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Cat. No. | Product Name | ||
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L7900 | 成骨分子库 | 317 compounds | |
317 种成骨相关的生物活性小分子化合物的特有集合,用于高通量、高内涵筛选; |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T37603L |
Osteogenic Growth Peptide (10-14) acetate
Osteogenic Growth Peptide (10-14) acetate(105250-85-9 Free base) |
Src | Angiogenesis; Tyrosine Kinase/Adaptors |
Osteogenic Growth Peptide (10-14) acetate (Osteogenic Growth Peptide) 是一种 Src 抑制剂,是一种有效的有丝分裂原和促成骨和造血因子。Osteogenic Growth Peptide (10-14) acetate 负责与 OGP 受体结合并激活细胞内 Gi 蛋白激酶信号通路。 | |||
TP1820L |
Osteogenic Growth Peptide, OGP acetate
Osteogenic Growth Peptide, OGP acetate(132996-61-3 free base) |
Others | Others |
Osteogenic Growth Peptide, OGP acetate(132996-61-3 free base) 是一种短的、天然存在的 14 聚体生长因子肽,存在于血清中,浓度为 μM。成骨生长肽 OGP 是局部骨髓损伤全身成骨反应机制的关键因素。 | |||
T37603 |
Osteogenic Growth Peptide (10-14)
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YGFGG, C-terminal pentapeptide fragment of the osteogenic growth peptide (OGP), (H-8640), showed the full spectrum of OGP-like bioactivities. It has attracted considerable interest as bone anabolic agent and hematopoietic stimulator. | |||
TP1820 |
Osteogenic Growth Peptide, OGP
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Osteogenic Growth Peptide, OGP is a short, naturally occurring 14-mer growth factor peptide found in serum at μM concentrations. Osteogenic growth peptide OGP is a key factor in the mechanism of the systemic osteogenic response to local bone marrow injury | |||
T4205 |
AG-494
Tyrphostin AG-494,AG 494,Tyrphostin B48 |
EGFR; CDK | Angiogenesis; Cell Cycle/Checkpoint; JAK/STAT signaling; Tyrosine Kinase/Adaptors |
AG-494 (Tyrphostin B48) 是一种高效、选择性的 EGFR 酪氨酸激酶抑制剂,IC50为0.7 μM。它阻断 Cdk2 的激活并抑制 EGF 依赖的 DNA 合成。它抑制 EGFR、ErbB2、HER1-2 和 PDGF-R 的自磷酸化,IC50为 1.1、39、45 和 6 μM。 | |||
T19389 |
L-Ascorbic acid 2-phosphate magnesium
2-Phospho-L-ascorbic acid magnesium,维生素C磷酸酯镁,维生素 C 磷酸酯镁 |
Phosphatase; Phosphorylase | Metabolism |
L-Ascorbic acid 2-phosphate magnesium (2-Phospho-L-ascorbic acid magnesium) 是长效的维生素 C 衍生物,能够以刺激胶原蛋白的表达和形成。它提高成骨细胞分化过程中 hASC 中的碱性磷酸酶特性和 runx2A 的表达。它能够以作为培养基补充人脂肪干细胞的成骨分化。 | |||
T67855 |
ISX-3
|
Others | Others |
ISX-3 是有效的促成骨剂和抗脂肪生成剂。ISX-3 可以增加 PPARγ 的表达。ISX-3 可用于研究骨质减少和骨质疏松症。 | |||
T61301 |
Chromenone 1
|
TGF-beta/Smad | Stem Cells |
Chromenone 1 是一种有效的成骨骨形态发生蛋白(BMP)增强剂,其通过诱导显著的非激酶依赖的负TGFβ反馈,独特地增强了核BMP-Smad信号输出。 | |||
T35694 |
OD36
OD 36,OD 36 hydrochloride,OD-36 |
ALK; RIP kinase | Angiogenesis; Apoptosis; NF-κB; Tyrosine Kinase/Adaptors |
OD36 是一种选择性强效 RIPK2 抑制剂,IC50 为 5.3 nM。OD36 可抑制 ALK2 信号传导和成骨分化(KD:37 nM),并能与 ALK2 激酶 ATP 袋有效结合。 | |||
T19390 |
L-Ascorbic acid 2-phosphate
维生素C磷酸酯,2-Phospho-L-ascorbic acid |
Others | Others |
L-ascorbic acid 2-phosphate can be used as a culture medium supplement for the osteogenic differentiation of human adipose stem cells (hASCs). L-ascorbic acid 2-phosphate increases alkaline phosphatase (ALP) activity and expression of runx2A in hASCs during the osteogenic differentiation. L-ascorbic acid 2-phosphate is a long-acting vitamin C derivative that can stimulate collagen formation and expression. | |||
