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Search Results for " learning "

Targets Recommended: GABA Receptor

29

抑制剂 & 化合物

5

天然产物

2

化合物库

14

重组蛋白

1

同位素标记化合物

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Cat. No.	Product Name
L7300	钾通道分子库		152 compounds
	152 种钾通道相关化合物的独特集合，可用于高通量筛选和高内涵筛选；
L2800	5-羟色胺分子库		268 compounds
	268 种生物活性小分子化合物，用于高通量、高内涵筛选；

化合物库

钾通道分子库

Cat.No: L7300

Compounds: 152

5-羟色胺分子库

Cat.No: L2800

Compounds: 268

Cat. No.	Product Name	Target	Signaling Pathways
T21793	CGP 35348	GABA Receptor	Membrane transporter/Ion channel; Neuroscience
	CGP 35348 是 GABAB 受体的选择性拮抗剂 (EC50 = 34 μM)。 CGP 35348 可用于研究白化新生小鼠脑损伤后的神经肌肉协调和空间学习。
T2301	SB 202190 FHPI,SB202190	Apoptosis; p38 MAPK; Autophagy	Apoptosis; Autophagy; MAPK
	SB 202190 (FHPI) 是一种 p38 MAPK 抑制剂，可以抑制 p38α 和 p38β2 (IC50=50/100 nM)，具有选择性和细胞渗透性。SB 202190 具有抗肿瘤活性，还可以诱导人胚胎干细胞向心肌细胞分化。
T21715	BRD6688	HDAC	Chromatin/Epigenetic; DNA Damage/DNA Repair
	BRD6688 为 HDAC2 的选择性抑制剂。本品可使原代小鼠神经元细胞中的 H4K12 和 H3K9 组蛋白的乙酰化作用增强。在 CK-p25 小鼠模型中，它可透过血脑屏障，并改善由p25 引起的神经退行性病变相关的记忆缺陷。
T30579	BRD4097	HDAC	Chromatin/Epigenetic; DNA Damage/DNA Repair
	BRD4097是HDAC1/2/3/8检测中的阴性对照品,是一种选择性组蛋白去乙酰化酶（HDAC3）抑制剂，可用于保护b 细胞和改善胰岛素抵抗，有助于促进认知功能和增强学习和记忆的形成。
T8448	ZSET1446 ZSET-1446,ST-101	Calcium Channel; AChR	Membrane transporter/Ion channel; Metabolism; Neuroscience
	ZSET1446 (ST-101) 是一种 T 型钙通道激活剂，用于治疗各类阿尔茨海默病 (AD) 模型中的学习缺陷。
T13452	(S)-MCPG (+)-MCPG	GluR	Neuroscience
	(S)-MCPG ((+)-MCPG) 是一种 I/II 类代谢型谷氨酸受体 (mGluRs) 拮抗剂，可阻断大鼠的空间学习和体内齿状回的长期增强，可用于研究神经系统疾病。
T25450L	GGTI 2147 FA GGTI2147 FA,GGTI-2147 FA,GGTI 2147 FA(191102-87-1 Free base)	Others	Others
	GGTI 2147 FA 是一种选择性 GGT 抑制剂，在海马体实验中双库林诱导的树突棘密度增加被消除，可能会降低小鼠的学习和记忆能力。
T4364	Aftin-4 Aftin 4,Aftin4	Beta Amyloid; Gamma-secretase	Neuroscience; Proteases/Proteasome; Stem Cells
	Aftin-4 是一种 β-淀粉样蛋白42(Aβ42) 的诱导剂。
T23821	BRD4884 BRD-4884,BRD 4884	Others	Others
	BRD4884 is a selective inhibitor of HDAC2 that acts by enhancing the learning and memory processes.
T37375	Uridine-3'-monophosphate (sodium salt)	Others	Others
	Uridine-3'-monophosphate is a nucleoside used in the biochemical synthesis of ribothymidine-3'-phosphate. It has been used as a bioavailable source of uridine in research studies designed to enhance learning and memory.
T22734	DL-AP7	Others	Others
	DL-AP7 是一种竞争性NMDA 拮抗剂和抗惊厥剂。DL-AP7 阻断 NMDA 诱导的惊厥,并导致小鼠在被动回避任务中的学习表现受损。
T61669	BChE-IN-4	Others	Others
	BChE-IN-4 is a highly potent inhibitor of the enzyme butyrylcholinesterase, capable of crossing the blood-brain barrier. It effectively reduces learning and memory impairments resulting from a deficiency in cholinergic activity in a mouse model. BChE-IN-4 holds promise for further investigation in the field of Alzheimer's disease research [1].
T38192	Unifiram	Others	Others
	Unifiram 是一种认知增强剂。 Unifiram 诱导大鼠海马 CA1 区场兴奋性突触后电位 (fEPSP) 幅度的持久增加 (EC50= 27 nM) 并增加大鼠大脑皮层中乙酰胆碱 (ACh) 的释放。
