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Search Results for " intrinsic "

Targets Recommended: Adrenergic Receptor

63

抑制剂 & 化合物

16

天然产物

2

化合物库

17

重组蛋白

4

同位素标记化合物

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Cat. No.	Product Name
L7700	神经再生化合物库		524 compounds
	524 种神经再生相关化合物的独特集合，可用于高通量筛选和高内涵筛选；
L5100	含氟化合物库		574 compounds
	574 个含氟化合物的独特集合，可用于高通量筛选和高内涵筛选；

化合物库

神经再生化合物库

Cat.No: L7700

Compounds: 524

含氟化合物库

Cat.No: L5100

Compounds: 574

Cat. No.	Product Name	Target	Signaling Pathways
T8580	Bupranolol	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Bupranolol 是竞争性的、口服活性的、非选择性的β-adrenoceptor 拮抗剂，无固有的拟交感神经活性。
T1944	LDN-214117	ALK; TGF-beta/Smad	Angiogenesis; Stem Cells; Tyrosine Kinase/Adaptors
	LDN214117 是一种高效的 ALK2 选择性抑制剂(IC50:22nM)，也是一种 BMP6 抑制剂(IC50:100nM)，对ALK5抑制力弱100倍。
T24381	L-822179 L822179,L 822,179,L 822179,L822,179,L-822,179	GABA Receptor	Membrane transporter/Ion channel; Neuroscience
	L-822179 (α5IA) 是 GABAA 受体 Α5 亚型的选择性反向激动剂，在 A5 亚型中具有比其他药物更高的内在活性。
T10631L	Bucindolol Formate Bucindolol Formate (71119-11-4 Free base)	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Bucindolol Formate 是一种具有内源性拟交感活性的β1 肾上腺素能受体 (β1-adrenergic receptor) 阻滞剂。Bucindolol 可用于心力衰竭疾病研究。
T38563	Raptinal	Caspase	Apoptosis; Proteases/Proteasome
	Raptinal 直接激活 caspase-3 并在多种细胞系中启动内在的 caspase 依赖性细胞凋亡途径。
T22128	OU749	Transferase	Metabolism
	OU749 是一种 γ-谷氨酰转移酶 (GGT) 抑制剂，固有 Ki 值为 17.6 μM。
T0342	Carvedilol phosphate hemihydrate Carvedilol phosphate,BM 14190 (phosphate hemihydrate),卡维地洛磷酸盐	VEGFR; Others; Potassium Channel; LDL; Integrin; Gap Junction Protein; NADPH; Adrenergic Receptor; Autophagy	Angiogenesis; Autophagy; Cytoskeletal Signaling; GPCR/G Protein; Membrane transporter/Ion channel; Metabolism; Neuroscience; Others; Tyrosine Kinase/Adaptors
	Carvedilol phosphate hemihydrate (BM 14190 phosphate hemihydrate) 是一种外消旋混合物，是一种非选择性β/α-1受体阻断剂，具有抗高血压活性且缺乏内在拟交感神经活性。
T28124	N106 N-106,N 106	E1/E2/E3 Enzyme	Ubiquitination
	N106 是 SUMO 激活酶 E1 连接酶的激活剂，并触发 SERCA2a 的内在 sumoylation。 N106 可用于有关心力衰竭的研究。
T6191	Tasisulam LY573636,他司磺胺	Apoptosis; Caspase	Apoptosis; Proteases/Proteasome
	Tasisulam (LY573636) 是一种小分子抗肿瘤药物，通过内在途径诱导细胞凋亡，导致细胞色素 c 释放和 caspase 依赖性细胞死亡。它抑制有丝分裂进程并诱导血管正常化。
T67917	ML353 VU0478006	Potassium Channel	Membrane transporter/Ion channel
	ML353 (VU0478006)是 TREK-1和 TREK-2的选择性激活剂，是 mGlu5 沉默变构调节剂 (SAM) 的选择性配体(Ki =18.2 nM)。 ML353 有作为解决 SAM 体内固有活性或药物阻断的潜力。
T9014	SKI-178	Apoptosis; S1P Receptor	Apoptosis; GPCR/G Protein
	SKI-178 是一种鞘氨醇激酶-1(SphK1)和 SphK2抑制剂，以 CDK1 依赖性方式诱导人急性髓性白血病细胞凋亡。
T1282	Carteolol hydrochloride Arteoptic,Abbott-43326,OPC-1085 hydrochloride,盐酸卡替洛尔,Carteolol HCl,Mikelan	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Carteolol hydrochloride (Abbott-43326) 是一种非选择性的β肾上腺素受体阻断剂。
T1012	Acebutolol hydrochloride 盐酸醋丁洛尔,Acebutolol HCl	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Acebutolol hydrochloride (Acebutolol HCl) 是一种 β-肾上腺素受体拮抗剂，用于研究高血压、心绞痛和心律失常。
T9836	(E)-SI-2	Others	Others
	(E)-SI-2 是类固醇受体 coactivator-3（SRC-3 或 AIB1）的有效小分子抑制剂，可选择性抑制 SRC-3 的内在转录活性，也抑制 SRC-1 和 SRC-2。它选择性地降低 SRC-3 的细胞蛋白水平，但不降低 CARM-1 的细胞蛋白水平，阻断 MDA-MB-468 细胞生长，IC50 值为 3.4 nM，但不影响正常细胞。
T26762	Befunolol HCl BFE60,Bentox,Befunolol hydrochloride,BFE-60,BFE 60	Others	Others
	Befunolol is a beta blocker with intrinsic sympathomimetic activity and also acts as a β adrenoreceptor partial agonist.
T8456	GALNON	Neuropeptide Y Receptor	GPCR/G Protein; Neuroscience
	Galnon 是一种甘丙肽受体激动剂，可改善内在的皮质骨组织特性。
T5450	DL-071-IT Afurolol Hydrochloride,DL 071 IT	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	DL-071-IT (Afurolol Hydrochloride) 是一种有效的非选择性β-肾上腺素受体拮抗剂。 DL-071-IT 表现出内在的拟交感神经活性和弱的膜稳定活性。
T75688	1-Stearoyl-2-arachidonoyl-sn-glycero-3-phosphoinositol	Others	Others
	1-Stearoyl-2-arachidonoyl-sn-glycero-3-phosphoinositol 是一种内源性代谢物，是细胞膜成分。
T40658	[D-Asn5]-Oxytocin [D-Asn5]-Oxytocin
	[D-Asn5]-Oxytocin exhibits minimal specific oxytocic and vasodepressor effects. Comparative cumulative dose-response investigations reveal that [D-Asn5]-Oxytocin demonstrates a similar intrinsic activity to oxytocin in terms of oxytocic activity.
T40596	Tasisulam sodium LY 573636 sodium,Tasisulam sodium	Others	Others
	Tasisulam is an anti-cancer compound that induces apoptosis through the intrinsic pathway, leading to the release of cytochrome c and caspase-dependent cell death. Additionally, tasisulam inhibits mitotic progression and triggers vascular normalization.
T79921	Moloney murine leukemia virus RT	DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	Moloney murine leukemia virus RT为源自Moloney小鼠白血病病毒的逆转录酶，作为复制聚合酶在逆转录病毒生命周期中扮演关键角色。
