78
21
6
109
3
Cat. No. | Product Name | ||
---|---|---|---|
L2000 | 抑制剂库 | 8328 compounds | |
8328 个小分子抑制剂的独特集合,主要用于细胞信号研究、新药筛选、高通量筛选和高内涵筛选; | |||
L8700 | 铁死亡化合物库 | 779 compounds | |
779 种与铁死亡通路相关的化合物,可用于高通量和高内涵筛选; | |||
L3700 | JAK-STAT 化合物库 | 252 compounds | |
252 个 JAK/STAT 靶点相关的小分子化合物的独特集合,用于高通量、高内涵筛选; | |||
L6140 | 糖类及苷类化合物库 | 595 compounds | |
595 种糖类或苷类的化合物,可用于高通量筛选和高内涵筛选; | |||
L2170 | 肿瘤免疫治疗小分子化合物库 | 449 compounds | |
449 种靶向肿瘤免疫治疗靶点的小分子,可用于高通量和高内涵筛选,是研究肿瘤免疫治疗的有力工具; | |||
L8500 | HIF-1化合物库 | 1336 compounds | |
1336 个HIF-1相关小分子的独特集合,可用于缺血性疾病、癌症等相关领域的药物开发和药理研究; |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T7388 |
GSK805
|
ROR | Metabolism |
GSK805 是能够生物利用的、具有 CNS 穿透性的 RORγt 抑制剂。 | |||
T8497 |
SX-682
|
CXCR | Autophagy; GPCR/G Protein; Immunology/Inflammation |
SX-682 是口服有效的 CXCR1和 CXCR2变构抑制剂,可以阻断肿瘤髓系抑制细胞募集并增强 T 细胞活化和抗肿瘤免疫,具有治疗去势抵抗性前列腺癌的潜力。 | |||
T4527 |
Seclidemstat
SP-2577 |
Histone Demethylase | Chromatin/Epigenetic |
Seclidemstat (SP-2577) 是非竞争性可逆KDM1A (LSD1)抑制剂,可用于尤文肉瘤的研究。它促进 SWI/SNF 复合物突变卵巢癌的抗肿瘤免疫,并抑制病毒产生、病毒 DNA 复制和晚期基因表达。 | |||
T8798 |
MSA-2
|
STING | Immunology/Inflammation |
MSA-2 是可口服的非核苷酸 STING 激动剂,以具有纳摩尔亲和力的非共价二聚体形式与 STING 结合。它在同基因小鼠肿瘤模型中显示抗肿瘤活性,与抗 PD-1 协同作用,可刺激肿瘤分泌干扰素-β,诱导肿瘤消退,具有持久的抗肿瘤免疫。 | |||
T7611 |
ODM-203
|
VEGFR; FGFR | Angiogenesis; Tyrosine Kinase/Adaptors |
ODM-203 是 FGFR 和 VEGFR 家族的抑制剂,具有显著的抗肿瘤活性,能够诱导抗肿瘤免疫。 | |||
T6593 |
ML324
|
Histone Demethylase; Others; HSV | Chromatin/Epigenetic; Microbiology/Virology; Others |
ML324 是 jumonji 组蛋白去甲基化酶的特异性抑制剂,IC50值为920 nM。 | |||
T8655 |
SR-717
|
STING | Immunology/Inflammation |
SR-717 是一种 cGAMP 的类似物,一种非核苷类 STING 激动剂,可以诱导 STING 形成“封闭”的激活构象。SR-717 具有抗肿瘤活性,可以促进免疫细胞的激活以及抗原的交叉提呈。 | |||
T15573 |
Inarigivir soproxil
SB9200 |
HCV Protease | Microbiology/Virology; Proteases/Proteasome |
Inarigivir soproxil (SB9200) 是一种先天免疫激动剂。 它还显示出针对耐药丙型肝炎病毒 (HCV) 变体的有效抗病毒活性。在基因型 1 HCV 复制子系统细胞中, HCV 1a/1b 的 EC50 为 2.2 和 1.0 μM。 | |||
T2779 |
Olaquindox
|
Others | Others |
Olaquindox 是一种具有口服活性的抗生素,是喹喔啉衍生物。它能刺激猪仔生长并降低其肠粘膜免疫力。 | |||
T5128 |
RGX-104 hydrochloride
SB742881,RGX-104 HCl,盐酸RGX-104 |
Liver X Receptor | Metabolism |
RGX-104 hydrochloride (SB742881) 是小分子LXR 激动剂,利用 ApoE 基因的转录激活,调节先天免疫。 | |||
T78210 |
STC-15
STC15 |
Others | Others |
STC-15 是一种具有口服活性和有效性的 METTL3 抑制剂,具有抗癌活性,可抑制癌症生长并诱导抗癌免疫。 | |||
T23171 |
Polyinosinic-polycytidylic acid
Poly(I:C),聚胞苷酸 |
TLR | Immunology/Inflammation |
Polyinosinic-polycytidylic acid (Poly(I:C)) 是一种双链 RNA (dsRNA),是一种 TLR3 激动剂。Polyinosinic-polycytidylic acid 可以诱导哺乳动物天然免疫。 | |||
T65796 |
β-Methyl L-aspartate hydrochloride
L-Aspartic acid β-methyl ester hydrochloride,H-Asp(OMe)-OH.HCl |
Amino Acids and Derivatives | Metabolism |
β-Methyl L-aspartate hydrochloride (L-Aspartic acid β-methyl ester hydrochloride)是一种天冬氨酸衍生物,常用于合成多种化合物且与机体免疫和代谢有关。 | |||
T19508 |
Peroxidase
|
Others | Others |
Peroxidase 来自辣根,在先天免疫、氧化活性氧、激素生物合成和多种疾病的发病机制等方面具有重要作用。 | |||
T40112 |
PROTAC PD-1/PD-L1 degrader-1
|
PD-1/PD-L1; PROTACs | Apoptosis; Cell Cycle/Checkpoint; Immunology/Inflammation; PROTAC |
PROTAC PD-1/PD-L1 degrader-1 是一种降解 PD-L1 的 PROTAC,抑制 PD-1/PD-L1 相互作用(IC50:39.2 nM)。PROTAC PD-1/PD-L1 degrader-1 可恢复 Hep3B/OS-8/hPD-L1 和 CD3 T 细胞共培养模型中被抑制的免疫力,可通过溶酶体依赖性方式降低 PD-L1 的蛋白质含量。 | |||
T22596 |
BADGE
|
PPAR | DNA Damage/DNA Repair; Metabolism |
BADGE 是一种标准化的化学过敏原。它的生理作用是通过增加组胺释放和细胞介导的免疫来实现的。 | |||
T65347 |
Methyl acetyl-L-cysteinate
(R)-Methyl 2-acetamido-3-mercaptopropanoate,N-Acetyl-L-cysteine methyl ester |
Amino Acids and Derivatives | Metabolism |
Methyl acetyl-L-cysteinate (N-Acetyl-L-cysteine methyl ester) 是一种半胱氨酸衍生物,可用于生物合成且与机体代谢和免疫有关。 | |||
T77673 |
7-FluorotryptaMine HCl
|
GPR; Arrestin | Endocrinology/Hormones; GPCR/G Protein |
7-FluorotryptaMine HCl 是一种有效的芳香单胺 GPRC5A 激动剂,可诱导 GPRC5A 介导的 β-arrestin 募集。7-FluorotryptaMine HCl 可用于研究与免疫和癌症相关的信号通路。 | |||
T35941 |
DC-Chol hydrochloride
Cholesteryl 3β-N-(dimethylaminoethyl)carbamate hydrochloride,DC-Chol (hydrochloride),DC-Cholesterol hydrochloride,Cholesteryl 3β-N-(dimethylaminoethyl)carbamate |
Beta Amyloid | Neuroscience |
DC-Chol hydrochloride(DC-Cholesterol hydrochloride) 在适当的实验条件下能抑制 Aβ40 纤维的形成且以剂量依赖性的方式显著抑制氧化hCT的淀粉样蛋白形成。DC-Chol hydrochloride可诱导改善和平衡的免疫力,能够促进乙型肝炎疫苗的研究。 | |||
T67883 |
EZH2-IN-15
SHR2554 |
Histone Methyltransferase | Chromatin/Epigenetic |
EZH2-IN-15 是zeste 2组蛋白修饰增强子(EZH2)的特异性抑制剂。EZH2在许多人类癌症中异常过表达,通过调节Treg 活性来控制适应性反应。肿瘤内EZH2的表达也被证明可以控制先天免疫 | |||
T4027 |
KIN1148
|
Influenza Virus | Microbiology/Virology |
KIN1148 是一种新型小分子佐剂,是IRF3激动剂,用于增强流感疫苗效率。 | |||
T9518 |
Inarigivir ammonium
ORI-9020 ammonium,SB-9200 ammonium,Inarigivir铵 |
HBV | Microbiology/Virology |
Inarigivir ammonium (SB-9200 ammonium) 是一种二核苷酸抗病毒化合物,可显着降低表达乙型肝炎病毒的转基因小鼠的 HBV DNA。它是一种激活细胞内先天免疫的视黄酸诱导基因-I 激动剂。 | |||
T14333 |
Asoxime dichloride
Tert-Butyl2-(2-hydroxyethyl)-1-pyrrolidinecarboxylate,Asoxime (dichloride),HI-6 |
AChR | Neuroscience |
Asoxime dichloride (Tert-Butyl2-(2-hydroxyethyl)-1-pyrrolidinecarboxylate) 是乙酰胆碱受体 (AChRs) 拮抗剂,包括烟碱受体,α7 乙酰胆碱受体。Asoxime dichloride 参与调节免疫应答。Asoxime dichloride 可作为抗原使用,改善神经系统的免疫效果。 | |||
T9125 |
Tolebrutinib
PRN2246,SAR442168 |
BTK | Angiogenesis; Tyrosine Kinase/Adaptors |
Tolebrutinib (PRN2246) 是一种选择性、有效的、具有口服活性、可透过血脑屏障的布鲁顿氏酪氨酸激酶抑制剂,能够作用于 Ramos B 细胞 (IC50:0.4 nM)、HMC 小胶质细胞 (IC50:0.7 nM)。它对中枢神经系统免疫具有功效。它可用于多发性硬化症的研究。 | |||
T77401 |
Bavituximab
Anti-PS MAb 3G4 |
Others | Others |
Bavituximab (Anti-Human Phosphatidylserine Recombinant Antibody) 是一种针对磷脂酰丝氨酸 (PS) 的单克隆抗体,具有血管靶向和免疫调节特性,能够重新激活抗肿瘤免疫来抑制肿瘤生长。Bavituximab 具有抗癌活性,常联合Paclitaxel 和 Carboplatin 来研究非小细胞肺癌。 | |||
T39982 |
DGK-IN-1
|
Others | Others |
DGK-IN-1, an extracted T cell activator, holds potential in leveraging tumor immunity. | |||
T38619 |
