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Search Results for " marrow "

Targets Recommended: Dehydrogenase

67

抑制剂 & 化合物

12

天然产物

3

化合物库

80

重组蛋白

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Cat. No.	Product Name
L8400	血液病分子库		514 compounds
	514 种造血系统疾病相关的生物活性小分子化合物的特有集合，用于高通量、高内涵筛选；
L9810	抗纤维化化合物库		1180 compounds
	1180 种潜在的抗纤维化分子，是研究纤维化的有效工具，可以用于高通量筛选和高内涵筛选；
L8000	干细胞分化化合物库		1197 compounds
	1197 种干细胞分化信号通路相关的生物活性小分子化合物的特有集合，可用于高通量、高内涵筛选；

化合物库

血液病分子库

Cat.No: L8400

Compounds: 514

抗纤维化化合物库

Cat.No: L9810

Compounds: 1180

干细胞分化化合物库

Cat.No: L8000

Compounds: 1197

Cat. No.	Product Name	Target	Signaling Pathways
T2121	SW033291	Dehydrogenase	Metabolism
	SW033291 是有效的15-PGDH 抑制剂，与15-PGDH 亲和力高，Ki 为 0.1 nM。它增加骨髓和其他组织中前列腺素 PGE2 的水平。它还可促进组织再生。
T8645	PF-06446846	Others	Others
	PF-06446846 是口服有活性的 PCSK9抑制剂。它能够在密码子区域附近阻断 80S ribosome，选择性地直接抑制 PCSK9 的翻译。
T8550	NDMC101	Others; NF-κB; Proteasome	NF-κB; Others; Proteases/Proteasome; Ubiquitination
	NDMC101 是有效的破骨细胞形成抑制剂，通过下调 NFATc1 调控基因表达抑制破骨细胞分化。它与 DPP4底物相似，通过抑制DPP4抑制早期 T 细胞激活。它能够用于骨疾病的研究，如类风湿关节炎、滑膜炎等。
T9026	MEISi-2 Benzoic acid, 4-hydroxy-, 2-[(Z)-(2-oxo-1(2H)-naphthalenylidene)methyl]hydrazide	Others	Others
	MEISi-2 是 MEIS（造血干细胞自我更新的关键调控因子）选择性抑制剂。它可用于心脏损伤、造血问题、骨髓移植和癌症的研究。
T9603	MNITMT	Others	Others
	MNITMT 是一种有效的免疫抑制剂 (immunosuppressive agent)，没有骨髓毒性。
T8400	Pamidronic acid	Wnt/beta-catenin	Cytoskeletal Signaling; Stem Cells
	Pamidronic acid 可用于各种骨吸收类疾病的研究。
T26828	BIT225 BIT 225,BIT-225	Antiviral	Immunology/Inflammation
	BIT225 是一种人类免疫缺陷病毒 1 型 Vpu 抑制剂，具有抗病毒活性，可抑制骨髓树突状细胞中的 HIV-1 复制，抑制 HIV-1 Vpu 形成的离子通道。
T25705	Imupedone LF1695,LF-1695,LF 1695	Others	Others
	Imupedone (LF 1695) 是一种合成免疫调节剂，可调节 T 淋巴细胞和巨噬细胞，诱导骨髓前体细胞的 T 细胞分化，增加淋巴细胞对有丝分裂原、抗原和同种异体细胞的增殖反应。
T1199	Mitotane Mitotan,o,p'-DDD,NCI-C04933,2,4′-DDD,米托坦	Apoptosis; AChR	Apoptosis; Neuroscience
	Mitotane (NCI-C04933) 是 DDD 的同分异构体和 DDT 的衍生物，可作用于肾上腺皮质癌，有抗癌活性。
T9089	FTO-IN-1 UUN44923	Others	Others
	UUN44923 是脂肪及肥胖相关酶(FTO) 抑制剂(IC50<1 μM)。其中FTO-IN-1 (UUN44923) 可用于研究癌症。
T1776L	Plerixafor octahydrochloride 盐酸普乐沙福,JM3100 octahydrochloride,Plerixafor 8HCl (AMD3100 8HCl),Plerixafor 8HCl,SID791 octahydrochloride,AMD 3100 octahydrochloride,JM 3100 8HCl	Virus Protease; HIV Protease; CXCR	Autophagy; GPCR/G Protein; Immunology/Inflammation; Microbiology/Virology; Proteases/Proteasome
	Plerixafor octahydrochloride (JM3100 octahydrochloride) 是一种选择性的CXCR4拮抗剂，IC50为 44 nM。Plerixafor 是一种具有造血干细胞动员活性的双环霉素。
T76699	Sabatolimab MBG453,NVP-MBG453	Others	Others
	Sabatolimab (MBG453) 是一种靶向 TIM-3的人源化 IgG4 (S228P) 抗体，是一种有效的调节适应性和先天免疫反应的抑制性受体。Sabatolimab 具有潜在的免疫抑制活性，可选择性与免疫细胞和骨髓细胞上的 TIM-3 结合。
T14692	BMX-IN-1 BMX kinase inhibitor	BTK	Angiogenesis; Tyrosine Kinase/Adaptors
	BMX-IN-1 (BMX kinase inhibitor) 是 X 染色体上的骨髓酪氨酸激酶 (BMX, IC50 = 8 nM) 和相关的布鲁顿酪氨酸激酶 (BTK, IC50 = 10.4 nM) 的特异性抑制剂，但 BMX-IN-1 对 Blk、JAK3、EGFR、Itk 或 Tec 活性的效力要低 47-656 倍以上。
TP1828	N-Acetyl-Ser-Asp-Lys-Pro	RAAS	Endocrinology/Hormones
	N-Acetyl-Ser-Asp-Lys-Pro 通过酶促处理胸腺素 β4 在骨髓细胞中形成。它抑制多能造血干细胞进入细胞周期的 S 期，并防止小鼠中的 Ara-C 致死性。
TP1820L	Osteogenic Growth Peptide, OGP acetate Osteogenic Growth Peptide, OGP acetate(132996-61-3 free base)	Others	Others
	Osteogenic Growth Peptide, OGP acetate(132996-61-3 free base) 是一种短的、天然存在的 14 聚体生长因子肽，存在于血清中，浓度为 μM。成骨生长肽 OGP 是局部骨髓损伤全身成骨反应机制的关键因素。
T4570	Pipobroman Vercyte,A-8103,Amedel,哌泊溴烷	Others; DNA Alkylator/Crosslinker	DNA Damage/DNA Repair; Others
	Pipobroman (Vercyte) 是一种烷基化剂，是哌嗪的溴化衍生物。它通过抑制 DNA 和 RNA 聚合酶或减少嘧啶核苷酸掺入 DNA 发挥其作用。它在真性红细胞增多症和原发性血小板增多症中具有良好的临床活性，可用于癌症研究。
T36944	Ara-G	Nucleoside Antimetabolite/Analog	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	Ara-G 是一种脱氧鸟苷 (GdR) 类似物和核苷类似物，可被 T 淋巴谱系细胞迅速转化为其相应的阿拉伯糖基鸟嘌呤核苷酸三磷酸 (araGTP)，从而抑制 DNA 合成和对 T 淋巴母细胞的选择性体外毒性细胞系以及来自 T 细胞急性淋巴细胞白血病 (ALL) 患者的新鲜分离的白血病细胞。
T25299	Degranol NSC 9698,NSC-9698,NSC9698	Others	Others
	Degranol is a nitrogen mustard derivative alkylating agent utilized as antineoplastic. It causes severe bone marrow depression and is a powerful vesicant.
T25816	Mitolactol NSC 104800,NSC-104800,NSC104800	Others	Others
	Mitolactol is an alkylating antineoplastic toxic to bone marrow; utilized in breast cancer, also in combination with other drugs. Mitolactol is able to cross bloodbrain barrier, consequently could control certain brain tumors.
TP2339	Goralatide
	Goralatide, isolated from fetal calf bone marrow, exerts a high inhibitory activity on the proliferation of hematopoietic pluripotent stem cells.
T71422	S6821	Others	Others
	S6821 is a TAS2R8 antagonist. S6821 was not found to be mutagenic or clastogenic in vitro, and did not induce micronuclei in bone marrow polychromatic erythrocytes in vivo.
T15135	Direct Black 38 C.I. 30235,Chlorazol Black E	Others	Others
	Direct Black 38 is an azo dye.It induces unscheduled DNA synthesis in liver and micronucleus in bone marrow of rats in vivo[1].
T25319	Diacetylsplenopentin HCl Diacetylsplenopentin hydrochloride	Others	Others
	Diacetylsplenopentin HCl is used as a synthetic immunomodulator that affects the proliferation and differentiation of bone marrow stem cells without stimulating pathological immune responses beyond the balance of the immune system. This effect is specific
T31124	CW 008 CW-008,CW008	Others	Others
	CW 008 is an activator of the cAMP/PKA/CREB pathway. It promotes osteogenic differentiation of human bone marrow derived mesenchymal stem cells in vitro and increases bone mass and bone volume density in ovariectomized mice.
T32009	GSK321 GSK 321,GSK-321	Others	Others
	GSK321 is an effective and selective IDH1 mutation inhibitor, which can effectively inhibit the production of 2-HG in HT-1080 cells, and induce IDH1 mutant cells to differentiate into bone marrow at the level of leukemia blasts and more stem cells.
T40908	KLD-12
	KLD-12, a 12-residue self-assembling peptide, displays properties that promote chondrogenic differentiation of bone marrow stromal cells (BMSCs). Moreover, KLD-12 hydrogel can effectively fill full-thickness osteochondral defects in their original location, leading to improved cartilage repair.
T71904	Chlormadinone (free base)	Others	Others
	Chlormadinone (free base) is a synthetic steroid hormone and antagonist at androgen and estrogen receptors used to treat BPH and polycystic ovary syndrome. It also promotes osteoblast differentiation and Ca deposition in bone marrow stem cells.
T27367	FR 900490 BMY 28700,FR-900490,FR900490	Others	Others
	FR 900490 is an immunoactive substance produced by a fungus Discosia sp. F-11809. In vitro FR-900490 restores the colony forming units in culture (cfu-c) in bone marrow cells, which were suppressed by immunosuppressive factor obtained from the serum of sa
TP1371	N-Acetyl-Ser-Asp-Lys-Pro TFA