T63708	Calpain-2-IN-1	Others	Others
	Calpain-2-IN-1是选择性的钙蛋白酶-2抑制剂，能够延长 ERK 激活，进而增强学习和记忆。
T70075	KDS2010 mesylate	Others	Others
	KDS2010 is a potent, highly selective, and reversible MAO-B inhibitor which shows 12,500-fold selectivity over MAO-A. KDS2010 overcomes the disadvantages of the irreversible MAO-B inhibitor and significantly attenuates increased astrocytic GABA levels and astrogliosis, thereby enhancing synaptic transmission, and rescuing learning and memory impairments in APP/PS1 mice.
T36809	UoS 12258	Others	Others
	Positive allosteric modulator of AMPA receptors (pEC50 = 5.2 for potentiation of AMPA-mediated currents in vitro). Also potentiates AMPA-mediated synaptic responses in vivo. Improves performance of rats in various learning and memory paradigms Ward et al (2010) Discovery of N-[(2S)-5-(6-fluoro-3-pyridinyl)-2,3-dihydro-1H-inden-2-yl]-2-propanesulfonamide, a novel clinical AMPA receptor positive modulator. J.Med.Chem. 53 5801 PMID:20614889 \|Ward et al (2017) Pharmacological characterization of N-[...
T71622	Duartin	Others	Others
	Duartin is an anti-rickettsial compound. These small molecules and the workflow, featuring a high-throughput phenotypic screen for growth inhibitors of intracellular Rickettsia spp. and machine learning models for the prediction of growth inhibition of an obligate intracellular Gram-negative bacterium, should prove useful in the search for new therapeutic strategies to treat infections from Rickettsia spp. and other obligate intracellular bacteria.
T79333	LZWL02003	Reactive Oxygen Species	Immunology/Inflammation; Metabolism; NF-κB
	LZWL02003为抗神经炎症化合物，对MPP+引起的神经元损害展示保护效果，有效降低ROS水平。此外，LZWL02003能改善鱼藤酮诱导的帕金森病(PD)大鼠模型在认知、记忆、学习及运动能力方面的缺陷。该化合物在神经退行性疾病的研究中具有应用潜力。
T61130	SSTR4 agonist 3	Others	Others
	SSTR4 agonist 3 is a potent compound that activates the SSTR4 receptor. The SSTR4 receptor is highly expressed in the hippocampus and neocortex, which are regions associated with memory, learning, and Alzheimer's disease pathology. SSTR4 agonists demonstrate strong efficacy in rodent models of pain, both acute and chronic, by reducing peripheral nociception and inflammation. Considering its potential application in pain research, SSTR4 agonist 3 is of interest[1].
T76757	Ponezumab
	Ponezumab (PF-04360365) 是一种人源化抗淀粉样蛋白 IgG2单克隆抗体。Ponezumab 可降低中枢神经系统的 Aβ水平，并改善小鼠在各种学习和记忆模型中的表现。Ponezumab 可用于阿尔茨海默症的研究。
T83389	2-Deoxy-D-galactose	Others	Others
	2-Deoxy-D-galactose，作为葡萄糖的类似物，能通过抑制糖酵解过程来抑止肿瘤生长。此外，该化合物还能干扰糖大分子的聚焦化，进而在多种学习任务中损害记忆的巩固。2-Deoxy-D-galactose 同时阻碍体内糖蛋白的集中化作用。
T37367	Amyloid-β (1-42) Peptide (trifluoroacetate salt)	Others	Others