GSK1795091
CRX-601 |
Others | Others |
GSK1795091 (CRX-601) is a synthetic TLR4 agonist and immunologic stimulator with demonstrated antitumor activity. It serves as a vaccine adjuvant, enhancing both mucosal and systemic immunity to influenza virus vaccines. | |||
T27099 |
CU-3
CU 3,CU3 |
Others | Others |
CU-3 is a potent and selective inhibitor of diacylglycerol kinase alpha (DGKalpha). CU-3 attenuates cancer cell proliferation and simultaneously enhances immune responses including anti-cancer immunity. | |||
T22856 |
IgG light chain variable region [Homo sapiens]/IgM/kappa antibody [Mus musculus]
|
Others | Others |
IgG has four forms, provides the majority of antibody-based immunity against invading pathogens. The only antibody capable of crossing the placenta to give passive immunity to the fetus. Eliminates pathogens in the early stages of B cell-mediated (humoral | |||
TP1675 |
mTRP-2 (180-188)
mTRP-2 180-188 |
||
This peptide is a TRP-tyrosinase-related protein. Its immunization results in effective induction of antitumor immunity. | |||
T80986 |
Thymus Factor
|
||
Thymus Factor 是重要的生化物质,负责促进体液免疫功能的成熟。 | |||
T81793 |
Minretumomab
CC-49 |
||
Minretumomab (CC-49) 是针对 TAG-72(tumor-associated glycoprotein 72)的鼠源单克隆抗体,适用于癌症和免疫研究领域。 | |||
T61248 |
HDAC-IN-32
|
Others | Others |
HDAC-IN-32 is a highly effective HDAC inhibitor presenting IC50 values of 5.2, 11, and 28 nM for HDAC1, HDAC2, and HDAC6, respectively. This compound demonstrates notable anti-proliferative properties against tumor cells, as well as significant in vivo antitumor efficacy, which can elicit antitumor immunity [1]. | |||
T68805 |
PSB-1584
|
Others | Others |
PSB-1584 is a Potent Agonist of the Orphan G Protein-Coupled Receptor 84 (GPR84). GPR84, a Gi protein-coupled receptor that is activated by medium-chain (hydroxy)fatty acids, appears to play an important role in inflammation, immunity, and cancer. | |||
T41086 |
IDR-1
|
||
IDR-1 is an antimicrobial peptide with activity against both Gram-positive and Gram-negative bacteria. This compound modulates innate immunity to counter infections while avoiding evident toxicities. Additionally, IDR-1 exhibits anti-inflammatory and anti-infective properties, increases the levels of monocyte chemokines, and reduces the release of pro-inflammatory cytokines. | |||
T38794 |
LLO (91-99)
LLO (91-99),Listeriolysin O (91-99) |
||
LLO (91-99), also known as Listeriolysin O (91-99), is a class I MHC-restricted T-cell epitope derived from listeriolysin (LLO), an exotoxin. It plays a vital role as an antigen in the induction of T-cell mediated immunity in vivo. | |||
T79042 |
RIP1 kinase inhibitor 5
|
RIP kinase | Apoptosis; NF-κB |
RIP1 kinase inhibitor 5 (example 1) 为一RIP1抑制剂,作为肿瘤免疫检查点激酶应用,与 SIR1-365 (compound 13) 类似,具有抑制坏死 (necrosis) 与铁死亡活性。 | |||
T72976 |
TGFβRI-IN-6
|
Others | Others |
TGFβRI-IN-6 是一种有效的TGFβRI 抑制剂,IC50值为 0.55 nM。TGFβRI-IN-6 具有增强抗肿瘤免疫力的潜力。 | |||
T74719 |
STING-IN-6
|
Others | Others |
STING-IN-6 (compound 50) 是一种有效的STING 抑制剂,pIC50为 8.9。STING-IN-6 具有免疫研究的潜力。 | |||
T76933 | Botensilimab | ||
Botensilimab (AGEN 1181),一种针对细胞毒性T淋巴细胞抗原4 (CTLA-4) 的人源化单克隆抗体,既能激活先天性免疫也能激活适应性免疫,主要应用于癌症研究领域。 | |||
T63329 |
PD-1/PD-L1-IN-25
|
Others | Others |
PD-1/PD-L1-IN-25 是一种 PD-1/PD-L1 互作的抑制剂 (IC50: 16.17 nM),可有效激活 PBMCs 中 T 细胞的抗肿瘤免疫。PD-1/PD-L1-IN-25 能够用于研究癌症。 | |||
T61429 |
HDAC-IN-33
|
Others | Others |
HDAC-IN-33 is a highly potent HDAC inhibitor, effectively inhibiting HDAC1, HDAC2, and HDAC6 with IC50 values of 24, 46, and 47 nM, respectively. This compound demonstrates significant antiproliferation activity against tumor cells and exhibits remarkable in vivo antitumor efficacy. Additionally, HDAC-IN-33 initiates the activation of antitumor immunity [1]. | |||
T78937 |
HIF-2α-IN-9
|
HIF/HIF Prolyl-Hydroxylase | Chromatin/Epigenetic; Metabolism |
HIF-2α-IN-9(compound 35r)为HIF-2α抑制剂,能够抑制VEGF-A(IC50=305 nM),影响肿瘤细胞生长基因表达并促进巨噬细胞介导的肿瘤免疫反应。 | |||
T38794L |
LLO (91-99) acetate
LLO (91-99) acetate(137856-41-8 free base) |
Others | Others |
LLO (91-99) acetate 是一种外毒素,是李斯特菌溶血素的 I 类 MHC 限制性 T 细胞表位。 LLO (91-99) 醋酸盐对于诱导体内 T 细胞介导的免疫至关重要。 | |||
T78322 |
Lesabelimab
LDP |
||
Lesabelimab(LDP)是一种针对CD274的免疫球蛋白G1-kappa型单克隆抗体。CD274作为免疫检查点配体,能够通过与PDCD1受体的结合,抑制肿瘤的免疫反应。 | |||
T39439 |
Seclidemstat mesylate
SP-2577 mesylate |
Others | Others |
Seclidemstat mesylate (SP-2577) is a highly effective and reversible inhibitor of KDM1A (LSD1), with a Ki of 31 nM and an IC 50 of 13 nM. It demonstrates significant potential in promoting antitumor immunity in switch/sucrose nonfermentable (SWI/SNF) complex mutated ovarian cancer, while also exhibiting inhibitory effects on virus production, viral DNA replication, and late gene expression. Seclidemstat mesylate is a valuable tool for studying Ewing Sarcoma in research settings. | |||
T10252L2 |
ADU-S100 ammonium salt
ML RR-S2 CDA ammonium salt,MIW815 ammonium salt |
STING | Immunology/Inflammation |
ADU-S100 ammonium salt (ML RR-S2 CDA ammonium salt) 是干扰素基因刺激物的激活剂。 ADU-S100 ammonium salt 可导致有效的全身性肿瘤消退和免疫。 | |||
T62139 |
NDT-30805
|
Others | Others |
NDT-30805 是一种三唑吡啶酮衍生物,对 PBMC 中 IL-1β的释放具有抑制作用 (IC50: 0.013 μM)。NDT-30805 也是一种 NLRP3 inflammasome 的选择性抑制剂。NDT-30805 能够用于研究炎症和免疫。 | |||
T82043 |
Iso5-2DC18
|
Others | Others |
Iso5-2DC18是用于合成含胺脂质的化合物。该脂质适用于mRNA传递、激活STING通路及表达抗肿瘤免疫效应。 | |||
T74268 |
STING agonist-13
|
Others | Others |
STINGagonist-13 是一种STING 激动剂,通过STING 介导的免疫激活进行癌症免疫。STINGagonist-13 可刺激STING 下游信号传导并促进 I 型干扰素免疫反应。STINGagonist-13 能显著降低肿瘤体积并具有免疫记忆衍生的癌症抑制活性。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T20089 |
ATP
