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肿瘤坏死因子受体 (Tumor Necrosis Factor Receptors, TNFRs)

肿瘤坏死因子受体 (Tumor Necrosis Factor Receptor, TNFR) 超家族(TNFRSF)是细胞因子受体的蛋白质超家族,其特征在于能够通过富含细胞外半胱氨酸的结构域结合肿瘤坏死因子 (TNFs)。TNFRs主要参与细胞凋亡和炎症,但它们也可以参与其他信号转导途径,如增殖、存活和分化。TNFRs在哺乳动物的多种组织中表达,特别是在白细胞中。TNFRSF有 27 个家族成员,从严格意义上讲, TNFR通常指TNFR1和TNFR2。

  • 4-1BB/CD137/TNFRSF9 Protein, Mouse, Recombinant (hFc)
    TMPJ-00145
    Tumor necrosis factor receptor superfamily member 9(TNFRSF9) is a member of the tumor necrosis factor (TNF) receptor family. It can be induced by lymphocyte activation (ILA) and is expressed by activated T cells, but to a larger extent on CD8 than on CD4 T cells. In addition, TNFRSF9 expression is found on dendritic cells, follicular dendritic cells, natural killer cells, granulocytes and cells of blood vessel walls at sites of inflammation. As receptor for TNFSF9 4-1BBL, it can activate T cells and the cross-linking of this protein can enhance T cell proliferation, IL-2 secretion survival and cytolytic activity. Further, it can enhance immune activity to eliminate tumors in mice.
    • ¥ 700
    5日内发货
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  • RANK/TNFRSF11A Protein, Mouse, Recombinant (His)
    TMPJ-00674
    Receptor activator of NF-κB(RANK,TNFRSF11A) belongs to one member of tumor necrosis factor receptor family.It is a receptor for TNFSF11 RANKL TRANCE OPGL. This gene encodes a type 1 membrane protein with a 30 amino acids (aa) signal peptide, 184 aa extracellular region , a 20 aa transmembrane domain and a 391 aa cytoplasmic region. Human and murine RANK share 81% aa identity in their extracellular domains. RANK is ubiquitous highly expressed in trabecular bone, thymus, small intestine, lung, brain and kidney, but weakly expressed in spleen and bone marrow. After binding its ligand RANKL, RANK can activate signaling pathways such as NF-κB, JNK, ERK, p38, and Akt PKB, through TRAF protein phosphorylation. RANK TNFRSF11A signaling is largely considered to be growth promoting and apoptosis reducing such as the effects observed in osteoclasts. RANK TNFRSF11A was also found to be involved in the regulation of interactions between T-cells and dendritic cells.
    • ¥ 740
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  • GITR/TNFRSF18 Protein, Mouse, Recombinant (hFc & His)
    TMPJ-00110
    Tumor necrosis factor receptor superfamily member 18(Gitr) contains 3 TNFR-Cys repeats and it have four isforms.IsformA、isformB and isformC is single-pass type I membrane protein and isformD is a secreted protein. The protein is the receptor for TNFSF18.It seems to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. It mediated NF-kappa-B activation via the TRAF2 NIK pathway.It binds to TRAF1, TRAF2, and TRAF3, but not TRAF5 and TRAF6 and binds through its C-terminus to SIVA1 SIVA.It preferentially expressed in activated T lymphocytes and up-regulated in peripherical mononuclear cells after antigen stimulation lymphocyte activation.
    • ¥ 700
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  • TRAIL R3/TNFRSF10C Protein, Human, Recombinant (hFc & His)
    TMPJ-00418
    Tumor Necrosis Factor Receptor Superfamily Member 10C (TNFRSF10C) is a glycosyl-phosphatidylinositol-linked membrane protein which binds TRAIL with high affinity. TNFRSF10C has the TRAIL-binding extracellular cysteine-rich domains, lacks the intracellular signaling domain. As a result, binding of TRAIL to TRAIL R3 doesn’t transduce an apoptosis signal. The expression of TRAIL R3 gene has been shown to protect cells bearing TRAIL R1 and or TRAIL R2 from TRAIL-induced apoptosis.
