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Search Results for " airway smooth muscle "

Targets Recommended: HDAC PDE Adenosine Receptor

9

抑制剂 & 化合物

3

天然产物

4

重组蛋白

1

同位素标记化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T1083L	Theophylline monohydrate Quibron,茶碱一水合物	HDAC; PDE; Adenosine Receptor	Chromatin/Epigenetic; DNA Damage/DNA Repair; GPCR/G Protein; Metabolism; Neuroscience
	Theophylline monohydrate (Quibron) 似乎抑制磷酸二酯酶和前列腺素的产生，调节钙通量和细胞内钙分布，并拮抗腺苷。茶碱是黄嘌呤的天然生物碱衍生物，从植物山茶花和小粒咖啡中分离出来。在生理上，该药剂可放松支气管平滑肌，产生血管舒张（脑血管除外），刺激中枢神经系统，刺激心肌，利尿，增加胃酸分泌；它还可以抑制炎症并改善横膈膜的收缩性。
T16564	PPADS tetrasodium	P2X Receptor; Na+/Ca2+ Exchanger	Membrane transporter/Ion channel; Neuroscience
	PPADS tetrasodiuma 是一种有效的 P2X 受体拮抗剂，也是是豚鼠气道平滑肌 Na/Ca²⁺ 交换逆模式的抑制剂，对谷氨酸/NMDA毒性有神经保护作用。PPADS tetrasodiuma 抑制 P2X1、P2X-2、P2X-3 和 P2X-5。
T68129L1	Picumeterol FA Picumeterol FA(130641-36-0 Free base)	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	picumeterol FA 是一种有效的选择性β2肾上腺素能受体激动剂。在体外和体内试验中，picumeterol FA 可产生持久的气道平滑肌松弛作用。picumeterol FA 是一种纯 R 对映异构体，可用于改善哮喘患者的肺功能和降低气道高反应性。
T6707	Tiotropium Bromide hydrate BA-679 BR hydrate,BA 679BR,噻托溴铵一水合物	AChR	Neuroscience
	Tiotropium Bromide hydrate (BA-679 BR hydrate) 是长效的毒蕈碱受体拮抗剂，可用于治疗慢性阻塞性气道疾病 (COPD)。
T32156	Indimilast	Others	Others
	Indimilast is used to inhibit phosphodiesterase IV that regulates lung inflammation and causes bronchiectasis by increasing intracellular cyclic adenosine 3', 5'-monophosphate in airway smooth muscle and inflammatory cells. Potential to treat chronic obst
T68129	Picumeterol GR 114297A	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Picumeterol（GR 114297A）是一种有效的选择性β2肾上腺素能受体激动剂。在体外和体内试验中，Picumeterol 可产生持久的气道平滑肌松弛作用。Picumeterol 是一种纯 R 对映异构体，可用于改善哮喘患者的肺功能和降低气道高反应性。
T37228	(±)8(9)-EpETE	Others	Others
	Eicosapentaenoic acid is converted to epoxyeicosatetraenoic acids (EpETEs) by several cytochrome P450 isoforms. The major product of this epoxygenase pathway, (±)17(18)-EpETE , relaxes vascular and airway smooth muscle by activating large conductance Ca2+-activated K+ (BKCa) channels by directly interacting with BKα channel subunits. (±)8(9)-EpETE is an epoxygenase pathway product produced from EPA by CYP450 both in vitro and in vivo. The biological actions and physiological effects of this epox...
T60332	Methacholine bromide	Others	Others
	Methacholine (Acetyl-β-methylcholine) bromide 是一种有效的muscarinic-3 (M3)激动剂。Methacholine bromide 直接作用于平滑肌上的乙酰胆碱受体，导致支气管收缩和气道变窄。Methacholine bromide 对识别支气管高反应性 (BHR) 显示出高灵敏度，BHR 是哮喘的重要特征。Methacholine bromide 可用于测量气道高反应性 (AHR)，作为评估具有哮喘样症状和正常静息呼气流速的个体的诊断辅助[2]。
T60511	Theophylline sodium glycinate	Others	Others
	Theophylline (1,3-Dimethylxanthine) sodium glycinate 是一种有效的磷酸二酯酶 (PDE) 抑制剂，可抑制 PDE3 活性以松弛气道平滑肌。Theophylline sodium glycinate 可用于研究哮喘和慢性阻塞性肺疾病 (COPD) 。Theophylline sodium glycinate 也是一种腺苷受体拮抗剂和组蛋白脱乙酰酶 (HDAC) 激活剂。 Theophylline sodium glycinate 通过增加 IL-10 和抑制 NF-κB 的核输入而具有抗炎活性。Theophyllin sodium glycinate 可诱导细胞凋亡。

化合物

Theophylline monohydrate

Cat.No: T1083L

Synonym: Quibron,茶碱一水合物

Target: HDAC, PDE, Adenosine Receptor

PPADS tetrasodium

Cat.No: T16564

Target: P2X Receptor, Na+/Ca2+ Exchanger

Cat.No: T68129L1

Synonym: Picumeterol FA(130641-36-0 Free base)

