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转化生长因子-β 家族 (Transforming Growth Factor-β family, TGF-βs)

转化生长因子-β (Transforming Growth Factor-β, TGF-β) 是一种多功能细胞因子,属于转化生长因子超家族,包括三种不同的哺乳动物亚型(TGF-β 1~3,HGNC编号TGFB1、TGFB2、TGFB3)和许多其他信号蛋白。TGFB 蛋白由所有白细胞谱系产生。活化的 TGF-β 复合物与其他因子形成与 TGF-β 受体结合的丝氨酸/苏氨酸激酶复合物。TGF-β受体由1型和2型受体亚基组成。TGF-β结合后,2型受体激酶磷酸化并激活1型受体激酶,从而激活信号级联反应。TGF-β在干细胞分化以及T细胞调控和分化中也起着至关重要的作用。由于其在免疫和干细胞调控和分化中的作用,它是癌症、自身免疫性疾病和传染病领域中研究最多的细胞因子。

  • GDF-15 Protein, Human, Recombinant (hFc)
    TMPY-01073
    GDF-15 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 40.6 kDa and the accession number is Q99988.
    • ¥ 1950
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    TargetMol | Inhibitor Hot
  • Latent TGF beta 1 Protein, Human, Recombinant (His)
    TMPY-01133
    Latent TGF beta 1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 42.4 kDa and the accession number is A0A499FJK2.
    • ¥ 1980
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  • TGF beta 1 Protein, Human/Rhesus/Cynomolgus/Canine, Recombinant
    TMPY-02638
    TGF beta 1 Protein, Human Rhesus Cynomolgus Canine, Recombinant is expressed in CHO mammalian cells. The predicted molecular weight is 12.8 kDa and the accession number is A0A499FJK2.
    • ¥ 1950
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  • TGF beta 1 Protein, Rat/Mouse, Recombinant
    TMPY-00608
    TGF beta 1 Protein, Rat Mouse, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 12.8 kDa.
    • ¥ 560
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  • Activin A Protein, Human, Mouse, Rat, Cynomolgus, Rhesus, Recombinant
    TMPJ-01471
    Activin and inhibin are two closely related protein complexes that have almost directly opposite biological effects. Activins, members of the TGF-beta superfamily, are disulfide-linked dimeric proteins originally purified from gonadal fluids as proteins that stimulated pituitary follicle stimulating hormone (FSH) release. Inhibins activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Activins are homodimers or heterodimers of the various beta subunit isoforms, while inhibins are heterodimers of a unique alpha subunit and one of the various beta subunits.
    • ¥ 2060
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  • TGF beta 2 Protein, Human, Recombinant
    TMPJ-00258
    Transforming growth factor beta-2 (TGF-β2) is a secreted protein which belongs to the TGF-beta family. It is known as a cytokine that performs many cellular functions and has a vital role during embryonic development. The precursor is cleaved into mature TGF-beta-2 and LAP, which remains non-covalently linked to mature TGF-beta-2 rendering it inactive. It is an extracellular glycosylated protein. It is known to suppress the effects of interleukin dependent T-cell tumors. Defects in TGFB2 may be a cause of non-syndromic aortic disease (NSAD).
    • ¥ 1170
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  • GDF-15 Protein, Human, Recombinant (His)
    TMPY-04727
    GDF-15 Protein, Human, Recombinant (His) is expressed in yeast with His tag. The predicted molecular weight is 13.7 kDa and the accession number is Q99988.
    • ¥ 3430
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  • GDF-15 Protein, Rat, Recombinant (His)
    TMPK-01243
    Growth Differentiation Factor 15 (GDF15), also known as NSAID activated gene-1 (NAG-1), is associated with a large number of biological processes and diseases, including cancer and obesity. GDF15 is synthesized as pro-GDF15, is dimerized, and is cleaved and secreted into the circulation as a mature dimer GDF15. GDF-15 Protein, Rat, Recombinant (His) is expressed in E. coli expression system with N-His tag. The predicted molecular weight is 13.68 kDa and the accession number is Q9Z0J6.
    • ¥ 4440
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  • GDNF Protein, Human, Recombinant
    TMPY-06970
    GDNF Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 15.2 kDa and the accession number is P39905-1.