    • ¥ 380
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  • TNF RII Protein, Human, Recombinant (hFc)
    TMPJ-00287
    TNF RII Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-Fc tag. The predicted molecular weight is 60-90 KDa and the accession number is P20333.
    • ¥ 740
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  • CD30/TNFRSF8 Protein, Human, Recombinant (mFc)
    TMPJ-00343
    CD30 TNFRSF8 Protein, Human, Recombinant (mFc) is expressed in HEK293 mammalian cells with C-mFc tag. The predicted molecular weight is 90-120 KDa and the accession number is P28908.
    • ¥ 370
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  • CD40 Protein, Cynomolgus, Recombinant (His)
    TMPJ-00634
    CD40 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 28-30 KDa and the accession number is G7PG38.
    • ¥ 740
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  • TRAIL R1/DR4/TNFRSF10A Protein, Human, Recombinant (His)
    TMPJ-00655
    Tumor necrosis factor receptor superfamily member 10A (TNFRSF10A) is also known as TNF-related apoptosis-inducing ligand receptor 1 (TRAIL-R1), Death receptor 4 (DR4), CD261 and APO2, which belongs to TNF superfamily. TNFRSF10A DR4 is widely expressed and high levels are found in spleen, peripheral blood leukocytes, small intestine and thymus, but also in K-562 erythroleukemia cells, MCF-7 breast carcinoma cells and activated T-cells. APO2 TNFRSF10A is receptor for the cytotoxic ligand TNFSF10 TRAIL. This receptor is activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF1 TRAIL), and thus transduces cell death signal and induces cell apoptosis. TRAIL R1 can promote the activation of NF-kappa-B. TRAIL R1 CD261 TNFRSF1A induces apoptosis of many transformed cell lines but not of normal tissues, even though its death domain-containing receptor, DR4, is expressed on both cell types.
    • ¥ 380
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  • TNF RII Protein, Rhesus macaque, Recombinant (His)
    TMPJ-00619
    TNF RII Protein, Rhesus macaque, Recombinant (His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 35-45 KDa and the accession number is F7EAF8.
    • ¥ 760
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  • LTBR Protein, Mouse, Recombinant (hFc)
    TMPJ-00994
    It is a single-pass type I membrane protein and contains 4 TNFR-Cys repeats. The protein is a member of the tumor necrosis factor (TNF) family of receptors. It is expressed on the surface of most cell types, including cells of epithelial and myeloid lineages, but not on T and B lymphocytes. The protein is the receptor for the heterotrimeric lymphotoxin containing LTA and LTB, and for TNFS14 LIGHT. It promotes apoptosis via TRAF3 and TRAF5 and may play a role in the development of lymphoid organs. The encoded protein and its ligand play a role in the development and organization of lymphoid tissue and transformed cells. Activation of the encoded protein can trigger apoptosis. Not only does the TNFRSF3 help trigger apoptosis, it can lead to the release of the cytokine interleukin 8. Overexpression of TNFRSF3 in Human Cells cells increases IL-8 promoter activity and leads to IL-8 release. TNFRSF3 is also essential for development and organization of the secondary lymphoid organs and chemokine release.
    • ¥ 740
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  • BCMA/TNFRSF17 Protein, Cynomolgus, Recombinant (His)
    TMPJ-01446
    BCMA TNFRSF17 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 12 and 15-20 KDa and the accession number is G7Q0I4.
    • ¥ 550
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  • GITR/TNFRSF18 Protein, Human, Recombinant (aa 26-161, His)
    TMPK-00133
    GITR (glucocorticoid-induced tumor necrosis factor receptor), also known as AITR and TNFRSF18, is a 40 kDa transmembrane glycoprotein that functions in immune regulation.GIRT is a receptor for TNFSF18. Seems to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. Mediated NF-kappa-B activation via the TRAF2 NIK pathway. GITR TNFRSF18 Protein, Human, Recombinant (aa 26-161, His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 15.4 kDa and the accession number is Q9Y5U5-1.
