|
TMPH-01269
|
SMURF2 Protein, Human, Recombinant (His)
SMAD ubiquitination regulatory factor 2,E3 ubiquiti...
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Human
|
E. coli
|
|
E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Interacts with SMAD7 to trigger SMAD7-mediated transforming growth factor beta/TGF-beta receptor ubiquitin-dependent degradation, thereby downregulating TGF-beta signaling. In addition, interaction with SMAD7 activates autocatalytic degradation, which is prevented by interaction with AIMP1. Also forms a stable com... |
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TMPY-02521
|
HIST3H2A Protein, Human, Recombinant
histone cluster 3, H2a,MGC3165
|
Human
|
E. coli
|
|
Histones are a complex family of highly conserved basic proteins responsible for packaging chromosomal DNA into nucleosomes. There are subtype diversities: H1, H2A, H2B, and H3 or H4. It has become more and more evident that histone modifications are key players in the regulation of chromatin states and dynamics as well as in gene expression. Therefore, histone modifications and the enzymatic machinery that set them are crucial regulators that can control cellular proliferation, differentiation,... |
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TMPJ-01403
|
UBE2D4 Protein, Human, Recombinant (GST)
Ubiquitin-Conjugating Enzyme E2 D4,Ubiquitin-Protein Ligase ...
|
Human
|
E. coli
|
|
Ubiquitin-Conjugating Enzyme E2 D4 (UBE2D4) is a ligase that belongs to the Ubiquitin-Conjugating Enzyme family. UBE2D4 has been proposed to participate in Ubl conjugation pathway. UBE2D4 takes part in post-translational protein modification, protein K6-linked ubiquitination, protein K11-linked ubiquitination, protein K27-linked ubiquitination, protein K29-linked ubiquitination, protein K48-linked ubiquitination, and protein K63-linked ubiquitination. UBE2D4 regulate of protein metabolic process... |
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TMPH-03391
|
TRIM2 Protein, Rat, Recombinant (His)
Trim2,Tripartite motif-containing protein 2,E3 ubiquitin-pro...
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Rat
|
E. coli
|
|
E3 ubiquitin-protein ligase that mediates the ubiquitination of phosphorylated BCL2L11. Also mediates the UBE2D1-dependent ubiquitination of NEFL. Plays a neuroprotective function. May play a role in neuronal rapid ischemic tolerance. TRIM2 Protein, Rat, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 85.5 kDa and the accession number is D3ZQG6. |
|
TMPH-01260
|
AMFR Protein, Human, Recombinant (hFc)
gp78,RNF45,AMF receptor,RING finger protein 45,E3 ubiquitin-...
|
Human
|
HEK293 Cells
|
|
E3 ubiquitin-protein ligase that mediates the polyubiquitination of lysine and cysteine residues on target proteins, such as CD3D, CYP3A4, CFTR, INSIG1, SOAT2/ACAT2 and APOB for proteasomal degradation. Component of a VCP/p97-AMFR/gp78 complex that participates in the final step of endoplasmic reticulum-associated degradation (ERAD). The VCP/p97-AMFR/gp78 complex is involved in the sterol-accelerated ERAD degradation of HMGCR through binding to the HMGCR-INSIG1 complex at the ER membrane. In add... |
|
TMPJ-00571
|
UBE2D3 Protein, Human, Recombinant
Ubiquitin-protein ligase D3,Ubiquitin-conjugating enzyme E2(...
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Human
|
E. coli
|
|
UBE2D3 is an enzyme that belongs to the ubiquitin-conjugating enzyme family. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This enzyme functions in the ubiquitination of the tumor-suppressor protein p53, which is induced by an E3 ubiquitin-protein ligase. |
|
TMPY-02950
|
WWP2 Protein, Human, Recombinant (His & GST)
WW domain containing E3 ubiquitin protein ligase 2,AIP2,WWp2...
