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Search Results for " superoxide "

Targets Recommended: Others

97

抑制剂 & 化合物

45

天然产物

28

重组蛋白

4

同位素标记化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T78346	Superoxide dismutase SOD	Others	Others
	超氧化物歧化酶(SOD)是能清除超氧阴离子的抗氧化酶，它将自由基转化为氧气和过氧化氢，防止过氧亚硝酸盐的形成和进一步损伤。该酶在抗炎、抗肿瘤、辐射防护及抗衰老领域有着广泛应用和研究。
T40612	Manganese(salen) chloride EUK-8	Others	Others
	Manganese(salen) chloride (EUK-8) 是超氧化物歧化酶和过氧化氢酶的一种模拟物，具有氧自由基清除性能。它可减轻内毒素血症猪的急性肺损伤。
T8531	m-3M3FBS 2,4,6-三甲基-N-[3-(三氟甲基)苯基]苯磺酰胺	Apoptosis; Phospholipase	Apoptosis; Metabolism
	m-3M3FBS 是一种有效的磷脂酶C 激活剂，刺激人中性粒细胞产生超氧物，上调细胞内钙离子浓度，刺激多种细胞产生磷酸肌醇。它诱导单核细胞白血病细胞凋亡。
T2686	Esomeprazole Magnesium (S)-Omeprazole magnesium,NEXIUM,埃索美拉唑镁,(-)-Omeprazole magnesium	ATPase; Proton pump	Membrane transporter/Ion channel
	Esomeprazole Magnesium (NEXIUM) 是一种口服有效的 H+, K+-ATPase 抑制剂，在上消化道疾病和胃食管反流疾病中具有研究价值。Esomeprazole magnesium 是一种外泌体抑制剂，通过抑制 V-H+-ATPases 来阻断外泌体的释放。
T19930	Nitrosoglutathione S-Nitrosoglutathione,S-亚硝基谷胱甘肽,SNOG,Glutathione thionitrite,GSNO	RAAS; NO Synthase	Endocrinology/Hormones; Immunology/Inflammation
	Nitrosoglutathione (GSNO) 是一种外源性的 NO 供体，是大鼠酒精脱氢酶III 类同工酶的底物，能够减少脑血管紧张素II 依赖性及非依赖型的 AT1 受体反应。
T8386	Esomeprazole Magnesium trihydrate 埃索美拉唑镁三水合物,埃索美拉唑镁(三水),(S)-Omeprazole magnesium trihydrate	Proton pump	Membrane transporter/Ion channel
	Esomeprazole Magnesium trihydrate ((S)-Omeprazole magnesium trihydrate) 是一种口服有效的H+, K+-ATPase 抑制剂，在上消化道疾病和胃食管反流疾病的研究中具有价值。它是一种外泌体抑制剂，通过抑制 V-H+-ATPases 来阻断外泌体的释放。
T6495	EUK-134 EUK 134,乙基双亚氨基甲基愈创木酚锰氯化物	Beta Amyloid	Neuroscience
	EUK-134 是合成的超氧化物歧化酶和过氧化氢酶模拟物，可保护大鼠肾脏免受缺血再灌注引起的损伤。它作用于 H9C2 细胞，降低NF-κB 表达、MDA 水平和蛋白质羰基化。它是具有过氧化氢酶活性的超氧化物歧化酶 (SOD) 模拟物 (SODm)。它是保护有丝分裂的抗氧化剂。
T19428	Mito-TEMPO	Reactive Oxygen Species; Mitochondrial Metabolism	Immunology/Inflammation; Metabolism; NF-κB
	Mito-TEMPO 是一种线粒体靶向超氧化物歧化酶的模拟物。Mito-TEMPO 可以清除超氧化物和烷基自由基，防止线粒体的氧化、坏死和凋亡。
T2021	Dihydroethidium 二氢乙锭,PD-MY 003,Hydroethidine	Others	Others
	Dihydroethidium (PD-MY 003) 是一种过氧化物指示剂，在细胞质中具有蓝色荧光，被氧化后荧光消失，λex=518 nm，λem=616 nm。
T6699	Tempol TMPN,Tanol,4-Hydroxy-TEMPO,阻聚剂701	Reactive Oxygen Species; ROS; Autophagy	Autophagy; Immunology/Inflammation; Metabolism; NF-κB
	Tempol (Tanol) 是一种超氧化物歧化酶类似物，可有效中和活性氧，具有抗炎、神经保护和镇痛作用。
T40795	BNTA	Reactive Oxygen Species	Immunology/Inflammation; Metabolism; NF-κB
	BNTA 是一种有效的细胞外基质 (ECM) 调节剂。在大鼠关节炎模型中，BNTA 通过诱导超氧化物歧化酶 3 (SOD3) 促进软骨细胞上软骨结构分子的合成和超氧阴离子消除调节软骨生成从而调节关节炎。
T5426	DMNQ	Reactive Oxygen Species; ROS	Immunology/Inflammation; Metabolism; NF-κB
	DMNQ 是氧化还原循环剂，以浓度依赖性方式在细胞内产生超氧化物和过氧化氢，能够诱导ROS 增加。
T19668	Tiomolibdate diammonium Ammonium molybdenum sulfide,Ammonium tetrathiomolybdate,NSC 286644,ATTM,四硫钼酸铵,Coprexa	Others	Others
	Tiomolibdate diammonium (NSC-286644) 是超氧化物歧化酶 1 (SOD1) 的抑制剂，具有抗血管生成和抗肿瘤活性。 Tiomolibdate diammonium 抑制铜酶的活性，包括 SOD1 和 COX。
T19023	Lucigenin NSC-151912,L-6868,光泽精	Others	Others
	Lucigenin (NSC-151912) 是化学发光探针，可用于检测内源性产生的超氧阴离子自由基在细胞的存在。
TP1915	Boc-MLF	Others	Others
	Boc-MLF 是甲酰肽受体 1 (FPR1) 的拮抗剂。它减少 fMLF 诱导的超氧化物产生，EC50 为 0.63 μM。几乎完全阻断 fMLF 刺激的初级颗粒胞吐作用。
TP2321L	H-PRO-HIS-CYS-LYS-ARG-MET-OH acetate H-PRO-HIS-CYS-LYS-ARG-MET-OH acetate（159147-88-3 free base)	Others	Others
	H-PRO-HIS-CYS-LYS-ARG-MET-OH acetate（159147-88-3 free base) 通过与活性氧物质（如超氧化物和羟基自由基）反应而起到抗氧化剂的作用。
T22739	DMPO 5,5-二甲基-1-吡咯啉-N-氧化物,5,5-Dimethyl-1-pyrroline N-oxide	Others	Others
	DMPO (5,5-Dimethyl-1-pyrroline N-oxide) 是一种亲水自旋诱捕剂，具有细胞渗透性。DMPO 可用于超氧化物检测，可检测超氧阴离子和羟自由基。
T14341	ATN-224 四硫钼酸二胆碱,Bis(choline)tetrathiomolybdate	Others	Others
	ATN-224 (Bis(choline)tetrathiomolybdate) 抑制内皮细胞中的 SOD1 活性，这种作用呈剂量依赖性，IC50 为 17.5±3.7 nM。 ATN-224 是一种口服 Cu2+/Zn2+-超氧化物歧化酶 1 (SOD1) 抑制剂。
T13112	Tat-NR2B9c Tat-NR2Bct,NA-1	NO Synthase; iGluR	Immunology/Inflammation; Membrane transporter/Ion channel; Neuroscience
	Tat-NR2B9c (NA-1) 是一种突触后密度-95（PSD-95）抑制剂，具有神经保护和抗癫痫作用。Tat-NR2B9c 可抑制PSD-95d2、 PSD-95d1 和 PSD-95，可阻止NMDA诱导的神经元NADPH氧化酶的激活，从而阻断超氧化物的产生，可减少中风后急性期的缺血性损伤。
T20067	WST-1 WST 1
	WST-1 是一种具有细胞毒性的水溶性四唑盐，诱导细胞内线粒体脱氢酶进行 NADH 依赖性酶解反应，释放出水溶性甲基苯产物。WST-1 可通过检测吸收值来检测细胞增殖和细胞活性，可用于WST-1平板测定法测定超氧化物歧化酶活性。
T33412	MitoPQ MitoParaquat	Glucokinase; transporter	Metabolism
	MitoPQ (MitoParaquat) 是一个线粒体靶向的小分子化合物。MitoPQ 选择性加强线粒体超氧化物和过氧化氢的含量，抑制胰岛素刺激的葡萄糖摄取和葡萄糖转运蛋白 4 (GLUT4）向脂肪细胞和肌管中质膜的易位。MitoPQ 可用于研究线粒体氧化应激与调节的 GLUT4 转运。
T39965	NF-κΒ activator 1	NF-κB	NF-κB
	NF-κΒ activator 1 可激活NF-κΒ基因，EC50 为 0.9 μM。NF-κB 作为一种调控细胞增殖和细胞存活的基因被真核细胞广泛应用。NF-κΒ activator 1 可诱导超氧化物歧化酶 (SOD)2 mRNA 表达。
T19032	Nitro blue tetrazolium chloride NBT,氯化硝基四氮唑兰	NO Synthase	Immunology/Inflammation
	Nitro blue tetrazolium chloride (NBT) 是一种脱氢酶底物，能够与碱性磷酸酶底物 BCIP 一起用于 western blotting 和免疫组化染色。
T7575L1	[Sar1, Ile8]-Angiotensin II acetate	RAAS	Endocrinology/Hormones
	[Sar1, Ile8]-Angiotensin II acetate 可激活 NADPH 和 NADH 氧化酶，并刺激血管平滑肌细胞中超氧阴离子的形成。 [Sar1, Ile8]-Angiotensin II acetate 对血管平滑肌有多种作用，包括正常动脉的收缩和培养细胞或病变血管的肥大或增生。
T35689	MTP 131 acetate	Others	Others
	MTP 131 acetate 是一种小的线粒体靶向四肽。
T20094	Adrenochrome Adraxone	Antioxidant	oxidation-reduction
	Adrenochrome (Adraxone) 是一种细胞毒性分子，可用于杀死细菌。Adrenochrome 是 Epinephrine 的氧化产物。Adrenochrome 是一种可作用于大鼠心脏的冠状动脉收缩化合物，与心脏毒性有关，可用于确定超氧化物歧化酶的活性。Adrenochrome 与可用于神经系统疾病研究，是拟精神病的潜在药物。
T38164	MnTBAP chloride Mn(III)TBAP	Others	Others
	MnTBAP chloride (Mn(III)TBAP) 是一种具有细胞渗透性的超氧化物歧化酶 (SOD) 模拟物和过氧亚硝酸盐清除剂，能使SOD-大肠杆菌的加倍时间减少了2倍。 MnTBAP chloride 通过上调 BMPR-II 和抑制 NFκB 信号传导展现抗炎作用。MnTBAP chloride 是一种锰卟啉配合物，具有抗氧化性能，具有用于研究慢性肾脏疾病 (CKDs) 纤维化反应的潜力。
T34556	SC 55858 SC-55858,SC55858	Others	Others
	SC 55858 is a superoxide dismutase mimetic.
T36501	CYPMPO RR 071	Others	Others
