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Search Results for " intracellular infection "

Targets Recommended: Antibacterial Antibiotic

6

抑制剂 & 化合物

1

天然产物

9

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T0234	Methicillin sodium salt Methicillin sodium,Meticillin sodium,甲氧西林钠	Antibacterial; Antibiotic	Microbiology/Virology
	Methicillin sodium salt 是β-内酰胺抗生素，抑制参与肽聚糖合成的青霉素结合蛋白。
T27710	K6PC-5 K6PC5,K6PC 5	S1P Receptor	GPCR/G Protein
	K6PC-5 is a ceramide derivative that acts as an activator of sphingosine kinase 1 (SPHK1), inducing a swift and temporary rise in intracellular calcium levels. With its potential applications in skin diseases associated with abnormal keratinocyte function, as well as in studies on neurodegeneration and virus infection, K6PC-5 presents a promising compound for research purposes.
T70859	ent-Abacavir	Others	Others
	ent-Abacavir is an enatiomer of Abacavir. Abacavir is a carbocyclic 2'-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection. Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA. Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuroni...
T36073	S-Acetyl-L-glutathione	Others	Others
	S-Acetyl-L-glutathione is a derivative of glutathione .1 It increases intracellular GSH levels in primary fibroblasts derived from patients with glutathione synthetase deficiency when used at a concentration of 50 μM. S-Acetyl-L-glutathione (5 mM) induces apoptosis in Daudi, Raji, and Jurkat lymphoma cells.2 It inhibits the replication of herpes simplex virus 1 (HSV-1) in human foreskin fibroblasts when used at concentrations of 5 and 10 mM.3 S-Acetyl-L-glutathione (6.25 μg/g per day) increases ...
T68457	GSK812397	Others	Others
	GSK812397 is a potent entry inhibitor of X4-tropic strains of HIV-1, as demonstrated in multiple in vitro cellular assays. GSK812397 is a noncompetitive antagonist of the CXCR4 receptor, with GSK812397 producing a concentration-dependent decrease in both an SDF-1-mediated chemotaxis and intracellular calcium release (IC50s were 0.34+/-0.01 nM and 2.41+/-0.50 nM, respectively). GSK812397 is effective against a broad range of X4- and X4R5-utilizing clinical isolates. The potency and efficacy of GS...
T82071	Influenza NP (311-325)
	Influenza NP (311-325) 是具有生物活性的肽段，对应于流感病毒核蛋白(NP)的311至325氨基酸。作为MHC II类限制性表位，它用于研究宿主在感染期间的免疫响应。该肽能在细胞内细胞因子检测中诱导强烈的γ干扰素(IFN-γ)产生，但不激活小鼠CD8 T细胞。谷氨酰胺(Q)或谷氨酸(E)位于N端时，焦谷氨酰(pGlu)肽可自发形成。Q或E向pGlu的自然转化及其疏水性γ-内酰胺环在肽的胃肠道蛋白酶稳定性中可能起作用。焦谷氨酰肽作为常见肽的一部分，在HPLC分析中评估肽的纯度。

化合物

Methicillin sodium salt

Cat.No: T0234

Synonym: Methicillin sodium,Meticillin sodium,甲氧西林钠

Target: Antibacterial, Antibiotic

Cat.No: T27710

Synonym: K6PC5,K6PC 5

Target: S1P Receptor

Cat.No: T70859

Target: Others

S-Acetyl-L-glutathione

Cat.No: T36073

Target: Others

Cat.No: T68457

Target: Others

Influenza NP (311-325)

Cat.No: T82071

Cat. No.	Product Name	Target	Signaling Pathways
T6S0525	Farrerol	ERK; p38 MAPK; Akt	Cytoskeletal Signaling; MAPK; PI3K/Akt/mTOR signaling
	Farrerol 是一种杜鹃花的生物活性成分，具有抗氧化、抗肿瘤、抗炎、神经保护和肝保护等多种功能。