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Human
|
Baculovirus Insect Cells
|
|
WWP2 contains 1 C2 domain, 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain and 4 WW domains. It is an E3 ubiquitin-protein ligase that accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. WWP2 can be detected in heart, throughout the brain, placenta, lung, liver, muscle, kidney and pancreas. It is also expressed in spleen and peripheral blood leukocytes. WWP2 polyubiquitinates POU5F1 by 'Lys-6... |
|
TMPH-01273
|
TRIP12 Protein, Human, Recombinant (His & Myc)
Thyroid receptor-interacting protein 12,E3 ubiquitin-protein...
|
Human
|
E. coli
|
|
E3 ubiquitin-protein ligase involved in ubiquitin fusion degradation (UFD) pathway and regulation of DNA repair. Part of the ubiquitin fusion degradation (UFD) pathway, a process that mediates ubiquitination of protein at their N-terminus, regardless of the presence of lysine residues in target proteins. Acts as a key regulator of DNA damage response by acting as a suppressor of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of 'Lys-63'-linked histone H2A and H2AX at DNA damag... |
|
TMPH-02136
|
SPSB1 Protein, Human, Recombinant (His)
SPSB1,SPRY domain-containing SOCS box protein 1
|
Human
|
E. coli
|
|
Substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Negatively regulates nitric oxide (NO) production and limits cellular toxicity in activated macrophages by mediating the ubiquitination and proteasomal degradation of NOS2. Acts as a bridge which links NOS2 with the ECS E3 ubiquitin ligase complex components ELOC and CUL5. |
|
TMPH-02847
|
CNPY2 Protein, Mouse, Recombinant (His & Myc)
MIR-interacting saposin-like protein,Tmem4,Transmembrane pro...
|
Mouse
|
E. coli
|
|
Positive regulator of neurite outgrowth by stabilizing myosin regulatory light chain (MRLC). It prevents MIR-mediated MRLC ubiquitination and its subsequent proteasomal degradation. |
|
TMPY-03505
|
COMMD9 Protein, Human, Recombinant (His)
HSPC166,COMM domain containing 9
|
Human
|
E. coli
|
|
COMMD9 is a COMM domain-containing or COMMD protein. COMMD family is comprised of ten members which are widely conserved throughout evolution and share certain functional properties. They represent a recently discovered set of evolutionarily conserved factors characterized by the presence of a defining carboxy-terminal motif. COMMD protein functions in the control of the transcription factor NFkappaB. NFkappaB plays a critical role in a number of homeostatic processes in multicellular orga... |
|
TMPH-01203
|
DCAF16 Protein, Human, Recombinant (His & Myc)
C4orf30,DCAF16,DDB1- and CUL4-associated factor 16
|
Human
|
E. coli
|
|
Functions as a substrate recognition component for CUL4-DDB1 E3 ubiquitin-protein ligase complex, which mediates ubiquitination and proteasome-dependent degradation of nuclear proteins. DCAF16 Protein, Human, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 31.2 kDa and the accession number is Q9NXF7. |
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TMPH-03074
|
UBC5A Protein, Japonica rice, Recombinant (His & Myc)
E2 ubiquitin-conjugating enzyme 5A,Ubiquitin carrier protein...
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Rice
|
E. coli
|
|
E2 conjugating enzyme that associates with the E3 ubiquitin-protein ligase EL5 to mediates ubiquitination of target proteins. UBC5A Protein, Japonica rice, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 23.6 kDa and the accession number is Q8S920. |
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TMPY-02608
|
UBC9/UBE2I Protein, Human, Recombinant
UBC9,ubiquitin-conjugating enzyme E2I,C358B7.1,P18
|
Human
|
E. coli
|
|
UBE2I is a member of the ubiquitin-conjugating E2 family whose members perform the second step in the ubiquitination reaction. Initially identified as the main process for protein degradation, ubiquitination is believed nowadays to be crucial for a wider range of cellular processes. The outcome of the ubiquitin-conjugation reaction, and thereby the fate of the substrate, is heavily dependent on the number of ubiquitin molecules attached and how these ubiquitin molecules are inter-connected. To d... |
|
TMPH-02651
|
Fbxo3 Protein, Mouse, Recombinant (His & Myc)
Muscle atrophy F-box protein,Atrogin-1,Fbxo32,F-box only pro...
