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Cat. No. | Product Name | ||
---|---|---|---|
L2800 | 5-羟色胺分子库 | 268 compounds | |
268 种生物活性小分子化合物,用于高通量、高内涵筛选; |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T5489 |
Tryptophan, N-indol-3-ylacetyl- (6CI)
N-(3-吲哚乙酰基)-L-色氨酸,N-(3-Indolylacetyl)-L-tryptophan,Indole-3-acetyl-L-tryptophan |
Glucosidase | Metabolism |
Tryptophan, N-indol-3-ylacetyl- (6CI) (Indole-3-acetyl-L-tryptophan) 参与调节生理和病理生理反应过程中生长素活性的调节机制。还可用于合成β-D-半乳糖苷酶和β-D-葡萄糖苷酶抑制剂。 | |||
T7694 |
6-fluoro-DL-Tryptophan
|
5-HT Receptor | GPCR/G Protein; Neuroscience |
6-fluoro-DL-Tryptophan 是血清素 (5-HT) 合成的抑制剂。 | |||
T9343 |
N-Cbz-DL-tryptophan
|
cholecystokinin | GPCR/G Protein |
N-Cbz-DL-tryptophan 是一种胆囊收缩素受体拮抗剂,可消除离体心脏对 CCK-8 的反应。 | |||
T11449L |
Golotimod
Gamma-D-glutamyl-L-tryptophan,SCV 07 |
Antibiotic | Microbiology/Virology |
Golotimod (SCV 07) 是一种具有抗菌活性的二肽,具有免疫调节活性,能显著提高抗结核治疗的疗效,诱导胸腺和脾脏细胞增殖,调节巨噬细胞功能,抑制 STAT3 信号传导。Golotimod 可用于研究复发性生殖器单纯疱疹病毒 2 (HSV-2)感染和口腔黏膜炎。 | |||
T2038 |
RG108
N-Phthalyl-L-tryptophan |
DNA Methyltransferase | Chromatin/Epigenetic |
RG108 (N-Phthalyl-L-tryptophan) 是一种非核苷的 DNA 甲基转移酶 (DNMTs) 抑制剂,IC50为115 nM。它阻断 DNA 甲基转移酶的活性位点,可引起抑癌基因的去甲基化和再激活。 | |||
TN7093 |
N-Caffeoyltryptophan
trans-Caffeoyl-L-tryptophan,反式咖啡酰-L-色氨酸 |
Sirtuin | Chromatin/Epigenetic; DNA Damage/DNA Repair |
N-Caffeoyltryptophan (trans-Caffeoyl-L-tryptophan) 是一种潜在的 Sirt 抑制剂,使用咖啡提取物进行筛选。 N-Caffeoyltryptophan 抑制 Sirt2 (IC50; 8.7 μM) 优于 Sirt1 (IC50; 34μM)。 | |||
T20540 |
N-Valyltryptophan
二肽-2,Val-trp,L-Valyl-L-tryptophan |
Others | Others |
N-Valyltryptophan (Val-trp) 是蛋白质分解代谢或蛋白质消化的不完全分解产物。 | |||
T38112 |
DL-Tryptophan octyl ester (hydrochloride)
|
Others | Others |
Tryptophan is an amino acid precursor of serotonin and melatonin. DL-Tryptophan octyl ester is a tryptophan derivative with an octyl ester protected COOH group. This addition creates a stable, cell-permeable molecule capable of generating free tryptophan upon hydrolysis of the ester bond. | |||
T6543 |
Indoximod
NLG-8189,Indoximod (NLG-8189),1-Methyl-D-tryptophan,吲哚莫德 |
Indoleamine 2,3-Dioxygenase (IDO) | Metabolism |
Indoximod (Indoximod (NLG-8189)) 是一种具有口服具有活力的吲哚胺2,3-双加氧酶(IDO) 途径抑制剂。它在调节 mTOR 中充当 Trp 模拟物。它是一种可用于癌症研究的免疫代谢佐剂。 | |||
T33801 |
o-Nitrophenylsulfenyl-lysyl-tryptophan
|
Others | Others |
o-Nitrophenylsulfenyl-lysyl-tryptophan is a bioactive chemical. | |||
T33323 |
Methionyltryptophan
Met-trp,Methionyl-tryptophan,Methionyl tryptophan |
Others | Others |
Methionyl-Tryptophan is a dipeptide composed of methionine and tryptophan. It is an incomplete breakdown product of protein digestion or protein catabolism. | |||
T84937 |
1,1'-Ethylidene-bis-(L-tryptophan)
Peak 97 Contaminant |
Others | Others |
1,1'-Ethylidene-bis-(L-tryptophan) is a potential impurity in L-tryptophan commercial products, promoting EoL-3 eosinophilic leukemia cell proliferation, enhancing eosinophil cationic protein release from human peripheral blood eosinophils, and boosting IL-5 production in human T cells. At 40 µg/kg, it triggers fascia thickening, mast cell infiltration, inflammation, and fibrosis in mouse superficial adipose and panniculus carnosus tissues, serving as an eosinophilia-myalgia syndrome research mo... | |||
T125055 |
N-Malonyl DL-tryptophan
|
Others | Others |
N-Malonyl DL-tryptophan 是一种有用的有机化合物,可用于生命科学领域的相关研究,其产品编号为 T125055。 | |||
T22251 |
680C91
|
Others | Others |
680C91 是一种具有口服活性的色氨酸 2,3-双加氧酶 (TDO) 选择性抑制剂(Ki:51 nM)。它可用于研究肿瘤免疫及阿尔茨海默症。其中TDO 是色氨酸分解代谢的关键酶。 | |||
T21506 |
Telotristat
|
Hydroxylase | Metabolism |
Telotristat 是色氨酸羟化酶 (tryptophan hydroxylase) 抑制剂,在体内的IC50值为0.028 μM。 | |||
T15796 |
LX-1031
|
Hydroxylase; LPA Receptor | GPCR/G Protein; Metabolism |
LX-1031 是一种有效的色氨酸 5-羟化酶抑制剂。 LX-1031 减少外周5-羟色胺的合成。 | |||
T11449 |
Golotimod hydrochloride (229305-39-9 free base)
