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Search Results for " extravasation "

Targets Recommended: 5-HT Receptor

12

抑制剂 & 化合物

1

天然产物

4

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T1092	Zolmitriptan 佐米曲普坦,311C90,BW-311C90	5-HT Receptor	GPCR/G Protein; Neuroscience
	Zolmitriptan (311C90) 是一种5-HT1B/1D 受体部分激动剂，可用于偏头痛的研究，对 5-HT1B、5-HT1D、5-HT1F 受体的Ki 分别为 5.01、0.63 和 63.09 nM。
T26781	BF-1 BF1,BF 1	5-HT Receptor	GPCR/G Protein; Neuroscience
	BF-1是一种新型选择性 5-HT2 受体拮抗剂，通过阻断间氯苯基哌嗪（mCPP）或BW723C86诱导的神经源性硬脑膜血浆蛋白外渗发挥作用。BF-1 可用于研究偏头痛。
T7340	5'-N-Ethylcarboxamidoadenosine NECA,5'-N-乙基酰胺基腺苷	Adenosine Receptor	GPCR/G Protein; Neuroscience
	5'-N-Ethylcarboxamidoadenosine (NECA) 是腺苷受体的激动剂，可增加荧光素和低分子量葡聚糖的脑外渗，与血脑屏障调节无关。
T70248	4991W93	Others	Others
	4991W93 is a 5HT(1B/1D) receptor partial agonist, inhibiting electrically induced plasma extravasation, blocking neurogenic plasma protein extravasation, inhibiting release of calcitonin gene-related peptide.
T28431	PNU109291 PNU-109291,PNU 109291	Others	Others
	PNU109291, a potent and selective agonist of the 5-HT1D receptor, effectively mitigates dural plasma extravasation induced by trigeminal ganglion stimulation.
T68904	GW-833972A free base	Others	Others
	GW833972 is a CB2 Agonist. GW 833972A inhibited capsaicin-induced depolarization of the human and guinea-pig and prostaglandin E(2) (PGE(2)) and hypertonic saline-induced depolarization of the guinea-pig isolated vagus nerve in vitro. GW 833972A also inhibited citric acid-induced cough but not plasma extravasation in the guinea-pig and this effect was blocked by a CB(2) receptor antagonist.
T27059	CP-122288	Others	Others
	CP-122288 is a potent and selective agonist for the 5-HT1B, 5-HT1D and 5-HT1F serotonin receptor subtypes. CP-122288 is potent as an inhibitor of plasma protein extravasation and neurogenic inflammation.
T83211	Ac2-12 TFA
	Ac2-12 TFA是抑制嗜中性白细胞外渗的膜联蛋白/脂皮质激素1(LC1)模拟肽，具有抗迁移特性，能在实验性炎症模型中阻止嗜中性白细胞的募集。
TP1919	Ac2-12
	Annexin/lipocortin 1-mimetic peptide; inhibits leukocyte extravasation. Reduces neutrophil adhesion and emigration, and promotes detachment of neutrophils from activated mesenteric endothelium in mice in vivo.
TP2083	Ac9-25
	N-terminal peptide of Annexin I (AI/Lipocortin I) that inhibits leukocyte extravasation. Acts as a formyl peptide receptor 1 (FPR1) ligand and stimulates neutrophil NADPH oxidase activation.
TP2104	UFP-803 UFP 803
	Urotensin-II (UT) receptor ligand; behaves as a silent antagonist in most in vitro assays and in vivo, but does retain small residual agonist activity under certain conditions in some assays. Competitively antagonizes U-II induced contractions in the rat
T76841	Enlimomab
	Enlimomab (BI-RR 0001) 是一种针对人 ICAM-1的小鼠 IgG2a 单抗，可抑制白细胞粘附到血管内皮，从而减少白细胞外渗漏和炎症性组织损伤。Enlimomab 具有抗炎作用，可用于中风研究。