    • ¥ 1950
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  • GDNF Protein, Human, Recombinant (HEK293)
    TMPY-02792
    GDNF Protein, Human, Recombinant (HEK293) is expressed in HEK293 mammalian cells. The predicted molecular weight is 15.1 kDa and the accession number is P39905-2.
    • ¥ 1050
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  • TGF beta 3 Protein, Human/Mouse/Rat, Recombinant
    TMPJ-00254
    Transforming growth factor beta 3(TGFB3) is a member of a TGF -β superfamily which is defined by theirstructural and functional similarities. TGFB3 is secreted as a complex with LAP. This latent form of TGFB3becomes active upon cleavage by plasmin, matrix metalloproteases, thrombospondin -1, and a subset ofintegrins. It binds with high affinity to TGF- β RII, a type II serine threonine kinase receptor. TGFB3 is involved incell differentiation, embryogenesis and development.It is believed to regulate molecules involved in cellularadhesion and extracellular matrix (ECM) formation during the process of palate development. Without TGF-β3,mammals develop a deformity known as a cleft palate.
    • ¥ 1170
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  • GDF-15 Protein, Mouse, Recombinant (hFc)
    TMPK-01244
    Growth and differentiation factor 15 (GDF15) is an inflammation-associated hormone with poorly defined biology. Here, we investigated the role of GDF15 in bacterial and viral infections. Inflammation induced GDF15, and that GDF15 was necessary for surviving both bacterial and viral infections, as well as sepsis. The protective effects of GDF15 were largely independent of pathogen control or the magnitude of inflammatory response, suggesting a role in disease tolerance. GDF-15 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with N-hFc tag. The predicted molecular weight is 37.9 kDa and the accession number is Q9Z0J7.
    • ¥ 3100
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  • GDF-15 Protein, Mouse, Recombinant (His)
    TMPK-01246
    Growth and differentiation factor 15 (GDF15) is an inflammation-associated hormone with poorly defined biology. Here, we investigated the role of GDF15 in bacterial and viral infections. Inflammation induced GDF15, and that GDF15 was necessary for surviving both bacterial and viral infections, as well as sepsis. The protective effects of GDF15 were largely independent of pathogen control or the magnitude of inflammatory response, suggesting a role in disease tolerance. GDF-15 Protein, Mouse, Recombinant (His) is expressed in E. coli expression system with N-His tag. The predicted molecular weight is 13.78 kDa and the accession number is Q9Z0J7.
    • ¥ 3100
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  • SMAD5 Protein, Mouse, Recombinant (His & GST)
    TMPY-03292
    SMAD5 Protein, Mouse, Recombinant (His & GST) is expressed in Baculovirus insect cells with His and GST tag. The predicted molecular weight is 79.9 kDa and the accession number is P97454.
    • ¥ 3930
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  • Latent TGF beta 1 Protein, Rat, Recombinant (His)
    TMPY-03945
    Latent TGF beta 1 Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 42.7 kDa and the accession number is P17246.
    • ¥ 1890
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  • TGF beta 2 Protein, Mouse/Rat, Recombinant
    TMPJ-00261
    Transforming growth factor beta 2 (TGF-β2) is a member of TGF-beta superfamily that shares a characteristic cysteine knot structure. Mice with TGF-β2 gene deletion show defects in development of cardiac, lung, craniofacial, limb, spinal column, eye, inner ear and urogenital systems. All TGF-β isoforms signal via the same heteromeric receptor complex, consisting of a ligand binding TGF-β receptor type II (TβR-II), and a TGF-β receptor type I (TβR-I). Signal transduction from the receptor to the nucleus is mediated via SMADs. TGF-β expression is found in cartilage, bone, teeth, muscle, heart, blood vessels, haematopoitic cells, lung, kidney, gut, liver, eye, ear, skin, and the nervous system.
    • ¥ 1170
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  • Irisin Protein, Human/Mouse/Rat, Recombinant (N-His)
    TMPJ-01228
    Irisin Protein, Human Mouse Rat, Recombinant (N-His) is expressed in HEK293 mammalian cells with N-6xHis tag. The predicted molecular weight is 18-28 KDa and the accession number is Q8NAU1.
    • ¥ 820
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  • Latent TGF beta 1 Protein, Mouse, Recombinant (His)
    TMPY-00500
    Latent TGF beta 1 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 42.7 kDa and the accession number is P04202.