T124960 |
Avenacoside B
|
Others | Others |
Avenacoside B 可从燕麦中提取,具有抗线虫活性,可增强成骨活性。 | |||
T76798 |
Bimekizumab
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Bimekizumab (Anti-Human IL17A/IL-17F Recombinant Antibody) 是一种人源化单克隆抗体,可选择性中和 IL-17A 和 IL-17F。这两种细胞因子都能够促进成骨的人骨膜衍生细胞 (hPDC) 分化。因此,Bimekizumab 的应用,可以阻断炎症驱动的成骨分化。 | |||
T31124 |
CW 008
CW-008,CW008 |
Others | Others |
CW 008 is an activator of the cAMP/PKA/CREB pathway. It promotes osteogenic differentiation of human bone marrow derived mesenchymal stem cells in vitro and increases bone mass and bone volume density in ovariectomized mice. | |||
T81406 |
Preptin (rat)
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Preptin 在剂量依赖的方式下刺激胎鼠原代成骨细胞和成骨样细胞系的增殖,影响表现在细胞数量和DNA合成上。 | |||
T82929 |
AVSEHQLLHDKGKSIQDLRRRFFLHHLI-{Aib}-EIHTAYRFGG
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AVSEHQLLHDKGKSIQDLRRRFFLHHLI-{Aib}-EIHTAYRFGG 促进骨化作用。该化合物适用于研究成骨缺陷或骨矿物质密度(BMD)降低相关疾病,如骨质疏松症。 | |||
T82851 |
BMP2-derived peptide
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BMP2-derived peptide为BMP-2第73至92位氨基酸序列的功能性基序,具有促进骨髓基质细胞(BMSCs)成骨分化及骨再生的作用。 | |||
T61424 |
OD36 hydrochloride
OD 36 hydrochloride,OD-36 hydrochloride |
ALK; RIP kinase | Angiogenesis; Apoptosis; NF-κB; Tyrosine Kinase/Adaptors |
OD36 hydrochloride (OD-36 hydrochloride) 是一种强效的 RIPK2 抑制剂,IC50 为 5.3 nM。OD36 hydrochloride 是一种大环抑制剂,可与 ALK2 激酶 ATP 口袋有效结合,能有效拮抗突变 ALK2 信号传导和成骨分化。OD36 hydrochloride 靶向作用于 ALK2,KD 为 37 nM。 | |||
T83848 |
VnP-16 TFA
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VnP-16是一种合成肽段,对应vitronectin的氨基酸270-281,vitronectin是一种具有细胞附着、迁移和扩散等多功能作用的糖蛋白。该肽段在9.1 µg/cm2浓度下应用于细胞板时,能促进人类成骨细胞的附着和扩散,此效应可通过β1整合素的siRNA敲除被逆转。VnP-16诱导人类皮肤来源的间充质前体细胞和MC3T3-E1小鼠颅骨成骨前体细胞的成骨作用。在体内,VnP-16减少IL-1α诱导的骨质流失并减少小鼠颅骨中破骨细胞的数量。它还在卵巢切除引起的骨质疏失小鼠模型中增加骨矿物质密度并减少松质骨流失。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
TN1124 |
Neoeriocitrin
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AChE | Neuroscience |
Neoeriocitrin 是一种有效的乙酰胆碱酯酶抑制剂,分离于自百日草,在 MC3T3-E1 中显示出对增殖和成骨分化的活性。 | |||
TN7036 |
N-(3-Methoxybenzyl)-(9Z,12Z,15Z)-octadecatrienamide
(9Z,12Z,15Z)-N-[(3-Methoxyphenyl)methyl]-9,12,15-octadecatrienamide,间-甲氧基苄基-亚麻酰胺,Macamide Impurity 14 |
Wnt/beta-catenin | Cytoskeletal Signaling; Stem Cells |
N-(3-Methoxybenzyl)-(9Z,12Z,15Z)-octadecatrienamide (Macamide Impurity 14) 是一种从玛卡中分离得到的玛卡酰胺。它能够激活典型的Wnt/β‐catenin 信号通路,诱导间充质干细胞成骨分化和随后的骨形成,可用于研究骨质疏松症。 | |||
T2185 |
L-Ascorbic acid 2-phosphate trisodium
L-抗坏血酸-2-磷酸三钠盐(维生素C),L-Ascorbic acid 2-phosphate trisodium salt,Sodium L-ascorbyl-2-phosphate,Sodium ascorbyl phosphate,2-Phospho-L-ascorbic acid trisodium salt,Sodium ascorbyl monophosphate,L-抗坏血酸-2-磷酸三钠盐 |
Reactive Oxygen Species; c-Met/HGFR; Endogenous Metabolite | Immunology/Inflammation; Metabolism; NF-κB; Tyrosine Kinase/Adaptors |
