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Search Results for " sorbitol "

Targets Recommended: Others

8

抑制剂 & 化合物

7

天然产物

4

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T20256	Sorbitol, L- L-Glucitol	Others	Others
	Sorbitol, L- is a sugar alcohol. It can be obtained by the reduction of glucose, which changes the aldehyde group to a hydroxyl group. It is converted to fructose by sorbitol-6-phosphate 2-dehydrogenase. Sorbitol is an isomer of mannitol, another sugar al
T32193	Iron sorbitex Jectofer,Yectofer,Iron Sorbitol,HSDB 1967,Astra 1572	Others	Others
	Iron Sorbitex is used for the treatment of Iron Sorbitex deficiency anemia in patients with chronic kidney disease. Iron Sorbitex can be used as an Iron Sorbitex replacement product used for the treatment of Iron Sorbitex deficiency anemia in patients wit
T2013	Ponalrestat	Reductase	Endocrinology/Hormones; Metabolism
	Ponalrestat 是一种口服有效的，选择性的和非竞争性的醛糖还原酶抑制剂，对 ALR2选择性选择性较高，Ki 为 7.7 nM，对 ALR1 的选择性较弱，Ki 为 60 μM。Ponalrestat 抑制葡萄糖向山梨糖醇的转化。
T0503	Meglumine Meglumin,Methylglucamin,葡甲胺,葡萄糖甲胺,Methylglucamine	Others	Others
	Meglumine (Meglumin) 是一种氨基糖，来源于山梨糖醇。其中常在药物中用作赋形剂，并与碘代化合物葡甲胺和碘帕胺葡甲胺等造影剂中的碘化化合物一起使用。
T9527	Span-85 Sorbitan trioleate,司盘85	Others	Others
	Span-85 (Sorbitan trioleate) 是一种合成的非离子乳化剂，由山梨糖醇或山梨糖醇与食品级棕榈酸部分酯化而成。粘度低，HLB 值最小，亲油性最强。它是一种优良的油包水（w/O）乳化剂和 O/w 型辅助乳化剂。
T20767	Sorbitan monostearate Span 55,Emsorb 2505,Sorbon S 60,Liposorb S-20,Sorgen 50	Others	Others
	Sorbitan monostearate is an ester of stearic acid and sorbitan (a sorbitol derivative), it is also sometimes referred to as a synthetic wax.
T31070	CP-642931 CP 642931,UNII-4Q45INJ6TQ	Others	Others
	Cp-642931 is an effective and specific sorbitol dehydrogenase inhibitor (SDI).
T78702	PTP1B/AKR1B1-IN-1	Phosphatase	Metabolism
	PTP1B/AKR1B1-IN-1是一种针对PTP1B和AKR1B1的双重抑制剂，其IC50值分别为0.06 μM和4.3 μM。该化合物也能抑制TC-PTP，IC50为9 μM。在小鼠成肌细胞中，PTP1B/AKR1B1-IN-1作为胰岛素模拟剂使用，并能减少AKR1B1依赖的山梨醇积累，有助于抑制2型糖尿病的发展并控制血糖水平。

化合物

Cat.No: T20256

Synonym: L-Glucitol

Target: Others

Cat.No: T32193

Synonym: Jectofer,Yectofer,Iron Sorbitol,HSDB 1967,Astra 1572

Target: Others

Cat.No: T2013

Target: Reductase

Cat.No: T0503

Synonym: Meglumin,Methylglucamin,葡甲胺,葡萄糖甲胺,Methylglucamine

Target: Others

Cat.No: T9527

Synonym: Sorbitan trioleate,司盘85

Target: Others

Sorbitan monostearate

Cat.No: T20767

Synonym: Span 55,Emsorb 2505,Sorbon S 60,Liposorb S-20,Sorgen 50

Target: Others

Cat.No: T31070

Synonym: CP 642931,UNII-4Q45INJ6TQ

Target: Others

PTP1B/AKR1B1-IN-1

Cat.No: T78702

Target: Phosphatase

Cat. No.	Product Name	Target	Signaling Pathways
T0332	D-Sorbitol 山梨醇,Glucitol,Sorbitol,D-Glucitol	Others; Endogenous Metabolite	Metabolism; Others
	D-Sorbitol (Sorbitol) 是一种六碳糖醇，能够用作糖的替代品。D-Sorbitol 能够用作稳定的赋形剂和/或等渗剂，保湿剂，增稠剂，甜味剂和膳食补充剂。
T0585	Maltitol 麦芽糖醇,4-O-α-glucopyranosyl-D-sorbitol,Maltisorb	Others	Others
	Maltitol (4-O-α-glucopyranosyl-D-sorbitol) 是糖醇，它具有蔗糖 75-90% 的甜度，可用作糖的替代品。它也可用作明胶胶囊中的增塑剂，润肤剂和保湿剂。
TQ0195	1,5-Anhydrosorbitol	Others; Endogenous Metabolite	Metabolism; Others
	1,5-Anhydrosorbitol 是评价短期血糖控制情况的可靠指标，主要来源于食物。
T7964	Isomalt 异麦芽酮糖醇,Palatinitol,Palatinit	Others; Dehydrogenase	Metabolism; Others
	Isomalt (Palatinitol) 是无毒的、具有良好耐受性的多元醇和蛋白质稳定的赋形剂，在冷冻干燥过程中可适度稳定乳酸脱氢酶(LDH)，并在储存期间表现更好。它传统上在食品工业中用作甜味剂，也在制药中用作压片赋形剂。
T0414	D-Mannitol Mannite,Mannitol,D-甘露糖醇,Osmitrol	Apoptosis; Dehydrogenase; Endogenous Metabolite	Apoptosis; Metabolism
	D-Mannitol (Mannitol) 是与山梨醇相关的利尿剂和肾脏诊断辅助剂，具有较弱的肾脏血管扩张活性。
T5S1988	Isorhamnetin-3-O-glucoside Isorhamnetin-3-O-beta-D-Glucoside,异鼠李素-3-O-葡萄糖苷	Others	Others
	Isorhamnetin-3-O-glucoside (Isorhamnetin-3-O-beta-D-Glucoside) 是一种天然化合物，广泛存在于蔬菜和水稻中，经消化后可在肠道菌群中代谢。
TN2201	Semilicoisoflavone B	Others	Others
	Semilicoisoflavone B can inhibit sorbitol formation of rat lens incubated with a high concentration of glucose, indicates that it may be effective for preventing osmotic stress in hyperglycemia.

