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神经科学

Melanocortin Receptor

Neuropeptide Y Receptor

Serotonin Transporter

(50)

iGluR

(125)

Glutaminyl Cyclase

Glutaminyl Cyclase (QC) is an enzyme that catalyzes the conversion of N-terminal glutamine (Gln) or glutamic acid (Glu) residues into pyroglutamate (pGlu) through cyclization. This modification enhances the stability and bioactivity of proteins and peptides. QC plays a critical role in the formation of pyroglutamate-modified amyloid-β (pGlu-Aβ), which is implicated in Alzheimer's disease and other neurodegenerative disorders. It is considered a potential therapeutic target for diseases involving pGlu-modified peptides.

PBD-150

T7905790663-33-1

PBD-150 是一种人谷氨酰胺酰基环化酶 Y115E-Y117E 变体的抑制剂，其 Ki=490 nM。

¥ 248

现货

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Glutaminyl Cyclase Inhibitor 1

T114242110449-60-8In house

Glutaminyl Cyclase Inhibitor 1 是一种谷氨酰胺环化酶抑制剂（IC50：0.5 μM），可用于研究神经系统疾病。

¥ 497

现货

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Glutaminyl Cyclase Inhibitor 3

T114222092921-50-9

Glutaminyl Cyclase Inhibitor 3, a designed anti-Alzheimer’s compound, is a potent human Glutaminyl Cyclase (GC) inhibitor (IC50: 4.5 nM). It significantly reduced the brain concentrations of pyroform Aβ and total Aβ and restored cognitive functions.

¥ 14800

10-14周

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SEN177

T610632117405-13-5

SEN177 在亨廷顿病的研究中显示出潜力。它是谷氨酰胺环化酶 (QPCT) 的有效抑制剂，对谷氨酰胺肽环转移酶 (QPCTL) 的 IC50值为 0.013 μM。SEN177 对人谷氨酰胺环化酶 (hQC) 的 Ki 值为 20 nM。SEN177 显著降低了突变 HTT 寡聚化的早期阶段，并降低了具有 Q80 聚集体的神经元的百分比。