Atipi,ATP disodium salt hydrate,Triphosphoric acid adenosine ester,Ara-ATP,Triphosphaden,Adenosine triphosphate;Ara-ATP,Adenosine triphosphate |
Endogenous Metabolite | Metabolism |
ATP (Adenosine triphosphate) 可为细胞提供能量,参与整体能量平衡,维持细胞内稳态。ATP 可以通过与特异性嘌呤能受体的相互作用充当细胞外信号分子,以介导神经传递、炎症、细胞凋亡和骨重塑等多种过程。 | |||
T2812 |
ATP disodium salt hydrate
ATP disodium,ATP disodium salt,Adenosine disodium triphosphate,三磷酸腺苷二钠盐 |
Others; Endogenous Metabolite | Metabolism; Others |
ATP disodium salt hydrate (Adenosine disodium triphosphate) 是体内能量储存和代谢的重要物质,为代谢提供能量,同时在细胞中作为辅酶发挥作用。同时,它是也是免疫和炎症中重要的内源性信号分子。 | |||
T1352 |
ATP disodium salt
Adenosine 5'-triphosphate disodium salt,三磷酸腺苷二钠,ATP,ATP disodium,腺苷-5'-三磷酸二钠盐,Adetide,Adenosine-Triphosphate,Disodium adenosine triphosphate |
P2X Receptor; Endogenous Metabolite | Membrane transporter/Ion channel; Metabolism; Neuroscience |
ATP disodium salt (Adenosine-Triphosphate) 是体内能量储存的重要物质,为代谢提供能量,同时在细胞中作为辅酶发挥作用。Adenosine 5'-triphosphate disodium salt 也是免疫和炎症中重要的内源性信号分子。 | |||
T0927 |
Butylparaben
Butyl 4-hydroxybenzoate,Butyl parahydroxybenzoate,尼泊金丁酯,对羟基苯甲酸丁酯 |
Endogenous Metabolite; Antibacterial; Antibiotic | Metabolism; Microbiology/Virology |
Butylparaben (Butyl 4-hydroxybenzoate) 是一种标准化的化学过敏原,可增加组胺释放和细胞介导的免疫。 | |||
T5691 |
paulownin
泡桐素 |
Anti-infection | Microbiology/Virology |
Paulownin 是药用植物的成分,是泡桐木的成分。 | |||
T1297 |
Eugenol
丁香酚,4-Allylguaiacol,Allylguaiacol,4-Allyl-2-methoxyphenol,Eugenic acid |
Apoptosis; Ferroptosis; Reactive Oxygen Species; Antibacterial; Parasite | Apoptosis; Immunology/Inflammation; Metabolism; Microbiology/Virology; NF-κB |
Eugenol (Allylguaiacol) 是一种从丁香中发现的精油,抑制脂质的过氧化,具有抗菌,驱虫和抗氧化活性。 | |||
T0908 |
Chlorquinaldol
5,7-Dichloro-8-hydroxy-2-methylquinoline,Chloquinan,氯喹那多 |
Antibacterial; Antibiotic; Antifungal | Microbiology/Virology |
Chlorquinaldol (5,7-Dichloro-8-hydroxy-2-methylquinoline) 是一种抗菌剂, 有潜力研究局部皮肤病症和阴道感染。 | |||
T0834 |
Ethylparaben
Ethyl 4-hydroxybenzoate,Ethyl parahydroxybenzoate,羟苯乙酯,尼泊金乙酯 |
Antibacterial; Antifungal | Microbiology/Virology |
Ethylparaben (Ethyl parahydroxybenzoate) 是一种标准化的化学过敏原。 对羟基苯甲酸乙酯的生理作用是通过增加组胺释放和细胞介导免疫来实现的。 | |||
TJO2691 |
(-)-Fucose
L-岩藻糖,Madecassic acid,L-(-)-Fucose,L-Galactomethylose,Brahmic acid,6-Desoxygalactose |
Endogenous Metabolite; Parasite | Metabolism; Microbiology/Virology |
(-)-Fucose (6-Desoxygalactose) 是己糖中的一种,有抗感染、抗癌、增强免疫力、皮肤保湿和延缓皮肤衰老作用。 | |||
T4819 |
Pipecolic acid
DL-哌啶甲酸,(±)-Piperidine-2-carboxylic acid,呢可酸,2-Piperidinecarboxylic acid,Pipecolinic acid,Homoproline |
Others; Endogenous Metabolite; Antibacterial | Metabolism; Microbiology/Virology; Others |
Pipecolic acid (2-Piperidinecarboxylic acid) 是一种赖氨酸代谢物,是许多微生物次级代谢物的重要前体,可用作吡哆醇依赖性癫痫的诊断标记。 | |||
T2838 |
Naringenin
柚皮素,Naringetol,S-Dihydrogenistein,Pelargidanon,Salipurol,NSC 11855,NSC 34875 |
P450; Influenza Virus; Reactive Oxygen Species; Endogenous Metabolite; PPAR | DNA Damage/DNA Repair; Immunology/Inflammation; Metabolism; Microbiology/Virology; NF-κB |
Naringenin (NSC-11855) 是葡萄柚中主要的黄烷酮,可作为抗氧化剂、自由基清除剂、抗炎剂、碳水化合物代谢促进剂、免疫系统调节剂。 | |||
TQ0216 |
Ercalcitriol
1α,25-Dihydroxy Vitamin D2 |
Others | Others |
Ercalcitriol (1α,25-Dihydroxy Vitamin D2) 是维生素 D2 的活性代谢物。 Ercalcitriol 作为维生素 D 的生理活化形式,通过调节正常细胞和转化细胞中的导管素抗菌肽 (CAMP) 和防御素 β-4 (DEFB4) 基因来增强免疫力,从而对抗病原体感染。 | |||
T3S1513 |
(20R)-Protopanaxadiol
Protopanaxadiol,20R-Protopanaxadiol,(20R)-原人参二醇,(20R)-Protopanaxdiol |
Others; Antibacterial | Microbiology/Virology; Others |
(20R)-Protopanaxadiol ((20R)-Protopanaxdiol) 是黑参中20(R)-人参皂甙 Rg3的一种三萜皂苷代谢物。它抑制幽门螺杆菌的生长,有抗肿瘤活性和细胞毒性。 | |||
T10065L |
2',3'-cGAMP sodium
2'-3'-cyclic GMP-AMP sodium |
STING; cGAS | Immunology/Inflammation |
2',3'-cGAMP sodium (2'-3'-cyclic GMP-AMP sodium) 是细胞天然免疫中第二信使,在 DNA 结合条件下由 cGAMP 合成酶 (cGAS) 催化形成。2',3'-cGAMP sodium 可与 STING 结合形成二聚体,诱导 IFN-β 及其他细胞因子的产生和表达。 | |||
T64980 |
ATP disodium trihydrate
Adenosine-5'-triphosphate disodium trihydrate |
Endogenous Metabolite | Metabolism |
ATP disodium trihydrate (Adenosine-5'-triphosphate disodium trihydrate) 是体内能量储存和代谢的重要物质,是免疫和炎症中重要的内源性信号分子,可为机体代谢提供能量,同时在细胞中作为辅酶发挥作用。 | |||
T3728 |
Methyl Paraben
尼泊金甲酯,Methyl parahydroxybenzoate,Nipagin,对羟基苯甲酸甲酯,Methylparaben,Methyl 4-hydroxybenzoate,Methyl p-hydroxybenzoate |
Endogenous Metabolite; Antibacterial; Antibiotic | Metabolism; Microbiology/Virology |
Methyl Paraben (Nipagin) 是一种标准化的过敏原,是从云南铁杉中分离出来对羟基苯甲酸的甲酯。它是一种抗菌剂、防腐剂、调味剂。它的生理作用是通过增加组胺释放和细胞调控免疫实现的。 | |||
T2A2532 |
L-Histidine
Glyoxaline-5-alanine,L-(-)-Histidine,L-组氨酸,histidine,组氨酸,L-Hisidine |
Mitochondrial Metabolism; Endogenous Metabolite | Metabolism |
L-Histidine (L-(-)-Histidine) 是人类生长和组织修复所需的一种半必需氨基酸(儿童应从食物中获得)。 L-Histidine 是线粒体谷氨酰胺转运的抑制剂。 | |||
T3877 |
Esculentoside A
|
NF-κB; COX | Immunology/Inflammation; Neuroscience; NF-κB |
Esculentoside A 是一种三萜皂苷,从商陆根部分离得到。它在具有抗炎活性,对环氧合酶-2 具有选择性抑制活性。它通过抑制NF-κB 和丝裂原活化蛋白激酶信号通路抑制 LPS 诱导的急性肺损伤中的炎症反应。 | |||
T4A2399 |
Cinobufotalin
华蟾毒它灵,华蟾素 |
IL Receptor; Akt; MRP; P-gp | Cytoskeletal Signaling; Immunology/Inflammation; Membrane transporter/Ion channel; Neuroscience; PI3K/Akt/mTOR signaling |
Cinobufotalin 是一种从蟾蜍的皮肤分泌物中提取的强心类固醇或丁二烯内酯。它已被用作强心药,利尿药和止血药,也是潜在的抗肺癌药物。 | |||
TN4531 |
Methyl 3-O-feruloylquinate
|
Antifection | Microbiology/Virology |
Methyl 3-O-feruloylquinate inhibits the activity of bacteria and viruses and to regulate immunity. | |||
T40526 |
ATP dipotassium
腺苷三磷酸二钾盐,Adenosine5'-triphosphatedipotassium |
Others | Others |
ATP dipotassium (Adenosine 5'-triphosphate dipotassium) is a vital compound involved in energy storage and metabolism within living organisms. It plays a crucial role in supplying metabolic energy for driving pumps and acts as a coenzyme in cellular processes. Additionally, ATP dipotassium functions as a significant endogenous signaling molecule contributing to immunity and inflammation. |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-02904 |