T36928	ICI 215,001 hydrochloride	Others	Others
	ICI 215,001 hydrochloride 在其内在激动剂活性较低的情况下可充当 β1 和 β2 肾上腺素受体的拮抗剂。
T1244	Celiprolol hydrochloride Selecor,Selectrol,盐酸塞利洛尔	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Celiprolol hydrochloride (Selectrol) 是一种选择性肾上腺素受体调节剂，是一种选择性的和具有口服活性的β1肾上腺素受体拮抗剂，具有部分β2激动剂活性，具有降压和抗心绞痛的作用。
T0143	Bisoprolol hemifumarate 富马酸比索洛尔,(±)-Bisoprolol hemifumarate,Bisoprolol fumarate,Bisoprolol hemifumarate salt,EMD33512,(±)-Bisoprolol (hemifumarate)	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Bisoprolol hemifumarate 是一种 β1 肾上腺素受体阻断剂。
T35947	17(S)-HDHA	Others	Others
	17(S)-HDHA is a primary mono-oxygenation product of docosahexaenoic acid in human whole blood, human leukocytes, and mouse brain. 17(S)-HDHA serves as a precursor to 17(S)-resolvins and has intrinsic biological activity, such as the inhibition of TNF-α-induced interleukin-1β expression in human glioma cells and inhibition of TNF-α-induced leukocyte trafficking to the mouse air pouch.
T62814	Antitumor agent-77	Others	Others
	Antitumor agent-77 对癌细胞的生长和迁移具有抑制作用，具有抗癌作用。Antitumor agent-77 能够抑制 GPx-4 和提高 COX2 引发铁下垂。Antitumor agent-77 可以激活肿瘤细胞固有凋亡通路 (Bax-Bcl-2-caspase-3)，阻碍肿瘤细胞上皮间质转化 (EMT) 过程。
T73778	cis-5-Tetradecenoic acid	Others	Others
	cis-5-Tetradecenoic acid，一种存在于血液中的内源性代谢物，主要用于研究长链3羟酰基CoA脱氢酶缺乏症。
T60553	Tetrahydrouridine dihydrate	Others	Others
	Tetrahydrouridine dihydrate (THU dihydrate) 是有效的胞苷脱氨酶抑制剂。Tetrahydrouridine dihydrate 比内在胞苷更有效地竞争性阻断酶的活性位点。
TP2126	R 892
	Potent and selective bradykinin B1 receptor antagonist (ID50 values are 2.8 and > 600 nM at B1 and B2 receptors respectively). Exhibits no intrinsic agonist activity and is resistant to aminopeptidase and kininase II (ACE) cleavage. Displays hypertensive
T76214	5′-Nucleotidase	Others	Others
	5′-Nucleotidase (CD73) 是一种作为胞外酶存在的内在膜糖蛋白。5′-Nucleotidase 催化 5-核苷酸水解成相应的核苷。
T68869	TP-110	Others	Others
	TP-110 is a new proteasome inhibitor, which shows potent growth inhibition in various tumor cell lines. Treatment with TP-110 for 24 h in vitro induced apoptosis in multiple myeloma cell line RPMI8226. TP-110 reduced the intrinsic inhibitor of apoptosis proteins (IAPs), cIAP-1 and XIAP, that suppress executioner caspases.
T38099	APF
	APF is an aromatic amino-fluorescein derivative and fluorescent probe for highly reactive radicals. It has low intrinsic fluorescence, however, upon oxidation by hydroxyl radical, hypochlorite ion, and certain peroxidase intermediates, it is converted to the highly fluorescent molecule fluorescein, facilitating the detection of highly reactive biological radicals. APF is not oxidized by nitric oxide (NO), hydrogen peroxide (H2O2), or other oxidants. Fluorescein displays excitation/emission maxim...
T36042	17(R)-HDHA	Others	Others
	Resolvins are a group of polyhydroxylated metabolites of docosahexaenoic acid (DHA) found in the inflammatory exudates of aspirin-treated experimental animals. 17(R)-HDHA is the primary oxygenation product of DHA when exposed to aspirin-inhibited cyclooxygenase-2. 17(R)-HDHA serves as a precursor to resolvins and has intrinsic biological activity, such as the inhibition of TNFα-induced IL-1β expression in human glioma cells.
T60756	NLRP3 antagonist 1	Others	Others
	NLRP3 antagonist 1 具有癌症疾病的研究潜力，是NLRP3的有效拮抗剂。NLRP3 参与机体对应激损伤和病原体感染的内在免疫，主要表达在巨噬细胞和中性粒细胞。
T60990	U92016A hydrochloride	Others	Others
	U92016A hydrochloride 是口服有效的5-HT1A 受体激动剂，代谢稳定。U92016A hydrochloride 表现出极高的内在活性，能够以高亲和力结合中国仓鼠卵巢细胞中表达的人 5-HT1A 受体，Ki 值为0.2 nM。
T85194	N-Deacetylcolchicine NSC 201400	Others	Others
	Trimethylcolchicinic acid methyl ether (HAN 76504), an antimitotic agent, blocks microtubule assembly by attaching to tubulin and inhibiting its polymerization. It enhances tubulin's intrinsic GTPase activity, induces apoptosis across various normal and tumor cell lines, and activates the JNK/SAPK pathway. Currently unnamed, it is referred to by a provisional code name in line with MedKoo Chemical Nomenclature (https://www.medkoo.com/page/naming) for ease of communication.
T62850	IRAK4-IN-13	Others	Others
	IRAK4-IN-13 (compound 21) 是一种选择性的、有效的 IRAK4 抑制剂 (IC50: 0.6 nM)。IRAK4-IN-13 具有高代谢清除率，人肝微粒体 (HLM) 固有清除率为 96 μL/min/mg。
T84919	M4K2163 dihydrochloride	Others	Others
	M4K2163二盐酸盐是一种高效、选择性的ALK2抑制剂，具有血脑屏障(BBB)渗透能力，IC50为19 nM。该化合物主要用于弥漫性内源性脑桥胶质瘤(DIPG)的研究。
T71033	ZD7114 free base	Others	Others
