80
23
3
4
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T10016 |
Hydrocarbon chain derivative 1
6,6'-Oxybis[2,2-dimethyl-1-hexanol] |
Others | Others |
Hydrocarbon chain derivative 1 has inhibitory activities against lipid synthesis. | |||
T7202 |
ITE
|
AhR; Aryl Hydrocarbon Receptor | Immunology/Inflammation; Metabolism |
ITE 是一种有效的芳烃受体 (AhR) 内源性激动剂,Ki 值为 3 nM。它具有免疫抑制作用。 | |||
T21966 |
MeBIO
|
GSK-3; Aryl Hydrocarbon Receptor; CDK | Cell Cycle/Checkpoint; Immunology/Inflammation; PI3K/Akt/mTOR signaling; Stem Cells |
MeBIO 是一种芳烃受体激动剂,对 GSK-3 和 CDK1/CyclinB 的 IC50 分别为 44 和 55 μM。 MeBIO 不影响 GSK-3β。 | |||
T1960 |
YL-109
|
AhR; Aryl Hydrocarbon Receptor | Immunology/Inflammation; Metabolism |
YL-109是一种抗肿瘤剂,可以通过芳烃受体 AhR 信号传导诱导 Hsp70 相互作用蛋白 (CHIP) 表达,具有抑制乳腺癌细胞生长和侵袭性的能力。 | |||
T5622 |
BAY-218
AHR antagonist 1 |
AhR; Aryl Hydrocarbon Receptor | Immunology/Inflammation; Metabolism |
BAY-218 (AHR antagonist 1) 是一种芳基烃受体(AHR)拮抗剂,在人细胞系中的IC50值为 39.9 nM。 | |||
T4608 |
PDM2
|
AhR; Aryl Hydrocarbon Receptor | Immunology/Inflammation; Metabolism |
PDM2 是一种有效的选择性芳烃受体 (AhR) 拮抗剂,Ki 为 1.2±0.4 nM。 | |||
T15410 |
GNF351
|
Aryl Hydrocarbon Receptor | Immunology/Inflammation |
GNF351 是芳烃受体 (AhR) 的完全拮抗剂,具有抑制 DRE 依赖性和非依赖性活性的能力。它与结合到 AhR 的光亲和性 AhR 配体竞争,IC50为 62 nM。它在小鼠或人角质形成细胞中的毒性极小。 | |||
T10007 |
1,4-Chrysenequinone
Chrysene-1,4-dione,1,4-屈醌 |
AhR | Immunology/Inflammation; Metabolism |
1,4-Chrysenequinone (Chrysene-1,4-dione) 是多环芳香烃类,是芳烃受体 (AhR) 的激活剂 | |||
T10270 |
BAY 2416964
|
Aryl Hydrocarbon Receptor | Immunology/Inflammation |
BAY 2416964 是一种可口服的芳基烃受体拮抗剂,IC50为 341 nM,可用于研究实体瘤。 | |||
T20625 |
Prochloraz
咪鲜胺,Sporgon,Prelude |
Estrogen Receptor/ERR; AhR; Androgen Receptor; Antifungal | Endocrinology/Hormones; Immunology/Inflammation; Metabolism; Microbiology/Virology |
Prochloraz (Prelude) 是咪唑类抗真菌剂。Prochloraz 抑制羊毛甾醇的细胞色素 P450 依赖性 14α-脱甲基作用,由此抑制麦角固醇的生物合成,从而导致真菌细胞膜破裂和细胞死亡。它也是雌激素受体和 雄激素受体的拮抗剂,IC50分别为25 μM 和4 μM, 并激活芳烃受体,EC50为1μM。 | |||
T2448 |
CH-223191
CH 223191 |
AhR; Aryl Hydrocarbon Receptor | Immunology/Inflammation; Metabolism |
CH-223191 是一种特异性有效的芳烃受体 (AhR) 拮抗剂,可抑制 TCDD 介导的核转位和 AhR 的 DNA 结合,抑制 TCDD 诱导的荧光素酶活性的 IC50值为 0.03 μM。 | |||
T4607 |
CAY 10465
CAY10465,CAY10465 Exclusive |
AhR; Aryl Hydrocarbon Receptor | Immunology/Inflammation; Metabolism |
CAY 10465 是一种选择性和高亲和力的芳香烃受体(AhR)激动剂,Ki 值为 0.2 nM。 | |||
TQ0257 |
FICZ
6-Formylindolo[3,2-b]carbazole |
Aryl Hydrocarbon Receptor | Immunology/Inflammation |
FICZ (6-Formylindolo[3,2-b]carbazole) 是芳烃受体 (AhR) 的有效芳基激动剂,Kd 值为70 pM。 | |||
T1831 |
StemRegenin 1
SR1 |
AhR; Aryl Hydrocarbon Receptor | Immunology/Inflammation; Metabolism |
StemRegenin 1 (SR1) 是一种芳香烃受体拮抗剂,IC50为 127 nM。 | |||
T13276 |