	CYPMPO is a free radical spin trap with excellent trapping capabilities toward hydroxyl and superoxide radicals in biological and chemical systems. Decay of the superoxide adduct of CYPMPO proceeds in an apparent first order fashion with half-lives of 15 and 51 minutes in a UV-illuminated hydrogen peroxide solution and a hypoxanthine/xanthine oxidase system, respectively. CYPMPO traps superoxide radicals generated by bovine neutrophils as effectively as DEPMPO.[1] The high melting point (126°C),...
T22773	EUK 124	Others	Others
	EUK 124 is an inhibitor of superoxide-mediated reduction of an electron acceptor.
T39205	HKSOX-1	Others	Others
	HKSOX-1 is a fluorescent probe which is used for imaging and detection of endogenous superoxide in live cells and in vivo. HKSOX-1 exhibits excellent selectivity and sensitivity towards superoxide anion radical.
T22772	EUK 118	Others	Others
	EUK 118 is an inhibitor of superoxide-mediated reduction of an electron acceptor.
T39763	Rucosopasem manganese GC4711	Others	Others
	Rucosopasem manganese (GC4711) is a potent, selective superoxide dismutase (SOD) mimetic capable of efficiently converting superoxide to hydrogen peroxide. This compound, specifically designed for research purposes, holds promise in cancer-related studies.
T35965	MitoTEMPOL	Others	Others
	MitoTEMPOL is a mitochondria-targeting superoxide dismutase mimetic that reduces mitochondrial O2- to H2O2. Like the related compound MitoTEMPO , MitoTEMPOL combines an antioxidant moiety (here, TEMPOL, also known as 4-hydroxy-TEMPO) with the lipophilic cation triphenylphosphonium, which allows it to pass through lipid bilayers and accumulate in mitochondria. MitoTEMPOL has been used to elucidate the role of mitochondria-derived superoxide in mitochondrial, cellular, and whole animal signaling.
T25118	Avasopasem manganese	Others	Others
	Avasopasem manganese is a drug candidate of superoxide dismutase mimetic.
T71957	Cupferron	Others	Others
	Cupferron is a superoxide dismutase inhibitor.
T35966	Mn(III)TMPyP	Others	Others
	Mn(III)TMPyP is a manganese-porphyrin which acts as a superoxide dismutase (SOD) mimetic and peroxynitrite decomposition catalyst. SOD mimetics described to date are unstable and are capable of catalyzing undesired side-reactions in addition to the dismutation of the superoxide radical (O2-). Mn(III)TMPyP is an SOD mimetic with increased stability to pH and hydrogen peroxide. The rate constant for superoxide dismutation and peroxynitrite decomposition are 3.9 x 107 M-1s-1 and ~2 x 106 M-1s-1, re...
T70056	Moschamine	Others	Others
	Moschamine is an inhibitor of mitochondrial superoxide overproduction.
T19024	MCLA hydrochloride	Others	Others
	MCLA hydrochloride, a chemiluminescent compound, can be used to quantify aqueous concentrations of superoxide.
T7348	Imisopasem manganese M40403,伊米帕锰	Others	Others
	Imisopasem manganese (M40403) is a manganese superoxide MnSOD non-peptidyl mimetic.
T35964	MitoTEMPO hydrate	Others	Others
	MitoTEMPO is a mitochondria-targeted superoxide dismutase mimetic that possesses superoxide and alkyl radical scavenging properties.[1] This compound combines the antioxidant piperidine nitroxide TEMPO with the lipophilic cation triphenylphosphonium, which allows it to pass through lipid bilayers and accumulate in mitochondria. Mitochondrial targeting of superoxide scavenging via mitoTEMPO has been examined for potential therapeutic benefit to a variety of mitochondrial dysfunctions arising from...
T24817	Otaplimastat J3.046.690J,SP8203,SP-8203,SP 8203	Others	Others
	SP-8203 is a reactive oxygen species inhibitor and superoxide dismutase stimulant.
T10253	AD 0261	Others	Others
	AD 0261 is a radical scavenger. It has a strong inhibitory action on the generation of lipid peroxides and superoxide anions.
T71226	Opc 15161	Others	Others
	Opc 15161 is a degradation product of OPC-15160 and superoxide inhibitor.
T35962	MitoPBN	Others	Others
	MitoPBN is a mitochondria-targeted antioxidant. It accumulates in the mitochondria following the generation of a mitochondrial membrane potential by succinate, an effect that is blocked by addition of the mitochondrial membrane potential uncoupler FCCP . MitoPBN inhibits superoxide activation of mitochondrial uncoupling protein 1 (UCP1), UCP2, and UCP3 when used at a concentration of 250 nM in vitro but does not react with superoxide. It traps hydroxyl (IC50 = ~77 μM) and carbon-centered radical...
T14036	3',4'-Dihydroxyflavonol DiOHF	Others	Others
	3',4'-Dihydroxyflavonol (DiOHF) is an efficient antioxidant that diminishes superoxide levels and enhances nitric oxide (NO) functionality in the mesenteric arteries of diabetic rats[1].
T40972	1-Oleoyl-2-acetyl-sn-glycerol	Others	Others
	1-Oleoyl-2-acetyl-sn glycerol, a synthetic, cell-permeable diacylglycerol analog, activates calcium-dependent protein kinase C (PKC) and induces superoxide production.
T23810	BMX-001 MnTnBuOE-3-PyP 5+,manganese butoxyethyl pyridyl porphyrin,BMX001,manganese (III) ortho N-butoxyethylpyridylporphyrin	Others	Others
	BMX-001 is a third-generation, cationic, lipophilic, manganese (Mn), and porphyrin-based mimetic of the human mitochondrial manganese superoxide dismutase (MnSOD). It also has antioxidant and potential chemoprotective activities.
T34472	S1QEL S-1QEL,S1 QEL,S 1QEL,S1QEL1.1,S1-QEL	Others	Others
	S1QEL is a suppressor of mitochondrial respiratory complex I site IQ electron leak which suppresses superoxide and/or H2O2 production without altering oxidative phosphorylation.
T75342	MitoSOX Red	Reactive Oxygen Species; Mitochondrial Metabolism; Autophagy	Autophagy; Immunology/Inflammation; Metabolism; NF-κB
	MitoSOX Red 是一种具有特异性和细胞膜渗透性且靶向活细胞线粒体的新型荧光探针。MitoSOX Red 进入线粒体后会被超氧化物氧化，而不会被其他 ROS 或 RNS 生成系统氧化。MitoSOX Red 随后与线粒体内核酸结合，产生强红色荧光。MitoSOX Red 可以作为荧光指示剂，特异性检测超氧化物。超氧化物歧化酶 (Superoxide dismutase，SOD) 能够预防 MitoSOX Red 氧化。