	ZD7114, also known as ICI-D7114, is a selective adrenoceptor agonist of brown fat and thermogenesis. ICI D7114 stimulates thermogenesis at doses that have little effect on beta 1 or beta 2 adrenoceptors. Treatment with ICI D7114 activates BAT and thermogenesis even in species and situations where the intrinsic capacity is low. ICI D7114 has beneficial effects in animal models of obesity and disturbed glucose and lipid homeostasis.
T63262	IRAK4-IN-15	Others	Others
	IRAK4-IN-15 是选择性的、有效的 IRAK4 抑制剂 (IC50: 0.002 μM)，具有良好的人类 PK 预测且具有低内在清除率。IRAK4-IN-15 与 Acalabrutinib 联用对 MyD88/CD79 双突变体 ABC-DLBCL 的表现出强大的协同体外活性。
T84648	2-Linoleoyl Glycerol 2-LG	Others	Others
	2-Arachidonoyl glycerol (2-AG), a natural endocannabinoid ligand for the CB1 receptor, was isolated from porcine brain and characterized. Its congener, 2-linoleoyl glycerol (2-LG), which has a linoleoyl group instead of an arachidonoyl group, also exists alongside 2-AG in vivo. While 2-LG exhibits low intrinsic activity, it enhances the activity of 2-AG and other endocannabinoids through an "entourage" effect, attributed to the inhibition of breakdown and reuptake pathways that typically decreas...
T71284	Glimepiride urethane	Others	Others
	Glimepiride urethane is a third generation sulfonylurea compound, which increases the release of insulin from pancreatic beta cells. In addition, glimepiride increases the activity of intracellular insulin receptors. Glimepiride increases osteoblast proliferation and differentiation, which is thought to be related to its ability to activate the PI3K and Akt pathway. Furthermore, Glimepiride enhances intrinsic peroxisome proliferator-activated receptor γ activity. Glimepiride also increases prote...
T80963	TPEQM-DMA
	TPEQM-DMA为近红外二区光敏剂，能在癌性线粒体中积累，抑制癌细胞生长。其显著I型光疗效果，有助于克服光动力疗法(PDT)治疗低氧肿瘤的限制。
T28449	Pradefovir ICN-2001-3,MB-6866,帕拉德福韦,ICN-20013,MB-06866,Remofovir	HBV	Microbiology/Virology
	Pradefovir (Remofovir) 是一种逆转录酶抑制剂，可能用于治疗慢性 HBV 感染。它也是阿德福韦的肝脏靶向前药。代谢激活后，它在人肝微粒体中转化为 PMEA(9-(2-膦酰基甲氧基乙基)腺嘌呤)，Km 为 60 microM，最大代谢速率为 228 pmol/min/mg 蛋白质，以及内在的清除率约为 359 ml/min。
T84457	DC4 Crosslinker	Others	Others
	DC4 crosslinker, an 18Å mass spectrometry-cleavable crosslinking reagent, features two intrinsic positive charges facilitating the fragmentation of cross-linked peptides into their constituent peptides through collision-induced dissociation or in-source decay. Initial fragmentation leads to cleavage adjacent to the positive charges, enabling the identification of cross-linked peptides as pairs of ions with precise mass separation. Furthermore, the resultant intact peptide fragments can undergo f...
T84891	TM5441 sodium	Others	Others
	TM5441是一种口服生物可利用的PAI-1(纤溶酶原激活物抑制剂-1)抑制剂，其对多种癌症细胞系的IC50值介于13.9到51.1μM之间，能诱导人类癌症细胞的内在凋亡(apoptosis)。此外，TM5441还可减轻Nω-硝基-1-精氨酸甲酯引发的心脏高血压和血管老化。
T70352	PH11	Others	Others
	PH11 is a novel Focal Adhesion Kinase (FAK) inhibitor. PH11 restores TRAIL apoptotic pathway in PANC-1 cells through down-regulation of c-FLIP via inhibition of FAK and the phosphatidylinositol-3 kinase (PI3K)/AKT pathways. Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) emerges as one of the most-promising experimental cancer therapeutic drugs and is currently being tested in clinical trials. However, both intrinsic and acquired resistance of human cancer cells to TRAIL...
T70506	Bupranolol HCl	Others	Others
	Bupranolol is a non-selective beta blocker without intrinsic sympathomimetic activity (ISA), but with strong membrane stabilizing activity. Its potency is similar to propranolol. Bupranolol is quickly and completely absorbed from the gut. Over 90% undergo first-pass metabolism. Bupranolol has a plasma half life of about two to four hours, with levels never reaching 1 µg/l in therapeutic doses. The main metabolite is carboxybupranolol, 4-chloro-3-[3-(1,1-dimethylethylamino)-2-hydroxy-propyloxy]be...
T78877	MTX-241F	EGFR	Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	MTX-241F是一种选择性小分子抑制剂，针对EGFR和PI3激酶家族。其具备穿透血脑屏障的能力，能够持续控制肿瘤生长。在来源于患者的DIPG神经球中，MTX-241F展示了与放射疗法协同增效的特性，适用于研究弥漫性内源性桥脑胶质瘤(DIPG)。
T84653	17-phenyl trinor Prostaglandin F2α diethyl amide Bimatoprost diethyl amide	Others	Others
	17-Phenyl trinor Prostaglandin F2αdiethyl amide (17-phenyl trinor PGF2αdiethyl amide) is a Prostaglandin F2α(PGF2α) analog characterized by the substitution of the C-1 carboxyl group with an N-diethyl amide. Prostaglandin (PG) esters and N-ethyl amides have demonstrated ocular hypotensive properties, with N-ethyl amides introduced as alternative options for PG hypotensive prodrugs. Studies indicate that both bovine and human corneal tissues can convert N-ethyl amides of various PGs into their fr...