化合物

Cat.No: T1092

Synonym: 佐米曲普坦,311C90,BW-311C90

Target: 5-HT Receptor

Cat.No: T26781

Synonym: BF1,BF 1

Target: 5-HT Receptor

5'-N-Ethylcarboxamidoadenosine

Cat.No: T7340

Synonym: NECA,5'-N-乙基酰胺基腺苷

Target: Adenosine Receptor

Cat.No: T70248

Target: Others

Cat.No: T28431

Synonym: PNU-109291,PNU 109291

Target: Others

GW-833972A free base

Cat.No: T68904

Target: Others

Cat.No: T27059

Target: Others

Cat.No: T83211

Cat.No: TP1919

Cat.No: TP2083

Cat.No: TP2104

Synonym: UFP 803

Cat.No: T76841

Cat. No.	Product Name	Target	Signaling Pathways
T1638	N-Acetylneuraminic acid 唾液酸,Acide aceneuramique,N-乙酰神经氨酸,NeuAc,Lactaminic acid	Others; Influenza Virus; Endogenous Metabolite	Metabolism; Microbiology/Virology; Others
	N-Acetylneuraminic acid (Acide aceneuramique) 是一种九碳唾液酸单糖，通常存在于细胞膜上的糖蛋白和哺乳动物细胞中的神经节苷脂等糖脂中。它可用于神经传递、白细胞外渗、病毒或细菌感染以及碳水化合物-蛋白质识别。

天然产物

N-Acetylneuraminic acid

Cat.No: T1638

Synonym: 唾液酸,Acide aceneuramique,N-乙酰神经氨酸,NeuAc,Lactaminic acid

Target: Others, Influenza Virus, Endogenous Metabolite

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-00672	Azurocidin/CAP37 Protein, Human, Recombinant (His) AZU,NAZC,azurocidin 1,hHBP,AZAMP,HUMAZUR,CAP37,HBP,AZU1	Human	HEK293 Cells
	Azurocidin (AZU1), also known as heparin-binding protein (HBP) or cationic antimicrobial protein 37 (CAP37), is an azurophil granule antibiotic protein, with monocyte chemotactic and antibacterial activity. The Azurophil granules, specialized lysosomes of the neutrophil, contain at least 10 proteins implicated in the killing of microorganisms. Azurocidin is a member of the serine protease family that includes Cathepsin G, neutrophil elastase (NE), and proteinase 3 (PR3), however, Azurocidin is n...
TMPJ-00257	PSGL-1/CD162 Protein, Human, Recombinant (hFc) Selectin P ligand,P-selectin glycoprotein ligand 1,SELPLG,CD...	Human	HEK293 Cells
	PSGL-1 (CD162), is a mucintype glycoprotein that plays a key role in leukocyte adhesion. Human PSGL-1 cDNA encodes 412 amino acids (aa). It expressed on neutrophils, monocytes and most lymphocytes. The mature PSGL-1 (aa 42-412) is expressed as a disulfide-linked homodimer that signals intracellularly and promotes integrin activation. PSGL-1 is found on virtually all leukocytes, dendritic cells, platelets, and some endothelial cells. It is primarily responsible for early events in extravasation, ...
TMPJ-00993	CCL5 Protein, Rat, Recombinant (E. coli, His) Small-inducible cytokine A5,SIS-δ,C-C motif chemokine 5,T-ce...	Rat	E. coli
	C-C motif chemokine 5(CCL5) is a β-chemokine that plays a primary role in the inflammatory immune response by means of its ability to attract and activate leukocytes. CCL5 is secreted by many cell types at inflammatory sites, and it exerts a wide range of activities through the receptors CCR1, CCR3, CCR4, and CCR5. Inflammatory responses can be impaired by the sequestration of CCL5 by the cytomegalovirus protein US28. Oligomerization of CCL5 on glycosaminoglycans is required for CCR1mediated leu...
TMPJ-00380	AOC3 Protein, Human, Recombinant (His) Membrane primary amine oxidase,HPAO,VAP-1,Semicarbazide-sens...	Human	HEK293 Cells
	Vascular adhesion protein-1(VAP-1) is a copper amine oxidase with a topaquinone cofactor.VAP-1 is a type II integral membrane protein, but a soluble form of the enzyme is present in human serum, and its level increases in diabetes and some inflammatory liver diseases. VAP-1 catalyzes the oxidative deamination of small primary amines such as methylamine, benzylamine, and aminoacetone in a reaction that produces an aldehyde, ammonia, and H2O2. VAP-1 vascular expression is regulated at sites of inf...

重组蛋白

Azurocidin/CAP37 Protein, Human, Recombinant (His)

Cat.No: TMPY-00672

Species: Human

Expression System: HEK293 Cells

PSGL-1/CD162 Protein, Human, Recombinant (hFc)

Cat.No: TMPJ-00257

Species: Human

Expression System: HEK293 Cells

CCL5 Protein, Rat, Recombinant (E. coli, His)

Cat.No: TMPJ-00993

Species: Rat

Expression System: E. coli

AOC3 Protein, Human, Recombinant (His)

Cat.No: TMPJ-00380

Species: Human

Expression System: HEK293 Cells

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