化合物

Superoxide dismutase

Cat.No: T78346

Synonym: SOD

Target: Others

Manganese(salen) chloride

Cat.No: T40612

Synonym: EUK-8

Target: Others

Cat.No: T8531

Synonym: 2,4,6-三甲基-N-[3-(三氟甲基)苯基]苯磺酰胺

Target: Apoptosis, Phospholipase

Esomeprazole Magnesium

Cat.No: T2686

Synonym: (S)-Omeprazole magnesium,NEXIUM,埃索美拉唑镁,(-)-Omeprazole magnesium

Target: ATPase, Proton pump

Nitrosoglutathione

Cat.No: T19930

Synonym: S-Nitrosoglutathione,S-亚硝基谷胱甘肽,SNOG,Glutathione thionitrite,GSNO

Target: RAAS, NO Synthase

Esomeprazole Magnesium trihydrate

Cat.No: T8386

Synonym: 埃索美拉唑镁三水合物,埃索美拉唑镁(三水),(S)-Omeprazole magnesium trihydrate

Target: Proton pump

Cat.No: T6495

Synonym: EUK 134,乙基双亚氨基甲基愈创木酚锰氯化物

Target: Beta Amyloid

Cat.No: T19428

Target: Reactive Oxygen Species, Mitochondrial Metabolism

Dihydroethidium

Cat.No: T2021

Synonym: 二氢乙锭,PD-MY 003,Hydroethidine

Target: Others

Cat.No: T6699

Synonym: TMPN,Tanol,4-Hydroxy-TEMPO,阻聚剂701

Target: Reactive Oxygen Species, ROS, Autophagy

Cat.No: T40795

Target: Reactive Oxygen Species

Cat.No: T5426

Target: Reactive Oxygen Species, ROS

Tiomolibdate diammonium

Cat.No: T19668

Synonym: Ammonium molybdenum sulfide,Ammonium tetrathiomolybdate,NSC 286644,ATTM,四硫钼酸铵,Coprexa

Target: Others

Cat.No: T19023

Synonym: NSC-151912,L-6868,光泽精

Target: Others

Cat.No: TP1915

Target: Others

H-PRO-HIS-CYS-LYS-ARG-MET-OH acetate

Cat.No: TP2321L

Synonym: H-PRO-HIS-CYS-LYS-ARG-MET-OH acetate（159147-88-3 free base)

Target: Others

Cat.No: T22739

Synonym: 5,5-二甲基-1-吡咯啉-N-氧化物,5,5-Dimethyl-1-pyrroline N-oxide

Target: Others

Cat.No: T14341

Synonym: 四硫钼酸二胆碱,Bis(choline)tetrathiomolybdate

Target: Others

Cat.No: T13112

Synonym: Tat-NR2Bct,NA-1

Target: NO Synthase, iGluR

Cat.No: T20067

Synonym: WST 1

Cat.No: T33412

Synonym: MitoParaquat

Target: Glucokinase, transporter

NF-κΒ activator 1

Cat.No: T39965

Target: NF-κB

Nitro blue tetrazolium chloride

Cat.No: T19032

Synonym: NBT,氯化硝基四氮唑兰

Target: NO Synthase

[Sar1, Ile8]-Angiotensin II acetate

Cat.No: T7575L1

Target: RAAS

MTP 131 acetate

Cat.No: T35689

Target: Others

Cat.No: T20094

Synonym: Adraxone

Target: Antioxidant

MnTBAP chloride

Cat.No: T38164

Synonym: Mn(III)TBAP

Target: Others

Cat.No: T34556

Synonym: SC-55858,SC55858

Target: Others

Cat.No: T36501

Synonym: RR 071

Target: Others

Cat.No: T22773

Target: Others

Cat.No: T39205

Target: Others

Cat.No: T22772

Target: Others

Rucosopasem manganese

Cat.No: T39763

Synonym: GC4711

Target: Others

Cat.No: T35965

Target: Others

Avasopasem manganese

Cat.No: T25118

Target: Others

Cat.No: T71957

Target: Others

Cat.No: T35966

Target: Others

Cat.No: T70056

Target: Others

MCLA hydrochloride

Cat.No: T19024

Target: Others

Imisopasem manganese

Cat.No: T7348

Synonym: M40403,伊米帕锰

Target: Others

MitoTEMPO hydrate

Cat.No: T35964

Target: Others

Cat.No: T24817

Synonym: J3.046.690J,SP8203,SP-8203,SP 8203

Target: Others

Cat.No: T10253

Target: Others

Cat.No: T71226

Target: Others

Cat.No: T35962

Target: Others

3',4'-Dihydroxyflavonol

Cat.No: T14036

Synonym: DiOHF

Target: Others

1-Oleoyl-2-acetyl-sn-glycerol

Cat.No: T40972

Target: Others

Cat.No: T23810

Synonym: MnTnBuOE-3-PyP 5+,manganese butoxyethyl pyridyl porphyrin,BMX001,manganese (III) ortho N-butoxyethylpyridylporphyrin