Golotimod hydrochloride,Gamma-D-glutamyl-L-tryptophan hydrochloride,SCV 07 hydrochloride |
STAT | JAK/STAT signaling; Stem Cells |
Golotimod (SCV 07) hydrochloride 是一种免疫调节肽,具抗菌活性,能显著提升抗结核疾病研究效果。该化合物通过刺激胸腺和脾细胞增殖、改善巨噬细胞功能,展现其生物调节能力。此外,Golotimod hydrochloride 通过抑制STAT3信号传导,有效调节接受放疗或与顺铂联用治疗动物模型中的口腔粘膜炎持续时间和严重程度。还显示出对研究复发性生殖器单纯疱疹病毒 2 型 (HSV-2) 具有潜在应用价值。 | |||
T4410 |
LM10
|
Others | Others |
LM10 是有效的色氨酸 2,3-双加氧酶的抑制剂。色氨酸 2,3-双加氧酶是一种无关的肝酶,它可通过犬尿氨酸途径降解色氨酸。它对研究癌症疾病具有潜在的研究价值。 | |||
T11449L2 |
Golotimod (TFA) (229305-39-9 free base)
SCV 07 (TFA),Gamma-D-glutamyl-L-tryptophan (TFA),Golotimod (TFA) |
STAT | JAK/STAT signaling; Stem Cells |
Golotimod TFA (SCV 07 TFA) 一种免疫调节肽,具有抗菌作用,能够明显增加抗结核研究的效果,刺激胸腺和脾细胞增殖,改善巨噬细胞功能。Golotimod TFA 能够抑制 STAT3 信号传导,调节接受放疗或放疗与顺铂联合用药的动物模型中口腔粘膜炎的持续时间和严重程度。Golotimod TFA 具有潜力进复发性生殖器单纯疱疹病毒 2 型 (HSV-2) 的研究。 | |||
T11897 |
Telotristat ethyl
LX1606 |
Hydroxylase | Metabolism |
Telotristat ethyl (LX1606) 是一种口服具有活力的色氨酸羟化酶抑制剂,可抑制血清素的产生。 | |||
T14119 |
ACT-678689
Compound Example 1.53.4 |
Hydroxylase | Metabolism |
ACT-678689 (Compound Example 1.53.4) 是一种色氨酸羟化酶 (TPH) 抑制剂,IC50=8 nM。 | |||
T10142L |
p-Ethynylphenylalanine hydrochloride
4-Ethynyl-L-phenylalanine HCL,p-Ethynylphenylalanine hydrochloride(278605-15-5 free base) |
Hydroxylase | Metabolism |
p-Ethynylphenylalanine hydrochloride (4-Ethynyl-L-phenylalanine HCL) 是一种高效的、可逆的、选择性的、竞争性的色氨酸羟化酶 (TPH) 抑制剂,其Ki=32.6 μM。 | |||
T3119 |
JNJ-63533054
JNJ 63533054 |
GPR | Endocrinology/Hormones; GPCR/G Protein |
JNJ-63533054 是一种选择性的,具有口服活性的GPR139激动剂,对人GPR139的EC50为 16 nM。它可穿过血脑屏障,对 GPR139 的选择性高于其他 GPCR、离子通道和转运蛋白。 | |||
T19889 |
L-5-BromoTryptophan
L-5-溴色氨酸,5-BrW,5 BrW |
Others | Others |
L-5-BromoTryptophan (5-BrW) 是色氨酸(Trp) 效应物的类似物,可抑制血红蛋白 S 的凝胶化。 | |||
T6044 |
Telotristat Etiprate
LX1606 (Hippurate),LX 1606 Hippurate,特罗司他马尿酸盐 |
Hydroxylase | Metabolism |
Telotristat Etiprate (LX 1606 Hippurate) 是一种色氨酸羟化酶抑制剂,可抑制血清素的产生。 | |||
T41143 |
pCPA methyl ester hydrochloride
4-氯-DL-苯基丙氨酸甲酯盐酸盐,4-Chloro-DL-phenylalanine methyl ester hydrochloride |
5-HT Receptor; Hydroxylase | GPCR/G Protein; Metabolism; Neuroscience |
pCPA methyl ester hydrochloride (4-Chloro-DL-phenylalanine methyl ester hydrochloride) 是色氨酸羟化酶抑制剂和5-HT 合成的抑制剂。 pCPA methyl ester hydrochloride 可穿过血脑屏障并降低 5-HT 中枢可用性。 | |||
T1447 |
Fenclonine
Fenchlonine,PCPA,CP-10188,芬克洛宁,4-Chloro-DL-phenylalanine,DL-4-Chlorophenylalanine |
Hydroxylase | Metabolism |
Fenclonine (CP-10188) 是一种有效的色氨酸羟化酶(Trp)的不可逆抑制剂。其中色氨酸羟化酶是 5-羟色胺生物合成的限速酶。 | |||
TP2359 |
FMOC-DL-7-AZATRYPTOPHAN
|
Others | Others |
FMOC-DL-7-AZATRYPTOPHAN (2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-3-{1H-pyrrolo[2,3-b]pyridin-3-yl}propanoic acid) 是肽。 | |||
T76136 |
Tryptophanase
|
Others | Others |
Tryptophanase 是一种细菌酶,可催化色氨酸降解为吲哚、丙酮酸和氨。 | |||
T81910 |
L-Tryptophanylglycine
|
||
L-Tryptophanylglycine(Trp-gly)作为一种二肽,其对Caco-2细胞摄取Ceronapril具有抑制作用,表现出Ki值为7.19 mM。 | |||
T79189 |
1-Isopropyltryptophan
1-IsoPT |
Indoleamine 2,3-Dioxygenase (IDO) | Metabolism |
1-Isopropyltryptophan (1-IsoPT)为IDO1抑制剂,能够抑制IFN-γ刺激下IDO-1与IDO-2 mRNA的表达水平。 | |||
T29466 |
5-Oxoprolyltryptophan
5-O-Pro-trp |
Others | Others |
5-Oxoprolyltryptophan is a bioactive chemical. | |||
T31798 |
Flavinyltryptophan
|
Others | Others |
Flavinyltryptophan is a flavinyl peptide. | |||
T26297 |
Tryptophanamide
S-Tryptophanamide |
Others | Others |
Tryptophanamide is a chymotrypsin inhibitor. | |||
T125105 |
N-Malonyltryptophan
|
Others | Others |
N-Malonyltryptophan 是一种有用的有机化合物,可用于生命科学领域的相关研究。其产品编号为 T125105,CAS号为 29399-11-9。 | |||
T20542 |
Chloroacetyltryptophan
|
Others | Others |
Chloroacetyltryptophan is a bioactive chemical substance. | |||
TP1319 |
Indolicidin
|
Antibacterial | Microbiology/Virology |
Indolicidin 由 13 个氨基酸组成,其中 5 个是色氨酸残基,羧基末端精氨酸被羧酰胺化。 | |||
T29842 |
Alclofenac
