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Cat. No. | Product Name | ||
---|---|---|---|
L2570 | 人代谢物化合物库 | 4454 compounds | |
4454 种人代谢物的独特集合,用于高通量、高内涵筛选; |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T26080 |
Ribocitrin
Citric acid tririboside,Triribofuranosylcitrate |
Others | Others |
Ribocitrin is a dextransucrase inhibitor. | |||
T75312 |
Citric acid triammonium
|
Others | Others |
Citric acid triammonium (Triammonium citrate) 由柠檬酸 Citric acid 与氨按 1:3 摩尔比反应而成。 Citric acid triammonium 可以作为碳源制备碳量子点 (CDs)。高氮组分的 Citric acid triammonium 可能促进 CDs 中氮基官能团的形成,从而提高 CDs 的发射色可调性。 | |||
T8841 |
IMT1
Propanamide, N,N-dimethyl-2-[[4-(2-methylphenyl)-2-oxo-2H-1-benzopyran-7-yl]oxy]-,LDC195943(IMT1) |
Others; DNA/RNA Synthesis; Mitochondrial Metabolism | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism; Others |
IMT1 (Propanamide, N,N-dimethyl-2-[[4-(2-methylphenyl)-2-oxo-2H-1-benzopyran-7-yl]oxy]-) 是一种非竞争特异性人类线粒体 RNA 聚合酶(POLRMT) 抑制剂,可引起 POLRMT 的构象变化,以剂量依赖性方式阻断底物结合和转录。它可降低脱氧核苷三磷酸水平和柠檬酸循环中间体,导致细胞氨基酸水平显著消耗,有用于线粒体转录等相关疾病的研究潜力。 | |||
T65232 |
HEDTA
N-(2-Hydroxyethyl)ethylenediaminetriacetic acid |
Others | Others |
HEDTA 是一种螯合剂,常与柠檬酸联合用药来研究血液疾病和脑部血液应激。 | |||
T64394 |
GW 833972A
|
Cannabinoid Receptor | GPCR/G Protein |
GW 833972A 是一种选择性的 CB2 受体激动剂。GW 833972A 对诱导神经去极化具有抑制作用,且在动物模型中对柠檬酸引起的咳嗽具有抑制作用。 | |||
T64923 |
Sodium citrate
Citrosodine,Natrocitral,柠檬酸钠 |
Others | Others |
Sodium citrate (Natrocitral) 是柠檬酸的钠盐。Sodium citrate 诱导G2/M 期和S 期细胞凋亡和细胞周期阻滞。Sodium citrate 通过降低抗氧化酶活性引起肝脏氧化损伤。 | |||
T68904 |
GW-833972A free base
|
Others | Others |
GW833972 is a CB2 Agonist. GW 833972A inhibited capsaicin-induced depolarization of the human and guinea-pig and prostaglandin E(2) (PGE(2)) and hypertonic saline-induced depolarization of the guinea-pig isolated vagus nerve in vitro. GW 833972A also inhibited citric acid-induced cough but not plasma extravasation in the guinea-pig and this effect was blocked by a CB(2) receptor antagonist. | |||
T35628 |
AN-7
|
Others | Others |
α-Lipoic acid is a cyclic disulfide antioxidant that interconverts with its reduced dithiol form. It is an essential cofactor for decarboxylation reactions of the citric acid cycle and acts as a general antioxidant. AN-7 is a more lipophilic analog of α-lipoic acid with enhanced potency and 1.5-fold increased maximal capacity to stimulate glucose transport into myocytes. This identifies the analogs of lipoic acid as potential new treatments for diabetes. | |||
T76174 |
Isocitrate dehydrogenase
|
||
Isocitrate dehydrogenase(ICDH) 异柠檬酸脱氢酶是一种柠檬酸或三羧酸循环酶,常用于生化研究。Isocitrate dehydrogenase 催化异柠檬酸氧化脱羧生成 α-酮戊二酸,并将 NAD(P)+还原为 NAD(P)H,在细胞代谢中起重要作用。 | |||
