97
57
3
37
5
Cat. No. | Product Name | ||
---|---|---|---|
L6001 | Mini真菌代谢天然产物筛选库 | Inquiry | |
L2610 | 神经递质受体化合物库 | 1513 compounds | |
1513 种与神经递质受体相关的化合物,用于高通量、高内涵筛选; | |||
L6120 | 黄酮类天然产物库 | 514 compounds | |
514 种黄酮类天然产物的独特集合,可用于高通量筛选和高内涵筛选; |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
TD0101 |
AQC
6-Aminoquinolyl-N-hydroxysccinimidyl carbamate |
Others | Others |
AQC (6-Aminoquinolyl-N-hydroxysccinimidyl carbamate) 是一种高效液相色谱荧光检测氨基酸或蛋白质序列的试剂。它能够与一级和二级氨基酸反应生成荧光衍生物,在皮摩尔水平下能够检测氨基酸。 | |||
TP2333 |
cyclo(L-Pro-L-Tyr)
|
Others | Others |
cyclo(L-Pro-L-Tyr) 是真菌和细菌的次生代谢产物。 | |||
T29067 |
Upacicalcet
PLS-240,SK-1403,AJT-240 |
Calcium Channel | Membrane transporter/Ion channel; Metabolism |
Upacicalcet (AJT-240) 是一种静脉内拟钙剂,是一种可用于人血液透析的 SHPT, 通过直接作用于甲状旁腺细胞膜钙敏感受体来抑制过量的甲状旁腺激素 (PTH) 分泌,从而降低血液中的 PTH 水平。 3 Upacicalcet 是钙敏感受体的正变构调节剂,可预防大鼠腺嘌呤诱导的继发性甲状旁腺功能亢进模型中的血管钙化和骨骼疾病。 | |||
T32155 |
Indecainide
Ricainide,Ricainid,Decabid,Indecainidum,Indecainida |
Others | Others |
Indecainide (Ricainid) 是一种新型抗心律失常化合物,具有致癌性,可用于研究继发于冠状动脉疾病或心肌病的慢性稳定型室性心律失常。 | |||
T6112 |
Doxercalciferol
TSA 840,度骨化醇,Hectorol,1.alpha.-Hydroxyvitamin D2,1α-hydroxyvitamin D2 |
Others | Others |
Doxercalciferol (TSA 840) 是一种维生素 D2 类似物,是一种维生素 D 受体激活剂,能够阻碍肾病的进程。 | |||
T0384 |
Estradiol benzoate
Benzoestrofol,Benzhormovarine,苯甲酸雌二醇,Benovocylin |
Estrogen Receptor/ERR; Estrogen/progestogen Receptor | Endocrinology/Hormones |
Estradiol benzoate (Benzhormovarine) 是一种类固醇性激素,是一种雌二醇的前体药物。它表现出轻微的合成代谢特性,增加血液凝固性。 | |||
T16239 |
N-Methylisatoic anhydride
NMIA,N-甲基靛红酸酐,1-甲基苯唑 |
Others | Others |
N-Methylisatoic anhydride 是一种 RNA 的 2'-OH 选择性酰化剂,常用于使用 SHAPE(通过引物延伸分析的选择性2'-OH 酰化)技术解析二级 RNA 结构。 | |||
TQ0200 |
Paricalcitol
|
Others | Others |
Paricalcitol 是一种 vitamin D receptor 激活剂,是一种 vitamin D 类似物,用于研究继发性甲状旁腺功能亢进,该疾病与慢性肾功能衰竭有关。 | |||
T74041 |
GDP-L-fucose
|
Endogenous Metabolite | Metabolism |
GDP-L-fucose 是一种广泛存在与真菌和植物中的核苷酸糖,参与从头代谢途径和次要的补救代谢途径。 | |||
T18895 |
5(6)-FAM SE
5(6)-羧基荧光素琥珀酰亚胺酯,5(6)-Carboxyfluorescein N-hydroxysuccinimide ester |
Others | Others |
5(6)-FAM SE (5(6)-Carboxyfluorescein N-hydroxysuccinimide ester) 是绿色荧光染料,普遍用于标记蛋白质。 | |||
T72042 |
Acetylsulfamerazine
N-Acetylsulfamerazine |
Others | Others |
Acetylsulfamerazine (N-Acetylsulfamerazine) 是磺胺甲基嗪的次级代谢产物,对纤维素消化和瘤胃内分泌的活性有轻微的抑制作用,具有抗微生物活性。 | |||
TP1236 |
Etelcalcetide hydrochloride
AMG 416 hydrochloride,维考西肽盐酸盐,KAI-4169 hydrochloride |
CaSR | GPCR/G Protein |
Etelcalcetide hydrochloride (AMG 416 hydrochloride) 是具有有钙敏感受体 (CaSR) 活化剂作用的合成肽,能够减少接受血液透析的继发性甲状旁腺功能亢进患者的甲状旁腺激素 (PTH) 浓度。 | |||
TP1186 |
Cyclo(Phe-Pro)
六氢-3-(苯基甲基)吡咯并[1,2-A]吡嗪-1,4-二酮,A-64863,Cyclo(phenylalanylprolyl) |
Others | Others |
Cyclo(Phe-Pro) (A-64863) 是创伤弧菌的群体感应分子,能够与 RIG-I 的特异性相互作用,阻碍 RIG-I 的多泛素化,并抑制 IRF-3 的激活和 I 型干扰素的产生。它提高 HCV 和流感病毒的易感性。 | |||
T64340 |
ML267
4-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)-N-(4-methoxypyridin-2-yl)piperazine-1-carbothioamide trifluoroacetate |
Others | Others |
ML267 (4-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)-N-(4-methoxypyridin-2-yl)piperazine-1-carbothioamide trifluoroacetate) 是一种有效的细菌磷酸泛酰氨基转移酶抑制剂,可减弱二次代谢并阻碍细菌生长。 | |||
T22346 |
Indomethacin sodium hydrate
Indometacin sodium hydrate |
COX | Immunology/Inflammation; Neuroscience |
Indomethacin sodium hydrate (Indometacin sodium hydrate) 是一种口服活性、竞争性和可逆性的 COX1/2 抑制剂,具有潜在的抗炎活性,可诱发的偏头痛,诱导的胃肠道损伤,可用于研究成人继发于严重创伤性脑损伤的颅内压增高和类风湿性关节。 | |||
T64334 |
Glycolithocholic acid, sodium salt
|
Others | Others |
Glycolithocholic acid, sodium salt 是 Glycolithocholic acid 的钠盐。Glycolithocholic acid 是一种甘氨酸结合的次级胆汁酸。Glycolithocholic acid 可用于诊断溃疡性结肠炎 (UC),非酒精性脂肪性肝炎 (NASH0) 和原发性硬化性胆管炎 (PSC)。 | |||
T19450 |
N-desmethyl Enzalutamide
4-[3-[4-氰基-3-(三氟甲基)苯基]-5,5-二甲基-4-氧代-2-硫代-1-咪唑烷基]-2-氟苯甲酰胺,N-desmethyl MDV 3100 |
Androgen Receptor | Endocrinology/Hormones |
N-desmethyl Enzalutamide (N-desmethyl MDV 3100) 是一种 Enzalutamide 的主要活性代谢物,具有与 Enzalutamide 相似的一级和二级药效功效,并在与 Enzalutamide 大致相同的血浆浓度下循环。 | |||
T27527 |
HBF-0259
HBF 0259 |
Antiviral | Immunology/Inflammation |
HBF-0259 是有效的乙型肝炎病毒 表面抗原分泌选择性抑制剂,在 HepG2.2.15 细胞中的 EC50为 1.5 μM。 | |||
T5848 |
Biocytin
|
Endogenous Metabolite | Metabolism |
Biocytin 是一种 D-生物素和 L-赖氨酸的共轭物,D-生物素的羧酸盐通过仲酰胺键与L-赖氨酸的 α-胺偶联。它是神经解剖学示踪剂,通常用于绘制大脑的连接性。它在顺逆行和细胞内神经解剖学研究以及生物素酶测定中用作通用标记物。 | |||
T0991 |
Desipramine hydrochloride
NSC-114901,Desmethylimipramine,盐酸去甲咪嗪,JB-8181,EX-4355,Norimipramine,G-35020 |
Dopamine Receptor; 5-HT Receptor; Serotonin Transporter; Adrenergic Receptor | GPCR/G Protein; Neuroscience |
Desipramine hydrochloride (Norimipramine) 是一种二苯并氮杂类衍生物三环类抗抑郁药,可作为选择性去甲肾上腺素再摄取抑制剂。 它还显示出较弱的 5-羟色胺再摄取抑制、α1 阻断、抗组胺和抗胆碱能作用。 | |||
T72077 |
Imidacloprid-urea
|
Others | Others |
Imidacloprid-urea 是吡虫啉的次级代谢产物。吡虫啉是一种有效且广泛使用的新烟碱类化合物,对谷物,蔬菜,茶叶和棉花的害虫具有抑制作用。Imidacloprid-urea 可以占据或阻断吡虫啉在土壤上的吸附位点,从而可能影响吡虫啉在环境中的去向、转运和生物利用度。 | |||
T29067L |
Upacicalcet HCl
Upacicalcet HCl(1333218-50-0 Free base) |
CaSR | GPCR/G Protein |
Upacicalcet HCl 是一种静脉内拟钙剂,通过直接作用于甲状旁腺细胞膜钙敏感受体来抑制过量的甲状旁腺激素 (PTH) 分泌,从而降低血液中的 PTH 水平。Upacicalcet HCl 可用于治疗血液是一种新型继发性甲状旁腺功能亢进化合物,靶向钙敏感受体的氨基酸结合位点。 | |||
T19722 |
Benazeprilat
CGS14831,CGS-14831,CGS 14831 |
RAAS; Endogenous Metabolite | Endocrinology/Hormones; Metabolism |
Benazeprilat(CGS 14831) 是一种具有口服活性的贝那普利活性代谢物。Benazeprilat 具有高效的抗血压活性,可与其他其他类别的化合物(包括噻嗪类利尿剂和钙通道阻滞剂)联合使用来减少与心血管风险和继发性终末器官损伤相关的疾病的发生。Benazeprilat 可能用于研究急性左心室衰竭。 | |||
T71703L |
Isomer-Turosteride
Isomer-Turosteride(Isomer-137099-09-3) |
Reductase | Endocrinology/Hormones; Metabolism |
Isomer-Turosteride (Isomer-Turosteride(Isomer-137099-09-3)) 是一种新型 5α- 还原酶抑制剂。Isomer-Turosteride 在成年大鼠中的抗前列腺作用与抑制T向 DHT 的转化有关。Isomer-Turosteride引起前列腺 DHT 的降低,与 T 含量的继发性增加无关。Isomer-Turosteride 具有抗癌活性,可抑制肿瘤细胞的生长。 | |||
T41163 |
ZNL 02-096
Pomalidomide-C3-adavosertib |
Apoptosis; Wee1 | Apoptosis; Cell Cycle/Checkpoint |