	N-Acetyl-Ser-Asp-Lys-Pro (TFA) is an endogenous tetrapeptide that is naturally produced in the bone marrow. It serves as a specific substrate for the N-terminal site of ACE, the enzyme responsible for angiotensin converting activity.
T14374	AZD2906	Others	Others
	AZD2906, a selective glucocorticoid receptor (GR) agonist, demonstrates inhibitory concentrations (IC50s) of 2.2 nM in human GR, 0.3 nM in rat peripheral blood mononuclear cells (PBMC), 41.6 nM in human whole blood, and 7.5 nM in rat whole blood, respectively[1]. Additionally, it induces an increase in micronucleated immature erythrocytes within rat bone marrow.
TP1820	Osteogenic Growth Peptide, OGP
	Osteogenic Growth Peptide, OGP is a short, naturally occurring 14-mer growth factor peptide found in serum at μM concentrations. Osteogenic growth peptide OGP is a key factor in the mechanism of the systemic osteogenic response to local bone marrow injury
TP2340	Hemoregulatory peptide 5b hp 5B,Pglu-glu-asp-cys-lys-OH,Peedck,Glp-glu-asp-cys-lys-OH,SP1 Pentapeptide
	Hemoregulatory peptide 5b is a synthetic analog of granulocyte chalone which initially identified in extracts of rodent bone marrow and human leukocytes. Monomer inhibits both formations of GM-CFC colonies and cytotoxic drug-induced recruitment of murine
T82851	BMP2-derived peptide
	BMP2-derived peptide为BMP-2第73至92位氨基酸序列的功能性基序，具有促进骨髓基质细胞(BMSCs)成骨分化及骨再生的作用。
T61417	PPARγ agonist 7	Others	Others
	PPARγ agonist 7 (Compound 3a) is a highly potent and selective agonist of the peroxisome proliferator-activated receptor gamma (PPARγ). It specifically stimulates adiponectin production in human bone marrow mesenchymal stem cells (hBM-MSCs), making it an innovative full agonist of PPARγ with an EC 50 value of 4.34 μM [1].
T80932	Tritrpticin
	Tritrpticin是一种来源于猪骨髓的抗菌肽，对Aspergillus fumigatus和Candida albicans表现出抗菌活性，其最小抑菌浓度（MIC）分别为250和1000 μg/ml。
TP2193	Myelopeptide-2 (MP-2)	Others	Others
	Myelopeptide-2 (MP-2) with the sequence Leu-Val-Val-Tyr-Pro-Trp is originally isolated from the supernatant of porcine bone marrow cell culture and is able to restore the mitogen responsiveness of human T lymphocytes inhibited by conditioned medium from H
T78459	Leishman's stain
	Leishman's stain为外周血和骨髓涂片染色的关键试剂，染色结果呈淡蓝灰色至深蓝色（在油镜下观察）。
T36260	NR 7h	Others	Others
	Potent and selective p38α and p38β degrader (DC50 < 50 nM). Displays no significant degradation of p38γ, p38δ, JNK1/2 or ERK1/2. Inhibits phosphorylation of MK2 in UV-treated cancer cells and LPS-stimulated bone marrow-derived macrophages (BMDM). Exhibits similar effect to p38α gene knockout in BBL358 cells. Active in vivo.
T61554	CSF1R-IN-13	Others	Others
	CSF1R-IN-13 is a powerful CSF1R inhibitor with potential applications in researching cancer diseases [1]. CSF1R, also known as colony stimulating factor 1 receptor, is a critical growth factor that regulates various cell types, including bone marrow progenitor cells, monocytes, macrophages, and giants [1]. CSF1R-IN-13 shows promise in furthering our understanding of cancer-related disorders (WO2019134661A1, compound 32) [1].
T69288	CEP-7055	Others	Others
	CEP-18770 is an orally bioavailable synthetic P2 threonine boronic acid inhibitor of the chymotrypsin-like activity of the proteasome, with potential antineoplastic activity. Proteasome inhibitor CEP 18770 represses the proteasomal degradation of a variety of proteins, including inhibitory kappaBalpha (IkappaBalpha), resulting in the cytoplasmic sequestration of the transcription factor NF-kappaB; inhibition of NF-kappaB nuclear translocation and transcriptional up-regulation of a variety of cel...
TP1978	11R-VIVIT NFAT inhibitor, Cell Permeable
	NFAT inhibitor. Inhibits LPS or LPS plus IFN-γ-induced IL-12 p40, IL-12 p70, IL-23 and TNF secretion from bone marrow-derived macrophages (BMDMs). Also attenuates NO production and Nos2 mRNA expression in LPS-stimulated BMDMs. Improves symptoms in a mouse
T37907	DL 175	Others	Others
	Potent and selective GPR84 biased agonist (EC50 = 33 nM). Exhibits no significant activity in a panel of 168 other GPCRs. Exhibits bias for G protein signaling pathways. Induces morphological changes in primary murine bone marrow-derived macrophages (BMDMs) in a cellular impedance assay, and promotes phagocytosis by M1 polarized U937 cells. Induces migration of primary human monocytes, but has no effect on macrophage chemotaxis.
T69205	GGTI-2166	Others	Others
	GGTI-2166 is a geranylgeranyl transferase I inhibitor. GGTI-2166 inhibit the pOC formation induced by RANKL or TNF-alpha in cultures of both mouse marrow-derived macrophage-colony-stimulating factor (M-CSF) dependent monocytes (MD cells) and the mouse monocyte cell line RAW 264.7 (RAW cells). GGTI-2166 inhibited TRAP activity induced by RANKL or TNF-alpha in both cell cultures and prevented the incorporation of [3H]all-trans geranylgeraniol into prenylated proteins in RAW cells.
T60731	Mitobronitol	Others	Others
	Mitobronitol (Myelobromol; DBM) 是甘露醇的溴化类似物。Mitobronitol 是被归类为烷化剂的抗癌剂。Mitobronitol 具有骨髓抑制作用，可显著降低加速慢性粒细胞白血病异体骨髓移植的几种并发症的风险。
T9134	UNC5293	Others	Others
	UNC5293 是一种有效的、口服的、高度 MERTK 选择性的抑制剂 (Ki=190 pM)。UNC5293 抑制 MERTK (IC50=0.9 nM)，对 Axl、Tyro3 和 Flt3 更具选择性。UNC5293 表现出优异的小鼠药代动力学特性，并可以被用于骨髓白血病研究。
T9655	NBC 6	Others	Others
	NLRP3-IN-NBC6 是一种有效的选择性 NLRP3炎性小体抑制剂，IC50为574 nM，其作用独立于 Ca2+。NLRP3-IN-NBC6 抑制 Nigericin 诱导的 THP-1 细胞炎症反应和 Imiquimod 诱导的 LPS-primed 的骨髓源性巨噬细胞 (BMDMs) 释放 IL-1β。
T81171	SH491	Others	Others
	SH491（Compound 33）是一款抗骨质疏松药物。该化合物能够抑制RANKL诱导的骨髓源性单核细胞（BMM）分化为破骨细胞（IC50: 11.8 nM）。同时，SH491降低了破骨细胞形成的相关标记基因（TRAP、CTSK、MMP-9和ATPase v0d2）以及相应蛋白（TRAP、CTSK、MMP-9）的表达。
T78305	Briquilimab JSP-191
	Briquilimab (JSP-191) 是针对 CD117 (c-Kit) 的无毒人源化单克隆抗体，用于消耗造血干细胞 (HSC)。它被应用于重度联合免疫缺陷 (SCID) 治疗中，以清空宿主骨髓生态位，为供体造血干细胞移植及免疫重建创造条件。
T35587	Ganglioside GD1a mixture (sodium salt) Ganglioside B1	Others	Others
	Ganglioside GD1a is a sialic acid-containing glycosphingolipid found in brain, erythrocytes, bone marrow, testis, spleen, and liver. [1] It can be shed from the surface of tumor cells into the microenvironment where it influences tumor-host cell interactions to promote tumor cell proliferation, invasion, and metastasis. Ganglioside GD1a (20 μM) also increases endothelial cell proliferation. Furthermore, ganglioside GD1a has been shown to act as a functional coreceptor for toll-like receptor 2 (T...
T68497	FI-700	Others	Others
	FI-700 is a novel and potent FLT3 inhibitor with promising antileukemia activity. FI-700 showed a potent IC(50) value against FLT3 kinase at 20 nmol/L in an in vitro kinase assay. FI-700 showed selective growth inhibition against mutant FLT3-expressing leukemia cell lines and primary acute myeloid leukemia cells, whereas it did not affect the FLT3 ligand (FL)-driven growth of Wt-FLT3-expressing cells. Oral administration of FI-700 induced the regression of tumors in a s.c. tumor xenograft model ...

