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Search Results for " mesenchymal stem cells "

Targets Recommended: TGF-beta/Smad

13

抑制剂 & 化合物

8

天然产物

9

重组蛋白

1

同位素标记化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T1748	Kartogenin KGN	TGF-beta/Smad	Stem Cells
	Kartogenin (KGN) 是一种人间充质干细胞分化为软骨细胞的诱导剂(EC50:100 nM)。它能够结合纤维蛋白 A，破坏其与转录因子核心结合因子 β 亚基 (CBFβ) 的相互作用，并通过调节 CBFβ-RUNX1 转录程序，诱导软骨形成，可用于研究骨关节炎。
T21981	Phthalazinone pyrazole	Aurora Kinase	Cell Cycle/Checkpoint; Chromatin/Epigenetic
	Phthalazinone pyrazole 是强效、选择性和口服生物可利用的 Aurora-A 激酶抑制剂，IC50值为 0.031 μM。它抑制人胚胎干细胞向肝细胞样细胞分化过程中的上皮间质转化。它还可阻止有丝分裂并随后通过增殖细胞的凋亡抑制肿瘤生长。
T1725	Y-27632 dihydrochloride 反式-4-[(R)-1-氨基乙基]-N-(4-吡啶基)环己烷甲酰胺二盐酸盐,Y-27632 2HCl	ROCK; Apoptosis	Apoptosis; Cell Cycle/Checkpoint; Cytoskeletal Signaling; Stem Cells
	Y-27632 dihydrochloride (Y-27632 2HCl) 是一种 ROCK-I 和 ROCK-II 抑制剂，具有口服有效性、ATP 竞争性。Y-27632 dihydrochloride 还抑制分离诱导的小鼠前列腺干或祖细胞凋亡。
T8400	Pamidronic acid	Wnt/beta-catenin	Cytoskeletal Signaling; Stem Cells
	Pamidronic acid 可用于各种骨吸收类疾病的研究。
T23446	TCS 2210	Others	Others
	TCS 2210是间充质干细胞中神经元分化的诱导剂，并增加神经元标志物β-III 管蛋白的表达和神经元特异性烯醇酶的表达。
T22814	GSA-10	Hedgehog/Smoothened	GPCR/G Protein; Stem Cells
	GSA-10是新型的喹啉甲酰胺衍生物，有效激动平滑受体剂，EC50为 1.2 μM。它作用于Smo，促进多能间充质干细胞分化为成骨细胞。它介导 Hedgehog 信号传导，这可能对癌症疾病的再生医学具有研究意义。
T77701	FL118 FL 118,FL-118,10,11-(Methylenedioxy)-20(S)-camptothecin	Survivin	Apoptosis
	FL118是一种新型存活素抑制剂，可抑制癌症干细胞样特性。FL118 是一种新型喜树碱类似物，具有抗癌活性，通过 Wnt/β-catenin 信号通路抑制上皮-间充质转化，从而抑制人乳腺癌细胞的迁移和侵袭。
T31124	CW 008 CW-008,CW008	Others	Others
	CW 008 is an activator of the cAMP/PKA/CREB pathway. It promotes osteogenic differentiation of human bone marrow derived mesenchymal stem cells in vitro and increases bone mass and bone volume density in ovariectomized mice.
T61417	PPARγ agonist 7	Others	Others
	PPARγ agonist 7 (Compound 3a) is a highly potent and selective agonist of the peroxisome proliferator-activated receptor gamma (PPARγ). It specifically stimulates adiponectin production in human bone marrow mesenchymal stem cells (hBM-MSCs), making it an innovative full agonist of PPARγ with an EC 50 value of 4.34 μM [1].
T60792	NMDA receptor antagonist-3	Others	Others
	NMDA receptor antagonist-3 是NMDA 受体的拮抗剂。NMDA receptor antagonist-3 在 SH-SY5Y 和人脂肪间充质干细胞中具有显著的回收率（40.0 %，100 μM）和安全的毒理学特性。
T39531	RAD16-I hydrochloride RAD16-I hydrochloride
	RAD16-I hydrochloride is a self-assembling peptide with nanofibrous morphology that provides an optimal microenvironment for the proliferation and differentiation of human mesenchymal stem cells (hMSC) into chondrocytes. This peptide, known as RAD16-I, has been extensively studied and serves as a model to assess the amyloid-like staining properties of self-assembling peptide nanofibers (SAPNFs).
T36497	CAY10735 CAY10735	Others	Others
	CAY10735 is an anticancer compound.1 It inhibits proliferation in a panel of melanoma and breast, pancreatic, and lung cancer cell lines (IC50s = 0.674-11.56 μM). CAY10735 inhibits migration of and the epithelial-to-mesenchymal transition (EMT) in A375 and B16/F10 melanoma cells in vitro in a concentration-dependent manner. It reduces the viability of spheroid A375 and B16/F10 cells (IC50s = 3.04 and 1.24 μM, respectively) and increases production of reactive oxygen species (ROS) in these cells ...
T36460	CAY10736 CAY10736	Others	Others
	CAY10736 is an anticancer compound.1 It inhibits proliferation in a panel of melanoma and breast, pancreatic, and lung cancer cell lines (IC50s = 0.827-9.89 μM). CAY10736 inhibits migration and epithelial-to-mesenchymal transition (EMT) of A375 and B16/F10 melanoma cells in vitro in a concentration-dependent manner. It reduces the viability of spheroid A375 and B16/F10 cells (IC50s = 2.4 and 1.59 μM, respectively) and increases the production of reactive oxygen species (ROS) in these cells in a ...