VAF347
4-(3-氯苯基)-N-[4-(三氟甲基)苯基]嘧啶-2-胺 |
Aryl Hydrocarbon Receptor | Immunology/Inflammation |
VAF347 是细胞可渗透且高度亲和力的芳烃受体激动剂,可诱导AhR 信号传导,具有抗炎作用。它抑制颗粒单核细胞 (GM 期) 前体中 CD14+CD11b+单核细胞的发育。 | |||
T21704 |
5-fluoro 203
5F-203,NSC-703786 |
Others | Others |
5-fluoro 203 (NSC-703786) 是一种细胞毒性分子。它可激活芳香烃受体(AhR) 信号传导,诱导 CYP1A1 的转录,从而形成 DNA 加合物以及细胞周期阻滞。它可以提高活性氧水平,并激活 ERK、p38以及JNK。 | |||
T2623 |
PD98059
PD 98059 |
ERK; Aryl Hydrocarbon Receptor; MEK; Autophagy | Autophagy; Immunology/Inflammation; MAPK |
PD98059 是一种 MEK 抑制剂,抑制 MEK1 和 MEK2 (IC50=2/50 μM),具有非 ATP 竞争性。PD98059 也是一种 AHR 的配体而起拮抗作用。PD98059 可以抑制细胞自噬。 | |||
T2148 |
Carbidopa monohydrate
Carbidopa Hydrate,S(-)-Carbidopa,卡比多巴水合物 |
Decarboxylase; Aryl Hydrocarbon Receptor | Immunology/Inflammation; Metabolism; Others |
Carbidopa monohydrate (S(-)-Carbidopa) 是一种外周型脱羧酶抑制剂,可用于帕金森病的研究。它是一种选择性芳香烃受体 (AhR) 调节剂。它抑制胰腺癌细胞和肿瘤生长。 | |||
T0640 |
Benzyl butyl phthalate
BBP,邻苯二甲酸丁苄酯,1,2-benzenedicarboxylic acid,butyl phenylmethyl ester,Butyl benzyl phthalate |
Others; Aryl Hydrocarbon Receptor | Immunology/Inflammation; Others |
Benzyl butyl phthalate (1,2-benzenedicarboxylic acid) 是邻苯二甲酸酯的一员,可激活乳腺癌细胞中的芳香烃受体,刺激 SPHK1/S1P/S1PR3 信号传导,促进转移性乳腺癌干细胞的形成。它通过上调 Zeb1 的表达,可引起血管瘤细胞的迁移和侵袭。 | |||
T2707 |
Pifithrin-α hydrobromide
Pifithrin hydrobromide,Pifithrin-α (PFTα) HBr,Pifithrin-α,PFTα,PFTα hydrobromide |
Ferroptosis; Aryl Hydrocarbon Receptor; p53 | Apoptosis; Immunology/Inflammation |
Pifithrin-α hydrobromide (Pifithrin-α hydrobromide) 是一种 p53 抑制剂,可抑制 p53 反应基因的 p53 依赖性反式激活。它也是芳烃受体的激动剂。 | |||
T8980 |
SGA360
|
Aryl Hydrocarbon Receptor | Immunology/Inflammation |
SGA360 是选择性芳烃 (Ah) 受体调节剂。 它具有抗炎特性。 | |||
T10269 |
AHR antagonist 2
|
Aryl Hydrocarbon Receptor | Immunology/Inflammation |
AHR antagonist 2 是芳基烃受体的拮抗剂。 人 AHR 和小鼠 AHR 的 IC50 分别为 0.885 和 2.03 nM。 | |||
T5541 |
PDM11
1-[2-(4-Chloro-phenyl)-vinyl]-3,5-diMeth,PDM 11 |
AhR | Immunology/Inflammation; Metabolism |
PDM11 (1-[2-(4-Chloro-phenyl)-vinyl]-3,5-diMeth) 是抗氧化剂白藜芦醇的衍生物。它在白藜芦醇活性测定中不活跃。它对辐射分解产生的羟基自由基引发的亚油酸胶束氧化没有明显的保护作用。 | |||
T0352 |
Dibenzothiophene
二苯并噻吩,Imino semicarbazide,Diphenylene sulfide |
Others | Others |
Dibenzothiophene (Imino semicarbazide) 是有机合成过程的中间体,是由两个苯环稠合到一个中心的噻吩环。 | |||
T0954 |
Halothane
Narcotane,氟烷,Anestan |
Potassium Channel; Chloride channel; GABA Receptor; NMDAR | Membrane transporter/Ion channel; Neuroscience |
Halothane (Anestan) 可以减弱内皮依赖性舒张作用。 | |||
T19057 |
Solvent Blue 35
Sudan Blue II,溶剂蓝35,溶剂蓝 35,Oil Blue 35 |
Others | Others |
Solvent Blue 35 (Sudan Blue II) 是一种可用于着色醇类和烃基溶剂的染料。它能够作用于染色动物组织中的甘油三酯。 | |||
T10325 |
ANI-7
|
Chk | Cell Cycle/Checkpoint |
ANI-7是芳香烃受体(AhR)途径的激活剂。ANI-7抑制多种癌症细胞的生长,并有效且选择性地抑制MCF-7乳腺癌症细胞的生长(GI50:0.56μM)。 | |||
