inflammation induced GDF15, and that GDF15 was necessary for surviving both bacterial and viral infections, as well as sepsis. The protective effects of GDF15 were largely independent of pathogen control or the magnitude of inflammatory response, suggesting a role in disease tolerance. GDF-15 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with N-hFc tag. The predicted molecular weight is 37.9 kDa and the accession number is Q9Z0J7.
  • ¥ 3100
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Neurotrophin 3 Protein, Human, Recombinant
TMPY-04069
NTF3 (Neurotrophin 3) is a Protein Coding gene. The protein encoded by this gene is a member of the neurotrophin family, that controls the survival and differentiation of mammalian neurons. This protein is closely related to both nerve growth factor and brain-derived neurotrophic factor. NTF3 is a key mediator of neuronal development during the early neurogenic period. NTF3 is a novel target gene of POU3F2 and that the POU3F2 NTF3 pathway plays a role in the process of neuronal differentiation. NTF3 is capable of activating TrkB to induce anoikis resistance, and show that NTF3 is also a direct target of miR-200c. NTF3 is broadly expressed in the ovary, spleen, and other tissues. Diseases associated with NTF3 include Hypochondriasis and Demyelinating Disease.
  • ¥ 1750
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NGF Protein, Mouse, Recombinant
TMPY-01402
NGF Protein, Mouse, Recombinant is expressed in CHO mammalian cells. The predicted molecular weight is 13.5 kDa and the accession number is P01139.
  • ¥ 1050
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NGF Protein, Mouse, Recombinant (E. colli)
TMPJ-01469
NGF is the first member discovered in the Neurotrophin family, which includes brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3), and neurotrophin-4 (NT-4). These proteins belong to the cysteine-knot family of growth factors that assume stable dimeric structures. Mouse beta -NGF is a homodimer of two 120 amino acid polypeptides. It shares approximately 90% homology at the amino acid level with human beta -NGF and 95.8% with rat beta -NGF. NGF signaling has been shown to play an important role in neuroprotection and repair. β-NGF acts as a growth and differentiation factor for B lymphocytes, and enhances B-cell survival. It is a potent neurotrophic factor that signals through its receptor β-NGFR, and plays a crucial role in the development and preservation of the sensory and sympathetic nervous systems.
  • ¥ 380
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GDNF Protein, Rat, Recombinant (His)
TMPY-02911
GDNF Protein, Rat, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 17.1 kDa and the accession number is Q07731-1.
  • ¥ 3430
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NGF Protein, Human, Recombinant (HEK293)
TMPY-06985
NGF Protein, Human, Recombinant (HEK293) is expressed in HEK293 mammalian cells. The predicted molecular weight is 24.8 kDa. and the accession number is P01138.
  • ¥ 1350
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TGF beta 2 Protein, Mouse/Rat, Recombinant
TMPJ-00261
Transforming growth factor beta 2 (TGF-β2) is a member of TGF-beta superfamily that shares a characteristic cysteine knot structure. Mice with TGF-β2 gene deletion show defects in development of cardiac, lung, craniofacial, limb, spinal column, eye, inner ear and urogenital systems. All TGF-β isoforms signal via the same heteromeric receptor complex, consisting of a ligand binding TGF-β receptor type II (TβR-II), and a TGF-β receptor type I (TβR-I). Signal transduction from the receptor to the nucleus is mediated via SMADs. TGF-β expression is found in cartilage, bone, teeth, muscle, heart, blood vessels, haematopoitic cells, lung, kidney, gut, liver, eye, ear, skin, and the nervous system.
  • ¥ 1170
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Latent TGF beta 1 Protein, Rat, Recombinant (His)
TMPY-03945
Latent TGF beta 1 Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 42.7 kDa and the accession number is P17246.
  • ¥ 1890
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LIF Protein, Mouse, Recombinant
TMPY-04278
LIF Protein, Mouse, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 19.9 kDa and the accession number is P09056.
  • ¥ 1050
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TNF alpha Protein, Human, Recombinant (hFc)
TMPY-04146
TNF alpha Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 45.8 kDa and the accession number is P01375.