Target: Others

Cat.No: T34472

Synonym: S-1QEL,S1 QEL,S 1QEL,S1QEL1.1,S1-QEL

Target: Others

Cat.No: T75342

Target: Reactive Oxygen Species, Mitochondrial Metabolism, Autophagy

Cat. No.	Product Name	Target	Signaling Pathways
T9057	norbergenin	IL Receptor; TNF; Reactive Oxygen Species	Apoptosis; Immunology/Inflammation; Metabolism; NF-κB
	Norbergenin 是一种 bergenin 的邻去甲基衍生物，可从白芍的根茎中分离得到，具有中等的抗氧化活性。
T3S0218	Thonningianin A	Apoptosis; Others	Apoptosis; Others
	Thonningianin A 是从非洲草药通宁宁的甲醇提取物中，分离得到的一种鞣花素，具有抗癌和抗氧化性，涉及自由基清除、抗超氧化物形成和金属螯合。
T2223	Kinetin 激动素,6-Furfuryladenine,6-糠氨基嘌呤,N6-Furfuryladenine	Others	Others
	Kinetin (N6-Furfuryladenine) 是 N6-取代腺嘌呤衍生物细胞分裂素家族成员，其中细胞分裂素是一种参与细胞分裂、分化等生理过程的植物生长激素。它具有抗衰老活性。
T4S0039	Baimaside 白麻苷,Quercetin-3-O-sophoroside,Quercetin 3-beta-D-sophoroside	Others	Others
	Quercetin-3-O-sophoroside 是一种超氧阴离子的清除剂，分离自A. venetum的花中。
TN1916	Matairesinol 罗汉松树脂酚	ATPase; p38 MAPK; ROS	Immunology/Inflammation; MAPK; Membrane transporter/Ion channel
	Matairesinol has radical and superoxide scavenging activities,; it also has anti-angiogenic activity by suppressing mROS signaling , can decrease hypoxia-inducible factor-1α± in hypoxic HeLa cells.
T4931	Dihydroxyfumaric acid hydrate	Others; Endogenous Metabolite	Metabolism; Others
	Dihydroxyfumaric acid hydrate 是内源性代谢产物的一种。
TJS1382	Taraxerone 蒲公英赛酮	Dehydrogenase	Metabolism
	Taraxerone 是分离自景天的天然产物。它可以增强乙醇脱氢酶和乙醛脱氢酶活性，EC50分别为 512.42 μM 和 500.16 μM。
T6S1440	Loganic acid 马钱苷酸,Loganate	Others	Others
	Loganic acid (Loganate) 是从山茱萸果实中分离得到的环烯醚萜。它具有很强的自由基清除活性，对重金属介导的毒性有显著的细胞保护作用。它能调节饮食引起的动脉粥样硬化和氧化还原状态。
T5543	TriacetonaMine 四甲基哌啶酮,Odoratine,tempidon,tmpone,Vincubine,2,2,6,6-Tetramethyl-4-piperidinone	Others	Others
	TriacetonaMine (Vincubine) 是一种合成医药产品、农药和聚合物光稳定剂的中间体。它是热解油的主要组分。它是植物和真菌提取物的人工制品，使用丙酮和氢氧化铵，或在分离过程的不同步骤中天然出现铵盐。
T5S1897	Linderalactone	Apoptosis; Others; JAK	Angiogenesis; Apoptosis; Chromatin/Epigenetic; JAK/STAT signaling; Others; Stem Cells
	Linderalactone 是从乌药中分离出来的一种倍半萜烯内酯，通过调节凋亡相关蛋白的表达和抑制 JAK/STAT 信号通路来抑制癌细胞生长。它以 IC50值为 15 µM 来抑制肺癌 A-549 细胞的增殖。
TN6647	4-O-Cinnamoylquinic acid 金银花	Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation
	4-O-Cinnamoylquinic acid 是从 Casearia grewiifolia 干果中提取出来的小分子化合物，对前列腺素有抑制作用，抑制人中性粒细胞中超氧阴离子的生成。
T16527	Phytic acid dodecasodium salt hydrate 植酸十二钠盐,myo-Inositol, hexakis(dihydrogen phosphate) dodecasodium salt hydrate,Inositol hexaphosphate dodecasodium salt hydrate	Others; Xanthine Oxidase; Endogenous Metabolite	Metabolism; Others
	Phytic acid dodecasodium salt hydrate (myo-Inositol, hexakis(dihydrogen phosphate) dodecasodium salt hydrate) 是种子和谷物的磷储存化合物。 Phytic acid dodecasodium salt hydrate 抑制酶促超氧化物源黄嘌呤氧化酶，IC50 为 6 mM，并具有抗氧化、神经保护和抗炎作用。
T5S2254	Swertianolin Bellidifolin-8-O-Glucoside,当药醇苷	Others; HBV; Antibacterial; AChE	Microbiology/Virology; Neuroscience; Others
	Swertianolin (Bellidifolin-8-O-Glucoside) 是从Gentianella Acuta 分离得到的一种黄酮，具有抗 HBV 和抗菌活性，可抑制乙酰胆碱酯酶。
TN4614	N-Methylflindersine N-甲基芸香碱,2,2,6-trimethylpyrano[3,2-c]quinolin-5-one,2,2,6-Trimethyl-2H,5H-pyrano[3,2-c]quinolin-5-one	Others	Others
	N-Methylflindersine (2,2,6-Trimethyl-2H,5H-pyrano[3,2-c]quinolin-5-one) 对盐水虾幼虫有很强的毒性，LD(50) 值为 1.39 microg/ml。它还展示了对 N-甲酰甲硫氨酰苯丙氨酸诱导的超氧化物产生的有效抑制作用，IC(50) 值小于 12 microM。
T5S0281	Tubuloside A	NOS	Immunology/Inflammation
	Tubuloside A 是一种苯乙醇苷，具有抗氧化活性和保肝活性。
T2S0731	Trilobatin 三叶苷,三叶甙,P-Phlorizin	Amylase	Metabolism
	Trilobatin (P-Phlorizin) 是源自Lithocarpus polystachyusRehd 的甜味剂，是一种HIV-1抑制剂，靶向 Gp41 包膜蛋白，具有神经保护作用。它还是SGLT1/2抑制剂，可选择性诱导人肝母细胞瘤细胞增殖。
TJS0315	4-Methyldaphnetin 7,8-Dihydroxy-4-methylcoumarin,4-甲基瑞香素,DHMC,7,8-二羟基-4-甲基香豆素	Apoptosis; Lipoxygenase	Apoptosis; Metabolism
	4-Methyldaphnetin (DHMC) 是一种合成 4-甲基香豆素衍生物的前体。它对几种肿瘤细胞株具有选择性的抗增殖和诱导凋亡的作用。它能够清除自由基，显著抑制膜脂过氧化。
T8280	Deacetylasperulosidic Acid 去乙酰基车叶草苷酸,去乙酰车叶草苷酸,Desacetyl asperulosidic acid	IL Receptor; Interleukin	Immunology/Inflammation
	Deacetylasperulosidic Acid 是海巴戟果实的主要植物化学成分。它能够防止体外 4-硝基喹啉1-氧化物诱导的 DNA 损伤，抑制 IL-2的产生以及自然杀伤细胞的活化。它具有抗原活性，抑制仓鼠卵巢细胞和小鼠中染色体畸变的诱导。它可增加超氧化物歧化酶活性，从而具有抗氧化活性。
TN3469	Aucuparin 2,6-dimethoxy-4-phenylphenol	NADPH-oxidase	Immunology/Inflammation
	Aucuparin (2,6-dimethoxy-4-phenylphenol) 是一种植物抗菌素，具有抗炎活性。在博来霉素 (BLM) 诱导的肺纤维化小鼠模型中，Aucuparin 抑制肺纤维化。在经ABTS 和FRAP 测定显示出明显的清除活性。 Aucuparin 对fmlp 诱导的人中性粒细胞产生超氧化物具有明显的抑制作用，其IC50为17.0μM。
T3388	Calycosin-7-O-β-D-glucoside 毛蕊异黄酮苷,calycosin-7-O-beta-D-glucopyranoside,Calycosin-7-O-beta-D-glucoside	MMP; Reactive Oxygen Species	Immunology/Inflammation; Metabolism; NF-κB; Proteases/Proteasome
	Calycosin-7-O-β-D-glucoside (calycosin-7-O-beta-D-glucopyranoside) 是一种异黄酮，从黄芪中分离得到。它具有多种生物活性，包括心脏保护、神经保护、抗炎和抗氧化作用。
T2836	Isorhamnetin 3-methylquercetin,3'-Methylquercetin,Isorhamnetol,异鼠李素,3'-Methoxyquercetin	MEK; PI3K; Endogenous Metabolite	MAPK; Metabolism; PI3K/Akt/mTOR signaling
	Isorhamnetin (3-methylquercetin) 是从中草药沙棘中提取的一种类黄酮，可通过抑制MEK1和PI3K 来抑制皮肤癌。
TN6931	Anemarrhenasaponin Ia 知母皂苷IA	Others	Others
	Anemarrhenasaponin Ia ((2S,3R,4S,5S,6R)-2-{[(2R,3R,4S,5R,6R)-4,5-dihydroxy-2-{[(1R,3R,4R,7S,9S,12S,13S,16S,18R)-3-hydroxy-6-methoxy-7,9,13-trimethyl-6-(3-methylbutyl)-5-oxapentacyclo[10.8.0.02,?.0?,?.013,1?]icosan-16-yl]oxy}-6-(hydroxymethyl)oxan-3-yl]oxy}-6-(hydroxymethyl)oxan) 具有抗炎活性。Anemarrhenasaponin Ia 具有抗炎作用，从知母根茎中分离得到。 Anemarrhenasaponin Ia 抑制 N-甲酰-甲硫氨酰-亮氨酰-苯丙氨酸 (fMLP) 诱导的超氧化物的进一步产生。
TN3069	4beta-Carboxy-19-nortotarol	NADPH-oxidase	Immunology/Inflammation
	4 beta-Carboxy-19-nortotarol can inhibit microsomal lipid peroxidation induced by Fe(III)-ADP/NADPH and mitochondrial lipid peroxidation induced by Fe(III)-ADP/ NADH, it inhibits linoleic acid autoxidation but not generation of superoxide anion.
TN2888	3,4-Secolupa-4(23),20(29)-diene-3,28-dioic acid	Others	Others