    • ¥ 2660
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  • TRAIL R4/TNFRSF10D Protein, Human, Recombinant (His & Avi)
    TMPK-00248
    TNF-related apoptosis inducing ligand (TRAIL) is a potential antitumor protein known for its ability to selectively eliminate various types of tumor cells without exerting toxic effects in normal cells and tissues. TRAIL-R2 DR5 as well as TRAIL-R3 DcR1 and TRAIL-R4 DcR2 were significantly higher expressed in advanced tumour stages. TRAIL R4 TNFRSF10D Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 19.4 kDa and the accession number is Q9UBN6.
    • ¥ 3100
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  • DR3/TNFRSF25 Protein, Mouse, Recombinant (His)
    TMPK-00631
    TNF-like ligand 1 A (TL1A) and death receptor 3 (DR3) are a ligand-receptor pair involved in the pathogenesis of inflammatory bowel disease. Group 3 innate lymphoid cells (ILC3s) regulate intestinal immunity and highly express DR3.
    • ¥ 3100
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  • RANK/TNFRSF11A Protein, Mouse, Recombinant (hFc)
    TMPK-00723
    TNFRSF11A, also known as receptor activator of NF-κB (RANK), activates several signaling pathways, such as NF-κB, JNK, ERK, p38α, and Akt PKB. RANK TNFRSF11A is a novel and frequent target for de novo methylation in gliomas, which affects apoptotic activity and focus formation thereby contributing to the molecular pathogenesis of gliomas. RANK TNFRSF11A Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-hFc tag. The predicted molecular weight is 47.0 kDa and the accession number is O35305.
    • ¥ 3100
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  • TNFR2/CD120b/TNFR1B Protein, Cynomolgus, Recombinant (His)
    TMPK-01382
    Tumor Necrosis Factor Receptor II (TNF RII), also known as TNFRSF1B, p75 p80, and CD120b, is a type I transmembrane protein that belongs to the TNF receptor superfamily. It has a molecular weight of approximately 75 kDa.Receptor with high affinity for TNFSF2 TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1 lymphotoxin-alpha. The TRAF1 TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B TNFR2. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity.
    • ¥ 2360
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  • GITR/TNFRSF18 Protein, Mouse, Recombinant (aa 22-153, His)
    TMPK-01086
    GITR (glucocorticoid-induced tumor necrosis factor receptor), also known as AITR and TNFRSF18, is a 40 kDa transmembrane glycoprotein that functions in immune regulation.GIRT is a receptor for TNFSF18. Seems to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. Mediated NF-kappa-B activation via the TRAF2 NIK pathway. GITR TNFRSF18 Protein, Mouse, Recombinant (aa 22-153, His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 15.2 kDa and the accession number is Q8C4K3.
    • ¥ 2660
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  • BAFFR/TNFRSF13C Protein, Cynomolgus, Recombinant (His)
    TMPK-01254
    BAFF binds to three TNF receptor superfamily members: B-cell maturation antigen (BCMA TNFRSF17), transmembrane activator and calcium-modulator and cyclophilin ligand interactor (TACI TNFRSF13B) and BAFF receptor (BAFF R BR3 TNFRSF13C). These receptors are type III transmembrane proteins that lack a signal peptide. Whereas TACI and BCMA bind BAFF and another TNF superfamily ligand, APRIL (a proliferation-inducing ligand), BAFF R selectively binds BAFF.
    • ¥ 3100
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  • BCMA/TNFRSF17 Protein, Mouse, Recombinant (His & Avi)
    TMPK-00071
    B-cell maturation antigen (BCMA or BCM), also known as tumor necrosis factor receptor superfamily member 17 (TNFRSF17), is a protein that in humans is encoded by the TNFRSF17 gene.TNFRSF17 is a cell surface receptor of the TNF receptor superfamily which recognizes B-cell activating factor (BAFF). BCMA TNFRSF17 Protein, Mouse, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 8.5 kDa and the accession number is O88472-1.