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Mouse
|
E. coli
|
|
Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins during skeletal muscle atrophy. Recognizes TERF1. |
|
TMPY-02607
|
Ube2H Protein, Human, Recombinant
UBC8,UBCH2,E2-20K,UBCH,ubiquitin-conjugating enzyme E2H,GID3
|
Human
|
E. coli
|
|
UBE2H is a member of the ubiquitin-conjugating E2 family whose members perform the second step in the ubiquitination reaction. Initially identified as the main process for protein degradation, ubiquitination is believed nowadays to be crucial for a wider range of cellular processes. The outcome of the ubiquitin-conjugation reaction, and thereby the fate of the substrate, is heavily dependent on the number of ubiquitin molecules attached and how these ubiquitin molecules are inter-connected. To d... |
|
TMPH-01259
|
AMFR Protein, Human, Recombinant (His)
Autocrine motility factor receptor,AMF receptor,gp78,RNF45,R...
|
Human
|
E. coli
|
|
E3 ubiquitin-protein ligase that mediates the polyubiquitination of lysine and cysteine residues on target proteins, such as CD3D, CYP3A4, CFTR, INSIG1, SOAT2/ACAT2 and APOB for proteasomal degradation. Component of a VCP/p97-AMFR/gp78 complex that participates in the final step of endoplasmic reticulum-associated degradation (ERAD). The VCP/p97-AMFR/gp78 complex is involved in the sterol-accelerated ERAD degradation of HMGCR through binding to the HMGCR-INSIG1 complex at the ER membrane. In add... |
|
TMPJ-00999
|
UBE2D1 Protein, Human, Recombinant (GST)
Ubiquitin-conjugating enzyme E2(17)KB 1,UB,UbcH5,UBC5A,Stimu...
|
Human
|
E. coli
|
|
Ubiquitin-conjugating enzyme E2 D1（UBE2D1）belongs to the ubiquitin-conjugating enzyme family. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This enzyme is closely related to a stimulator of iron transport (SFT), and is up-regulated in hereditary hemochromatosis. It also functions in the ubiquitination of the tumor-suppressor protein p53 and the hypoxia-inducible transc... |
|
TMPH-01288
|
Elongin-B Protein, Human, Recombinant (GST)
EloB,Elongin-B,TCEB2,ELOB,SIII p18
|
Human
|
E. coli
|
|
SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex). In embryonic stem cells, the elongin BC complex is recruited by EPOP to Polycomb group (PcG) target genes in order generate genomic region ... |
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TMPH-01267
|
RNF13 Protein, Human, Recombinant (His & Myc)
RING finger protein 8,RNF8,E3 ubiquitin-protein ligase RNF8,...
|
Human
|
E. coli
|
|
E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of hist... |
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TMPH-01650
|
PRAME Protein, Human, Recombinant (E. coli, His)
Opa-interacting protein 4,Preferentially expressed antigen o...
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Human
|
E. coli
|
|
Substrate-recognition component of a Cul2-RING (CRL2) E3 ubiquitin-protein ligase complex, which mediates ubiquitination of target proteins, leading to their degradation. The CRL2(PRAME) complex mediates ubiquitination and degradation of truncated MSRB1/SEPX1 selenoproteins produced by failed UGA/Sec decoding. In the nucleus, the CRL2(PRAME) complex is recruited to epigenetically and transcriptionally active promoter regions bound by nuclear transcription factor Y (NFY) and probably plays a role... |
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TMPH-02233
|
P4HTM Protein, Human, Recombinant (His & SUMO)
Transmembrane prolyl 4-hydroxylase,P4HTM,Hypoxia-inducible f...