化合物

Cat.No: T1748

Synonym: KGN

Target: TGF-beta/Smad

Phthalazinone pyrazole

Cat.No: T21981

Target: Aurora Kinase

Y-27632 dihydrochloride

Cat.No: T1725

Synonym: 反式-4-[(R)-1-氨基乙基]-N-(4-吡啶基)环己烷甲酰胺二盐酸盐,Y-27632 2HCl

Target: ROCK, Apoptosis

Pamidronic acid

Cat.No: T8400

Target: Wnt/beta-catenin

Cat.No: T23446

Target: Others

Cat.No: T22814

Target: Hedgehog/Smoothened

Cat.No: T77701

Synonym: FL 118,FL-118,10,11-(Methylenedioxy)-20(S)-camptothecin

Target: Survivin

Cat.No: T31124

Synonym: CW-008,CW008

Target: Others

PPARγ agonist 7

Cat.No: T61417

Target: Others

NMDA receptor antagonist-3

Cat.No: T60792

Target: Others

RAD16-I hydrochloride

Cat.No: T39531

Synonym: RAD16-I hydrochloride

Cat.No: T36497

Synonym: CAY10735

Target: Others

Cat.No: T36460

Synonym: CAY10736

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
TN7036	N-(3-Methoxybenzyl)-(9Z,12Z,15Z)-octadecatrienamide (9Z,12Z,15Z)-N-[(3-Methoxyphenyl)methyl]-9,12,15-octadecatrienamide,间-甲氧基苄基-亚麻酰胺,Macamide Impurity 14	Wnt/beta-catenin	Cytoskeletal Signaling; Stem Cells
	N-(3-Methoxybenzyl)-(9Z,12Z,15Z)-octadecatrienamide (Macamide Impurity 14) 是一种从玛卡中分离得到的玛卡酰胺。它能够激活典型的Wnt/β‐catenin 信号通路，诱导间充质干细胞成骨分化和随后的骨形成，可用于研究骨质疏松症。
TN2081	Maohuoside A	MAPK	MAPK
	Maohuoside A 是从 E. koreanum 中分离出的单一化合物，具有促进成骨作用。它能够利用 MAPK 信号通路骨及形态发生蛋白 (BMP) ，促进骨髓间充质干细胞的成骨作用。
T3S2312	Poncirin 枸橘苷,Isosakuranetin-7-neohesperidoside	Apoptosis; Others	Apoptosis; Others
	Poncirin (Isosakuranetin-7-neohesperidoside) 是从三叶草中分离出来的一种天然产物，具有抗炎活性。它防止脂肪生成，增强间充质干细胞中的成骨细胞分化，增加骨矿物质密度，改善小梁微结构，可能反映 GIO 小鼠的骨形成增加和骨吸收减少。
T4915	β-Glycerophosphate disodium salt hydrate	Phosphatase; Endogenous Metabolite	Metabolism
	β-Glycerophosphate disodium salt hydrate 是一种磷酸酶抑制剂，是内源性代谢产物的一种。
TL0008	Gigantol	Wnt/beta-catenin; Glucosidase	Cytoskeletal Signaling; Metabolism; Stem Cells
	Gigantol 是一种联苄基化合物，从几种药用兰花中获得，是一种Wnt/β-catenin 通路抑制剂，具有抗肿瘤活性。
TN4082	Friedelin 3,4-lactone	Others	Others
	Friedelin-3,4-lactone has a promotion effect on the inducing proliferation of rat mesenchymal stem cells(rMSCs).
TN6568	Glycinol
	Glycinol enhances osteogenic differentiation and attenuates the effects of age on mesenchymal stem cells, it could as a potential preventive or treatment for osteoporosis. Glycinol also has antidiuretic activity.
TN3215	7,4'-Dihydroxy-8-methylflavan	Others	Others
	7,4'-Dihydroxy-8-methylflavan can significantly promote mesenchymal stem cells (MSCs) osteogenic differentiation by increasing the levels of alkaline phosphatase (ALP) activity. 7,4'-Dihydroxy-8-methylflavan also has free radical scavenging properties.

