Tagitinin A (肿柄菊内酯 A)是一种天然的倍半萜内酯化合物,作为过氧化物酶体增殖物激活受体α γ(PPARα PPARγ)的双重激动剂,在糖尿病研究中发挥抗高血糖和抗高血脂作用。Tagitinin A 能够直接结合PPARγ配体结合域(IC50=55 μM),也能刺激PPARα依赖性SULT2A1基因启动子的转录激活。作为植物毒素时Tagitinin A对小麦胚芽鞘的生长有显著的抑制作用。
Tagitinin F possesses antileukemic activity; it also shows in vitro leishmanicidal activities against Leishmania braziliensis promastigotes and amastigotes.
Tirotundin is a PPARα γ dual agonist, it exerts anti-diabetic effect through PPARγ pathway. It shows anti-inflammatory activity, it inhibits inhibit the activation of NF-kappa B, thereby, the synthesis of inflammatory mediators such as cytokines and chemo