L-Ascorbic acid 2-phosphate trisodium (Sodium ascorbyl phosphate) 是长效的维生素 C 衍生物,能够刺激胶原蛋白的表达和形成。Sodium L-ascorbyl-2-phosphate 提高成骨细胞分化过程中 hASC 中的碱性磷酸酶活性和 runx2A 的表达,因此,能够促进人脂肪干细胞的成骨分化。 | |||
T5S0836 |
Isoastragaloside II
黄芪甲苷VII,Astrasieversianin VII |
Others | Others |
Isoastragaloside II (Astrasieversianin VII) 是一种是从黄芪毛状根培养分离得到的黄芪甲苷。 | |||
T3808 |
Icariside I
淫羊藿次苷I,Lcariside I,Icariin I,Icarisid I |
Others | Others |
Icariside I (Lcariside I) 是一种 Icarlin 的代谢产物,具有调节骨重塑的作用,可用于研究骨质疏松。 | |||
T3924 |
Astragaloside II
黄芪皂苷 II,Astrasieversianin VIII |
TGF-beta/Smad | Stem Cells |
Astragaloside II (Astrasieversianin VIII) 是一种分离自黄芪中的天然化合物。 | |||
T3925 |
Astragaloside I
黄芪皂苷I,Cyclosieversioside B,Astrasieversianin IV |
Wnt/beta-catenin | Cytoskeletal Signaling; Stem Cells |
Astragaloside I (Cyclosieversioside B) 是从黄芪中分离得到天然产物。它可通过 Wnt/β-catenin 信号通路刺激成骨细胞分化,可用于成骨活性研究。 | |||
T6S1966 |
Curculigoside
Curculigoside A,仙茅苷 |
Antioxidant; NF-κB; JAK; STAT | Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; NF-κB; oxidation-reduction; Stem Cells |
Curculigoside (Curculigoside A) 是仙茅中的主要皂苷,具有显著的抗氧化、抗骨质疏松、抗抑郁和神经保护作用。它通过调节JAK/STAT/NF-κB 信号传导途径,具有抗关节炎作用。 | |||
TN6568 |
Glycinol
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Glycinol enhances osteogenic differentiation and attenuates the effects of age on mesenchymal stem cells, it could as a potential preventive or treatment for osteoporosis. Glycinol also has antidiuretic activity. | |||
TN3215 |
7,4'-Dihydroxy-8-methylflavan
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Others | Others |
7,4'-Dihydroxy-8-methylflavan can significantly promote mesenchymal stem cells (MSCs) osteogenic differentiation by increasing the levels of alkaline phosphatase (ALP) activity. 7,4'-Dihydroxy-8-methylflavan also has free radical scavenging properties. | |||
T14368 |
Azadirachtin B
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Others | Others |
Azadirachtin B, a limonoid derived from the seed kernels of Azadirachta indica, exhibits a broad spectrum of biochemical activities, including insecticidal, nematocidal, anticancer, anti-inflammatory, antiviral, and osteogenic effects. It is effective against the Epstein-Barr virus early antigen (EBV-EA), enhances alkaline phosphatase (ALP) activity, and promotes osteoblast differentiation[1][2][3]. | |||
TN4999 |
Serratenediol
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BCL; PARP; Caspase | Apoptosis; Chromatin/Epigenetic; DNA Damage/DNA Repair; Proteases/Proteasome |
Serratenediol demonstrates strong inhibitory effects on the Epstein-Barr virus early antigen (EBV-EA) activation without showing any cytotoxicity, its effects being stronger than that of a representative control, oleanolic acid. Serratenediol can promote |
Cat. No. | Product Name | Species | Expression System |
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TMPH-01019 |
BMP-7 Protein, Human, Recombinant (GST)
BMP-7,OP1,BMP7,OP-1,Bone morphogenetic protein 7,Osteoge... |
Human | E. coli |