T34298 |
Retene
NSC 26317,NSC-26317,NSC26317 |
Others | Others |
Retene (NSC-26317) 广泛存在于近代和古代沉积物中,可从冷杉林土壤、腐殖质煤、陆相石油烃源岩和深海沉积物中提取得到化合物。Retene 是松木酸在成岩作用过程中脱氢产生的。 | |||
T3637 |
Pifithrin-β hydrobromide
Cyclic PFT-α,PFT-β,Cyclic Pifithrin-α hydrobromide,Pifithrin-β,PFT β (hydrobromide) |
Ferroptosis; p53 | Apoptosis |
Pifithrin-β hydrobromide (Cyclic PFT-α) 是一种 p53 的抑制剂,可逆地阻断 p53 依赖性转录激活和细胞凋亡。IC50值为23 μM。 | |||
T10526 |
β-NF-JQ1
|
Others; PROTACs | Others; PROTAC |
β-NF-JQ1是一种PROTAC,可将芳烃受体E3 (AhR E3) 连接酶招募到目标蛋白上。β-NF-JQ1使用β-NF 作为AhR 配体靶向含溴odomain(BRD)的蛋白,诱导AhR 和BRD 蛋白相互作用。β-NF-JQ1显示出与蛋白敲除活性相关的强大的抗癌活性 。 | |||
T24960 |
10-Cl-BBQ
10ClBBQ |
Others | Others |
10-Cl-BBQ is a ligand of aryl hydrocarbon receptor (AhR). | |||
T25235 |
CHD-5
CHD5 |
Others | Others |
CHD-5 is a selective antagonist of the aryl hydrocarbon receptor (AhR). | |||
T20307 |
Benzyl 2-naphthyl ether
AI3 00945,AI300945,AI3-00945 |
Others | Others |
Benzyl 2-naphthyl ether causes the activation of the aryl hydrocarbon receptor. | |||
T23994 |
Dibenzo(a,i)pyrene
DB(a,i)p,Benzo(rst)pentaphene |
Others | Others |
Dibenzo(a, i)pyrene is a polycyclic aromatic hydrocarbon with potent carcinogenic activity. | |||
T23686 |
AHR-activator-1023
Branching Morphogenesis Modulator 1023,Cpd 1023,Compound 1023,BMM 1023 |
Others | Others |
AHR-activator-1023 is the aryl hydrocarbon receptor activator. It is also a specific FGF2-induced branching morphogenesis modulator. | |||
T16082 |
Mivotilate
YH439 |
Others | Others |
Mivotilate, a potent, non-toxic aryl hydrocarbon receptor (AhR) activator, functions as a hepatoprotective agent. | |||
T10258 |
AFP464 free base
NSC710464 free base |
HIF | Angiogenesis; Chromatin/Epigenetic |
AFP464 (NSC710464) free base is an active HIF-1α inhibitor (IC50: 0.25 μM) and a potent aryl hydrocarbon receptor (AhR) activator. | |||
T14059 |
6-Maleimidocaproic acid-PFP ester
|
Others | Others |
6-Maleimidocaproic acid-PFP ester is a hydrocarbon-based PROTAC linker, suitable for the synthesis of PROTACs[1]. | |||
T10271 |
AHR antagonist 4
|
Others | Others |
AHR antagonist 4 is a potent aryl hydrocarbon receptor (AHR) antagonist(example 293; IC50: 82.2 nM).It has anti-cancer effects. | |||
T10272 |
AHR antagonist 5
|
Others | Others |
AHR antagonist 5 is a potent and orally active aryl hydrocarbon receptor (AHR) antagonist(example 39; IC50 < 0.5 μΜ). It significantly inhibits tumor growth combined with checkpoint inhibitor anti-PD-1. | |||
T22528 |
6,2',4'-Trimethoxyflavone
|
Others | Others |
The compound is an Aryl hydrocarbon receptor antagonist (EC50 = 0.9 μM). It also has no short term agonist activity and no species or promoter dependence. | |||