TLR4 Protein, Human, Recombinant (His)
TLR-4,TOLL,toll-like receptor 4,ARMD10,TLR4,CD284 |
Human | Baculovirus Insect Cells |
TLR4, also known as TLR-4, is a member of the Toll-like receptor (TLR) family, which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. TLR4 is most abundantly expressed... | |||
TMPK-00114 |
C-Reactive Protein /CRP Protein, Human, Recombinant (His)
C-reactive protein,MGC88244,PTX1MGC149895,CRP,pentraxin 1,PT... |
Human | HEK293 Cells |
C-reactive protein (CRP) is a polypeptide molecule belonging to the family of pentraxins. CRP is synthesized primarily by the liver in response to certain pro-inflammatory cytokines. It plays an important role in innate immunity, opsonization by its properties, complement activation and immunoglobulins receptor binding. CRP is a protein of the acute systemic inflammation and is, therefore, a prime marker of inflammation.The CRP is quantified by immunonephelometry or immunoturbidimetry. C-Reactiv... | |||
TMPJ-01218 |
M-CSF/CSF1 Protein, Rat, Recombinant
CSF1,集落刺激因子,CSF-1,Macrophage colony-stimulating factor 1,M-C... |
Rat | HEK293 Cells |
Rat Macrophage colony-stimulating factor 1(MCSF,CSF1) is a single-pass type I membrane cytokine. It is a hematopoietic growth factor that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. MCSF promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. It is involved in the regu... | |||
TMPJ-00327 |
M-CSF/CSF1 Protein, Human, Recombinant (His)
Lanimostim,M-CSF,CSF-1,MCSF,CSF1,集落刺激因子,Macrophage Colony-St... |
Human | HEK293 Cells |
Macrophage Colony-Stimulating Factors (m-csf) are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and themonocytes-macrophages. CSF-1 promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. It also plays an important role in the regulation of osteoclast proliferation and differentiation, the regulatio... | |||
TMPJ-01466 |
Osteoprotegerin Protein, Human, Recombinant (aa 22-401, His)
OPG,Tumor Necrosis Factor Receptor Superfamily Member 11B,OC... |
Human | HEK293 Cells |
TNFRSF11B is a secreted protein, containing 2 death domains and 4 TNFR-Cys repeats. TNFRSF11B is a decoy receptor for the receptor activator of nuclear factor kappa B ligand (RANKL). By binding RANKL, TNFRSF11B inhibits nuclear kappa B (NF-κB) which is a central and rapid acting transcription factor for immune-related genes, and a key regulator of inflammation, innate immunity, and cell survival and differentiation. TNFRSF11B levels are influenced by voltage-dependent calcium channelsCav1.2. TNF... | |||
TMPJ-01204 |
TPSAB1 Protein, Human, Recombinant (His)
TPS1,tryptase alpha/beta 1,TPS2,tryptase α/β1,tryptase α/β 1... |
Human | HEK293 Cells |
Tryptases are serine proteases with trypsin-like specificity. Together with chymases and Cathepsin G, tryptases are important players in mast cell mediation of inflammatory and allergic responses. Tryptase alpha/beta-1(TPSAB1), also known as mast cell protease 7 (MCPT7), it exhibits anticoagulant activity due to its ability to degrade fibrinogen in the presence of a diverse array of protease inhibitors in plasma. The two Isoform 1 and isoform 2 are expressed in lung, stomach, spleen, heart and s... | |||
TMPH-02271 |
BTK Protein, Human, Recombinant (His)
BPK,AGMX1,ATK,B-cell progenitor kinase,Tyrosine-protein kina... |
Human | Baculovirus Insect Cells |
Non-receptor tyrosine kinase indispensable for B lymphocyte development, differentiation and signaling. Binding of antigen to the B-cell antigen receptor (BCR) triggers signaling that ultimately leads to B-cell activation. After BCR engagement and activation at the plasma membrane, phosphorylates PLCG2 at several sites, igniting the downstream signaling pathway through calcium mobilization, followed by activation of the protein kinase C (PKC) family members. PLCG2 phosphorylation is performed in... | |||
TMPK-00769 |
IL-2 Protein, Mouse, Recombinant (His & Avi)
白介素,白细胞介素,T-cell growth factor,TCGF,IL2,Aldesleukin |
Mouse | HEK293 Cells |
Interleukin-2 (IL-2) is an interleukin, a type of cytokine signaling molecule in the immune system. It is a 15,5 - 16 kDa protein that regulates the activities of white blood cells (leukocytes, often lymphocytes) that are responsible for immunity. IL-2 has essential roles in key functions of the immune system, tolerance and immunity, primarily via its direct effects on T cells. IL-2 Protein, Mouse, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with N-His-Avi tag. The predicted m... | |||
TMPH-01576 |
KRT16 Protein, Human, Recombinant (His & Myc)
KRT16,Keratin-16,Keratin, type I cytoskeletal 16,Cytokeratin... |
Human | E. coli |
Epidermis-specific type I keratin that plays a key role in skin. Acts as a regulator of innate immunity in response to skin barrier breach: required for some inflammatory checkpoint for the skin barrier maintenance. | |||
TMPK-00770 |
IL-2 Protein, Mouse, Recombinant (His & Avi), Biotinylated
Aldesleukin,IL2,白介素,TCGF,T-cell growth factor,白细胞介素 |
Mouse | HEK293 Cells |
Interleukin-2 (IL-2) is an interleukin, a type of cytokine signaling molecule in the immune system. It is a 15,5 - 16 kDa protein that regulates the activities of white blood cells (leukocytes, often lymphocytes) that are responsible for immunity. IL-2 has essential roles in key functions of the immune system, tolerance and immunity, primarily via its direct effects on T cells. IL-2 Protein, Mouse, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with N-His-Avi tag. T... | |||