化合物

Cat.No: T8580

Target: Adrenergic Receptor

Cat.No: T1944

Target: ALK, TGF-beta/Smad

Cat.No: T24381

Synonym: L822179,L 822,179,L 822179,L822,179,L-822,179

Target: GABA Receptor

Bucindolol Formate

Cat.No: T10631L

Synonym: Bucindolol Formate (71119-11-4 Free base)

Target: Adrenergic Receptor

Cat.No: T38563

Target: Caspase

Cat.No: T22128

Target: Transferase

Carvedilol phosphate hemihydrate

Cat.No: T0342

Synonym: Carvedilol phosphate,BM 14190 (phosphate hemihydrate),卡维地洛磷酸盐

Target: VEGFR, Others, Potassium Channel, LDL, Integrin, Gap Junction Protein, NADPH, Adrenergic Receptor, Autophagy

Cat.No: T28124

Synonym: N-106,N 106

Target: E1/E2/E3 Enzyme

Cat.No: T6191

Synonym: LY573636,他司磺胺

Target: Apoptosis, Caspase

Cat.No: T67917

Synonym: VU0478006

Target: Potassium Channel

Cat.No: T9014

Target: Apoptosis, S1P Receptor

Carteolol hydrochloride

Cat.No: T1282

Synonym: Arteoptic,Abbott-43326,OPC-1085 hydrochloride,盐酸卡替洛尔,Carteolol HCl,Mikelan

Target: Adrenergic Receptor

Acebutolol hydrochloride

Cat.No: T1012

Synonym: 盐酸醋丁洛尔,Acebutolol HCl

Target: Adrenergic Receptor

Cat.No: T9836

Target: Others

Cat.No: T26762

Synonym: BFE60,Bentox,Befunolol hydrochloride,BFE-60,BFE 60

Target: Others

Cat.No: T8456

Target: Neuropeptide Y Receptor

Cat.No: T5450

Synonym: Afurolol Hydrochloride,DL 071 IT

Target: Adrenergic Receptor

1-Stearoyl-2-arachidonoyl-sn-glycero-3-phosphoinositol

Cat.No: T75688

Target: Others

[D-Asn5]-Oxytocin

Cat.No: T40658

Synonym: [D-Asn5]-Oxytocin

Tasisulam sodium

Cat.No: T40596

Synonym: LY 573636 sodium,Tasisulam sodium

Target: Others

Moloney murine leukemia virus RT

Cat.No: T79921

Target: DNA/RNA Synthesis

ICI 215,001 hydrochloride

Cat.No: T36928

Target: Others

Celiprolol hydrochloride

Cat.No: T1244

Synonym: Selecor,Selectrol,盐酸塞利洛尔

Target: Adrenergic Receptor

Bisoprolol hemifumarate

Cat.No: T0143

Synonym: 富马酸比索洛尔,(±)-Bisoprolol hemifumarate,Bisoprolol fumarate,Bisoprolol hemifumarate salt,EMD33512,(±)-Bisoprolol (hemifumarate)

