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Search Results for " hearing "

Targets Recommended: Adenosine Receptor

9

抑制剂 & 化合物

11

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T7683	Adenosine amine congener ADAC	Adenosine Receptor	GPCR/G Protein; Neuroscience
	Adenosine amine congener (ADAC) 是一种选择性的 A1 腺苷受体激动剂，具有神经保护作用，可以改善噪音和顺铂引起的耳蜗损伤。
T1812	KX1-004 KX1 004,KX1004	Src	Angiogenesis; Tyrosine Kinase/Adaptors
	KX1-004 是非 ATP 竞争性 Src-PTK 抑制剂，IC50=40 μM。它能够保护耳蜗，使其免受有害噪音的影响，并防止噪音引起的听力损失 (NIHL)。
T33815	ORC-13661 HCl ORC 13661,BPN13661,ORC13661,ORC-13661,BPN 13661,BPN-13661	Others	Others
	Orc-13661 (BNP-13661) is a potent and well-tolerated oral active protective agent for the prevention of aminogrogycoside-induced hearing loss.
T61594	BF844	Others	Others
	BF844 is a chemical compound that demonstrates the ability to mitigate hearing loss in individuals with Usher Syndrome Type III (USH3) caused by the CLRN1 mutation (specifically N48K). One of its mechanisms of action is the transportation of CLRN1 N48K to the plasma membrane. In vivo studies have shown that BF844 significantly preserves hearing [1].
T78217	(R)-Azasetron besylate SENS-401	Phosphatase	Metabolism
	(R)-Azasetron besylate (SENS-401)是一种口服活性的钙调神经磷酸酶抑制剂，能够减轻Cisplatin引发的听力损失和耳蜗损害。
T72224	NK1 receptor antagonist 2	Others	Others
	NK1receptor antagonist 2 是一种 NK1受体拮抗剂。NK1receptor antagonist 2 可用于耳鸣和听力损失的研究。
T65440	Sodium Thiosulfate Pentahydrate	Others	Others
	Sodium thiosulfate (Pentahydrate) is an antioxidant and antifungal. Sodium thiosulfate protects against cisplatin-induced hearing loss in children and is not associated with serious adverse events attributed to its use[3]. The addition of sodium thiosulfate, administered 6 hours after cisplatin chemotherapy, resulted in a lower incidence of cisplatin-induced hearing loss among children with standard-risk hepatoblastoma, without jeopardizing overall or event-free survival[4]. Calciphylaxis is a p...
T81664	NMB-1
	NMB-1，一种锥肽类似物，选择性抑制感觉神经元的持续机械激活电流(IC50: 1 μM)，有效抑制机械性疼痛，并可用于研究听力和压力诱发疼痛。
T80852	VRT-534	Others	Others
	VRT-534 针对连接蛋白 26 (Cx26)。在与重组WT Cx26及其突变体Cx26 K188N的结合中，VRT-534 显示出剂量依赖性，其EC50值分别为19 μM与5 μM。该化合物可应用于听力障碍的相关研究。

