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Search Results for " dgtp "

Targets Recommended: Nucleoside Antimetabolite/Analog DNA/RNA Synthesis

16

抑制剂 & 化合物

4

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T40192	dGTP 2′-脱氧鸟苷 5′-(四氢三磷酸酯),2'-Deoxyguanosine-5'-triphosphate	Nucleoside Antimetabolite/Analog; DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	dGTP（2'-Deoxyguanosine-5'-triphosphate）作为脱氧核糖核酸（DNA）合成的基本单元，属于鸟苷核苷酸，对8-O-GDP、8-O-dGTP、8-O-GTP及8-O-dGTP的氧化损伤具有高度敏感性。
T36688	Deoxyguanosine triphosphate trisodium salt Deoxyguanosine 5-triphosphate,2'-Deoxyguanosine-5'-triphosphate trisodium salt,dGTP trisodium salt	Nucleoside Antimetabolite/Analog	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	Deoxyguanosine triphosphate trisodium salt (2'-Deoxyguanosine-5'-triphosphate trisodium salt) 是细胞中用于 DNA 合成的核苷酸前体，可用于逆转录聚合酶链反应 (RT-PCR) 中以进行 DNA 扩增。
T84664	Rp-dGTPαS Rp-dGTP-α-S	Others	Others
	Rp-dGTPαS是一个dNTPαS核苷酸的对映异构体，作为SAMHD1的核苷酸底物，参与调节细胞内dNTP水平，从而限制包括HIV-1在内的病毒在CD4+骨髓谱系和静息T细胞中的复制。SAMHD1作为一种四聚体复合物，能够催化Rp-dGTPαS的水解反应，生成2'-脱氧核苷和三磷酸。
T40671	7-Deaza-7-propargylamino-dGTP	Others	Others
	7-Deaza-7-propargylamino-dGTP is an analogue of dGTP, specifically designed for the purpose of gene sequencing.
T40773	7-Deaza-7-propargylamino-3'-azidomethyl-dGTP	Others	Others
	7-Deaza-7-propargylamino-3'-azidomethyl-dGTP is a commonly employed deoxyguanosine triphosphate (dGTP) analog in next generation sequencing (NGS).
T83810	3'-Amino-3'-deoxyguanosine-5'-O-triphosphate sodium 3'-amino-dGTP	Others	Others
	3'-氨基-3'-去氧鸟苷-5'-O-三磷酸（3'-氨基-dGTP）是一种经过胺修饰的核苷酸。它能终止由大肠杆菌中的RNA聚合酶催化的RNA链合成。3'-氨基-dGTP已用于合成报警素鸟苷五磷酸（pppGpp）的一种不可水解衍生物。
T83248	7-Deaza-2′-deoxyguanosine 5′-triphosphate 7-Deaza-2'-dGTP	Telomerase	DNA Damage/DNA Repair
	7-Deaza-2′-deoxyguanosine 5′-triphosphate (7-Deaza-2'-dGTP)为核苷酸类似物，兼具端粒酶抑制活性(IC50为11μM)。
T83831	Sp-2'-Deoxyguanosine-5'-O-(1-thiotriphosphate) sodium Sp-dGTP-α-S	Others	Others
	Sp-2'-Deoxyguanosine-5'-O-(1-thiotriphosphate) 是一种含硫异构体，属于核苷酸三磷酸2'-脱氧鸟苷-5'-O-三磷酸(dGTP)。它通过抑制脱氧核苷酸三磷酸三磷酸水解酶SAMHD1 (Ki = 820 nM)发挥作用。