W 7320,烯氯苯乙酸,MY 101,BRN 2116510,W-7320,W7320 |
Others | Others |
Alclofenac (W-7320) 对急性期蛋白反应和L-色氨酸与血浆蛋白结合程度有显著影响,可用于慢性风湿病患者的治疗。 | |||
T10142 |
p-Ethynylphenylalanine
4-Ethynyl-L-phenylalanine |
Others; Hydroxylase | Metabolism; Others |
p-Ethynylphenylalanine (4-Ethynyl-L-phenylalanine) 是一种色氨酸羟化酶(TPH)抑制剂,具有竞争性、有效性、选择性和可逆性,Ki 为32.6 μM。 | |||
T37683 |
3-Hydroxykynurenine
3-hydroxy-DL-Kynurenine,DL-3-Hydroxykynurenine |
Others | Others |
3-Hydroxykynurenine (3-hydroxy-DL-Kynurenine) 是色氨酸的活性代谢物,可抑制酵母和大鼠肝脏醛脱氢酶 97% 和 69%。 | |||
T61202 |
TDO-IN-1
|
Others | Others |
TDO-IN-1 是一种具有口服活性、有效性和选择性的色氨酸 2,3-双加氧酶 (TDO)抑制剂 ,对吲哚胺-2,3-双加氧酶 具有抑制作用。TDO-IN-1 具有抗肿瘤活性, 能够通过逆转肿瘤组织的局部免疫耐受来发挥作用。 | |||
T26258 |
Telotristat besilate
|
Others | Others |
Telotristat besilate is an inhibitor of tryptophan hydroxylase. | |||
T19888 |
6BrW
6-BrW,6 BrW |
Others | Others |
6BrW is an analog of tryptophan effector. | |||
T16780 |
Rodatristat
KAR5417 |
Others | Others |
Rodatristat is an effective tryptophan hydroxylase 1 and TPH2 inhibitor (IC50s: 33 nM and 7 nM, respectively). | |||
T34962 |
Tryptophyl-leucyl-glutamic acid
Trp-leu-glu |
Others | Others |
Tryptophyl-leucyl-glutamic acid is a tryptophan used for fluorescence spectroscopy. | |||
T15426 |
GSK180
|
Hydroxylase | Metabolism |
GSK180 is a selective competitive inhibitor of kynurenine 3-monooxygenase (KMO; IC50: ~6 nM), an enzyme involved in tryptophan metabolism. | |||
T15778 |
LP-533401
|
Hydroxylase | Metabolism |
LP-533401 is an inhibitor of Tryptophan hydroxylase 1. It is used for regulates serotonin production in the gut. | |||
T69135 |
AGN-2979
|
Others | Others |
AGN-2979 is a tryptophan hydroxylase (TPH) activation inhibitor that shows antidepressant properties in rodent models of depression. | |||
T11623 |
IDO/TDO-IN-1
|
Others | Others |
IDO/TDO-IN-1 is an orally active dual indoleamine-2,3-dioxygenase (IDO) and tryptophan 2,3-dioxygenase (TDO) inhibitor (IC50s: 9.7 and 47 nM). | |||
T20799 |
Lobenzarit
Lobenzaritum |
Others | Others |
Lobenzarit, an immunomodulator, is most frequently used to treat arthritis. Its chemical scaffold has been repurposed to tryptophan biosynthesis in Mycobacterium tuberculosis |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
TN2285 |
DL-Tryptophan
(±)-Tryptophan,Tryptophan,DL-色氨酸 |
Serotonin Transporter; Endogenous Metabolite | Metabolism; Neuroscience |
DL-Tryptophan ((±)-Tryptophan) 是内源性代谢产物的一种。 | |||
T0439 |
L-Tryptophan
(S)-Tryptophan,Tryptophan,L-Tryptophane,Tryptophane,L-色氨酸 |
Amino Acids and Derivatives; Endogenous Metabolite | Metabolism |
L-Tryptophan (Tryptophane) 是一种必需氨基酸,是褪黑素、血清素和维生素B3的前体。 | |||
T8789 |
N-Acetyl-L-tryptophan
N-acetyltryptophan,N-乙酰-L-色氨酸 |
Endogenous Metabolite; Neurokinin receptor | GPCR/G Protein; Metabolism; Neuroscience |
N-Acetyl-L-tryptophan (N-acetyltryptophan) 是内源性代谢产物的一种。 | |||
T5235 |
5-Methoxy-DL-tryptophan
|
Others; Endogenous Metabolite | Metabolism; Others |
5-Methoxy-DL-tryptophan 是内源性代谢产物的一种。 | |||
T4806 |
H-D-Trp-OH
D-Tryptophan,D-色氨酸 |
Others; Endogenous Metabolite | Metabolism; Others |
H-D-Trp-OH (D-Tryptophan) 是一种色氨酸的 D 型异构体。它偶尔也会在自然界多肽中被发现,如海洋毒肽。 | |||
T5S0273 |
Hypaphorine
Lenticin,Glyyunnanenine,Tryptophan Betaine,刺桐碱 |
Others | Others |
Hypaphorine (Lenticin) 是一种提取自 Pisolithus tinctorius 中的吲哚类生物碱,对啮齿动物具有有神经学影响降糖活性。 | |||
T4833 |
Ac-DL-Trp-OH
N-乙酰-DL-色氨酸,N-Acetyl-DL-tryptophan |
Others; Endogenous Metabolite | Metabolism; Others |
Ac-DL-Trp-OH (N-Acetyl-DL-tryptophan) 是内源性代谢产物的一种。 | |||
T5718 |
L-(+)-Abrine
L-(+)-红豆碱,L-N-Methyltryptophan,N-α-Methyl-L-tryptophan,L-ABRINE |
Others | Others |
L-(+)-Abrine (L-N-Methyltryptophan) 是一种致命白蛋白,发现于在 Abrus precatorius 种子中,是一种急性毒性生物碱,可用作化学标记物。 | |||
T3S1967 |
(S)-Indoximod
N-ME-Tryptophan,Abrine,相思豆碱,L-Abrine |
Others; Indoleamine 2,3-Dioxygenase (IDO) | Metabolism; Others |