	Amyloid-β (1-42) (Aβ42) is a neurotoxic 42-amino acid protein fragment found in amyloid plaques in postmortem cerebral cortex from patients with Alzheimer's disease.1,2,3Aggregation of Aβ42 results in the formation of neurotoxic fibrils or globular oligomers.1Aβ42 accumulates in the brain of many transgenic mouse models of Alzheimer's disease and, in many models, the onset of amyloid deposition positively correlates with deficits in spatial learning and memory.4 1.Wolfe, M.S.Therapeutic strategi...
T76361	[DPro5] Corticotropin Releasing Factor, human, rat
	[DPro5] Corticotropin Releasing Factor, human, rat 是人类和大鼠促肾上腺皮质激素释放因子/激素 R2 的选择性激动剂。作为一种下丘脑激素，促肾上腺皮质激素释放因子 (CRF) 能够促进肾上腺皮质激素 (ACTH) 和 β-内啡肽的分泌。值得注意的是，[DPro5] Corticotropin Releasing Factor, human, rat 并不触发典型的焦虑反应，而是能调控大鼠的学习与记忆过程。
T21857	AR-R 17779 hydrochloride	Others	Others
	AR-R17779 hydrochloride 是一种有效和选择性的 nAChR 完全激动剂，对α7和α4β2亚型的Ki 直分别为 92 和 16000 nM。AR-R17779 hydrochloride 可以改善大鼠的学习和记忆能力。AR-R17779 hydrochloride 也具有抗焦虑活性。AR-R17779 hydrochloride 可通过激活抗炎胆碱能（迷走神经）通路减轻炎症。
T84890	Yhhu-3792 hydrochloride	Others	Others
	Yhhu-3792 hydrochloride 增强NSC的自我更新能力，通过激活Notch信号通路并促进Hes3及Hes5的表达，扩大NSC池。此外，Yhhu-3792 hydrochloride促进了小鼠海马齿状回（DG）部分的内源性神经形成，提高小鼠的空间和情景记忆能力，显示出研究记忆障碍相关DG功能障碍的潜力。
T60911	SSTR4 agonist 4	Others	Others
	SSTR4 agonist 4 是一种有效的SSTR4激动剂，具有用于疼痛研究的潜力。SSTR4 激动剂在与急性和慢性相关的抗外周伤害感受和抗炎活性相关疼痛的啮齿动物模型中有效。SSTR4 在海马和新皮质、记忆和学习区域以及阿尔茨海默病病理学中的表达水平相对较高。
T38100	Betamethasone 21-phosphate (sodium salt hydrate)	Others	Others
	Betamethasone 21-phosphate is a synthetic glucocorticoid.1It prevents increases in macrophage and eosinophil numbers in bronchoalveolar lavage fluid (BALF) and decreases in blood leukocyte numbers in a guinea pig model of parainfluenza-3 viral infection when administered at a dose of 8 mg/kg but does not prevent airway hyperresponsiveness after infection.2Betamethasone 21-phosphate inhibits cell infiltration into the aqueous humor in a rat model of endotoxin-induced uveitis when administered top...
T37800	PF-04449613	Others	Others
	PF-04449613 is a phosphodiesterase 9A (PDE9A) inhibitor (IC50= 22 nM).1It is selective for PDE9A over PDE1C (IC50= >1,000 nM), as well as over a variety of other PDEs, inhibiting PDE2-8, -10, and -11 activity by less than 30% in a panel of enzymes, ion channels, and transporters at 1 μM but does inhibit the human dopamine transporter (DAT; Ki= 293 nM). PF-04449613 (0.1-100 mg/kg, s.c.) increases cerebrospinal fluid (CSF) levels of cyclic GMP (cGMP) in rats. Subcutaneous administration of PF-0444...
T37370	Amyloid-β (25-35) Peptide (human) (trifluoroacetate salt)
	Amyloid-β (25-35) (Aβ (25-35)) is an 11-residue fragment of the Aβ protein that retains the physical and biological characteristics of the full length peptide. It forms fibrils that react to thioflavin T and Congo red and are organized in a cross-β arrangement of β-strands similar to Aβ (1-40) and Aβ (1-42) fibrils. Aggregated Aβ (25-35) decreases the viability of rat adrenal PC12 cells. It also decreases the viability of primary rat cortical neurons at concentrations ranging from 1 nM to 30 μM....