BMP-7 Protein, Human, Recombinant (GST) is expressed in E. coli expression system with N-GST tag. The predicted molecular weight is 42.7 kDa and the accession number is P18075. | |||
TMPJ-01473 |
BMP-7 Protein, Human, Recombinant
Eptotermin alfa,OP-1,OP1,Osteogenic protein 1,Bone ... |
Human | HEK293 Cells |
Bone morphogenetic protein 7 (BMP7), also known as osteogenic protein-1 (OP-1) is a member of Transforming growth factor-β (TGF-β) family of proteins. Bone morphogenetic proteins were discovered in 1965 by Marshal Urist, of which BMP7 is of particular interest in this review being a leptin-independent anorexinogen and having role in energy expenditure in the brown adipose tissue, which makes it a potential target for preventing/treating obesity. As it has been established that Obesity displays a... | |||
TMPK-00678 |
CALCA/CGRP Protein, Mouse, Recombinant (hFc)
CGRP,Katacalcin,PDN-21,CGRP-I,CGRP1,Calcitonin 1,Calcitonin,... |
Mouse | HEK293 Cells |
Specific fragments of methylation changes in the target gene (Calca) were identified by IGV analysis. CGRP was applied to compare the effects on ASCs-T2DM morphology via phalloidin staining, proliferation through CCK-8 assay, and osteogenic differentiation with osteogenic staining, qPCR, and repair of calvarial defect. Furthermore, 5-azacytidine (5-az) was used to intervene ASCs-T2DM to verify the relationship between the methylation level of the target fragment and expression of Calca. | |||
TMPJ-01465 |
GM-CSF/CSF2 Protein, Human, Recombinant (E. coli)
Colony-Stimulating Factor,CSF2,CSF,Sargramostim,集落刺激因子,Molgr... |
Human | E. coli |
Granulocyte-Macrophage Colony Stimulating Factor (GM-CSF) was initially characterized as a growth factor that can support the in vitro colony formation of granulocyte-macrophage progenitors. It is produced by a number of different cell types (including activated T cells, B cells, macrophages, mast cells, endothelial cells and fibroblasts) in response to cytokine of immune and inflammatory stimuli. Besides granulocyte-macrophage progenitors, GM-CSF is also a growth factor for erythroid, megakaryo... | |||
TMPH-02552 |
BMP3 Protein, Mouse, Recombinant (Myc)
Bone morphogenetic protein 3,Bmp3,BMP-3 |
Mouse | E. coli |
Negatively regulates bone density. Antagonizes the ability of certain osteogenic BMPs to induce osteoprogenitor differentitation and ossification. | |||
TMPJ-00338 |
LRRC15 Protein, Human, Recombinant (His & Avi), Biotinylated
Leucine-rich repeat-containing protein 15,LIB,LRRC15,Leucine... |
Human | HEK293 Cells |
The type I transmembrane protein 15-leucine-rich repeat containing membrane protein (LRRC15) is a member of the LRR superfamily. The LRR family is a structural module for protein-protein and protein-matrix interactions used for molecular recognition process such as cell adhesion, signal transduction, DNA repair, and RNA processing. The LRRC15 is also a transmembrane protein demonstrated to play important roles in cancer. LRRC15 expression was notably increased 4.6-fold in cariesdiseased pulpal t... | |||
TMPJ-01245 |