Target: Adrenergic Receptor

Cat.No: T35947

Target: Others

Antitumor agent-77

Cat.No: T62814

Target: Others

cis-5-Tetradecenoic acid

Cat.No: T73778

Target: Others

Tetrahydrouridine dihydrate

Cat.No: T60553

Target: Others

Cat.No: TP2126

5′-Nucleotidase

Cat.No: T76214

Target: Others

Cat.No: T68869

Target: Others

Cat.No: T38099

Cat.No: T36042

Target: Others

NLRP3 antagonist 1

Cat.No: T60756

Target: Others

U92016A hydrochloride

Cat.No: T60990

Target: Others

N-Deacetylcolchicine

Cat.No: T85194

Synonym: NSC 201400

Target: Others

Cat.No: T62850

Target: Others

M4K2163 dihydrochloride

Cat.No: T84919

Target: Others

ZD7114 free base

Cat.No: T71033

Target: Others

Cat.No: T63262

Target: Others

2-Linoleoyl Glycerol

Cat.No: T84648

Synonym: 2-LG

Target: Others

Glimepiride urethane

Cat.No: T71284

Target: Others

Cat.No: T80963

Cat.No: T28449

Synonym: ICN-2001-3,MB-6866,帕拉德福韦,ICN-20013,MB-06866,Remofovir

Target: HBV

DC4 Crosslinker

Cat.No: T84457

Target: Others

Cat.No: T84891

Target: Others

Cat.No: T70352

Target: Others

Cat.No: T70506

Target: Others

Cat.No: T78877

Target: EGFR

17-phenyl trinor Prostaglandin F2α diethyl amide

Cat.No: T84653

Synonym: Bimatoprost diethyl amide

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
TN1019	Beta-mangostin β-Mangostin,beta-倒捻子素	Apoptosis; Antibacterial; Parasite	Apoptosis; Microbiology/Virology
	Beta-mangostin (β-Mangostin) 是存在 Cratoxylum arborescens 中的一种氧杂蒽酮类天然产物，有抗癌和抗菌活性，对结核分枝杆菌的 MIC 值为 6.25 μg/mL。它在体外有抗疟活性，对恶性疟原虫的 IC50值为 3.00 μg/mL。
T3916	Ginsenoside F2 人参皂苷F2	Apoptosis; Endogenous Metabolite; Autophagy	Apoptosis; Autophagy; Metabolism
	Ginsenoside F2 是 Ginsenoside Rb1 的代谢物，通过激活内在的凋亡途径和线粒体功能障碍来诱导乳腺的凋亡，对乳腺癌干细胞具有抗增殖活性。
TN1248	3-Epioleanolic acid	AChR	Neuroscience
	3-Epioleanolic acid 是一种分离自马鞭草的有效成分，具有抗炎作用。
TN2097	Pomolic acid 坡模酸	Apoptosis; Caspase; HIV Protease; AMPK	Apoptosis; Chromatin/Epigenetic; Microbiology/Virology; PI3K/Akt/mTOR signaling; Proteases/Proteasome
	Pomolic acid 是从野鸦椿中分离出来的一种五环三萜烯。它抑制肿瘤细胞的生长，诱导细胞凋亡，有用于前列腺癌的潜力。
T3386	Kaempferitrin Lespedin,Kaempferol,Lespenephryl,Lespenefril,Kaempferol 3,7-dirhamnoside,山奈苷	cell cycle arrest; Glucokinase; IGF-1R	Cell Cycle/Checkpoint; Metabolism; Tyrosine Kinase/Adaptors
	Kaempferitrin (Lespenephryl) 是天然黄酮苷类化合物，具有缓解疼痛、抗糖尿病、消炎、抗肿瘤和化疗作用，可激活胰岛素信号传导。
T4746	Purine 7H-Imidazo(4,5-d)pyrimidine,嘌呤	Others; Endogenous Metabolite	Metabolism; Others
	Purine (7H-Imidazo(4,5-d)pyrimidine) 是内源性代谢产物的一种。
T7032	Eupatorin	Others; P450	Metabolism; Others
	Eupatorin 是天然存在的黄酮，可捕获 G2-M 细胞周期，激活多个 caspase、细胞色素 C 的释放、多聚 (ADP-核糖) 聚合酶的裂解，促使凋亡细胞死亡。
T1040	Vitamin B12 Cyanocobalamin,Cobalamin,维生素B12	Endogenous Metabolite	Metabolism
	Vitamin B12 (Cobalamin) 是一种维生素，在维持血流形成和脑、神经系统正常功能等方面发挥关键作用。
T28122	Myrtenal NSC-54384,NSC 54384,NSC54384,Benihinal
	Myrtenal is a natural monoterpene. It is found to attenuate diethylnitrosamine-induced hepatocellular carcinoma in rats by stabilizing intrinsic antioxidants and modulating apoptotic and anti-apoptotic cascades. Myrtenal also inhibits acetylcholinesterase
TN6059	Demethoxyfumitremorgin C
	Demethoxyfumitremorgin C and tryprostatin B are fungal inhibitors of mammalian cell cycle progression at the G(2)/M transition. Demethoxyfumitremorgin C inhibits the proliferation of PC3 human prostate cancer cells via the intrinsic (mitochondrial) and ex
T78466	Erythronic acid potassium	Endogenous Metabolite	Metabolism
	Erythronic acid potassium为糖类内源性代谢物，关键作用于高尿酸血症发病及改善过程，并与转醛缩酶缺乏症相关的线粒体功能障碍有关，常用于代谢性疾病研究。
T13797	Nivalenol	Caspase	Apoptosis; Proteases/Proteasome
	Nivalenol 是一种由禾谷镰刀菌产生的真菌代谢物。 Nivalenol 通过 caspase 和内在凋亡途径诱导细胞死亡，从而影响免疫系统并引起呕吐、生长迟缓和生殖障碍。
T78471	α,α-Trehalose 6-phosphate potassium Tre6P potassium	Endogenous Metabolite	Metabolism
	α,α-Trehalose 6-phosphate (Tre6P) potassium 是一种α,α′-trehalose的6-磷酸衍生物及内源代谢物。在Tre6P磷酸酶 (T6PP) 的催化下，α,α-Trehalose 6-phosphate可被高效转化为α,α′-trehalose。
T73717	cGAMP diammonium	Others	Others
	cGAMP (Cyclic GMP-AMPP) diammonium 是一种内源性第二信使，通过触发干扰素的产生来响应胞浆 DNA。它通过激活干扰素基因刺激因子（STING），启动信号级联，进而导致I型干扰素及其他免疫介质的生成。
TN4877	Quercetin 3,4'-dimethyl ether	ERK; BCL; MAPK; Caspase; JNK	Apoptosis; MAPK; Proteases/Proteasome
	Quercetin 3,4'-dimethyl ether shows anti-lipid peroxidation activity (IC 50 values of 0.3 uM), it also shows anti-inflammatory activity. Quercetin 3,4'-dimethyl ether could be useful in the development of novel anticancer agents, it has high cytotoxic aga
T73403	Aviculin	Others	Others
	Aviculin 是一种木聚糖苷，是一种有效的抗癌剂 (anticanceragent)。Aviculin 可降低 MCF-7 细胞代谢活性到 50% 以下，IC50为 75.47 μM。Aviculin 通过内在凋亡途径诱导乳腺癌细胞凋亡 (apoptosis)。Aviculin 增加了 caspase-9、caspase-7和 PARP 的表达。Aviculin 使 Bax/Bcl-2 的比值升高。