化合物

Cat.No: T21793

Target: GABA Receptor

Cat.No: T2301

Synonym: FHPI,SB202190

Target: Apoptosis, p38 MAPK, Autophagy

Cat.No: T21715

Target: HDAC

Cat.No: T30579

Target: HDAC

Cat.No: T8448

Synonym: ZSET-1446,ST-101

Target: Calcium Channel, AChR

Cat.No: T13452

Synonym: (+)-MCPG

Target: GluR

Cat.No: T25450L

Synonym: GGTI2147 FA,GGTI-2147 FA,GGTI 2147 FA(191102-87-1 Free base)

Target: Others

Cat.No: T4364

Synonym: Aftin 4,Aftin4

Target: Beta Amyloid, Gamma-secretase

Cat.No: T23821

Synonym: BRD-4884,BRD 4884

Target: Others

Uridine-3'-monophosphate (sodium salt)

Cat.No: T37375

Target: Others

Cat.No: T22734

Target: Others

Cat.No: T61669

Target: Others

Cat.No: T38192

Target: Others

Cat.No: T63708

Target: Others

KDS2010 mesylate

Cat.No: T70075

Target: Others

Cat.No: T36809

Target: Others

Cat.No: T71622

Target: Others

Cat.No: T79333

Target: Reactive Oxygen Species

SSTR4 agonist 3

Cat.No: T61130

Target: Others

Cat.No: T76757

2-Deoxy-D-galactose

Cat.No: T83389

Target: Others

Amyloid-β (1-42) Peptide (trifluoroacetate salt)

Cat.No: T37367

Target: Others

[DPro5] Corticotropin Releasing Factor, human, rat

Cat.No: T76361

AR-R 17779 hydrochloride

Cat.No: T21857

Target: Others

Yhhu-3792 hydrochloride

Cat.No: T84890

Target: Others

SSTR4 agonist 4

Cat.No: T60911

Target: Others

Betamethasone 21-phosphate (sodium salt hydrate)

Cat.No: T38100

Target: Others

Cat.No: T37800

Target: Others

Amyloid-β (25-35) Peptide (human) (trifluoroacetate salt)

Cat.No: T37370

Cat. No.	Product Name	Target	Signaling Pathways
T2230	Paeoniflorin 芍药苷,Peoniflorin	HSP; COX	Cytoskeletal Signaling; Immunology/Inflammation; Metabolism; Neuroscience
	Paeoniflorin (Peoniflorin) 是从芍药根中提取的一种蒎烷单萜糖苷，具有抗癌作用、抗氧化应激、抗血小板聚集、血管扩张、降低血液粘度和抗炎活性等多种生物活性。它是一种热休克蛋白诱导剂，通过自噬途径保护 PC12 细胞免受 MPP+和酸性损伤。
T0469	Octopamine hydrochloride 章鱼胺盐酸盐,(±)-p-Octopamine hydrochlorid,(+,-)-Octopamine HCl,章胺盐酸盐	Dopamine Receptor; Endogenous Metabolite; Adrenergic Receptor	GPCR/G Protein; Metabolism; Neuroscience
	Octopamine hydrochloride ((±)-p-Octopamine hydrochlorid) 是一种与去甲肾上腺素结构相关的生物单胺类物质，在无脊椎动物中起着神经调节剂、神经激素和神经递质的作用。它对转染人 alpha2-肾上腺素受体(ARs)的中国仓鼠卵巢细胞 α2-ARs 有刺激作用。它提高糖原分解、糖酵解、糖异生、摄氧量和门脉灌注压。
T2777	Ginsenoside Rg1 Sanchinoside C1,Panaxoside Rg1,Sanchinoside Rg1,人参皂苷Rg1,Panaxoside A,人参皂苷 Rg1,Ginsenoside A2	Apoptosis; Beta Amyloid; NF-κB	Apoptosis; Neuroscience; NF-κB
	Ginsenoside Rg1 (Panaxoside Rg1) 是人参的主要活性成分之一，可减少NF-κB 核易位。它改善认知功能受损，通过降低大脑Aβ水平来发挥作用。
T19274	delta-Valerobetaine Δ-Valerobetaine	Endogenous Metabolite	Metabolism
	delta-Valerobetaine 是一种饮食依赖性肥胖原，是微生物组衍生的代谢物，是三甲胺 N-氧化物 (TMAO) 的前体。delta-Valerobetaine对小鼠的学习和记忆过程有害，可调节抑制性突触传递和神经元网络活动。
TN6218	Vitisin A (+)-Vitisin A	Apoptosis; Antioxidant	Apoptosis; oxidation-reduction
	Vitisin A ((+)-Vitisin A) 是一种可从 Vitis vinifera 根中分离出来的白藜芦醇四聚体，具有抗氧化、抗癌、抗细胞凋亡、神经保护和抗炎活性，可改善东莨菪碱诱导的失忆 ICR 小鼠的学习和记忆功能受损，可用于研究退行性疾病。