	3,4-Secolupa-4(23),20(29)-diene-3,28-dioic acid exhibits potent inhibition of superoxide-anion generation with 86.9 ± 2.8% inhibition at 1 uM.
TN5156	Totaradiol	NADPH-oxidase	Immunology/Inflammation
	Totaradiol shows antioxidant activity, it can inhibit linoleic acid autoxidation but not generation of superoxide anion. Totaradiol exhibits cytotoxic activity against the A2780 ovarian cancer cell line.
TN4214	Hispanone
	Hispanone possesses anti-inflammatory activity, it shows inhibition of superoxide anion generation and elastase release.
T79946	Isorabaichromone	Reactive Oxygen Species	Immunology/Inflammation; Metabolism; NF-κB
	Isorabaichromone 为强效抗氧化剂，能有效清除 DPPH 自由基及超氧阴离子。
TN2134	Raddeanoside 20	Others	Others
	Raddeanoside 20 can slightly suppress the superoxide generation induced by N-formyl-methionyl-leucyl-phenylalanine (fMLP) in a concentration dependent manner.
TN5105	Taxagifine	Others	Others
	Taxagifine shows cytotoxic activity toward HepG2 cells; it can suppress the superoxide generation induced by N-formyl-methionyl-leucyl-phenylalanine (fMLP) and arachidonic acid (AA) in a concentration-dependent manner.
TN3744	Cyclomorusin	NOS; AChR	Immunology/Inflammation; Neuroscience
	Cyclomorusin exhibits competitive inhibition toward monophenolase activity of mushroom tyrosinase, the IC50 value of 0.092 microM. It evokes the stimulation of superoxide anion generation in fMLP-stimulated rat neutrophils. Cyclomorusin , neocyclomorusin
TN4437	Licorisoflavan A	MMP; IL Receptor; NF-κB; DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Immunology/Inflammation; NF-κB; Proteases/Proteasome
	Licorisoflavan A shows weak scavenging activity against superoxide anion radical, it and licoricidin have potential for the development of novel host-modulating strategies for the treatment of cytokine and/or MMP-mediated disorders such as periodontitis.L
T75619	Aristololactam IIIa	Others	Others
	Aristololactam IIIa 对超氧阴离子生成和弹性蛋白酶的释放有显著抑制作用，其 IC50值分别为 0.12 和 0.20 μg/mL。
TN4045	Evofolin C	Antifection	Microbiology/Virology
	Evofolin C and its acetate show strong antifungal and antibacterial activity. Evofolin C exhibits potent inhibition against N-formylmethionylleucylphenylalanine-induced superoxide production with IC(50) values less than 12 microM.
T83000	Antitumor agent-89
	Antitumor agent-89（Compd OTS-5）为源自天然的化合物，其活性表现为轻度抑制fMLP诱导的超氧化物生成。
TN2973	3'-O-Methylmurraol
	3'-O-Methylmurraol may have potential anti-inflammatory activity, it exhibits inhibition (IC50 ≤ 7.31 ug/mL) of superoxide anion generation by human neutrophils in response to formyl-l-methionyl-l-leucyl-l-phenylalanine/cytochalasin B (fMLP/CB).
TN1503	Cistanoside F 肉苁蓉苷F,肉苁蓉苷 F	NADPH-oxidase	Immunology/Inflammation
	Cistanoside F shows vasorelaxant, and antioxidative effects, it shows a strong free radical scavenging activity on 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical and xanthine/xanthine oxidase (XOD) generated superoxide anion radical (O2-.).
TN5104	Taxacin	Others	Others
	Taxacin shows strong inhibitory effects on platelet aggregation induced by arachidonic acid (IC(50):21.9 microM). Taxacin can suppress the superoxide generation induced by N-formyl-methionyl-leucyl-phenylalanine (fMLP) and arachidonic acid (AA) in a conce
TN1958	Mulberroside F 桑皮苷F,桑皮苷 F	Tyrosinase	Proteases/Proteasome
	Mulberroside F shows inhibitory effects on tyrosinase activity and on the melanin formation of melan-a cells, it also exhibits superoxide scavenging activity that is involved in the protection against auto-oxidation, suggests that mulberroside F may be us
T82724	Chrysophanol 8-O-β-D-(6′-O-galloyl)glucopyranoside
	Chrysophanol 8-O-β-D-(6’-O-galloyl)glucopyranoside为一种从Rheum undulatum L. 分离得到的蒽醌类葡萄糖苷，具备显著的DPPH自由基与?O2-清除作用。
TN2408	Evofolin B	Cannabinoid Receptor	GPCR/G Protein
	Evofolin B 是从Zanthoxylum ailanthoides 的茎皮中分离出来的天然化合物。Evofolin B 对人类中性粒细胞对甲酰-L-蛋氨酸-L-亮氨酸-L-苯丙氨酸/cytochalasin B（fMLP/CB）产生的超氧阴离子有抑制作用。
TN5221	(-)-Variabilin
	Variabilin, a novel inhibitor of human platelet aggregation, it is a potent RGD (Arg-Gly-Asp)-containing antagonist of the fibrinogen receptor glycoprotein IIb-IIIa (GPIIb-IIIa; αIIbβ3) and the vitronectin receptor αvβ3.Variabilin is also an antimicrobial furanosesterterpene. Variabilin is an inhibitor of human secretory and cytosolic phospholipase A2 (PLA2) activities that controls eicosanoid production in vitro and in vivo, inhibits neutrophil degranulation and superoxide generation in vitro a...
T38262	Sphingosine (d14:1)	Others	Others
	Sphingosine (d14:1) is a bioactive sphingolipid that has been found in B. mori (silkworm), P. clarkii (crayfish), and A. aurita (jellyfish) extracts. It increases the germination rate of N. rileyi, an entomopathogenic fungus, with an EC50 value of 10.2 nM. Sphingosine (d14:1) inhibits protein kinase C (PKC) in vitro (IC50 = 7.3 mol%) as well as superoxide generation induced by phorbol 12-myristate 13-acetate in neutrophils and reduces growth of CHO cells (IC50s = 19 and 8 μM, respectively).
TN2243	Sugiol 10-Deoxoxanthoperol	IL Receptor; TNF; ROS	Apoptosis; Immunology/Inflammation
	Sugiol (10-Deoxoxanthoperol) 是一种枞烷二萜，可从台湾板栗树 (Calocedrus formosana) 的树皮中分离出来。Sugiol 具有抗炎活性，可有效减少脂多糖 (LPS) 刺激巨噬细胞后的活性氧 (ROS) 产生。
TN3706	Coronarin A
	Coronarin, A, B, C, and D are cytotoxic prinicples from the rhizomes of Hedychium coronarium, Zingiberaceae. Coronarin A exhibits good growth inhibition activities on HUVEC proliferation, it effectively suppresses the growth factor induced tube formation
T79757	Meliadubin B	NO Synthase	Immunology/Inflammation
	Meliadubin B是一种具有显著生物活性的天然三萜类化合物。它能有效抑制人中性粒细胞中超氧阴离子的产生，具有炎症抑制作用（EC50为5.54 μM）。同时，Meliadubin B也能抑制诱导型一氧化氮合酶的活性。此外，该化合物还能对抗水稻病原真菌Magnaporthe oryzae，显示出显着的抑制效果，其IC50为182.50 μM。