|
Human
|
E. coli
|
|
Catalyzes the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates HIF1A at 'Pro-402' and 'Pro-564'. May function as a cellular oxygen sensor and, under normoxic conditions, may target HIF through the hydroxylation for proteasomal degradation via the von Hippel-Lindau ubiquitination complex. |
|
TMPY-02609
|
UBE2M Protein, Human, Recombinant
UBC12,UBC-RS2,ubiquitin-conjugating enzyme E2M,hUbc12
|
Human
|
E. coli
|
|
UBE2M is a member of the ubiquitin-conjugating E2 family whose members perform the second step in the ubiquitination reaction. Initially identified as the main process for protein degradation, ubiquitination is believed nowadays to be crucial for a wider range of cellular processes. The outcome of the ubiquitin-conjugation reaction, and thereby the fate of the substrate, is heavily dependent on the number of ubiquitin molecules attached and how these ubiquitin molecules are inter-connected. To d... |
|
TMPY-02605
|
UBE2F Protein, Human, Recombinant (His)
ubiquitin-conjugating enzyme E2F (putative),NCE2
|
Human
|
E. coli
|
|
UBE2F is a member of the ubiquitin-conjugating E2 family whose members perform the second step in the ubiquitination reaction. Initially identified as the main process for protein degradation, ubiquitination is believed nowadays to be crucial for a wider range of cellular processes. The outcome of the ubiquitin-conjugation reaction, and thereby the fate of the substrate, is heavily dependent on the number of ubiquitin molecules attached and how these ubiquitin molecules are inter-connected. To d... |
|
TMPY-02606
|
UBE2G1 Protein, Human, Recombinant
E217K,UBC7,ubiquitin-conjugating enzyme E2G 1,UBE2G
|
Human
|
E. coli
|
|
UBE2G1 is a member of the ubiquitin-conjugating E2 family whose members perform the second step in the ubiquitination reaction. Initially identified as the main process for protein degradation, ubiquitination is believed nowadays to be crucial for a wider range of cellular processes. The outcome of the ubiquitin-conjugation reaction, and thereby the fate of the substrate, is heavily dependent on the number of ubiquitin molecules attached and how these ubiquitin molecules are inter-connected. To ... |
|
TMPY-02604
|
UBE2D4 Protein, Human, Recombinant (His)
HBUCE1,ubiquitin-conjugating enzyme E2D 4 (putative)
|
Human
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E. coli
|
|
UBE2D4 is a member of the ubiquitin-conjugating E2 family whose members perform the second step in the ubiquitination reaction. Initially identified as the main process for protein degradation, ubiquitination is believed nowadays to be crucial for a wider range of cellular processes. The outcome of the ubiquitin-conjugation reaction, and thereby the fate of the substrate, is heavily dependent on the number of ubiquitin molecules attached and how these ubiquitin molecules are inter-connected. To ... |
|
TMPH-02633
|
TRIM21 Protein, Mouse, Recombinant (His)
Tripartite motif-containing protein 21,E3 ubiquitin-protein ...
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Mouse
|
Baculovirus Insect Cells
|
|
E3 ubiquitin-protein ligase whose activity is dependent on E2 enzymes, UBE2D1, UBE2D2, UBE2E1 and UBE2E2. Forms a ubiquitin ligase complex in cooperation with the E2 UBE2D2 that is used not only for the ubiquitination of USP4 and IKBKB but also for its self-ubiquitination. Component of cullin-RING-based SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes such as SCF(SKP2)-like complexes. A TRIM21-containing SCF(SKP2)-like complex is shown to mediate ubiquitination of CDKN1B ('Thr... |
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TMPH-02208
|
TRAF3 Protein, Human, Recombinant
LMP1-associated protein 1,TNF receptor-associated factor 3,R...
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Human
|
E. coli
|
|
Regulates pathways leading to the activation of NF-kappa-B and MAP kinases, and plays a central role in the regulation of B-cell survival. Part of signaling pathways leading to the production of cytokines and interferon. Required for normal antibody isotype switching from IgM to IgG. Plays a role T-cell dependent immune responses. Plays a role in the regulation of antiviral responses. Is an essential constituent of several E3 ubiquitin-protein ligase complexes. May have E3 ubiquitin-protein liga... |
|
TMPY-02842
|
UBE2L6 Protein, Human, Recombinant (His)
UBCH8,ubiquitin-conjugating enzyme E2L 6,RIG-B
|
Human
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E. coli
|
|
UBCH8, also known as UBE2L6, belongs to the ubiquitin-conjugating enzyme family. The family of ubiquitin-conjugating (E2) enzymes is characterized by the presence of a highly conserved ubiquitin-conjugating (UBC) domain. These domains accommodate the ATP-activated ubiquitin (Ub) or ubiquitin-like (UBL) protein via a covalently linked thioester onto its active-site residue. E2 enzymes act via selective protein-protein interactions with the E1 and E3 enzymes and connect activation to covalent modi... |
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TMPH-01270
|
TRAIP Protein, Human, Recombinant (His)
E3 ubiquitin-protein ligase TRAIP,TRAF-interacting protein,T...