化合物

Adenosine amine congener

Cat.No: T7683

Synonym: ADAC

Target: Adenosine Receptor

Cat.No: T1812

Synonym: KX1 004,KX1004

Target: Src

Cat.No: T33815

Synonym: ORC 13661,BPN13661,ORC13661,ORC-13661,BPN 13661,BPN-13661

Target: Others

Cat.No: T61594

Target: Others

(R)-Azasetron besylate

Cat.No: T78217

Synonym: SENS-401

Target: Phosphatase

NK1 receptor antagonist 2

Cat.No: T72224

Target: Others

Sodium Thiosulfate Pentahydrate

Cat.No: T65440

Target: Others

Cat.No: T81664

Cat.No: T80852

Target: Others

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-00368	ALR Protein, Human, Recombinant (His) HPO,ERV1,HERV1,ALR,HSS,HPO2,growth factor, augmenter of live...	Human	HEK293 Cells
	Alterations in GFER gene have been associated with progressive mitochondrial myopathy, congenital cataracts, hearing loss, developmental delay, lactic acidosis and respiratory chain deficiency in 3 siblings born to consanguineous Moroccan parents by homozygosity mapping and candidate gene approach. Using homozygosity mapping, we discovered that a mutation in the GFER gene causes an infantile mitochondrial disorder.
TMPY-02289	CIB2 Protein, Human, Recombinant (His) DFNB48,calcium and integrin binding family member 2,USH1J,KI...	Human	E. coli
	Calcium and integrin-binding protein 2 (CIB2) belongs to a protein family with four known members, CIB1 through CIB4, which are characterized by multiple calcium-binding EF-hand domains. Sensorineural hearing loss is genetically heterogeneous. The mutations in CIB2, which encodes a calcium- and integrin-binding protein, are associated with nonsyndromic deafness (DFNB48) and Usher syndrome type 1J (USH1J). Furthermore, in zebrafish and Drosophila melanogaster, CIB2 is essential for the function a...
TMPJ-00243	Serpin B6 Protein, Human, Recombinant (E. coli, His) CAP,PI6,SERPINB6,Placental Thrombin Inhibitor,Cytoplasmic An...	Human	E. coli
	Serpin B6 belongs to the serpin family. Serpin B6 localizes to the cytoplasm. Serpin B6 is expressed in many tissues, abundantly by mast cells in different tissues and mastocytoma lesions. Serpin B6 may be involved in the regulation of serine proteinases present in the brain or extravasated from the blood. In addition, Serpin B6 may play an important role in the inner ear in the protection against leakage of lysosomal content during stress and loss of this protection results in cell death and se...
TMPY-01380	Cyclophilin B Protein, Human, Recombinant (His) CYPB,peptidylprolyl isomerase B (cyclophilin B),HEL-S-39,SCY...	Human	HEK293 Cells
	PPIB is identified as a candidate gene for OI-IX. Osteogenesis imperfecta (OI) is an inherited disorder of connective tissue typically caused by defects in either COL1A1 or COL1A2. A number of other genes causative of this disorder have been found, including PPIB, which forms one subunit of the prolyl 3-hydroxylase enzyme complex. Patients with OI caused by PPIB mutation should have appropriate early and regular management of their hearing.
TMPY-01487	COCH Protein, Human, Recombinant (His) COCH5B2,COCH-5B2,DFNA9,cochlin	Human	HEK293 Cells
	Cochlin, also known as COCH-5B2 and COCH, is a secreted protein that contains one LCCL domain and two VWFA domains. It is an abundant inner ear protein expressed as multiple isoforms. Its function is also unknown, but it is suspected to be an extracellular matrix component. Cochlin and type II collagen are major constituents of the inner ear extracellular matrix, and Cochlin constitutes 70% of non-collagenous protein in the inner ear, the cochlin isoforms can be classified into three subgroups, ...
TMPY-02242	Serpin B6 Protein, Human, Recombinant (His) DKFZp686I04222,PTI,SPI3,PI-6,RP1-90J20.6,serpin peptidase in...	Human	Baculovirus Insect Cells
	SerpinB6, also known as Cytoplasmic antiproteinase, Peptidase inhibitor 6, Placental thrombin inhibitor, SERPINB6 and PI-6, is a cytoplasm protein that belongs to the serpin family and Ov-serpin subfamily. SerpinB6 / PI-6 is an inhibitor of cathepsin G, kallikrein-8 and thrombin. It may play an important role in the inner ear in the protection against leakage of lysosomal content during stress and loss of this protection results in cell death and sensorineural hearing loss. SerpinB6 / PI-6 is ex...
TMPY-03385	FKBP14 Protein, Human, Recombinant (His) IPBP12,EDSKMH,FK506 binding protein 14, 22 kDa,FKBP22	Human	HEK293 Cells
	FKBP14 belongs to the FK506-binding protein family. It contains 2 EF-hand domains and one PPIase FKBP-type domain. FKBP14 can be detected in the lumen of the endoplasmic reticulum where it is thought to accelerate the folding of proteins during protein synthesis. Truncation of the amino-terminus of FKBP14 significantly decreases peptidyl prolyl cis-trans isomerase activity, therefore implicating that the PPIase FKBP-type domain must be located at the N-terminus. Defects in FKBP14 can cause Ehler...
TMPH-01297	DDR1 Protein, Human, Recombinant (aa 21-417, His) EDDR1,MCK-10,Epithelial discoidin domain-containing receptor...	Human	HEK293 Cells
	Tyrosine kinase that functions as cell surface receptor for fibrillar collagen and regulates cell attachment to the extracellular matrix, remodeling of the extracellular matrix, cell migration, differentiation, survival and cell proliferation. Collagen binding triggers a signaling pathway that involves SRC and leads to the activation of MAP kinases. Regulates remodeling of the extracellular matrix by up-regulation of the matrix metalloproteinases MMP2, MMP7 and MMP9, and thereby facilitates cell...
TMPY-02769	RNASET2 Protein, Human, Recombinant (His) bA514O12.3,RP11-514O12.3,RNASE6PL,ribonuclease T2	Human	Baculovirus Insect Cells
	RNASET2 (ribonuclease T2) is an enzyme that belongs to the RNase T2 family. It is highly expressed in the temporal lobe and fetal brain. RNASET2 gene is a novel member of the Rh/T2/S-glycoprotein class of extracellular ribonucleases. It is a single copy gene that maps to 6q27, a region associated with human malignancies and chromosomal rearrangement. Defects in RNASET2 are the cause of leukoencephalopathy cystic without megalencephaly. An infantile-onset syndrome of cerebral leukoencephalopathy....
TMPY-02176	Harmonin/USH1C Protein, Human, Recombinant (His) PDZD7C,PDZ-73,PDZ73,DFNB18A,PDZ-73/NY-CO-38,DFNB18,NY-CO-37,...	Human	E. coli
	Harmonin, also known as Antigen NY-CO-38 / NY-CO-37, Autoimmune enteropathy-related antigen AIE-75, Protein PDZ-73, Renal carcinoma antigen NY-REN-3, Usher syndrome type-1C protein and USH1C, is a protein that is expressed in small intestine, colon, kidney, eye and weakly in pancreas. USH1C is expressed also in vestibule of the inner ear. USH1C contains 3 PDZ (DHR) domains. USH1C may be involved in protein-protein interaction. Defects in USH1C are the cause of Usher syndrome type 1C (USH1C), als...
TMPY-02495	p19 INK4d Protein, Human, Recombinant (GST) p19-INK4D,INK4D,cyclin-dependent kinase inhibitor 2D (p19, i...	Human	E. coli
	Cyclin-dependent kinase inhibitor 2D(also known as CDKN2D or p19ink4d), a member of the INK4 family of cyclin-dependent kinase (CDK) inhibitors, negatively regulates the cyclin D-CDK4/6 complexes, which promote G1/S transition by phosphorylating the retinoblastoma tumor-suppressor gene product. It is clearly shown that DNA repair is the main target of p19ink4d effect and that diminished apoptosis is a downstream event. Experiments has uncovered a role of p19INK4d as a regulator of DNA-damage-ind...