ZNL 02-096 (Pomalidomide-C3-adavosertib) 是一种快速和选择性的 Wee1 降解剂 (IC50=3.58 nM)。ZNL 02-096 可在亚摩尔浓度下选择性降解 Wee1,而不损伤 AZD 1775 的二级靶点 PLK1。在体外 MOLT-4 细胞中,ZNL 02-096 可诱导 Wee1 降解、DNA 损伤积累、细胞周期停滞在 G2/M 期和细胞凋亡。ZNL 02-096 在 300 种癌症细胞系中显示出抗增殖作用。 | |||
T16353 |
Meseclazone
美西拉宗,W2395,NSC297623 |
AChR | Neuroscience |
Meseclazone has anti-inflammatory, analgesic, and antipyretic activity. Meseclazone shows inhibitory potency of secondary phase ADP aggregation. | |||
T1341L |
Nortropine Hydrochloride
|
Others | Others |
Nortropine Hydrochloride is a secondary metabolite of tropine derivative drugs. | |||
T32952 |
Lunacalcipol
|
Others | Others |
Lunacalcipol is used for the treatment of Secondary Hyperparathyroidism. | |||
T32871 |
Lopinavir M-3/M-4
Lopinavir Metabolite M-3/M-4 |
Others | Others |
Lopinavir M-3/M-4 is a Lopinavir secondary metabolite. | |||
T34934 |
Trichovirin I IB
Harzianin HC I |
Others | Others |
Trichovirin I IB is a peptaibiotic, alpha-aminobutyric acid-rich secondary metabolite of fungi. | |||
T31441 |
Dienone B
NSC289074,NSC-289074,NSC 289074 |
Others | Others |
Dienone B is a cytotoxic secondary metabolite from tyrosine as isolated from the sponges Verongia aerophoba & Aplysina aerophoba. | |||
T27526 |
Halenaquinone
|
Others | Others |
Halenaquinone is a phosphatidylinositol 3-kinase inhibitor. Halenaquinone specifically inhibits the secondary DNA binding of RAD51. Halenaquinone inhibits RANKL-induced osteoclastogenesis. Halenaquinone induces apoptosis in PC12 cells. | |||
T11986 |
Mebeverine acid
Mebeverine metabolite Mebeverine acid,美贝维林酸 |
Drug Metabolite | Metabolism |
Mebeverine acid (Mebeverine metabolite Mebeverine acid) 是美贝维林的次级代谢产物,可用作口服美贝维林的标志物。 | |||
T26595 |
Allosamidin
A-82516,A 82516,A82516 |
Others | Others |
Allosamidin, a chitinase inhibitor and typical secondary metabolite of Streptomyces, may be used as a pesticide and anti-asthmatic agent. | |||
T69376 |
Viriditoxin
|
Others | Others |
Viriditoxin is a secondary metabolite isolated from Aspergillus viridinutans that has been shown to inhibit FtsZ, the bacterial homologue of eukaryotic tubulin. | |||
T26596 |
Allylpyrocatechol
|
Others | Others |
Allylpyrocatechol is an antioxidant. Allylpyrocatechol attenuates collagen-induced arthritis via attenuation of oxidative stress secondary to modulation of the MAPK, JAK/STAT, and Nrf2/HO-1 pathways. | |||
T40736 |
Doxorubicinol hydrochloride
13-Dihydroadriamycin hydrochloride |
Others | Others |
Doxorubicinol hydrochloride, also known as 13-Dihydroadriamycin hydrochloride, is a secondary alcohol metabolite derived from Doxorubicin. | |||
T27825 |
LG190178
LG-190178,LG 190178 |
Others | Others |
LG190178, a vitamin D receptor (VDR) ligand, is a therapeutic agent used for the treatment of psoriasis, osteoporosis, and secondary hyperparathyroidism. | |||
T30827 |
Cgp 33304
Cgp-33304,Cgp33304 |
Others | Others |
CGP 33304 is a dual leukotriene receptor antagonist and phospholipase A2 inhibitor. It prevents hypoxia secondary to bronchial constriction induced by leukotriene in a shocking state. | |||
T2968L |
Hyodeoxycholic acid sodium salt
Sodium hyodeoxycholate,HDCA sodium |
Others | Others |
Hyodeoxycholic acid sodium salt is a natural secondary bile acid. It improves high-density lipoprotein function, reduces farnesoid X receptor antagonist bile acids, and induces strong cytotoxicity, apoptosis, and IL-8 synthesis. | |||
T26200 |
Somatostatin RC 102
Somatostatin RC102,Somatostatin-RC-102,Somatostatin RC-102 |
Others | Others |
Somatostatin RC 102 is a peptide hormone. It regulates the endocrine system and affects neurotransmission and cell proliferation via interaction with G protein-coupled somatostatin receptors and inhibition of the release of numerous secondary hormones. | |||
T39162 |
1,1,1,3-Tetrachloroacetone
|
Others | Others |
1,1,1,3-Tetrachloroacetone, a halogenated compound, is known to form ozone-chlorine and ozone-chloramine disinfection byproducts (DBPs) when elevated bromide levels are present in water treated with chlorine or chloramine as secondary disinfectants. | |||
T40725 |
1,3-Dibromo-1,3-dichloroacetone
|
Others | Others |
1,3-Dibromo-1,3-dichloroacetone is a chemical compound that acts as a disinfection byproduct (DBP) of halogenated ozone-chlorine and ozone-chloramine, particularly at heightened bromide concentrations, when used as secondary disinfectants. | |||
T39052 |
1,1-Dibromo-3-chloroacetone
|
Others | Others |
1,1-Dibromo-3-chloroacetone is an ozone-chlorine and ozone-chloramine disinfection byproduct (DBP) which is halogenated. It is formed at high bromide levels when chlorine or chloramine is utilized as a secondary disinfectant. | |||
T28015 |
Mequitamium iodide
LG-30435,LG 30435,LG30435 |
Others | Others |
Mequitamium iodide is a platelet activating factor (PAF) inhibitor. Mequitamium inhibits PAF-acether induced platelet aggregation and bronchoconstriction. Mequitamium is capable of inhibiting platelet-mediated effects of PAF by interfering with secondary | |||
T40838 |
20-O-Demethyl-AP3
20-O-Demethyl-AP3 |
Others | Others |
20-O-Demethyl-AP3 is a secondary metabolite derived from Ansamitocin P-3, and Ansamitocin P-3 is a macrocyclic antitumor antibiotic exerting its therapeutic effects by inhibiting microtubules. | |||
T74465 |
Colibactin
|
||
Colibactin 是一种复杂的次级代谢产物,由一些具有遗传毒性的肠道大肠杆菌菌株产生。Colibactin 具有研究结直肠癌的潜力。 | |||
T39444 |
Upacicalcet sodium
|
Others | Others |
Upacicalcet (sodium) is an intravenous calcimimetic agent that acts directly on parathyroid cell membrane calcium-sensing receptors to suppress excessive parathyroid hormone (PTH) secretion, thereby lowering blood PTH levels. It is indicated for the research of secondary hyperparathyroidism (SHPT). | |||
T37623 |
1,2-Dierucoyl-sn-glycero-3-PC
|
Others | Others |