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Human
|
E. coli
|
|
E3 ubiquitin ligase required to protect genome stability in response to replication stress. Acts as a key regulator of interstrand cross-link repair, which takes place when both strands of duplex DNA are covalently tethered together, thereby blocking replication and transcription. Controls the choice between the two pathways of replication-coupled interstrand-cross-link repair by mediating ubiquitination of MCM7 subunit of the CMG helicase complex. Short ubiquitin chains on MCM7 promote recruitm... |
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TMPY-00361
|
Pellino-1 Protein, Human, Recombinant (His & GST)
pellino E3 ubiquitin protein ligase 1,PRISM
|
Human
|
Baculovirus Insect Cells
|
|
PELI is a family of E3 ubiquitin ligases that regulate protein activity through a post-translational modification, ubiquitination. PELI1 may function to control inadvertent activation of RIP3, thus preventing aberrant cell death and maintaining cellular homeostasis. PELI1 might participate in B-cell maturation or oncogenic activation of aggressive B-cell lymphomas, both during and after germinal center stages. |
|
TMPY-02642
|
UBE2W Protein, Human, Recombinant (His)
UBC16,UBC-16,ubiquitin-conjugating enzyme E2W (putative)
|
Human
|
E. coli
|
|
Ubiquitin-conjugating enzymes, also known as UBE2W, E2 enzymes and more rarely as ubiquitin-carrier enzymes, perform the second step of protein ubiquitination. The modification of protein with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. UBE2W is a member of th... |
|
TMPH-02632
|
TRIM21 Protein, Mouse, Recombinant (E. coli, His)
Trim21,52 kDa ribonucleoprotein autoantigen Ro/SS-A,Triparti...
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Mouse
|
E. coli
|
|
E3 ubiquitin-protein ligase whose activity is dependent on E2 enzymes, UBE2D1, UBE2D2, UBE2E1 and UBE2E2. Forms a ubiquitin ligase complex in cooperation with the E2 UBE2D2 that is used not only for the ubiquitination of USP4 and IKBKB but also for its self-ubiquitination. Component of cullin-RING-based SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes such as SCF(SKP2)-like complexes. A TRIM21-containing SCF(SKP2)-like complex is shown to mediate ubiquitination of CDKN1B ('Thr... |
|
TMPH-02131
|
SKP2 Protein, Human, Recombinant (His & SUMO)
S-phase kinase-associated protein 2,SKP2,F-box protein Skp2,...
|
Human
|
E. coli
|
|
Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription. Specifically recognizes phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition. Degradation of CDKN1B/p27kip also requires CKS1. Recognizes target proteins ORC1, CDT1, RBL2, KMT2A/MLL1, CDK9, RAG2, FOXO1, UB... |
|
TMPH-01220
|
DDA1 Protein, Human, Recombinant (His)
Placenta cross-immune reaction antigen 1,DET1- and DDB1-asso...
|
Human
|
E. coli
|
|
Functions as a component of numerous distinct DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. In the DCX complexes, acts as a scaffolding subunit required to stabilize the complex. DDA1 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-10xHis tag. The predicted molecular weight is 17.7 kDa and the accession number is Q9BW61. |
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TMPH-03508
|
IpaH9.8 Protein, Shigella flexneri, Recombinant (His)
E3 ubiquitin-protein ligase ipaH9.8,ipaH9.8,Invasion plasmid...
|
Shigella flexneri
|
P. pastoris (Yeast)
|
|
Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. This protein is an E3 ubiquitin ligase that interferes with host's ubiquitination pathway and modulates the acute inflammatory responses, thus facilitating bacterial colonization within the host cell. IpaH9.8 Protein, Shigella flexneri, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 64.0 kDa and the accession number is D2AJU0. |
|
TMPJ-01249
|
ASB13 Protein, Human, Recombinant (His)
ASB13,Ankyrin repeat and SOCS box protein 13
|
Human
|
E. coli
|
|
Ankyrin repeat and SOCS box protein 13(ASB13) is a member of the ankyrin repeat and SOCS box-containing (ASB) family. ASB13 contain six ankyrin repeats sequence and a SOCS box domain. The SOCS box serves to couple suppressor of cytokine signalling (SOCS) proteins and their binding partners with the elongin B and C complex, possibly targeting them for degradation. ASB13 may be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex... |
|
TMPH-01274
|
ZNRF3 Protein, Human, Recombinant (His & SUMO)
RING-type E3 ubiquitin transferase ZNRF3,E3 ubiquitin-protei...
