用线粒体靶向的CoQH2类似物Ubiquinol（mitoCoQH2）处理，可以保护DHODH敲除细胞免受GPX4抑制剂（即RSL3和ML162）诱导的线粒体脂质过氧化和铁死亡的影响。[5]

The levels of these homologues are highest in heart with lesser amounts occurring in kidney, liver and other organs. In liver and blood plasma, the UQred homologue amounted to 70-80% of the total UQ (UQox + Ubiquinol = t-UQ). Ubiquinol is less than 30% of t-UQ in other tissues and blood cells. t-UQ is much higher in leukocytes and platelets in blood than in erythrocytes. In erythrocytes, t-UQ is exclusively located in the cell membranes.Ubiquinol is also found in all subcellular components isolated from the liver and kidney, and its ratio is approximately the same as the ratio of ubiquinol/t-UQ in the entire organ. The levels of Ubiquinol per mg protein in subcellular fractions from liver is highest in mitochondria, with lesser amounts present in plasma membranes, lysosomes, Golgi complex, nuclei, microsomes and cytosol. In the mitochondria, the outer membranes are richer in t-UQ than the inner membranes[4].