23
2
1
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T8391 |
Cesium chloride
氯化铯,CsCl |
Potassium Channel | Membrane transporter/Ion channel |
Cesium chloride (CsCl) 是一种钾通道抑制剂,可以防止 Alloxan 引起的 Na+转运减少。Cesium chloride 可以诱发心律失常。 | |||
T20898 |
(R)-Propranolol hydrochloride
Dexpropranolol hydrochloride,(R)-(+)-Propranolol,盐酸普奈洛尔 |
Adrenergic Receptor | GPCR/G Protein; Neuroscience |
(R)-Propranolol hydrochloride (Dexpropranolol hydrochloride) 是一种抗肾上腺素受体拮抗剂,是一种普萘洛尔的活性较低的对映体。Dexpropranolol 是一种非选择性的β-adrenergic receptor 拮抗剂,对 β1AR 和 β2AR 具有高亲和力。 | |||
T15207 |
Eleclazine hydrochloride
GS 6615 hydrochloride |
Sodium Channel | Membrane transporter/Ion channel |
Eleclazine hydrochloride (GS 6615 hydrochloride) 是新型 Na+电流抑制剂,IC50是0.7 uM。 | |||
T11239 |
Ethacizine hydrochloride
NIK-244,Ethacizin,NIK-244 hydrochloride |
Sodium Channel | Membrane transporter/Ion channel |
Ethacizine hydrochloride (NIK-244) 具有抗心律失常活性,其作用于心脏活动有关,可用于研究心律失常和心肌梗死。 | |||
T29050 |
UK 66914
UK66914,UK-66914 |
Potassium Channel | Membrane transporter/Ion channel |
UK 66914 是一种 K(+)通道阻断剂,可用于研究心律失常。 | |||
T28686 |
SB-237376 HCl
SB-237376 hydrochloride |
Calcium Channel; Sodium Channel | Membrane transporter/Ion channel; Metabolism |
SB-237376 HCl (SB-237376 hydrochloride) 是一种钙和钾通道拮抗剂,可用于治疗心律失常。 | |||
T24021 |
E 0747
E 747,L 29065,E0747,E-0747 |
Sodium Channel | Membrane transporter/Ion channel |
E 0747 (E0747) 是一种新的抗心律失常化合物,通过抑制心脏细胞的Na通道来抑制心律失常。 | |||
T28686L |
SB-237376
|
Calcium Channel; Sodium Channel | Membrane transporter/Ion channel; Metabolism |
SB-237376 是一种钙和钾通道拮抗剂,可用于治疗心律失常。 | |||
T27630 |
Isbogrel
CV4151,CV-4151,CV 4151 |
Prostaglandin Receptor | GPCR/G Protein; Immunology/Inflammation |
Isbogrel (CV4151)是一种小分子血栓素A2合成酶(TXA2 synthase)抑制剂,可用来研究心律失常、短暂性脑缺血发作和血栓形成。 | |||
T25701 |
Levosemotiadil
SD 3212,SA 3212 |
LDL; Calcium Channel | Membrane transporter/Ion channel; Metabolism |
Levosemotiadil(SA 3212) 是一种新型钙拮抗剂,是一种非常有效的低密度脂蛋白氧化抑制剂。Levosemotiadil 可用于预防致死性心律失常。 | |||
T23536 |
Xamoterol hemifumarate
ICI 118587 hemifumarate,Corwin hemifumarate |
Adrenergic Receptor | GPCR/G Protein; Neuroscience |
Xamoterol hemifumarate 是一种具有强效性和选择性的β1-肾上腺素受体激动剂。Xamoterol hemifumarate 是研究心律失常和 β1-肾上腺素能刺激与 IKr 之间关系的潜在化合物。 | |||
T77550 |
O-Desmethyl Quinidine
|
Others | Others |
O-Desmethyl Quinidine 是一种新型的奎尼丁类似物,具有显着的抗心律失常活性和较低的急性毒性,可能有助于治疗心律失常。 | |||
T68164 |
Tolamolol
|
Adrenergic Receptor | GPCR/G Protein; Neuroscience |
Tolamolol 是一种选择性 β肾上腺素能阻滞剂,能显著降低运动诱导的S-T段抑制程度,可用于治疗心律失常。 | |||
T1012 |
Acebutolol hydrochloride
盐酸醋丁洛尔,Acebutolol HCl |
Adrenergic Receptor | GPCR/G Protein; Neuroscience |
Acebutolol hydrochloride (Acebutolol HCl) 是一种 β-肾上腺素受体拮抗剂,用于研究高血压、心绞痛和心律失常。 | |||
T69472 |
Edrophonium
|
Others | Others |
Edrophonium is a rapid-onset, short-acting cholinesterase inhibitor used in cardiac arrhythmias and in the diagnosis of myasthenia gravis. It has also been used as an antidote to curare principles. | |||
T19887 |
Teflurane
Abbott-16900,Tefluranum,Abbott 16900,Teflurano |
Others | Others |
Teflurane is a halocarbon drug, Teflurane was investigated as an inhalational anesthetic, a high incidence of cardiac arrhythmias in patients, similarly to the cases of halopropane and norflurane. | |||