T83247	7-Deaza-dGTP tetralithium	Others	Others
	7-Deaza-dGTP tetralithium可用于高效扩增富含GC序列的DNA。
T40799	ddGTP 2′,3′-Dideoxyguanosine 5′-triphosphate,ddGTP	Others	Others
	ddGTP (2′,3′-Dideoxyguanosine 5′-triphosphate) is one of 2',3'-dideoxyribonucleoside 5'-triphosphates (ddNTPs) that acts as chain-elongating inhibitor of DNA polymerase for DNA sequencing.
T38529	7-Deaza-7-propargylamino-ddGTP	Others	Others
	7-Deaza-7-propargylamino-ddGTP is a gene sequencing analog of dideoxyguanosine triphosphate (ddGTP).
T74023	ddGTP trisodium	Others	Others
	ddGTP trisodium（2′,3′-Dideoxyguanosine 5′-triphosphate）为一种ddNTPs，用作DNA聚合酶链延长抑制剂，应用于DNA测序。其既是DNA聚合酶α的抑制剂，亦作为反应底物。
T11313	Forodesine hydrochloride BCX-1777 hydrochloride,Immucillin-H hydrochloride	Others	Others
	Forodesine hydrochloride (BCX-1777 hydrochloride), a potent inhibitor of human lymphocyte proliferation, effectively induces apoptosis in leukemic cells by elevating dGTP levels. This compound is an orally active, highly potent purine nucleoside phosphorylase (PNP) inhibitor, demonstrating IC50 values between 0.48 to 1.57 nM across human, mouse, rat, monkey, and dog PNP.
T15337	Forodesine Immucillin-H,BCX-1777	Apoptosis	Apoptosis
	Forodesine (BCX-1777) 是一种具有口服活性和高效性的嘌呤核苷磷酸化酶 (PNP) 抑制剂，是一种新的嘌呤核苷类似物，抑制人类淋巴细胞增殖抑制剂，可通过增加 dGTP 水平而诱导白血病细胞凋亡 (apoptosis)，可用于研究皮肤T细胞淋巴瘤。
T27260	Emivirine MKC442,MKC-442,MKC 442,DRG-0302,DRG 0302,DRG0302	HIV Protease	Microbiology/Virology; Proteases/Proteasome
	Emivirine (MKC-442) 是一种有效和选择性的人类免疫缺陷病毒1型(HIV-1)的非核苷逆转录酶抑制剂。
T35652	2'-Deoxyguanosine 5'-monophosphate (sodium salt hydrate)	Others	Others
	2'-Deoxyguanosine 5'-monophosphate (dGMP) is used as a substrate of guanylate kinases to generate dGDP, which in turn is phosphorylated to dGTP, a nucleotide precursor used in DNA synthesis. In addition, dGMP can be efficiently phosphorylated by the type I thymidylate kinase of the malarial agent P. falciparum. In humans, deficiency of mitochondrial deoxyguanosine kinase, which synthesizes dGMP from ATP and deoxyguanosine, contributes to mitochondrial DNA depletion syndrome.