天然产物

Cat.No: T2230

Synonym: 芍药苷,Peoniflorin

Target: HSP, COX

Octopamine hydrochloride

Cat.No: T0469

Synonym: 章鱼胺盐酸盐,(±)-p-Octopamine hydrochlorid,(+,-)-Octopamine HCl,章胺盐酸盐

Target: Dopamine Receptor, Endogenous Metabolite, Adrenergic Receptor

Ginsenoside Rg1

Cat.No: T2777

Synonym: Sanchinoside C1,Panaxoside Rg1,Sanchinoside Rg1,人参皂苷Rg1,Panaxoside A,人参皂苷 Rg1,Ginsenoside A2

Target: Apoptosis, Beta Amyloid, NF-κB

delta-Valerobetaine

Cat.No: T19274

Synonym: Δ-Valerobetaine

Target: Endogenous Metabolite

Cat.No: TN6218

Synonym: (+)-Vitisin A

Target: Apoptosis, Antioxidant

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPH-01764	Neuropeptide B Protein, Human, Recombinant (GST) Neuropeptide B,Preproprotein L7,NPB	Human	E. coli
	May be involved in the regulation of feeding, neuroendocrine system, memory, learning and in the afferent pain pathway. Neuropeptide B Protein, Human, Recombinant (GST) is expressed in E. coli expression system with N-GST tag. The predicted molecular weight is 29.5 kDa and the accession number is Q8NG41.
TMPH-01281	ELAVL3 Protein, Human, Recombinant (His) PLE21,Hu-antigen C,ELAVL3,ELAV-like protein 3,HUC	Human	P. pastoris (Yeast)
	RNA-binding protein that binds to AU-rich element (ARE) sequences of target mRNAs, including VEGF mRNA. May also bind poly-A tracts via RRM 3. May be involved in neuronal differentiation and maintenance. Plays a role in the stabilization of GAP43 mRNA and in spatial learning.
TMPH-01765	Neuropeptide B Protein, Human, Recombinant Preproprotein L7,NPB,Neuropeptide B	Human	E. coli
	May be involved in the regulation of feeding, neuroendocrine system, memory, learning and in the afferent pain pathway. Neuropeptide B Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 3.1 kDa and the accession number is Q8NG41.
TMPH-01770	Neurotrypsin Protein, Human, Recombinant (His & SUMO) PRSS12,Motopsin,Serine protease 12,Leydin,Neurotrypsin	Human	E. coli
	Plays a role in neuronal plasticity and the proteolytic action may subserve structural reorganizations associated with learning and memory operations. Neurotrypsin Protein, Human, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 43.4 kDa and the accession number is P56730.
TMPY-06864	GLP1R Protein, Human, Recombinant (His & Avi) glucagon-like peptide 1 receptor	Human	HEK293 Cells
	Glucagon-like peptide (GLP)-1 receptor is encoded by GLP1R. GLP1R plays a critical role in mediating the biological actions of GLP1 in mammals and fish. The neuronal GLP1Rs mediate body weight and anorectic effects of liraglutide, but are not required for glucose-lowering effects. Glucagon-like peptide 1 receptor (GLP1R) signaling has been shown to have antipsychotic properties in animal models and to impact glucose-dependent insulin release, satiety, memory, and learning in man. Glucagon-like p...
TMPY-04373	CAMKII alpha/CAMK2A Protein, Human, Recombinant (GST) calcium/calmodulin-dependent protein kinase II alpha,calcium...	Human	Baculovirus Insect Cells
	Ca2+/calmodulin-dependent protein kinase2A (CAMK2A) belongs to the serine/threonine protein kinase family and, together with other 28 different isoforms, belongs to the Ca2+/ calmodulin-dependent protein kinase subfamily. CaM kinase Ⅱ is thought to be an important mediator of learning and memory and is also necessary for Ca2+homeostasis and reuptake in cardiomyocytes chloride transport in epithelia, positive T-cell selection, and CD8 T-cell activation. CAMKIIA is one of the major forms of CAMKII...
TMPJ-00007	NPY Protein, Human, Recombinant (His) Pro-Neuropeptide Y,Neuropeptide Y,NPY,C-Flanking Peptide of ...	Human	HEK293 Cells
	Pro-Neuropeptide Y (NPY) is a member of the NPY family. NPY is a secreted protein and is one of the most abundant peptides in the nervous system. It also can be found in some chromaffin cells of the adrenal medulla. NPY can be cleaved into Neuropeptide Y and C-flanking peptide of NPY chain, which regulates energy usage, and it is involved in learning, memory processing, and epilepsy. NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone. In addition, NPY i...
TMPY-04318	GRIK2 Protein, Human, Recombinant (hFc) GLUR6,EAA4,MRT6,GLR6,glutamate receptor, ionotropic, kainate...	Human	HEK293 Cells