T63330 |
Clamikalant sodium
|
Others | Others |
Clamikalant sodium 是非选择性的、 ATP 敏感性的钾 (KATP) 通道阻滞剂,能够用于研究心律不齐。 | |||
T26875 |
BN 50739
BN50739,BN-50739 |
Others | Others |
BN 50739 is an antagonist of platelet-activating factor (PAF). BN 50739 suppresses certain cardiac arrhythmias. PAF is released from ischaemic myocardium and may contribute to initiation of ischaemia-induced ventricular fibrillation (VF) | |||
T21391 |
Flecainide
Tambocor,Apocard,Flecainida,Flecainidum |
Others | Others |
Flecainide acetate is a class Ic antiarrhythmic agent, it is used to treat a variety of cardiac arrhythmias including paroxysmal atrial fibrillation, paroxysmal supraventricular tachycardia, and ventricular tachycardia. It works by regulating the flow of | |||
T72323 |
Antiarrhythmic agent-1
|
Others | Others |
Antiarrhythmic agent-1 (示例 I) 是一种抗心律失常试剂,也是IKr 钾离子通道抑制剂 (IC50<1 μM)。 | |||
T33579 |
Nafazatrom
Nafazatromum |
Others | Others |
Nafazatrom is a pyrazolinone derivative and lipoxygenase inhibitor that increases endogenous prostacyclin (PGI2) and has experimental anticancer activity. Nafazatrom is also an antithrombotic drug that increases prostacyclin levels and reduces the inciden | |||
T71945 |
Eleclazine free base
|
Others | Others |
Eleclazine, also known as GS-6615, is a selective late sodium current inhibitor. Eleclazine is potentially useful for treatment of coronary vasodilators, antiarrhythmics and vasodilators. Eleclazin showed a shortening of the QTc interval (the time interval between the start of the Q-wave and end of the T-wave in the heart’s electrical cycle) in patients with long QT-3 (LQT3) syndrome. LQT3 is a genetic disorder that prolongs the heart’s QTc interval and can cause life-threatening cardiac arrhyth... | |||
T37297 |
Ru360
|
Others | Others |
Ru360, an oxygen-bridged dinuclear ruthenium amine complex, is a selective mitochondrial calcium uptake inhibitor. Ru360 potently inhibits Ca2+ uptake into mitochondria with an IC50 of 0.184 nM. Ru360 binds to mitochondria with high affinity (Kd of 0.34 nM). Ru360 has antiarrhythmic and cardioprotective effects[1][2]. Ru360 permeates slowly into the cell, and specifically inhibits mitochondrial calcium uptake in intact cardiomyocytes and in isolated heart. 1 μm Ru360 is taken up by myocardial ce... |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T8183 |
Deslanoside
洋地黄,去乙酰西地兰,Desacetyllanatoside C,Deacetyllanatoside C |
ATPase; Drug Metabolite | Membrane transporter/Ion channel; Metabolism |
Deslanoside (Desacetyllanatoside C) 是一种快速作用的强心苷,可抑制Na-K-ATPase 膜泵,导致细胞内钠和钙浓度增加。它用于研究充血性心力衰竭和因折返机制引起的室上性心律失常,并在研究慢性心房颤动时控制心室率。 | |||
T2S2215 |
Crebanine
|
Apoptosis; Others; Akt | Apoptosis; Cytoskeletal Signaling; Others; PI3K/Akt/mTOR signaling |
Crebanine 是来自于韦诺萨千金藤的一种生物碱,通过抑制 MAPKs 和 Akt 信号通路表现出抗炎活性,还具有抗心律失常的作用。它可诱导人类癌细胞的 G1阻滞和凋亡。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T10229 |
Acebutolol D7
|
Others | Others |
Acebutolol D7 is a deuterium-labeled Acebutolol. Acebutolol is a selective antagonist of the β1 adrenergic receptor used in the treatment of angina pectoris, hypertension, and cardiac arrhythmias. |