  • ¥ 2930
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pro-Beta NGF Protein, Human, Recombinant
TMPJ-01468
The precursor form of the nerve growth factor (proNGF) like its mature form is characterized by the cystin knot motif consisting of three cystine bridges, whereas proneurotrophins and mature neurotrophins elicit opposite biological effects. ProNGF functions preferentially via the complex of pan-neurotrophin receptor p75 (p75NTR) and vps10p domain-containing receptor sortilin inducing neuronal apoptosis and contributing to age- and disease-related neurodegeneration.
  • ¥ 810
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Latent TGF beta 1 Protein, Mouse, Recombinant (His)
TMPY-00500
Latent TGF beta 1 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 42.7 kDa and the accession number is P04202.
  • ¥ 4430
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ARMET/MANF Protein, Human, Recombinant (His)
TMPY-01678
ARMET MANF Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 20 kDa and the accession number is P55145.
  • ¥ 2940
5日内发货
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TGF beta 1 Protein, Mouse/Rat, Recombinant
TMPJ-00771
Transforming growth factor beta 1 (TGFβ1) is the prototype of a growing superfamily of peptide growth factors and plays a prominent role in a variety of cellular processes, including cell-cycle progression, cell differentiation, reproductive function, development, motility, adhesion, neuronal growth, bone morphogenesis, wound healing, and immune surveillance. TGF-β1, TGF-β2 and TGF-β3 signal via the same heteromeric receptor complex, consisting of a ligand binding TGF-β receptor type II (TβR-II), and a TGF-β receptor type I (TβR-I). Signal transduction from the receptor to the nucleus is mediated via SMADs. TGF-β expression is found in cartilage, bone, teeth, muscle, heart, blood vessels, haematopoitic cells, lung, kidney, gut, liver, eye, ear, skin, and the nervous system.
  • ¥ 1170
5日内发货
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pro-BDNF Protein, Human, Recombinant
TMPJ-00134
The precursor form of Brain-Derived Neurotrophic Factor (pro-BDNF) interacts preferentially with the pan-neurotrophin receptor p75 (p75NTR) and vps10p domain-containing receptor sortilin and induces neuronal apoptosis, whereas mature BDNF selectively binds with high affinity to the TrkB kinase receptor and promotes the survival, growth and differentiation of neurons. As proneurotrophins and mature neurotrophins elicit opposite biological effects, Pro-BDNF cleavage in the neuronal system is regulated in a specific and cell-context dependent manner. Pro-BDNF plays important role in negative regulation of neurotrophic actions in the brain.
  • ¥ 820
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TNF alpha Protein, Human, Recombinant (aa 77-233, His)
TMPJ-00124
TNF alpha Protein, Human, Recombinant (aa 77-233, His) is expressed in E. coli expression system with C-6xHis tag. The predicted molecular weight is 16 KDa and the accession number is P01375.
  • ¥ 340
5日内发货
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TGF beta 3 Protein, Human, Recombinant (hFc)
TMPY-06247
TGF beta 3 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 41.2 kDa and the accession number is P10600-1.
  • ¥ 6930
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TNF alpha Protein, Rat, Recombinant
TMPY-02202
TNF alpha Protein, Rat, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 17.4 kDa and the accession number is P16599.
  • ¥ 1360
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NGF Protein, Human, Recombinant
TMPY-01010
NGF Protein, Human, Recombinant is expressed in CHO mammalian cells. The predicted molecular weight is 13.2 kDa and the accession number is P01138.
  • ¥ 1550
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Latent TGF beta 2 Protein, Mouse, Recombinant (His)
TMPY-00413
TGF beta 2 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 46.9 kDa and the accession number is P27090.
  • ¥ 1350
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CNTF Protein, Human, Recombinant (His)
TMPY-01864
CNTF Protein, Human, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 24.5 kDa and the accession number is P26441.
  • ¥ 1350
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Cardiotrophin 1 Protein, Human, Recombinant
TMPY-03917
Cardiotrophin 1 Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 21.2 kDa and the accession number is Q16619-1.
  • ¥ 1630
5日内发货
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GMF beta/GMFB Protein, Human, Recombinant
TMPY-03216
GMFB is a nerve growth factor which belongs to the actin-binding proteins ADF family, GMF subfamily. GMFB is involved in nervous system development, angiogenesis and immune function. It is especially crucial for the nervous system. GMFB causes brain cell differentiation, stimulates neural regeneration and inhibits tumor cell proliferation. It contains 1 ADF-H domain and is phosphorylated after phorbol ester stimulation. GMFB overexpression in astrocytes results in the increase of BDNF production. GMFB expression is increased by exercise, thus BDNF is important for exercise-induction of BDNF.