1,2-Dierucoyl-sn-glycero-3-PC is a phospholipid containing erucic acid at the sn-1 and sn-2 positions. It has been used in the study of lipid membranes and to determine the effect of long-chain phospholipids on the secondary structure of human islet amyloid polypeptide (hIAPP). | |||
T15113 |
Diazepinomicin
TLN-4601,BU 4664L,ECO-4601 |
Others | Others |
Diazepinomicin is a secondary metabolite produced by Micromonospora sp. It inhibits the EGF-induced Ras-ERK MAPK signaling pathway and induces apoptosis. Diazepinomicin also is an anti-tumor agent for K-Ras mutant models. |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T19606 |
Xylan
|
Others | Others |
Xylan 是开花植物的次生植物细胞壁中的半纤维素成分,是一种由木糖单元组成的多糖,主要包含由纤维素连接的 β-D-木糖单位。 | |||
T2731 |
Usnic Acid
Usniacin,松萝酸,地衣酸 |
Antibacterial; Autophagy | Autophagy; Microbiology/Virology |
Usnic Acid (Usniacin) 是地衣次生代谢产物,具有独特的二苯并呋喃骨架。它是一种抗菌剂、抗肿瘤剂和酶抑制剂。 | |||
T5595 |
Tropine
3alpha-Tropanol,托品醇,Pseudotropine |
Others | Others |
Tropine 是一种茄科植物的次生代谢产物,是抗胆碱能试剂。它是一种常见的用于合成各种生物活性生物碱(如 hyoscyamine、scopolamine)的中间体。 | |||
TN1413 |
Atranorin
荔枝素,巴美灵,荔枝素 |
Endogenous Metabolite; NO Synthase; Ras | GPCR/G Protein; Immunology/Inflammation; MAPK; Metabolism |
Atranorin 是地衣的次生代谢产物,具有显着的抗伤害、抗炎和氧化还原活性,对 H(2)O(2) 诱导的氧化应激下的细胞具有细胞保护作用。 | |||
T0700 |
Ursodeoxycholic acid
熊去氧胆酸,UDCA,Ursodiol |
Potassium Channel; Endogenous Metabolite | Membrane transporter/Ion channel; Metabolism |
Ursodeoxycholic acid (UDCA)是一种有效的肝脏特异性脂肪酸转运蛋白 5 (FATP5) 抑制剂,通过 FATP5 依赖性方式抑制原代肝细胞摄取长链脂肪酸。Ursodeoxycholic acid 能够抑制胆固醇的吸收,用于溶解胆结石,并具有研究与肥胖相关的脂肪肝疾病的潜力。 | |||
T29078 |
Ursodeoxycholic acid sodium
UDCA Na,UDCA sodium,Sodium Ursodeoxycholate,熊去氧胆酸钠盐,Ursodiol sodium,Ursodeoxycholic Acid (sodium salt),Ursodeoxycholate sodium |
FXR; Endogenous Metabolite; GPCR19 | GPCR/G Protein; Metabolism |
Ursodeoxycholic acid sodium (Sodium Ursodeoxycholate) 是一种天然存在的次级胆汁酸,具有抗炎和细胞保护活性。Ursodeoxycholic acid sodium 作为信号分子,通过与胆汁酸激活受体相互作用发挥其作用,包括 G 蛋白偶联胆汁酸受体 5 (TGR5) 和法尼醇 X 受体 (FXR)。 | |||
T5873 |
2,6-Dihydroxybenzoic acid
|
Endogenous Metabolite | Metabolism |
2,6-Dihydroxybenzoic acid 是一直水杨酸的次级代谢产物,在 I 期代谢过程中被肝酶水解。 | |||
TJS0318 |
6-Hydroxy-4-methylcoumarin
6-羟基-4-甲基香豆素,6-Hydroxy-4-Methyl-2H-Chromen-2-One,6-羟基-4-甲基香豆素;6-羟基-4-甲基-2H-1-苯并吡喃-2-酮 |
Others | Others |
6-Hydroxy-4-methylcoumarin (6-Hydroxy-4-Methyl-2H-Chromen-2-One) 是一种香豆素的次级代谢产物,具有抗癌作用。 | |||
T8120 |
N-Benzyloctadecanamide
N-苄基硬脂酰胺,N-Benzylstearamide |
Others | Others |
N-Benzyloctadecanamide 是一种 Macamide,Macamides 是Lepidium meyeniiWalp (玛咖)中的一类独特的次级代谢产物。 | |||
T9600 |
2,4-Di-tert-butylphenol
|
Endogenous Metabolite | Metabolism |
2,4-Di-tert-butylphenol 是一种人内源性代谢产物。 | |||
T8153 |
glycohyodeoxycholic acid
|
Others; Endogenous Metabolite | Metabolism; Others |
Glycohyodeoxycholic acid 是一种人体次级胆汁酸猪去氧胆酸的主要代谢物,能够预防胆结石的形成。 | |||
TCS1188 |
Mogroside III
|
Others | Others |
Mogroside III 是一种三萜糖苷和非糖甜味剂。 Mogroside III 被人体肠道细菌转化,释放出次生Mogroside IIA1 和苷元莫格罗。 | |||
T79972 |
Cyclo(L-leucyl-L-valyl)
|
Antifungal | Microbiology/Virology |
Cyclo(L-leucyl-L-valyl) 是从昆明链霉菌 YIM 次级代谢产物中部分离得到的多要化合物,尚未显示出抗菌活性。 | |||
T5234 |
Glycoursodeoxycholic acid
Ursodeoxycholylglycine,甘氨熊胆酸,GUDCA |
Others; Endogenous Metabolite | Metabolism; Others |
Glycoursodeoxycholic acid (Ursodeoxycholylglycine) 是一种酰基甘氨酸和胆汁酸-甘氨酸缀合物,是熊去氧胆酸的代谢物。 | |||
T8061 |
Citronellal
(±)-Citronellal,香茅醛 |
Others | Others |
Citronellal ((±)-Citronellal) 是多种芳香植物精油的单萜烯,具有促进睡眠、安定和抗伤害的作用。它可以降低机械伤害感受,且部分通过 NO-cGMP-ATP 敏感型 K⁺渠道通道介导的。 | |||
T22857 |
Illudin S
|
Apoptosis; DNA Alkylator/Crosslinker; Antifungal | Apoptosis; DNA Damage/DNA Repair; Microbiology/Virology |
Illudin S (ILS)是一种真菌倍半萜次生代谢物,具有很强的遗传毒性和细胞毒性 | |||
T7174 |
Urolithin A
尿石素A,3,8-二羟基-6H-二苯并[B,D]吡喃-6-酮 |
Apoptosis; Reactive Oxygen Species; DNA/RNA Synthesis; Endogenous Metabolite; Autophagy; Drug Metabolite | Apoptosis; Autophagy; Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Immunology/Inflammation; Metabolism; NF-κB |
Urolithin A 是一种鞣花酸的肠道微生物代谢产物,可诱导自噬和凋亡,抑制细胞周期进程,抑制DNA 合成,具有抗炎、抗增殖和抗氧化的特性。 | |||
T0019 |
Betaine chloride
Betaine hydrochloride,盐酸甜菜碱 |
Others; Chloride channel; Endogenous Metabolite | Membrane transporter/Ion channel; Metabolism; Others |
Betaine chloride (Betaine hydrochloride) 是一种天然化合物,在许多食物中能够发现,也是能够维持正常 DNA 甲基化模式的特性甲基供体。 | |||
T1048 |
Estradiol
雌二醇,E2,17β-Estradiol,17β-Oestradiol,β-Estradiol |
Estrogen Receptor/ERR; Estrogen/progestogen Receptor; Endogenous Metabolite | Endocrinology/Hormones; Metabolism |
Estradiol (E2) 是一种天然的类固醇性激素,对于女性生育能力和第二性征的维持至关重要。Estradiol 通过雌激素受体 β (ERβ) 上调 IL-6 表达。 | |||
T67731 |
Holomycin
N-Demethylthiolutin |
DNA/RNA Synthesis | Cell Cycle/Checkpoint; DNA Damage/DNA Repair |
Holomycin (N-Demethylthiolutin) 是二硫代吡咯酮类的次级代谢产物。 HolomycinHolomycin 是一种抗生素次级代谢物,是天然产光杆菌galatheae S2753形成生物膜所必需的,也是一种广谱抗生素。holomycin 通过其烯-二硫基团促进S2753的生物膜形成。 Holomycin 具有抗肿瘤活性,可参与 RNA 合成。 | |||
T8294 |
Quercetagitrin
万寿菊苷,槲皮万寿菊素-7-O-Β-吡喃葡萄糖苷,Quercetagetin-7-O-glucoside |
Others | Others |
Quercetagitrin 是分离自非洲万寿菊花 (Tagetes erecta) 中,具有抗炎作用。 | |||
T15091 |
Decoyinine
Decynylene,Angustmycin A |
||
Decoyinine (Decynylene) 是一种选择性的GMP 合成酶抑制剂,是一种新型的潜在微生物杀虫剂,是一种由透明链霉菌产生的次级代谢产物。Decoyinine 诱导水稻对小棕瓢虫Laodelphax striatellus 的抗性。 | |||
TN1765 |
Ingenol-3,4,5,20-diacetonide
巨大戟醇-3,4:5,20-双缩丙酮,Ingenol-3,4:5,20-diacetonide |
Others | Others |
Ingenol-3,4:5,20-diacetonide 是从大戟植物的汁液中分离出来的一种天然产物,它被发现具有广泛的生物活性,包括抗肿瘤、抗炎和免疫调节作用。 | |||
T15027 |
Cyclopiazonic acid
环匹阿尼酸,环二氮酸 |
Calcium Channel | Membrane transporter/Ion channel; Metabolism |
Cyclopiazonic acid 是一种神经毒性次级代谢产物 (SM),源于A. flavus,是一种纳摩尔内质网钙 ATP 酶抑制剂 (Ca2+ATPase; SERCA),是植物细胞死亡的有效诱导剂。 | |||
T4876 |
2-(1H-Indol-3-yl)ethan-1-ol
Tryptophol,3-(2-Hydroxyethyl)indole,Indole-3-ethanol,色醇 |
Others; Endogenous Metabolite | Metabolism; Others |
2-(1H-Indol-3-yl)ethan-1-ol (3-(2-Hydroxyethyl)indole) 是在双硫仑治疗后在肝脏中形成的代谢物,可诱导人类睡眠。它也是酒精发酵的二次产物。 | |||
T5254 |
Glycodeoxycholate Sodium
Sodium glycyldeoxycholate,Sodium glycodeoxycholate,Glycodeoxycholic acid sodium salt,脱氧甘胆酸钠 |