(S)-Indoximod (L-Abrine) 是一种吲哚胺-2,3-双加氧酶 (IDO) 抑制剂,可用于研究癌症。 | |||
T7203 |
Oglufanide
奥谷法奈,L-Glutamyl-L-tryptophan,H-Glu-Trp-OH |
VEGFR; HCV Protease; Endogenous Metabolite | Angiogenesis; Metabolism; Microbiology/Virology; Proteases/Proteasome; Tyrosine Kinase/Adaptors |
Oglufanide (H-Glu-Trp-OH) 是一种从小牛胸腺中分离出来的二肽免疫调节剂,可抑制血管内皮生长因子,可刺激细胞内细菌感染和对丙型肝炎病毒的免疫反应。 | |||
T3003 |
5-hydroxytryptophan
5-羟基色氨酸,NSC-92523 |
Others; Endogenous Metabolite | Metabolism; Others |
5-hydroxytryptophan (NSC-92523) 是色氨酸的代谢物,是5-羟色胺直接的前体,是芳香氨基酸脱羧酶底物。 | |||
T1379 |
L-5-Hydroxytryptophan
5-羟基色氨酸,L-oxitriptan,Oxitriptan,L-5-HTP |
Amino Acids and Derivatives; Endogenous Metabolite | Metabolism |
L-5-Hydroxytryptophan (L-5-HTP) 是一种天然氨基酸和膳食补充剂,可以用作抗抑郁剂、食欲抑制剂和睡眠辅助剂,是神经递质血清素的前体,是利血平(reserpine) 的拮抗剂。它能够用于肌阵挛、纤维肌痛症、偏头痛和小脑共济失调的研究。 | |||
TQ0265 |
Indolelactic acid
|
Endogenous Metabolite | Metabolism |
Indolelactic acid 是 Azotobacter vinelandii 培养中的色氨酸分解代谢物。 | |||
T20585 |
3-Acetylindole
3-乙酰吲哚,Acetyl-3-indole,3-Acetyl-1H-indole,3-Acetylindole |
Others | Others |
3-Acetylindole (3-Acetyl-1H-indole) 可用作取代基和 Sudlow 位点 II 的 L-色氨酸的探针。 | |||
T5984 |
Indole-3-carboxylic acid
3-Indoleformic acid,3-吲哚甲酸 |
Endogenous Metabolite | Metabolism |
Indole-3-carboxylic acid (3-Indoleformic acid) 是尿吲哚色氨酸代谢物,在肝病患者中浓度会升高。 | |||
T7641 |
5-Hydroxytryptophol
5-羟基色醇 |
Endogenous Metabolite | Metabolism |
5-Hydroxytryptophol 是哺乳动物 5-羟色胺的代谢物,它被用作饮酒的生物标志物并可以导致昏睡病。 | |||
T4921 |
Oxoadipic acid
2-氧代己二酸,2-Oxoadipic acid |
Endogenous Metabolite | Metabolism |
Oxoadipic acid (2-Oxoadipic acid) 是必需氨基酸色氨酸和赖氨酸的一种代谢物。 | |||
T4096 |
Quinolinic acid
喹啉酸,pyridine-2,3-dicarboxylic acid,QUIN |
Endogenous Metabolite; NMDAR; iGluR | Membrane transporter/Ion channel; Metabolism; Neuroscience |
Quinolinic acid (QUIN) 是一种内源性 N-甲基-D-天冬氨酸 (NMDA) 受体激动剂,由 L-色氨酸通过犬尿氨酸途径合成,具有调节 NMDA 神经元损伤和功能障碍的潜力。 | |||
T67710 |
3-Indoleacrylic acid
|
Endogenous Metabolite | Metabolism |
3-Indoleacrylic acid 是由链球菌属产生的色氨酸的代谢产物。3-Indoleacrylic acid 对肠上皮屏障功能有有益作用,并减轻免疫细胞的炎症反应。 | |||
T3010 |
Xanthurenic Acid
8-Hydroxykynurenic acid,黄尿酸,4,8-Dihydroxyquinaldic acid,xanthurenate |
Apoptosis; Endogenous Metabolite; GluR | Apoptosis; Metabolism; Neuroscience |
Xanthurenic Acid (8-Hydroxykynurenic acid) 是通过 3-羟基犬尿氨酸转氨而由色氨酸代谢产生的分子,可激活 mGlu2/3 代谢型谷氨酸受体。在下丘脑的感觉传输过程中,它被认为是Group II 代谢型谷氨酸受体的激动剂。 | |||
T4794 |
Glutaric acid
|
Endogenous Metabolite | Metabolism |
Glutaric acid 是一种 C5 二羧酸,是色氨酸和赖氨酸分解代谢途径中的中间体。Glutaric acid 影响周细胞的收缩性和迁移。Glutaric acid 是 I 型戊二酸尿症的生物指标。 | |||
TJO2729 |
L-Alanine
L-2-Aminopropionic acid,alanine,丙氨酸 |
Others; Endogenous Metabolite | Metabolism; Others |
L-Alanine (L-2-Aminopropionic acid) 是一种非必需氨基酸,可参与糖和酸的代谢,为肌肉组织、大脑和中枢神经系统提供能量,并增强免疫力。 | |||
T10938 |
D-Kynurenine
D-尿嘧啶,(R)-2-Amino-4-(2-aminophenyl)-4-oxobutanoic acid,ZINC901103 |
GPR; AhR; Endogenous Metabolite | Endocrinology/Hormones; GPCR/G Protein; Immunology/Inflammation; Metabolism |
D-Kynurenine (ZINC901103) 是 D-色氨酸的代谢物和 GPR109B 的激动剂。 D-Kynurenine 激活 AhR 并促进上皮细胞向间充质的转化。 D-Kynurenine 在 D-氨基酸氧化酶的荧光分析中用作底物。 | |||
T65135 |
Kynurenic acid
Fibrostop 2,Quinurenic acid |
GPR; GluR; NMDAR | Endocrinology/Hormones; GPCR/G Protein; Neuroscience |
Kynurenic acid (Quinurenic acid) 是一种内源性色氨酸活性代谢物,是一种 NMDA, glutamate, α7 nicotinic acetylcholine receptor 三重拮抗剂,也是 GPR35/CXCR8 激动剂,具有神经保护和抗惊厥特性,可用于研究神经分裂和与代谢相关的疾病。 | |||
T4928 |
L-Kynurenine
L-犬尿氨酸,(S)-Kynurenine |
AhR; Aryl Hydrocarbon Receptor; Endogenous Metabolite | Immunology/Inflammation; Metabolism |
L-Kynurenine ((S)-Kynurenine) 是L-色氨酸的代谢物,是芳香烃受体激动剂,可抑制同种异体 T 细胞增殖并增加恶性 U87 神经胶质瘤细胞侵入胶原基质。 | |||
T0647 |
Tryptamine
|
Dehydrogenase; 5-HT Receptor; Endogenous Metabolite; TRP/TRPV Channel | GPCR/G Protein; Membrane transporter/Ion channel; Metabolism; Neuroscience |
Tryptamine 是一种在动物、植物和真菌中发现的单胺生物碱。它含有吲哚环结构,结构类似于色氨酸。在哺乳动物的大脑中发现了微量这种物质,并被认为是一种神经递质或神经调节剂。 | |||
