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Search Results for " dna ligase "

Targets Recommended: DNA DNA/RNA Synthesis

16

抑制剂 & 化合物

1

天然产物

9

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T4517	L189	DNA; DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	L189 是一种人类 DNA 连接酶抑制剂，抑制 hLigI/III/IV，IC50值分别为5、9 和 5 μM。
T3103	L67 DNA Ligase Inhibitor	DNA; DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	L67 (DNA Ligase Inhibitor) 是一种竞争性人类 DNA 连接酶抑制剂，抑制 DNA 连接酶 I 和 III，IC50为10μM。
T1724	SCR7 pyrazine SCR7,SCR7 吡嗪	Apoptosis; DNA/RNA Synthesis; CRISPR/Cas9	Apoptosis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	SCR7 pyrazine (SCR7) 是一种 DNA 连接酶 IV 抑制剂，以连接酶 IV 依赖的方式阻断非同源末端连接。它也是 CRISPR/Cas9的增强子，可提高 Cas9 介导的同源性定向修复的效率。它诱导细胞凋亡，具有抗癌活性。
T9150	SCR130 1,7,9-Triazaspiro[4.5]dec-1-ene-6,10-dione, 2,4-bis(4-chlorophenyl)-8-thioxo-	Apoptosis; Others; DNA/RNA Synthesis	Apoptosis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Others
	SCR130 (1,7,9-Triazaspiro[4.5]dec-1-ene-6,10-dione, 2,4-bis(4-chlorophenyl)-8-thioxo-) 是基于 SCR7 的 DNA 非同源末端连接抑制剂，可诱导细胞凋亡并，具有抗癌活性。它特异性依赖连接酶 IV，抑制 DNA 的末端连接。
T6611	NSC697923 2-[(4-methylphenyl)sulfonyl]-5-nitrofuran	E1/E2/E3 Enzyme	Ubiquitination
	NSC-697923 (2-[(4-methylphenyl)sulfonyl]-5-nitrofuran), a potent inhibitor of UBE2N (ubiquitin-conjugating enzyme E2 N, Ubc13), exhibits its role in inducing cell death in neuroblastoma (NB) cells through two distinct mechanisms. In p53 wild-type NB cells, NSC-697923 promotes the nuclear importation of p53, thereby triggering cell death. Meanwhile, in p53 mutant NB cells, NSC-697923 activates the JNK-mediated apoptotic pathway, leading to cell death. Additionally, NSC-697923 inhibits DNA damage ...
T3340	SCR7	Apoptosis; DNA/RNA Synthesis; CRISPR/Cas9	Apoptosis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	SCR7 是一种特异性 DNA 连接酶 IV 抑制剂，可阻断非同源末端连接。它是一种不稳定的形式，可以自动循环成稳定形式的 SCR7 pyrazine。它也是CRISPR/Cas9的增强子，可提高 Cas9 介导的同源性定向修复的效率。它诱导细胞凋亡并具有抗癌活性。
T60753	L82	DNA	DNA Damage/DNA Repair
	L82 是一种 DNA 连接酶 1 (DNA Lig1) 抑制剂 (hLig1 IC50=12 μM)，具有选择性和非竞争性。L82 对乳腺癌细胞表达出抗增殖活性。
T25817	Mitonafide NSC-300288,米托萘胺,NSC300288,NSC 300288	Antibacterial	Microbiology/Virology
	Mitonafide (NSC-300288) 抑制 M. tuberculosis NAD+ 依赖性 DNA 连接酶 A 的活性。它是一种 DNA 嵌入剂。
T6610	XI-006 NSC 207895,可可碱	Mdm2; p53	Apoptosis
	XI-006 (XI-006) 是一种DNA 破坏剂、抗肿瘤剂和p53的激活剂。
T36733	HLI373 dihydrochloride	Others	Others
	HLI373 dihydrochloride is a potent Hdm2 inhibitor, efficiently restraining the ubiquitin ligase activity of Hdm2 and effectively prompting apoptosis in DNA-damaging agent-sensitive tumor cells[1]. Additionally, HLI373 dihydrochloride exhibits antimalarial activity[2].
T79924	T4 RNA ligase	DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	T4 RNA ligase为一RNA连接酶，催化单链DNA分子的连接作用。该酶在酶促低核糖核苷酸合成及RNA 3'端标记过程中应用。
T78166	MEL24	Others	Others
	MEL24为Mdm2 E3连接酶抑制剂，通过p53依赖机制降低细胞存活率，增强对DNA损伤剂的敏感性，适用于体外抗肿瘤研究。
T75343	JOE	Others	Others
	JOE，作为一种荧光染料，主要应用于 DNA 测序、PCR 以及 LCR 扩增。其吸光度和发射波长分别为 525 nm 和 550 nm。
T22087	HLI 373	Others	Others
	HLI373 是一种有效的 Hdm2抑制剂, Hdm2 是一种泛素连接酶(E3)。HLI373 可有效诱导肿瘤细胞 (对 DNA 破坏剂敏感的) 凋亡 (apoptosis)，并且具有抗疟疾 (antimalarial) 活性。
T69117	Pinafide	Others	Others
	Pinafide is a rodenticide and anti-protozoal agent. Pinafide shows strong cytostatic activity against both HeLa and KB cells and is moderately toxic to both mice and rats. It has been proved active against experimental tumors and shown to be inhibitor of two DNA viruses. Pinafide blocks cell growth by inhibiting DNA and RNA synthesis. It has been shown to bind to double-helical DNA by intercalation. Pinafide inhibited the activity of M. tuberculosis NAD⁺-dependent DNA ligase A at concentrations ...
T74410	PROTAC AR-V7 degrader-1	PROTACs	PROTAC
	PROTACAR-V7 degrader-1 (Compound 6)为一种口服有效的，选择性针对AR-V7的降解剂，DC50值为0.32 µM，其作用机制主要是通过VHL E3连接酶将其招募至雄激素受体DNA结合域(AR DBD)。此外，PROTACAR-V7 degrader-1在表达AR-V7的22Rv1细胞系中展现出了活性，EC50值为0.88 µM。