Others; Endogenous Metabolite | Metabolism; Others |
Glycodeoxycholate Sodium 诱导肝细胞凋亡的机制与内切酶的DNA裂解有关。它是一种次级胆汁酸,由结肠环境中微生物菌群中存在的酶的作用产生。 | |||
T1045 |
Trimipramine maleate
Surmontil maleate,马来酸三甲丙咪嗪,三甲丙咪嗪马来酸盐 |
Dopamine Receptor; 5-HT Receptor; Antibacterial; Adrenergic Receptor; Norepinephrine; Histamine Receptor | GPCR/G Protein; Immunology/Inflammation; Microbiology/Virology; Neuroscience |
Trimipramine maleate (Surmontil maleate) 是一种 5-HT 受体拮抗剂,对 5-HT1C、5-HT2和 5-HT1A 受体的 pKi 值分别为 6.39、8.10和 4.66。 | |||
T6520 |
Grape Seed Extract
Grape Seed P.E.,葡萄籽提取物 |
Apoptosis; Others | Apoptosis; Others |
Grape Seed Extract (Grape Seed P.E.) 是葡萄植物 Vitis vinifera 的种子分泌物,能诱导人类结肠直肠癌细胞凋亡,具有抗炎和抗增殖作用。它对脂肪代谢酶、胰脂肪酶和脂蛋白脂肪酶有抑制作用。 | |||
T0657 |
Veratryl alcohol
3,4-Dimethoxybenzyl alcohol,藜芦醇,3,4-二甲氧基苄醇 |
Others | Others |
3,4-Dimethoxybenzyl alcohol 是木质素降解真菌的次级代谢产物,通常作为非酚性底物测定木质素分解活性。Veratryl alcohol 保护木质素过氧化物酶 (LiP) 避免因为 H2O2 而失活并且防止 LiP III 化合物的累积[3] | |||
T8772 |
Sumaresinolic Acid
|
Others | Others |
Sumaresinolic Acid 是一种天然木脂素,存在于各种植物中,如亚麻籽、芝麻和麦麸,是植物的次生代谢产物,因其潜在的健康益处而被广泛研究,包括减少炎症、改善脂质代谢和提供抗氧化保护的能力。 | |||
TN5770 |
Gingerenone A
|
Nrf2 | Immunology/Inflammation |
Gingerenone A 是一种有效的 Nrf2-Gpx4 激活剂,是从生姜里面分离出来的小分子化合物,具有抗癌活性,可延长癌细胞的细胞周期,可抑制右旋糖酐硫酸钠 (DSS) 诱导的结肠炎小鼠继发性肝损伤 (SLI) 中的铁死亡。 | |||
T0729 |
Benzyl benzoate
Ascabiol,Novoscabin,Scabitox,苯甲酸苄酯,Benzoic acid benzyl ester |
Parasite | Microbiology/Virology |
Benzyl benzoate (Benzoic acid benzyl ester) 是化妆品中的香料成分,可研究疥疮和蠕形螨相关的炎症性皮肤病。 | |||
T5300 |
Ammonium formate
甲酸铵,Formic acid ammonium salt |
Others | Others |
Ammonium formate (Formic acid ammonium salt) 是最简单的羧酸。它通过抑制细胞色素氧化酶活性(电子传递链的末端电子受体)来负责代谢性酸中毒和破坏线粒体电子传递和能量产生。 | |||
T40790 |
ω-Muricholic Acid
|
Others | Others |
ω-Muricholic acid (ω-MCA) is a murine-specific secondary bile acid. | |||
T30407 |
Benzomalvin A
BenzomalvinA,Benzomalvin-A |
Others | Others |
Benzomalvin A is a filamentous fungal secondary metabolite. | |||
TN6536 |
Decuroside I
|
||
Decuroside I shows weak inhibiting activity against the primary and secondary wave aggregation of human platelet. | |||
T73893 |
1233B
|
Others | Others |
1233B 是丝状真菌Fusariumsp. RK97-94 的次级代谢产物。 | |||
T10074 |
2-Keto-D-Glucose
D-Glucosone |
Others | Others |
2-Keto-D-Glucose (D-Glucosone) is a key intermediate in a secondary metabolic pathway leading to the antibiotic Cortalcerone. It is found in various natural sources, including fungi, algae, and shellfish. | |||
T75479 |
Guignardone J
|
Others | Others |
Guignardone J 是从内生真菌 Phyllosticta capitalensis 中分离出的次级代谢产物。 | |||
TN3878 |
dl-Aloesol
|
Others | Others |
dl-Aloesol is a natural product from the secondary metabolites of endophytic fungus HCCB06030. | |||
T82437 |
Ethyl everninate
|
||
Ethyl everninate为从栎苔提取的一类阿屈醇衍生的次生代谢产物。 | |||
T16580 |
Prodigiosin
Prodigiosine,灵菌红素 |
Antifungal | Microbiology/Virology |
Prodigiosin is a secondary metabolite of Symbiotic bacteria. It also has anti-fungal and anti-cancer activity. | |||
T80940 |
Triptonoterpenol
|
||
Triptonoterpenol(化合物6)是雷公藤(Tripterygium wilfordii)的一种次级代谢产物。 | |||
T15111 |
Diacetoxyscirpenol
|
Others | Others |
Diacetoxyscirpenol, a trichothecene mycotoxin, is a secondary metabolite product of fungi. Diacetoxyscirpenol consumption induces hematological disorders in humans and animals. | |||
T75446 |
Viridin
|
Others | Others |
Viridin 是一种次生代谢物,是天然存在的呋喃甾体。Viridin 是脂质激酶 PI3K 的有效抑制剂。 | |||
T40643 |
Prodigiosin hydrochloride
盐酸灵菌红素,Prodigiosine hydrochloride |
Others | Others |
Prodigiosin hydrochloride, a red pigment, is a bioactive secondary metabolite produced by bacteria. It exhibits potent proapoptotic activity and functions as an inhibitor of the Wnt/β-catenin pathway. Additionally, this compound possesses antibacterial, antifungal, antiprotozoal, antimalarial, immunosuppressive, and anticancer properties. | |||
T82627 |
Cytochalasin O
|
||
Cytochalasin O (compound 13),为P. sp. CIB-109植物病原真菌的次级代谢产物。 | |||
T75454 |
Penicitide A
|
Others | Others |
Penicitide A 是一种海洋次生代谢产物。Penicitide A 对病原体 A.brassicae 和人肝细胞肝癌 (HepG2) 细胞系显示中度细胞毒性。 | |||
T38258 |
Phanerosporic Acid
|
Others | Others |
Phanerosporic acid is a fungal secondary metabolite originally isolated from P. chrysosporum that has antibacterial activity against B. cereus, B. subtilis, and E. coli and antifungal activity against S. cerevisiae, A. niger, O. ulmi, U. maydis, C. cucmerinum, C. cladosporioides, and B. cinerea.1 It has been used in the synthesis of macrolide derivatives.References1. Arnone, A., Assante, G., Nasini, G., et al. Phanerosporic acid, a β-resorcylate obtained from Phanerochaete chrysosporium. Phytoch... | |||
T74198 |
Beauverolide Ja
|
Others | Others |
Beauverolide Ja 是一种环四缩酚肽,是一种有效的钙调蛋白 (CaM) 抑制剂,对 Ca2+-CaM 的Kd 为 0.078 μM,Ki 为 0.39 μM。Beauverolide Ja 是Isaria fumosorosea 的次级代谢产物。 | |||
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Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPJ-00038 |
IL-7 Protein, Mouse, Recombinant (His)
interleukin-7,白介素,IL-7,IL-7 interleukin-7,PBGF,Lymphopoietin... |
Mouse | HEK293 Cells |
Mouse interleukin-7(IL-7) is the member of hemopoietin family which is important to the differentiation, proliferation, and survival of lymphocyte. Mouse IL-7 shares approximately 88% aa sequence identity with rat IL-7 and 58-60% with human, equine, bovine, ovine, porcine, feline and canine IL-7. It is widely expressed in primary and secondary lymphoid tissues cell and stromal epithelial cells of the thymus, bone marrow, and intestines. IL-7 activation of IL-7 R alpha is critical for both T cell... | |||
TMPJ-00994 |
LTBR Protein, Mouse, Recombinant (hFc)
Tnfcr,Lymphotoxin-beta receptor,Tumor necrosis factor recept... |
Mouse | HEK293 Cells |