T84400 |
5-methyl Chrysene
NSC 407620 |
Others | Others |
5-Methylchrysene, a carcinogenic polycyclic aromatic hydrocarbon with four fused rings, functions as an aryl hydrocarbon receptor agonist. It is generated through the incomplete combustion of organic matter and primarily detected in gasoline exhaust and tobacco smoke. Additionally, 5-Methylchrysene can be converted into mutagenic metabolites by cytochrome P450 enzymes 1A1 and 1B1. | |||
T19927 |
Asphalt
Bitumen,Asphalt fumes,Dacholeum |
Others | Others |
Asphalt is a dark liquid. It is also a mixture of heavy hydrocarbon residues including saturated and unsaturated hydrocarbons and aromatic hydrocarbons. | |||
T70240 |
Caparratriene
|
Others | Others |
Caparratriene is a new sesquiterpene hydrocarbon isolated from Ocotea caparrapi with potential for significant growth inhibitory activityagainst CEM leukemia cells | |||
T22725 |
DiMNF
|
Others | Others |
DiMNF is a selective aryl hydrocarbon receptor (AHR) modulator. It also suppresses the expression of CD55 and CD46 induced by IL-1β in an inflammatory tumor cell microenvironment. | |||
T23400 |
StemRegenin 1 (hydrochloride)
StemRegenin 1 (hydrochloride) (1227633-49-9 free base) |
Others | Others |
StemRegenin 1 is an aryl hydrocarbon receptor signaling antagonist (IC50: 127 nM in CD34+ cells). | |||
T84509 |
Sphingosine (d15:1)
D-erythro-Sphingosine C-15 |
Others | Others |
Sphingosine (d18:1), an amino alcohol, is chiefly recognized for its 18-carbon unsaturated hydrocarbon chain. Nevertheless, in mammalian tissues, both sphingosine and its variant, dihydrosphingosine, feature hydrocarbon chains ranging from 12 to 26 carbons. Sphingosine (d15:1) represents a naturally rare variant, serving as an internal standard for chromatographic or spectrometric analyses of sphingoid compounds. | |||
T32115 |
Hydrogenated didecene
1-Decene,dimers,Dec-1-ene,hydrogenated,dimer |
Others | Others |
Hydrogenated didecene as skin-softening agent derived from didecene, which is a hydrocarbon. Hydrocarbons are organic compounds that contain only carbon and hydrogen. Examples of common hydrocarbons include mineral oil, petroleum, and paraffin wax. | |||
T10273 |
AhR modulator-1
|
Others | Others |
AhR modulator-1 is a selective and orally active aryl hydrocarbon receptor (AhR) modulator. It inhibits metastasis, in part, by inhibiting prostatic VEGF production prior to tumor formation. It also possesses anti-estrogenic properties in rat uterus. | |||
TP2117 |
SAHM1
|
||
Notch pathway inhibitor - stabilized hydrocarbon-stapled alpha helical peptide. Targets the protein-protein interface and prevents Notch complex assembly. |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T7914 |