|
Human
|
E. coli
|
|
E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination and subsequent degradation of Wnt receptor complex components Frizzled and LRP6. Acts on both canonical and non-canonical Wnt signaling pathway. Acts as a tumor suppressor in the intestinal stem cell zone by inhibiting the Wnt signaling pathway, thereby resticting the size of the intestinal stem cell zone. Along with RSPO2 and RNF43, constitutes a master switch that governs ... |
|
TMPY-03394
|
RYBP Protein, Human, Recombinant (His & GST)
DEDAF,RING1 and YY1 binding protein,AAP1,YEAF1
|
Human
|
Baculovirus Insect Cells
|
|
APAP-1, also known as AAP1 and RYBP, is widely expressed. It is highest expressed in lymphoid tissues and placenta. APAP-1 contains 1 RanBP2-type zinc finger. It may bind to DNA. APAP-1 inhibits ubiquitination and subsequent degradation of TP53, and thereby plays a role in regulating transcription of TP53 target genes. It may be implicated in the regulation of the transcription as a repressor of the transcriptional activity of E4TF1. APAP-1 also promotes apoptosis. |
|
TMPJ-01138
|
UBE2S Protein, Human, Recombinant (GST)
UBE2S,Ubiquitin-Conjugating Enzyme E2-24 kDa,E2-EPF,E2EPF,Ub...
|
Human
|
E. coli
|
|
Ubiquitin-Conjugating Enzyme E2 S (UBE2S) is a member of the Ubiquitin-Conjugating Enzyme family. UBE2S interacts with CDC20, FZR1/CDH1 and VHL. UBE2S can form a thiol ester linkage with Ubiquitin in an Ubiquitin Activating Enzyme-Dependent manner, a characteristic property of Ubiquitin Carrier Proteins. UBE2S acts as an essential factor of the Anaphase Promoting Complex/Cyclosome, a cell cycle-regulated Ubiquitin ligase that controls progression through mitosis. UBE2S is also involved in ubiqui... |
|
TMPJ-00985
|
UBE2A Protein, Human, Recombinant (GST, His)
RAD6A,HR6A,Ubiquitin-Protein Ligase A,UBE2A,hHR6A,Ubiquitin ...
|
Human
|
E. coli
|
|
Ubiquitin-Conjugating Enzyme E2 (UBE2A) is a member of the E2 Ubiquitin-Conjugating Enzyme family. The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. UBE2A catalyzes the covalent attachment of ubiquitin to other proteins. UBE2A is re... |
|
TMPJ-01362
|
UBAP1 Protein, Human, Recombinant (His)
Nasopharyngeal Carcinoma-Associated Gene 20 Protein,UBAP1,Ub...
|
Human
|
E. coli
|
|
Ubiquitin-Associated Protein 1 (UBAP1) belongs to the UBA domain family. Members of this family are related to ubiquitin and the ubiquitination pathway. Because of their cytogenetic location, this UBA domain family member is being studied as a putative target for mutation in nasopharyngeal carcinomas. UBAP1 is highly expressed in the heart, brain, placenta, lung, skeletal muscle, liver, and pancreas. UBAP1 consists of two UBA domains and one UMA domain. The ubiquitin associated domain is through... |
|
TMPH-01275
|
ZNRF3 Protein, Human, Recombinant (His)
ZNRF3,RING-type E3 ubiquitin transferase ZNRF3,RING finger p...
|
Human
|
HEK293 Cells
|
|
E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination and subsequent degradation of Wnt receptor complex components Frizzled and LRP6. Acts on both canonical and non-canonical Wnt signaling pathway. Acts as a tumor suppressor in the intestinal stem cell zone by inhibiting the Wnt signaling pathway, thereby resticting the size of the intestinal stem cell zone. Along with RSPO2 and RNF43, constitutes a master switch that governs ... |
|
TMPH-01952
|
SPRY2 Protein, Human, Recombinant (His & Myc)
Protein sprouty homolog 2,SPRY2
|
Human
|
E. coli
|
|
Antagonist of fibroblast growth factor (FGF) pathways via inhibition of FGF-mediated phosphorylation of ERK1/2. Thereby acts as an antagonist of FGF-induced retinal lens fiber differentiation, may inhibit limb bud outgrowth and may negatively modulate respiratory organogenesis. Inhibits TGFB-induced epithelial-to-mesenchymal transition in retinal lens epithelial cells. Inhibits CBL/C-CBL-mediated EGFR ubiquitination. SPRY2 Protein, Human, Recombinant (His & Myc) is expressed in E. coli expressio... |
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TMPJ-01324
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UBA5 Protein, Human, Recombinant (His)
Ubiquitin-like modifier-activating enzyme 5,UBE1DC1,UFM1-act...
