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Search Results for " glaucoma "

Targets Recommended: Carbonic Anhydrase

108

抑制剂 & 化合物

6

天然产物

3

重组蛋白

3

同位素标记化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T6781	Benzenesulfonamide Benzenesulphonamide,苯磺酰胺,Phenyl sulfonamide,Benzosulfonamide	Carbonic Anhydrase	Metabolism
	Benzenesulfonamide (Benzosulfonamide) 是碳酸酐酶的抑制剂。
T14960	Chroman 1	ROCK	Cell Cycle/Checkpoint; Cytoskeletal Signaling; Stem Cells
	Chroman 1 是高效的的ROCK 选择性抑制剂，对 ROCK2 (IC50=1 pM) 的抑制作用强于 ROCK1 (IC50=52 pM) 。它对MRCK 也有抑制作用，IC50为 150 nM。
T0142	Brinzolamide 布林佐胺,AL-4862	Carbonic Anhydrase	Metabolism
	Brinzolamide (AL-4862) 是一种碳酸酐酶(carbonic anhydrase)II 抑制剂(IC50:3.19 nM)。
T6469	Dichlorphenamide Diclofenamide,双氯非那胺,二氯苯二磺胺,Daranide,Antidrasi	Carbonic Anhydrase	Metabolism
	Dichlorphenamide (Diclofenamide) 是一种碳酸酐酶抑制剂。
T0106	Methazolamide L584601,醋甲唑胺,CL 8490	Carbonic Anhydrase	Metabolism
	Methazolamide (CL 8490) 是一种磺胺衍生物，用作碳酸酐酶 (carbonic anhydrase) 抑制剂，对人 carbonic anhydrase II 的 Ki=为 14 nM。它是降低眼压的药物，能够抑制由青光眼及其他眼病引起的眼压升高的作用。
T23782	Benzolamide CL-11366,W 1803,CL 11366,CL11366,苯唑拉胺,W-1803	Carbonic Anhydrase	Metabolism
	Benzolamide (CL 11366) 是碳酸酐酶 (CA) 抑制剂，抑制hCA I(Ki:15 nM)、hCA II(Ki:9 nM)、EcoCAγ(Ki:94 nM)、VchCAγ(Ki:78 nM)、CAS3(Ki:54 nM)。它可用于研究青光眼和癫痫。
T20743	TG-46 TG46,TG 46	FLT; JAK	Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells; Tyrosine Kinase/Adaptors
	TG-46 (TG46) 对 JAK2, FLT3, RET, JAK3 具有抑制作用，可用于研究青光眼。
T0445	Promethazine Proazamine,异丙嗪,Diphergan	CaMK; Dopamine Receptor; 5-HT Receptor; Adrenergic Receptor; AChR; Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Promethazine (Proazamine) 是抗青光眼前列腺素（PG）的类似物。
T68402	Falintolol Falintololum	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Falintolol 是一种新型β-肾上腺素能拮抗剂，具有降压作用，可用于研究青光眼。
T6408	Betaxolol Kerlone,SL 75212,Betoptic,倍他洛尔	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Betaxolol (Kerlone) 是 β1 肾上腺素受体阻断剂，可用于研究高血压和青光眼。
T19528	Propionylcarnitine Propionyl carnitine	Others	Others
	Propionylcarnitine (Propionyl carnitine) 是一种被广泛使用的膳食补充剂，有青光眼和难道破裂有关。
T8580	Bupranolol	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Bupranolol 是竞争性的、口服活性的、非选择性的β-adrenoceptor 拮抗剂，无固有的拟交感神经活性。
T32985	LX-7101 hydrochloride LX7101 hydrochloride,LX 7101 hydrochloride	ROCK; LIM Kinase; PKA	Cell Cycle/Checkpoint; Cytoskeletal Signaling; Stem Cells; Tyrosine Kinase/Adaptors
	LX-7101 hydrochloride是高效的 LIMK 和 ROCK2 抑制剂，具有降压活性，抑制 LIMK1/2, ROCK, PKA，可用于研究青光眼。
T7213	Demecarium bromide 地美溴铵,BC-48	AChE	Neuroscience
	Demecarium bromide (BC-48) 是一种有效的cholinesterase 抑制剂，Kiapp=0.15 μM，它可用研究于青光眼。
T19870	Aceclidine 3-Acetoxyquinuclidine,1-azabicyclo[2.2.2]octan-3-yl acetate,NSC657843,3-quinuclidinyl acetate,NSC-657843,Glaucostat,NSC 657843,Quinuclidin-3-yl acetate	AChR	Neuroscience
	Aceclidine (1-azabicyclo[2.2.2]octan-3-yl acetate) 是M3 mAChR 的调节剂，可用于有关通过降低眼内压治疗青光眼的研究。
T31731	Evodenoson DE 112,DE-112,ATL 313,DE112,ATL313,ATL-313	Adenosine Receptor	GPCR/G Protein; Neuroscience
	Evodenoson (ATL313) 是一种有效的选择性腺苷 A2a 受体(A2aR)激动剂，可用于治疗眼部疾病、肿瘤和免疫系统疾病，可用于研究开角型青光眼和血液肿瘤。