    • ¥ 4430
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  • Lefty-A Protein, Human, Recombinant (His)
    TMPJ-00238
    Left-right determination factor 2(LEFTY2) is a secreted protein which belongs to the TGF-beta family. Lefty was first identified in a screen for undifferentiated cell-specific cDNAs from the P19 mouse embryonal carcinoma cells. Its mRNA expression on the left side of the developing embryo earned the name “Lefty”. The human orthologue was initially identified as Ebaf, Endometrial bleeding associated factor. Lefty contains the six cysteine residues that are conserved among TGF-β related proteins and that are necessary to form the cysteineknot structure. Its function in patterning left-right asymmetry of the developing organ systems such as the heart and lung is consistent in all vertebrate species examined. Lefty acts as an antagonist to Nodal signaling, potentially by competing for binding to a common receptor. It may play a role in endometrial bleeding.
    • ¥ 220
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  • TGF beta 1 Protein, Mouse/Rat, Recombinant
    TMPJ-00771
    Transforming growth factor beta 1 (TGFβ1) is the prototype of a growing superfamily of peptide growth factors and plays a prominent role in a variety of cellular processes, including cell-cycle progression, cell differentiation, reproductive function, development, motility, adhesion, neuronal growth, bone morphogenesis, wound healing, and immune surveillance. TGF-β1, TGF-β2 and TGF-β3 signal via the same heteromeric receptor complex, consisting of a ligand binding TGF-β receptor type II (TβR-II), and a TGF-β receptor type I (TβR-I). Signal transduction from the receptor to the nucleus is mediated via SMADs. TGF-β expression is found in cartilage, bone, teeth, muscle, heart, blood vessels, haematopoitic cells, lung, kidney, gut, liver, eye, ear, skin, and the nervous system.
    • ¥ 1170
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  • Irisin Protein, Human/Mouse/Rat, Recombinant (C-His)
    TMPJ-01227
    Irisin Protein, Human Mouse Rat, Recombinant (C-His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 20-28 KDa and the accession number is Q8NAU1.
    • ¥ 820
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  • TGF beta 3 Protein, Human, Recombinant (hFc)
    TMPY-06247
    TGF beta 3 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 41.2 kDa and the accession number is P10600-1.
    • ¥ 6930
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  • Latent TGF beta 2 Protein, Mouse, Recombinant (His)
    TMPY-00413
    TGF beta 2 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 46.9 kDa and the accession number is P27090.
    • ¥ 1350
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  • GDF-11 Protein, Human, Recombinant
    TMPJ-00713
    Growth differentiation factor 11(GDF-11) is a secreted protein, which belongs to the transforming growth factor beta superfamily. GDF-11 controls anterior-posterior patterning by regulating the expression of Hox genes. The secreted signal acts globally to specify positional identity along the anterior posterior axis during development. GDF11 has been shown to suppress neurogenesis through a pathway similar to that of myostatin, including stopping the progenitor cell-cycle during G-phase. The similarities between GDF11 and myostatin imply a likelihood that the same regulatory mechanisms are used to control tissue size during both muscular and neural development.
    • ¥ 1170
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  • SMAD3 Protein, Human, Recombinant (His & Flag)
    TMPJ-00271
    Mothers against decapentaplegic homolog 3(SMAD3) is a cytoplasm protein which belongs to the dwarfin SMAD family. Smad proteins undergo rapid nuclear translocation upon stimulation by transforming growth factor and in so doing transduce the signal into the nucleus. Receptor-regulated SMAD is an intracellular signal transducer and transcriptional modulator activated by TGF-beta and activin type 1 receptor kinases. SMAD3 binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD3 SMAD4 complex, activates transcription. It also can form a SMAD3 SMAD4 JUN FOS complex at the AP-1 SMAD site to regulate TGF-beta-mediated transcription. SMAD3 has an inhibitory effect on wound healing probably by modulating both growth and migration of primary keratinocytes and by altering the TGF-mediated chemotaxis of monocytes. This effect on wound healing appears to be hormone-sensitive.