UCMA Protein, Human, Recombinant
UCMA,Unique cartilage matrix-associated protein,Gla-rich pro... |
Human | E. coli |
C10orf49 is a secreted protein which encoded by the UCMA gene. It is a member of the UCMA family. C10orf49 is predominantly expressed in resting chondrocytes. It may be involved in the negative control of osteogenic differentiation of osteochondrogenic precursor cells in peripheral zones of fetal cartilage and at the cartilage-bone interface. | |||
TMPH-01015 |
BMP-3 Protein, Human, Recombinant (His)
BMP3A,Bone morphogenetic protein 3A,BMP3,Osteogenin,Bone mor... |
Human | E. coli |
Growth factor of the TGF-beta superfamily that plays an essential role in developmental process by inducing and patterning early skeletal formation and by negatively regulating bone density. Antagonizes the ability of certain osteogenic BMPs to induce osteoprogenitor differentitation and ossification. Initiates signaling cascades by associating with type II receptor ACVR2B to activate SMAD2-dependent and SMAD-independent signaling cascades including TAK1 and JNK pathways. BMP-3 Protein, Human, R... | |||
TMPY-01783 |
SMOC1 Protein, Human, Recombinant (His)
OAS,SPARC related modular calcium binding 1 |
Human | HEK293 Cells |
SPARC-related modular calcium-binding protein 1, also known as secreted modular calcium-binding protein 1 and SMOC1, is a member of the SPARC family. SMOC1 is widely expressed in many tissues with a strongest signal in ovary. It contains two EF-hand domains, one Kazal-like domain and two thyroglobulin type-1 domains. Extracellular matrix proteins have been implicated in the regulation of osteoblast differentiation of bone marrow-derived mesenchymal stem cells (BMSCs) through paracrine or autocri... | |||
TMPJ-00521 |
CHL2 Protein, Mouse, Recombinant (His)
CHRDL2,chordin-like 2,chordin-like protein 2,BNF-1 |
Mouse | HEK293 Cells |
Mouse Chordin-Like 2, also known as CHL2, is a novel chordin family member with structural homology to CHL1 which is implicated in tumor angiogenesis. The mouse CHL2 gene encodes a 426 amino acids (aa) protein with a 25 aa signal peptide. The mature chain of CHL2 protein contains two potential N-linked glycosylation sites, one putative NLS and three 63 aa cysteine-rich von Willebrand type C repeats (CRs). CHL2 gene is weakly expressed in the liver and kidney, partly expressed in the connective ... | |||
TMPH-02613 |
ATF-5 Protein, Mouse, Recombinant (His & Myc)
Transcription factor ATFx,Transcription factor-like protein ... |
Mouse | E. coli |
Transcription factor that either stimulates or represses gene transcription through binding of different DNA regulatory elements such as cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), ATF5-specific response element (ARE) (consensus: 5'-C[CT]TCT[CT]CCTT[AT]-3') but also the amino acid response element (AARE), present in many viral and cellular promoters. Critically involved, often in a cell type-dependent manner, in cell survival, proliferation, and differentiation. Its transcrip... |