T37323 |
Succinyl-Coenzyme A sodium salt
Succinyl-CoA sodium salt,Succinyl-Coenzyme A (sodium salt),Succinyl-CoA |
Endogenous Metabolite | Metabolism |
Succinyl-Coenzyme A sodium salt(Succinyl-CoA sodium salt) 参与柠檬酸循环,在柠檬酸循环中转化为琥珀酸。Succinyl-Coenzyme A (sodium salt) 在生物体内参与多种代谢反应,在体内有着举足轻重的作用 Succinyl-Coenzyme A sodium salt 参与血红素的合成,可用于研究由营养性维生素 B12 缺乏症 (致使 Succinyl-Coenzyme A 合成缺乏) 所引起的代谢疾病、神经疾病和血液学异常导致的疾病。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T5S0636 |
Citric acid
柠檬酸,Citro,Citretten |
Apoptosis; Others; Endogenous Metabolite; Antibacterial; Antibiotic | Apoptosis; Metabolism; Microbiology/Virology; Others |
Citric acid (Citro) 是柑橘类水果中发现的弱有机三羧酸。柠檬酸是食品添加剂和天然防腐剂。 | |||
T5669 |
Citric acid monohydrate
|
Others | Others |
Citric acid monohydrate 是一种存在于柑橘类水果中的三羧酸。柠檬酸因其抗氧化特性而被用作药物制剂中的赋形剂。它保持活性成分的稳定性并用作防腐剂。 | |||
T0256 |
Citric acid trilithium salt tetrahydrate
Lithium citrate tribasic tetrahydrate,柠檬酸三锂盐四水合物,Trilithium citrate tetrahydrate |
Dehydrogenase; GSK-3; HIF/HIF Prolyl-Hydroxylase; Antibacterial; GluR | Chromatin/Epigenetic; Metabolism; Microbiology/Virology; Neuroscience; PI3K/Akt/mTOR signaling; Stem Cells |
Citric acid trilithium salt tetrahydrate (Lithium citrate tribasic tetrahydrate) 是一种用于治疗精神疾病的药物。它也是一种医药和建筑材料, 可用于氨基酸定量分析时的梯度洗脱。 | |||
T12952 |
Sodium citrate dihydrate
Citric acid trisodium salt dihydrate,Trisodium citrate dihydrate,二水合柠檬酸钠 |
Antibacterial | Microbiology/Virology |
Sodium citrate dihydrate (Trisodium citrate dihydrate) 是一种抗凝血剂,也用为缓冲剂和食品防腐剂。 | |||
T10857 |
Coenzyme A
|
Endogenous Metabolite | Metabolism |
Coenzyme A 是所有活细胞中必需的辅助因子,由泛酸,三磷酸腺苷和半胱氨酸合成的。Coenzyme A 与过氧化物酶 5 共价结合导致其过氧化物酶活性完全抑制,通过 DTT 还原能够逆转。Coenzyme A 及其硫酯衍生物是主要分解代谢,合成代谢途径和基因表达调控的关键参与者。 | |||
T5087 |
DL-Isocitric acid trisodium salt
异柠檬酸三钠盐,Isocitric acid trisodium salt |
Others; Endogenous Metabolite | Metabolism; Others |
DL-Isocitric acid trisodium salt 是内源性代谢产物的一种。 | |||
T64824 |
Dimethyl Citric acid
|
Others | Others |
Dimethyl Citric acid 是一种天然产物,可用于生命科学领域的相关研究,其产品编号为 T64824。 | |||
T8137 |
(Z)-Aconitic acid
顺乌头酸,顺式乌头酸,Cls-Aconitic acid |
Others; Endogenous Metabolite | Metabolism; Others |
(Z)-Aconitic acid 是 Aconitic acid 的顺式异构体。它是三羧酸循环中柠檬酸盐异构化为异柠檬酸盐的中间产物。 | |||
T7989 |
Trimethyl phosphate
|
Others | Others |
Trimethyl phosphate 是一种有机磷化合物,是催化磷酸化化合物水解的酶的抑制剂,已被用作合成肽和其他蛋白质的反应物,用作合成有机和无机化合物的催化剂,以及用作合成药物的试剂。 | |||
T20113 |
D-(+)-Malic acid
(R)-Malic acid,Malic acid, D-,D-(+)-苹果酸,D-Malic acid |
Others | Others |
D-(+)-Malic acid ((R)-Malic acid) 一种是Malic acid 活性异构体,是竞争性的 L(--)malic acid 转运的抑制剂。 | |||