化合物

Cat.No: T2121

Target: Dehydrogenase

Cat.No: T8645

Target: Others

Cat.No: T8550

Target: Others, NF-κB, Proteasome

Cat.No: T9026

Synonym: Benzoic acid, 4-hydroxy-, 2-[(Z)-(2-oxo-1(2H)-naphthalenylidene)methyl]hydrazide

Target: Others

Cat.No: T9603

Target: Others

Pamidronic acid

Cat.No: T8400

Target: Wnt/beta-catenin

Cat.No: T26828

Synonym: BIT 225,BIT-225

Target: Antiviral

Cat.No: T25705

Synonym: LF1695,LF-1695,LF 1695

Target: Others

Cat.No: T1199

Synonym: Mitotan,o,p'-DDD,NCI-C04933,2,4′-DDD,米托坦

Target: Apoptosis, AChR

Cat.No: T9089

Synonym: UUN44923

Target: Others

Plerixafor octahydrochloride

Cat.No: T1776L

Synonym: 盐酸普乐沙福,JM3100 octahydrochloride,Plerixafor 8HCl (AMD3100 8HCl),Plerixafor 8HCl,SID791 octahydrochloride,AMD 3100 octahydrochloride,JM 3100 8HCl

Target: Virus Protease, HIV Protease, CXCR

Cat.No: T76699

Synonym: MBG453,NVP-MBG453

Target: Others

Cat.No: T14692

Synonym: BMX kinase inhibitor

Target: BTK

N-Acetyl-Ser-Asp-Lys-Pro

Cat.No: TP1828

Target: RAAS

Osteogenic Growth Peptide, OGP acetate

Cat.No: TP1820L

Synonym: Osteogenic Growth Peptide, OGP acetate(132996-61-3 free base)

Target: Others

Cat.No: T4570

Synonym: Vercyte,A-8103,Amedel,哌泊溴烷

Target: Others, DNA Alkylator/Crosslinker

Cat.No: T36944

Target: Nucleoside Antimetabolite/Analog

Cat.No: T25299

Synonym: NSC 9698,NSC-9698,NSC9698

Target: Others

Cat.No: T25816

Synonym: NSC 104800,NSC-104800,NSC104800

Target: Others

Cat.No: TP2339

Cat.No: T71422

Target: Others

Direct Black 38

Cat.No: T15135

Synonym: C.I. 30235,Chlorazol Black E

Target: Others

Diacetylsplenopentin HCl

Cat.No: T25319

Synonym: Diacetylsplenopentin hydrochloride

Target: Others

Cat.No: T31124

Synonym: CW-008,CW008

Target: Others

Cat.No: T32009

Synonym: GSK 321,GSK-321

Target: Others

Cat.No: T40908

Chlormadinone (free base)

Cat.No: T71904

Target: Others

Cat.No: T27367

Synonym: BMY 28700,FR-900490,FR900490

Target: Others

N-Acetyl-Ser-Asp-Lys-Pro TFA

Cat.No: TP1371

Cat.No: T14374

Target: Others

Osteogenic Growth Peptide, OGP

Cat.No: TP1820

Hemoregulatory peptide 5b

Cat.No: TP2340

Synonym: hp 5B,Pglu-glu-asp-cys-lys-OH,Peedck,Glp-glu-asp-cys-lys-OH,SP1 Pentapeptide

BMP2-derived peptide

Cat.No: T82851

PPARγ agonist 7

Cat.No: T61417

Target: Others

Cat.No: T80932

Myelopeptide-2 (MP-2)

Cat.No: TP2193

Target: Others

Leishman's stain

Cat.No: T78459

Cat.No: T36260

Target: Others

Cat.No: T61554

Target: Others

Cat.No: T69288

Target: Others

Cat.No: TP1978

Synonym: NFAT inhibitor, Cell Permeable

Cat.No: T37907

Target: Others

Cat.No: T69205

Target: Others

Cat.No: T60731

Target: Others

Cat.No: T9134

Target: Others

Cat.No: T9655

Target: Others

Cat.No: T81171

Target: Others

Cat.No: T78305

Synonym: JSP-191

Ganglioside GD1a mixture (sodium salt)