It is a single-pass type I membrane protein and contains 4 TNFR-Cys repeats. The protein is a member of the tumor necrosis factor (TNF) family of receptors. It is expressed on the surface of most cell types, including cells of epithelial and myeloid lineages, but not on T and B lymphocytes. The protein is the receptor for the heterotrimeric lymphotoxin containing LTA and LTB, and for TNFS14/LIGHT. It promotes apoptosis via TRAF3 and TRAF5 and may play a role in the development of lymphoid organs... | |||
TMPY-02153 |
TNF beta Protein, Human, Recombinant
LT,TNF β,TNFSF1,肿瘤坏死因子,TNFB,lymphotoxin alpha,lymphotoxin α |
Human | E. coli |
Lymphotoxin-alpha, also known as LT-alpha, TNF-beta, Tumor necrosis factor ligand superfamily member 1, LTA TNFSF1, and TNFB, is a secreted protein that belongs to the tumor necrosis factor family. TNF-beta/TNFSF1/Lymphotoxin alpha is highly inducible, secreted, and exists as a homotrimeric molecule. It is a cytokine that in its homotrimeric form binds to TNFRSF1A / TNFR1, TNFRSF1B / TNFBR, and TNFRSF14 / HVEM. In its heterotrimeric form with LTB, TNF-beta/TNFSF1/Lymphotoxin alpha binds to TNFRS... | |||
TMPK-01131 |
Neogenin Protein, Human, Recombinant (hFc)
NEO,NGN,IGDCC2,NEO1,neogenin 1 |
Human | HEK293 Cells |
Neogenin is a multifunctional transmembrane receptor belonging to the immunoglobulin superfamily. It displays identical secondary structure to deleted in colorectal cancer (DCC), a netrin receptor that is involved in axon guidance and cell survival. | |||
TMPH-02385 |
Lake Victoria marburgvirus (MARV) (strain Musoke-80) VP30 Protein (His & Myc)
Minor nucleoprotein VP30,Transcriptional activator VP30,VP30 |
MARV | E. coli |
Acts as a transcription anti-termination factor immediately after transcription initiation, but does not affect transcription elongation. This function has been found to be dependent on the formation of an RNA secondary structure at the transcription start site of the first gene. | |||
TMPH-01313 |
EIF4G1 Protein, Human, Recombinant (His)
EIF4G,eIF-4-gamma 1,Eukaryotic translation initiation factor... |
Human | P. pastoris (Yeast) |
Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome. As a member of the eIF4F complex, required for endoplasmic reticulum stress-induced ATF4 mRNA translation. EIF4G1 Protein, Human, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 41.6 kDa and the accession number is Q04637. | |||
TMPH-00091 |
UGT71C1 Protein, Arabidopsis thaliana, Recombinant (Baculovirus, His)
Flavonol 3-O-glucosyltransferase UGT71C1,UGT71C1,Flavonol 7-... |
Arabidopsis thaliana | P. pastoris (Yeast) |
Possesses quercetin 7-O-glucosyltransferase and 3'-O-glucosyltransferase activities in vitro. Also active in vitro on benzoates and benzoate derivatives. Glucosylates other secondary metabolites in vitro like trans-resveratrol, curcumin, vanillin and etoposide. UGT71C1 Protein, Arabidopsis thaliana, Recombinant (Baculovirus, His) is expressed in yeast with N-10xHis tag. The predicted molecular weight is 56.4 kDa and the accession number is O82381. | |||
TMPK-00167 |
OX40/TNFRSF4 Protein, Human, Recombinant (His & Avi)
OX40 homologue,Ly-70,OX40, TXGP1L,OX40L receptor,IMD16,CD134... |
Human | HEK293 Cells |
Tumor necrosis factor receptor superfamily, member 4 (TNFRSF4), also known as CD134 and OX40 receptor. OX40 is a secondary co-stimulatory immune checkpoint molecule, expressed after 24 to 72 hours following activation; its ligand, OX40L, is also not expressed on resting antigen presenting cells, but is following their activation. OX40/TNFRSF4 Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 23.2 kDa and the acces... | |||
TMPH-00090 |
UGT71C1 Protein, Arabidopsis thaliana, Recombinant (E. coli, His)
Flavonol 7-O-beta-glucosyltransferase UGT71C1,UGT71C1,Flavon... |
Arabidopsis thaliana | E. coli |
Possesses quercetin 7-O-glucosyltransferase and 3'-O-glucosyltransferase activities in vitro. Also active in vitro on benzoates and benzoate derivatives. Glucosylates other secondary metabolites in vitro like trans-resveratrol, curcumin, vanillin and etoposide. UGT71C1 Protein, Arabidopsis thaliana, Recombinant (E. coli, His) is expressed in E. coli expression system with N-10xHis tag. The predicted molecular weight is 59.4 kDa and the accession number is O82381. | |||
TMPK-00169 |
OX40/TNFRSF4 Protein (Primary Amine Labeling), Human, Recombinant (hFc), Biotinylated
IMD16,ACT-135,OX40 homologue,Ly-70, TXGP1L,TNFRSF4,OX40,OX40... |
Human | HEK293 Cells |
Tumor necrosis factor receptor superfamily, member 4 (TNFRSF4), also known as CD134 and OX40 receptor. OX40 is a secondary co-stimulatory immune checkpoint molecule, expressed after 24 to 72 hours following activation; its ligand, OX40L, is also not expressed on resting antigen presenting cells, but is following their activation. OX40/TNFRSF4 Protein (Primary Amine Labeling), Human, Recombinant (hFc), Biotinylated is expressed in HEK293 mammalian cells with C-hFc tag. The predicted molecular wei... | |||
TMPK-00464 |
OX40/TNFRSF4 Protein, Mouse, Recombinant (His & Avi), Biotinylated
CD134,TXGP1L,ACT-135,Ly-70,OX40,Txgp1,OX40L receptor,TNFRSF4 |
Mouse | HEK293 Cells |
Tumor necrosis factor receptor superfamily, member 4 (TNFRSF4), also known as CD134 and OX40 receptor. OX40 is a secondary co-stimulatory immune checkpoint molecule, expressed after 24 to 72 hours following activation; its ligand, OX40L, is also not expressed on resting antigen presenting cells, but is following their activation. OX40/TNFRSF4 Protein, Mouse, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 24.2 kDa... | |||
TMPY-02807 |
TWSG1 Protein, Mouse, Recombinant (His)
Twg,Twsg1,9030422N06Rik,AW552143,twisted gastrulation homolo... |
Mouse | HEK293 Cells |