    • ¥ 700
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  • Latent TGF-beta 1 Protein, Mouse, Recombinant (His & Avi), Biotinylated
    TMPJ-00772
    Latent TGF-beta 1 Protein, Mouse, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with N-8xHis-Avi tag. The predicted molecular weight is 13 and 35-45 KDa and the accession number is P04202.
    • ¥ 2260
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  • GDF-15 Protein, Cynomolgus, Recombinant (hFc)
    TMPK-00663
    Growth and differentiation factor 15 (GDF15) is an inflammation-associated hormone with poorly defined biology. Here, we investigated the role of GDF15 in bacterial and viral infections. Inflammation induced GDF15, and that GDF15 was necessary for surviving both bacterial and viral infections, as well as sepsis. The protective effects of GDF15 were largely independent of pathogen control or the magnitude of inflammatory response, suggesting a role in disease tolerance. GDF-15 Protein, Cynomolgus, Recombinant (hFc) is expressed in HEK293 mammalian cells with N-hFc tag. The predicted molecular weight is 37.9 kDa and the accession number is G7PWZ3.
    • ¥ 3100
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  • GDF-15 Protein, Cynomolgus, Recombinant (His)
    TMPK-00665
    Growth and differentiation factor 15 (GDF15) is an inflammation-associated hormone with poorly defined biology. Here, we investigated the role of GDF15 in bacterial and viral infections. Inflammation induced GDF15, and that GDF15 was necessary for surviving both bacterial and viral infections, as well as sepsis. The protective effects of GDF15 were largely independent of pathogen control or the magnitude of inflammatory response, suggesting a role in disease tolerance. GDF-15 Protein, Cynomolgus, Recombinant (His) is expressed in E. coli expression system with N-His tag. The predicted molecular weight is 14.15 kDa and the accession number is G7PWZ3.
    • ¥ 3100
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  • GDF-15 Protein (Primary Amine Labeling), Mouse, Recombinant (hFc), Biotinylated
    TMPK-01245
    Growth and differentiation factor 15 (GDF15) is an inflammation-associated hormone with poorly defined biology. Here, we investigated the role of GDF15 in bacterial and viral infections. Inflammation induced GDF15, and that GDF15 was necessary for surviving both bacterial and viral infections, as well as sepsis. The protective effects of GDF15 were largely independent of pathogen control or the magnitude of inflammatory response, suggesting a role in disease tolerance. GDF-15 Protein (Primary Amine Labeling), Mouse, Recombinant (hFc), Biotinylated is expressed in HEK293 mammalian cells with N-hFc tag. The predicted molecular weight is 37.9 kDa and the accession number is Q9Z0J7.
    • ¥ 6670
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  • GDF-15 Protein (Primary Amine Labeling), Human, Recombinant (H202D, hFc), Biotinylated
    TMPK-00197
    Growth and differentiation factor 15 (GDF15) is an inflammation-associated hormone with poorly defined biology. Here, we investigated the role of GDF15 in bacterial and viral infections. Inflammation induced GDF15, and that GDF15 was necessary for surviving both bacterial and viral infections, as well as sepsis. The protective effects of GDF15 were largely independent of pathogen control or the magnitude of inflammatory response, suggesting a role in disease tolerance. GDF-15 Protein (Primary Amine Labeling), Human, Recombinant (H202D, hFc), Biotinylated is expressed in HEK293 mammalian cells with N-hFc tag. The predicted molecular weight is 37.88 kDa and the accession number is Q99988.
    • ¥ 5930
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  • Latent TGF beta 3 Protein, Human, Recombinant (His)
    TMPK-00258
    Transforming growth factor-betas (TGF-βs) are multifunctional cytokines that have been implicated in the regulation of a broad range of biological processes, including cell proliferation, cell survival, and cell differentiation. And transforming growth factor beta3 (TGFbeta3) is a key protein involved in scar-free healing observed in embryos. Latent TGF beta 3 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with N-His tag. The predicted molecular weight is 45.9 kDa and the accession number is P10600-1.
    • ¥ 3990
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  • TGF-beta 1 Protein, Chicken, Recombinant (His & SUMO)
    TMPH-00382
    TGF-beta 1 Protein, Chicken, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 29.0 kDa and the accession number is P09531.
    • ¥ 2290
    20日内发货
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  • TGF beta 2 Protein, Canine, Recombinant (His)
    TMPY-00231
    TGF beta 2 Protein, Canine, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 47 kDa and the accession number is A0A8C0RRP5.
