ExcisaninA may be a potent inhibitor of AKT signaling pathway in tumor cells, it can inhibit invasion by suppressing MMP-2 and MMP-9 expression, it may be a potential anti-metastatic chemotherapeutic agent for the treatment of breast cancer. Excisanin A shows comparable inhibitory effects on the LPS-induced production of NO and PGE2, and activation of NF-kappaB without affecting cell viability.Excisanin A induces apoptosis in colon cancer cell line SW620 as determined by Annexin V staining, the cleavage of caspase-3 and the proteolytic degradation of poly (ADP-ribose) polymerase (PARP).
Pedalitin is a mixed-type inhibitor of tyrosinase. In the assay of α-glucosidase inhibition, rosmarinic acid is a competitive inhibitor, whereas both methyl rosmarinate and Pedalitin are mixed-type inhibitors.
Effusanin E shows antibacterial and anti-cancer activities, it significantly inhibits cell proliferation and induces apoptosis in NPC cells by suppressing p50 p65 proteins to down-regulate COX-2 expression .
Hispidanin B shows significant cytotoxicities against tumor cell lines SGC7901, SMMC7721, and K562, with IC50 values of 10.7, 9.8, and 13.7 uM, respectively.
Epinodosin induces significant DNA damage to HepG2 cells in a time- and dose-dependent manner.Epinodosin has a biphasic, dose-dependent effect on root growth and a strong inhibitory effect on root hair development in Lactuca sativa L. seedlings.
Rabdosin B shows cytotoxic activity against three human tumour HepG2, GLC-82 and HL-60 cell lines, it induces significant DNA damage to HepG2 cells in a time- and dose-dependent manner. Rabdosin B at higher concentrations inhibits root growth by affecting