天然产物

N-(3-Methoxybenzyl)-(9Z,12Z,15Z)-octadecatrienamide

Cat.No: TN7036

Synonym: (9Z,12Z,15Z)-N-[(3-Methoxyphenyl)methyl]-9,12,15-octadecatrienamide,间-甲氧基苄基-亚麻酰胺,Macamide Impurity 14

Target: Wnt/beta-catenin

Cat.No: TN2081

Target: MAPK

Cat.No: T3S2312

Synonym: 枸橘苷,Isosakuranetin-7-neohesperidoside

Target: Apoptosis, Others

β-Glycerophosphate disodium salt hydrate

Cat.No: T4915

Target: Phosphatase, Endogenous Metabolite

Cat.No: TL0008

Target: Wnt/beta-catenin, Glucosidase

Friedelin 3,4-lactone

Cat.No: TN4082

Target: Others

Cat.No: TN6568

7,4'-Dihydroxy-8-methylflavan

Cat.No: TN3215

Target: Others

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-05004	FGF-4 Protein, Human, Recombinant HST-1,KFGF,fibroblast growth factor 4,HSTF1,K-FGF,HST,HBGF-4	Human	E. coli
	FGF (fibroblast growth factor) signalling is known to be required for many aspects of mesoderm formation and patterning during Xenopus development and has been implicated in regulating genes required for the specification of both blood and skeletal muscle lineages. Fibroblast growth factor 4 (FGF4) signaling induces differentiation from embryonic stem cells (ESCs) via the phosphorylation of downstream molecules such as mitogen-activated protein kinase/extracellular signal-related kinase (MEK) a...
TMPY-00021	PADI4 Protein, Human, Recombinant (His) PADI5,PAD4,PDI4,peptidyl arginine deiminase, type IV,PAD,PDI...	Human	Baculovirus Insect Cells
	Protein-arginine deiminase type-4, also known as HL-6 PAD, Peptidylarginine deiminase IV, Protein-arginine deiminase type I V and PADI4, is a cytoplasm and nucleus protein that belongs to the protein arginine deiminase family. PADI4 is expressed in CD34+stem cells in normal tissues, and many more CD34+ cells expressing PADI4 are present in tumour tissues. PADI4 post-translationally converts peptidylarginine to citrulline, a process called citrullination. Studies have demonstrated the high expres...
TMPJ-00253	OPG Protein, Mouse, Recombinant (His) Opg,Ocif,Tnfrsf11b,Osteoclastogenesis inhibitory factor,Oste...	Mouse	HEK293 Cells
	Osteoprotegerin (OPG, Tnfrsf11b) is a secreted protein that regulates bone density. OPG is widely expressed and constitutively released as a homodimer by mesenchymal stem cells, fibroblasts and endothelial cells. Regulation of its expression by estrogen, parathyroid hormone and cytokines is complex and changes with age. OPG acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis. TRAIL decreases the release of OPG from cells that express it, while OPG ...
TMPY-01783	SMOC1 Protein, Human, Recombinant (His) OAS,SPARC related modular calcium binding 1	Human	HEK293 Cells
	SPARC-related modular calcium-binding protein 1, also known as secreted modular calcium-binding protein 1 and SMOC1, is a member of the SPARC family. SMOC1 is widely expressed in many tissues with a strongest signal in ovary. It contains two EF-hand domains, one Kazal-like domain and two thyroglobulin type-1 domains. Extracellular matrix proteins have been implicated in the regulation of osteoblast differentiation of bone marrow-derived mesenchymal stem cells (BMSCs) through paracrine or autocri...
TMPY-04403	NLK/Nemo Like Kinase Protein, Human, Recombinant (His & GST) nemo-like kinase,LAK1	Human	Baculovirus Insect Cells
	Nemo-like kinase contains 1 protein kinase domain and belongs to the protein kinase superfamily, CMGC Ser/Thr protein kinase family, and MAP kinase subfamily. It also contains a TQE activation loop motif in which autophosphorylation of the threonine residue (Thr-298) is sufficient for kinase activation. As a serine/threonine-protein kinase, Nemo-like kinase regulates some transcription factors with key roles in cell fate determination. It is a positive effector of the non-canonical Wnt signaling...
TMPY-04389	MAP3K8 Protein, Human, Recombinant (GST) TPL2,MEKK8,EST,ESTF,COT,Tpl-2,c-COT,AURA2,mitogen-activated ...	Human	Baculovirus Insect Cells
	Mitogen-activated protein kinase kinase kinase 8, also known as Cancer Osaka thyroid oncogene, Proto-oncogene c-Cot, Serine/threonine-protein kinase cot, Tumor progression locus 2 and MAP3K8, is a cytoplasm protein that belongs to the protein kinase superfamily, STE Ser/Thr protein kinase family and MAP kinase kinase kinase subfamily. MAP3K8 is expressed in several normal tissues and human tumor-derived cell lines. Isoform 1 of MAP3K8 is activated specifically during the S and G2/M phases of the...
TMPY-04534	GDF-8 Protein, Mouse, Recombinant (hFc) 骨肉瘤源生长因子,Cmpt,myostatin,Gdf8	Mouse	HEK293 Cells
	GDF-8 / Myostatin / MSTN is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. GDF-8 / Myostatin / MSTN is highly expressed in skeletal muscle, and myostatin loss-of-function le...
TMPH-02217	SMARCA4 Protein, Human, Recombinant (His) Transcription activator BRG1,Protein brahma homolog 1,SWI/SN...	Human	P. pastoris (Yeast)
	Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating the calcium-dependent release of a repressor compl...
TMPY-01576	Artemin Protein, Mouse, Recombinant (hFc) artemin,neublastin	Mouse	HEK293 Cells
	Artemin (ARTN) is a member of glial cell line-derived neurotrophic factor (GDNF) family of ligands, and its signaling is mediated via a multi-component receptor complex including the glycosylphosphatidylinositol-anchored GDNF family receptors a (GFRa1, GFRa3) and RET receptor tyrosine kinase. The major mechanism of ARTN action is via binding to a non-signaling co-receptor. The major function of ARTN is to drive the molecule to induce migration and axonal projection from sympathetic neurons. It a...