    • ¥ 3430
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  • GDNF Protein, Human, Recombinant (His & SUMO)
    TMPH-01381
    Neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake. GDNF Protein, Human, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 31.1 kDa and the accession number is P39905.
    • ¥ 1320
    20日内发货
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  • GDF-8 Protein, Human, Recombinant (His)
    TMPH-01415
    Acts specifically as a negative regulator of skeletal muscle growth. MSTN Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 16.4 kDa and the accession number is O14793.
    • ¥ 1320
    20日内发货
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  • TGF beta 2 Protein, Mouse, Recombinant (His), Biotinylated
    TMPY-05314
    TGF beta 2 Protein, Mouse, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 46.9 kDa and the accession number is P27090.
    • ¥ 2440
    5日内发货
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  • SMAD3 Protein, Human, Recombinant (His)
    TMPH-01700
    SMAD3 Protein, Human, Recombinant (His) is expressed in Baculovirus insect cells with N-10xHis tag. The predicted molecular weight is 50.6 kDa and the accession number is P84022.
    • ¥ 1980
    20日内发货
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  • Latent TGF-beta 2 Protein, Human, Recombinant (His & Avi), Biotinylated
    TMPJ-00260
    Latent TGF-beta 2 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with N-8xHis-Avi tag. The predicted molecular weight is 13 and 39-50 KDa and the accession number is P61812.
    • ¥ 5730
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  • LAP (TGF-beta 1) Protein, Human, Recombinant (His & Avi), Biotinylated
    TMPJ-00250
    Transforming growth factor beta (TGFβ) family members are secreted in inactive complexes with a latency-associated peptide (LAP), a protein derived from the N-terminal region of the TGFβ gene product. Extracellular activation of these complexes is a critical step in regulation of TGFβ function in vivo. The TGFβ1 LAP is a ligand for the integrin αvβ6 and that αvβ6-expressing cells induce spatially restricted activition of TGFβ1. And LAP identifies a novel CD4+ CD25+ regulatory T cell subset with TGFbeta-mediated function and enhanced suppression of experimental autoimmune encephalomyelitis.
    • ¥ 2260
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  • TGF beta 3 Protein, Human, Recombinant (Avi), Biotinylated
    TMPJ-00255
    TGF beta 3 Protein, Human, Recombinant (Avi), Biotinylated is expressed in HEK293 mammalian cells with N-Avi tag. The predicted molecular weight is 10-14 KDa and the accession number is P10600.
    • ¥ 5730
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  • INHBC Protein, Human, Recombinant (C-His)
    TMPJ-01015
    Inhibin beta C chain, also known as activin beta-C chain and INHBC, belongs to the TGF-beta family. INHBC forms a homodimeric or heterodimeric through association with alpha and beta subunits, linked by one or more disulfide bonds. Inhibins are heterodimers of one alpha and one beta subunit. Activins are homo- or heterodimers of beta subunits only. Inhibins activins regulates many physiological processes, such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth and so on.
    • ¥ 1170
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  • GDF-8 Protein, Human/Mouse/Rat, Recombinant
    TMPJ-00663
    Growth differentiation factor 8(Mstn, GDF-8) is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. It is expressed specifically in developing and adult skeletal muscle. It exists as a homodimer, and interacts with WFIKKN2, leading to inhibit its activity. This protein can act specifically as a negative regulator of skeletal muscle growth. It regulates cell growth and differentiation in both embryonic and adult tissues.
    • ¥ 2040
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  • SMAD4 Protein, Human, Recombinant (His)
    TMPJ-01108
    SMAD Family Member 4 (SMAD4) is a cytoplasmic protein that belongs to the Dwarfin SMAD family. SMAD4 contains one MH1 (MAD homology 1) domain and one MH2 (MAD homology 2) domain. It is the component of the heterotrimeric SMAD2 SMAD3-SMAD4 complex that forms in the nucleus and is required for the TGF-mediated signaling. SMAD4 promotes binding of the SMAD2 SMAD4 FAST-1 complex to DNA and provides an activation function required for SMAD1 or SMAD2 to stimulate transcription. SMAD4 may act as a tumor suppressor. It positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator. Mutations or deletions in SMAD4 have been shown to result in pancreatic cancer, juvenile polyposis syndrome, and hereditary hemorrhagic telangiectasia syndrome.