化合物

Cat.No: T40192

Synonym: 2′-脱氧鸟苷 5′-(四氢三磷酸酯),2'-Deoxyguanosine-5'-triphosphate

Target: Nucleoside Antimetabolite/Analog, DNA/RNA Synthesis

Deoxyguanosine triphosphate trisodium salt

Cat.No: T36688

Synonym: Deoxyguanosine 5-triphosphate,2'-Deoxyguanosine-5'-triphosphate trisodium salt,dGTP trisodium salt

Target: Nucleoside Antimetabolite/Analog

Cat.No: T84664

Synonym: Rp-dGTP-α-S

Target: Others

7-Deaza-7-propargylamino-dGTP

Cat.No: T40671

Target: Others

7-Deaza-7-propargylamino-3'-azidomethyl-dGTP

Cat.No: T40773

Target: Others

3'-Amino-3'-deoxyguanosine-5'-O-triphosphate sodium

Cat.No: T83810

Synonym: 3'-amino-dGTP

Target: Others

7-Deaza-2′-deoxyguanosine 5′-triphosphate

Cat.No: T83248

Synonym: 7-Deaza-2'-dGTP

Target: Telomerase

Sp-2'-Deoxyguanosine-5'-O-(1-thiotriphosphate) sodium

Cat.No: T83831

Synonym: Sp-dGTP-α-S

Target: Others

7-Deaza-dGTP tetralithium

Cat.No: T83247

Target: Others

Cat.No: T40799

Synonym: 2′,3′-Dideoxyguanosine 5′-triphosphate,ddGTP

Target: Others

7-Deaza-7-propargylamino-ddGTP

Cat.No: T38529

Target: Others

ddGTP trisodium

Cat.No: T74023

Target: Others

Forodesine hydrochloride

Cat.No: T11313

Synonym: BCX-1777 hydrochloride,Immucillin-H hydrochloride

Target: Others

Cat.No: T15337

Synonym: Immucillin-H,BCX-1777

Target: Apoptosis

Cat.No: T27260

Synonym: MKC442,MKC-442,MKC 442,DRG-0302,DRG 0302,DRG0302

Target: HIV Protease

2'-Deoxyguanosine 5'-monophosphate (sodium salt hydrate)

Cat.No: T35652

Target: Others

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPH-00568	8-oxo-dGTP diphosphatase Protein, E. coli, Recombinant (His & SUMO) dGTP pyrophosphohydrolase,8-oxo-dGTP dipho...	E. coli	E. coli
	8-oxo-dGTP diphosphatase Protein, E. coli, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 30.9 kDa and the accession number is P08337.
TMPJ-01429	SARS-CoV-2 Guanine-N7 methyltransferase Protein (His) SARS-CoV 2 nsp14,Guanine-N7 methyltransferase,SARS-CoV 2 Exo...	SARS-CoV-2	E. coli
	The nonstructural protein (nsp) 14 of SARS-CoV 2 was identified as a cap (guanine-N7)-methyltransferase (N7-MTase). Nsp14 of coronaviruses two different activities: an exoribonuclease activity acting on both ssRNA and dsRNA in a 3' to 5' direction and a N7-guanine methyltransferase activity. It may be involved in the proof-reading ability during the viral RNA replication and transcription. GTP, dGTP as well as cap analogs GpppG, GpppA and m7GpppG could be methylated by nsp14.
TMPH-03195	Protein archease, Pyrococcus horikoshii, Recombinant (His & Myc) Protein archease	Pyrococcus horikoshii	E. coli
	Activates the tRNA-splicing ligase complex by facilitating the enzymatic turnover of catalytic subunit RtcB. Acts by promoting the guanylylation of RtcB, a key intermediate step in tRNA ligation. Can also alter the NTP specificity of RtcB such that ATP, dGTP or ITP is used efficiently. Protein archease, Pyrococcus horikoshii, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 24.1 kDa and the accession number is O59205...
TMPY-03508	XTP3TPA Protein, Human, Recombinant (His) XTP3TPA,dCTP pyrophosphatase 1,RS21C6,CDA03	Human	E. coli
	DCTPP1 hydrolyzes deoxynucleoside triphosphates (dNTPs) to the corresponding nucleoside monophosphates. It has a strong preference for modified dCTP. DCTPP1’s activity is highest with 5-iodo-dCTP, followed by 5-bromo-dCTP, unmodified dCTP, 5-methyl-dCTP and 5-chloro-dCTP. DCTPP1 also hydrolyzes 2-chloro-dATP and 2-hydroxy-dATP with lower efficiency, and has even lower activity with unmodified dATP, dTTP and dUTP (in vitro). DCTPP1 does not hydrolyze ATP, UTP, ITP, GTP, dADP, dCDP or dGTP....

重组蛋白

8-oxo-dGTP diphosphatase Protein, E. coli, Recombinant (His & SUMO)

Cat.No: TMPH-00568

Species: E. coli

Expression System: E. coli

SARS-CoV-2 Guanine-N7 methyltransferase Protein (His)

Cat.No: TMPJ-01429

Species: SARS-CoV-2

Expression System: E. coli

Protein archease, Pyrococcus horikoshii, Recombinant (His & Myc)

Cat.No: TMPH-03195

Species: Pyrococcus horikoshii

Expression System: E. coli

XTP3TPA Protein, Human, Recombinant (His)

Cat.No: TMPY-03508

Species: Human

Expression System: E. coli

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