重组蛋白

FGF-4 Protein, Human, Recombinant

Cat.No: TMPY-05004

Species: Human

Expression System: E. coli

PADI4 Protein, Human, Recombinant (His)

Cat.No: TMPY-00021

Species: Human

Expression System: Baculovirus Insect Cells

OPG Protein, Mouse, Recombinant (His)

Cat.No: TMPJ-00253

Species: Mouse

Expression System: HEK293 Cells

SMOC1 Protein, Human, Recombinant (His)

Cat.No: TMPY-01783

Species: Human

Expression System: HEK293 Cells

NLK/Nemo Like Kinase Protein, Human, Recombinant (His & GST)

Cat.No: TMPY-04403

Species: Human

Expression System: Baculovirus Insect Cells

MAP3K8 Protein, Human, Recombinant (GST)

Cat.No: TMPY-04389

Species: Human

Expression System: Baculovirus Insect Cells

GDF-8 Protein, Mouse, Recombinant (hFc)

Cat.No: TMPY-04534

Species: Mouse

Expression System: HEK293 Cells

SMARCA4 Protein, Human, Recombinant (His)

Cat.No: TMPH-02217

Species: Human

Expression System: P. pastoris (Yeast)

Artemin Protein, Mouse, Recombinant (hFc)

Cat.No: TMPY-01576

Species: Mouse

Expression System: HEK293 Cells

Cat. No.	Product Name	Target	Signaling Pathways
T35513	13C15-Nivalenol 13C15-Nivalenol
	13C15-Nivalenol is intended for use as an internal standard for the quantification of nivalenol by GC- or LC-MS. Nivalenol is a trichothecene mycotoxin that has been found inFusarium.1It is lethal to mice (LD50= 6.9 mg/kg).2Nivalenol (5, 10, and 15 mg/kg) also induces thymic, splenic, and Peyer's patch cell apoptosis in mice.3 1.Yang, Z., Concannon, J., Ng, K.S., et al.Tetrandrine identified in a small molecule screen to activate mesenchymal stem cells for enhanced immunomodulationSci. Rep.63026...

同位素标记化合物

13C15-Nivalenol

Cat.No: T35513

Synonym: 13C15-Nivalenol

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