T4707 |
3-Hydroxyanthranilic acid
3-HYDROXY-2-AMINOBENZOIC ACID,3-羟基-2-氨基苯甲酸 |
Others; Antioxidant; Endogenous Metabolite | Metabolism; Others; oxidation-reduction |
3-Hydroxyanthranilic acid是犬尿氨酸途径中的色氨酸代谢物。它已在人类表皮和膀胱组织中发现,并且在多种生物体液中也已检测到,例如尿液和血液。在细胞内,它主要位于细胞质中。 它存在于从酵母到人类的所有真核生物中。 3-Hydroxyanthranilic acid 具有抗氧化活性。 | |||
T4799 |
Indole
|
Others; Endogenous Metabolite | Metabolism; Others |
Indole 它具有双环结构,由一个六元苯环和一个五元含氮吡咯环融合而成。它可以由细菌作为氨基酸色氨酸的降解产物产生。它自然存在于人类粪便中,有强烈的粪便气味。然而,在非常低的浓度下,它有一种花香,是许多花香(如橙花)和香水的成分。 | |||
T4938 |
Potassium 1H-indol-3-yl sulfate
硫酸吲哚钾盐,Indoxyl sulfate potassium salt,Potassium 3-indoxyl sulfate |
AhR; Endogenous Metabolite | Immunology/Inflammation; Metabolism |
Potassium 1H-indol-3-yl sulfate (Potassium 3-indoxyl sulfate) 是人芳烃受体(AhR)的激动剂。芳烃受体(AhR)最近被发现是免疫炎症条件的病理生理调节剂,Potassium 1H-indol-3-yl sulfate 已被证明是AhR的配体。Potassium 1H-indol-3-yl sulfate 也是膳食蛋白质中色氨酸的代谢物。色氨酸被肠道细菌代谢为吲哚,吲哚被吸收到血液中,然后在肝脏中进一步代谢为硫酸吲哚,通常通过尿液排出体外。在肾功能受损的慢性肾病患者中,Potassium 1H-indol-3-yl sulfate 可作为尿毒症毒素在血清中积累,诱导氧化应激并加速疾病进展。250 μM Potassium 1H-indol-3-yl sulfate 可诱导NF-Κb活化,促进大鼠近端小管细胞TGF-β1和Smad3的表达,与促纤维化活性相关。 |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPH-02958 |
Tryptophan Hydroxylase 1 Protein, Mouse, Recombinant (His & SUMO)
Tryptophan 5-monooxygenase 1,Tryptophan 5-... |
Mouse | E. coli |
Oxidizes L-tryptophan to 5-hydroxy-l-tryptophan in the rate-determining step of serotonin biosynthesis. Tryptophan Hydroxylase 1 Protein, Mouse, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 67.3 kDa and the accession number is P17532. | |||
TMPY-01959 |
Tryptophan Hydroxylase 1/TPH-1 Protein, Human, Recombinant (His)
TPRH,tryptophan hydroxylase 1,TRPH |
Human | E. coli |
Tryptophan 5-hydroxylase 1, also known as Tryptophan 5-monooxygenase 1, Tryptophan hydroxylase 1, TPH1, TPH and TPRH, is an enzyme that belongs to the biopterin-dependent aromatic amino acid hydroxylase family. TPH1 contains one ACT domain. Tryptophan hydroxylase catalyzes the biopterin-dependent monooxygenation of tryptophan to 5-hydroxytryptophan (5HT), which is subsequently decarboxylated to form the neurotransmitter serotonin. It is the rate-limiting enzyme in the biosynthesis of serotonin. ... | |||
TMPJ-00819 |
Trp A Protein, E. coli, Recombinant
Tryptophan synthase α chain,trpA,Tryptophan |
E. coli | E. coli |
Trp A Protein, E. coli, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 27 KDa and the accession number is P0A877. | |||
TMPH-02259 |
TPH2 Protein, Human, Recombinant (His)
Tryptophan 5-hydroxylase 2,TPH2,Tryptophan... |
Human | E. coli |
N/A. TPH2 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 60.1 kDa and the accession number is Q8IWU9. | |||
TMPJ-00820 |
Trp B Protein, E. coli, Recombinant (His)
trpB,Tryptophan synthase β chain,Tryptophan |
E. coli | E. coli |
Trp B Protein, E. coli, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 40-50 KDa and the accession number is P0A879. | |||
TMPY-02584 |
14-3-3 beta Protein, Cynomolgus, Recombinant
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase... |
Cynomolgus | E. coli |
14-3-3 beta Protein, Cynomolgus, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 27.8 kDa and the accession number is Q4R572-2. | |||
TMPY-02179 |
14-3-3 epsilon Protein, Mouse, Recombinant (GST)
AU019196,tyrosine 3-monooxygenase/tryptophan 5-mono... |
Mouse | E. coli |
14-3-3 epsilon Protein, Mouse, Recombinant (GST) is expressed in E. coli expression system with GST tag. The predicted molecular weight is 56.1 kDa and the accession number is P62259. | |||
TMPY-02378 |
14‑3‑3 theta/YWHAQ Protein, Human, Recombinant (GST)
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase... |
Human | E. coli |