天然产物

Cat.No: TN1019

Synonym: β-Mangostin,beta-倒捻子素

Target: Apoptosis, Antibacterial, Parasite

Cat.No: T3916

Synonym: 人参皂苷F2

Target: Apoptosis, Endogenous Metabolite, Autophagy

3-Epioleanolic acid

Cat.No: TN1248

Target: AChR

Cat.No: TN2097

Synonym: 坡模酸

Target: Apoptosis, Caspase, HIV Protease, AMPK

Cat.No: T3386

Synonym: Lespedin,Kaempferol,Lespenephryl,Lespenefril,Kaempferol 3,7-dirhamnoside,山奈苷

Target: cell cycle arrest, Glucokinase, IGF-1R

Cat.No: T4746

Synonym: 7H-Imidazo(4,5-d)pyrimidine,嘌呤

Target: Others, Endogenous Metabolite

Cat.No: T7032

Target: Others, P450

Cat.No: T1040

Synonym: Cyanocobalamin,Cobalamin,维生素B12

Target: Endogenous Metabolite

Cat.No: T28122

Synonym: NSC-54384,NSC 54384,NSC54384,Benihinal

Demethoxyfumitremorgin C

Cat.No: TN6059

Erythronic acid potassium

Cat.No: T78466

Target: Endogenous Metabolite

Cat.No: T13797

Target: Caspase

α,α-Trehalose 6-phosphate potassium

Cat.No: T78471

Synonym: Tre6P potassium

Target: Endogenous Metabolite

cGAMP diammonium

Cat.No: T73717

Target: Others

Quercetin 3,4'-dimethyl ether

Cat.No: TN4877

Target: ERK, BCL, MAPK, Caspase, JNK

Cat.No: T73403

Target: Others

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-03221	Intrinsic Factor Protein, Human, Recombinant (His) IF,IFMH,gastric intrinsic factor (vitamin B synthes...	Human	HEK293 Cells
	Gastric intrinsic factor, also known as GIF, belongs to the of the cobalamin transport protein family. It is a glycoprotein produced by the parietal cells of the stomach. Gastric intrinsic factor plays a key role in the absorption of vitamin B12 on in the small intestine. Vitamin B12 bounds to haptocorrin after entry into the stomach. The resulting complex enters the duodenum, where pancreatic enzymes digest haptocorrin. In the less acidic environment of the small intestine, B12 can then bind to...
TMPH-00580	Aquaporin Z Protein, E. coli, Recombinant (His) Water channel AqpZ,bniP,Aquaporin Z,Bacterial nodulin-like <...	E. coli	E. coli
	Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity. Aquaporin Z Protein, E. coli, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 27.7 kDa and the accession number is P60844.
TMPY-05510	BDNF Protein, Mouse, Recombinant (His) brain-derived neurotrophic factor	Mouse	HEK293 Cells
	BDNF is a member of thenerve growth factorfamily. It is highly expressed in hippocampus, amygdala, cerebral cortex and cerebellum. It also can be detected in heart, lung, skeletal muscle, testis, prostate and placenta. BDNF is induced by cortical neurons, and is necessary for survival of striatal neurons in the brain. During development, BDNF promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. It participates in axonal growth,...
TMPY-01101	Coagulation factor X/F10 Protein, Human, Recombinant (His) FXA,FX,coagulation factor X,coagulation factor 10	Human	Baculovirus Insect Cells
	Coagulation factor X, also known as FX, F10, Eponym Stuart-Prower factor, and thrombokinase, is an enzyme of the coagulation cascade. It is one of the vitamin K-dependent serine proteases, and plays a crucial role in the coagulation cascade and blood clotting, as the first enzyme in the common pathway of thrombus formation. Factor X deficiency is one of the rarest of the inherited coagulation disorders. FX deficiency among the most severe of the rare coagulation defects, typically including hema...
TMPH-03057	Chorismate synthase Protein, Neurospora crassa, Recombinant (His) B7F21.10,NCU05420,aro-2,5-enolpyruvylshikimate-3-phosphate p...	Neurospora crassa	E. coli
	Bifunctional enzyme that possesses chorismate synthase and intrinsic flavin reductase activity, it uses NADPH to reduce FMN.
TMPH-03381	Synaptoporin/SYNPR Protein, Rat, Recombinant (His) Synaptoporin,Synpr	Rat	E. coli
	Intrinsic membrane protein of small synaptic vesicles. Probable vesicular channel protein. Synaptoporin/SYNPR Protein, Rat, Recombinant (His) is expressed in E. coli expression system with N-10xHis tag. The predicted molecular weight is 35.2 kDa and the accession number is P22831.
TMPH-01898	PARL Protein, Human, Recombinant (Myc) Mitochondrial intramembrane cleaving protease PARL,Presenili...	Human	E. coli
	Required for the control of apoptosis during postnatal growth. Essential for proteolytic processing of an antiapoptotic form of OPA1 which prevents the release of mitochondrial cytochrome c in response to intrinsic apoptotic signals. Required for the maturation of PINK1 into its 52kDa mature form after its cleavage by mitochondrial-processing peptidase (MPP). Promotes changes in mitochondria morphology regulated by phosphorylation of P-beta domain. PARL Protein, Human, Recombinant (Myc) is expre...
TMPK-00188	JAM-A Protein, Mouse, Recombinant (His) F11R,JCAM1,PAM-1,PAM-1KAT,JAM-1,JAM,JCAM,JAM-A,KAT,F11 recep...	Mouse	HEK293 Cells
	junctional adhesion molecule A (JAM-A), a cell adhesion molecule, is highly elevated in human GBM cancer stem cells and predicts poor patient prognosis. While JAM-A is also highly expressed in other cells in the tumor microenvironment, specifically microglia and macrophages,JAM-A functions to suppress pathogenic microglial activation in the female tumor microenvironment, highlighting an emerging role for sex differences in the GBM microenvironment and suggesting that sex differences extend beyon...
TMPY-03051	B3GNT2 Protein, Human, Recombinant (hFc) B3GNT-2,B3GNT,UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosamin...	Human	HEK293 Cells