TWSG1 belongs to the twisted gastrulation protein family. TWSG1 from different species are functionally equivalent. In contrast to Drosophila where TWSG1 expression is limited to early embryos, expression of TWSG1 is found throughout mouse and human development. Mutations in the TWSG1 gene cause at least some of the cells on the dorsal half of the embryo to adopt more ventral cell fates. This is thought to involve gradients of the signaling molecule decapentaplegic. TWSG1 may function as a bone ... | |||
TMPK-00463 |
OX40/TNFRSF4 Protein, Mouse, Recombinant (His & Avi)
CD134,OX40 homologue,OX40,IMD16,OX40L receptor, TXGP1L,TNFRS... |
Mouse | HEK293 Cells |
Tumor necrosis factor receptor superfamily, member 4 (TNFRSF4), also known as CD134 and OX40 receptor. OX40 is a secondary co-stimulatory immune checkpoint molecule, expressed after 24 to 72 hours following activation; its ligand, OX40L, is also not expressed on resting antigen presenting cells, but is following their activation. OX40/TNFRSF4 Protein, Mouse, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 24.2 kDa and the acces... | |||
TMPH-01312 |
EIF4G1 Protein, Human, Recombinant (B2M & His & JD & Myc)
eIF-4G 1,EIF4G,Eukaryotic translation initiation factor 4 ga... |
Human | E. coli |
Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome. As a member of the eIF4F complex, required for endoplasmic reticulum stress-induced ATF4 mRNA translation. EIF4G1 Protein, Human, Recombinant (B2M & His & JD & Myc) is expressed in E. coli expression system with N-10xHis-B2M-JD and C-Myc tag. The predicted molecular weight is 46.6 kDa and the accession nu... | |||
TMPK-00168 |
OX40/TNFRSF4 Protein, Human, Recombinant (aa 29-216, His & Avi), Biotinylated
IMD16,TNFRSF4,CD134,ACT-135, TXGP1L,OX40 homologue,OX40,OX40... |
Human | HEK293 Cells |
Tumor necrosis factor receptor superfamily, member 4 (TNFRSF4), also known as CD134 and OX40 receptor. OX40 is a secondary co-stimulatory immune checkpoint molecule, expressed after 24 to 72 hours following activation; its ligand, OX40L, is also not expressed on resting antigen presenting cells, but is following their activation. OX40/TNFRSF4 Protein, Human, Recombinant (aa 29-216, His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight ... | |||
TMPJ-00507 |
EIF4E Protein, Human, Recombinant
eIF-4F 25 kDa subunit,EIF4F,eIF-4E,Eukaryotic translation in... |
Human | E. coli |
Eukaryotic translation initiation factor 4E is a 217 amino acids protein that belongs to the eukaryotic initiation factor 4E family. eIF4F is a multi-subunit complex, the composition of which varies with external and internal environmental conditions. It is composed of at least EIF4A, EIF4E and EIF4G1/EIF4G3. EIF4E is also known to interact with other partners.It can recognize and bind the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facil... | |||
TMPJ-00582 |
PRG3 Protein, Human, Recombinant (His)
Prepro-MBPH,Prepro-Major Basic Protein Homolog,Eosinophil Ma... |
Human | HEK293 Cells |
Proteoglycan 3, also known as Eosinophil major basic protein homolog, Prepro-major basic protein homolog, PRG3 and MBPH, contains one C-type lectin domain. Proteoglycans are a major component of the animal extracellular matrix. PRG3 localizes to the eosinophil secondary granule and is expressed in bone marrow, not detected in placenta. PRG3 has similar cytotoxic and cytostimulatory activities to PRG2/MBP. In vitro, PRG3 can stimulate neutrophil superoxide production and IL8 release, histamine an... | |||
TMPH-01306 |
EIF4A1 Protein, Human, Recombinant (His & Myc)
eIF4A-I,EIF4A1,eIF-4A-I,Eukaryotic initiation factor 4A-I,EI... |
Human | E. coli |
ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon. EIF4A1 Protein, Human, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The ... | |||
TMPY-04464 |
GALK1 Protein, Human, Recombinant (His & GST)
galactokinase 1,HEL-S-19,GALK,GK1 |
Human | Baculovirus Insect Cells |
Galactokinase, also known as Galactose kinase, GALK and GALK1, is a protein which belongs to theGHMP kinase family and GalK subfamily. Galactokinase / GALK1 is a major enzyme for galactose metabolism. Galactokinase (GALK) deficiency is an autosomal recessive disorder characterized by elevation of blood galactose concentration and diminished galactose-1-phosphate, leading to the production of galactitol. Defects in GALK1 are the cause of galactosemia II ( GALCT2 ) which II is an autosomal ... | |||
TMPH-00532 |
SSB Protein, Enterobacteria phage T7, Recombinant
Gene product 2.5,Single-stranded DNA-binding protein,2.5 pro... |
Enterobacteria phage T7 | P. pastoris (Yeast) |
Single-stranded DNA-binding protein that participates in viral DNA replication, formation of concatemers, recombination and repair of double-stranded breaks. Coats the lagging-strand ssDNA as the replication fork advances and stimulates the activities of viral DNA polymerase and primase/helicase. Coordinates simultaneous synthesis of leading- and lagging-strands. Together with DNA primase/helicase, promotes pairing of two homologous DNA molecules containing complementary single-stranded regions ... | |||
TMPJ-00997 |
GALK1 Protein, Human, Recombinant (His)
Galactokinase,Galactose Kinase,GALK1,GALK |
Human | E. coli |
Galactokinase belongs to the GHMP kinase family and GalK subfamily. Galactokinase is more important to the galactose metabolism pathway. It modifies galactose to create a similar molecule called Galactose-1-Phosphate.Thus, a series of additional steps converts Galactose-1-Phosphate to another simple sugar Glucose, which is the main energy source for most cells. Galactokinase deficiency results in Galactosemia II, an autosomal recessive deficiency characterized by congenital cataracts during infa... | |||
TMPH-00531 |
SSB Protein, Enterobacteria phage T7, Recombinant (His & SUMO)
Single-stranded DNA-binding protein,Gene product 2.5,2.5 pro... |
Enterobacteria phage T7 | E. coli |