    • ¥ 3400
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  • OX40/TNFRSF4 Protein, Human, Recombinant (aa 29-216, His & Avi), Biotinylated
    TMPK-00168
    Tumor necrosis factor receptor superfamily, member 4 (TNFRSF4), also known as CD134 and OX40 receptor. OX40 is a secondary co-stimulatory immune checkpoint molecule, expressed after 24 to 72 hours following activation; its ligand, OX40L, is also not expressed on resting antigen presenting cells, but is following their activation. OX40 TNFRSF4 Protein, Human, Recombinant (aa 29-216, His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 23.2 kDa and the accession number is P43489.
    • ¥ 5180
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  • OX40/TNFRSF4 Protein, Mouse, Recombinant (His & Avi)
    TMPK-00463
    Tumor necrosis factor receptor superfamily, member 4 (TNFRSF4), also known as CD134 and OX40 receptor. OX40 is a secondary co-stimulatory immune checkpoint molecule, expressed after 24 to 72 hours following activation; its ligand, OX40L, is also not expressed on resting antigen presenting cells, but is following their activation. OX40 TNFRSF4 Protein, Mouse, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 24.2 kDa and the accession number is P47741.
    • ¥ 2060
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  • BCMA/TNFRSF17 Protein, Mouse, Recombinant (His & hFc)
    TMPY-01211
    BCMA TNFRSF17 Protein, Mouse, Recombinant (His & hFc) is expressed in HEK293 mammalian cells with His and hFc tag. The predicted molecular weight is 33.7 kDa and the accession number is O88472-1.
    • ¥ 3820
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  • DR5/TRAIL R2 Protein, Mouse, Recombinant (His)
    TMPY-01437
    DR5 TRAIL R2 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 15 kDa and the accession number is Q9QZM4.
    • ¥ 3170
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  • Fas/CD95 Protein, Mouse, Recombinant (His)
    TMPY-01426
    Fas CD95 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 18 kDa and the accession number is P25446.
    • ¥ 3820
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  • CD27/TNFRSF7 Protein, Mouse, Recombinant (His & hFc)
    TMPY-01378
    CD27 TNFRSF7 Protein, Mouse, Recombinant (His & hFc) is expressed in HEK293 mammalian cells with His and hFc tag. The predicted molecular weight is 46.2 kDa and the accession number is P41272.
    • ¥ 4460
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  • GITR/TNFRSF18 Protein, Human, Recombinant (His)
    TMPY-00072
    GITR TNFRSF18 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 16 kDa and the accession number is Q9Y5U5-3.
    • ¥ 2930
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  • DR6 Protein, Cynomolgus, Recombinant (His)
    TMPY-00263
    DR6 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 35 kDa and the accession number is A0A2K5VIJ8.
    • ¥ 3820
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  • TNFR1/CD120a/TNFRSF1A Protein, Human, Recombinant (His)
    TMPY-01459
    TNFR1 CD120a TNFRSF1A Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 22.7 kDa and the accession number is P19438-1.
    • ¥ 2600
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  • DR5/TRAIL R2 Protein, Mouse, Recombinant (His & hFc)
    TMPY-01452
    DR5 TRAIL R2 Protein, Mouse, Recombinant (His & hFc) is expressed in HEK293 mammalian cells with His and hFc tag. The predicted molecular weight is 41.8 kDa and the accession number is Q9QZM4.
    • ¥ 3170
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  • CD27/TNFRSF7 Protein, Mouse, Recombinant (His)
    TMPY-01432
    CD27 TNFRSF7 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 19.6 kDa and the accession number is P41272.
    • ¥ 4460
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  • DR4/TRAIL R1 Protein, Human, Recombinant (His)
    TMPY-01720
    DR4 TRAIL R1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 15.7 kDa and the accession number is O00220.
    • ¥ 2530
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  • Fas/CD95 Protein, Rat, Recombinant (His)
    TMPY-02057
    Fas CD95 Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 18 kDa and the accession number is A6I127.