	GRIK2 (Glutamate Ionotropic Receptor Kainate Type Subunit 2, also known as GluR6) is a Protein Coding gene. The GRIK2 (one of the kainate receptors) gene resides in a genetic linkage region (6q21) associated with bipolar disorder (BPD). The gene coding for GRIK2 has been suggested as a candidate gene for autism based on its localization in the autism-specific region on chromosome 6q21 and the involvement of receptor protein in cognitive functions like learning and memory. GRIK2 belongs to the gl...
TMPJ-01112	PRKG1 Protein, Human, Recombinant (His) PRKGR1B,PRKG1B,cGKI,cGMP-Dependent Protein Kinase 1,cGK1,cGK...	Human	HEK293 Cells
	cGMP-Dependent Protein Kinase 1 (PRKG1) belongs to the protein kinase superfamily and AGC Ser/Thr protein kinase family. PRKG1 contains one AGC-kinase C-terminal domain, two cyclic nucleotide-binding domains, and one protein kinase domain. PRKG1 is mainly expressed in the lung and placenta. PRKG1 acts as a key mediator of the nitric oxide (NO)/cGMP signaling pathway. PRKG1 can phosphorylate many proteins that regulate platelet activation and adhesion, smooth muscle contraction, cardiac function,...
TMPY-02977	PDE1C Protein, Human, Recombinant (His & GST) hCam-3,phosphodiesterase 1C, calmodulin-dependent 70kDa,cam-...	Human	Baculovirus Insect Cells
	PDE1C belongs to the cyclic nucleotide phosphodiesterase family, PDE1 subfamily. Phosphodiesterases (PDEs) are a family of related phosphohydrolyases that selectively catalyze the hydrolysis of 3' cyclic phosphate bonds in adenosine and/or guanine 3',5' cyclic monophosphate (cAMP and/or cGMP). They regulate the cellular levels, localization and duration of action of these second messengers by controlling the rate of their degradation. PDEs are expressed ubiquitously, with each subtype having a s...
TMPJ-00782	Amyloid Precursor Protein, Human, Recombinant (hFc) Amyloid Precursor,Amyloid Precursor Protein 695,APP695	Human	HEK293 Cells
	Amyloid precursor protein (APP) is a type I membrane protein with several isoforms due to alternative splicing, performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Of the three major splice isoforms of APP (APP695, APP751, and APP770) APP695 is the predominant neuronal form from which Amyloid beta peptide and transcriptionally-active cleaved intracellular domain of APP (AICD) are preferentially generated by selective process...
TMPY-01692	NETO1 Protein, Human, Recombinant (His) neuropilin (NRP) and tolloid (TLL)-like 1,BCTL1,BTCL1	Human	HEK293 Cells
	Neuropilin tolloid-like 1 (NETO1), a complement C1r/C1s, Uegf, Bmp1 (CUB) domain-containing transmembrane protein, is a novel component of the NMDAR complex critical for maintaining the abundance of NR2A-containing NMDARs in the postsynaptic density. The N-methyl-D-aspartate receptor (NMDAR), a major excitatory ligand-gated ion channel in the central nervous system (CNS), is a principal mediator of synaptic plasticity. Both NETO1 and NETO2 share an identical and unique domain structure thus repr...
TMPH-02317	YTHDF1 Protein, Human, Recombinant (His) YTHDF1,Dermatomyositis associated with cancer putative autoa...	Human	P. pastoris (Yeast)
	Specifically recognizes and binds N6-methyladenosine (m6A)-containing mRNAs, and regulates their stability. M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in mRNA stability and processing. Acts as a regulator of mRNA stability by promoting degradation of m6A-containing mRNAs via interaction with the CCR4-NOT complex. The YTHDF paralogs (YTHDF1, YTHDF2 and YTHDF3) shares m6A-containing mRNAs targets and act redundantly to mediate mRNA degradatio...
TMPH-01282	ELAVL4 Protein, Human, Recombinant (His & Myc & SUMO) PNEM,ELAVL4,HuD,Hu-antigen D,ELAV-like protein 4	Human	E. coli
	RNA-binding protein that is involved in the post-transcriptional regulation of mRNAs. Plays a role in the regulation of mRNA stability, alternative splicing and translation. Binds to AU-rich element (ARE) sequences in the 3' untranslated region (UTR) of target mRNAs, including GAP43, VEGF, FOS, CDKN1A and ACHE mRNA. Many of the target mRNAs are coding for RNA-binding proteins, transcription factors and proteins involved in RNA processing and/or neuronal development and function. By binding to th...