Cat.No: T35587

Synonym: Ganglioside B1

Target: Others

Cat.No: T68497

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T5751	Tigogenin	Others	Others
	Tigogenin 是甾体皂甙元，普遍用于甾体类药物的合成。它能够阻碍小鼠骨髓基质细胞脂肪细胞分化，促使成骨细胞的分化。
T3004	Batilol 鲨肝醇,Batilolum,Stearyl monoglyceride,Batyl alcohol,1-O-Octadecylglycerol	Others; Endogenous Metabolite	Metabolism; Others
	Batilol (Stearyl monoglyceride) 是内源性代谢产物的一种。
TN3209	3′,4′,7-Trihydroxyflavone	ATPase; Others; p38 MAPK; NF-κB	MAPK; Membrane transporter/Ion channel; NF-κB; Others
	3',4',7-Trihydroxyflavone 是分离自蚕豆荚的黄酮苷元化合物。
T2820	Glycitin 黄豆黄苷,Glycitein-7-β-O-glucoside,Glycitein 7-O-β-glucoside	Others; Influenza Virus; Antibacterial	Microbiology/Virology; Others
	Glycitin (Glycitein 7-O-β-glucoside) 是一种从豆类中分离出来的天然异黄酮，有抗菌，抗病毒和雌激素作用，还有促进骨髓基质细胞和成骨细胞的增殖和抑制骨转换的生物学功能。
T3674	Hydroxysafflor yellow A 藏红花,羟基红花黄色素A,HSYA,Safflomin A	TGF-beta/Smad	Stem Cells
	Hydroxysafflor yellow A (Safflomin A) 是一种黄酮类天然产物，从中药红花中分离得到，具有抗癌作用。
TN2143	3,7,4'-Trihydroxyflavone Resokaempferol,5-Deoxykampferol	DNA	DNA Damage/DNA Repair
	3,7,4'-Trihydroxyflavone(5-Deoxykampferol) 是从黄檀心材中分离得到的一种具有 DNA 断链活性的黄酮类化合物，可抑制 NF-κB 配体（RANKL）受体激活剂诱导的 RAW 264.7 细胞和骨髓巨噬细胞中的破骨细胞分化、肌动蛋白环形成和骨吸收。
T1257	Bestatin Ubenimex,乌苯美司	Others; Aminopeptidase; Antibacterial; Antibiotic; LTR	Immunology/Inflammation; Metabolism; Microbiology/Virology; Others
	Bestatin (Ubenimex) 是 CD13 (Aminopeptidase N)/APN 和 leukotriene A4 hydrolase 抑制剂，可用于癌症研究。
TL0008	Gigantol	Wnt/beta-catenin; Glucosidase	Cytoskeletal Signaling; Metabolism; Stem Cells
	Gigantol 是一种联苄基化合物，从几种药用兰花中获得，是一种Wnt/β-catenin 通路抑制剂，具有抗肿瘤活性。
TN1484	Cheilanthifoline	NF-κB; Antifection	Microbiology/Virology; NF-κB
	Cheilanthifoline has anti-osteoclastogenic property, it gives significant inhibitions on receptor activator of nuclear factor-κB ligand-induced differentiation of mouse bone marrow-derived macrophages into multinucleated osteoclasts.
TN1009	Epimagnolin B	NF-κB; NO Synthase; Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation; NF-κB
	Epimagnolin B 是一种双环氧木质素，分离自木兰中。它能够抑制 LPS 激活的小胶质细胞中 NO 的产生。它具有抗过敏以及抗炎作用。
TN2533	1-Hydroxy-2,3,4,7-tetramethoxyxanthone	5-HT Receptor	GPCR/G Protein; Neuroscience
	1-Hydroxy-2,3,4,7-tetramethoxy-xanthone has vasodilatory action, it can cause vasodilation in the coronary artery pre-contracted with 1uM 5-hydroxytryptamine (5-HT), with the EC 50 value of 6.6±1.4 uM. 1-Hydroxy-2,3,4,7-tetramethoxyxanthone can effectivel
TN2534	1-Hydroxy-2,3,5-trimethoxyxanthone	IκB/IKK; Calcium Channel; NOS; 5-HT Receptor; COX	GPCR/G Protein; Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism; Neuroscience; NF-κB
	1-Hydroxy-2,3,5-trimethoxyxanthone (HM-1) has vasodilator action ,which involves both an endothelium-dependent mechanism involving NO and an endothelium-independent mechanism by inhibiting Ca(2+) influx through L-type voltage-operated Ca(2+) channels; a minor contribution to the effects of HM-1 may be related to inhibition of the protein kinase C-mediated release of intracellular Ca(2+) stores. HM-1,at the concentration of 1 ug/mL, can effectively inhibit the osteoclast differentiation in a co-c...

