Ac2-12 TFA, an annexin/lipocortin 1 (LC1)-mimetic peptide, inhibits neutrophil extravasation and demonstrates antimigratory effects by attenuating the recruitment of neutrophils in experimental models of inflammation [1] [2].

Ac2-12 TFA（静脉注射；6.7毫克/公斤，约70纳摩尔每只小鼠），在雄性瑞士白鼠（10-15克）中被发现模拟脂皮质素1（LC1）和Ac2-26的作用[1]。Ac2-12 TFA（100微克）显著减少C57BL/6野生型小鼠多形核白血球（PMN）的迁移，而在FPR KO小鼠中不再活跃[2]。