T34914	Trabodenoson INNO-8875,INO-8875,PJ875,PJ-875,INNO 8875,INNO8875,PJ 875	Adenosine Receptor	GPCR/G Protein; Neuroscience
	Trabodenoson (INO-8875) 是一种具有选择性和有效性的的腺苷 A1 受体激动剂，是一种腺苷类似物，可用于研究原发性开角型青光眼。
T9847	TLC2976-0103	Others	Others
	ROCK1-IN-1 是一种ROCK1抑制剂，Ki 值为 540 nM。ROCK1-IN-1 可用于高血压、青光眼、勃起功能障碍的研究。
T16132	MRE3008F20	cAMP; Adenosine Receptor	GPCR/G Protein; Neuroscience
	MRE3008F20 是一种具有种属选择性和高效性的腺苷 A3 受体（AA3R）拮抗剂，抑制 Cl-IB-MECA 诱导的 cAMP 的产生，可用于研究青光眼和哮喘。
T20157	Brimonidine AGN190342,溴莫尼定,Bromoxidine,AGN 190342,AGN-190342	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Brimonidine (Bromoxidine) 是一种完全的α2肾上腺素受体激动剂。
T6422	Brimonidine Tartrate AGN190342 tartrate,304 tartrate,酒石酸溴莫尼定,AGN190342 (tartrate),UK 14304 (tartrate),UK14304 tartrate	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Brimonidine Tartrate (AGN190342 tartrate) 是一种 alpha2 Adrenergic Receptor (alpha2-AR) 受体激动剂。
T16389	Omidenepag UR-7276	Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation
	Omidenepag (UR-7276) 是一种具有选择性和高效性的前列腺素 E2 受体 2 (EP2)激动剂，也是一种新型局部眼部降压药。Omidenepag可用于研究青光眼和高眼压症。
T0103	Dipivefrin hydrochloride 盐酸地匹福林,Dipivefrin HCL	Adrenergic Receptor; AChR	GPCR/G Protein; Neuroscience
	Dipivefrin hydrochloride (Dipivefrin HCl) 是抗青光眼前体药物，被角膜中的酯酶水解为其活性化合物肾上腺素。
T2538	Bimatoprost AGN 192024,比马前列素	Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation
	Bimatoprost (AGN 192024) 是一种氯前列醇衍生的酰胺，用作治疗开角型青光眼和高眼压症的抗高血压药。
T3174	Taprenepag CP-544326	Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation
	Taprenepag (CP-544326) 是一种有效的选择性前列腺素 E2 受体激动剂，EC50为 2.8 nM，可用于研究开角治疗高眼压和青光眼的试验。
T6565	Levobetaxolol hydrochloride Betaxon,左旋倍他洛尔,(S)-Betaxolol hydrochloride,AL-1577A,Levobetaxolol HCl	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Levobetaxolol hydrochloride ((S)-Betaxolol hydrochloride) 是 β-肾上腺素能受体抑制剂 (β阻滞剂) 。它具有降低眼压的作用，可用于研究青光眼。
T71138L	Binospirone MDL 73005EF	5-HT Receptor	GPCR/G Protein; Neuroscience
	Binospirone (MDL 73005EF) 是一种 5-HT1A 受体激动剂，具有抗焦虑活性，可用于研究青光眼和与神经功能障碍相关的运动障碍。
T5841	Travoprost 曲伏前列素,Flu-Ipr,Fluprostenol isopropyl ester,AL6221	Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation
	Travoprost (Fluprostenol isopropyl ester) 是一种异丙基酯前药，是一种高亲和力的，选择性的 FP 前列腺素全受体激动剂。它能够降低眼压，有潜力应用于青光眼和眼高压。
T60351	Acetazolamide sodium OT-302 sodium	Carbonic Anhydrase	Metabolism
	Acetazolamide sodium (OT-302 sodium) 是一种高效的碳酸酐酶 (CA)IX抑制剂，具有利尿、抗淋球菌和降压活性，可用于癫痫、青光眼、水肿和高原反应等适应症。
T21371	Apraclonidine hydrochloride Iopidine,ALO 2145,Apraclonidina,P-aminoclonidine,4-Aminoclonidine,Apraclonidine HCl,Apraclonidinum	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Apraclonidine hydrochloride (ALO 2145) 是一种 α2-肾上腺素能激动剂和弱的 α-1 肾上腺素能受体激动剂。 Apaclonidine hydrochloride 可降低人眼的眼内压，可用于青光眼治疗的研究。
T76828	Sonepcizumab LT 1009	LPL Receptor	GPCR/G Protein
	Sonepcizumab (LT 1009) 是一种完全人源化的抗 S1P 单克隆抗体。Sonepcizumab 具有抗癌活性，可用于研究转移性肾细胞癌 (mRCC) ，可预防青光眼滤过手术后的眼部瘢痕形成。
T15719	Latanoprostene bunod LBN,NCX116	Others	Others
	Latanoprostene bunod (LBN) 是一氧化氮 (NO) 供体前列腺素 F2a 类似物，有用于开角型青光眼或高眼压 (OHT) 患者降低眼压 (IOP) 的局部眼科的研究潜力。
T77513	2-Chlorophenylboronic acid	FAAH	Metabolism; Neuroscience