天然产物

Cat.No: T9057

Target: IL Receptor, TNF, Reactive Oxygen Species

Thonningianin A

Cat.No: T3S0218

Target: Apoptosis, Others

Cat.No: T2223

Synonym: 激动素,6-Furfuryladenine,6-糠氨基嘌呤,N6-Furfuryladenine

Target: Others

Cat.No: T4S0039

Synonym: 白麻苷,Quercetin-3-O-sophoroside,Quercetin 3-beta-D-sophoroside

Target: Others

Cat.No: TN1916

Synonym: 罗汉松树脂酚

Target: ATPase, p38 MAPK, ROS

Dihydroxyfumaric acid hydrate

Cat.No: T4931

Target: Others, Endogenous Metabolite

Cat.No: TJS1382

Synonym: 蒲公英赛酮

Target: Dehydrogenase

Cat.No: T6S1440

Synonym: 马钱苷酸,Loganate

Target: Others

Cat.No: T5543

Synonym: 四甲基哌啶酮,Odoratine,tempidon,tmpone,Vincubine,2,2,6,6-Tetramethyl-4-piperidinone

Target: Others

Cat.No: T5S1897

Target: Apoptosis, Others, JAK

4-O-Cinnamoylquinic acid

Cat.No: TN6647

Synonym: 金银花

Target: Prostaglandin Receptor

Phytic acid dodecasodium salt hydrate

Cat.No: T16527

Synonym: 植酸十二钠盐,myo-Inositol, hexakis(dihydrogen phosphate) dodecasodium salt hydrate,Inositol hexaphosphate dodecasodium salt hydrate

Target: Others, Xanthine Oxidase, Endogenous Metabolite

Cat.No: T5S2254

Synonym: Bellidifolin-8-O-Glucoside,当药醇苷

Target: Others, HBV, Antibacterial, AChE

N-Methylflindersine

Cat.No: TN4614

Synonym: N-甲基芸香碱,2,2,6-trimethylpyrano[3,2-c]quinolin-5-one,2,2,6-Trimethyl-2H,5H-pyrano[3,2-c]quinolin-5-one

Target: Others

Cat.No: T5S0281

Target: NOS

Cat.No: T2S0731

Synonym: 三叶苷,三叶甙,P-Phlorizin

Target: Amylase

4-Methyldaphnetin

Cat.No: TJS0315

Synonym: 7,8-Dihydroxy-4-methylcoumarin,4-甲基瑞香素,DHMC,7,8-二羟基-4-甲基香豆素

Target: Apoptosis, Lipoxygenase

Deacetylasperulosidic Acid

Cat.No: T8280

Synonym: 去乙酰基车叶草苷酸,去乙酰车叶草苷酸,Desacetyl asperulosidic acid

Target: IL Receptor, Interleukin

Cat.No: TN3469

Synonym: 2,6-dimethoxy-4-phenylphenol

Target: NADPH-oxidase

Calycosin-7-O-β-D-glucoside

Cat.No: T3388

Synonym: 毛蕊异黄酮苷,calycosin-7-O-beta-D-glucopyranoside,Calycosin-7-O-beta-D-glucoside

Target: MMP, Reactive Oxygen Species

Cat.No: T2836

Synonym: 3-methylquercetin,3'-Methylquercetin,Isorhamnetol,异鼠李素,3'-Methoxyquercetin

Target: MEK, PI3K, Endogenous Metabolite

Anemarrhenasaponin Ia

Cat.No: TN6931

Synonym: 知母皂苷IA

Target: Others

4beta-Carboxy-19-nortotarol

Cat.No: TN3069

Target: NADPH-oxidase

3,4-Secolupa-4(23),20(29)-diene-3,28-dioic acid

Cat.No: TN2888

Target: Others

Cat.No: TN5156

Target: NADPH-oxidase

Cat.No: TN4214

Isorabaichromone

Cat.No: T79946

Target: Reactive Oxygen Species

Raddeanoside 20

Cat.No: TN2134

Target: Others

Cat.No: TN5105

Target: Others

Cat.No: TN3744

Target: NOS, AChR

Licorisoflavan A

Cat.No: TN4437

Target: MMP, IL Receptor, NF-κB, DNA/RNA Synthesis

Aristololactam IIIa

Cat.No: T75619

Target: Others

Cat.No: TN4045

Target: Antifection

Antitumor agent-89

Cat.No: T83000

3'-O-Methylmurraol

Cat.No: TN2973

Cat.No: TN1503

Synonym: 肉苁蓉苷F,肉苁蓉苷 F

Target: NADPH-oxidase

Cat.No: TN5104

Target: Others

Cat.No: TN1958

Synonym: 桑皮苷F,桑皮苷 F

Target: Tyrosinase

Chrysophanol 8-O-β-D-(6′-O-galloyl)glucopyranoside

Cat.No: T82724

Cat.No: TN2408

Target: Cannabinoid Receptor

Cat.No: TN5221

Sphingosine (d14:1)

