BCL6

BCL6 (B-cell lymphoma 6) is a zinc finger transcription factor that acts as a key regulator of B cell development and immune responses. It functions primarily as a transcriptional repressor, controlling genes involved in cell proliferation, apoptosis, and differentiation. BCL6 is essential for the formation of germinal centers during humoral immunity, where it regulates B cell maturation and antibody production. Dysregulation of BCL6 is associated with lymphomas, particularly diffuse large B-cell lymphoma (DLBCL), where it promotes cell survival and proliferation. Due to its critical role in immunity and cancer, BCL6 is a potential therapeutic target in hematological malignancies.