	2-Chlorophenylboronic acid 是一种单卤代苯硼酸，是一种重要的医药中间体，在新药合成中应用广泛。2-Chlorophenylboronic acid 对脂肪酸酰胺酶有抑制作用，Ki 值为0.01-1 µM，可用于研究抑郁症、青光眼、神经性疼痛、焦虑、偏头痛、I 型糖尿病和胃炎等疾病。
T29708	Aganepag isopropyl AGN-210961,AGN 210961,AGN210961	Others	Others
	Aganepag isopropyl can be used to treat Glaucoma.
T32699	Levobunolol Levobunololum,Liquifilm,AK-Beta,Betegan	Others	Others
	Levobunolol is a nonselective beta-blocker. It is used topically to treat glaucoma.
T0103L	Dipivefrin K 30081,K-30081,Dipivefrinum,Dipivefrina,K30081	Others	Others
	Dipivefrin is a prodrug of epinephrine, and is used to treat open-angle glaucoma.
T28457	Proxodolol hydrochloride	Others	Others
	Proxodolol, a β-adrenergic receptor antagonist, is used potentially for the treatment of glaucoma, hypertension and angina.
T71249	NCX-278	Others	Others
	NCX-278 is a ROCK inhibitor and NO-donating anti-glaucoma agent.
T27518	GW-876167 PRX-00933,PNU-183933,GW876167,BVT933,BVT-933	Others	Others
	GW-876167, a 5-HT2C agonist, is used potentially for the treatment of obesity and glaucoma.
T29811	AL-16049 AL 16049,AL16049	Others	Others
	AL-16049 is an FP-Class prostaglandin analog which may be useful in the treatment of glaucoma and ocular hypertension.
T22743	Dorzolamide	Others	Others
	Dorzolamide is an anti-glaucoma agent and is a carbonic anhydrase inhibitor.
T34644	Simenepag isopropyl AGN210669,AGN-210669,AGN 210669	Others	Others
	Simenepag isopropyl can be used for the treatment of Glaucoma, Ocular Hypertension.
T31600	Echothiophate Iodide Phospholine iodide,Ecostigmini Sodidum,Iodide, Echothiophate,Echodide,Ecothiophate iodide	Others	Others
	Echothiophate iodide is an effective long-acting cholinesterase inhibitor for the treatment of glaucoma.
T71250	NCX-274	Others	Others
	NCX-274 is a ROCK inhibitor and NO-donating anti-glaucoma agent
T31054	CP-432 CP432,CP734432,CP 734432,CP-734432	Others	Others
	CP-432 (CP-734432) is an EP4 prostaglandin agonist for the treatment of glaucoma and ocular hypertension.
T20644	Unoprostone isopropyl UF021,Rescula,UF-021,UF 021	Others	Others
	Unoprostone isopropyl, a prostanoid and synthetic docosanoid, is approved for the treatment of ocular hypertension and open-angle glaucoma.
T19682	Levobetaxolol (S)-(-)-Betaxolol,(S)-Betaxolol	Others	Others
	Levobetaxolol, also known as AL-1577A and Betaxon, is a cardioselective β-adrenergic receptor inhibitor. It has been demonstrated to reduce intraocular pressure in patients affected by ocular hypertension and primary open-angle glaucoma.
T27739	KR-31378 MSH1001,DNB 001,DNB-001,DNB001,MSH-1001,KR31378	Others	Others
	KR-31378, a K(ATP) channel activator, is used potentially for the treatment of ocular hypertension and glaucoma.
T68756	Naboctate	Others	Others
	Naboctate is a synthetic cannabinoid receptor agonist. It has antiemetic, sedative, anxiolytic and anti-glaucoma properties.
T71120	AR-13503	Others	Others
	AR-13503, is an metabolite of Netarsudil (AR-11324), is a Rho-associated protein kinase inhibitor. Netarsudil is potential useful for treating glaucoma and/or reducing intraocular pressure.