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Human
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E. coli
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UBA5 is a member of the ubiquitin-activating E1 family and UBA5 subfamily. Ubiquitin and ubiquitin-like proteins are recognized as covalently conjugated to various cellular substrates by a three-step enzymatic pathway. The ubiquitin-activating enzyme (E1) has a vital role in the first step of ubiquitination pathway to activate ubiquitin or ubiquitin-like proteins. UBA5 activates ubiquitin-fold modifier 1, a ubiquitin-like post-translational modifier protein, via the formation of a high-energy th... |
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TMPH-03282
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TRIM63 Protein, Rat, Recombinant (His & Myc)
Muscle-specific RING finger protein 1,Tripartite motif-conta...
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Rat
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E. coli
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E3 ubiquitin ligase. Mediates the ubiquitination and subsequent proteasomal degradation of CKM, GMEB1 and HIBADH. Regulates the proteasomal degradation of muscle proteins under amino acid starvation, where muscle protein is catabolized to provide other organs with amino acids. Inhibits de novo skeletal muscle protein synthesis under amino acid starvation. Regulates proteasomal degradation of cardiac troponin I/TNNI3 and probably of other sarcomeric-associated proteins. May play a role in striate... |
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TMPY-03440
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Sts1 Protein, Human, Recombinant (His)
STS-1,ubiquitin associated and SH3 domain containing B,p70,S...
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Human
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E. coli
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UBASH3B contains a ubiquitin associated domain at the N-terminus, an SH3 domain, and a C-terminal domain with similarities to the catalytic motif of phosphoglycerate mutase. UBASH3B was found to inhibit endocytosis of epidermal growth factor receptor (EGFR) and platelet-derived growth factor receptor. UBASH3B interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases. It promotes accumulation of activated target receptors, such as T-cell receptors and EGFR, on... |
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TMPH-01271
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TRIM63 Protein, Human, Recombinant (His & Myc)
TRIM63,Striated muscle RING zinc finger protein,RING-type E3...
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Human
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E. coli
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E3 ubiquitin ligase. Mediates the ubiquitination and subsequent proteasomal degradation of CKM, GMEB1 and HIBADH. Regulates the proteasomal degradation of muscle proteins under amino acid starvation, where muscle protein is catabolized to provide other organs with amino acids. Inhibits de novo skeletal muscle protein synthesis under amino acid starvation. Regulates proteasomal degradation of cardiac troponin I/TNNI3 and probably of other sarcomeric-associated proteins. May play a role in striate... |
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TMPY-00151
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Alpha SNAP Protein, Human, Recombinant (His)
N-ethylmaleimide-sensitive factor attachment protein, alpha,...
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Human
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E. coli
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NAPA (NSF Attachment Protein Alpha) is a Protein Coding gene. This gene encodes a member of the soluble NSF attachment protein (SNAP) family. SNAP proteins play a critical role in the docking and fusion of vesicles to target membranes as part of the 20S NSF-SNAP-SNARE complex. NAPA represents an anti-apoptotic protein that promotes resistance to cisplatin in cancer cells by inducing the degradation of the tumor suppressor p53. NAPA overexpression decreased the ubiquitination and degradation of s... |
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TMPH-02126
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SORBS2 Protein, Human, Recombinant (His)
Sorbin and SH3 domain-containing protein 2,Arg-binding prote...
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Human
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E. coli
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Adapter protein that plays a role in the assembling of signaling complexes, being a link between ABL kinases and actin cytoskeleton. Can form complex with ABL1 and CBL, thus promoting ubiquitination and degradation of ABL1. May play a role in the regulation of pancreatic cell adhesion, possibly by acting on WASF1 phosphorylation, enhancing phosphorylation by ABL1, as well as dephosphorylation by PTPN12. Isoform 6 increases water and sodium absorption in the intestine and gall-bladder. SORBS2 Pro... |
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