Acenaphthylene
|
Others | Others |
Acenaphthylene 是多环芳烃。其中多环芳烃是自然衍生于煤和焦油沉积物中,并由有机质的不完全燃烧得到。 | |||
TN1451 |
Brevifolincarboxylic acid
|
AhR; Aryl Hydrocarbon Receptor; Glucosidase | Immunology/Inflammation; Metabolism |
Brevifolincarboxylic acid 是从头状蓼中分离得到的一种天然产物,抑制芳烃受体(AhR)。它是一种 α-葡萄糖苷酶抑制剂,IC50 为 323.46 μM。 | |||
T6795 |
Carbidopa
卡比多巴,(S)-(-)-Carbidopa,Lodosyn |
Decarboxylase; Aryl Hydrocarbon Receptor | Immunology/Inflammation; Metabolism; Others |
Carbidopa (Lodosyn) 是一种选择性芳香烃受体(AhR)调节剂,是外周型脱羧酶抑制剂,抑制胰腺癌细胞和肿瘤生长,可用于帕金森病的研究。 | |||
T4928 |
L-Kynurenine
L-犬尿氨酸,(S)-Kynurenine |
AhR; Aryl Hydrocarbon Receptor; Endogenous Metabolite | Immunology/Inflammation; Metabolism |
L-Kynurenine ((S)-Kynurenine) 是L-色氨酸的代谢物,是芳香烃受体激动剂,可抑制同种异体 T 细胞增殖并增加恶性 U87 神经胶质瘤细胞侵入胶原基质。 | |||
TN6925 |
Pristane
姥鲛烷,2,6,10,14-tetramethylpentadecane |
Others | Others |
Pristane (2,6,10,14-tetramethylpentadecane) 是一种天然存在的烃油,是矿物油中最活跃的成分,较少存在于许多植物、各种海洋生物中。它是一种非抗原性佐剂,可诱导大鼠中 MHC II 类限制性关节炎 T 细胞。 | |||
T0878 |
Diosmin
Venosmine,Diosmil,Barosmin,地奥司明,地奥司明(7-芸香糖甙) |
Aryl Hydrocarbon Receptor; Norepinephrine | Immunology/Inflammation; Neuroscience |
Diosmin (Venosmine) 是在各种柑橘类水果中发现的类黄酮,也是芳烃受体激动剂,有增强血管壁的作用。 | |||
T4644 |
Tapinarof
GSK2894512,Benvitimod,苯烯莫德,WBI 1001 |
AhR; Aryl Hydrocarbon Receptor | Immunology/Inflammation; Metabolism |
Tapinarof (Benvitimod) 是一种从发光杆菌中提取的天然产物,可消除炎症。它是芳烃受体 (AhR) 激动剂,EC50为 13 nM。 | |||
TN2883 |
3',4'-Dimethoxyflavone
|
Others; PARP | Chromatin/Epigenetic; DNA Damage/DNA Repair; Others |
3',4'-Dimethoxyflavone 是类黄酮化合物的参考标准,类黄酮化合物具有多种药用活性。 | |||
T4939 |
Indole-3-pyruvic acid
3-(3-吲哚基)-2-氧代丙酸,3-(3-Indolyl)-2-oxopropanoic acid |
Others | Others |
Indole-3-pyruvic acid (3-(3-Indolyl)-2-oxopropanoic acid) 是一种参与Indole-3-acetic acid 生物合成的化合物,Indole-3-acetic acid 是一种植物激素,在调节生长和对环境变化的反应中起重要作用。 | |||
T5281 |
Skatole
粪臭素,Scatole,3-Methylindole,3-Methylindole,3-甲基吲哚,3-Methyl-1H-indole,beta-Methylindole |
AhR; p38 MAPK; Aryl Hydrocarbon Receptor; Endogenous Metabolite; Antibacterial; Autophagy; Antifungal | Autophagy; Immunology/Inflammation; MAPK; Metabolism; Microbiology/Virology |
Skatole (3-Methyl-1H-indole) 是由肠道菌群产生的,通过激活芳基烃受体和 p38调节肠上皮细胞功能。 | |||
T2947 |
Indole-3-carbinol
吲哚-3-甲醇,I3C,3-Indolemethanol,3-吲哚甲醇,Indole-3-Methanol |
E1/E2/E3 Enzyme; NF-κB; Aryl Hydrocarbon Receptor; Endogenous Metabolite; p53 | Apoptosis; Immunology/Inflammation; Metabolism; NF-κB; Ubiquitination |
Indole-3-carbinol (I3C) 是樟子松中的一种天然产物,是可口服的硫代葡萄糖苷葡糖苷酶裂解产物。它是芳烃受体 (AhR) 的激动剂,可抑制 NF-κB 和 IκBα 激酶活化。 | |||
T14961 |
Chrysene
䓛,屈 |
Others | Others |
Chrysene 是高分子量 (HMW) 多环芳烃,有极强的顽固性和致癌性。 | |||
T5226 |
2-(2-Methylbenzamido)acetic acid