    • ¥ 740
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  • GDF-15 Protein (Primary Amine Labeling), Human, Recombinant (hFc), Biotinylated
    TMPK-00198
    Growth and differentiation factor 15 (GDF15) is an inflammation-associated hormone with poorly defined biology. Here, we investigated the role of GDF15 in bacterial and viral infections. Inflammation induced GDF15, and that GDF15 was necessary for surviving both bacterial and viral infections, as well as sepsis. The protective effects of GDF15 were largely independent of pathogen control or the magnitude of inflammatory response, suggesting a role in disease tolerance. GDF-15 Protein (Primary Amine Labeling), Human, Recombinant (hFc), Biotinylated is expressed in HEK293 mammalian cells with N-hFc tag. The predicted molecular weight is 37.9 kDa and the accession number is Q99988.
    • ¥ 6670
    5日内发货
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  • GDF-15 Protein (Primary Amine Labeling), Cynomolgus, Recombinant (hFc), Biotinylated
    TMPK-00664
    Growth and differentiation factor 15 (GDF15) is an inflammation-associated hormone with poorly defined biology. Here, we investigated the role of GDF15 in bacterial and viral infections. Inflammation induced GDF15, and that GDF15 was necessary for surviving both bacterial and viral infections, as well as sepsis. The protective effects of GDF15 were largely independent of pathogen control or the magnitude of inflammatory response, suggesting a role in disease tolerance. GDF-15 Protein (Primary Amine Labeling), Cynomolgus, Recombinant (hFc), Biotinylated is expressed in HEK293 mammalian cells with N-hFc tag. The predicted molecular weight is 37.9 kDa and the accession number is G7PWZ3.
    • ¥ 6670
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  • Activin A Protein, Mouse, Recombinant (His)
    TMPY-01846
    Activin and inhibin are two closely related protein complexes that have almost directly opposite biological effects. The activin and inhibin protein complexes are both dimeric in structure, and, in each complex, the two monomers are linked to one another by a single disulfide bond. Activin is composed of two β subunits, βA βA (activin A), βB βB (activin B), or βA βB (activin AB). Inhibin is composed of an alpha and one of two β subunits, βA (inhibin A) or βB (inhibin B). Activins are produced in many cell types and organs, such as gonads, pituitary gland, and placenta. In the ovarian follicle, activin increases FSH binding and FSH-induced aromatization. It participates in androgen synthesis enhancing LH action in the ovary and testis. In the male, activin enhances spermatogenesis. Also, Activin plays a role in wound repair and skin morphogenesis. Activin is strongly expressed in wounded skin, and overexpression of activin in the epidermis of transgenic mice improves wound healing and enhances scar formation. Activin also regulates the morphogenesis of branching organs such as the prostate, lung, and kidney. There is also evidence showed that lack of activin during development results in neural developmental defects.
    • ¥ 3430
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  • SMAD3 Protein, Human, Mouse, Rat, Recombinant (His & GST)
    TMPY-03419
    SMAD3 belongs to the SMAD family. Members of this family mediate signal transduction by the TGF-beta activin BMP-2 4 cytokine superfamily from receptor Ser Thr protein kinases at the cell surface to the nucleus. SMAD3 is involved in cell signalling. It modulates signals of activin and TGFβ's. Binding of SMAD3 with SMAD4 enables its transmigration into the nucleus where it forms complexes with other proteins and acts as a transcription factor. SMAD3 is a receptor-regulated SMAD (R-SMAD). In mice, mutation of SMAD3 has been linked to colorectal adenocarcinoma, increased systemic inflammation, and accelerated wound healing. Increased SMAD3 activity has been implicated in the pathogenesis of scleroderma. Smad3 is also a multifaceted regulator in adipose physiology and the pathogenesis of obesity and type 2 diabetes.
    • ¥ 2440
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  • Latent TGF beta 1 Protein, Mouse, Recombinant (His), Biotinylated
    TMPY-05313
    Latent TGF beta 1 Protein, Mouse, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 42.7 kDa and the accession number is P04202.
    • ¥ 3630
    5日内发货
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