重组蛋白

Neuropeptide B Protein, Human, Recombinant (GST)

Cat.No: TMPH-01764

Species: Human

Expression System: E. coli

ELAVL3 Protein, Human, Recombinant (His)

Cat.No: TMPH-01281

Species: Human

Expression System: P. pastoris (Yeast)

Neuropeptide B Protein, Human, Recombinant

Cat.No: TMPH-01765

Species: Human

Expression System: E. coli

Neurotrypsin Protein, Human, Recombinant (His & SUMO)

Cat.No: TMPH-01770

Species: Human

Expression System: E. coli

GLP1R Protein, Human, Recombinant (His & Avi)

Cat.No: TMPY-06864

Species: Human

Expression System: HEK293 Cells

CAMKII alpha/CAMK2A Protein, Human, Recombinant (GST)

Cat.No: TMPY-04373

Species: Human

Expression System: Baculovirus Insect Cells

NPY Protein, Human, Recombinant (His)

Cat.No: TMPJ-00007

Species: Human

Expression System: HEK293 Cells

GRIK2 Protein, Human, Recombinant (hFc)

Cat.No: TMPY-04318

Species: Human

Expression System: HEK293 Cells

PRKG1 Protein, Human, Recombinant (His)

Cat.No: TMPJ-01112

Species: Human

Expression System: HEK293 Cells

PDE1C Protein, Human, Recombinant (His & GST)

Cat.No: TMPY-02977

Species: Human

Expression System: Baculovirus Insect Cells

Amyloid Precursor Protein, Human, Recombinant (hFc)

Cat.No: TMPJ-00782

Species: Human

Expression System: HEK293 Cells

NETO1 Protein, Human, Recombinant (His)

Cat.No: TMPY-01692

Species: Human

Expression System: HEK293 Cells

YTHDF1 Protein, Human, Recombinant (His)

Cat.No: TMPH-02317

Species: Human

Expression System: P. pastoris (Yeast)

ELAVL4 Protein, Human, Recombinant (His & Myc & SUMO)

Cat.No: TMPH-01282

Species: Human

Expression System: E. coli

Cat. No.	Product Name	Target	Signaling Pathways
T71142	Tebuconazole-d9
	Tebuconazole-d9 is intended for use as an internal standard for the quantification of tebuconazole by GC- or LC-MS. Tebuconazole is a triazole fungicide that is active against both seed and foliar fungi. It inhibits 14α-demethylase isolated from U. maydis and S. bicolor with IC50 values of 0.05 and 0.16 nM, respectively. It inhibits the androgenic effect of the androgen receptor agonist DHT (IC20 = 2.89 µM) and is cytotoxic (EC20 = 38.9 µM) in an MDA-kb2 assay. Tebuconazole (50 and 100 mg/kg per...

同位素标记化合物

Tebuconazole-d9

Cat.No: T71142

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