	B3GNT2 belongs to the beta-1,3-N-acetylglucosaminyltransferase family. It is a type II transmembrane protein that prefers the substrate of lacto-N-neotetraose. Alternative splicing produced 2 isoforms of the human protein. B3GNT2 catalyzes the initiation and elongation of poly-N- acetyllactosamine chains. Enzymatic activities of some glycosyltransferases are markedly increased via complex formation with other transferases or cofactor proteins. B3GNT2 and beta3Gn-T8 can form a heterodimer in vitr...
TMPJ-01071	Apolipoprotein H/APOH Protein, Mouse, Recombinant (His) Beta-2-glycoprotein 1,Apoh,β-2-glycoprotein 1	Mouse	HEK293 Cells
	Apolipoprotein H (APOH), also known as Beta-2-glycoprotein 1, is a glycoprotein synthesized by liver cells and it is present in the blood associated with plasma lipoproteins. Its carbohydrate content is approximately 19% of the molecular weight and it is present in the blood associated with plasma lipoproteins. Mature mouse ApoH shares 76% and 42% aa sequence identity with human and rat ApoH, respectively. The activity of APOH appears to involve the binding of agglutenating, inhibits agglutinati...
TMPJ-00715	FGF-19 Protein, Human, Recombinant (His) FGF-19,Fibroblast growth factor 19,FGF19	Human	E. coli
	Fibroblast growth factor 19 (FGF19) is a secreted protein which belongs to the FGFs family. FGF19 is expressed in fetal brain, cartilage, retina, and adult gall bladder. FGFs modulate cellular activity via at least 5 distinct subfamilies of high-affinity FGF receptors (FGFRs): FGFR-1, -2, -3, and -4, all with intrinsic tyrosine kinase activity. FGFRs can be important for regulation of glucose and lipid homeostasis. FGF19 has important roles as a hormone produced in the ileum in response to bile ...
TMPJ-00301	Coagulation Factor X Protein, Human, Recombinant (hFc) Stuart-Prower factor,Stuart factor,Coagulation factor X	Human	HEK293 Cells
	F10, also known as Coagulation factor X, belongs to the peptidase S1 family that is synthesized as a 488 amino acid (aa) with a signal peptide and a pro region (residues 1‑40). Both the intrinsic and extrinsic pathways activate Factor X to Xa, which consists of light (residues 41‑179) and heavy (residues 235‑488) chains linked by a disulfide bond. Coagulation factor X is initially synthesized in the liver. The two chains are formed from a single-chain precursor by the excision of two Arg residue...
TMPJ-00192	CD32B Protein, Human, Recombinant (His) FCG2,IgG Fc Receptor II-b,CDw32,Low Affinity Immunoglobulin ...	Human	HEK293 Cells
	FcγRIIB is a low affinity receptor that recognizes the Fc portion of IgG. The human CD32 group consists of FcγRIIA, FcγRIIB, and FcγRIIC proteins that share 94-99% sequence identity in their extracellular domains but differ substantially in their transmembrane and cytoplasmic domains. FcγRII protein is expressed on cells of both myeloid and lymphoid lineages as well as on cells of non-hematopoietic origin. FcγRIIB has an intrinsic cytoplasmic immunoreceptor tyrosine-based inhibitory motif (ITIM)...
TMPY-02106	GAP43 Protein, Human, Recombinant (His) B-50,PP46,growth associated protein 43	Human	HEK293 Cells
	Neuromodulin, also known as Axonal membrane protein GAP-43, Growth-associated protein 43, Neural phosphoprotein B-5, pp46 and GAP43, is a cell membrane protein which belongs to theneuromodulin family. Neuromodulin / GAP43 contains oneIQ domain. Neuromodulin / GAP43 is associated with nerve growth. It is a major component of the motile "growth cones" that form the tips of elongating axons. Neuromodulin / GAP43 is involved in neurite outgrowth, a crucial process for the differentiation of n...
TMPY-01632	Serpin B4 Protein, Mouse, Recombinant (His) Serpinb4,1110001H02Rik,1110013A16Rik,Serpinb3c,Scca2,serine ...	Mouse	Baculovirus Insect Cells
	Serpins are the largest and most diverse family of serine protease inhibitors which are involved in a number of fundamental biological processes such as blood coagulation, complement activation, fibrinolysis, angiogenesis, inflammation and tumor suppression and are expressed in a cell-specific manner. Serpins are a group of proteins with similar structures that were first identified as a set of proteins able to inhibit proteases. The acronym serpin was originally coined because many serpins inhi...
TMPY-02220	HRAS Protein, Human, Recombinant (His) HAMSV,Harvey rat sarcoma viral oncogene homolog,C-H-RAS,C-HA...	Human	Baculovirus Insect Cells
	HRas, also known as HRAS, belongs to the small GTPase superfamily, Ras family, and is widely expressed. It functions in signal transduction pathways. HRas can bind GTP and GDP, and they have intrinsic GTPase activity. It undergoes a continuous cycle of de- and re-palmitoylation, which regulates its rapid exchange between the plasma membrane and the Golgi apparatus. Defects in HRAS are the cause of faciocutaneoskeletal syndrome (FCSS). FCSS is a rare condition characterized by prenatally increase...
TMPH-01239	XPC Protein, Human, Recombinant (His) Xeroderma pigmentosum group C-complementing protein,p125,XPC...	Human	E. coli
	Involved in global genome nucleotide excision repair (GG-NER) by acting as damage sensing and DNA-binding factor component of the XPC complex. Has only a low DNA repair activity by itself which is stimulated by RAD23B and RAD23A. Has a preference to bind DNA containing a short single-stranded segment but not to damaged oligonucleotides. This feature is proposed to be related to a dynamic sensor XPC can rapidly screen duplex DNA for non-hydrogen-bonded bases by forming a transient nucleoprotein i...