TMPH-03635 |
GRA6 Protein, Toxoplasma gondii, Recombinant (GST)
Antigen p32,Dense granule protein 6,GRA6,Protein p33 |
TOV-Toxoplasma gondii | E. coli |
Major granular component involved in excreted-secreted antigen (ESA) immunity. May have a structural role in the membranous network of the parasitophorous vacuole (PV). GRA6 Protein, Toxoplasma gondii, Recombinant (GST) is expressed in E. coli expression system with N-GST tag. The predicted molecular weight is 38.6 kDa and the accession number is Q27003. | |||
TMPK-01303 |
TPSAB1 protein, Cynomolgus, Recombinant (His)
Tryptase alpha/beta-1,TPSB1,Tryptase I,TPS2,TPS1,Tryptase al... |
Cynomolgus | E. coli |
TPSAB1, namely tryptase alpha/beta-1, is a serine protease with trypsinlike activity. TPSAB1 is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type. It may play a role in innate immunity. Diseases associated with TPSAB1 include mastocytosis and systemic mastocytosis. | |||
TMPK-00927 |
ALK Protein, Mouse, Recombinant (hFc)
CD246,Anaplastic lymphoma kinase,ALK tyrosine kinase recepto... |
Mouse | HEK293 Cells |
Anaplastic lymphoma kinase (ALK) is mostly known for its oncogenic role in several human cancers. Recent evidences clearly indicate new roles of ALK and its genetic aberrations (e.g. gene rearrangements and mutations) in immune evasion, innate and cell-mediated immunity. New ALK-related immunotherapy approaches are demonstrating both preclinical and clinical promises. | |||
TMPK-00631 |
DR3/TNFRSF25 Protein, Mouse, Recombinant (His)
TRAMP,TNFRSF12,WSL1,LARD,DR3,WSL,DDR3,TR3,TNFRSF25,APO3,WSL-... |
Mouse | HEK293 Cells |
TNF-like ligand 1 A (TL1A) and death receptor 3 (DR3) are a ligand-receptor pair involved in the pathogenesis of inflammatory bowel disease. Group 3 innate lymphoid cells (ILC3s) regulate intestinal immunity and highly express DR3. | |||
TMPH-03633 |
GRA2 Protein, Toxoplasma gondii, Recombinant (His & Myc)
Dense granule protein 2,GRA2,GP28.5,28 kDa antigen |
Toxoplasma gondii | E. coli |
Major granular component involved in excreted-secreted antigen (ESA) immunity. Possibly acts in conjunction with GRA1. GRA2 Protein, Toxoplasma gondii, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 25.0 kDa and the accession number is P13404. | |||
TMPK-00584 |
BTN2A2 Protein, Mouse, Recombinant (His)
BTN2.2,BTF2,BT2.2,BTN2A2 |
Mouse | HEK293 Cells |
Butyrophilin (BTN) genes encode a set of related proteins. Cell surface BTN2A2 protein, such as the B7 family molecule programmed death ligand 1, was upregulated upon activation of T cells.BTN2A2 is a co-inhibitory molecule that modulates T cell-mediated immunity. | |||
TMPH-01339 |
Ficolin 3/FCN3 Protein, Human, Recombinant (His)
Collagen/fibrinogen domain-containing protein 3,Hakata antig... |
Human | E. coli |
May function in innate immunity through activation of the lectin complement pathway. Calcium-dependent and GlcNAc-binding lectin. Has affinity with GalNAc, GlcNAc, D-fucose, as mono/oligosaccharide and lipopolysaccharides from S.typhimurium and S.minnesota. Ficolin 3/FCN3 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 34.4 kDa and the accession number is O75636. | |||
TMPH-03396 |
TPSAB1 Protein, Rat, Recombinant (His & Myc & SUMO)
Mast cell protease 7,Tryptase, skin,Tpsab1,Tryptase alpha/be... |
Rat | E. coli |
Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type. May play a role in innate immunity. TPSAB1 Protein, Rat, Recombinant (His & Myc & SUMO) is expressed in E. coli expression system with N-10xHis-SUMO and C-Myc tag. The predicted molecular weight is 47.4 kDa and the accession number is P27435. | |||
TMPY-04170 |
DEFB1 Protein, Human, Recombinant (hFc)
DEFB101,defensin, β1,β Defensin 1/DEFB1,defensin, beta 1,DEF... |
Human | HEK293 Cells |
The DEFB1 gene, encoding for the constitutively expressed human beta-defensin 1 (hBD1) antimicrobial peptide is a potential candidate when studying genetic susceptibility to caries. DEFB1 genetic variations have been reported as contributing to hBD1 production impairment, leading to a greater susceptibility to be infected by oral pathogens, also leading to periodontitis. To counteract host immunity, Cryptosporidium parvum has evolved multiple strategies to suppress host antimicrobial defense. On... | |||
TMPK-00084 |
IL-17C Protein, Human, Recombinant (His & Avi)
IL-17C,Cytokine CX2,IL17C,CX2,IL-17CMGC126884 |
Human | HEK293 Cells |
Interleukin‑17C (IL‑17C) is a 15‑20 kDa glycosylated cytokine that plays an important role in mucosal immunity and chronic inflammation. The six IL‑17 cytokines (IL‑17A‑F) are encoded by separate genes but adopt a conserved cystine knot fold. IL‑17C is Cytokine that plays a crucial role in innate immunity of the epithelium, including to intestinal bacterial pathogens, in an autocrine manner. Stimulates the production of antibacterial peptides and proinflammatory molecules for host defense by sig... | |||
TMPK-01139 |
TIM-1/KIM-1/HAVCR1 Protein, Human, Recombinant (aa 21-295, His)
KIM1,TIM-1,HAVCR-1,KIM-1,TIM,TIM1,TIMD1,HAVCR,CD365,TIMD-1,H... |
Human | HEK293 Cells |
Kidney injury molecule 1 (KIM-1, also known as TIM-1) is markedly upregulated in the proximal tubule after injury and is maladaptive when chronically expressed. KIM-1-mediated epithelial cell phagocytosis of apoptotic cells protects the kidney after acute injury by downregulating innate immunity and inflammation. TIM-1/KIM-1/HAVCR1 Protein, Human, Recombinant (aa 21-295, His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 30.58 kDa and the accession numb... | |||
TMPK-00745 |
PGLYRP1 Protein, Human, Recombinant (hFc)