The recently identified 14-3-3 tau, whose corresponding gene name is YWHAQ, is in a hypoxia-treated human trophoblast cell line. YWHAQ may play a role in epigenetic regulation of placental genes in the onset of Preeclampsia (PE). Moreover, there was a closer relationship between blood pressure and methylation levels of the YWHAQ promoter. | |||
TMPY-02377 |
14-3-3 eta/YWHAH Protein, Human, Recombinant (GST)
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase... |
Human | E. coli |
YWHAH, the gene encoding the 14-3-3eta isoform, is highly expressed in retinal ganglion cells (RGC). YWHAH is a positional and functional candidate gene for both schizophrenia and bipolar disorder (BP). It is located on chromosome 22q12.3, a region that has been implicated by linkage studies in both BP and schizophrenia. | |||
TMPY-01267 |
14-3-3 epsilon Protein, Human, Recombinant (GST)
MDCR,MDS,HEL2,14-3-3E,tyrosine 3-monooxygenase/tryptopha... |
Human | E. coli |
14-3-3 epsilon Protein, Human, Recombinant (GST) is expressed in E. coli expression system with GST tag. The predicted molecular weight is 56 kDa and the accession number is P62258-1. | |||
TMPY-01274 |
14-3-3 epsilon Protein, Human, Recombinant
HEL2,MDCR,tyrosine 3-monooxygenase/tryptophan 5-mon... |
Human | E. coli |
14-3-3 epsilon Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 29.4 kDa and the accession number is P62258-1. | |||
TMPY-01266 |
14-3-3 beta Protein, Human, Recombinant (GST)
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase... |
Human | E. coli |
14-3-3 beta Protein, Human, Recombinant (GST) is expressed in E. coli expression system with GST tag. The predicted molecular weight is 54.9 kDa and the accession number is P31946-1. | |||
TMPY-01273 |
14-3-3 beta Protein, Human, Recombinant
14-3-3 β,YWHAA,tyrosine 3-monooxygenase/tryptophan ... |
Human | E. coli |
14-3-3 beta Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 28 kDa and the accession number is P31946-1. | |||
TMPH-01597 |
KYAT1 Protein, Human, Recombinant (His & SUMO)
Kynurenine aminotransferase 1,KYAT1,Glutamine--phenylpyruvat... |
Human | E. coli |
Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA), an intermediate in the tryptophan catabolic pathway which is also a broad spectrum antagonist of the three ionotropic excitatory amino acid receptors among others. Also metabolizes the cysteine conjugates of certain halogenated alkenes and alkanes to form reactive metabolites. Catalyzes the beta-elimination of S-conjugates and Se-conjugates of L-(seleno)cysteine, resulting in the cl... | |||
TMPY-02803 |
IDO2 Protein, Human, Recombinant (His)
indoleamine 2,3-dioxygenase 2,INDOL1 |
Human | E. coli |
IDO2 belongs to the indoleamine 2,3-dioxygenase family. Indoleamine 2,3-dioxgyenase (IDO), is a cytosolic haem protein which, together with the hepatic enzyme tryptophan 2,3-dioxygenase, catalyzes the conversion of tryptophan and other indole derivatives to kynurenines. In addition to classic IDO (IDO1), a new variant, IDO2, has recently been described. IDO2 is expressed in the liver, small intestine, spleen, placenta, thymus, lung, brain, kidney, and colon. IDO is widely distributed in human ti... | |||
TMPH-00726 |
Ribokinase Protein, E. coli, Recombinant (His)
Ribokinase,rbsK |
E. coli | E. coli |
Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway. | |||
TMPH-02679 |
QPCT Protein, Mouse, Recombinant (His)
Glutaminyl cyclase,Glutaminyl-tRNA cyclotransferase,Qpct,Glu... |
Mouse | P. pastoris (Yeast) |
Responsible for the biosynthesis of pyroglutamyl peptides. Has a bias against acidic and tryptophan residues adjacent to the N-terminal glutaminyl residue and a lack of importance of chain length after the second residue. QPCT Protein, Mouse, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 39.6 kDa and the accession number is Q9CYK2. | |||
TMPH-02680 |
QPCT Protein, Mouse, Recombinant (His & Myc)