化合物

Benzenesulfonamide

Cat.No: T6781

Synonym: Benzenesulphonamide,苯磺酰胺,Phenyl sulfonamide,Benzosulfonamide

Target: Carbonic Anhydrase

Cat.No: T14960

Target: ROCK

Cat.No: T0142

Synonym: 布林佐胺,AL-4862

Target: Carbonic Anhydrase

Dichlorphenamide

Cat.No: T6469

Synonym: Diclofenamide,双氯非那胺,二氯苯二磺胺,Daranide,Antidrasi

Target: Carbonic Anhydrase

Cat.No: T0106

Synonym: L584601,醋甲唑胺,CL 8490

Target: Carbonic Anhydrase

Cat.No: T23782

Synonym: CL-11366,W 1803,CL 11366,CL11366,苯唑拉胺,W-1803

Target: Carbonic Anhydrase

Cat.No: T20743

Synonym: TG46,TG 46

Target: FLT, JAK

Cat.No: T0445

Synonym: Proazamine,异丙嗪,Diphergan

Target: CaMK, Dopamine Receptor, 5-HT Receptor, Adrenergic Receptor, AChR, Histamine Receptor

Cat.No: T68402

Synonym: Falintololum

Target: Adrenergic Receptor

Cat.No: T6408

Synonym: Kerlone,SL 75212,Betoptic,倍他洛尔

Target: Adrenergic Receptor

Propionylcarnitine

Cat.No: T19528

Synonym: Propionyl carnitine

Target: Others

Cat.No: T8580

Target: Adrenergic Receptor

LX-7101 hydrochloride

Cat.No: T32985

Synonym: LX7101 hydrochloride,LX 7101 hydrochloride

Target: ROCK, LIM Kinase, PKA

Demecarium bromide

Cat.No: T7213

Synonym: 地美溴铵,BC-48

Target: AChE

Cat.No: T19870

Synonym: 3-Acetoxyquinuclidine,1-azabicyclo[2.2.2]octan-3-yl acetate,NSC657843,3-quinuclidinyl acetate,NSC-657843,Glaucostat,NSC 657843,Quinuclidin-3-yl acetate