天然产物

Cat.No: T5751

Target: Others

Cat.No: T3004

Synonym: 鲨肝醇,Batilolum,Stearyl monoglyceride,Batyl alcohol,1-O-Octadecylglycerol

Target: Others, Endogenous Metabolite

3′,4′,7-Trihydroxyflavone

Cat.No: TN3209

Target: ATPase, Others, p38 MAPK, NF-κB

Cat.No: T2820

Synonym: 黄豆黄苷,Glycitein-7-β-O-glucoside,Glycitein 7-O-β-glucoside

Target: Others, Influenza Virus, Antibacterial

Hydroxysafflor yellow A

Cat.No: T3674

Synonym: 藏红花,羟基红花黄色素A,HSYA,Safflomin A

Target: TGF-beta/Smad

3,7,4'-Trihydroxyflavone

Cat.No: TN2143

Synonym: Resokaempferol,5-Deoxykampferol

Target: DNA

Cat.No: T1257

Synonym: Ubenimex,乌苯美司

Target: Others, Aminopeptidase, Antibacterial, Antibiotic, LTR

Cat.No: TL0008

Target: Wnt/beta-catenin, Glucosidase

Cheilanthifoline

Cat.No: TN1484

Target: NF-κB, Antifection

Cat.No: TN1009

Target: NF-κB, NO Synthase, Prostaglandin Receptor

1-Hydroxy-2,3,4,7-tetramethoxyxanthone

Cat.No: TN2533

Target: 5-HT Receptor

1-Hydroxy-2,3,5-trimethoxyxanthone

Cat.No: TN2534

Target: IκB/IKK, Calcium Channel, NOS, 5-HT Receptor, COX

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-03235	BST2 Protein, Human, Recombinant (His) bone marrow stromal cell antigen 2,CD317,TETHERIN	Human	HEK293 Cells
	BST2 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 14.9 kDa and the accession number is Q10589.
TMPY-03038	CD157 Protein, Rat, Recombinant (His) bone marrow stromal cell antigen 1	Rat	HEK293 Cells
	CD157 Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 31.2 kDa and the accession number is Q63072.
TMPY-03037	CD157 Protein, Rat, Recombinant (hFc) bone marrow stromal cell antigen 1	Rat	HEK293 Cells
	CD157 Protein, Rat, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 56.8 kDa and the accession number is Q63072.
TMPH-01011	PRG2 Protein, Human, Recombinant (GST & His) Bone marrow proteoglycan,PRG2,Proteoglycan 2	Human	E. coli
	Cytotoxin and helminthotoxin. Also induces non-cytolytic histamine release from human basophils. Involved in antiparasitic defense mechanisms and immune hypersensitivity reactions. The proform acts as a proteinase inhibitor, reducing the activity of PAPPA. PRG2 Protein, Human, Recombinant (GST & His) is expressed in E. coli expression system with N-6xHis-GST tag. The predicted molecular weight is 41.2 kDa and the accession number is P13727.
TMPY-00968	CD157 Protein, Human, Recombinant (His) bone marrow stromal cell antigen 1,CD157	Human	HEK293 Cells
	CD157 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 31.4 kDa and the accession number is Q10588-1.
TMPY-03193	BST2 Protein, Human, Recombinant (hFc) CD317,TETHERIN,bone marrow stromal cell antigen 2	Human	HEK293 Cells
	BST2 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 41 kDa and the accession number is Q10589.
TMPY-01178	CD157 Protein, Mouse, Recombinant (His) CD157,bone marrow stromal cell antigen 1,BP-3,Bsta1...	Mouse	HEK293 Cells
	CD157 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 30.9 kDa and the accession number is A0A0R4J190.
TMPY-04742	BST2 Protein, Mouse, Recombinant (His) Bst-2,GREG,bone marrow stromal cell antigen 2,C8704...	Mouse	HEK293 Cells
	BST2 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 13.6 kDa and the accession number is Q8R2Q8.
TMPY-02674	BST2 Protein, Mouse, Recombinant (hFc) 2310015I10Rik,bone marrow stromal cell antigen 2,C8...	Mouse	HEK293 Cells
	BST2 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 40 kDa and the accession number is Q8R2Q8.
TMPJ-00476	BMPG Protein, Human, Recombinant (His) Bone Marrow Proteoglycan,PRG2,Proteoglycan 2,Eosino...	Human	HEK293 Cells
	Bone Marrow Proteoglycan (BMPG) is a secreted protein that contains one C-type lectin domain. BMPG is the predominant constituent of the crystalline core of the eosinophil granule. BMPG is highly expressed in placenta and pregnancy serum. BMPG may be involved in antiparasitic defense mechanisms as a cytotoxin and helminthotoxin. BMPG induces non-cytolytic histamine release from human basophils. In addition, BMPG also participated in antiparasitic defense mechanisms and immune hypersensitivity re...
TMPH-01773	ELANE Protein, Human, Recombinant (GST) Neutrophil elastase,ELA2,Medullasin,Elastase-2,ELANE,Bone	Human	E. coli
	Modifies the functions of natural killer cells, monocytes and granulocytes. Inhibits C5a-dependent neutrophil enzyme release and chemotaxis. Capable of killing E.coli but not S.aureus in vitro; digests outer membrane protein A (ompA) in E.coli and K.pneumoniae. ELANE Protein, Human, Recombinant (GST) is expressed in E. coli expression system with N-GST tag. The predicted molecular weight is 52.6 kDa and the accession number is P08246.
TMPJ-00202	CD157 Protein, Human, Recombinant (hFc) Cyclic ADP-ribose hydrolase 2,cADPr hydrolase 2,ADP-ribosyl ...	Human	HEK293 Cells
	The cluster of differentiation (CD) system is a glycosyl phosphatidylinositol anchored membrane protein that belongs to the CD38 family.It is generally used in immunophynotyping. CD157 was discovered in a bone marrow stromal cell line where it facilitates pre-B-cell growth. CD157 is a bifunctional ectoenzyme that exhibits both ADP-ribosyl cyclase and cyclic ADP ribose hydrolase activities followed with CD38. It plays a role in rheumatoid arthritis (RA) due to its enhanced expression in RA-derive...
TMPJ-01470	SCF Protein, Human, Recombinant Mast Cell Growth Factor,c-Kit ligand,KITLG,MGF,Stem Cell Fac...	Human	E. coli
	Stem Cell Factor (SCF) is a hematopoietic growth factor that exerts its activity at the early stages of hematopoiesis. SCF stimulates the proliferation of myeloid, erythroid, and lymphoid progenitors in bone marrow cultures and has been shown to act synergistically with colony stimulating factors.
TMPJ-00235	TPO Protein, Human, Recombinant (His) Megakaryocyte growth and development factor,C-mpl ligand,Thr...	Human	HEK293 Cells
	Thrombopoietin (TPO) is a glycoprotein hormone which belongs to the EPO/TPO family. It produced by the liver and kidney which regulates the production of platelets. TPO stimulates the production and differentiation of megakaryocytes, the bone marrow cells that bud off large numbers of platelets. Lineage-specific cytokine affects the proliferation and maturation of megakaryocytes from their committed progenitor cells. It acts at a late stage of megakaryocyte development. It may be the major physi...
TMPY-04830	GAS6 Protein, Mouse, Recombinant (His) growth arrest-specific 6,Gas-6	Mouse	HEK293 Cells
	The growth arrest-specific 6 gene (GAS6) is a member of the family of plasma vitamin K-dependent proteins, which are able to bind to phospholipids using an N-terminal gamma-carboxyglutamic acid domain. GAS6 is a vitamin K-dependent protein, plays a role in the survival, proliferation, migration, differentiation, adhesion, and apoptosis of cells. The growth arrest-specific 6 (GAS6) has been implicated in systemic inflammation and coagulation. Growth arrest-specific 6 (GAS6), plays a role in tumor...
TMPJ-00038	IL-7 Protein, Mouse, Recombinant (His) interleukin-7,白介素,IL-7,IL-7 interleukin-7,PBGF,Lymphopoietin...	Mouse	HEK293 Cells
	Mouse interleukin-7(IL-7) is the member of hemopoietin family which is important to the differentiation, proliferation, and survival of lymphocyte. Mouse IL-7 shares approximately 88% aa sequence identity with rat IL-7 and 58-60% with human, equine, bovine, ovine, porcine, feline and canine IL-7. It is widely expressed in primary and secondary lymphoid tissues cell and stromal epithelial cells of the thymus, bone marrow, and intestines. IL-7 activation of IL-7 R alpha is critical for both T cell...
TMPY-05004	FGF-4 Protein, Human, Recombinant HST-1,KFGF,fibroblast growth factor 4,HSTF1,K-FGF,HST,HBGF-4	Human	E. coli
	FGF (fibroblast growth factor) signalling is known to be required for many aspects of mesoderm formation and patterning during Xenopus development and has been implicated in regulating genes required for the specification of both blood and skeletal muscle lineages. Fibroblast growth factor 4 (FGF4) signaling induces differentiation from embryonic stem cells (ESCs) via the phosphorylation of downstream molecules such as mitogen-activated protein kinase/extracellular signal-related kinase (MEK) a...
TMPY-01280	FOLR2 Protein, Human, Recombinant (His) FBP,β-HFR,FR-P3,BETA-HFR,folate receptor 2 (fetal),FR-BETA,F...	Human	HEK293 Cells
	Folate receptor beta, also known as Folate receptor 2, FBP, and FOLR2, is a member of the folate receptor family. FOLR2 is expressed in placenta and hematopoietic cells. The expression of FOLR2 is increased in malignant tissues. Members of the Folate receptor family members (FOLRs) have a high affinity for folic acid and for several reduced folic acid derivatives. They mediate the delivery of 5-methyltetrahydrofolate to the interior of, out of within, or between cells in a process known as potoc...
TMPK-01193	GPRC5D Protein-VLP, Mouse, Recombinant MGC129713,orphan G-protein coupled receptor,GPRC5D,MGC129714	Mouse	HEK293 Cells
	Chimeric antigen receptor (CAR) T cells, a type of cell-based immunotherapy, have shown some promising results in multiple myeloma, a bone marrow cancer.The orphan G protein–coupled receptor, class C group 5 member D (GPRC5D), normally expressed only in the hair follicle, Using quantitative immunofluorescence, we determined that GPRC5D protein is expressed on CD138 MM cells from primary marrow samples with a distribution that was similar to, but independent of, BCMA. GPRC5D Protein-VLP, Mouse, R...