T4862 |
Oxaloacetic acid
|
Endogenous Metabolite | Metabolism |
Oxaloacetic acid 是一种代谢中间体,涉及多种途径,如葡萄糖异生、柠檬酸循环、乙醛酸循环、尿素循环、氨基酸合成和脂肪酸合成。 | |||
T5260 |
2-Methylpentanedioic acid
2-甲基戊二酸,2-Methylglutaric acid,alpha-Methylglutarate |
Others; Endogenous Metabolite | Metabolism; Others |
2-Methylpentanedioic acid (alpha-Methylglutarate) 是一种琥珀酸的代谢产物,它通常存在于人体尿液、健康成人和儿童中。其中琥珀酸是一种柠檬酸循环中间体。 | |||
T5283 |
NADH disodium salt
Disodium NADH,NADH, disodium salt hydrate,beta-烟酰胺腺嘌呤二核苷二钠 |
Others; Endogenous Metabolite | Metabolism; Others |
NADH disodium salt hydrate是氧化还原酶的辅酶。 NADH在分解代谢过程中起到再生电子供体的作用,包括糖酵解,柠檬酸循环和β-氧化。 | |||
T2O2731 |
L-Aspartic acid
L-天冬氨酸,L-天冬氨酸;L-天冬碱;L-酰胺天冬酸;L-天冬酰胺一水物,Aspatofort,Asparagic acid |
Others; Endogenous Metabolite | Metabolism; Others |
L-Aspartic acid (Aspatofort) 是一种氨基酸,是结肠特异性药物输送的前体药物。 | |||
T5060 |
2-Oxobutanoic acid
2-酮丁酸,alpha-Ketobutyric Acid,2-Oxobutyric acid,Propionylformic acid |
Others; Endogenous Metabolite | Metabolism; Others |
2-Oxobutanoic acid (alpha-Ketobutyric Acid) 是一种胱硫醚的酶促裂解产物。它也是苏氨酸的降解产物之一。 它能够转化为丙酰辅酶A,从而进入柠檬酸循环。 | |||
T11589 |
Hydroxycitric acid tripotassium hydrate
柠檬酸钾一水合物,三水合钾柠檬酸,Potassium citrate monohydrate |
ATP Citrate Lyase; HIF/HIF Prolyl-Hydroxylase; HIF | Angiogenesis; Chromatin/Epigenetic; Metabolism |
Hydroxycitric acid tripotassium hydrate (Potassium citrate monohydrate) 是一种藤黄果的主要活性成分,也是一种柠檬酸的衍生物。它可竞争性抑制柠檬酸裂解酶 (ATP citrate lyase) ,并具有减肥作用。它有效抑制结石形成,并抑制HIF,具有抗氧化,抗炎和抗肿瘤活性。 | |||
T4838 |
(S)-Malic acid
L-(-)-Malic acid,(S)-(-)-HYDROXYSUCCINIC ACID,(S)-2-Hydroxysuccinic acid,L-苹果酸 |
Others; Endogenous Metabolite | Metabolism; Others |
(S)-Malic acid ((S)-2-Hydroxysuccinic acid) 是天然存在的二羧酸,是水果酸甜味的来源,常用作食品添加剂。 | |||
T1609 |
NAD+
烟酰胺腺嘌呤二核苷酸,Cozymase,煙酸胺,β-DPN,DPN,β-Nicotinamide Adenine Dinucleotide,β-NAD |
NADPH; Endogenous Metabolite | Metabolism |
NAD+ (β-Nicotinamide Adenine Dinucleotide) 是一种转递氢离子的辅酶,参与细胞中的氧化还原反应。NAD+ 参与糖酵解、柠檬酸循环、脂肪酸氧化等。NAD+ 接受来自其他分子的电子形成 NADH,然后又作为还原剂来给电子。 | |||
TN4540 | Methyl demethoxycarbonylchanofruticosinate | Others | Others |
Methyl demethoxycarbonylchanofruticosinate exhibits significant antitussive activity in a citric acid induced guinea pig cough model. | |||
T4S0083 |
Protostemonine
|
Others | Others |
Protostemonine 是一种主要从 Stemona sesslifolia 根中分离得到的生物碱,对哮喘及革兰氏阴性菌所致急性肺损伤有抗炎作用。 |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPJ-00955 |
MDH1 Protein, Human, Recombinant (His)
Cytosolic Malate Dehydrogenase,MDH1,MDHA,Diiodophenylpyruvat... |
Human | E. coli |