PGLYRP1,TAG7,PGLYRP,PGRP-SMGC126894,PGRP,Tasg7,TNFSF3L,PGRP-... |
Human | HEK293 Cells |
Innate immunity protein Tag7 (PGRP-S, PGLYRP1) can interact with the TNFα receptor, TNFR1, and block the transduction of apoptotic signals through this receptor. A complex formed between the Tag7 protein and the major heat shock protein Hsp70 can activate TNFR1 receptor and induce tumor cell death via either apoptotic or necroptotic pathway. PGLYRP1 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-hFc tag. The predicted molecular weight is 46.2 kDa and the accessio... | |||
TMPK-00438 |
SARS-COV-2 Spike S Trimer Protein (His & Avi)
COVID-19,S protein,S glycoprotein,Spike glycoprotein |
SARS-CoV-2 | HEK293 Cells |
The spike protein (S) of coronavirus (CoV) attaches the virus to its cellular receptor, angiotensin-converting enzyme 2 (ACE2). A defined receptor-binding domain (RBD) on S mediates this interaction.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity. SARS-COV-2 Spike S Trimer Protein (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 136.6 kDa and the accession number i... | |||
TMPH-02258 |
TPSB2 Protein, Human, Recombinant (E. coli, His)
Tryptase II,TPSB2,Tryptase beta-2 |
Human | E. coli |
Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type. May play a role in innate immunity. TPSB2 Protein, Human, Recombinant (E. coli, His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 31.4 kDa and the accession number is P20231. | |||
TMPH-02957 |
TPSAB1 Protein, Mouse, Recombinant (His)
Tryptase,Tryptase alpha/beta-1,Mast cell protease 7,Tpsab1 |
Mouse | E. coli |
Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type. May play a role in innate immunity. TPSAB1 Protein, Mouse, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 30.1 kDa and the accession number is Q02844. | |||
TMPH-02257 |
TPSB2 Protein, Human, Recombinant (His & Myc)
Tryptase beta-2,TPSB2,Tryptase II |
Human | P. pastoris (Yeast) |
Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type. May play a role in innate immunity. TPSB2 Protein, Human, Recombinant (His & Myc) is expressed in yeast with C-6xHis-Myc tag. The predicted molecular weight is 31.2 kDa and the accession number is P20231. | |||
TMPH-00507 |
PGRP-SC2 Protein, Drosophila melanogaster, Recombinant (His & Myc)
PGRP-SC2,Peptidoglycan-recognition protein SC2 |
Fruit fly | E. coli |
N-acetylmuramyl-L-alanine amidase involved in innate immunity by degrading bacterial peptidoglycans (PGN). Probably plays a scavenger role by digesting biologically active PGN into biologically inactive fragments. Has no direct bacteriolytic activity. PGRP-SC2 Protein, Drosophila melanogaster, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 25.2 kDa and the accession number is Q9V4X2. | |||
TMPK-00236 |
CEACAM8 Protein, Human, Recombinant (His & Avi), Biotinylated
NCA-95,CD67,CGM6,CD66b,CEACAM8 |
Human | HEK293 Cells |
Eosinophils and their products are likely important in the pathophysiology of allergic diseases, such as bronchial asthma, and in host immunity to parasitic organisms. CD66b (CEACAM8, CGM6, NCA-95) is a single chain, GPI-anchored, highly glycosylated protein belonging to the carcinoembryonic Ag supergene family. CD66b is an activation marker for human granulocytes. | |||
TMPK-00442 |
SARS-COV-2 (Omicron B.1.1.529) Spike S Trimer Protein (His & Avi), Biotinylated
S glycoprotein,COVID-19,S protein,Spike glycoprotein |
SARS-CoV-2 | HEK293 Cells |
The spike protein (S) of coronavirus (CoV) attaches the virus to its cellular receptor, angiotensin-converting enzyme 2 (ACE2). A defined receptor-binding domain (RBD) on S mediates this interaction.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity. SARS-COV-2 (Omicron B.1.1.529) Spike S Trimer Protein (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 13... | |||
TMPH-01517 |
FCGRT Protein, Human, Recombinant (GST)
IgG Fc fragment receptor transporter alpha chain,Neonatal Fc... |
Human | E. coli |
Cell surface receptor that transfers passive humoral immunity from the mother to the newborn. Binds to the Fc region of monomeric immunoglobulin gamma and mediates its selective uptake from milk. IgG in the milk is bound at the apical surface of the intestinal epithelium. The resultant FcRn-IgG complexes are transcytosed across the intestinal epithelium and IgG is released from FcRn into blood or tissue fluids. Throughout life, contributes to effective humoral immunity by recycling IgG and exten... | |||
TMPH-02740 |
IL-31R alpha Protein, Mouse, Recombinant (His)
ZcytoR17,Interleukin-31 receptor subunit alpha,Novel cytokin... |
Mouse | E. coli |
Associates with OSMR to form the interleukin-31 receptor which activates STAT3 and to a lower extent STAT1 and STAT5. May function in skin immunity. Mediates IL31-induced itch, probably in a manner dependent on cation channels TRPA1 and TRPV1. Positively regulates numbers and cycling status of immature subsets of myeloid progenitor cells in bone marrow in vivo and enhances myeloid progenitor cell survival in vitro. IL-31R alpha Protein, Mouse, Recombinant (His) is expressed in E. coli expression... | |||
TMPY-06983 |
IFN gamma Protein, Human, Recombinant (E. coli)
Interferon Gamma,IFN γ,IFN gamma,IFG,IFI,干扰素,Interferon γ |
Human | E. coli |
IFN gamma, also known as IFNG, is a secreted protein that belongs to the type II interferon family. IFN gamma is produced predominantly by natural killer and natural killer T cells as part of the innate immune response, and by CD4 and CD8 cytotoxic T lymphocyte effector T cells once antigen-specific immunity develops. IFN gamma has antiviral, immunoregulatory, and anti-tumor properties. IFNG, in addition to having antiviral activity, has important immunoregulatory functions, it is a potent activ... | |||