Single-stranded DNA-binding protein that participates in viral DNA replication, formation of concatemers, recombination and repair of double-stranded breaks. Coats the lagging-strand ssDNA as the replication fork advances and stimulates the activities of viral DNA polymerase and primase/helicase. Coordinates simultaneous synthesis of leading- and lagging-strands. Together with DNA primase/helicase, promotes pairing of two homologous DNA molecules containing complementary single-stranded regions ... | |||
TMPJ-00971 |
PPIC Protein, Human, Recombinant (Trx & His)
PPIase C,Peptidyl-Prolyl Cis-Trans Isomerase C,PPIC,Cyclophi... |
Human | E. coli |
Cyclophilin C is an enzyme (EC 5.2.1.8) found in both prokaryotes and eukaryotes that interconverts the cis and trans isomers of peptide bonds with the amino acid proline. Proline has an unusually conformationally restrained peptide bond due to its cyclic structure with its side chain bonded to its secondary amine nitrogen. Most amino acids have a strong energetic preference for the trans peptide bond conformation due to steric hindrance, but prolines unusual structure stabilizes the cis form so... | |||
TMPJ-00597 |
IgG1 hFc Protein, Mouse, Recombinant
g γ-1 chain C region,g gamma-1 chain C region,IGHG1 |
Mouse | HEK293 Cells |
As a monomeric immunoglobulin that is predominately involved in the secondary antibody response and the only isotype that can pass through the human placenta, Immunoglobulin G (IgG) is synthesized and secreted by plasma B cells. IgG antibodies protect the body against the pathogens by agglutination and immobilization, complement activation, toxin neutralization, as well as the antibody-dependent cell-mediated cytotoxicity (ADCC). IgG tetramer contains two heavy chains (50 kDa ) and two light cha... | |||
TMPH-03729 |
Zaire ebolavirus (strain Kikwit-95) VP30 Protein (His)
Transcriptional activator VP30,EbolaVP30,Minor nucleoprotein... |
ZEBOV | E. coli |
Multifunctional protein that acts as a viral transcriptional activator. Promotes read-through of an RNA hairpin in the NP open reading frame to enhance viral transcription. Mechanistically, nonphosphorylated VP30 hexamers form a ternary complex with the viral leader RNA. Clamps the RNA template and the complex VP35-polymerase L together, thereby increasing the polymerase affinity for the RNA template to increase transcription initiation despite the presence of RNA secondary structures. Assists a... | |||
TMPY-00323 |
Hepatitis C virus (HCV-1a) NS3 protease/helicase immunodominant region Protein (aa 1356-1459, GST)
NS3 |
HCV | E. coli |
HCV NS3 displays three enzymatic activities: serine protease, NTPase, and RNA helicase. HCV NS3 serine protease, in association with NS4A, is responsible for the cleavages of NS3-NS4A, NS4A-NS4B, NS4B-NS5A, and NS5A-NS5B. HCV NS3 RNA helicase binds to RNA and unwinds dsRNA in the 3' to 5' direction, and likely RNA stable secondary structure in the template strand (By similarity). Cleaves and inhibits the host antiviral protein MAVS. NS3/NS4A complex also prevents phosphorylation of human IRF3, t... | |||
TMPY-01960 |
Munc18c/STXBP3 Protein, Human, Recombinant (His & GST)
syntaxin binding protein 3,MUNC18C,UNC-18C,MUNC18-3,PSP |
Human | Baculovirus Insect Cells |
Syntaxin-binding protein 3, also known as Platelet Sec1 protein, Protein unc-18 homolog 3, Protein unc-18 homolog C, Unc-18C, Unc18-3 and STXBP3, is a cytoplasm protein which belongs to the STXBP/unc-18/SEC1 family. STXBP3 is expressed in cells that exhibit granule exocytosis, such as neutrophils, mast cells, platelets and endothelial cells. STXBP3, together with STX4 and VAMP2, may play a role in insulin-dependent movement of GLUT4 and in docking / fusion of intracellular GLUT4-containing vesic... | |||
TMPJ-01166 |
IGFBP-7 Protein, Mouse, Recombinant (His)
TAF,IGFBP-rP1,Insulin-like growth factor-binding protein 7,T... |
Mouse | HEK293 Cells |
Insulin-like growth factor-binding protein 7(IGFBP-7) is a secreted glycosylated protein that contains three protein domain modules. IGFBP7 contains an N-terminal IGFBP domain, followed by a Kazal-type serine proteinase inhibitor domain and a C-terminal immunoglobulin-like C2-type domain. Human and mouse IGFBP7 are highly homologous and share 94% aa sequence identity. It is expressed in many normal tissues and in cancer cells. It is abundantly expressed in high endothelial venules (HEVs) of bloo... | |||
TMPJ-00684 |
SNCA Protein, Mouse, Recombinant (His)
Snca,Non-A β component of AD amyloid,Non-A4 component of amy... |
Mouse | E. coli |
Alpha-synuclein (Snca) belongs to a family of proteins including a-, b-, and g-synucleins. Alpha-synuclein has been found to be implicated in the pathophysiology of many neurodegenerative diseases, including Parkinson's disease (PD) and Alzheimer's disease. Manyneurodegenerative diseases has shown that alpha-synuclein accumulates in dystrophic neurites and in Lewy bodies. The function of alpha-synuclein is closely correlated with its three-dimensional structure, especially for proteins important... | |||
TMPJ-00029 |
CALM1 Protein, Human, Recombinant
Calmodulin,CAMIII,CAMC,CALM,CALML2,CALM2,CAM2,CALM3,CAM1,CAM... |
Human | E. coli |
Calmodulin (CaM) is a multifunctional intermediate calcium-binding messenger protein expressed in all eukaryotic cells. It is an intracellular target of the secondary messenger Ca2+, and the binding of Ca2+ is required for the activation of Calmodulin. Once bound to Ca2+, Calmodulin acts as part of a calcium signal transduction pathway by modifying its interactions with various target proteins such as kinases or phosphatases. Calmodulin is a small, highly conserved protein that is 148 amino acid... | |||
TMPY-01992 |
Kallikrein 8/KLK8 Protein, Human, Recombinant (His)
kallikrein-related peptidase 8,PRSS19,TADG14,NRPN,NP,HNP |
Human | HEK293 Cells |