    • ¥ 3820
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  • 4-1BB/CD137/TNFRSF9 Protein, Human, Recombinant (His)
    TMPY-01743
    4-1BB CD137 TNFRSF9 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 18.8 kDa and the accession number is Q07011.
    • ¥ 2200
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  • Fas/CD95 Protein, Human, Recombinant (His)
    TMPY-01704
    Fas CD95 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 18.2 kDa and the accession number is P25445-1.
    • ¥ 3820
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  • EDA2R Protein, Human, Recombinant (His)
    TMPY-01932
    EDA2R Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 16.7 kDa and the accession number is Q9HAV5-1.
    • ¥ 3820
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  • BAFFR/TNFRSF13C Protein, Mouse, Recombinant (hFc)
    TMPY-02186
    BAFFR TNFRSF13C Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 33.7 kDa and the accession number is Q9D8D0-1.
    • ¥ 3820
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  • LTBR Protein, Rat, Recombinant (His)
    TMPY-02771
    LTBR Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 23 kDa and the accession number is Q5U2S8.
    • ¥ 4460
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  • CD40 Protein, Canine, Recombinant (His)
    TMPY-04089
    CD40 Protein, Canine, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 20.5 kDa and the accession number is Q7YRL5.
    • ¥ 3820
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  • RANK/TNFRSF11A Protein, Human, Recombinant (mFc)
    TMPY-05514
    RANK TNFRSF11A Protein, Human, Recombinant (mFc) is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 46.5 kDa and the accession number is Q9Y6Q6-3.
    • ¥ 3820
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  • DcR1/TRAILR3 Protein, Human, Recombinant (His)
    TMPY-04722
    TNFRSF10C CNV in patients with CRC is associated with distant metastatic disease. A high frequency of CGI methylation in the TNFRSF10C promoter results in inactivation of the gene and enhancement of tumor growth in most PC cell lines (except CFPAC-1). Inactivation of TNFRSF10C by CpG island (CGI) hypermethylation can play an important role in PC progression and be potentially useful as a diagnostic marker and a new therapeutic approach for PC.
    • ¥ 1960
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  • Osteoprotegerin Protein, Mouse, Recombinant (hFc)
    TMPY-04509
    Osteoprotegerin Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 70.2 kDa and the accession number is O08712.
    • ¥ 2530
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  • DR6 Protein, Rat, Recombinant (hFc)
    TMPY-04630
    DR6 Protein, Rat, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 60.5 kDa and the accession number is D3ZF92.
    • ¥ 2270
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  • BCMA/TNFRSF17 Protein, Human, Recombinant (mFc)
    TMPY-05197
    BCMA TNFRSF17 Protein, Human, Recombinant (mFc) is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 32.3 kDa and the accession number is Q02223-1.
    • ¥ 3820
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  • TNFR2/CD120b/TNFR1B Protein, Human, Recombinant (aa 1-268, M196A, His)
    TMPY-03881
    TNFR2 CD120b TNFR1B Protein, Human, Recombinant (aa 1-268, M196A, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 27.7 kDa and the accession number is P20333-2.
    • ¥ 3820
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  • BCMA/TNFRSF17 Protein, Human (His & hFc), PE conjugated
    TMPY-05568
    BCMA TNFRSF17 Protein, Human (His & hFc), PE conjugated is expressed in HEK293 mammalian cells with His and Fc tag. The accession number is NP_001183.2.
    • ¥ 2450
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  • HVEM Protein, Mouse, Recombinant (His)
    TMPY-05512
    HVEM Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 19.8 kDa and the accession number is Q80WM9.
    • ¥ 3820
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  • GITR/TNFRSF18 Protein, Mouse, Recombinant (His)
    TMPY-06017
    GITR TNFRSF18 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 15.5 kDa and the accession number is O35714-1.
    • ¥ 1450
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  • CD27/TNFRSF7 Protein, Human, Recombinant (His), Biotinylated
    TMPY-04951
    CD27 TNFRSF7 Protein, Human, Recombinant (His), Biotinylated is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 20.77 kDa and the accession number is P26842.
    • ¥ 1950
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