化合物

Cat.No: T4517

Target: DNA, DNA/RNA Synthesis

Cat.No: T3103

Synonym: DNA Ligase Inhibitor

Target: DNA, DNA/RNA Synthesis

Cat.No: T1724

Synonym: SCR7,SCR7 吡嗪

Target: Apoptosis, DNA/RNA Synthesis, CRISPR/Cas9

Cat.No: T9150

Synonym: 1,7,9-Triazaspiro[4.5]dec-1-ene-6,10-dione, 2,4-bis(4-chlorophenyl)-8-thioxo-

Target: Apoptosis, Others, DNA/RNA Synthesis

Cat.No: T6611

Synonym: 2-[(4-methylphenyl)sulfonyl]-5-nitrofuran

Target: E1/E2/E3 Enzyme

Cat.No: T3340

Target: Apoptosis, DNA/RNA Synthesis, CRISPR/Cas9

Cat.No: T60753

Target: DNA

Cat.No: T25817

Synonym: NSC-300288,米托萘胺,NSC300288,NSC 300288

Target: Antibacterial

Cat.No: T6610

Synonym: NSC 207895,可可碱

Target: Mdm2, p53

HLI373 dihydrochloride

Cat.No: T36733

Target: Others

T4 RNA ligase

Cat.No: T79924

Target: DNA/RNA Synthesis

Cat.No: T78166

Target: Others

Cat.No: T75343

Target: Others

Cat.No: T22087

Target: Others

Cat.No: T69117

Target: Others

PROTAC AR-V7 degrader-1

Cat.No: T74410

Target: PROTACs

Cat. No.	Product Name	Target	Signaling Pathways
T6407	β-Lapachone 3,4-二氢-2,2-二甲基-2H-萘并[1,2-B]吡喃-5,6-二酮,Beta-Lapachone,NSC-26326,SL-11001,ARQ-501	IDO; Apoptosis; Topoisomerase; Autophagy	Apoptosis; Autophagy; DNA Damage/DNA Repair; Metabolism
	β-Lapachone (ARQ-501) 是一种萘醌类天然产物，是拓扑异构酶 I 抑制剂，通过抑制细胞周期进程来诱导细胞凋亡。

天然产物

Cat.No: T6407

Synonym: 3,4-二氢-2,2-二甲基-2H-萘并[1,2-B]吡喃-5,6-二酮,Beta-Lapachone,NSC-26326,SL-11001,ARQ-501