Glutaminyl cyclase,Qpct,Glutaminyl-peptide cyclotransferase,... |
Mouse | HEK293 Cells |
Responsible for the biosynthesis of pyroglutamyl peptides. Has a bias against acidic and tryptophan residues adjacent to the N-terminal glutaminyl residue and a lack of importance of chain length after the second residue. QPCT Protein, Mouse, Recombinant (His & Myc) is expressed in HEK293 mammalian cells with N-6xHis-Myc tag. The predicted molecular weight is 41.6 kDa and the accession number is Q9CYK2. | |||
TMPH-01596 |
AADAT Protein, Human, Recombinant (His & SUMO)
2-aminoadipate transaminase,Glycine transaminase AADAT,Alpha... |
Human | E. coli |
Transaminase with broad substrate specificity. Has transaminase activity towards aminoadipate, kynurenine, methionine and glutamate. Shows activity also towards tryptophan, aspartate and hydroxykynurenine. Accepts a variety of oxo-acids as amino-group acceptors, with a preference for 2-oxoglutarate, 2-oxocaproic acid, phenylpyruvate and alpha-oxo-gamma-methiol butyric acid. Can also use glyoxylate as amino-group acceptor (in vitro). | |||
TMPJ-01197 |
CRELD2 Protein, Human, Recombinant (His)
Cysteine-Rich With EGF-Like Domain Protein 2,CRELD2 |
Human | HEK293 Cells |
Cysteine-Rich with EGF-Like Domain Protein 2 (CRELD2) is a secreted protein that is a member of the CRELD family. Human CRELD2 is synthesized as a 353 amino acid precursor protein with a signal peptide, a highly conserved domain rich in glutamic acid and tryptophan (WE) and EGF-like repeats. CRELD2 is ubiquitously expressed in many tissues. CRELD2 may interact with CHRNA4 and regulate transport of α4-β2 neuronal acetylcholine receptor. In addition, CRELD2 could be a novel mediator in regulating ... | |||
TMPJ-00473 |
QPRTase Protein, Human, Recombinant (His)
QPRTase,QAPRTase,Nicotinate-Nucleotide Pyrophosphorylase [Ca... |
Human | E. coli |
Nicotinate-Nucleotide Pyrophosphorylase (QPRT) belongs to the nadC/modD family. QPRT plays an improtant role in catabolism of quinolinate which acts as a potent endogenous exitotoxin to neurons. In addition, QPRT serves as an an intermediate in the Tryptophan-Nicotinamide Adenine Dinucleotide pathway. QPRT participates in some pathways including Cofactor biosynthesis, NAD(+) biosynthesis and the Nicotinate D-Ribonucleotide from Quinolinate. In addition, QPRT is involved in the catabolism of Quin... | |||
TMPJ-01110 |
IRF5 Protein, Human, Recombinant (His)
Interferon Regulatory Factor 5,IRF5,IRF-5 |
Human | E. coli |
Interferon Regulatory Factor 5 (IRF5) is a member of the IRF family. It contains one IRF tryptophan pentad repeat DNA-binding domain. IRF5 shuttles between the nucleus and the cytoplasm. IRF5 can form homodimer when it is phosphorylated. IRF5 functions as a transcription factor involved in the induction of interferons IFNA and INFB and inflammatory cytokines upon virus infection. Genetic variations in IRF5 are associated with susceptibility to systemic lupus erythematosus type 10. In addition, ... | |||
TMPY-03753 |
WARS Protein, Human, Recombinant (His)
tryptophanyl-tRNA synthetase,GAMMA-2,γ-2,IFI53,IFP5... |
Human | Baculovirus Insect Cells |
WARS, also known as TrpRS, is an aminoacyl-tRNA synthetase that belongs to the class-I aminoacyl-tRNA synthetase family. There are two forms of tryptophanyl-tRNA synthetase: a cytoplasmic form, named WARS, and a mitochondrial form, named WARS2. They catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in ... | |||
TMPJ-00813 |
QDPR Protein, Human, Recombinant (His)
Dihydropteridine Reductase,QDPR,DHPR,HDHPR,Quinoid Dihydropt... |
Human | HEK293 Cells |