TMPK-00439 |
SARS-COV-2 Spike RBD Protein (His & Avi), Biotinylated
S protein RBD,S glycoprotein RBD,Spike protein RBD |
SARS-CoV-2 | HEK293 Cells |
The spike protein (S) of coronavirus (CoV) attaches the virus to its cellular receptor, angiotensin-converting enzyme 2 (ACE2). A defined receptor-binding domain (RBD) on S mediates this interaction.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity. SARS-COV-2 Spike RBD Protein (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 27 kDa and the accession nu... | |||
TMPK-00912 |
SARS Spike RBD Protein (His & Avi), Biotinylated
S glycoprotein RBD,S protein RBD,Spike protein RBD |
SARS | HEK293 Cells |
The spike protein (S) of coronavirus (CoV) attaches the virus to its cellular receptor, angiotensin-converting enzyme 2 (ACE2). A defined receptor-binding domain (RBD) on S mediates this interaction.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity. SARS Spike RBD Protein (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 27.9 kDa and the accession number... | |||
TMPK-00546 |
TIM-1/KIM-1/HAVCR1 Protein, Cynomolgus, Recombinant (His)
CD365,HAVCR1,KIM1,TIMD-1,TIM-1,KIM-1,HAVcr-1,TIM1,HAVCR,TIMD... |
Cynomolgus | HEK293 Cells |
Kidney injury molecule 1 (KIM-1, also known as TIM-1) is markedly upregulated in the proximal tubule after injury and is maladaptive when chronically expressed. KIM-1-mediated epithelial cell phagocytosis of apoptotic cells protects the kidney after acute injury by downregulating innate immunity and inflammation. TIM-1/KIM-1/HAVCR1 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 35.25 kDa and the accession number is ... | |||
TMPH-01287 |
TUFM Protein, Human, Recombinant (His)
P43,Elongation factor Tu, mitochondrial,TUFM |
Human | E. coli |
Promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. Plays also a role in the regulation of autophagy and innate immunity. Recruits ATG5-ATG12 and NLRX1 at mitochondria and serves as a checkpoint of the RIG-I/DDX58-MAVS pathway. In turn, inhibits RLR-mediated type I interferon while promoting autophagy. | |||
TMPK-00444 |
SARS-COV-2 Spike S1 NTD Protein (His & Flag)
S1 protein NTD,Spike glycoprotein Subunit1 NTD,S glycoprotei... |
SARS-CoV-2 | HEK293 Cells |
The spike protein (S) of coronavirus (CoV) attaches the virus to its cellular receptor, angiotensin-converting enzyme 2 (ACE2). A defined receptor-binding domain (RBD) on S mediates this interaction.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity. SARS-COV-2 Spike S1 NTD Protein (His & Flag) is expressed in HEK293 mammalian cells with C-His-Flag tag. The predicted molecular weight is 35 kDa and the accession number is A... | |||
TMPK-00910 |
SARS Spike S1 Protein (His & Avi)
S1 protein,S glycoprotein Subunit1,Spike protein S1,Spike,S1... |
SARS | HEK293 Cells |
The spike protein (S) of coronavirus (CoV) attaches the virus to its cellular receptor, angiotensin-converting enzyme 2 (ACE2). A defined receptor-binding domain (RBD) on S mediates this interaction.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity. SARS Spike S1 Protein (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 75.9 kDa and the accession number is P59594. | |||
TMPK-00437 |
SARS-COV-2 Spike RBD Protein (His & Avi)
S glycoprotein RBD,Spike protein RBD,S protein RBD |
SARS-CoV-2 | HEK293 Cells |
The spike protein (S) of coronavirus (CoV) attaches the virus to its cellular receptor, angiotensin-converting enzyme 2 (ACE2). A defined receptor-binding domain (RBD) on S mediates this interaction.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity. SARS-COV-2 Spike RBD Protein (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 27 kDa and the accession number is A0A6G7... | |||
TMPK-00433 |
SARS-COV-2 Spike S1 Protein (hFc & Avi), Biotinylated
S1 protein,Spike,S1 protein,Spike protein S1,S glycoprotein ... |
SARS-CoV-2 | HEK293 Cells |
The spike protein (S) of coronavirus (CoV) attaches the virus to its cellular receptor, angiotensin-converting enzyme 2 (ACE2). A defined receptor-binding domain (RBD) on S mediates this interaction.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity. SARS-COV-2 Spike S1 Protein (hFc & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-hFc-Avi tag. The predicted molecular weight is 102.6 kDa and the accession ... | |||
TMPK-00749 |
PGLYRP1 Protein, Mouse, Recombinant (hFc)
PGRPSMGC126896,TNFSF3L,PGLYRP1,TAG7,PGLYRP,PGRP,PGRP-SMGC126... |
Mouse | HEK293 Cells |
Innate immunity protein Tag7 (PGRP-S, PGLYRP1) can interact with the TNFα receptor, TNFR1, and block the transduction of apoptotic signals through this receptor. A complex formed between the Tag7 protein and the major heat shock protein Hsp70 can activate TNFR1 receptor and induce tumor cell death via either apoptotic or necroptotic pathway. PGLYRP1 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-hFc tag. The predicted molecular weight is 45.7 kDa and the accessio... | |||
TMPJ-01222 |
LRRC25 Protein, Human, Recombinant (His)
Leucine-rich repeat-containing protein 25,MAPA,Monocyte and ... |
Human | HEK293 Cells |
Leucine-rich repeat-containing protein 25(LRRC25) is a single-pass type I membrane protein and contains 3 LRR (leucine-rich) repeats. The protein expressed in plasmacytoid dendritic cells (PDC), monocyte-derived dendritic cells (MDDC), granulocytes, monocytes, B-lymphocytes, peripheral blood leukocytes, spleen, bone marrow, and, to a lesser extent, lymph nodes, fetal liver, and appendix but not in thymus. The protein may be involved in the activation of cells of innate and acquired immunity. | |||