TMPK-00528	GPRC5D Protein-VLP, Cynomolgus, Recombinant MGC129713,GPRC5D,MGC129714,orphan G-protein coupled receptor	Cynomolgus	HEK293 Cells
	Chimeric antigen receptor (CAR) T cells, a type of cell-based immunotherapy, have shown some promising results in multiple myeloma, a bone marrow cancer.The orphan G protein–coupled receptor, class C group 5 member D (GPRC5D), normally expressed only in the hair follicle, Using quantitative immunofluorescence, we determined that GPRC5D protein is expressed on CD138 MM cells from primary marrow samples with a distribution that was similar to, but independent of, BCMA. GPRC5D Protein-VLP, Cynomolg...
TMPJ-01319	TINAGL1 Protein, Human, Recombinant (His) LCN7,Tubulointerstitial nephritis antigen-like (TINAGL1),Oxi...	Human	HEK293 Cells
	TINAGL1 is a secreted protein and contains one SMB (somatomedin-B) domain. TINAGL1 is expressed in aorta, lymph nodes, heart, bone marrow, placenta, lung, kidney, skeletal muscle, pancreas, thyroid, adrenal gland and so on. TINAGL1 may be implicated in the adrenocortical zonation and in mechanisms for repressing the CYP11B1 gene expression in adrenocortical cells.
TMPK-00685	CYTL1 Protein, Mouse, Recombinant (hFc) CYTL1,C4orf4,Protein C17	Mouse	HEK293 Cells
	Cytokine-like protein 1 (Cytl1), also named Protein C17 or C4orf4 is located on human chromosome 4p15-p16 and encodes a polypeptide of 126 amino acid residues that displays characteristics of a secretory protein. Cytl1 is expressed by a sub-population of CD34 human mononuclear cells from bone marrow and cord blood, and by chondrocytes (cartilage-forming cells).
TMPJ-00665	ADAMDEC1 Protein, Human, Recombinant (His) a disintegrin and metalloproteinase domain-like protein decy...	Human	HEK293 Cells
	ADAM DEC1 protein is expressed highly in the small intestine and appendix, moderately in lymph node, mucosal lining of the colon, thymus, spleen and very weakly in the bone marrow. ADAM DEC1 is induced during DC maturation and up-regulated in response to T-cell signals. It may play an important role in the control of the immune response and during pregnancy.
TMPK-00234	CD84 Protein, Human, Recombinant (His & Avi) CD84,DKFZp781E2378,Hly9-beta,Hly9-β,CD84 molecule,SLAMF5,LY9...	Human	HEK293 Cells
	Chronic lymphocytic leukemia (CLL) is characterized by the accumulation of CD5 B lymphocytes in peripheral blood, lymphoid organs and bone marrow. The main feature of the disease is accumulation of the malignant cells due to decreased apoptosis. CD84 belongs to the signaling lymphocyte activating molecule family of immunoreceptors, and has an unknown function in CLL cells.
TMPJ-00567	NCR1 Protein, Human, Recombinant (hFc) hNKp46,Natural cytotoxicity triggering receptor 1,NCR1,Natur...	Human	HEK293 Cells
	Natural cytotoxicity triggering receptor 1(NCR1) is a single-pass type I membrane protein .It contains 2 Ig-like (immunoglobulin-like) domains and belongs to the natural cytotoxicity receptor (NCR) family. The protein is a natural killer (NK) lymphocyte-activating receptor. It is involved in major aspects of NK immune function and shows a high degree of lineage specificity in blood and bone marrow.
TMPK-01298	BST2 Protein, Cynomolgus, Recombinant (His) HM1.24 antigen,PDCA-1,BST2,TETHERIN,BST-2,NPC-A-7,CD317	Cynomolgus	HEK293 Cells
	Interferon-induced BST2 (bone marrow stromal cell antigen 2) inhibits viral replication by tethering enveloped virions to the cell surface to restrict viral release and by inducing the NFKB-dependent antiviral immune response. BST2 expression was significantly increased during porcine epidemic diarrhea virus (PEDV) infection of Vero cells by IRF1 targeting its promoter. Both the BST2 and N protein interacted with the E3 ubiquitin ligase MARCHF8/MARCH8 and the cargo receptor.
TMPJ-00925	Grancalcin Protein, Human, Recombinant Grancalcin,GCA,GCL	Human	E. coli
	Grancalcin (GCA) is a cytoplasmic granule membrane protein that contains 4 EF-hand domains. GCA is calcium-binding protein and particularly abundant in human neutrophils. GCA is highly expressed in bone marrow, and it can be detected in neutrophils and macrophages. Calcium-binding protein GCA cooperates with SRI and LCP1, so it may play a role in the adhesion of neutrophils to fibronectin. GCA also may play a role in the formation of focal adhesions.
TMPK-00212	CD300A Protein, Mouse, Recombinant (His) MAIR-I,IGSF12,IRp60,Mcipr1,CLM8,NKRL,IRC1,CD300a,Pigr4,CLM-8...	Mouse	HEK293 Cells
	CD300a is an inhibitory receptor for mast cells and eosinophils in allergic inflammation (AI); however, the spatiotemporal expression of CD300a and its potential roles in the resolution of AI are still to be determined.CD300a expression on peritoneal cells is regulated from inflammation to resolution. CD300a activation on mouse bone marrow-derived mast cells regulated ALX/FPR2 expression levels following IgE-mediated activation. CD300A Protein, Mouse, Recombinant (His) is expressed in HEK293 mam...
TMPK-00561	CD300A Protein, Cynomolgus, Recombinant (His) Mcipr1,IGSF12,IRp60,LMIR1,CD300a,MAIR-I,Pigr4,CLM-8,IRC1,NKR...	Cynomolgus	HEK293 Cells
	CD300a is an inhibitory receptor for mast cells and eosinophils in allergic inflammation (AI); however, the spatiotemporal expression of CD300a and its potential roles in the resolution of AI are still to be determined.CD300a expression on peritoneal cells is regulated from inflammation to resolution. CD300a activation on mouse bone marrow-derived mast cells regulated ALX/FPR2 expression levels following IgE-mediated activation. CD300A Protein, Cynomolgus, Recombinant (His) is expressed in HEK29...
TMPK-00560	CD300A Protein, Cynomolgus, Recombinant (Avi), Biotinylated IGSF12,Mcipr1,NKRL,IRp60,LMIR1,Pigr4,MAIR-I,CLM-8,CD300a,CLM...	Cynomolgus	HEK293 Cells
	CD300a is an inhibitory receptor for mast cells and eosinophils in allergic inflammation (AI); however, the spatiotemporal expression of CD300a and its potential roles in the resolution of AI are still to be determined.CD300a expression on peritoneal cells is regulated from inflammation to resolution. CD300a activation on mouse bone marrow-derived mast cells regulated ALX/FPR2 expression levels following IgE-mediated activation. CD300A Protein, Cynomolgus, Recombinant (Avi), Biotinylated is expr...
TMPK-00186	CD300A Protein, Human, Recombinant (Avi) Mcipr1,CLM-8,MAIR-I,IGSF12,NKRL,LMIR1,CLM8,IRC1,IRp60,CD300a...	Human	HEK293 Cells
	CD300a is an inhibitory receptor for mast cells and eosinophils in allergic inflammation (AI); however, the spatiotemporal expression of CD300a and its potential roles in the resolution of AI are still to be determined.CD300a expression on peritoneal cells is regulated from inflammation to resolution. CD300a activation on mouse bone marrow-derived mast cells regulated ALX/FPR2 expression levels following IgE-mediated activation. CD300A Protein, Human, Recombinant (Avi) is expressed in HEK293 mam...
TMPK-00559	CD300A Protein, Cynomolgus, Recombinant (Avi) LMIR1,NKRL,CLM8,Mcipr1,Pigr4,IGSF12,MAIR-I,IRp60,IRC1,CLM-8,...	Cynomolgus	HEK293 Cells
	CD300a is an inhibitory receptor for mast cells and eosinophils in allergic inflammation (AI); however, the spatiotemporal expression of CD300a and its potential roles in the resolution of AI are still to be determined.CD300a expression on peritoneal cells is regulated from inflammation to resolution. CD300a activation on mouse bone marrow-derived mast cells regulated ALX/FPR2 expression levels following IgE-mediated activation. CD300A Protein, Cynomolgus, Recombinant (Avi) is expressed in HEK29...
TMPY-03873	CLEC4B2 Protein, Rat, Recombinant (His) Aplra1,CLEC4B2,C-type lectin domain family 4, member b2	Rat	HEK293 Cells
	Clec4b2, also known as mDCAR1, is a member of the DCIR/DCAR family. Expression of Clec4b2 was strongly tissue dependent. Clec4b2 expression on DCs was restricted to the CD8(+) DC subset in spleen and thymus and on subpopulations of CD11b(+) myeloid cells in bone marrow and spleen, whereas the molecule was not detectable on both cell types in lymph nodes and peripheral blood. Clec4b2 is a functional receptor on cells of the immune system and provides further insights into the regulation of immune...
TMPJ-00582	PRG3 Protein, Human, Recombinant (His) Prepro-MBPH,Prepro-Major Basic Protein Homolog,Eosinophil Ma...	Human	HEK293 Cells
	Proteoglycan 3, also known as Eosinophil major basic protein homolog, Prepro-major basic protein homolog, PRG3 and MBPH, contains one C-type lectin domain. Proteoglycans are a major component of the animal extracellular matrix. PRG3 localizes to the eosinophil secondary granule and is expressed in bone marrow, not detected in placenta. PRG3 has similar cytotoxic and cytostimulatory activities to PRG2/MBP. In vitro, PRG3 can stimulate neutrophil superoxide production and IL8 release, histamine an...
TMPJ-01222	LRRC25 Protein, Human, Recombinant (His) Leucine-rich repeat-containing protein 25,MAPA,Monocyte and ...	Human	HEK293 Cells
	Leucine-rich repeat-containing protein 25(LRRC25) is a single-pass type I membrane protein and contains 3 LRR (leucine-rich) repeats. The protein expressed in plasmacytoid dendritic cells (PDC), monocyte-derived dendritic cells (MDDC), granulocytes, monocytes, B-lymphocytes, peripheral blood leukocytes, spleen, bone marrow, and, to a lesser extent, lymph nodes, fetal liver, and appendix but not in thymus. The protein may be involved in the activation of cells of innate and acquired immunity.
TMPY-04380	DYRK3 Protein, Human, Recombinant (His & GST) REDK,RED,DYRK5,dual-specificity tyrosine-(Y)-phosphorylation...	Human	Baculovirus Insect Cells