Target: IDO, Apoptosis, Topoisomerase, Autophagy

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPH-00475	DNA ligase Protein, Desulfotalea psychrophila, Recombinant (His) Polydeoxyribonucleotide synthase [NAD(+)],ligA,DNA ...	Desulfotalea psychrophila	E. coli
	DNA ligase Protein, Desulfotalea psychrophila, Recombinant (His) is expressed in E. coli.
TMPH-00425	DNA ligase Protein, Colwellia psychrerythraea, Recombinant (His) ligA,DNA ligase,Polydeoxyribonucleotide sy...	Colwellia psychrerythraea	E. coli
	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA. DNA ligase Protein, Colwellia psychrerythraea, Recombinant (His) is expressed in E. coli expression system with N-10xHis tag. The predicted molecular weight is 42.1 kDa and the accession number is Q47YI0.
TMPY-02521	HIST3H2A Protein, Human, Recombinant histone cluster 3, H2a,MGC3165	Human	E. coli
	Histones are a complex family of highly conserved basic proteins responsible for packaging chromosomal DNA into nucleosomes. There are subtype diversities: H1, H2A, H2B, and H3 or H4. It has become more and more evident that histone modifications are key players in the regulation of chromatin states and dynamics as well as in gene expression. Therefore, histone modifications and the enzymatic machinery that set them are crucial regulators that can control cellular proliferation, differentiation,...
TMPH-00732	RtcB Protein, E. coli, Recombinant (His) rtcB,3'-phosphate/5'-hydroxy nucleic acid ligase,RN...	E. coli	P. pastoris (Yeast)
	GTP-dependent RNA ligase that is involved in tRNA splicing and RNA repair. Joins RNA with 2',3'-cyclic-phosphate or 3'-phosphate ends to RNA with 5'-hydroxy ends. Also acts as a DNA ligase in case of DNA damage by splicing 'dirty' DNA breaks, characterized by 3'-phosphate (or cyclic-phosphate) and 5'-hydroxy ends that cannot be sealed by classical DNA ligases.
TMPH-01273	TRIP12 Protein, Human, Recombinant (His & Myc) Thyroid receptor-interacting protein 12,E3 ubiquitin-protein...	Human	E. coli
	E3 ubiquitin-protein ligase involved in ubiquitin fusion degradation (UFD) pathway and regulation of DNA repair. Part of the ubiquitin fusion degradation (UFD) pathway, a process that mediates ubiquitination of protein at their N-terminus, regardless of the presence of lysine residues in target proteins. Acts as a key regulator of DNA damage response by acting as a suppressor of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of 'Lys-63'-linked histone H2A and H2AX at DNA damag...
TMPH-01270	TRAIP Protein, Human, Recombinant (His) E3 ubiquitin-protein ligase TRAIP,TRAF-interacting ...	Human	E. coli
	E3 ubiquitin ligase required to protect genome stability in response to replication stress. Acts as a key regulator of interstrand cross-link repair, which takes place when both strands of duplex DNA are covalently tethered together, thereby blocking replication and transcription. Controls the choice between the two pathways of replication-coupled interstrand-cross-link repair by mediating ubiquitination of MCM7 subunit of the CMG helicase complex. Short ubiquitin chains on MCM7 promote recruitm...
TMPY-02228	p53 Protein, Cynomolgus, Recombinant tumor protein p53,p53,TP53	Cynomolgus	E. coli
	p53, also known as Tp53, is a DNA-binding protein which belongs to the p53 family. It contains transcription activation, DNA-binding, and oligomerization domains. p53 protein is expressed at low level in normal cells and at a high level in a variety of transformed cell lines, where it's believed to contribute to transformation and malignancy. p53 (TP53) is a transcription factor whose protein levels and post-translational modification state alter in response to cellular stress (such as DNA damag...
TMPJ-00486	SUMO2 Protein, Human, Recombinant (His) HSMT3,Ubiquitin-Like Protein SMT3A,SUMO-3,SMT3A,Sentrin-2,SM...	Human	E. coli
	Small Ubiquitin-Related Modifier 2 (SUMO2) is an Ubiquitin-like protein that belongs to the ubiquitin family with SUMO subfamily. It is a family of small, related proteins that can be enzymatically attached to a target protein by a post-translational modification process termed sumoylation. SUMO2 can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptidebond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and l...
TMPH-01267	RNF13 Protein, Human, Recombinant (His & Myc) RING finger protein 8,RNF8,E3 ubiquitin-protein ligase	Human	E. coli
	E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of hist...

重组蛋白

DNA ligase Protein, Desulfotalea psychrophila, Recombinant (His)

Cat.No: TMPH-00475

Species: Desulfotalea psychrophila

Expression System: E. coli

DNA ligase Protein, Colwellia psychrerythraea, Recombinant (His)

Cat.No: TMPH-00425

Species: Colwellia psychrerythraea

Expression System: E. coli

HIST3H2A Protein, Human, Recombinant

Cat.No: TMPY-02521

Species: Human

Expression System: E. coli

RtcB Protein, E. coli, Recombinant (His)

Cat.No: TMPH-00732

Species: E. coli

Expression System: P. pastoris (Yeast)

TRIP12 Protein, Human, Recombinant (His & Myc)

Cat.No: TMPH-01273

Species: Human

Expression System: E. coli

TRAIP Protein, Human, Recombinant (His)

Cat.No: TMPH-01270

Species: Human

Expression System: E. coli

p53 Protein, Cynomolgus, Recombinant

Cat.No: TMPY-02228

Species: Cynomolgus

Expression System: E. coli

SUMO2 Protein, Human, Recombinant (His)

Cat.No: TMPJ-00486

Species: Human

Expression System: E. coli

RNF13 Protein, Human, Recombinant (His & Myc)

Cat.No: TMPH-01267

Species: Human

Expression System: E. coli

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