2-Methylhippuric acid,2-甲基马尿酸,O-Toluric acid,N-(O-Toluoyl)glycine |
Others; Endogenous Metabolite | Metabolism; Others |
2-(2-Methylbenzamido)acetic acid (O-Toluric acid) 是一种能够在尿液中检测到的代谢物。 | |||
TN6835 |
(E)-β-Farnesene
(6E)-7,11-dimethyl-3-methylidenedodeca-1,6,10-triene,trans-β-Farnesene |
Antifungal | Microbiology/Virology |
(E)-β-Farnesene (trans-β-Farnesene) 是一种存在于 Phlomis aurea Decne中的倍半萜烃,是许多蚜虫报警信息素的主要成分,可中断蚜虫摄食。(E)-β-Farnesene 通过破坏昆虫激素平衡来损害 Chilo suppressalis 幼虫的发育和存活。 | |||
T3776 |
Rhapontigenin
丹叶大黄素,Protigenin |
P450; Antibacterial; Antifungal | Metabolism; Microbiology/Virology |
Rhapontigenin (Protigenin) 是一种基于机制的选择性细胞色素 P450 1A1 (IC50: 400 nM) 灭活剂。它是一种芳烃羟化酶,可激活作为致癌物质的多环芳烃。它是白藜芦醇的天然类似物,具有抗癌,抗氧化剂,抗真菌和抗菌活性。 | |||
TN6694 |
5,6-Benzoflavone
β-Naphthoflavone,beta-NF |
Antioxidant | oxidation-reduction |
5,6-Benzoflavone (β-Naphthoflavone) 是芳烃受体的外源配体,可破坏人肝癌 HepG2 细胞中的锌稳态。5,6-Benzoflavone (β-Naphthoflavone) 具有抗炎和抗氧化活性,抑制通过 AKT/Nrf-2/HO-1-NF-kappaB 信号转导轴,抑制 LPS 诱导的炎症,抑制TNF-α诱导的ICAM-1和VCAM-1表达,可用于研究神经退行性疾病。 | |||
T2864 |
Lycopene
番茄红素,ψ,ψ-Carotene |
Reactive Oxygen Species; ROS | Immunology/Inflammation; Metabolism; NF-κB |
Lycopene (ψ,ψ-Carotene) 是一种番茄及其产品和其他红色水果和蔬菜中天然存在的类胡萝卜素,具有抗氧化活性。 | |||
T4938 |
Potassium 1H-indol-3-yl sulfate
硫酸吲哚钾盐,Indoxyl sulfate potassium salt,Potassium 3-indoxyl sulfate |
AhR; Endogenous Metabolite | Immunology/Inflammation; Metabolism |
Potassium 1H-indol-3-yl sulfate (Potassium 3-indoxyl sulfate) 是人芳烃受体(AhR)的激动剂。芳烃受体(AhR)最近被发现是免疫炎症条件的病理生理调节剂,Potassium 1H-indol-3-yl sulfate 已被证明是AhR的配体。Potassium 1H-indol-3-yl sulfate 也是膳食蛋白质中色氨酸的代谢物。色氨酸被肠道细菌代谢为吲哚,吲哚被吸收到血液中,然后在肝脏中进一步代谢为硫酸吲哚,通常通过尿液排出体外。在肾功能受损的慢性肾病患者中,Potassium 1H-indol-3-yl sulfate 可作为尿毒症毒素在血清中积累,诱导氧化应激并加速疾病进展。250 μM Potassium 1H-indol-3-yl sulfate 可诱导NF-Κb活化,促进大鼠近端小管细胞TGF-β1和Smad3的表达,与促纤维化活性相关。 | |||
T82897 |
Benzo[e]pyrene
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Benzo[e]pyrene为化石燃料中检出的多环芳烃(PAHs)类剧毒成员。 | |||
T78469 |
α-Copaene
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Others | Others |
α-Copaene,一种倍半萜烃,具有水果挥发物性质,可作为橄榄实蝇(Bactrocera oleae)的产卵促进剂。 | |||
TN6366 |
Lupinalbin A
鲁冰花 |
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Lupinalbin A as the most potent estrogen receptor α- and aryl hydrocarbon receptor agonist in Eriosema laurentii de Wild. (Leguminosae). It exerts anti-inflammatory effects via the inhibition of pro-inflammatory cytokines and blocking of IFN-β/STAT1 pathw | |||
T75433 |
Norisoboldine hydrochloride
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Others | Others |
Norisoboldine hydrochloride是一种口服活性天然芳基烃受体(AhR)激动剂,作为林参中的主要异喹啉类生物碱,适用于类风湿性关节炎和溃疡性结肠炎的研究。 | |||
T73402 |
Flavipin