	Dual specificity tyrosine-phosphorylation-regulated kinase 3, also known as Regulatory erythroid kinase, REDK and DYRK3, is a nucleus protein which belongs to theprotein kinase superfamily, CMGC Ser/Thr protein kinase family and MNB/DYRK subfamily. DYRKs are an emerging family of dual-specificity kinases that play key roles in cell proliferation, survival, and development. DYRK3 contains oneprotein kinase domain. Isoform 1 and isoform 2 of DYRK3 are highly expressed in testis and in hemat...
TMPK-00187	CD300A Protein, Human, Recombinant (Avi), Biotinylated Pigr4,LMIR1,IGSF12,CLM-8,CD300a,CLM8,IRC1,MAIR-I,Mcipr1,IRp6...	Human	HEK293 Cells
	CD300a is an inhibitory receptor for mast cells and eosinophils in allergic inflammation (AI); however, the spatiotemporal expression of CD300a and its potential roles in the resolution of AI are still to be determined.CD300a expression on peritoneal cells is regulated from inflammation to resolution. CD300a activation on mouse bone marrow-derived mast cells regulated ALX/FPR2 expression levels following IgE-mediated activation. CD300A Protein, Human, Recombinant (Avi), Biotinylated is expressed...
TMPH-02135	SPRED1 Protein, Human, Recombinant (His & Myc & SUMO) SPRED1,Sprouty-related, EVH1 domain-containing protein 1	Human	E. coli
	Tyrosine kinase substrate that inhibits growth-factor-mediated activation of MAP kinase. Negatively regulates hematopoiesis of bone marrow. Inhibits fibroblast growth factor (FGF)-induced retinal lens fiber differentiation, probably by inhibiting FGF-mediated phosphorylation of ERK1/2. Attenuates actin stress fiber formation via inhibition of TESK1-mediated phosphorylation of cofilin. Inhibits TGFB-induced epithelial-to-mesenchymal transition in lens epithelial cells. SPRED1 Protein, Human, Reco...
TMPH-02740	IL-31R alpha Protein, Mouse, Recombinant (His) ZcytoR17,Interleukin-31 receptor subunit alpha,Novel cytokin...	Mouse	E. coli
	Associates with OSMR to form the interleukin-31 receptor which activates STAT3 and to a lower extent STAT1 and STAT5. May function in skin immunity. Mediates IL31-induced itch, probably in a manner dependent on cation channels TRPA1 and TRPV1. Positively regulates numbers and cycling status of immature subsets of myeloid progenitor cells in bone marrow in vivo and enhances myeloid progenitor cell survival in vitro. IL-31R alpha Protein, Mouse, Recombinant (His) is expressed in E. coli expression...
TMPJ-01268	ERP27 Protein, Human, Recombinant (His) C12orf46,ER Protein 27,Endoplasmic Reticulum Resident Protei...	Human	HEK293 Cells
	Endoplasmic reticulum resident protein 27, also known as ER protein 27, C12orf46 and ERP27, is an endoplasmic reticulum luminal protein which is a member of the protein disulfide isomerase family. ERP27 contains one thioredoxin domain and does not contain a CXXC active site motif. ERP27 is widely expressed in many tissues; it has highest expression in pancreas, with lower levels in spleen, lung, kidney, thymus, and bone marrow. ERP27 interacts with PDIA3 and binds somatostatin-14 via hydrophobic...
TMPJ-00806	HMBS Protein, Human, Recombinant (His) Pre-Uroporphyrinogen Synthase,PBG-D,Hydroxymethylbilane Synt...	Human	HEK293 Cells
	Porphobilinogen Deaminase (HMBS) is a member of the HMBS family. PBGD is the third enzyme of the heme biosynthetic pathway and catalyzes the head to tail condensation of four porphobilinogen molecules into the linear hydroxymethylbilane. HMBS is involved in the production of heme, which is important for all of the body's organs, although it is most abundant in the blood, bone marrow, and liver. In addition, Heme is an essential component of iron-containing proteins called hemoproteins, including...
TMPJ-01253	Serpin A3N Protein, Mouse, Recombinant (His) Serpina3n,Serine protease inhibitor A3N,Spi2,Serpin A3N	Mouse	HEK293 Cells
	Serine protease inhibitor A3N(Serpin A3N) is a serine protease inhibitor that is structurally related to α1 antichymotrypsin encoded by the SERPINA3 gene. Serpin A3N is highly expressed in brain, testis, lung, thymus, and spleen. It is expressed with low levels in bone marrow, kidney and skeletal muscle. Serpin A3N secreted by Sertoli cells may regulate the activity of locally produced Granzyme B. Granzyme B inhibition by Serpin A3N may therefore regulate Granzyme Bmediated killing by cytotoxic ...
TMPJ-00272	RELT/TNFRSF19L Protein, Human, Recombinant (hFc) RELT,TNFRSF19L,Receptor expressed in lymphoid tissues,Tumor ...	Human	HEK293 Cells
	Tumor necrosis factor receptor superfamily member 19L (TNFRSF19L), also known as Receptor expressed in lymphoid tissues and RELT, is a member of the TNF-receptor superfamily. TNFRSF19L is a single-pass type membrane protein and contains one TNFR-Cys repeat. TNFRSF19L is highly expressed in spleen, lymph node, thymus, peripheral blood leukocytes, bone marrow and fetal liver. It has been shown TNFRSF19L activates the NF-kappaB pathway and selectively binds TNF receptor-associated factor 1 (TRAF1)....
TMPJ-00128	SLAMF2 Protein, Mouse, Recombinant (His) BCM1,SLAMF2,CD48,BLAST1,SLAM Family Member 2	Mouse	HEK293 Cells
	CD48 is a GPI-linked protein in the CD2 family of immunoglobulin superfamily proteins. CD48 is expressed on most lineage-committed hematopoietic cells but not on hematopoietic stem cells or multipotent hematopoietic progenitors. Among dendritic cells (DC), CD48 is selectively expressed on circulating myeloid DC and resident bone marrow and thymus DC. CD2, 2B4, and heparan sulfate function as CD48 ligands. CD48 is competent to transduce signals and can also trigger signaling through CD2 or 2B4. C...
TMPJ-00120	NKp80/KLRF1 Protein, Human, Recombinant (His) Lectin-like receptor F1,C-type lectin domain family 5 member...	Human	HEK293 Cells
	Killer cell lectin-like receptor subfamily F member 1 (KLRF1) is known as NKp80. Human NKp80, a member of the C-type lectin family of proteins (1 - 3), is 231 aa in length with a 38 amino acid (aa) cytoplasmic region, a 21 aa transmembrane region, and a 172 aa extracellular domain (ECD). The protein strongly expressed in peripheral blood leukocytes and spleen, with weaker expression in lymph node and adult liver, and no expression detected in bone marrow, thymus, and fetal liver. Its' function i...
TMPJ-01365	SLAMF8 Protein, Human, Recombinant (His) CD353,SLAM family member 8,BCM-like membrane protein,B-lymph...	Human	HEK293 Cells
	SLAM family member 8 (SLAMF8) is a single-pass type I membrane protein and contains 1 Ig-like C2-type domain. SLAMF8 is a member of the CD2 family of cell surface proteins involved in lymphocyte activation. These proteins are characterized by Ig domains and studies of a similar protein in mouse suggest that it may function during B cell lineage commitment. SLAMF8 is expressed in lymph node, spleen, thymus and bone marrow. It may play a role in B-lineage commitment and/or modulation of signaling...
TMPJ-00926	GCA Protein, Human, Recombinant (GST) GCA,Grancalcin,GCL	Human	E. coli
	Grancalcin (GCA) is a member of the penta EF hand subfamily which includes sorcin, calpain and ALG2. Grancalcin is highly expressed bone marrow and also can detected in neutrophils and macrophages. Grancalcin interacts with L-plastin which known to have actin bundling activity. It indicates that Grancalcin may play an important role in the adhesion of neutrophils to fibronectin. Furthermore, Grancalcin localization is dependent upon calcium and magnesium. It associates with both the granule and ...
TMPY-04073	MRPL44 Protein, Human, Recombinant (His) mitochondrial ribosomal protein L44,COXPD16,L44MT,MRP-L44	Human	Baculovirus Insect Cells
	MRPL44 (Mitochondrial Ribosomal Protein L44) is a Protein Coding gene. MRPL44 encodes a protein in the large subunit of the mitochondrial ribosome and is suggested to locate near the tunnel exit of the yeast mitochondrial ribosome. It belongs to the mitochondrion-specific ribosomal protein mL44 subfamily. In the patient fibroblasts, decreased MRPL44 affected assembly of the large ribosomal subunit and stability of 16S rRNA leading to complex IV deficiency. It may have a function in the assembly/...
TMPJ-01282	Serpin B12 Protein, Human, Recombinant (His) SERPINB12,Serine Protease Inhibitor-clade B12,Serpin B12	Human	HEK293 Cells
	Serpin B12 is a member of the serpin family. Serpins are the largest and most diverse family of serine protease inhibitors. Most serpins are secreted and attain physiologic concentrations in the blood and extracellular fluids. Serpin B12 is expressed in many tissues, including brain, bone marrow, lymph node, heart, lung, liver, pancreas, testis, ovary, and intestine. Serpins are involved in a number of fundamental biological processes such as blood coagulation, complement activation, fibrinolysi...
TMPY-01718	Serpin B12 Protein, Mouse, Recombinant (His) 2300003F07Rik,4833409F13Rik,serpin peptidase inhibitor, clad...	Mouse	Baculovirus Insect Cells
	Serpins are the largest and most diverse family of serine protease inhibitors which are involved in some fundamental biological processes such as blood coagulation, complement activation, fibrinolysis, angiogenesis, inflammation and tumor suppression and are expressed in a cell-specific manner. Most serpins are secreted and attain physiologic concentrations in the blood and extracellular fluids. Mouse SerpinB12 is a cytoplasm protein that belongs to the serpin family and Ov-serpin subfamily. It ...
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重组蛋白