Kallikrein-8, also known as Neuropsin, Serine protease 19, Serine protease TADG-14, Tumor-associated differentially expressed gene 14 protein, and KLK8 is a secreted protein that belongs to the peptidase S1 family and Kallikrein subfamily. It is a serine protease that is capable of degrading some proteins such as casein, fibrinogen, kininogen, fibronectin, and collagen type IV. Kallikrein-8 / KLK8 plays a role in the formation and maturation of orphan and small synaptic boutons in the Schaffer-c... | |||
TMPY-01900 |
Kallikrein 4/KLK4 Protein, Human, Recombinant (His)
PSTS,kallikrein,kallikrein-related peptidase 4,EMSP,EMSP1,AR... |
Human | HEK293 Cells |
Kallikrein-4, also known as Enamel matrix serine proteinase 1, Kallikrein-like protein 1, KLK-L1, Serine protease 17, KLK4, PRSS17, and EMSP1, is a secreted protein that belongs to the peptidase S1 family and Kallikrein subfamily. Kallikrein-4 / KLK4 is a serine protease expressed during enamel maturation, and proteolytic processing of the enamel matrix by KLK4 is critical for proper enamel formation. Kallikrein-4 / KLK4 contains one peptidase S1 domain. Kallikrein-4 / KLK4 is secreted by transi... | |||
TMPJ-00605 |
GPVI Protein, Mouse, Recombinant (His)
Glycoprotein 6,GP6,glycoprotein VI (platelet),GPVI,GPIV,MGC1... |
Mouse | HEK293 Cells |
Glycoprotein VI (GPVI) is a 63 kDa platelet/megakaryocyte-specific type I transmembrane glycoprotein of the immunoglobulin superfamily that is an important collagen receptor and initiator of platelet activation, aggregation and thrombin generation. GPVI is also a secondary receptor required for platelet spreading on laminin. GPVI associates with the Fc receptor gamma -chain via charged aa in the TM domains of GPVI (arginine) and the FcR gamma (aspartic acid). Collagen binding by the GPVI Ig-like... | |||
TMPY-02063 |
Alpha-2-macroglobulin Protein, Human, Recombinant (His)
α-2-macroglobulin,FWP007,CPAMD5,A2MD,S863-7,alpha-2-macroglo... |
Human | Baculovirus Insect Cells |
alpha-2-macroglobulin, also known as α2-macroglobulin (α2M and A2M), is an abundant protein of the plasma of vertebrates and members of several invertebrate phyla and functions as a broad-spectrum protease-binding protein. alpha-2-macroglobulin is produced by the liver, and is a major component of the alpha-2 band in protein electrophoresis. alpha-2-macroglobulin is a large plasma glycoprotein that has long been known as an irreversible inhibitor of a variety of proteinases. More recently, it ha... | |||
TMPJ-00751 |
IgG4 hFc Protein, Human, Recombinant (aa 99-326)
IgG4 Fc,Ig γ-4 chain C region,Ig gamma-4 chain C region |
Human | HEK293 Cells |
As a monomeric immunoglobulin that is predominately involved in the secondary antibody response and the only isotype that can pass through the human placenta, Immunoglobulin G (IgG) is synthesized and secreted by plasma B cells, and constitutes 75% of serum immunoglobulins in humans. IgG antibodies protect the body against the pathogens by agglutination and immobilization, complement activation, toxin neutralization, as well as the antibody-dependent cell-mediated cytotoxicity (ADCC). IgG tetram... | |||
TMPY-00886 |
MMP-1 Protein, Human, Recombinant (His)
CLGN,CLG,matrix metallopeptidase 1 |
Human | HEK293 Cells |
MMP1, also known as MMP-1, contains 4 hemopexin-like domains and is a member of the matrix metalloproteinase (MMP) family. Matrix metalloproteases, also called matrixins, are zinc-dependent endopeptidases that are the major proteases involved in ECM degradation. MMPs are capable of degrading a wide range of extracellular molecules and some bioactive molecules. MMP activity is regulated by two major endogenous inhibitors: alpha2-macroglobulin and tissue inhibitors of metalloproteases (TIMPs). MMP... | |||
TMPY-03105 |
Ki67/MKI67 Protein, Human, Recombinant (GST)
MIB-1,PPP1R105,marker of proliferation Ki-67,MIB-,KIA |
Human | E. coli |
MKI67 contains 1 FHA domain and plays a key role in cell proliferation. During interphase, the MKI67 antigen can be exclusively detected within the cell nucleus, whereas in mitosis most of the protein is relocated to the surface of the chromosomes. MKI67 protein is present during all active phases of the cell cycle (G1, S, G2, and mitosis), but is absent from resting cells. MKI67 is an excellent marker to determine the growth fraction of a given cell population. The fraction of MKI67-positive tu... |
Cat. No. | Product Name | Target | Signaling Pathways |
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T12363 |
Paricalcitol-D6
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Others | Others |
Paricalcitol-D6 is the deuterated form of Paricalcitol, which is used for the prevention and treatment of secondary hyperparathyroidism (excessive secretion of parathyroid hormone) associated with chronic renal failure. | |||
TMIH-0257 |
Glycoursodeoxycholic Acid-d4
|
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Glycoursodeoxycholic Acid-d4 是 Glycoursodeoxycholic Acid 的氘代化合物。Glycoursodeoxycholic Acid 的 CAS 号为 64480-66-6。Glycoursodeoxycholic acid 是一种酰基甘氨酸和胆汁酸-甘氨酸缀合物,是熊去氧胆酸的代谢物。 | |||
TMIH-0322 |
Mebeverine Acid-d5
|
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Mebeverine Acid-d5 是 Mebeverine Acid 的氘代化合物。Mebeverine Acid 的 CAS 号为 475203-77-1。Mebeverine acid 是美贝维林的次级代谢产物,可用作口服美贝维林的标志物。 | |||
TMIH-0184 |
Desipramine-d3 HCl
|
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Desipramine-d3 HCl 是 Desipramine HCl 的氘代化合物。Desipramine HCl 的 CAS 号为 58-28-6。Desipramine hydrochloride 是一种二苯并氮杂类衍生物三环类抗抑郁药,可作为选择性去甲肾上腺素再摄取抑制剂。 它还显示出较弱的 5-羟色胺再摄取抑制、α1 阻断、抗组胺和抗胆碱能作用。 | |||
TMIJ-0252 |
Benazeprilat-d5
Benazepril EP Impurity C-d5 |
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Benazeprilat-d5 是 Benazeprilat 的氘代化合物。Benazeprilat 的 CAS 号为 86541-78-8。Benazeprilat(CGS 14831) 是一种具有口服活性的贝那普利活性代谢物。Benazeprilat 具有高效的抗血压活性,可与其他其他类别的化合物(包括噻嗪类利尿剂和钙通道阻滞剂)联合使用来减少与心血管风险和继发性终末器官损伤相关的疾病的发生。Benazeprilat 可能用于研究急性左心室衰竭。 |