Cat.No: T38262

Target: Others

Cat.No: TN2243

Synonym: 10-Deoxoxanthoperol

Target: IL Receptor, TNF, ROS

Cat.No: TN3706

Cat.No: T79757

Target: NO Synthase

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPH-00052	Superoxide dismutase [Fe] Protein, Anabaena sp., Recombinant (His & KSI) sodB,Superoxide dismutase [Fe]	Anabaena	E. coli
	Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems. Superoxide dismutase [Fe] Protein, Anabaena sp., Recombinant (His & KSI) is expressed in E. coli expression system with N-6xHis-KSI tag. The predicted molecular weight is 16.4 kDa and the accession number is P83157.
TMPH-00469	SOD1 Protein, Danio rerio, Recombinant (His & Myc & SUMO) sod1,Superoxide dismutase [Cu-Zn]	Danio rerio (Zebrafish)	E. coli
	SOD1 Protein, Danio rerio, Recombinant (His & Myc & SUMO) is expressed in E. coli.
TMPJ-00105	SOD2 Protein, Human, Recombinant (His) Superoxide Dismutase [Mn] Mitochondrial,SOD2	Human	HEK293 Cells
	Superoxide Dismutase (SOD2) belongs to the iron/manganese superoxide dismutase family. SOD2 is a mitochondrial matrix protein that forms a homotetramer and binds one manganese ion per subunit. SOD2 transforms toxic superoxide, a byproduct of the mitochondrial electron transport chain into hydrogen peroxide and diatomic oxygen. It is reported that oxidative stress plays an essential role in the development of breast cancer, while SOD2 is one of the primary enzymes that directly convert potential ...
TMPJ-00104	SOD2 Protein, Human, Recombinant (E. coli, His) SOD2,Superoxide Dismutase [Mn] Mitochondrial	Human	E. coli
	Superoxide Dismutase (SOD2) is a number of the iron/manganese superoxide dismutase family. SOD2 is a mitochondrial protein that forms a homotetramer and binds one manganese ion per subunit. The SOD2 protein transforms toxic superoxide and a byproduct of the mitochondrial electron transport chain into hydrogen peroxide and diatomic oxygen. Genetic variation in SOD2 is associated with microvascular complications of diabetes type 6 (MVCD6), idiopathic cardiomyopathy (IDC), sporadic motor neuron dis...
TMPY-02044	SOD2 Protein, Human, Recombinant superoxide dismutase 2, mitochondrial,IPOB,MNSOD,MV...	Human	E. coli
	Superoxide dismutases (SOD) are important anti-oxidant enzymes that guard against superoxide toxicity. In humans, as in all mammals and most chordates, three forms of superoxide dismutase (SOD) are present: SOD1 is located in the cytoplasm, SOD2 in the mitochondria, and SOD3 is extracellular. Mitochondrial superoxide dismutase [SOD; manganese SOD (MnSOD) or SOD2] neutralizes highly reactive superoxide radical (O•-2), the first member in the plethora of mitochondrial reactive oxygen species.
TMPH-02918	SOD1 Protein, Mouse, Recombinant (His) Sod1,Superoxide dismutase [Cu-Zn]	Mouse	P. pastoris (Yeast)
	Destroys radicals which are normally produced within the cells and which are toxic to biological systems. SOD1 Protein, Mouse, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 17.8 kDa and the accession number is P08228.
TMPH-03378	SOD1 Protein, Rat, Recombinant (His) Sod1,Superoxide dismutase [Cu-Zn]	Rat	P. pastoris (Yeast)
	Destroys radicals which are normally produced within the cells and which are toxic to biological systems. SOD1 Protein, Rat, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 17.3 kDa and the accession number is P07632.
TMPH-03612	SodC Protein, Mycobacterium tuberculosis, Recombinant (His & Myc) Superoxide dismutase [Cu-Zn],sodC	Mycobacterium tuberculosis	E. coli
	Destroys radicals which are normally produced within the cells and which are toxic to biological systems. May play a role in favoring mycobacterial survival in phagocytes. SodC Protein, Mycobacterium tuberculosis, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 28.1 kDa and the accession number is P9WGE8.
TMPH-02917	SOD1 Protein, Mouse, Recombinant (E. coli, His) Superoxide dismutase [Cu-Zn],Sod1	Mouse	E. coli
	Destroys radicals which are normally produced within the cells and which are toxic to biological systems. SOD1 Protein, Mouse, Recombinant (E. coli, His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 19.8 kDa and the accession number is P08228.
TMPH-01318	SOD3 Protein, Human, Recombinant SOD3,Extracellular superoxide dismutase [Cu-Zn]	Human	E. coli
	Protect the extracellular space from toxic effect of reactive oxygen intermediates by converting superoxide radicals into hydrogen peroxide and oxygen. SOD3 Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 24.1 kDa and the accession number is P08294.
TMPH-01317	SOD3 Protein, Human, Recombinant (His) SOD3,Extracellular superoxide dismutase [Cu-Zn]	Human	E. coli
	Protect the extracellular space from toxic effect of reactive oxygen intermediates by converting superoxide radicals into hydrogen peroxide and oxygen. SOD3 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 28.1 kDa and the accession number is P08294.
TMPY-01585	SOD1 Protein, Human, Recombinant (His) SOD,homodimer,ALS,hSod1,IPOA,superoxide dismutase 1...	Human	E. coli
	SOD1 belongs to the Cu-Zn superoxide dismutase family. It binds copper and zinc ions and is one of two isozymes responsible for destroying free superoxide radicals in the body. The encoded isozyme is a soluble cytoplasmic protein, acting as a homodimer to convert naturally-occuring but harmful superoxide radicals to molecular oxygen and hydrogen peroxide. The other isozyme is a mitochondrial protein. Mutations in this gene have been implicated as causes of familial amyotrophic lateral sclerosis....
TMPH-01746	NOX4 Protein, Human, Recombinant (E. coli, His) Kidney superoxide-producing NADPH oxidase,NOX4,NADP...	Human	E. coli
	NOX4 Protein, Human, Recombinant (E. coli, His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 28.8 kDa and the accession number is Q9NPH5.
TMPH-01745	NOX4 Protein, Human, Recombinant (Cell-Free, His) NOX4,Kidney oxidase-1,Renal NAD(P)H-oxidase,Kidney super...	Human	E. coli
	NOX4 Protein, Human, Recombinant (Cell-Free, His) is expressed in E. coli expression system with N-10xHis tag. The predicted molecular weight is 69.8?kDa and the accession number is Q9NPH5.
TMPH-01744	NOX1 Protein, Human, Recombinant (His) NADH/NADPH mitogenic oxidase subunit P65-MOX,NADPH oxidase 1...	Human	E. coli
	NOH-1S is a voltage-gated proton channel that mediates the H(+) currents of resting phagocytes and other tissues. It participates in the regulation of cellular pH and is blocked by zinc. NOH-1L is a pyridine nucleotide-dependent oxidoreductase that generates superoxide and might conduct H(+) ions as part of its electron transport mechanism, whereas NOH-1S does not contain an electron transport chain. NOX1 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-10xHis t...
TMPY-02686	PON3 Protein, Human, Recombinant (S50N, His) paraoxonase 3	Human	Baculovirus Insect Cells
	PON3 was enriched in the mitochondria-associated membrane fraction of hepatocytes. PON3 deficiency resulted in impaired mitochondrial respiration, increased mitochondrial superoxide levels, and increased hepatic expression of inflammatory genes. PON3 deficiency did not influence atherosclerosis development on an apolipoprotein E null hyperlipidemic background, but it did lead to a significant 60% increase in atherosclerotic lesion size in Pon3KO mice on the C57BL/6J background when fed a cholate...
TMPH-03751	CYBB Protein, Human, Recombinant (His) NADPH oxidase 2,Heme-binding membrane glycoprotein gp91phox,...	Human	E. coli
	Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. It is the terminal component of a respiratory chain that transfers single electrons from cytoplasmic NADPH across the plasma membrane to molecular oxygen on the exterior. Also functions as a voltage-gated proton channel that mediates the H(+) currents of resting phagocytes. It participates in the regulation of cellular pH and is blocked by zinc.
TMPJ-00582	PRG3 Protein, Human, Recombinant (His) Prepro-MBPH,Prepro-Major Basic Protein Homolog,Eosinophil Ma...	Human	HEK293 Cells
	Proteoglycan 3, also known as Eosinophil major basic protein homolog, Prepro-major basic protein homolog, PRG3 and MBPH, contains one C-type lectin domain. Proteoglycans are a major component of the animal extracellular matrix. PRG3 localizes to the eosinophil secondary granule and is expressed in bone marrow, not detected in placenta. PRG3 has similar cytotoxic and cytostimulatory activities to PRG2/MBP. In vitro, PRG3 can stimulate neutrophil superoxide production and IL8 release, histamine an...
TMPH-01023	C5AR1 Protein, Human, Recombinant (Cell-Free, His) C5a anaphylatoxin chemotactic receptor 1,C5R1,C5a-R,C5a anap...	Human	E. coli
	Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a. The ligand interacts with at least two sites on the receptor: a high-affinity site on the extracellular N-terminus, and a second site in the transmembrane region which activates downstream signaling events. Receptor activation stimulates chemotaxis, granule enzyme release, intracellular calcium release and superoxide anion production. C5AR1 Protein, Human, Recombinant (Cell-Free, His) is expressed in E. coli expression syst...
TMPH-01022	C5AR1 Protein-VLP, Human, Recombinant (His) C5a anaphylatoxin chemotactic receptor 1,CD88,C5a anaphylato...	Human	HEK293 Cells
	Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a. The ligand interacts with at least two sites on the receptor: a high-affinity site on the extracellular N-terminus, and a second site in the transmembrane region which activates downstream signaling events. Receptor activation stimulates chemotaxis, granule enzyme release, intracellular calcium release and superoxide anion production. C5AR1 Protein-VLP, Human, Recombinant (His) is expressed in HEK293 mammalian cells with C-...
TMPH-01346	FPR1 Protein, Human, Recombinant (GST & His & Myc) FPR1,N-formylpeptide chemoattractant receptor,N-formyl pepti...	Human	E. coli
	High affinity receptor for N-formyl-methionyl peptides (fMLP), which are powerful neutrophil chemotactic factors. Binding of fMLP to the receptor stimulates intracellular calcium mobilization and superoxide anion release. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Receptor for TAFA4, mediates its effects on chemoattracting macrophages, promoting phagocytosis and increasing ROS release. FPR1 Protein, Human, Recombinant (GST & H...
TMPH-02658	FPR1 Protein, Mouse, Recombinant (GST & His & Myc) Fpr1,N-formylpeptide chemoattractant receptor,N-formyl pepti...	Mouse	E. coli
	High affinity receptor for N-formyl-methionyl peptides (fMLP), which are powerful neutrophil chemotactic factors. Binding of fMLP to the receptor stimulates intracellular calcium mobilization and superoxide anion release. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Receptor for TAFA4, mediates its effects on chemoattracting macrophages, promoting phagocytosis and increasing ROS release. FPR1 Protein, Mouse, Recombinant (GST & H...
TMPH-00794	Dps Protein, Helicobacter pylori, Recombinant (His & SUMO) napA,DNA protection during starvation protein,Bacterioferrit...	Helicobacter pylori	E. coli
	Protects DNA from oxidative damage by sequestering intracellular Fe(2+) ion and storing it in the form of Fe(3+) oxyhydroxide mineral. One hydrogen peroxide oxidizes two Fe(2+) ions, which prevents hydroxyl radical production by the Fenton reaction. Required for the survival in the presence of oxidative stress. Dps is also a virulence factor that activates neutrophils, mast cells and monocytes. It binds to neutrophil-glycosphingolipids and to sulfated carbohydrates on mucin. It might have a role...
TMPJ-00848	NCF1 Protein, Human, Recombinant (His) Nox-organizing protein 2/SH3 and PX domain-containing protei...	Human	E. coli
	Neutrophil cytosol factor 1( NCF1) is a 47 kDa cytosolic subunit of neutrophil NADPH oxidase. This oxidase is characterized as a multicomponent enzyme which is activated to produce superoxide anion. NCF2, NCF1, and a membrane bound cytochrome b558 are required for the activation of the latent NADPH oxidase. The human NCF1 gene encodes a 390 amino acids protein without a signal peptide. The NCF1 gene interacts with other subunits of nicotinamide adenine dinucleotide phosphate-oxidase (NADPH) and ...
TMPY-02464	Catalase/CAT Protein, Human, Recombinant (His) catalase	Human	Baculovirus Insect Cells
	Catalase is a ubiquitously expressed enzyme that catalyzes the decomposition of hydrogen peroxide to water and oxygen. It is a tetramer of four polypeptides chains containing four porphyrin heme groups that allow the enzyme to react with the hydrogen peroxide. The optimum PH of human catalase is approximately 7 and the optimum temperature is at 37 degree. Both the PH optimum and temperature for other catalases varies depending on the species. Catalase can be inhibited by a flux of O2-generated i...
TMPY-04122	ATOX1 Protein, Human, Recombinant (His) HAH1,ATX1,antioxidant 1 copper chaperone	Human	E. coli
	ATOX1 is a cytoplasmic copper chaperone that interacts with the copper-binding domain of the membrane copper transporters ATP7A and ATP7B. ATOX1 has also been suggested to have a potential anti-oxidant activity. As the trace element copper is essential, but extremely toxic in high concentrations, intracellular copper concentrations are tightly controlled. Once in the cell, copper is distributed by metallochaperones, including the small cytoplasmic protein ATOX1. ATOX1 plays an important role in ...
TMPH-01502	Humanin Protein, Human, Recombinant (GST) Humanin,Humanin mitochondrial,MT-RNR2	Human	E. coli
	Plays a role as a neuroprotective factor. Protects against neuronal cell death induced by multiple different familial Alzheimer disease genes and amyloid-beta proteins in Alzheimer disease. Mediates its neuroprotective effect by interacting with a receptor complex composed of IL6ST/GP130, IL27RA/WSX1 and CNTFR. Also acts as a ligand for G-protein coupled receptors FPR2/FPRL1 and FPR3/FPRL2. Inhibits amyloid-beta protein 40 fibril formation. Also inhibits amyloid-beta protein 42 fibril formation....
TMPH-01503	Humanin Protein, Human, Recombinant (hFc) MT-RNR2,Humanin,Humanin mitochondrial	Human	HEK293 Cells
	Plays a role as a neuroprotective factor. Protects against neuronal cell death induced by multiple different familial Alzheimer disease genes and amyloid-beta proteins in Alzheimer disease. Mediates its neuroprotective effect by interacting with a receptor complex composed of IL6ST/GP130, IL27RA/WSX1 and CNTFR. Also acts as a ligand for G-protein coupled receptors FPR2/FPRL1 and FPR3/FPRL2. Inhibits amyloid-beta protein 40 fibril formation. Also inhibits amyloid-beta protein 42 fibril formation....