重组蛋白

Intrinsic Factor Protein, Human, Recombinant (His)

Cat.No: TMPY-03221

Species: Human

Expression System: HEK293 Cells

Aquaporin Z Protein, E. coli, Recombinant (His)

Cat.No: TMPH-00580

Species: E. coli

Expression System: E. coli

BDNF Protein, Mouse, Recombinant (His)

Cat.No: TMPY-05510

Species: Mouse

Expression System: HEK293 Cells

Coagulation factor X/F10 Protein, Human, Recombinant (His)

Cat.No: TMPY-01101

Species: Human

Expression System: Baculovirus Insect Cells

Chorismate synthase Protein, Neurospora crassa, Recombinant (His)

Cat.No: TMPH-03057

Species: Neurospora crassa

Expression System: E. coli

Synaptoporin/SYNPR Protein, Rat, Recombinant (His)

Cat.No: TMPH-03381

Species: Rat

Expression System: E. coli

PARL Protein, Human, Recombinant (Myc)

Cat.No: TMPH-01898

Species: Human

Expression System: E. coli

JAM-A Protein, Mouse, Recombinant (His)

Cat.No: TMPK-00188

Species: Mouse

Expression System: HEK293 Cells

B3GNT2 Protein, Human, Recombinant (hFc)

Cat.No: TMPY-03051

Species: Human

Expression System: HEK293 Cells

Apolipoprotein H/APOH Protein, Mouse, Recombinant (His)

Cat.No: TMPJ-01071

Species: Mouse

Expression System: HEK293 Cells

FGF-19 Protein, Human, Recombinant (His)

Cat.No: TMPJ-00715

Species: Human

Expression System: E. coli

Coagulation Factor X Protein, Human, Recombinant (hFc)

Cat.No: TMPJ-00301

Species: Human

Expression System: HEK293 Cells

CD32B Protein, Human, Recombinant (His)

Cat.No: TMPJ-00192

Species: Human

Expression System: HEK293 Cells

GAP43 Protein, Human, Recombinant (His)

Cat.No: TMPY-02106

Species: Human

Expression System: HEK293 Cells

Serpin B4 Protein, Mouse, Recombinant (His)

Cat.No: TMPY-01632

Species: Mouse

Expression System: Baculovirus Insect Cells

HRAS Protein, Human, Recombinant (His)

Cat.No: TMPY-02220

Species: Human

Expression System: Baculovirus Insect Cells

XPC Protein, Human, Recombinant (His)

Cat.No: TMPH-01239

Species: Human

Expression System: E. coli

Cat. No.	Product Name	Target	Signaling Pathways
TMID-0236	Bisoprolol-d7 hemifumarate
	Bisoprolol-d7 hemifumarate 是 Bisoprolol hemifumarate 的氘代化合物。Bisoprolol hemifumarate 的 CAS 号为 104344-23-2。Bisoprolol hemifumarate 是一种 β1 肾上腺素受体阻断剂。
TMIJ-0175	Bisoprolol-d5 Hemifumarate
	Bisoprolol-d5 Hemifumarate 是 Bisoprolol Hemifumarate 的氘代化合物。Bisoprolol Hemifumarate 的 CAS 号为 104344-23-2。Bisoprolol hemifumarate 是一种 β1 肾上腺素受体阻断剂。
TMID-0245	Pindolol-d7
	Pindolol-d7 是 Pindolol 的氘代化合物。Pindolol 的 CAS 号为 13523-86-9。Pindolol 是一种非选择性β-阻断剂，局部的β-肾上腺素能受体激动剂活性，也作为5-HT1A受体部分拮抗剂，Ki为33nM。它是非心脏选择性的，具有内在的拟交感神经作用。
TMIJ-0426	Celiprolol-d9 Hydrochloride
	Celiprolol-d9 Hydrochloride 是 Celiprolol Hydrochloride 的氘代化合物。Celiprolol Hydrochloride 的 CAS 号为 57470-78-7。Celiprolol hydrochloride 是一种选择性肾上腺素受体调节剂，是一种选择性的和具有口服活性的β1肾上腺素受体拮抗剂，具有部分β2激动剂活性，具有降压和抗心绞痛的作用。

同位素标记化合物

Bisoprolol-d7 hemifumarate

Cat.No: TMID-0236

Bisoprolol-d5 Hemifumarate

Cat.No: TMIJ-0175

Cat.No: TMID-0245

Celiprolol-d9 Hydrochloride

Cat.No: TMIJ-0426

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