BST2 Protein, Human, Recombinant (His)

Cat.No: TMPY-03235

Species: Human

Expression System: HEK293 Cells

CD157 Protein, Rat, Recombinant (His)

Cat.No: TMPY-03038

Species: Rat

Expression System: HEK293 Cells

CD157 Protein, Rat, Recombinant (hFc)

Cat.No: TMPY-03037

Species: Rat

Expression System: HEK293 Cells

PRG2 Protein, Human, Recombinant (GST & His)

Cat.No: TMPH-01011

Species: Human

Expression System: E. coli

CD157 Protein, Human, Recombinant (His)

Cat.No: TMPY-00968

Species: Human

Expression System: HEK293 Cells

BST2 Protein, Human, Recombinant (hFc)

Cat.No: TMPY-03193

Species: Human

Expression System: HEK293 Cells

CD157 Protein, Mouse, Recombinant (His)

Cat.No: TMPY-01178

Species: Mouse

Expression System: HEK293 Cells

BST2 Protein, Mouse, Recombinant (His)

Cat.No: TMPY-04742

Species: Mouse

Expression System: HEK293 Cells

BST2 Protein, Mouse, Recombinant (hFc)

Cat.No: TMPY-02674

Species: Mouse

Expression System: HEK293 Cells

BMPG Protein, Human, Recombinant (His)

Cat.No: TMPJ-00476

Species: Human

Expression System: HEK293 Cells

ELANE Protein, Human, Recombinant (GST)

Cat.No: TMPH-01773

Species: Human

Expression System: E. coli

CD157 Protein, Human, Recombinant (hFc)

Cat.No: TMPJ-00202

Species: Human

Expression System: HEK293 Cells

SCF Protein, Human, Recombinant

Cat.No: TMPJ-01470

Species: Human

Expression System: E. coli

TPO Protein, Human, Recombinant (His)

Cat.No: TMPJ-00235

Species: Human

Expression System: HEK293 Cells

GAS6 Protein, Mouse, Recombinant (His)

Cat.No: TMPY-04830

Species: Mouse

Expression System: HEK293 Cells

IL-7 Protein, Mouse, Recombinant (His)

Cat.No: TMPJ-00038

Species: Mouse

Expression System: HEK293 Cells

FGF-4 Protein, Human, Recombinant

Cat.No: TMPY-05004

Species: Human

Expression System: E. coli

FOLR2 Protein, Human, Recombinant (His)

Cat.No: TMPY-01280

Species: Human

Expression System: HEK293 Cells

GPRC5D Protein-VLP, Mouse, Recombinant

Cat.No: TMPK-01193

Species: Mouse

Expression System: HEK293 Cells

GPRC5D Protein-VLP, Cynomolgus, Recombinant

Cat.No: TMPK-00528

Species: Cynomolgus

Expression System: HEK293 Cells

TINAGL1 Protein, Human, Recombinant (His)

Cat.No: TMPJ-01319

Species: Human

Expression System: HEK293 Cells

CYTL1 Protein, Mouse, Recombinant (hFc)

Cat.No: TMPK-00685

Species: Mouse

Expression System: HEK293 Cells

ADAMDEC1 Protein, Human, Recombinant (His)

Cat.No: TMPJ-00665

Species: Human

Expression System: HEK293 Cells

CD84 Protein, Human, Recombinant (His & Avi)

Cat.No: TMPK-00234

Species: Human

Expression System: HEK293 Cells

NCR1 Protein, Human, Recombinant (hFc)

Cat.No: TMPJ-00567

Species: Human

Expression System: HEK293 Cells

BST2 Protein, Cynomolgus, Recombinant (His)

Cat.No: TMPK-01298

Species: Cynomolgus

Expression System: HEK293 Cells

Grancalcin Protein, Human, Recombinant

Cat.No: TMPJ-00925

Species: Human

Expression System: E. coli

CD300A Protein, Mouse, Recombinant (His)

Cat.No: TMPK-00212

Species: Mouse

Expression System: HEK293 Cells

CD300A Protein, Cynomolgus, Recombinant (His)

Cat.No: TMPK-00561

Species: Cynomolgus

Expression System: HEK293 Cells

CD300A Protein, Cynomolgus, Recombinant (Avi), Biotinylated

Cat.No: TMPK-00560

Species: Cynomolgus

Expression System: HEK293 Cells

CD300A Protein, Human, Recombinant (Avi)

Cat.No: TMPK-00186

Species: Human

Expression System: HEK293 Cells

CD300A Protein, Cynomolgus, Recombinant (Avi)

Cat.No: TMPK-00559

Species: Cynomolgus

Expression System: HEK293 Cells

CLEC4B2 Protein, Rat, Recombinant (His)

Cat.No: TMPY-03873

Species: Rat

Expression System: HEK293 Cells

PRG3 Protein, Human, Recombinant (His)

Cat.No: TMPJ-00582

Species: Human

Expression System: HEK293 Cells

LRRC25 Protein, Human, Recombinant (His)

Cat.No: TMPJ-01222

Species: Human

Expression System: HEK293 Cells

DYRK3 Protein, Human, Recombinant (His & GST)

Cat.No: TMPY-04380

Species: Human

Expression System: Baculovirus Insect Cells

CD300A Protein, Human, Recombinant (Avi), Biotinylated

Cat.No: TMPK-00187

Species: Human

Expression System: HEK293 Cells

SPRED1 Protein, Human, Recombinant (His & Myc & SUMO)

Cat.No: TMPH-02135

Species: Human

Expression System: E. coli

IL-31R alpha Protein, Mouse, Recombinant (His)

Cat.No: TMPH-02740

Species: Mouse

Expression System: E. coli

ERP27 Protein, Human, Recombinant (His)

Cat.No: TMPJ-01268

Species: Human

Expression System: HEK293 Cells

HMBS Protein, Human, Recombinant (His)

Cat.No: TMPJ-00806

Species: Human

Expression System: HEK293 Cells

Serpin A3N Protein, Mouse, Recombinant (His)

Cat.No: TMPJ-01253

Species: Mouse

Expression System: HEK293 Cells

RELT/TNFRSF19L Protein, Human, Recombinant (hFc)

Cat.No: TMPJ-00272

Species: Human

Expression System: HEK293 Cells

SLAMF2 Protein, Mouse, Recombinant (His)

Cat.No: TMPJ-00128

Species: Mouse

Expression System: HEK293 Cells

NKp80/KLRF1 Protein, Human, Recombinant (His)

Cat.No: TMPJ-00120

Species: Human

Expression System: HEK293 Cells

SLAMF8 Protein, Human, Recombinant (His)

Cat.No: TMPJ-01365

Species: Human

Expression System: HEK293 Cells

GCA Protein, Human, Recombinant (GST)

Cat.No: TMPJ-00926

Species: Human

Expression System: E. coli

MRPL44 Protein, Human, Recombinant (His)

Cat.No: TMPY-04073

Species: Human

Expression System: Baculovirus Insect Cells

Serpin B12 Protein, Human, Recombinant (His)

Cat.No: TMPJ-01282

Species: Human

Expression System: HEK293 Cells

Serpin B12 Protein, Mouse, Recombinant (His)

Cat.No: TMPY-01718

Species: Mouse

Expression System: Baculovirus Insect Cells

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