Target: AChR

Cat.No: T31731

Synonym: DE 112,DE-112,ATL 313,DE112,ATL313,ATL-313

Target: Adenosine Receptor

Cat.No: T34914

Synonym: INNO-8875,INO-8875,PJ875,PJ-875,INNO 8875,INNO8875,PJ 875

Target: Adenosine Receptor

Cat.No: T9847

Target: Others

Cat.No: T16132

Target: cAMP, Adenosine Receptor

Cat.No: T20157

Synonym: AGN190342,溴莫尼定,Bromoxidine,AGN 190342,AGN-190342

Target: Adrenergic Receptor

Brimonidine Tartrate

Cat.No: T6422

Synonym: AGN190342 tartrate,304 tartrate,酒石酸溴莫尼定,AGN190342 (tartrate),UK 14304 (tartrate),UK14304 tartrate

Target: Adrenergic Receptor

Cat.No: T16389

Synonym: UR-7276

Target: Prostaglandin Receptor

Dipivefrin hydrochloride

Cat.No: T0103

Synonym: 盐酸地匹福林,Dipivefrin HCL

Target: Adrenergic Receptor, AChR

Cat.No: T2538

Synonym: AGN 192024,比马前列素

Target: Prostaglandin Receptor

Cat.No: T3174

Synonym: CP-544326

Target: Prostaglandin Receptor

Levobetaxolol hydrochloride

Cat.No: T6565

Synonym: Betaxon,左旋倍他洛尔,(S)-Betaxolol hydrochloride,AL-1577A,Levobetaxolol HCl

Target: Adrenergic Receptor

Cat.No: T71138L

Synonym: MDL 73005EF

Target: 5-HT Receptor

Cat.No: T5841

Synonym: 曲伏前列素,Flu-Ipr,Fluprostenol isopropyl ester,AL6221

Target: Prostaglandin Receptor

Acetazolamide sodium

Cat.No: T60351

Synonym: OT-302 sodium

Target: Carbonic Anhydrase

Apraclonidine hydrochloride

Cat.No: T21371

Synonym: Iopidine,ALO 2145,Apraclonidina,P-aminoclonidine,4-Aminoclonidine,Apraclonidine HCl,Apraclonidinum

Target: Adrenergic Receptor

Cat.No: T76828

Synonym: LT 1009

Target: LPL Receptor

Latanoprostene bunod

Cat.No: T15719

Synonym: LBN,NCX116

Target: Others

2-Chlorophenylboronic acid

Cat.No: T77513

Target: FAAH

Aganepag isopropyl

Cat.No: T29708

Synonym: AGN-210961,AGN 210961,AGN210961

Target: Others

Cat.No: T32699

Synonym: Levobunololum,Liquifilm,AK-Beta,Betegan

Target: Others

Cat.No: T0103L

Synonym: K 30081,K-30081,Dipivefrinum,Dipivefrina,K30081

Target: Others

Proxodolol hydrochloride

Cat.No: T28457

Target: Others

Cat.No: T71249

Target: Others

Cat.No: T27518

Synonym: PRX-00933,PNU-183933,GW876167,BVT933,BVT-933

Target: Others

Cat.No: T29811

Synonym: AL 16049,AL16049

Target: Others

Cat.No: T22743

Target: Others

Simenepag isopropyl

Cat.No: T34644

Synonym: AGN210669,AGN-210669,AGN 210669

Target: Others

Echothiophate Iodide

Cat.No: T31600

Synonym: Phospholine iodide,Ecostigmini Sodidum,Iodide, Echothiophate,Echodide,Ecothiophate iodide