Dihydropteridine reductase, also known as HDHPR and Quinoid dihydropteridine reductase, QDPR and DHPR, belongs to the short-chain dehydrogenases/reductases (SDR) family. QDPR exists as a homodimer. QDPR is part of the pathway that recycles a substance called tetrahydrobiopterin, also known as BH4 and tryptophan hydroxylases. The regeneration of this substance is critical for the proper processing of several other amino acids in the body. Tetrahydrobiopterin also helps produce certain chemicals i... | |||
TMPY-06815 |
SYAP1 Protein, Human, Recombinant (His)
PRO3113,synapse associated protein 1 |
Human | Baculovirus Insect Cells |
Synapse-associated protein 1 (SYAP1), also known as PRO3113 and BSTA, belongs to the synapse-associated BSD domain family, featuring three α-helices and two conserved tryptophan and phenylalanine residues located at the C-terminus. Expressed near neuronal Golgi and synaptic regions of cerebellar Purkinje cells, SYAP1 has been linked to intact sensorimotor control and general vesicular trafficking in neurons. SYAP1-deficient mice display impaired locomotor activity. In cultured adipocytes, SYAP1 ... | |||
TMPJ-00602 |
CPA2 Protein, Human, Recombinant (His)
CPA2,Carboxypeptidase A2 |
Human | HEK293 Cells |
Carboxypeptidase A2 (CPA) is a secreted pancreatic procarboxy-peptidase that cleaves the C-terminal amide or ester bond of peptides that have a free C-terminal carboxyl group. The hydrolytic action of CPA2 was identified with a preference towards long substrates with aromatic amino acids in their C-terminal end, particularly tryptophan. CPA2 comprises a signal peptide, a pro region and a mature chain, and can be activated after cleavage of the pro peptide. Three different forms of human pancreat... | |||
TMPH-01248 |
ADAR Protein, Human, Recombinant (His & SUMO)
ADAR1,IFI-4,136 kDa double-stranded RNA-binding protein,Inte... |
Human | E. coli |
Catalyzes the hydrolytic deamination of adenosine to inosine in double-stranded RNA (dsRNA) referred to as A-to-I RNA editing. This may affect gene expression and function in a number of ways that include mRNA translation by changing codons and hence the amino acid sequence of proteins; pre-mRNA splicing by altering splice site recognition sequences; RNA stability by changing sequences involved in nuclease recognition; genetic stability in the case of RNA virus genomes by changing sequences duri... |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
TMID-0151 |
5-Hydroxy-L-tryptophan-4,6,7-d3
|
||
5-Hydroxy-L-tryptophan-4,6,7-d3 是 5-Hydroxy-L-tryptophan 的氘代化合物。5-Hydroxy-L-tryptophan 的 CAS 号为 314062-44-7。 | |||
T70313 |
Indoxyl Sulfate-d5 potassium salt
|
||
Indoxyl sulfate-d5 is intended for use as an internal standard for the quantification of indoxyl sulfate by GC- or LC-MS. Indoxyl sulfate is a uremic toxin and a metabolite of tryptophan. It is formed via sulfation of indole, an intermediate generated from tryptophan by intestinal bacteria, by the sulfotransferase (SULT) isoform 1A1 variant 2 (SULT1A1*2) in the liver. Indoxyl sulfate activates the aryl hydrocarbon receptor (AhR) in HepG2 40/6 hepatoma cells (EC50 = 12.1 nM in a reporter assay). ... | |||
TMID-0171 |
Kynurenic Acid-d5
|
||
Kynurenic Acid-d5 是 Kynurenic Acid 的氘代化合物。Kynurenic Acid 的 CAS 号为 492-27-3。Kynurenic acid 是一种内源性色氨酸代谢物,是针对靶点NMDA、谷氨酸、α7烟碱型乙酰胆碱受体的广谱拮抗剂。它也是GPR35/CXCR8激动剂。 | |||
TMIH-0046 |
3-Indoleacrylic acid-d4
|
||
3-Indoleacrylic acid-d4 是 3-Indoleacrylic acid 的氘代化合物。3-Indoleacrylic acid 的 CAS 号为 1204-06-4。3-Indoleacrylic acid是由链球菌属产生的色氨酸的代谢产物。3-Indoleacrylic acid对肠上皮屏障功能有有益作用,并减轻免疫细胞的炎症反应。 | |||
TMIJ-0518 |
L-Kynurenine-d4-1
|
||
L-Kynurenine-d4-1 是 L-Kynurenine 的氘代化合物。L-Kynurenine 的 CAS 号为 2922-83-0。L-Kynurenine是L-色氨酸的代谢物,是芳香烃受体激动剂,可抑制同种异体 T 细胞增殖并增加恶性 U87 神经胶质瘤细胞侵入胶原基质。 | |||
TMID-0071 |
L-Kynurenine-d4
|
||
L-Kynurenine-d4 是 L-Kynurenine 的氘代化合物。L-Kynurenine 的 CAS 号为 2922-83-0。L-Kynurenine是L-色氨酸的代谢物,是芳香烃受体激动剂,可抑制同种异体 T 细胞增殖并增加恶性 U87 神经胶质瘤细胞侵入胶原基质。 |