天然产物

Cat.No: T0332

Synonym: 山梨醇,Glucitol,Sorbitol,D-Glucitol

Target: Others, Endogenous Metabolite

Cat.No: T0585

Synonym: 麦芽糖醇,4-O-α-glucopyranosyl-D-sorbitol,Maltisorb

Target: Others

1,5-Anhydrosorbitol

Cat.No: TQ0195

Target: Others, Endogenous Metabolite

Cat.No: T7964

Synonym: 异麦芽酮糖醇,Palatinitol,Palatinit

Target: Others, Dehydrogenase

Cat.No: T0414

Synonym: Mannite,Mannitol,D-甘露糖醇,Osmitrol

Target: Apoptosis, Dehydrogenase, Endogenous Metabolite

Isorhamnetin-3-O-glucoside

Cat.No: T5S1988

Synonym: Isorhamnetin-3-O-beta-D-Glucoside,异鼠李素-3-O-葡萄糖苷

Target: Others

Semilicoisoflavone B

Cat.No: TN2201

Target: Others

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPJ-00524	SORD Protein, Human, Recombinant (His) Sorbitol Dehydrogenase,L-Iditol 2-Dehydrogenase,SOR...	Human	HEK293 Cells
	Sorbitol dehydrogenase, also known as L-iditol 2-dehydrogenase and SORD, is a member of the zinc-containing alcohol dehydrogenase family. SORD exsits in a homotetramer and binds one zinc ion per subunit. SORD is expressed in kidney and epithelial cells of both benign and malignant prostate tissue. SORD can converts sorbitol to fructose and catalyzes the interconversion of polyols and their corresponding ketoses, and together with aldose reductase to make up the sorbitol pathway. SORD is up-regul...
TMPY-02438	AKR1B1 Protein, Human, Recombinant (His) ALDR1,AR,ADR,aldo-keto reductase family 1, member B1 (aldose...	Human	E. coli
	Aldose reductase (AKR1B1) belongs to the aldo/keto reductase superfamily. AKR1B1 is a NADPH-dependent aldo-keto reductase best known as the rate-limiting enzyme of the polyol pathway. Expression of AKR1B1 was the highest in lens and retina. It is the first enzyme in the polyol pathway through which glucose is converted to sorbitol which is important for the function of various organs in the body, and has been implicated in the etiology of diabetic complications. AKR1B1 is quite abundant in the c...
TMPY-02461	AKR1A1 Protein, Human, Recombinant (His) DD3,ALDR1,HEL-S-6,aldo-keto reductase family 1, member A1 (a...	Human	E. coli
	Aldehyde reductase (AKR1A1) is a member of the aldo-keto reductase superfamily, which consists of more than 40 known enzymes and proteins that includes variety of monomeric NADPH-dependent oxidoreductases, such as aldehyde reductase. Aldehyde reductase has wide substrate specificities for carbonyl compounds. These enzymes are implicated in the development of diabetic complications by catalyzing the reduction of glucose to sorbitol. Aldehyde reductase possess a structure with a beta-alpha-beta fo...
TMPY-04460	OXSR1 Protein, Human, Recombinant (GST) OSR1,oxidative stress responsive 1	Human	Baculovirus Insect Cells
	Oxidative stress-responsive 1 protein (OXSR1), also known as Serine/threonine-protein kinase OSR1, is a member of the Ser/Thr protein kinase family of proteins. OXSR1 regulates downstream kinases in response to environmental stress, and may play a role in regulating the actin cytoskeleton. OXSR1 is a 58 kDa protein of 527 amino acids that is widely expressed in mammalian tissues and cell lines. The amino acid (aa) sequence of the predicted OXSR1 protein is 39% identical to that of human SOK1. Of...

重组蛋白

SORD Protein, Human, Recombinant (His)

Cat.No: TMPJ-00524

Species: Human

Expression System: HEK293 Cells

AKR1B1 Protein, Human, Recombinant (His)

Cat.No: TMPY-02438

Species: Human

Expression System: E. coli

AKR1A1 Protein, Human, Recombinant (His)

Cat.No: TMPY-02461

Species: Human

Expression System: E. coli

OXSR1 Protein, Human, Recombinant (GST)

Cat.No: TMPY-04460

Species: Human

Expression System: Baculovirus Insect Cells

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