Target: Others

Cat.No: T71250

Target: Others

Cat.No: T31054

Synonym: CP432,CP734432,CP 734432,CP-734432

Target: Others

Unoprostone isopropyl

Cat.No: T20644

Synonym: UF021,Rescula,UF-021,UF 021

Target: Others

Cat.No: T19682

Synonym: (S)-(-)-Betaxolol,(S)-Betaxolol

Target: Others

Cat.No: T27739

Synonym: MSH1001,DNB 001,DNB-001,DNB001,MSH-1001,KR31378

Target: Others

Cat.No: T68756

Target: Others

Cat.No: T71120

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
TN1540	Cyanidin-3,5-O-diglucoside chloride	Others	Others
	Cyanidin-3,5-O-diglucoside chloride 具有抗氧化活性。 Cyanidin-3,5-O-diglucoside 抑制高压诱导的 GLAST 降低，可用于青光眼研究。 Cyanidin-3,5-O-diglucoside chloride 在 >40°C 的温度下很容易通过水解和/或氢化降解。
T1287	Synephrine 辛弗林,Oxedrine	Endogenous Metabolite; Adrenergic Receptor	GPCR/G Protein; Metabolism; Neuroscience
	Synephrine (Oxedrine) 是来自 Citrus aurantium 的α-adrenergic 和β-adrenergic 激动剂，是一种生物碱。它也是一种拟交感神经化合物，能够用于减肥。
T1231	Pilocarpine nitrate 匹鲁卡品硝酸盐,Pilagan,硝酸毛果芸香碱,Pilofrin	AChR	Neuroscience
	Pilocarpine nitrate (Pilagan) 是 M3 型毒蕈碱乙酰胆碱受体激动剂，可用于治疗青光眼。
TN1465	Cannabigerol	NOS; 5-HT Receptor; ROS	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Cannabigerol 是一种植物大麻素，是一种高亲和力 α2-肾上腺素能受体激动剂、中度亲和力 5-HT1A 受体拮抗剂和低亲和力 CB1/CB2受体拮抗剂。它可降低眼压，有潜力治疗青光眼。
T39168	Epsilon-(gamma-glutamyl)-lysine Epsilon-(gamma-glutamyl)-lysine,γ-Glu-ε-Lys,H-Glu(H-Lys-OH)-OH	Others	Others
	Epsilon-(gamma-glutamyl)-lysine is an N(6)-acyl-L-lysine derivative that forms bonds between extracellular matrix (ECM) components with the assistance of the enzyme tissue transglutaminase (tTg). These bonds are implicated in the pathogenesis of certain diseases like non-diabetic kidney and glaucoma filtration.
T20636	Latrunculin B LAT-B,LATB,NSC 339663,NSC339663,NSC-339663,LAT B,INS115644	Antifungal	Microbiology/Virology
	Latrunculin B 是一种来自红海海绵的生物碱，是一种肌动蛋白聚合 (actin polymerization) 抑制剂，具有抗真菌和抗原生动物活性。Latrunculin B 调节肺静脉电生理特征并减轻牵张性心律失常的发生，可用于研究青少年青光眼。