重组蛋白

ALR Protein, Human, Recombinant (His)

Cat.No: TMPY-00368

Species: Human

Expression System: HEK293 Cells

CIB2 Protein, Human, Recombinant (His)

Cat.No: TMPY-02289

Species: Human

Expression System: E. coli

Serpin B6 Protein, Human, Recombinant (E. coli, His)

Cat.No: TMPJ-00243

Species: Human

Expression System: E. coli

Cyclophilin B Protein, Human, Recombinant (His)

Cat.No: TMPY-01380

Species: Human

Expression System: HEK293 Cells

COCH Protein, Human, Recombinant (His)

Cat.No: TMPY-01487

Species: Human

Expression System: HEK293 Cells

Serpin B6 Protein, Human, Recombinant (His)

Cat.No: TMPY-02242

Species: Human

Expression System: Baculovirus Insect Cells

FKBP14 Protein, Human, Recombinant (His)

Cat.No: TMPY-03385

Species: Human

Expression System: HEK293 Cells

DDR1 Protein, Human, Recombinant (aa 21-417, His)

Cat.No: TMPH-01297

Species: Human

Expression System: HEK293 Cells

RNASET2 Protein, Human, Recombinant (His)

Cat.No: TMPY-02769

Species: Human

Expression System: Baculovirus Insect Cells

Harmonin/USH1C Protein, Human, Recombinant (His)

Cat.No: TMPY-02176

Species: Human

Expression System: E. coli

p19 INK4d Protein, Human, Recombinant (GST)

Cat.No: TMPY-02495

Species: Human

Expression System: E. coli

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