TMPH-03550 |
EsxA Protein, S. aureus, Recombinant (His & SUMO)
esxA,Type VII secretion system extracellular protein A |
Staphylococcus aureus | E. coli |
Virulence factor that is important for the establishment of infection in the host. EsxA is required for EsxB synthesis as well as secretion. Modulates host cell apoptotic pathways and mediates together with EsxB the release of S.aureus from the host cell. By acting on apoptosis, plays a role in the modulation of dendritic cell-mediated immunity. EsxA Protein, S. aureus, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 27.... | |||
TMPJ-00748 |
Ig kappa Protein, Human, Recombinant (His)
Ig κ chain C region AG,Ig κ,Ig kappa chain C region AG,Ig ka... |
Human | HEK293 Cells |
Immunoglobulin Kappa is constant region of immunoglobulin light chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humo... | |||
TMPH-01516 |
FCGRT Protein, Human, Recombinant (His)
Neonatal Fc receptor,IgG receptor FcRn large subunit p51,FCG... |
Human | HEK293 Cells |
Cell surface receptor that transfers passive humoral immunity from the mother to the newborn. Binds to the Fc region of monomeric immunoglobulin gamma and mediates its selective uptake from milk. IgG in the milk is bound at the apical surface of the intestinal epithelium. The resultant FcRn-IgG complexes are transcytosed across the intestinal epithelium and IgG is released from FcRn into blood or tissue fluids. Throughout life, contributes to effective humoral immunity by recycling IgG and exten... | |||
TMPJ-00149 |
Complement Factor D/CFD Protein, Mouse, Recombinant (His)
C3 convertase activator,28 kDa adipocyte protein,Cfd,Adipsin... |
Mouse | HEK293 Cells |
Complement factor D, also known as adipsin, is a member of the chymotrypsin family of serine proteases, which plays an essential role in host defense as the rate-limiting enzyme in the alternative pathway of complement activation. Complement factor D activates a convertase (C3bBb) responsible for cleavage of the complement protein C3, which leads to the activation of terminal complement component C5-9 to form the membrane attack complex on microbial or cellular surfaces. It also functions in the... | |||
TMPK-01333 |
C-Reactive Protein /CRP Protein, Cynomolgus, Recombinant (His)
C-reactive protein,pentraxin 1,PTX1,PTX1MGC149895,MGC88244,C... |
Cynomolgus | HEK293 Cells |
C-reactive protein (CRP) is a polypeptide molecule belonging to the family of pentraxins. CRP is synthesized primarily by the liver in response to certain pro-inflammatory cytokines. It plays an important role in innate immunity, opsonization by its properties, complement activation and immunoglobulins receptor binding. CRP is a protein of the acute systemic inflammation and is, therefore, a prime marker of inflammation.The CRP is quantified by immunonephelometry or immunoturbidimetry. C-Reactiv... | |||
TMPK-00653 |
B7-2 Protein, Cynomolgus, Recombinant (His)
B72,MGC34413,LAB72,B7-2,FUN-1,B7-2 antigen,CD86,BU63,CD28LG2... |
Cynomolgus | HEK293 Cells |
B7-1 and B7-2 are homologous costimulatory ligands expressed on the surface of antigen presenting cells (APCs). Binding of these molecules to the T cell costimulatory receptors, CD28 and CTLA-4, is essential for the activation and regulation of T cell immunity. B7-1 and B7-2 do not form hetero-oligomers, underscoring the biological relevance of dimeric and monomeric state of B7-1 and B7-2, respectively. B7-2 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with C-His... | |||
TMPH-01560 |
IL-26 Protein, Human, Recombinant (His & Trx)
Interleukin-26,Protein AK155,IL26 |
Human | E. coli |
May play a role in local mechanisms of mucosal immunity and seems to have a proinflammatory function. May play a role in inflammatory bowel disease. Activates STAT1 and STAT3, MAPK1/3 (ERK1/2), JUN and AKT. Induces expression of SOCS3, TNF-alpha and IL-8, secretion of IL-8 and IL-10 and surface expression of ICAM1. Decreases proliferation of intestinal epithelial cells. Is inhibited by heparin. IL-26 Protein, Human, Recombinant (His & Trx) is expressed in E. coli expression system with N-6xHis-T... | |||
TMPH-01649 |
PMEL Protein, Human, Recombinant (His & SUMO)
P1,Silver locus protein homolog,Melanocytes lineage-specific... |
Human | E. coli |
Plays a central role in the biogenesis of melanosomes. Involved in the maturation of melanosomes from stage I to II. The transition from stage I melanosomes to stage II melanosomes involves an elongation of the vesicle, and the appearance within of distinct fibrillar structures. Release of the soluble form, ME20-S, could protect tumor cells from antibody mediated immunity. PMEL Protein, Human, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted... | |||
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Cat. No. | Product Name | Target | Signaling Pathways |
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TMIJ-0364 |
Eugenol-d3
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Eugenol-d3 是 Eugenol 的氘代化合物。Eugenol 的 CAS 号为 97-53-0。Eugenol是一种从丁香中发现的精油,抑制脂质的过氧化,具有抗菌,驱虫和抗氧化活性。 | |||
TMID-0251 |
Ethyl parahydroxybenzoate-d4
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Ethyl parahydroxybenzoate-d4 是 Ethyl parahydroxybenzoate 的氘代化合物。Ethyl parahydroxybenzoate 的 CAS 号为 120-47-8。Ethylparaben 是一种标准化的化学过敏原。 对羟基苯甲酸乙酯的生理作用是通过增加组胺释放和细胞介导免疫来实现的。 | |||
TMIH-0368 |
Naringenin-d4
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Naringenin-d4 是 Naringenin 的氘代化合物。Naringenin 的 CAS 号为 480-41-1。Naringenin是葡萄柚中主要的黄烷酮,可作为抗氧化剂、自由基清除剂、抗炎剂、碳水化合物代谢促进剂、免疫系统调节剂。 |