天然产物

Cat.No: T6S0525

Target: ERK, p38 MAPK, Akt

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-02929	ENTPD2 Protein, Human, Recombinant (aa 29-460, His) ectonucleoside triphosphate diphosphohydrolase 2,NTPDase-2,R...	Human	Baculovirus Insect Cells
	NTPDase 2, also known as ENTPD2, belongs to the ecto-nucleoside triphosphate diphosphohydrolase family (E-NTPDase). Members of E-NTPDase family are nucleotidases able to hydrolyze 5′-nucleoside tri- and/or diphosphates; the main role of these enzymes is the termination of purinergic signaling. NTPDases are ubiquitous and were previously shown in other parasites including the trypanosomatides of genus Leishmania and in T. brucei. NTPase activity would act as a timer and is crucial to T. gondii in...
TMPH-01048	CEACAM5 Protein, Human, Recombinant (E398K, His) Carcinoembryonic antigen-related cell adhesion molecule 5,CD...	Human	HEK293 Cells
	Cell surface glycoprotein that plays a role in cell adhesion, intracellular signaling and tumor progression. Mediates homophilic and heterophilic cell adhesion with other carcinoembryonic antigen-related cell adhesion molecules, such as CEACAM6. Plays a role as an oncogene by promoting tumor progression; induces resistance to anoikis of colorectal carcinoma cells.; (Microbial infection) Receptor for E.coli Dr adhesins. Binding of E.coli Dr adhesins leads to dissociation of the homodimer. CEACAM5...
TMPK-00677	PKA/PRKACA Protein, Canine, Recombinant (His) PKA C alpha,PKACA,PPNAD4,PKA C α,PKA C-α,PKA C-alpha,PRKACA	Canine	E. coli
	The cAMP-dependent protein kinase PKA is a well-characterized member of the serine-threonine protein AGC kinase family and is the effector kinase of cAMP signaling. As such, PKA is involved in the control of a wide variety of cellular processes including metabolism, cell growth, gene expression and apoptosis. cAMP-dependent PKA signaling pathways play important roles during infection and virulence of various pathogens. Since fluxes in cAMP are involved in multiple intracellular functions, a vari...
TMPH-01247	POLR3K Protein, Human, Recombinant (His) RNA polymerase III subunit C11,POLR3K,RNA polymerase III 12....	Human	Baculovirus Insect Cells
	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase I...
TMPH-00794	Dps Protein, Helicobacter pylori, Recombinant (His & SUMO) napA,DNA protection during starvation protein,Bacterioferrit...	Helicobacter pylori	E. coli
	Protects DNA from oxidative damage by sequestering intracellular Fe(2+) ion and storing it in the form of Fe(3+) oxyhydroxide mineral. One hydrogen peroxide oxidizes two Fe(2+) ions, which prevents hydroxyl radical production by the Fenton reaction. Required for the survival in the presence of oxidative stress. Dps is also a virulence factor that activates neutrophils, mast cells and monocytes. It binds to neutrophil-glycosphingolipids and to sulfated carbohydrates on mucin. It might have a role...
TMPJ-00420	CTLA-4 Protein, Mouse, Recombinant (Flag) Cytotoxic T-lymphocyte protein 4, Cytotoxic T-lymphocyte-ass...	Mouse	HEK293 Cells
	Mouse Cytotoxic Tlymphocyte 4(CTLA-4,CD152), is a type I transmembrane T cell inhibitory molecule. Within the ECD, Mouse CTLA-4 shares 68% aa sequence identity with human. CTLA4 is similar to the T cell costimulatory protein CD28 since both of the molecules bind to CD80 and CD86 on antigen-presenting cells. CTLA4 transmits an inhibitory signal to T cells, whereas CD28 transmits a stimulatory signal. Intracellular CTLA4 is also found inregulatory T cells and may play an important role in their fu...
TMPH-02671	Gasdermin-D Protein, Mouse, Recombinant (His & Myc) Gasdermin-D,Gasdermin domain-containing protein 1,Gsdmd	Mouse	E. coli
	Precursor of a pore-forming protein that plays a key role in host defense against pathogen infection and danger signals. This form constitutes the precursor of the pore-forming protein: upon cleavage, the released N-terminal moiety (Gasdermin-D, N-terminal) binds to membranes and forms pores, triggering pyroptosis.; Promotes pyroptosis in response to microbial infection and danger signals. Produced by the cleavage of gasdermin-D by inflammatory caspases CASP1 or CASP4/CASP11 in response to canon...
TMPH-01246	POLR3A Protein, Human, Recombinant (His) RNA polymerase III subunit C160,RNA polymerase III 155 kDa s...	Human	E. coli
	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Forms the polymerase active center together with the second largest subunit. A single-stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol III. A bridging helix emanates from RPC1 and crosses the cleft ...
TMPH-02690	PLA2G10 Protein, Mouse, Recombinant (His & Myc) Pla2g10,Group X secretory phospholipase A2,Phosphatidylcholi...	Mouse	E. coli
	Secretory calcium-dependent phospholipase A2 that primarily targets extracellular phospholipids. Hydrolyzes the ester bond of the fatty acyl group attached at sn-2 position of phospholipids with preference for phosphatidylcholines and phosphatidylglycerols over phosphatidylethanolamines. Preferentially releases sn-2 omega-6 and omega-3 polyunsaturated fatty acyl (PUFA) chains over saturated fatty acyls. Contributes to phospholipid remodeling of very low-density lipoprotein (VLDL), low-density li...

重组蛋白

ENTPD2 Protein, Human, Recombinant (aa 29-460, His)

Cat.No: TMPY-02929

Species: Human

Expression System: Baculovirus Insect Cells

CEACAM5 Protein, Human, Recombinant (E398K, His)

Cat.No: TMPH-01048

Species: Human

Expression System: HEK293 Cells

PKA/PRKACA Protein, Canine, Recombinant (His)

Cat.No: TMPK-00677

Species: Canine

Expression System: E. coli

POLR3K Protein, Human, Recombinant (His)

Cat.No: TMPH-01247

Species: Human

Expression System: Baculovirus Insect Cells

Dps Protein, Helicobacter pylori, Recombinant (His & SUMO)

Cat.No: TMPH-00794

Species: Helicobacter pylori

Expression System: E. coli

CTLA-4 Protein, Mouse, Recombinant (Flag)

Cat.No: TMPJ-00420

Species: Mouse

Expression System: HEK293 Cells

Gasdermin-D Protein, Mouse, Recombinant (His & Myc)

Cat.No: TMPH-02671

Species: Mouse

Expression System: E. coli

POLR3A Protein, Human, Recombinant (His)

Cat.No: TMPH-01246

Species: Human

Expression System: E. coli

PLA2G10 Protein, Mouse, Recombinant (His & Myc)

Cat.No: TMPH-02690

Species: Mouse

Expression System: E. coli

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