  • ¥ 3820
5日内发货
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LIF Protein, Human, Recombinant (hFc)
TMPY-03555
LIF Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 46.7 kDa and the accession number is P15018.
  • ¥ 4920
5日内发货
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TGF beta 2 Protein, Mouse, Recombinant (His), Biotinylated
TMPY-05314
TGF beta 2 Protein, Mouse, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 46.9 kDa and the accession number is P27090.
  • ¥ 2440
5日内发货
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TNF alpha Protein, Human, Recombinant, Biotinylated
TMPY-05237
TNF alpha Protein, Human, Recombinant, Biotinylated is expressed in E. coli expression system. The predicted molecular weight is 17.5 kDa and the accession number is P01375.
  • ¥ 1950
5日内发货
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TNF alpha Protein, Human, Recombinant (His & Avi), Biotinylated
TMPK-00121
TNF alpha Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 20.3 kDa and the accession number is P01375.
  • ¥ 5180
5日内发货
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TNF alpha Protein, Human, Recombinant (His & Avi)
TMPK-00120
TNF alpha Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 20.3 kDa and the accession number is P01375.
  • ¥ 2210
5日内发货
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GDF-15 Protein, Cynomolgus, Recombinant (hFc)
TMPK-00663
Growth and differentiation factor 15 (GDF15) is an inflammation-associated hormone with poorly defined biology. Here, we investigated the role of GDF15 in bacterial and viral infections. Inflammation induced GDF15, and that GDF15 was necessary for surviving both bacterial and viral infections, as well as sepsis. The protective effects of GDF15 were largely independent of pathogen control or the magnitude of inflammatory response, suggesting a role in disease tolerance. GDF-15 Protein, Cynomolgus, Recombinant (hFc) is expressed in HEK293 mammalian cells with N-hFc tag. The predicted molecular weight is 37.9 kDa and the accession number is G7PWZ3.
  • ¥ 3100
5日内发货
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TNF alpha Protein, Cynomolgus, Recombinant (His)
TMPK-00119
TNF alpha Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with N-His tag. The predicted molecular weight is 18.35 kDa and the accession number is P79337.
  • ¥ 3100
5日内发货
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GMF beta/GMFB Protein, Human, Recombinant (His)
TMPJ-00024
Glia maturation factor beta (GMFB) contains a ADF-H domain,which is a member of the actin-binding proteins ADF family, GMF subfamily. It is a nerve growth factor implicated in nervous system development, angiogenesis and immune function. GMFB causes differentiation of brain cells, stimulation of neural regeneration, and inhibition of proliferation of tumor cells. It is phosphorylated after phorbol ester stimulation, and is crucial for the nervous system. GMFB overexpression in astrocytes results in the increase of BDNF production. GMFB expression is increased by exercise, thus BDNF is important for exercise-induction of BDNF.
  • ¥ 380
5日内发货
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TGF beta 2 Protein, Canine, Recombinant (His)
TMPY-00231
TGF beta 2 Protein, Canine, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 47 kDa and the accession number is A0A8C0RRP5.
  • ¥ 3430
5日内发货
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GDF-15 Protein (Primary Amine Labeling), Mouse, Recombinant (hFc), Biotinylated
TMPK-01245
Growth and differentiation factor 15 (GDF15) is an inflammation-associated hormone with poorly defined biology. Here, we investigated the role of GDF15 in bacterial and viral infections. Inflammation induced GDF15, and that GDF15 was necessary for surviving both bacterial and viral infections, as well as sepsis. The protective effects of GDF15 were largely independent of pathogen control or the magnitude of inflammatory response, suggesting a role in disease tolerance. GDF-15 Protein (Primary Amine Labeling), Mouse, Recombinant (hFc), Biotinylated is expressed in HEK293 mammalian cells with N-hFc tag. The predicted molecular weight is 37.9 kDa and the accession number is Q9Z0J7.
  • ¥ 6670
5日内发货
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CDNF Protein, Human, Recombinant (His)
TMPY-00568
CDNF Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 20 kDa and the accession number is Q49AH0-1.
  • ¥ 2940
5日内发货
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