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Others | Others |
Flavipin 是一种芳香烃受体(Ahr)激动剂,可诱导小鼠 CD4+T 细胞和 CD11b+巨噬细胞表达 Ahr 下游基因。Flavipin 抑制 Arid5a 在 Il23a3'UTR 上的稳定功能,这是一种新发现的靶 mRNA。Flavipin 具有清除 DPPH 自由基的能力,IC50值为7.2 μM,对α-葡萄糖苷酶具有较强的抑制作用,IC50值为 33.8 μM。 |
Cat. No. | Product Name | Species | Expression System |
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TMPH-00958 |
AHR Protein, Human, Recombinant (His)
Aryl hydrocarbon receptor,Class E basic helix-loop-... |
Human | E. coli |
AHR Protein, Human, Recombinant (His) is expressed in E. coli. | |||
TMPH-00957 |
ARNT Protein, Human, Recombinant (His)
Hypoxia-inducible factor 1-beta,Class E basic helix-loop-hel... |
Human | P. pastoris (Yeast) |
ARNT Protein, Human, Recombinant (His) is expressed in Yeast. | |||
TMPY-01709 |
HIF-1 alpha Protein, Human, Recombinant (His)
bHLHe78,HIF-1 α,hypoxia inducible factor 1, alpha subunit (b... |
Human | E. coli |
HIF-1 alpha, also known as HIF1A, contains 1 basic helix-loop-helix (bHLH) domain, 1 PAC (PAS-associated C-terminal) domain, and 2 PAS (PER-ARNT-SIM) domains. It is one of the two subunits of Hypoxia-inducible factor-1 (HIF1). HIF1 is a transcription factor found in mammalian cells cultured under reduced oxygen tension that plays an essential role in cellular and systemic homeostatic responses to hypoxia. HIF1 is a heterodimer composed of an alpha subunit and a beta subunit. The beta subunit has... |
Cat. No. | Product Name | Target | Signaling Pathways |
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TMIJ-0387 |
Toluene-d8
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Toluene-d8 是 Toluene 的氘代化合物。Toluene 的 CAS 号为 108-88-3。 | |||
TMIJ-0389 |
Chrysene-d12
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Chrysene-d12 是 Chrysene 的氘代化合物。Chrysene 的 CAS 号为 218-01-9。Chrysene 是高分子量 (HMW) 多环芳烃,有极强的顽固性和致癌性。 | |||
TMIJ-0529 |
Acenaphthylene-d8
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Acenaphthylene-d8 是 Acenaphthylene 的氘代化合物。Acenaphthylene 的 CAS 号为 208-96-8。Acenaphthylene 是多环芳烃。其中多环芳烃是自然衍生于煤和焦油沉积物中,并由有机质的不完全燃烧得到。 | |||
T70313 |
Indoxyl Sulfate-d5 potassium salt
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Indoxyl sulfate-d5 is intended for use as an internal standard for the quantification of indoxyl sulfate by GC- or LC-MS. Indoxyl sulfate is a uremic toxin and a metabolite of tryptophan. It is formed via sulfation of indole, an intermediate generated from tryptophan by intestinal bacteria, by the sulfotransferase (SULT) isoform 1A1 variant 2 (SULT1A1*2) in the liver. Indoxyl sulfate activates the aryl hydrocarbon receptor (AhR) in HepG2 40/6 hepatoma cells (EC50 = 12.1 nM in a reporter assay). ... |