重组蛋白

Superoxide dismutase [Fe] Protein, Anabaena sp., Recombinant (His & KSI)

Cat.No: TMPH-00052

Species: Anabaena

Expression System: E. coli

SOD1 Protein, Danio rerio, Recombinant (His & Myc & SUMO)

Cat.No: TMPH-00469

Species: Danio rerio (Zebrafish)

Expression System: E. coli

SOD2 Protein, Human, Recombinant (His)

Cat.No: TMPJ-00105

Species: Human

Expression System: HEK293 Cells

SOD2 Protein, Human, Recombinant (E. coli, His)

Cat.No: TMPJ-00104

Species: Human

Expression System: E. coli

SOD2 Protein, Human, Recombinant

Cat.No: TMPY-02044

Species: Human

Expression System: E. coli

SOD1 Protein, Mouse, Recombinant (His)

Cat.No: TMPH-02918

Species: Mouse

Expression System: P. pastoris (Yeast)

SOD1 Protein, Rat, Recombinant (His)

Cat.No: TMPH-03378

Species: Rat

Expression System: P. pastoris (Yeast)

SodC Protein, Mycobacterium tuberculosis, Recombinant (His & Myc)

Cat.No: TMPH-03612

Species: Mycobacterium tuberculosis

Expression System: E. coli

SOD1 Protein, Mouse, Recombinant (E. coli, His)

Cat.No: TMPH-02917

Species: Mouse

Expression System: E. coli

SOD3 Protein, Human, Recombinant

Cat.No: TMPH-01318

Species: Human

Expression System: E. coli

SOD3 Protein, Human, Recombinant (His)

Cat.No: TMPH-01317

Species: Human

Expression System: E. coli

SOD1 Protein, Human, Recombinant (His)

Cat.No: TMPY-01585

Species: Human

Expression System: E. coli

NOX4 Protein, Human, Recombinant (E. coli, His)

Cat.No: TMPH-01746

Species: Human

Expression System: E. coli

NOX4 Protein, Human, Recombinant (Cell-Free, His)

Cat.No: TMPH-01745

Species: Human

Expression System: E. coli

NOX1 Protein, Human, Recombinant (His)

Cat.No: TMPH-01744

Species: Human

Expression System: E. coli

PON3 Protein, Human, Recombinant (S50N, His)

Cat.No: TMPY-02686

Species: Human

Expression System: Baculovirus Insect Cells

CYBB Protein, Human, Recombinant (His)

Cat.No: TMPH-03751

Species: Human

Expression System: E. coli

PRG3 Protein, Human, Recombinant (His)

Cat.No: TMPJ-00582

Species: Human

Expression System: HEK293 Cells

C5AR1 Protein, Human, Recombinant (Cell-Free, His)

Cat.No: TMPH-01023

Species: Human

Expression System: E. coli

C5AR1 Protein-VLP, Human, Recombinant (His)

Cat.No: TMPH-01022

Species: Human

Expression System: HEK293 Cells

FPR1 Protein, Human, Recombinant (GST & His & Myc)

Cat.No: TMPH-01346

Species: Human

Expression System: E. coli

FPR1 Protein, Mouse, Recombinant (GST & His & Myc)

Cat.No: TMPH-02658

Species: Mouse

Expression System: E. coli

Dps Protein, Helicobacter pylori, Recombinant (His & SUMO)

Cat.No: TMPH-00794

Species: Helicobacter pylori

Expression System: E. coli

NCF1 Protein, Human, Recombinant (His)

Cat.No: TMPJ-00848

Species: Human

Expression System: E. coli

Catalase/CAT Protein, Human, Recombinant (His)

Cat.No: TMPY-02464

Species: Human

Expression System: Baculovirus Insect Cells

ATOX1 Protein, Human, Recombinant (His)

Cat.No: TMPY-04122

Species: Human

Expression System: E. coli

Humanin Protein, Human, Recombinant (GST)

Cat.No: TMPH-01502

Species: Human

Expression System: E. coli

Humanin Protein, Human, Recombinant (hFc)

Cat.No: TMPH-01503

Species: Human

Expression System: HEK293 Cells

Cat. No.	Product Name	Target	Signaling Pathways
T71306	Gemfibrozil-d6
	Gemfibrozil-d6 is intended for use as an internal standard for the quantification of gemfibrozil by GC- or LC-MS. Gemfibrozil is a peroxisome proliferator-activated reporter α and PPARγ agonist. In vivo, gemfibrozil reduces serum total cholesterol, triglyceride, and LDL levels in a rat model of high-cholesterol diet-induced hyperlipidemia. Gemfibrozil reduces atherosclerotic plaque area, superoxide production, and expression of the genes encoding the NF-κB subunit p65 and chemokine (C-C) motif l...
TMIJ-0434	p-Benzoquinone-d4
	p-Benzoquinone-d4 是 p-Benzoquinone 的氘代化合物。p-Benzoquinone 的 CAS 号为 106-51-4。p-Benzoquinone 是一种超氧化物清除剂。它是一种在人体血液中发现的有毒代谢物。
T35778	Ochratoxin A-13C20 Ochratoxin A-13C20
	Ochratoxin A-13C20is intended for use as an internal standard for the quantification of ochratoxin A by GC- or LC-MS. Ochratoxin A is a mycotoxin that has been found inAspergillusandPenicillium.1It increases lipid peroxide levels and the number of apoptotic cells, as well as reduces superoxide dismutase activity in rat kidney when administered at a dose of 120 μg/kg.2Topical application of ochratoxin A (80 μg/mouse) induces DNA damage, cell cycle arrest at the G0/G1phase, and apoptosis in mouse ...
T70313	Indoxyl Sulfate-d5 potassium salt
	Indoxyl sulfate-d5 is intended for use as an internal standard for the quantification of indoxyl sulfate by GC- or LC-MS. Indoxyl sulfate is a uremic toxin and a metabolite of tryptophan. It is formed via sulfation of indole, an intermediate generated from tryptophan by intestinal bacteria, by the sulfotransferase (SULT) isoform 1A1 variant 2 (SULT1A1*2) in the liver. Indoxyl sulfate activates the aryl hydrocarbon receptor (AhR) in HepG2 40/6 hepatoma cells (EC50 = 12.1 nM in a reporter assay). ...

同位素标记化合物

Cat.No: T71306

p-Benzoquinone-d4

Cat.No: TMIJ-0434

Ochratoxin A-13C20

Cat.No: T35778

Synonym: Ochratoxin A-13C20

Indoxyl Sulfate-d5 potassium salt

Cat.No: T70313

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