Malate Dehydrogenase, Cytoplasmic (MDH1) is an enzyme which belongs to the MDH Type 2 sub-family of LDH/MDH superfamily. MDH1 is involved in the Citric Acid Cycle that catalyzes the conversion of Malate into Oxaloacetate (using NAD+) and vice versa. MDH1 should not be confused with Malic Enzyme, which catalyzes the conversion of Malate to Pyruvate, producing NADPH. MDH1 also participates in Gluconeogenesis, the synthesis of Glucose from smaller molecules. Pyruvate in the mitochondria is acted up... | |||
TMPY-02375 |
acnB Protein, E. coli, Recombinant
yacI,yacJ |
E. coli | E. coli |
Escherichia coli contains two major aconitases (Acns), AcnA and AcnB. They are distantly related monomeric Fe-S proteins that contain different arrangements of four structural domains. acnA is specifically subject to SoxRS-mediated activation, whereas acnB encodes the major aconitase that is synthesized earlier in the growth cycle than AcnA. It is concluded that AcnB is the major citric acid cycle enzyme. Aconitate hydratase 2 (acnB) catalyzes the isomerization of citrate to isocitrate via cis-a... | |||
TMPJ-00956 |
MDH2 Protein, Human, Recombinant (His)
MDH2,Malate dehydrogenase,mitochondrial |
Human | HEK293 Cells |
Malate dehydrogenase, mitochondrial is a 338 amino acids protein that belongs to the LDH/MDH superfamily. MDH type 1 family. MDH2 catalyzes the reversible oxidation of malate to oxaloacetate, utilizing the NAD/NADH cofactor system in the citric acid cycle. MDH2 is localized to the mitochondria and takes part in the malate-aspartate shuttle that functions in the metabolic coordination between cytosol and mitochondria. MDH2 is highly expressed in the adrenal system, small intestine, heart and panc... | |||
TMPH-02150 |
SUCLG2 Protein, Human, Recombinant (His & SUMO)
Succinate--CoA ligase [GDP-forming] subunit beta, mitochondr... |
Human | E. coli |
GTP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. SUCLG2 Protein, Human, Recombinant (His & SUMO) is expressed in E. coli expression system wit... | |||
TMPY-02288 |
Glyoxalase II/HAGH Protein, Human, Recombinant (His)
HAGH1,GLO2,GLX2,hydroxyacylglutathione hydrolase,GLXII |
Human | E. coli |
HAGH (Hydroxyacylglutathione Hydrolase) is a Protein Coding gene. 3 alternative splicing and alternative initiation of human isoforms have been reported. The enzyme encoded by this gene is classified as a thioesterase and is responsible for the hydrolysis of S-lactoyl-glutathione to reduced glutathione and D-lactate. HAGH belongs to the Metallo-beta-lactamase superfamily. HAGH is widely expressed in the kidney, liver, and other tissues. Diseases associated with HAGH include Hydroxyacyl Glutathio... |