Target: Adrenergic Receptor

Tiotropium Bromide hydrate

Cat.No: T6707

Synonym: BA-679 BR hydrate,BA 679BR,噻托溴铵一水合物

Target: AChR

Cat.No: T32156

Target: Others

Cat.No: T68129

Synonym: GR 114297A

Target: Adrenergic Receptor

Cat.No: T37228

Target: Others

Methacholine bromide

Cat.No: T60332

Target: Others

Theophylline sodium glycinate

Cat.No: T60511

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T1083	Theophylline Theo-24,1,3-Dimethylxanthine,茶碱	Endogenous Metabolite; HDAC; PDE; Adenosine Receptor; Autophagy	Autophagy; Chromatin/Epigenetic; DNA Damage/DNA Repair; GPCR/G Protein; Metabolism; Neuroscience
	Theophylline (1,3-Dimethylxanthine) 是茶中的甲基黄嘌呤衍生物，具有利尿、平滑肌松弛、支气管扩张、心脏和中枢神经系统兴奋作用。
T4S0998	Trifolirhizin 红车轴草根甙/三叶豆紫檀苷,三叶豆紫檀苷	TNF; Tyrosinase	Apoptosis; Proteases/Proteasome
	Trifolirhizin 是一种从苦参根中分离出的 pterocarpan 黄酮类化合物。它具有酪氨酸酶高抑制活性，IC50=506 μM。它具有抗炎和抗癌的潜能。
T41276	Peimisine hydrochloride
	Peimisine hydrochloride 非竞争性拮抗气管平滑肌 M 受体，抑制 Ach 引起的平滑肌收缩。它兴奋 β 受体和拮抗内钙释放，促进一氧化氮释放，可舒张气管平滑肌，有平喘作用。

天然产物

Cat.No: T1083

Synonym: Theo-24,1,3-Dimethylxanthine,茶碱

Target: Endogenous Metabolite, HDAC, PDE, Adenosine Receptor, Autophagy

Cat.No: T4S0998

Synonym: 红车轴草根甙/三叶豆紫檀苷,三叶豆紫檀苷

Target: TNF, Tyrosinase

Peimisine hydrochloride

Cat.No: T41276

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPJ-01210	IL-33 Protein, Mouse, Recombinant Interleukin-1 family member 11,白细胞介素,NF-HEV and IL- 1F11,白介素...	Mouse	E. coli
	Mouse Interleukin 33 (IL-33) is a 30 kDa proinflammatory cytokine which may also regulates gene transcription in producer cells. IL-33 is constitutively expressed in smooth muscle and airway epithelia. IL-33 was identified based on sequence and structural homology with IL-1 family cytokines. It is up‑regulated in arterial smooth muscle, dermal fibroblasts, and keratinocytes following IL-1 alpha or IL‑1 beta stimulation. IL-33 is structurally related to IL-1, which induces helper T cells to produ...
TMPH-02540	GRK2 Protein, Mouse, Recombinant (His & SUMO) Beta-adrenergic receptor kinase 1,Grk2,G-protein-coupled rec...	Mouse	E. coli
	Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them. Key regulator of LPAR1 signaling. Competes with RALA for binding to LPAR1 thus affecting the signaling properties of the receptor. Desensitizes LPAR1 and LPAR2 in a phosphorylation-independent manner. Positively regulates ciliary smoothened (SMO)-dependent Hedgehog (Hh) signaling pathway by facilitating the trafficking of SMO into the cilium and...
TMPH-03753	MYLK Protein, Human, Recombinant (His) MYLK,Myosin light chain kinase, smooth muscle	Human	E. coli
	Calcium/calmodulin-dependent myosin light chain kinase implicated in smooth muscle contraction via phosphorylation of myosin light chains (MLC). Also regulates actin-myosin interaction through a non-kinase activity. Phosphorylates PTK2B/PYK2 and myosin light-chains. Involved in the inflammatory response (e.g. apoptosis, vascular permeability, leukocyte diapedesis), cell motility and morphology, airway hyperreactivity and other activities relevant to asthma. Required for tonic airway smooth muscl...
TMPH-02526	Arginase-2/ARG2 Protein, Mouse, Recombinant (His & SUMO) Arginase II,Kidney-type arginase,Type II arginase,Arg2,Argin...	Mouse	E. coli
	May play a role in the regulation of extra-urea cycle arginine metabolism and also in down-regulation of nitric oxide synthesis. Extrahepatic arginase functions to regulate L-arginine bioavailability to nitric oxid synthase (NOS). Arginine metabolism is a critical regulator of innate and adaptive immune responses. Seems to be involved in negative regulation of the survival capacity of activated CD4(+) and CD8(+) T cells. May suppress inflammation-related signaling in asthmatic airway epithelium....

重组蛋白

IL-33 Protein, Mouse, Recombinant

Cat.No: TMPJ-01210

Species: Mouse

Expression System: E. coli

GRK2 Protein, Mouse, Recombinant (His & SUMO)

Cat.No: TMPH-02540

Species: Mouse

Expression System: E. coli

MYLK Protein, Human, Recombinant (His)

Cat.No: TMPH-03753

Species: Human

Expression System: E. coli

Arginase-2/ARG2 Protein, Mouse, Recombinant (His & SUMO)

Cat.No: TMPH-02526

Species: Mouse

Expression System: E. coli

Cat. No.	Product Name	Target	Signaling Pathways
T11240	Ethacrynic acid D5	Others	Others
	Ethacrynic acid, a diuretic, functions as an inhibitor of L-type voltage-dependent and store-operated calcium channels, facilitating the relaxation of airway smooth muscle (ASM) cells. It exhibits anti-inflammatory effects, notably reducing retinoid-induced ear edema in mice, and inhibits glutathione S-transferases (GSTs), making it a potent suppressor of the NF-kB signaling pathway. Additionally, ethacrynic acid modulates leukotriene formation. A variant, Ethacrynic acid D5, is distinguished by...

同位素标记化合物

Ethacrynic acid D5

Cat.No: T11240

Target: Others

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