天然产物

Cyanidin-3,5-O-diglucoside chloride

Cat.No: TN1540

Target: Others

Cat.No: T1287

Synonym: 辛弗林,Oxedrine

Target: Endogenous Metabolite, Adrenergic Receptor

Pilocarpine nitrate

Cat.No: T1231

Synonym: 匹鲁卡品硝酸盐,Pilagan,硝酸毛果芸香碱,Pilofrin

Target: AChR

Cat.No: TN1465

Target: NOS, 5-HT Receptor, ROS

Epsilon-(gamma-glutamyl)-lysine

Cat.No: T39168

Synonym: Epsilon-(gamma-glutamyl)-lysine,γ-Glu-ε-Lys,H-Glu(H-Lys-OH)-OH

Target: Others

Cat.No: T20636

Synonym: LAT-B,LATB,NSC 339663,NSC339663,NSC-339663,LAT B,INS115644

Target: Antifungal

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-02248	Myocilin Protein, Human, Recombinant (His) myocilin, trabecular meshwork inducible glucocorticoid respo...	Human	HEK293 Cells
	Myocilin, also known as Trabecular meshwork-induced glucocorticoid response protein, MYOC, and GLC1A, is a protein that contains one olfactomedin-like domain. Myocilin / MYOC may participate in the obstruction of fluid outflow in the trabecular meshwork. Myocilin / MYOC is expressed in large amounts in various types of muscle, ciliary body, papillary sphincter, skeletal muscle, heart, and other tissues. Myocilin / MYOC is expressed predominantly in the retina. In normal eyes, it is found in the ...
TMPY-03501	Optineurin Protein, Human, Recombinant (His & GST) optineurin,HIP7,ALS12,HYPL,TFIIIA-INTP,FIP2,NRP,GLC1E	Human	Baculovirus Insect Cells
	OPTN (Optineurin) is a Protein Coding gene. The Optineurin gene encodes the coiled-coil containing protein optineurin. Optineurin is a multifunctional adaptor protein intimately involved in various vesicular trafficking pathways. Through interactions with an array of proteins, such as myosin VI, huntingtin, Rab8, and Tank-binding kinase 1, as well as via its oligomerization, optineurin can act as an adaptor, scaffold, or signal regulator to coordinate many cellular processes associated with the ...
TMPJ-00680	ANGPTL7 Protein, Human, Recombinant (His) CDT6,Cornea-derived transcript 6 protein,Angiopoietin-like p...	Human	HEK293 Cells
	Angiopoietin-like 7 (ANGPTL7) is a secreted glycoprotein that is structurally related to the angiopoietins. Members of this protein family contain an N-terminal coiled coil domain and a C-terminal fibrinogen-like domain. ANGPTL7 shares 89% aa sequence identity with mouse and rat ANGPTL7. It is secreted as a 45-50kDa monomer that forms disulfide-linked homotrimers and tetramers via the coiled coil domain. ANGPTL7 is expressed in the corneal stroma, trabecular meshwork, and sclera and is elevated ...

重组蛋白

Myocilin Protein, Human, Recombinant (His)

Cat.No: TMPY-02248

Species: Human

Expression System: HEK293 Cells

Optineurin Protein, Human, Recombinant (His & GST)

Cat.No: TMPY-03501

Species: Human

Expression System: Baculovirus Insect Cells

ANGPTL7 Protein, Human, Recombinant (His)

Cat.No: TMPJ-00680

Species: Human

Expression System: HEK293 Cells

Cat. No.	Product Name	Target	Signaling Pathways
T10544	Bimatoprost D5 AGN 192024 D5	Others	Others
	Bimatoprost (AGN 192024) D5 is a deuterium-labeled Bimatoprost. Bimatoprost is a topical hypotensive agent frequently used for treating glaucoma and ocular hypertension.
T70186	Methazolamide-d6
	Methazolamide-d6 is intended for use as an internal standard for the quantification of methazolamide by GC- or LC-MS. Methazolamide is a carbonic anhydrase inhibitor. It reduces intraocular pressure and cerebrospinal fluid flow in a rat model of glaucoma. Methazolamide reduces electroshock-induced seizures in rats with an ED50 value of 19.2 mg/kg. It also inhibits production of reactive oxygen species (ROS) in a primary cortical neuron (PCN) cellular model of subarachnoid hemorrhage (SAH) and re...
T36059	Dichlorphenamide-13C6 Dichlorphenamide-13C6
	Dichlorphenamide-13C6is intended for use as an internal standard for the quantification of dichlorphenamide by GC- or LC-MS. Dichlorphenamide is a sulfonamide and an orally bioavailable carbonic anhydrase (CA) inhibitor (Kis = 1.20, 38, 50, and 50 nM for the human CA isoforms CAI, CAII, CAIX, and CAXII, respectively).1It lowers intraocular pressure in rabbits when 50 μl of a 10% solution is applied topically to the eye.2Dichlorphenamide rescues the potassium deficiency and prevents insulin-induc...

同位素标记化合物

Cat.No: T10544

Synonym: AGN 192024 D5

Target: Others

Methazolamide-d6

Cat.No: T70186

Dichlorphenamide-13C6

Cat.No: T36059

Synonym: Dichlorphenamide-13C6

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